Gene Symbol: CFB
Description: complement factor B
Alias: AHUS4, ARMD14, BFD, CFAB, CFBD, FBI12, GBG, H2-Bf, PBF2, complement factor B, B-factor, properdin, C3 proaccelerator, C3 proactivator, C3/C5 convertase, glycine-rich beta-glycoprotein, properdin factor B
Species: human
Products:     CFB

Top Publications

  1. Maller J, Fagerness J, Reynolds R, Neale B, Daly M, Seddon J. Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat Genet. 2007;39:1200-1 pubmed
    ..We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample. ..
  2. Tawadrous H, Maga T, Sharma J, Kupferman J, Smith R, Schoeneman M. A novel mutation in the complement factor B gene (CFB) and atypical hemolytic uremic syndrome. Pediatr Nephrol. 2010;25:947-51 pubmed publisher
    We report the case of an 8-year-old girl diagnosed with atypical hemolytic uremic syndrome (aHUS) with a complement factor B (CFB) gene mutation. aHUS is a disease of complement dysregulation...
  3. Gold B, Merriam J, Zernant J, Hancox L, Taiber A, Gehrs K, et al. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet. 2006;38:458-62 pubmed
    ..These data expand and refine our understanding of the genetic risk for AMD. ..
  4. Montes T, Tortajada A, Morgan B, Rodriguez de Cordoba S, Harris C. Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B. Proc Natl Acad Sci U S A. 2009;106:4366-71 pubmed publisher
    ..Knowledge of the functional consequences of polymorphisms in complement activators and regulators will aid disease prediction and inform targeting of diagnostics and therapeutics. ..
  5. Kaur I, Katta S, Reddy R, Narayanan R, Mathai A, Majji A, et al. The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2010;51:59-63 pubmed publisher
    Genes involved in the complement cascade such as complement factor B (CFB) and complement component C2 have been implicated in age-related macular degeneration (AMD) worldwide...
  6. Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, et al. Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population. Invest Ophthalmol Vis Sci. 2012;53:794-8 pubmed publisher
    To determine whether genetic variants in the complement component 2 and factor B gene (C2/CFB) locus are associated with the risk for typical age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV) in a Japanese ..
  7. Buentello Volante B, Rodriguez Ruiz G, Miranda Duarte A, Pompa Mera E, Graue Wiechers F, Bekker Mendez C, et al. Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican population. Mol Vis. 2012;18:2518-25 pubmed
    ..association of age-related macular degeneration (AMD)-high risk alleles of the complement factor H (CFH), complement factor B (CFB), complement component 2 (C2), complement component 3 (C3), and age-related maculopathy susceptibility ..
  8. Lima L, Schubert C, Ferrara D, Merriam J, Imamura Y, Freund K, et al. Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy. Ophthalmology. 2010;117:1567-70 pubmed publisher
    ..To investigate the frequency of variants in 3 major age-related macular degeneration (AMD)-associated loci in patients of European-American descent with polypoidal choroidal vasculopathy (PCV)...
  9. Spencer K, Hauser M, Olson L, Schmidt S, Scott W, Gallins P, et al. Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration. Hum Mol Genet. 2007;16:1986-92 pubmed
    ..Recently, polymorphisms in the factor B (CFB) and complement component 2 (CC2) genes were associated with decreased susceptibility to AMD...

More Information

Publications114 found, 100 shown here

  1. Lee K, Vithana E, Mathur R, Yong V, Yeo I, Thalamuthu A, et al. Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci. 2008;49:2613-9 pubmed publisher
    ..Variants in the C2 and BF genes have been found to confer a significantly reduced risk of AMD. This study was undertaken to determine whether these associations occur in Chinese patients with PCV...
  2. McKay G, Silvestri G, Patterson C, Hogg R, Chakravarthy U, Hughes A. Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009;50:533-9 pubmed publisher
    ..Previous studies have identified polymorphisms in the complement component 2 (CC2) and factor B (CFB) genes, as potential functional variants associated with AMD, in particular CFB R32Q and CC2 rs547154, both of ..
  3. Chu J, Zhou C, Lu N, Zhang X, Dong F. Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population. Chin Med J (Engl). 2008;121:2525-33 pubmed replicate the associations of representative polymorphisms in three genes (complement factor H (CFH), complement factor B (BF) and HtrA serine peptidase 1 (HTRA1)) with exudative age-related macular degeneration (AMD) in a Han ..
  4. Chen W, Stambolian D, Edwards A, Branham K, Othman M, Jakobsdottir J, et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010;107:7401-6 pubmed publisher
    ..Our results validate AMD susceptibility loci near CFH (P < 10(-75)), ARMS2 (P < 10(-59)), C2/CFB (P < 10(-20)), C3 (P < 10(-9)), and CFI (P < 10(-6))...
  5. Neale B, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, et al. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A. 2010;107:7395-400 pubmed publisher
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD. ..
  6. Loyet K, DeForge L, Katschke K, Diehl L, Graham R, Pao L, et al. Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2012;53:6628-37 pubmed
    ..Increased activation of the alternative complement pathway in vitreous was controlled by disease stage and genetic variation in the complement pathway, supporting a role for complement activation in AMD disease pathogenesis. ..
  7. Spencer K, Olson L, Anderson B, Schnetz Boutaud N, Scott W, Gallins P, et al. C3 R102G polymorphism increases risk of age-related macular degeneration. Hum Mol Genet. 2008;17:1821-4 pubmed publisher
    ..Association of variants in the complement factor H (CFH) and complement factor B (CFB) genes has targeted the search for additional loci to the alternative complement cascade, of which C3 ..
  8. Seddon J, Reynolds R, Maller J, Fagerness J, Daly M, Rosner B. Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Invest Ophthalmol Vis Sci. 2009;50:2044-53 pubmed publisher
    ..4 (95% CI, 8.6-75.1) for LOC387715 A69S (ARMS2); 0.3 (95% CI, 0.1-0.7) for C2 E318D; 0.3 (95% CI, 0.1-0.5) for CFB; and 3.6 (95% CI, 1.4-9...
  9. Kondo N, Honda S, Kuno S, Negi A. Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology. Ophthalmology. 2009;116:1502-9 pubmed publisher 4 tightly linked genes of the major histocompatibility complex class III--complement component 2 (C2), complement factor B (CFB), RD RNA-binding protein (RDBP), and superkiller viralicidic activity 2-like (SKIV2L)--are associated ..
  10. Liu X, Zhao P, Tang S, Lu F, Hu J, Lei C, et al. Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese population. Retina. 2010;30:1177-84 pubmed publisher
    ..Seven SNPs in CFH and two SNPs in C2, CFB', and C3 were genotyped using the ABI SNaPshot method...
  11. Cipriani V, Leung H, Plagnol V, Bunce C, Khan J, Shahid H, et al. Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3. Hum Mol Genet. 2012;21:4138-50 pubmed publisher
    ..7 × 10(-72)), CFH (complement factor H) (P =2.3 × 10(-47)), C2 (complement component 2)-CFB (complement factor B) (P =5.2 × 10(-9)), C3 (complement component 3) (P =2.2 × 10(-3)) and CFI (P =3...
  12. Vieira Martins P, El Sissy C, Bordereau P, Gruber A, Rosain J, Fremeaux Bacchi V. Defining the genetics of thrombotic microangiopathies. Transfus Apher Sci. 2016;54:212-9 pubmed publisher
    ..five complement genes coding for complement factor H (CFH) complement factor I (CFI), MCP (CD46), C3 and complement factor B (CFB) have been demonstrated to increase the risk of developing aHUS, but several more genes have been ..
  13. Yoshida Y, Matsumoto M. [Atypical HUS caused by complement-related abnormalities]. Rinsho Ketsueki. 2015;56:185-93 pubmed publisher
    ..factor I (CFI), membrane cofactor protein (MCP), thrombomodulin (THBD), complement component C3 (C3), and complement factor B (CFB)...
  14. Merle B, Silver R, Rosner B, Seddon J. Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study. Am J Clin Nutr. 2015;102:1196-206 pubmed publisher
    ..2/high-temperature requirement A serine peptidase 1 (ARMS2/HTRA1), complement component 2 (C2), complement factor B (CFB), complement component 3 (C3), collagen type VIII α 1 (COL8A1), and RAD51 paralog B (RAD51B)] were ..
  15. Proitsi P, Lupton M, Dudbridge F, Tsolaki M, Hamilton G, Daniilidou M, et al. Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. Neurobiol Aging. 2012;33:1843.e9-17 pubmed publisher
    ..H (CFH), the Age-related maculopathy susceptibility protein 2 (ARMS2) the complement component 2 (C2), the complement factor B (CFB), and the complement component 3 (C3) genes...
  16. Visconti L, Cernaro V, Ardissino G, Sgarbanti M, Ferrara D, Visconti G, et al. [Complement factor B mutation in atypical hemolytic uremic syndrome. Rare cause of rare disease]. G Ital Nefrol. 2017;34:74-81 pubmed
    ..Genetic screening has revealed a heterozygous mutation in the complement factor B (CFB) that is not described in the literature and therefore not yet characterized in the genotype/phenotype ..
  17. Cobourne Duval M, Taka E, Mendonça P, Soliman K. Thymoquinone increases the expression of neuroprotective proteins while decreasing the expression of pro-inflammatory cytokines and the gene expression NF?B pathway signaling targets in LPS/IFN? -activated BV-2 microglia cells. J Neuroimmunol. 2018;320:87-97 pubmed publisher >7 fold down-regulation of several NF?B signaling targets genes, including interleukin 6 (IL6), complement factor B (CFB), chemokine (CC motif) ligand 3 (CXCL3), chemokine (CC) motif ligand 5 (CCL5) compared to the ..
  18. Zhu Z, Chen H, Gill R, Wang J, Spitalewitz S, Gotlieb V. Diabetic ketoacidosis presenting with atypical hemolytic uremic syndrome associated with a variant of complement factor B in an adult: a case report. J Med Case Rep. 2016;10:38 pubmed publisher
    ..Complement sequencing subsequently revealed a potential causative mutation in exon 12 of complement factor B with changes of lysine at amino acid position 533 to an arginine (CFB p.K533R)...
  19. Cavalcante M, Torres Romero J, Lobo M, Moreno F, Bezerra L, Lima D, et al. A panel of glycoproteins as candidate biomarkers for early diagnosis and treatment evaluation of B-cell acute lymphoblastic leukemia. Biomark Res. 2016;4:1 pubmed publisher
    ..II (SERPIND1), alpha-2-macroglobulin (A2M), alpha-2-antiplasmin (SERPINF2), Alpha-1 antitrypsin (SERPINA1), Complement factor B (CFB) and Complement C3 (C3) were identified as candidate biomarkers for early diagnosis of B-ALL, as they ..
  20. Estelius J, Lengqvist J, Ossipova E, Idborg H, Le Maitre E, Andersson M, et al. Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients-immune-related candidate proteins affected by TNF blocking treatment. Arthritis Res Ther. 2019;21:60 pubmed publisher
    ..gamma chain (FGG), hemopexin (HPX), cell adhesion molecule-3 (CADM3), alpha-1B-glycoprotein (A1BG), complement factor B (CFB), and beta-2-microglobulin (B2M), were selected for further studies based on identification by both ..
  21. Suman S, Basak T, Gupta P, Mishra S, Kumar V, Sengupta S, et al. Quantitative proteomics revealed novel proteins associated with molecular subtypes of breast cancer. J Proteomics. 2016;148:183-93 pubmed publisher
    ..Alpha-2-macroglobulin (A2M), and Complement component-4-binding protein-alpha (C4BPA) and Complement factor-B (CFB) were selected for validation in BC subtypes and healthy subjects in the independent set of blood plasma (N=100) ..
  22. Wu J, Huang D, Su X, Yan H, Sun Z. Oral administration of low-dose bisphenol A promotes proliferation of ventral prostate and upregulates prostaglandin D2 synthase expression in adult rats. Toxicol Ind Health. 2015;: pubmed
    ..showed that BPA induced upregulation of prostaglandin D2 synthase (Ptgds), Fas, Pbef1, and complement factor B (Cfb)as well as downregulation of Pttg1 and Fabp4 in the VP...
  23. Butler J, Hall N, Narendran N, Yang Y, Paraoan L. Identification of candidate protective variants for common diseases and evaluation of their protective potential. BMC Genomics. 2017;18:575 pubmed publisher
    ..One is in the complement component 2 gene (C2; E318D) and the other is in the complement factor B gene (CFB; R32Q)...
  24. Merchant M, Brier M, Slaughter M, Klein J, McLeish K. Biomarker enhanced risk prediction for development of AKI after cardiac surgery. BMC Nephrol. 2018;19:102 pubmed publisher
    ..Confirmatory ELISA measurements of five candidate markers showed urinary complement factor B (CFB) and histidine rich glycoprotein (HRG) concentrations were significantly increased in patients with ..
  25. Thelin E, Just D, Frostell A, Häggmark Månberg A, Risling M, Svensson M, et al. Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers. Behav Brain Res. 2018;340:71-80 pubmed publisher
    ..We found that complement factor 9 (C9), complement factor B (CFB) and aldolase c (ALDOC) were detected at higher levels the first days after trauma...
  26. Michalovicz L, Lally B, Konat G. Peripheral challenge with a viral mimic upregulates expression of the complement genes in the hippocampus. J Neuroimmunol. 2015;285:137-42 pubmed publisher
    ..The gene encoding complement factor B (CfB) exhibited the highest response, and its upregulation was commensurate with the development of ..
  27. McElroy J, Cree B, Caillier S, Gregersen P, Herbert J, Khan O, et al. Refining the association of MHC with multiple sclerosis in African Americans. Hum Mol Genet. 2010;19:3080-8 pubmed publisher
  28. Schwaeble W, Luttig B, Sokolowski T, Estaller C, Weiss E, Meyer zum Buschenfelde K, et al. Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase. Immunobiology. 1993;188:221-32 pubmed
    The human complement factor B is a centrally important component of the alternative pathway activation of the complement system...
  29. Tang M, Gao N, Zhou J, Zhao Y, Cheng J, Su W, et al. Improvement of sulfamethoxazole (SMX) elimination and inhibition of formations of hydroxylamine-SMX and N4-acetyl-SMX by membrane bioreactor systems. Biodegradation. 2018;29:245-258 pubmed publisher
    ..membrane bioreactor system (MBRS) was applied to improve SMX elimination thorough exchanging the cell-free broths (CFB). The removal efficiency of SMX was increased by more than 24% whether under the pure culture of A...
  30. Wu L, Tao Q, Chen W, Wang Z, Song Y, Sheng S, et al. Association between polymorphisms of complement pathway genes and age-related macular degeneration in a Chinese population. Invest Ophthalmol Vis Sci. 2013;54:170-4 pubmed publisher
    ..genes, including rs800292 and rs1410996 of complement H (CFH), rs9332739 of complement 2 (C2), rs4151667 of complement factor B (CFB), and rs2241394 and rs2230199 of complement 3 (C3)...
  31. Samoni S, Vigo V, Reséndiz L, Villa G, De Rosa S, Nalesso F, et al. Impact of hyperhydration on the mortality risk in critically ill patients admitted in intensive care units: comparison between bioelectrical impedance vector analysis and cumulative fluid balance recording. Crit Care. 2016;20:95 pubmed publisher
    ..mortality risk, comparing Bioelectrical Impedance Vector Analysis (BIVA) assessment with cumulative fluid balance (CFB) recording...
  32. Kim S, Lee S, Kim N, Chin H. Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population. Exp Eye Res. 2012;96:42-7 pubmed publisher
    This study was to investigate the association of genetic polymorphisms in complement component 2 (C2), complement factor B (CFB) and complement component 3 (C3) with exudative age-related macular degeneration (AMD) in a Korean population ..
  33. Imamura H, Konomoto T, Tanaka E, Hisano S, Yoshida Y, Fujimura Y, et al. Familial C3 glomerulonephritis associated with mutations in the gene for complement factor B. Nephrol Dial Transplant. 2015;30:862-4 pubmed publisher
    We report the first case of familial C3 glomerulonephritis (C3GN) associated with mutations in the gene for complement factor B (CFB). A 12-year-old girl was diagnosed with biopsy-proven C3GN...
  34. Herrmann P, Cowing J, Cristante E, Liyanage S, Ribeiro J, Duran Y, et al. Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age. Neurobiol Aging. 2015;36:2637-48 pubmed publisher
    ..With age, they revealed increased expression of activators of the alternative complement pathway (C3, Cfb, Cfd), in particular in the retinal pigment epithelium (RPE)-choroid but less in the retina...
  35. Gillingham S, Yunusova Y, Ganda A, Rogaeva E, Black S, Stuss D, et al. Assessing cognitive functioning in ALS: A focus on frontal lobe processes. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18:182-192 pubmed publisher
    ..were modified into an assessment battery appropriate for individuals with ALS in a clinical setting (the ALS-CFB, Computerised Frontal Battery)...
  36. Song S, Zhao J, Li C. Species delimitation and phylogenetic reconstruction of the sinipercids (Perciformes: Sinipercidae) based on target enrichment of thousands of nuclear coding sequences. Mol Phylogenet Evol. 2017;111:44-55 pubmed publisher
    ..undulata. We found that both S. loona and C. liui are valid species using Bayes factor delimitation (BFD∗) based on SNPs data. Species delimitation also provided decisive support for S. chuatsi and S...
  37. Williams M, McKay G, Carson R, Craig D, Silvestri G, Passmore P. Age-Related Macular Degeneration-Associated Genes in Alzheimer Disease. Am J Geriatr Psychiatry. 2015;23:1290-1296 pubmed publisher
    ..Polymorphisms in the following genes were studied: CFH, ARMS2, C2/CFB, C3, CFI/PLA2G12a, SERPING1, TLR3, TLR4, CRP, APOE, and TOMM40. Haplotypes were analysed for CFH, TOMM40, and APOE...
  38. Ahn M, Hwang J, Kim M, Park K. Antilipidemic effects and gene expression profiling of the glycosaminoglycans from cricket in rats on a high fat diet. Arch Pharm Res. 2016;39:926-36 pubmed publisher
    ..Antiatherosclerotic and antilipidemic effects of the GAG of G. bimaculatus (GbG, 5 or 10 mg/kg) were investigated in 15-week old Wistar rats treated with GbG for over a month...
  39. Minchin J, Rawls J. Elucidating the role of plexin D1 in body fat distribution and susceptibility to metabolic disease using a zebrafish model system. Adipocyte. 2017;6:277-283 pubmed publisher
    ..The regional distribution of lipid deposited within adipose tissue (AT) - so called body fat distribution (BFD) - is a strong risk factor for NCDs...
  40. Yu Y, Bhangale T, Fagerness J, Ripke S, Thorleifsson G, Tan P, et al. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet. 2011;20:3699-709 pubmed publisher the two novel loci, 10 previously reported loci in ARMS2/HTRA1 (rs10490924), CFH (rs1061170, and rs1410996), CFB (rs641153), C3 (rs2230199), C2 (rs9332739), CFI (rs10033900), LIPC (rs10468017), TIMP3 (rs9621532) and CETP (..
  41. Ma L, Li Z, Liu K, Rong S, Brelén M, Young A, et al. Association of Genetic Variants with Polypoidal Choroidal Vasculopathy: A Systematic Review and Updated Meta-analysis. Ophthalmology. 2015;122:1854-65 pubmed publisher
    ..2 [ARMS2], high-temperature requirement factor A1 [HTRA1], complement factor H [CFH], complement component 2 [C2], CFB, RDBP, SKIV2L, CETP, 8p21, and 4q12) were significantly associated with PCV...
  42. Brosig A, Kuhrt H, Wiedemann P, Kohen L, Bringmann A, Hollborn M. Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA. Mol Vis. 2015;21:1000-16 pubmed
    ..factor bFGF, inflammatory factors (IL-1β, IL-6, TNFα, MCP-1, MIP-2), and complement factors (C5, C9, CFB)...
  43. Berg J, Bradshaw C, Jo B, Ialongo N. Using Complier Average Causal Effect Estimation to Determine the Impacts of the Good Behavior Game Preventive Intervention on Teacher Implementers. Adm Policy Ment Health. 2017;44:558-571 pubmed publisher
    ..In the current study, CACE was used to examine one-year impacts of PAX good behavior game (PAX GBG) and promoting alternative thinking strategies (PATHS) on teacher efficacy and burnout...
  44. Spilt J, Leflot G, Onghena P, Colpin H. Use of Praise and Reprimands as Critical Ingredients of Teacher Behavior Management: Effects on Children's Development in the Context of a Teacher-Mediated Classroom Intervention. Prev Sci. 2016;17:732-42 pubmed publisher
    ..We also found indirect effects of the Good Behavior Game (GBG) on child outcomes via teacher praise and reprimands...
  45. Khorshidi A. Gold nanoparticles production using reactor and cyclotron based methods in assessment of (196,198)Au production yields by (197)Au neutron absorption for therapeutic purposes. Mater Sci Eng C Mater Biol Appl. 2016;68:449-454 pubmed publisher
    ..via simulated new neutron activator containing beryllium target, bismuth moderator around the target, and also PbF2 reflector enclosed the moderator region...
  46. Hecker L, Edwards A, Ryu E, Tosakulwong N, Baratz K, Brown W, et al. Genetic control of the alternative pathway of complement in humans and age-related macular degeneration. Hum Mol Genet. 2010;19:209-15 pubmed publisher
    ..Genetic variation across the genes encoding complement factor H (CFH), factor B (CFB) and component 3 (C3) was determined...
  47. Loane E, Nolan J, McKay G, Beatty S. The association between macular pigment optical density and CFH, ARMS2, C2/BF, and C3 genotype. Exp Eye Res. 2011;93:592-8 pubmed publisher
    ..These findings suggest that the maculae of subjects at very high genetic risk of AMD represent a hostile environment for accumulation and/or stabilization of MP. ..
  48. Matsunaga H, Iwashita M, Shinjo T, Yamashita A, Tsuruta M, Nagasaka S, et al. Adipose tissue complement factor B promotes adipocyte maturation. Biochem Biophys Res Commun. 2018;495:740-748 pubmed publisher
    ..Observational studies have indicated that complement system-related molecules such as complement factor B (CfB) and other components are correlated with obesity and/or insulin resistance parameters...
  49. Kavanagh D, Kemp E, Richards A, Burgess R, Mayland E, Goodship J, et al. Does complement factor B have a role in the pathogenesis of atypical HUS?. Mol Immunol. 2006;43:856-9 pubmed
    Atypical haemolytic uraemic syndrome (aHUS) is a disorder of complement dysregulation. Because complement factor B (fB) carries the catalytic site of the alternative pathway convertase we examined it as both a potential candidate gene ..
  50. Huang Y, Yu H, Chai C. Aldehyde dehydrogenase induction in arsenic-exposed rat bladder epithelium. Exp Toxicol Pathol. 2016;68:61-8 pubmed publisher
    ..relationship with arsenic exposure in the south-west coast of Taiwan (also known as the blackfoot disease (BFD) areas). However, the molecular mechanisms of arsenic-mediated UC carcinogenesis has not yet been defined...
  51. Picceli V, Skare T, Nisihara R, Nass F, Messias Reason I, Utiyama S. BF*F allotype of the alternative pathway of complement: A marker of protection against the development of antiphospholipid antibodies in patients with systemic lupus erythematosus. Lupus. 2016;25:412-7 pubmed publisher
    ..There is a link between phenotype BF SS07 and allotype BF*S07 with aCl-IgM in SLE patients; BF*F allotype could be considered a marker of protection against the development of antiphospholipid antibodies in these patients. ..
  52. Yang Z, Tang L, Zhou Z, Zhong G. Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF. Microbes Infect. 2016;18:669-674 pubmed publisher
    ..As a result, CPAF preferentially inhibited the alternative complement activation pathway. The significance and limitation of these observations were discussed. ..
  53. Kimura Y, Miwa T, Zhou L, Song W. Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement. Blood. 2008;111:732-40 pubmed
    ..These results reveal a novel role of properdin in AP complement initiation and have implications for understanding the selective predisposition of properdin-deficient patients to meningococcal infection. ..
  54. Blom A, Corvillo F, Magda M, Stasiłojć G, Nozal P, Pérez Valdivia M, et al. Testing the Activity of Complement Convertases in Serum/Plasma for Diagnosis of C4NeF-Mediated C3 Glomerulonephritis. J Clin Immunol. 2016;36:517-27 pubmed publisher
    ..Genetic analysis showed no mutations in C3, CFB, CFH, CFI, MCP, THBD, and DGKE genes...
  55. Kumar N, Kaur G, Tandon N, Mehra N. Allotyping human complement factor B in Asian Indian type 1 diabetic patients. Tissue Antigens. 2008;72:517-24 pubmed publisher
    Human complement factor B (BF) is an essential component of the alternate complement pathway and therefore important in innate immune and autoimmune responses...
  56. Keslar K, Rodriguez E, Tan C, Starling R, Heeger P. Complement gene expression in human cardiac allograft biopsies as a correlate of histologic grade of injury. Transplantation. 2008;86:1319-21 pubmed publisher
  57. Costa R, Abizaid A, Mehran R, Schofer J, Schuler G, Hauptmann K, et al. Polymer-Free Biolimus A9-Coated Stents in the Treatment of De Novo Coronary Lesions: 4- and 12-Month Angiographic Follow-Up and Final 5-Year Clinical Outcomes of the Prospective, Multicenter BioFreedom FIM Clinical Trial. JACC Cardiovasc Interv. 2016;9:51-64 pubmed publisher
    ..The BioFreedom (BFD) DCS incorporates a low-profile, stainless-steel platform, with a surface that has been modified to create a ..
  58. Ferreira A, Pasqualoto K, Kruyt F, Palace Berl F, Azevedo R, Turra K, et al. BFD-22 a new potential inhibitor of BRAF inhibits the metastasis of B16F10 melanoma cells and simultaneously increased the tumor immunogenicity. Toxicol Appl Pharmacol. 2016;295:56-67 pubmed publisher
    ..Cytotoxic effects of twenty-two BFDs were determined by MTT assay. Effects of BFD-22 in apoptosis and cell proliferation were evaluated using Annexin V-FITC/PI and CFSE staining...
  59. Gupta A, Juyal G, Sood A, Midha V, Yamazaki K, Vich Vila A, et al. A cross-ethnic survey of CFB and SLC44A4, Indian ulcerative colitis GWAS hits, underscores their potential role in disease susceptibility. Eur J Hum Genet. 2016;25:111-122 pubmed publisher
    ..GWAS) of ulcerative colitis in genetically distinct north Indian population identified two novel genes namely CFB and SLC44A4...
  60. Dong H, Dong S, Zhang L, Gao X, Lv G, Chen W, et al. MicroRNA-214 exerts a Cardio-protective effect by inhibition of fibrosis. Anat Rec (Hoboken). 2016;299:1348-57 pubmed publisher
    ..inhibitors of metalloproteinase (TIMP)-1 were all increased, but matrix metalloproteinase (MMP)-1 was reduced in CFB by Ang II treatment at both mRNA and protein levels, and these alterations were found reversed by miR-214 ..
  61. Riihilä P, Nissinen L, Farshchian M, Kallajoki M, Kivisaari A, Meri S, et al. Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma. Am J Pathol. 2017;187:1186-1197 pubmed publisher
    ..We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC...
  62. Babu M, Durga Devi T, Mäkinen P, Kaikkonen M, Lesch H, Junttila S, et al. Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice: Genome-Wide Promoter Methylation Study. Circ Res. 2015;117:289-99 pubmed publisher
    ..Classically activated M1-MÏ• gene promoters, including Cfb, Serping1, and Tnfsf15, were significantly hypomethylated, whereas alternatively activated M2-MÏ• gene promoters,..
  63. Zhou X, Wang H, Cui J, Qiu X, Chang Y, Wang X. Transcriptome analysis of tube foot and large scale marker discovery in sea cucumber, Apostichopus japonicus. Comp Biochem Physiol Part D Genomics Proteomics. 2016;20:41-49 pubmed publisher
    ..foot were also predicted based on the transcriptome, which contain immune-related factors (MBL, VLRA, AjC3, MyD88, CFB), skin pigmentation (MITF), candidate regeneration factor (TRP) and holothurians autolysis-related factor (CL)...
  64. Baatz H, Poupel L, Coudert M, Sennlaub F, Combadiere C. [Polymorphisms of complement factor genes and age-related macular degeneration in a German population]. Klin Monbl Augenheilkd. 2009;226:654-8 pubmed publisher
    ..rs2230199 (R102G) in the C 3 gene, rs547154 (IVS10) and rs9332739 (E318D) in the C 2 gene and rs4151667 (L9 H) in CFB gene, no associations with exsudative AMD were found...
  65. Valdes A, Thomson G. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Diabetes Obes Metab. 2009;11 Suppl 1:46-52 pubmed publisher
    ..Our data confirm that the class III region is involved in T1D susceptibility and suggest that more than one gene in the region is involved. ..
  66. Janssen B, Gomes L, Koning R, Svergun D, Koster A, Fritzinger D, et al. Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex. EMBO J. 2009;28:2469-78 pubmed publisher
    ..These insights into formation of convertases provide a basis for further development of complement therapeutics. ..
  67. Rodriguez de Cordoba S, Harris C, Morgan B, Llorca O. Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway. Biochim Biophys Acta. 2011;1812:12-22 pubmed publisher
    ..In addition, these functional data together with recent 3D structures of the AP C3 convertase have provided fundamental insights into the assembly, activation and regulation of the AP C3 convertase. ..
  68. Gilbert R, Fowler D, Angus E, Hardy S, Stanley L, Goodship T. Eculizumab therapy for atypical haemolytic uraemic syndrome due to a gain-of-function mutation of complement factor B. Pediatr Nephrol. 2013;28:1315-8 pubmed publisher
    ..treatment of this condition We present the first description of an infant with an activating mutation of complement factor B successfully treated with eculizumab...
  69. Petras H. Longitudinal Assessment Design and Statistical Power for Detecting an Intervention Impact. Prev Sci. 2016;17:819-29 pubmed publisher
    ..Estimates were extracted from a published evaluation of the proximal of the Good Behavior Game (GBG) on the developmental course of aggressive behavior...
  70. Brenner W, Leuendorf J, Cortleven A, Martin L, Schaller H, Schmülling T. Analysis of CFB, a cytokinin-responsive gene of Arabidopsis thaliana encoding a novel F-box protein regulating sterol biosynthesis. J Exp Bot. 2017;68:2769-2785 pubmed publisher
    ..We describe the analysis of the gene Cytokinin-induced F-box encoding (CFB, AT3G44326), identified in a meta-analysis of cytokinin-related transcriptome studies as one of the most robust ..
  71. Zamor K, Hoel A, Helenowski I, Beck A, Schneider J, Ho K. Comparison of Direct and Less Invasive Techniques for the Treatment of Severe Aorto-Iliac Occlusive Disease. Ann Vasc Surg. 2018;46:226-233 pubmed publisher
    ..However, cross-femoral bypass (CFB) and hybrid femoral endarterectomy and patch angioplasty with iliac stenting (EPS) have gained popularity as less ..
  72. Eike M, Olsson M, Undlien D, Dahl Jørgensen K, Joner G, Rønningen K, et al. Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families. Genes Immun. 2009;10:141-50 pubmed publisher
    ..Our results illustrate the importance of a comprehensive adjustment for LD effects when performing association studies in this complex. ..
  73. Francis P, Hamon S, Ott J, Weleber R, Klein M. Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss. J Med Genet. 2009;46:300-7 pubmed publisher
    ..0001, odds ratio (OR) 0.35, 95% confidence interval (CI) 0.2 to 0.6), CFB (p = 0.0001, OR 0.35, 95% CI 0.2 to 0.6), C3 (p = 0.0001, OR 3.91, 95% CI 1.94 to 7.88), APOE (epsilon4, p = 0...
  74. Kloeckener Gruissem B, Barthelmes D, Labs S, Schindler C, Kurz Levin M, Michels S, et al. Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD. Invest Ophthalmol Vis Sci. 2011;52:4694-702 pubmed publisher
    ..Genotypes of polymorphisms in known AMD susceptibility loci (CFH, CFB, HTRA1, AMRS2, and VEGFA) as well as not yet reported AMD-associated genes (KDR, LRP5, and FZD4) were determined, ..
  75. Caire J, Recalde S, Velazquez Villoria A, García García L, REITER N, Anter J, et al. Growth of geographic atrophy on fundus autofluorescence and polymorphisms of CFH, CFB, C3, FHR1-3, and ARMS2 in age-related macular degeneration. JAMA Ophthalmol. 2014;132:528-34 pubmed
    ..Samples of DNA were collected to analyze SNPs within AMD-related genes (CFH, CFB, C3, FHR1-3, and ARMS2)...
  76. Juyal G, Negi S, Sood A, Gupta A, Prasad P, Senapati S, et al. Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis. Gut. 2015;64:571-9 pubmed publisher
    ..of such genes from the extended HLA region, we determined the percentage alternative pathway activity of complement factor B (CFB), the top novel hit. The activity was significantly different (p=0...
  77. Funato M, Uemura O, Ushijima K, Ohnishi H, Orii K, Kato Z, et al. A complement factor B mutation in a large kindred with atypical hemolytic uremic syndrome. J Clin Immunol. 2014;34:691-5 pubmed publisher
    Gain-of-function mutations in complement factor B (CFB) were recently identified in patients with atypical hemolytic uremic syndrome (aHUS), but are extremely rare...
  78. Thergaonkar R, Narang A, Gurjar B, Tiwari P, Puraswani M, Saini H, et al. Targeted exome sequencing in anti-factor H antibody negative HUS reveals multiple variations. Clin Exp Nephrol. 2018;22:653-660 pubmed publisher
    ..e., CFH, CFHR1-5, CFI, CFB, C3, CD46, MASP2, DGKE, ADAMTS13, THBD and PLG using next-generation DNA sequencing and for copy number variation ..
  79. Fearon D. Activation of the alternative complement pathway. CRC Crit Rev Immunol. 1979;1:1-32 pubmed
  80. Schreiber R, Pangburn M, Lesavre P, Muller Eberhard H. Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins. Proc Natl Acad Sci U S A. 1978;75:3948-52 pubmed
    ..Thus, initiation of the alternative pathway is a two-step process, the first being non-specific and the second being discriminatory. ..
  81. Bexborn F, Andersson P, Chen H, Nilsson B, Ekdahl K. The tick-over theory revisited: formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb). Mol Immunol. 2008;45:2370-9 pubmed
    ..Under conditions that totally inactivated C3bBb, C3(H(2)O)Bb still retained approximately 25% of its initial activity. ..
  82. McKay G, Dasari S, Patterson C, Chakravarthy U, Silvestri G. Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort. Mol Vis. 2010;16:194-9 pubmed
    ..Factor H (CFH), Age-Related Maculopathy Susceptibility 2 (ARMS2), Complement Component 2 (CC2), and Complement Factor B (CFB; OR=1.45; CI: 1.10-1.91; p=0.009)...
  83. Maga T, Nishimura C, Weaver A, Frees K, Smith R. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. Hum Mutat. 2010;31:E1445-60 pubmed publisher
    ..complement factor H (CFH), complement factor H-related 5 (CFHR5), complement factor I (CFI), CD46 (MCP), complement factor B (CFB), complement component 3 (C3) and thrombomodulin (THBD)...
  84. Hughes A, Mullan G, Bradley D. Complement factor B polymorphism 32W protects against age-related macular degeneration. Mol Vis. 2011;17:983-8 pubmed
    The 32Q (rs641153; A) and 32W (rs12614; T) variants of complement factor B (CFB) cause less efficient complement activation in vitro than the common 32R variant...
  85. Fan W, Cheng J, Zhang S, Liu X. Cloning and functions of the HBxAg-binding protein XBP1. Mol Med Rep. 2013;7:618-22 pubmed publisher
  86. Le Quintrec M, Zuber J, Moulin B, Kamar N, Jablonski M, Lionet A, et al. Complement genes strongly predict recurrence and graft outcome in adult renal transplant recipients with atypical hemolytic and uremic syndrome. Am J Transplant. 2013;13:663-75 pubmed publisher
    ..was identified in 39 (68%), in factor H (CFH), factor I (CFI), membrane cofactor-protein (MCP), C3 and factor B (CFB). At 5 years, death-censored graft survival was 51%. Disease recurrence was associated with graft loss (p = 0.001)...
  87. Wu C, Xu G, Tsai S, Freed W, Lee C. Transcriptional profiles of type 2 diabetes in human skeletal muscle reveal insulin resistance, metabolic defects, apoptosis, and molecular signatures of immune activation in response to infections. Biochem Biophys Res Commun. 2017;482:282-288 pubmed publisher
    ..PMAIP1), and notably include immune-related pathways suggestive of a response to various infectious diseases (C2, CFB, C4A, C4B, C1S, C1R, C3, HLA-DRA, HLA-DMA, HLA-DOA, and HLA-DPB1)...
  88. Zhu J, Demireva P, Kanner A, Pannullo S, Mehdorn M, Avgeropoulos N, et al. Health-related quality of life, cognitive screening, and functional status in a randomized phase III trial (EF-14) of tumor treating fields with temozolomide compared to temozolomide alone in newly diagnosed glioblastoma. J Neurooncol. 2017;135:545-552 pubmed publisher
    ..a secondary endpoint, was evaluated in per-protocol patient population and expressed as change from baseline (CFB) at 3, 6, and 9 months for each subscale in the EORTC QLQ-C30/BN20...
  89. Lambris J, Lao Z, Oglesby T, Atkinson J, Hack C, Becherer J. Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component. J Immunol. 1996;156:4821-32 pubmed
  90. Yu C. Molecular genetics of the human MHC complement gene cluster. Exp Clin Immunogenet. 1998;15:213-30 pubmed
    ..The complete genomic DNA sequence between C2 and TNX is now available. This should facilitate a complete documentation of polymorphisms, mutations and disease associations for the MCGC. ..
  91. Laich A, Sim R. Complement C4bC2 complex formation: an investigation by surface plasmon resonance. Biochim Biophys Acta. 2001;1544:96-112 pubmed
    ..Kd was 1.5x10(-8) M. Complement factor B (FB) was also tested for its binding to immobilised C4b...
  92. Rawal N, Pangburn M. Structure/function of C5 convertases of complement. Int Immunopharmacol. 2001;1:415-22 pubmed
    ..The process underlying the formation of high affinity C5 convertases during complement activation is discussed. ..