CETP

Summary

Gene Symbol: CETP
Description: cholesteryl ester transfer protein
Alias: BPIFF, HDLCQ10, cholesteryl ester transfer protein, BPI fold containing family F, cholesteryl ester transfer protein plasma, lipid transfer protein I
Species: human
Products:     CETP

Top Publications

  1. Borggreve S, Hillege H, Wolffenbuttel B, de Jong P, Zuurman M, van der Steege G, et al. An increased coronary risk is paradoxically associated with common cholesteryl ester transfer protein gene variations that relate to higher high-density lipoprotein cholesterol: a population-based study. J Clin Endocrinol Metab. 2006;91:3382-8 pubmed
    Several cholesteryl ester transfer protein (CETP) polymorphisms affect high-density lipoprotein (HDL) cholesterol, but the impact of CETP gene variants on incident coronary disease in the general population is uncertain after correction ..
  2. Calabresi L, Nilsson P, Pinotti E, Gomaraschi M, Favari E, Adorni M, et al. A novel homozygous mutation in CETP gene as a cause of CETP deficiency in a Caucasian kindred. Atherosclerosis. 2009;205:506-11 pubmed publisher
    To analyze the cholesteryl ester transfer protein (CETP) gene and the plasma HDL phenotype in a Caucasian subject with extremely elevated plasma high density lipoprotein-cholesterol (HDL-C)...
  3. Lie J, de Crom R, van Gent T, van Haperen R, Scheek L, Lankhuizen I, et al. Elevation of plasma phospholipid transfer protein in transgenic mice increases VLDL secretion. J Lipid Res. 2002;43:1875-80 pubmed
    Two lipid transfer proteins are active in human plasma, cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Mice by nature do not express CETP...
  4. Srivastava N, Achyut B, Prakash J, Agarwal C, Pant D, Mittal B. Association of cholesteryl ester transfer protein (TaqIB) and apolipoprotein E (HhaI) gene variants with obesity. Mol Cell Biochem. 2008;314:171-7 pubmed publisher
    ..We aimed to evaluate association of cholesteryl ester transfer protein (CETP) and apolipoprotein (APO) E gene variants with asymptomatic obesity...
  5. Qiu X, Mistry A, Ammirati M, Chrunyk B, Clark R, Cong Y, et al. Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat Struct Mol Biol. 2007;14:106-13 pubmed
    b>Cholesteryl ester transfer protein (CETP) shuttles various lipids between lipoproteins, resulting in the net transfer of cholesteryl esters from atheroprotective, high-density lipoproteins (HDL) to atherogenic, lower-density species...
  6. Saxena R, Voight B, Lyssenko V, Burtt N, de Bakker P, Chen H, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007;316:1331-6 pubmed
    ..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases. ..
  7. Kolovou G, Vasiliadis I, Kolovou V, Karakosta A, Mavrogeni S, Papadopoulou E, et al. The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease. Lipids Health Dis. 2011;10:156 pubmed publisher
    The cholesteryl ester transfer protein (CETP) has a central role in the lipid metabolism and therefore may alter the susceptibility to atherosclerosis...
  8. Klos K, Sing C, Boerwinkle E, Hamon S, Rea T, Clark A, et al. Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants. Arterioscler Thromb Vasc Biol. 2006;26:1828-36 pubmed
    ..To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels...
  9. Gauthier A, Lau P, Zha X, Milne R, McPherson R. Cholesteryl ester transfer protein directly mediates selective uptake of high density lipoprotein cholesteryl esters by the liver. Arterioscler Thromb Vasc Biol. 2005;25:2177-84 pubmed
    To determine whether cholesteryl ester transfer protein (CETP) directly mediates selective uptake of high-density lipoprotein (HDL)-cholesteryl ester (CE) by hepatocytes and to quantify the effects of the CETP inhibitor, torcetrapib, on ..

More Information

Publications143 found, 100 shown here

  1. Potter L, Sprecher D, Walker M, Tobin F. Mechanism of inhibition defines CETP activity: a mathematical model for CETP in vitro. J Lipid Res. 2009;50:2222-34 pubmed publisher
    Because cholesteryl ester transfer protein (CETP) inhibition is a potential HDL-raising therapy, interest has been raised in the mechanisms and consequences of CETP activity...
  2. de Vries R, Perton F, Dallinga Thie G, Van Roon A, Wolffenbuttel B, Van Tol A, et al. Plasma cholesteryl ester transfer is a determinant of intima-media thickness in type 2 diabetic and nondiabetic subjects: role of CETP and triglycerides. Diabetes. 2005;54:3554-9 pubmed
    ..thickness (IMT) is associated with plasma cholesteryl ester transfer (CET) and/or the plasma cholesteryl ester transfer protein (CETP) concentration in type 2 diabetic and control subjects...
  3. Poduri A, Khullar M, Bahl A, Sehrawat B, Sharma Y, Talwar K. Common variants of HMGCR, CETP, APOAI, ABCB1, CYP3A4, and CYP7A1 genes as predictors of lipid-lowering response to atorvastatin therapy. DNA Cell Biol. 2010;29:629-37 pubmed publisher
    ..We studied the association between 18 single-nucleotide polymorphisms (SNPs) in six genes (HMGCR, CETP, APOAI, ABCB1, CYP3A4, CYP7A1) in response to atorvastatin therapy (20 mg/day) in 265 newly diagnosed CAD ..
  4. Salerno A, Patrício P, Berti J, Oliveira H. Cholesteryl ester transfer protein (CETP) increases postprandial triglyceridaemia and delays triacylglycerol plasma clearance in transgenic mice. Biochem J. 2009;419:629-34 pubmed publisher
    The CETP (cholesteryl ester transfer protein) is a plasma protein synthesized in several tissues, mainly in the liver; CETP reduces plasma HDL (high-density lipoprotein) cholesterol and increases the risk of atherosclerosis...
  5. Cellini E, Nacmias B, Olivieri F, Ortenzi L, Tedde A, Bagnoli S, et al. Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians. Mech Ageing Dev. 2005;126:826-8 pubmed
    A common polymorphism (I405V) in exon 14 of the cholesteryl ester transfer protein (CETP) gene has been recently associated to healthy aging in Ashkenazi Jewish...
  6. Kashani Farid M, Azizi F, Hedayati M, Daneshpour M, Shamshiri A, Siassi F. Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study. Lipids Health Dis. 2010;9:96 pubmed publisher
    ..Polymorphisms in cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) genes have been found to be associated with the metabolism and ..
  7. Falchi A, Giovannoni L, Piras I, Calo C, Moral P, Vona G, et al. Prevalence of genetic risk factors for coronary artery disease in Corsica island (France). Exp Mol Pathol. 2005;79:210-3 pubmed
    ..system: Angiotensin converting enzyme (ACE I/D), (2) Lipid metabolism: Cholesterol Ester Transfer Protein gene (CETP TAQ1B), (3) Platelet aggregation: alpha and beta subunits of the platelet GpIIb/GpIIIa integrin complex (GpIIb HPA3 ..
  8. van Acker B, Botma G, Zwinderman A, Kuivenhoven J, Dallinga Thie G, Sijbrands E, et al. High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants. Atherosclerosis. 2008;200:161-7 pubmed publisher
    b>Cholesteryl ester transfer protein (CETP) and hepatic lipase (HL) are two HDL modifying proteins that have both pro- and anti-atherogenic properties...
  9. Klerkx A, Tanck M, Kastelein J, Molhuizen H, Jukema J, Zwinderman A, et al. Haplotype analysis of the CETP gene: not TaqIB, but the closely linked -629C-->A polymorphism and a novel promoter variant are independently associated with CETP concentration. Hum Mol Genet. 2003;12:111-23 pubmed
    The TaqIB polymorphism in intron 1 of the cholesteryl ester transfer protein (CETP) gene is associated with plasma CETP concentration, high-density lipoprotein cholesterol (HDL-C) and coronary artery disease (CAD)...
  10. Horne B, Camp N, Anderson J, Mower C, Clarke J, Kolek M, et al. Multiple less common genetic variants explain the association of the cholesteryl ester transfer protein gene with coronary artery disease. J Am Coll Cardiol. 2007;49:2053-60 pubmed
    The objective of this study was to identify associations of the cholesteryl ester transfer protein (CETP) gene with coronary artery disease (CAD) with tagging (t) single nucleotide polymorphisms (SNPs) chosen to optimally account for ..
  11. Anagnostopoulou K, Kolovou G, Kostakou P, Mihas C, Hatzigeorgiou G, Marvaki C, et al. Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia. Lipids Health Dis. 2009;8:24 pubmed publisher
    This study assessed the gender-specific influence of the cholesteryl ester transfer protein (TaqIB, I405V) and lipoprotein lipase (S447X) polymorphisms on the response to an oral fat tolerance test in heterozygotes for familial ..
  12. Mukherjee M, Shetty K. Variations in high-density lipoprotein cholesterol in relation to physical activity and Taq 1B polymorphism of the cholesteryl ester transfer protein gene. Clin Genet. 2004;65:412-8 pubmed
    ..of the study was to determine any association of physical activity and Taq 1B polymorphism in the cholesteryl ester transfer protein gene on high-density lipoprotein (HDL) cholesterol...
  13. Park K, Choi J, Kim H, Oh S, Chae I, Kim H, et al. The association of cholesteryl ester transfer protein polymorphism with high-density lipoprotein cholesterol and coronary artery disease in Koreans. Clin Genet. 2003;63:31-8 pubmed
    b>Cholesteryl ester transfer protein (CETP) is a key protein involved in high-density lipoprotein cholesterol (HDL-C) metabolism...
  14. Tanrikulu S, Ademoglu E, Gurdol F, Mutlu Turkoglu U, Bilge A, Nisanci Y. Association of cholesteryl ester transfer protein -629C > A polymorphism with high-density lipoprotein cholesterol levels in coronary artery disease patients. Cell Biochem Funct. 2009;27:452-7 pubmed publisher
    ..The cholesteryl ester transfer protein (CETP) -629C > A polymorphism is associated with lower plasma CETP concentration, with increased ..
  15. Tietjen I, Hovingh G, Singaraja R, Radomski C, Barhdadi A, McEwen J, et al. Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol. PLoS ONE. 2012;7:e37437 pubmed publisher
    ..Here we sequenced the coding regions and adjacent sequence of the LIPG, CETP, and GALNT2 genes in 171 unrelated Dutch Caucasian probands with HDLc?90th percentile and analyzed segregation of ..
  16. Arias Vasquez A, Isaacs A, Aulchenko Y, Hofman A, Oostra B, Breteler M, et al. The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease. Neurogenetics. 2007;8:189-93 pubmed
    ..apolipoprotein E (APOE) gene, the most common genetic determinant for Alzheimer's disease (AD), the cholesteryl ester transfer protein (CETP) is involved in lipid metabolism...
  17. Boekholdt S, Sacks F, Jukema J, Shepherd J, Freeman D, McMahon A, et al. Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects. Circulation. 2005;111:278-87 pubmed
    Several studies have reported that the cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism is associated with HDL cholesterol (HDL-C) levels and the risk of coronary artery disease (CAD), but the results are inconsistent...
  18. Curb J, Abbott R, Rodriguez B, Masaki K, Chen R, Sharp D, et al. A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly. J Lipid Res. 2004;45:948-53 pubmed
    ..Genetic factors, including variations in the cholesteryl ester transfer protein (CETP) gene, play a role in determining HDL-C levels...
  19. Relvas W, Izar M, Helfenstein T, Fonseca M, Colovati M, Oliveira A, et al. Relationship between gene polymorphisms and prevalence of myocardial infarction among diabetic and non-diabetic subjects. Atherosclerosis. 2005;178:101-5 pubmed
    This study was aimed to examine cholesteryl ester transfer protein (CETP), apolipoprotein AI and CIII gene polymorphisms, and to verify whether these genetic determinants are associated with the prevalence of myocardial infarction (MI) or ..
  20. Chamberlain A, Folsom A, Schreiner P, Boerwinkle E, Ballantyne C. Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis. 2008;200:322-8 pubmed publisher
    ..E (apoE Cys112Arg and Arg158Cys) gene and LDL-c levels, as well as the associations between the cholesteryl ester transfer protein (CETP TaqIB), hepatic lipase (LIPC C-514T), and lipoprotein lipase (LPL Ser447Stop) genes and HDL-c ..
  21. Charles M, Kane J. New molecular insights into CETP structure and function: a review. J Lipid Res. 2012;53:1451-8 pubmed publisher
    b>Cholesteryl ester transfer protein (CETP) is important clinically and is the current target for new drug development. Its structure and mechanism of action has not been well understood...
  22. Kathiresan S, Melander O, Anevski D, Guiducci C, Burtt N, Roos C, et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med. 2008;358:1240-9 pubmed publisher
    ..The score did not improve risk discrimination but did modestly improve clinical risk reclassification for individual subjects beyond standard clinical factors. ..
  23. Lu H, Inazu A, Moriyama Y, Higashikata T, Kawashiri M, Yu W, et al. Haplotype analyses of cholesteryl ester transfer protein gene promoter: a clue to an unsolved mystery of TaqIB polymorphism. J Mol Med (Berl). 2003;81:246-55 pubmed
    b>Cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters from HDL to triglyceride-rich lipoproteins...
  24. Zhang L, Yan F, Zhang S, Lei D, Charles M, Cavigiolio G, et al. Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein. Nat Chem Biol. 2012;8:342-9 pubmed publisher
    Human cholesteryl ester transfer protein (CETP) mediates the net transfer of cholesteryl ester mass from atheroprotective high-density lipoproteins to atherogenic low-density lipoproteins by an unknown mechanism...
  25. Kraja A, Vaidya D, Pankow J, Goodarzi M, Assimes T, Kullo I, et al. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes. 2011;60:1329-39 pubmed publisher
    ..RESULTS Twenty-nine common variants were associated with MetS or a pair of traits. Variants in the genes LPL, CETP, APOA5 (and its cluster), GCKR (and its cluster), LIPC, TRIB1, LOC100128354/MTNR1B, ABCB11, and LOC100129150 were ..
  26. Rahimi Z, Nourozi Rad R, Vaisi raygani A, Saidi M, Rahimi Z, Ahmadi R, et al. Association between cholesteryl ester transfer protein TaqIB variants and risk of coronary artery disease and diabetes mellitus in the population of western Iran. Genet Test Mol Biomarkers. 2011;15:813-9 pubmed publisher
    To shed light on the previously inconsistent results about the association of cholesteryl ester transfer protein TaqIB (CETP TaqIB) variants, high-density lipoprotein cholesterol (HDL-C) levels, and the risk of coronary artery disease (..
  27. Mohrschladt M, van der Sman de Beer F, Hofman M, van der Krabben M, Westendorp R, Smelt A. TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia. Eur J Hum Genet. 2005;13:877-82 pubmed
    The effects of TaqI restriction fragment length polymorphism of the CETP gene on the occurrence of cardiovascular disease (CVD) events were investigated in patients with familial hypercholesterolemia (FH)...
  28. Vergani C, Lucchi T, Caloni M, Ceconi I, Calabresi C, Scurati S, et al. I405V polymorphism of the cholesteryl ester transfer protein (CETP) gene in young and very old people. Arch Gerontol Geriatr. 2006;43:213-21 pubmed
    This study was designed to analyse the prevalence of I405V polymorphism in the cholesteryl ester transfer protein (CETP) gene, the CETP serum concentration, the lipoprotein profile, and certain clinical end-points in two populations, one ..
  29. Sandhofer A, Tatarczyk T, Laimer M, Ritsch A, Kaser S, Paulweber B, et al. The Taq1B-variant in the cholesteryl ester-transfer protein gene and the risk of metabolic syndrome. Obesity (Silver Spring). 2008;16:919-22 pubmed publisher
    ..The Taq1B-polymorphism in the cholesteryl ester-transfer protein (CETP)-gene influences HDL-C, CETP concentration, and LDL-size...
  30. Dixit M, Bhattacharya S, Mittal B. Association of CETP TaqI and APOE polymorphisms with type II diabetes mellitus in North Indians: a case control study. BMC Endocr Disord. 2005;5:7 pubmed
    ..Goal of the present study was to determine the association of cholesteryl ester transfer protein TaqI B, D442G, and APOE Hha I polymorphisms with T2DM and its complications...
  31. Dedoussis G, Panagiotakos D, Louizou E, Mantoglou I, Chrysohoou C, Lamnisou K, et al. Cholesteryl ester-transfer protein (CETP) polymorphism and the association of acute coronary syndromes by obesity status in Greek subjects: the CARDIO2000-GENE study. Hum Hered. 2007;63:155-61 pubmed
    Cholesterol ester transfer protein (CETP) regulates plasma lipid distribution. The present study aimed to investigate whether the CETP gene (Taq1B) polymorphism predisposes to Acute Coronary Syndromes (ACS) depending on obesity status...
  32. Liu J, Zhao D, Liu S, Liu J, Qin L, Wu Z. [Study on the distribution and association of cholesteryl ester transfer protein-TaqIB polymorphism and plasma concentration in general population]. Zhonghua Liu Xing Bing Xue Za Zhi. 2003;24:300-3 pubmed
    To study the distribution of cholesteryl ester transfer protein (CETP)-TaqIB polymorphism and plasma concentration in general population and the association between the two...
  33. Tsai M, Johnson C, Kao W, Sharrett A, Arends V, Kronmal R, et al. Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2008;200:359-67 pubmed publisher
    The cholesteryl ester transfer protein (CETP) plays a key role in high-density lipoprotein (HDL) metabolism...
  34. Cefalù A, Noto D, Magnolo L, Pinotti E, Gomaraschi M, Martini S, et al. Novel mutations of CETP gene in Italian subjects with hyperalphalipoproteinemia. Atherosclerosis. 2009;204:202-7 pubmed publisher
    b>Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that catalyses the transfer of cholesteryl esters from HDL to the other plasma lipoproteins...
  35. Al Daghri N, Al Attas O, Patel A, Belyaev N, Bartlett W, Jones A, et al. Association between the cholesteryl ester transfer protein TaqI-detectable B polymorphism and low high-density lipoprotein cholesterol concentration in Saudis. Clin Sci (Lond). 2003;105:467-72 pubmed
    ..A B polymorphism at the CETP (cholesteryl ester protein transfer) locus that is detectable with the restriction enzyme Taq I is a genetic ..
  36. Smart M, Dedoussis G, Louizou E, Yannakoulia M, Drenos F, Papoutsakis C, et al. APOE, CETP and LPL genes show strong association with lipid levels in Greek children. Nutr Metab Cardiovasc Dis. 2010;20:26-33 pubmed publisher
    ..of ten common variants in the genes for lipoprotein lipase (LPL-S447X), cholesterol ester transfer protein (CETP-Taq1B) apolipoprotein (APO) E (epsilon2, epsilon3, epsilon4), APOA5 (-1131C>T and S19W), APOA4 (S347T) and APOC3 ..
  37. Neale B, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, et al. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A. 2010;107:7395-400 pubmed publisher
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD. ..
  38. Dergunov A, Shabrova E, Dobretsov G. Cholesteryl ester diffusion, location and self-association constraints determine CETP activity with discoidal HDL: excimer probe study. Arch Biochem Biophys. 2014;564:211-8 pubmed publisher
    The transfer of cholesteryl ester by recombinant cholesteryl ester transfer protein (CETP) between reconstituted discoidal high-density lipoprotein (rHDL) was studied...
  39. Choi H, Park J, Han K, Yim C, Jung H, Jang H, et al. A common mutation in cholesteryl ester transfer protein gene and plasma HDL cholesterol level before and after hormone replacement therapy in Korean postmenopausal women. Korean J Intern Med. 2002;17:83-7 pubmed
    Plasma cholesteryl ester transfer protein (CETP) functions to transfer cholesteryl ester from HDL to triglyceride-rich lipoproteins and regulates plasma HDL cholesterol level...
  40. Freeman D, Samani N, Wilson V, McMahon A, Braund P, Cheng S, et al. A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study. Eur Heart J. 2003;24:1833-42 pubmed
    The association of cholesteryl ester transfer protein (CETP) gene polymorphisms with risk of a cardiovascular event and whether any association was explained by an influence on high-density lipoprotein (HDL) levels or low-density ..
  41. Thompson J, Durham L, Lira M, Shear C, Milos P. CETP polymorphisms associated with HDL cholesterol may differ from those associated with cardiovascular disease. Atherosclerosis. 2005;181:45-53 pubmed
    To better understand the role of cholesteryl ester transfer protein (CETP) in cardiovascular disease, nine polymorphisms spanning the gene from the upstream promoter region to beyond the 3'UTR were genotyped in 2553 individuals from ..
  42. Westerterp M, van der Hoogt C, de Haan W, Offerman E, Dallinga Thie G, Jukema J, et al. Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice. Arterioscler Thromb Vasc Biol. 2006;26:2552-9 pubmed
    The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate...
  43. Vasan R, Pencina M, Robins S, Zachariah J, Kaur G, D Agostino R, et al. Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community. Circulation. 2009;120:2414-20 pubmed publisher
    ..Inhibiting cholesteryl ester transfer protein (CETP) activity raises high-density lipoprotein cholesterol and may be cardioprotective, but an ..
  44. Lu Y, Tayebi N, Li H, Saha N, Yang H, Heng C. Association of CETP Taq1B and -629C?>?A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population. Lipids Health Dis. 2013;12:85 pubmed publisher
    Hyperlipidaemia is a major risk factor for coronary artery disease (CAD) and cholesteryl ester transfer protein (CETP) gene polymorphisms are known to be associated with lipid profiles...
  45. Zhao Y, Zhu W, Zhang Z, Li Y. [Relationship between gene polymorphism at CETP locus and hyperlipidemia in the middle-aged and the elder]. Wei Sheng Yan Jiu. 2004;33:94-7 pubmed
    The relationship between gene polymorphism at CETP locus and hyperlipidemia was examined in a 421 population-based sample (age from 35 to 81) from Xicheng district, Beijing...
  46. Spielmann N, Leon A, Rao D, Rice T, Skinner J, Bouchard C, et al. CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study. Physiol Genomics. 2007;31:25-31 pubmed
    Associations between cholesteryl ester transfer protein (CETP) polymorphisms and high-density lipoprotein cholesterol (HDL-c) levels before and after 20 wk of endurance training were investigated in the HERITAGE Family Study...
  47. Boekholdt S, Thompson J. Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease. J Lipid Res. 2003;44:1080-93 pubmed
    Since the identification of cholesteryl ester transfer protein (CETP), its role in the modulation of HDL levels and cardiovascular disease has been debated...
  48. Barzilai N, Atzmon G, Schechter C, Schaefer E, Cupples A, Lipton R, et al. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA. 2003;290:2030-40 pubmed
    ..Samples were also genotyped for the codon 405 isoleucine to valine (I405V) variation in the cholesteryl ester transfer protein (CETP) gene, which is involved in regulation of lipoprotein and its particle sizes...
  49. Fidani L, Goulas A, Crook R, Petersen R, Tangalos E, Kotsis A, et al. An association study of the cholesteryl ester transfer protein TaqI B polymorphism with late onset Alzheimer's disease. Neurosci Lett. 2004;357:152-4 pubmed
    b>Cholesteryl ester transfer protein (CETP) is reportedly able to affect the amount of cholesterol available for deposition and/or removal from peripheral tissues, in its capacity to mediate the transfer of cholesterol from high density ..
  50. Zheng K, Zhang S, Zhang L, He Y, Liao L, Hou Y, et al. Carriers of three polymorphisms of cholesteryl ester transfer protein gene are at increased risk to coronary heart disease in a Chinese population. Int J Cardiol. 2005;103:259-65 pubmed
    The cholesteryl ester transfer protein (CETP) is a key participant in the reverse transport of cholesterol from the peripheral tissue to the liver and the polymorphism in the CETP gene may therefore alter the susceptibility to coronary ..
  51. Elosua R, Cupples L, Fox C, Polak J, D Agostino R, Wolf P, et al. Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study. Atherosclerosis. 2006;189:222-8 pubmed
    ..In multivariable, sex-specific analyses, the rare allele of the cholesterol ester transfer protein (CETP) TaqIB variant was associated with lower ICA IMT in men...
  52. Koropatnick T, Kimbell J, Chen R, Grove J, Donlon T, Masaki K, et al. A prospective study of high-density lipoprotein cholesterol, cholesteryl ester transfer protein gene variants, and healthy aging in very old Japanese-american men. J Gerontol A Biol Sci Med Sci. 2008;63:1235-40 pubmed
    High-density lipoprotein cholesterol (HDL-C) and cholesteryl ester transfer protein (CETP) gene deficiency mutations that increase HDL-C levels have been associated with exceptional longevity...
  53. Weissglas Volkov D, Aguilar Salinas C, Sinsheimer J, Riba L, Huertas Vazquez A, Ordoñez Sánchez M, et al. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. Circ Cardiovasc Genet. 2010;3:31-8 pubmed publisher
    ..These variants were within or near the genes ABCA1, ANGPTL3, APOA5, APOB, CETP, GALNT2, GCKR, LCAT, LIPC, LPL (2), MMAB-MVK, TRIB1, and XKR6-AMAC1L2...
  54. de Grooth G, Zerba K, Huang S, Tsuchihashi Z, Kirchgessner T, Belder R, et al. The cholesteryl ester transfer protein (CETP) TaqIB polymorphism in the cholesterol and recurrent events study: no interaction with the response to pravastatin therapy and no effects on cardiovascular outcome: a prospective analysis of the CETP TaqIB. J Am Coll Cardiol. 2004;43:854-7 pubmed
    On the basis of quantitative coronary angiography data, the cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism has been postulated to predict the progression of coronary atherosclerosis and response to cholesterol-lowering ..
  55. Chaaba R, Hammami S, Attia N, Smaoui M, Masmoudi A, Mahjoub S, et al. Association of plasma cholesteryl ester transfer protein activity and polymorphism with coronary artery disease extent in Tunisian type II diabetic patients. Clin Biochem. 2005;38:373-8 pubmed
    b>Cholesteryl ester transfer protein (CETP), a key protein in reverse cholesterol transport, has a controversial role in atherosclerosis...
  56. Kolovou G, Anagnostopoulou K, Karyofillis P, Salpea K, Yiannakouris N, Zarkalis D, et al. Cholesteryl ester transfer protein gene polymorphisms and severity of coronary stenosis. Clin Invest Med. 2006;29:14-9 pubmed
    b>Cholesteryl ester transfer protein (CETP) gene is involved in the reverse cholesterol transport in humans. Thus, it is a candidate for studying the susceptibility to coronary heart disease (CHD)...
  57. Chen D, Yang J, Tang Z, Dong X, Feng X, Yu S, et al. Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon4 in Chinese. Brain Res. 2008;1187:52-7 pubmed
    ..It is known that the levels of HDL are regulated by cholesteryl ester transfer protein (CETP) and several single nucleotide polymorphisms (SNPs) in the CETP gene have been shown to be ..
  58. Chambers J, Elliott P, Zabaneh D, Zhang W, Li Y, Froguel P, et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet. 2008;40:716-8 pubmed publisher
    ..Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance. ..
  59. Hiura Y, Shen C, Kokubo Y, Okamura T, Morisaki T, Tomoike H, et al. Identification of genetic markers associated with high-density lipoprotein-cholesterol by genome-wide screening in a Japanese population: the Suita study. Circ J. 2009;73:1119-26 pubmed
    ..0. The most significant SNP was rs3764261, located 5'upstream of CETP, exhibiting a -log(10)P value of 6.17...
  60. Ruan X, Ma L, Wang S, Lindpaintner K, Liu X, Wang B, et al. TAQIB and I405V polymorphisms of CETP are moderately associated with obesity risk in the Chinese adult population. Acta Diabetol. 2010;47:217-24 pubmed publisher
    ..Adjustments for HDL levels completely (TAQIB) or partially (I405V) abolished the observed association. ..
  61. Teslovich T, Musunuru K, Smith A, Edmondson A, Stylianou I, Koseki M, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466:707-13 pubmed publisher
    ..Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD. ..
  62. Chaaba R, Smaoui M, Hammami S, Attia N, Ben Hamda K, Masmoudi A, et al. [Role of cholesteryl ester transfer protein activity and genetic polymorphism in ischemic heart disease in type 2 diabetic patients]. Tunis Med. 2004;82:282-8 pubmed
    b>Cholesteryl Ester Transfer Protein (CETP) facilates the exchange of triglycerides (TG) and cholesteryl ester between lipoproteins particles...
  63. Isaacs A, Aulchenko Y, Hofman A, Sijbrands E, Sayed Tabatabaei F, Klungel O, et al. Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels. J Clin Endocrinol Metab. 2007;92:2680-7 pubmed
    Polymorphisms in the hepatic lipase (LIPC -514C > T) and cholesteryl ester transfer protein (CETP I405V) genes affect high-density lipoprotein cholesterol (HDL-c) levels, but their relationship with cardiovascular disease and their ..
  64. Enquobahrie D, Smith N, Bis J, Carty C, Rice K, Lumley T, et al. Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke. Am J Cardiol. 2008;101:1683-8 pubmed publisher
    ..We investigated independent and joint associations of variations in cholesterol ester transfer protein (CETP), interleukin-8 (IL8), peroxisome proliferator activator receptor-alpha (PPARA), and Toll-like receptor 4 (TLR4) ..
  65. Plengpanich W, Le Goff W, Poolsuk S, Julia Z, Guerin M, Khovidhunkit W. CETP deficiency due to a novel mutation in the CETP gene promoter and its effect on cholesterol efflux and selective uptake into hepatocytes. Atherosclerosis. 2011;216:370-3 pubmed publisher
    To identify the genetic variant in the CETP gene of the proband with high HDL-C and low CETP activity and to investigate whether HDL from the CETP-deficient subject was dysfunctional in the reverse cholesterol transport (RCT) pathway.
  66. Soyal S, Sandhofer A, Hahne P, Oberkofler H, Felder T, Iglseder B, et al. Cholesteryl ester transfer protein and hepatic lipase gene polymorphisms: effects on hepatic mRNA levels, plasma lipids and carotid atherosclerosis. Atherosclerosis. 2011;216:374-80 pubmed publisher
    HDL modifying effects of cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) depend in part on each other...
  67. Tai E, Ordovas J, Corella D, Deurenberg Yap M, Chan E, Adiconis X, et al. The TaqIB and -629C>A polymorphisms at the cholesteryl ester transfer protein locus: associations with lipid levels in a multiethnic population. The 1998 Singapore National Health Survey. Clin Genet. 2003;63:19-30 pubmed
    ..We studied the TaqIB and -629C>A polymorphisms at the CETP locus in 1300 Chinese, 364 Malay and 282 Asian Indian men, and in 1558 Chinese, 397 Malay and 306 Asian Indian ..
  68. Zheng K, Zhang S, He Y, Zhang L, Zhang K, Huang D, et al. Association between cholesteryl ester transfer protein gene polymorphisms and variations in lipid levels in patients with coronary heart disease. Chin Med J (Engl). 2004;117:1288-92 pubmed
    The Taq/B, Msp/ and I405V polymorphisms of cholesteryl ester transfer protein (CETP), an important regulatory factor of lipid metabolism, have been attracted much more attention by the researchers...
  69. Hsieh M, Tien K, Chang S, Lo C, Hsin S, Hsiao J, et al. Cholesteryl ester transfer protein B1B1 genotype as a predictor of coronary artery disease in Taiwanese with type 2 diabetes mellitus. Metabolism. 2007;56:745-50 pubmed
    ..b>Cholesteryl ester transfer protein (CETP) gene TaqIB polymorphism is associated with lipid profile variability, and this polymorphism ..
  70. Novelli V, Viviani Anselmi C, Roncarati R, Guffanti G, Malovini A, Piluso G, et al. Lack of replication of genetic associations with human longevity. Biogerontology. 2008;9:85-92 pubmed
    ..We tested Klotho (KL)-VS variant (rs952706), Cholesteryl Ester Transfer Protein (CETP) I405V (rs5882), Paraoxonase 1 (PON1) Q192R (rs662), Apolipoprotein C-III (APOC3) -641C/A (..
  71. Chen W, Stambolian D, Edwards A, Branham K, Othman M, Jakobsdottir J, et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010;107:7401-6 pubmed publisher
    ..In addition, our data revealed strong association signals with alleles at two loci (LIPC, P = 1.3 x 10(-7); CETP, P = 7...
  72. Blankenberg S, Rupprecht H, Bickel C, Jiang X, Poirier O, Lackner K, et al. Common genetic variation of the cholesteryl ester transfer protein gene strongly predicts future cardiovascular death in patients with coronary artery disease. J Am Coll Cardiol. 2003;41:1983-9 pubmed
    We sought to evaluate the association between cholesteryl ester transfer protein (CETP) genotypes and the risk of future cardiovascular mortality in patients with coronary artery disease (CAD)...
  73. Bauerfeind A, Knoblauch H, Schuster H, Luft F, Reich J. Single nucleotide polymorphism haplotypes in the cholesteryl-ester transfer protein (CETP) gene and lipid phenotypes. Hum Hered. 2002;54:166-73 pubmed
    ..concentrations and family-derived haplotypes based on six common SNPs in the cholesteryl-ester transfer protein (CETP) gene. We based our analysis on 201 founders from families recruited throughout Germany...
  74. Blankenberg S, Tiret L, Bickel C, Schlitt A, Jungmair W, Genth Zotz S, et al. [Genetic variation of the cholesterol ester transfer protein gene and the prevalence of coronary artery disease. The AtheroGene case control study]. Z Kardiol. 2004;93 Suppl 4:IV16-23 pubmed
    Various functional polymorphisms of the cholesteryl ester transfer protein ( CETP) gene influence CETP activity and the concentration of high-density lipoprotein (HDL) cholesterol...
  75. Muendlein A, Saely C, Marte T, Schmid F, Koch L, Rein P, et al. Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 -482 C>T polymorphisms on their association with coronary artery disease. Atherosclerosis. 2008;199:179-86 pubmed publisher
    The single nucleotide polymorphisms (SNPs) apolipoprotein E (APOE) epsilon3/epsilon2/epsilon4, cholesteryl ester transfer protein (CETP) TaqIB, and apolipoprotein C3 (APOC3) -482 C>T have been associated with an atherogenic lipid ..
  76. Tsai M, Li N, Sharrett A, Shea S, Jacobs D, Tracy R, et al. Associations of genetic variants in ATP-binding cassette A1 and cholesteryl ester transfer protein and differences in lipoprotein subclasses in the multi-ethnic study of atherosclerosis. Clin Chem. 2009;55:481-8 pubmed publisher
    ATP-binding cassette A1 (ABCA1) and cholesteryl ester transfer protein (CETP) play important roles in the reverse cholesterol transport pathway...
  77. Poduri A, Khullar M, Bahl A, Sharma Y, Talwar K. A combination of proatherogenic single-nucleotide polymorphisms is associated with increased risk of coronary artery disease and myocardial infarction in Asian Indians. DNA Cell Biol. 2009;28:451-60 pubmed publisher
    ..Fifteen SNPs of CETP, ABCB1, APOAI, CYP7A1, and HMGCR genes were genotyped in 265 CAD patients and 150 controls of North Indian origin...
  78. Rejeb J, Omezzine A, Boumaiza I, Rebhi L, Rejeb N, Nabli N, et al. Four polymorphisms of cholesteryl ester transfer protein gene and coronary stenosis in a Tunisian population. J Cardiovasc Med (Hagerstown). 2012;13:546-53 pubmed publisher
    The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is under debate...
  79. Kotake H, Sekikawa A, Tokita Y, Ishigaki Y, Oikawa S. Effect of HMG-CoA reductase inhibitor on plasma cholesteryl ester transfer protein activity in primary hypercholesterolemia: comparison among CETP/TaqIB genotype subgroups. J Atheroscler Thromb. 2002;9:207-12 pubmed
    ..reductase inhibitors (statins) on the activity and concentration of plasma cholesterol ester transfer protein (CETP) in 30 hypercholesterolemic patients...
  80. Cazita P, Berti J, Aoki C, Gidlund M, Harada L, Nunes V, et al. Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice. J Lipid Res. 2003;44:33-40 pubmed
    ..Enhanced and diminished atherosclerosis have been associated with plasma levels of cholesteryl ester transfer protein (CETP); however, little is known about the role of CETP-ovarian hormone interactions in ..
  81. Zheng K, Zhang S, Zhang K, Zhang L, He Y, Kong X, et al. [Study on the association of cholesteryl ester transfer protein gene mutations with the susceptibility to coronary atherosclerotic heart disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20:23-6 pubmed
    To determine the frequencies of 4 mutations of cholesteryl ester transfer protein (CETP) gene in Chinese population and to investigate the association of the mutations with lipid metabolism and the susceptibility to coronary ..
  82. van Venrooij F, Stolk R, Banga J, Sijmonsma T, Van Tol A, Erkelens D, et al. Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in type 2 diabetes. Diabetes Care. 2003;26:1216-23 pubmed
    The cholesteryl ester transfer protein (CETP) plays a key role in the remodeling of triglyceride (TG)-rich and HDL particles...
  83. Skoglund Andersson C, Ehrenborg E, Fisher R, Olivecrona G, Hamsten A, Karpe F. Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men. Atherosclerosis. 2003;167:311-7 pubmed
    ..Common variants in the cholesteryl ester transfer protein (CETP-629C/A), lipoprotein lipase (LPL S447X), hepatic lipase (HL-480C/T) and apolipoprotein E (apoE ..
  84. Carlquist J, Muhlestein J, Horne B, Hart N, Bair T, Molhuizen H, et al. The cholesteryl ester transfer protein Taq1B gene polymorphism predicts clinical benefit of statin therapy in patients with significant coronary artery disease. Am Heart J. 2003;146:1007-14 pubmed
    b>Cholesteryl ester transfer protein (CETP) regulates plasma lipid distribution...
  85. Tobin M, Braund P, Burton P, Thompson J, Steeds R, Channer K, et al. Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study. Eur Heart J. 2004;25:459-67 pubmed
    ..The alpha-adducin 460trp variant (OR 0.73, 95% CI 0.59-0.91, P=0.006) and the cholesteryl ester transfer protein -629A variant (OR 0.82, 95% CI 0.68-0.97, P=0...
  86. Borggreve S, Hillege H, Wolffenbuttel B, de Jong P, Bakker S, van der Steege G, et al. The effect of cholesteryl ester transfer protein -629C->A promoter polymorphism on high-density lipoprotein cholesterol is dependent on serum triglycerides. J Clin Endocrinol Metab. 2005;90:4198-204 pubmed
    The -629C-->A cholesteryl ester transfer protein (CETP) promoter polymorphism is a determinant of HDL cholesterol (HDL-C)...
  87. Whiting B, Anderson J, Muhlestein J, Horne B, Bair T, Pearson R, et al. Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease. Am Heart J. 2005;150:243-50 pubmed
    ..Moderate-sized studies have suggested that variants of candidate genes can influence laboratory markers of coronary artery disease (CAD), but whether they predict parallel changes in clinical CAD risk is unknown...
  88. Stancakova A, Baldaufová L, Javorsky M, Kozarova M, Salagovic J, Tkac I. Effect of gene polymorphisms on lipoprotein levels in patients with dyslipidemia of metabolic syndrome. Physiol Res. 2006;55:483-90 pubmed
    ..To evaluate the influence of cholesterol ester transfer protein (CETP) TaqIB polymorphism, lipoprotein lipase (LPL) PvuII and HindIII polymorphisms, hepatic lipase (LIPC) G-250A ..
  89. Thompson J, Wood L, Pickering E, Dechairo B, Hyde C. High-density genotyping and functional SNP localization in the CETP gene. J Lipid Res. 2007;48:434-43 pubmed
    The cholesteryl ester transfer protein gene (CETP) has been the subject of hundreds of genetic analyses that typically focus on a small number of polymorphisms within a single ethnic group...
  90. Kolovou G, Anagnostopoulou K, Kostakou P, Marvaki C, Mihas C, Mikhailidis D, et al. Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia. Clin Chem Lab Med. 2007;45:1190-8 pubmed
    We examined the influence of cholesteryl ester transfer protein TaqIB polymorphism on triglyceride (TG) response to an oral fat tolerance test (OFTT) in patients heterozygous for familial hypercholesterolemia (hFH)...
  91. Jensen M, Mukamal K, Overvad K, Rimm E. Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women. Eur Heart J. 2008;29:104-12 pubmed
    To investigate whether a common polymorphism in the cholesteryl ester transfer protein (CETP) gene modifies the relationship of alcohol intake with high-density lipoprotein cholesterol (HDL-C) and risk of coronary heart disease (CHD)...
  92. Lira M, Loomis A, Paciga S, Lloyd D, Thompson J. Expression of CETP and of splice variants induces the same level of ER stress despite secretion efficiency differences. J Lipid Res. 2008;49:1955-62 pubmed publisher
    The cholesteryl ester transfer protein (CETP) gene has been associated with a variety of phenotypes, including HDL-cholesterol levels and, more sporadically, with cardiovascular disease, obesity, and extreme longevity...