CETP

Summary

Gene Symbol: CETP
Description: cholesteryl ester transfer protein
Alias: BPIFF, HDLCQ10, cholesteryl ester transfer protein, BPI fold containing family F, cholesteryl ester transfer protein plasma, lipid transfer protein I
Species: human
Products:     CETP

Top Publications

  1. Dergunov A, Shabrova E, Dobretsov G. Cholesteryl ester diffusion, location and self-association constraints determine CETP activity with discoidal HDL: excimer probe study. Arch Biochem Biophys. 2014;564:211-8 pubmed publisher
    The transfer of cholesteryl ester by recombinant cholesteryl ester transfer protein (CETP) between reconstituted discoidal high-density lipoprotein (rHDL) was studied...
  2. Westerterp M, van der Hoogt C, de Haan W, Offerman E, Dallinga Thie G, Jukema J, et al. Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice. Arterioscler Thromb Vasc Biol. 2006;26:2552-9 pubmed
    The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate...
  3. Spielmann N, Leon A, Rao D, Rice T, Skinner J, Bouchard C, et al. CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study. Physiol Genomics. 2007;31:25-31 pubmed
    Associations between cholesteryl ester transfer protein (CETP) polymorphisms and high-density lipoprotein cholesterol (HDL-c) levels before and after 20 wk of endurance training were investigated in the HERITAGE Family Study...
  4. Elosua R, Cupples L, Fox C, Polak J, D Agostino R, Wolf P, et al. Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study. Atherosclerosis. 2006;189:222-8 pubmed
    ..In multivariable, sex-specific analyses, the rare allele of the cholesterol ester transfer protein (CETP) TaqIB variant was associated with lower ICA IMT in men...
  5. Koropatnick T, Kimbell J, Chen R, Grove J, Donlon T, Masaki K, et al. A prospective study of high-density lipoprotein cholesterol, cholesteryl ester transfer protein gene variants, and healthy aging in very old Japanese-american men. J Gerontol A Biol Sci Med Sci. 2008;63:1235-40 pubmed
    High-density lipoprotein cholesterol (HDL-C) and cholesteryl ester transfer protein (CETP) gene deficiency mutations that increase HDL-C levels have been associated with exceptional longevity...
  6. Weissglas Volkov D, Aguilar Salinas C, Sinsheimer J, Riba L, Huertas Vazquez A, Ordoñez Sánchez M, et al. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. Circ Cardiovasc Genet. 2010;3:31-8 pubmed publisher
    ..These variants were within or near the genes ABCA1, ANGPTL3, APOA5, APOB, CETP, GALNT2, GCKR, LCAT, LIPC, LPL (2), MMAB-MVK, TRIB1, and XKR6-AMAC1L2...
  7. Chen D, Yang J, Tang Z, Dong X, Feng X, Yu S, et al. Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon4 in Chinese. Brain Res. 2008;1187:52-7 pubmed
    ..It is known that the levels of HDL are regulated by cholesteryl ester transfer protein (CETP) and several single nucleotide polymorphisms (SNPs) in the CETP gene have been shown to be ..
  8. Chambers J, Elliott P, Zabaneh D, Zhang W, Li Y, Froguel P, et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet. 2008;40:716-8 pubmed publisher
    ..Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance. ..
  9. Ruan X, Ma L, Wang S, Lindpaintner K, Liu X, Wang B, et al. TAQIB and I405V polymorphisms of CETP are moderately associated with obesity risk in the Chinese adult population. Acta Diabetol. 2010;47:217-24 pubmed publisher
    ..Adjustments for HDL levels completely (TAQIB) or partially (I405V) abolished the observed association. ..
  10. Teslovich T, Musunuru K, Smith A, Edmondson A, Stylianou I, Koseki M, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466:707-13 pubmed publisher
    ..Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD. ..

Detail Information

Publications97

  1. Dergunov A, Shabrova E, Dobretsov G. Cholesteryl ester diffusion, location and self-association constraints determine CETP activity with discoidal HDL: excimer probe study. Arch Biochem Biophys. 2014;564:211-8 pubmed publisher
    The transfer of cholesteryl ester by recombinant cholesteryl ester transfer protein (CETP) between reconstituted discoidal high-density lipoprotein (rHDL) was studied...
  2. Westerterp M, van der Hoogt C, de Haan W, Offerman E, Dallinga Thie G, Jukema J, et al. Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice. Arterioscler Thromb Vasc Biol. 2006;26:2552-9 pubmed
    The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate...
  3. Spielmann N, Leon A, Rao D, Rice T, Skinner J, Bouchard C, et al. CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study. Physiol Genomics. 2007;31:25-31 pubmed
    Associations between cholesteryl ester transfer protein (CETP) polymorphisms and high-density lipoprotein cholesterol (HDL-c) levels before and after 20 wk of endurance training were investigated in the HERITAGE Family Study...
  4. Elosua R, Cupples L, Fox C, Polak J, D Agostino R, Wolf P, et al. Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study. Atherosclerosis. 2006;189:222-8 pubmed
    ..In multivariable, sex-specific analyses, the rare allele of the cholesterol ester transfer protein (CETP) TaqIB variant was associated with lower ICA IMT in men...
  5. Koropatnick T, Kimbell J, Chen R, Grove J, Donlon T, Masaki K, et al. A prospective study of high-density lipoprotein cholesterol, cholesteryl ester transfer protein gene variants, and healthy aging in very old Japanese-american men. J Gerontol A Biol Sci Med Sci. 2008;63:1235-40 pubmed
    High-density lipoprotein cholesterol (HDL-C) and cholesteryl ester transfer protein (CETP) gene deficiency mutations that increase HDL-C levels have been associated with exceptional longevity...
  6. Weissglas Volkov D, Aguilar Salinas C, Sinsheimer J, Riba L, Huertas Vazquez A, Ordoñez Sánchez M, et al. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. Circ Cardiovasc Genet. 2010;3:31-8 pubmed publisher
    ..These variants were within or near the genes ABCA1, ANGPTL3, APOA5, APOB, CETP, GALNT2, GCKR, LCAT, LIPC, LPL (2), MMAB-MVK, TRIB1, and XKR6-AMAC1L2...
  7. Chen D, Yang J, Tang Z, Dong X, Feng X, Yu S, et al. Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon4 in Chinese. Brain Res. 2008;1187:52-7 pubmed
    ..It is known that the levels of HDL are regulated by cholesteryl ester transfer protein (CETP) and several single nucleotide polymorphisms (SNPs) in the CETP gene have been shown to be ..
  8. Chambers J, Elliott P, Zabaneh D, Zhang W, Li Y, Froguel P, et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet. 2008;40:716-8 pubmed publisher
    ..Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance. ..
  9. Ruan X, Ma L, Wang S, Lindpaintner K, Liu X, Wang B, et al. TAQIB and I405V polymorphisms of CETP are moderately associated with obesity risk in the Chinese adult population. Acta Diabetol. 2010;47:217-24 pubmed publisher
    ..Adjustments for HDL levels completely (TAQIB) or partially (I405V) abolished the observed association. ..
  10. Teslovich T, Musunuru K, Smith A, Edmondson A, Stylianou I, Koseki M, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466:707-13 pubmed publisher
    ..Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD. ..
  11. Enquobahrie D, Smith N, Bis J, Carty C, Rice K, Lumley T, et al. Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke. Am J Cardiol. 2008;101:1683-8 pubmed publisher
    ..We investigated independent and joint associations of variations in cholesterol ester transfer protein (CETP), interleukin-8 (IL8), peroxisome proliferator activator receptor-alpha (PPARA), and Toll-like receptor 4 (TLR4) ..
  12. Isaacs A, Aulchenko Y, Hofman A, Sijbrands E, Sayed Tabatabaei F, Klungel O, et al. Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels. J Clin Endocrinol Metab. 2007;92:2680-7 pubmed
    Polymorphisms in the hepatic lipase (LIPC -514C > T) and cholesteryl ester transfer protein (CETP I405V) genes affect high-density lipoprotein cholesterol (HDL-c) levels, but their relationship with cardiovascular disease and their ..
  13. Soyal S, Sandhofer A, Hahne P, Oberkofler H, Felder T, Iglseder B, et al. Cholesteryl ester transfer protein and hepatic lipase gene polymorphisms: effects on hepatic mRNA levels, plasma lipids and carotid atherosclerosis. Atherosclerosis. 2011;216:374-80 pubmed publisher
    HDL modifying effects of cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) depend in part on each other...
  14. Plengpanich W, Le Goff W, Poolsuk S, Julia Z, Guerin M, Khovidhunkit W. CETP deficiency due to a novel mutation in the CETP gene promoter and its effect on cholesterol efflux and selective uptake into hepatocytes. Atherosclerosis. 2011;216:370-3 pubmed publisher
    To identify the genetic variant in the CETP gene of the proband with high HDL-C and low CETP activity and to investigate whether HDL from the CETP-deficient subject was dysfunctional in the reverse cholesterol transport (RCT) pathway.
  15. Chen W, Stambolian D, Edwards A, Branham K, Othman M, Jakobsdottir J, et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010;107:7401-6 pubmed publisher
    ..In addition, our data revealed strong association signals with alleles at two loci (LIPC, P = 1.3 x 10(-7); CETP, P = 7...
  16. Novelli V, Viviani Anselmi C, Roncarati R, Guffanti G, Malovini A, Piluso G, et al. Lack of replication of genetic associations with human longevity. Biogerontology. 2008;9:85-92 pubmed
    ..We tested Klotho (KL)-VS variant (rs952706), Cholesteryl Ester Transfer Protein (CETP) I405V (rs5882), Paraoxonase 1 (PON1) Q192R (rs662), Apolipoprotein C-III (APOC3) -641C/A (..
  17. Blankenberg S, Tiret L, Bickel C, Schlitt A, Jungmair W, Genth Zotz S, et al. [Genetic variation of the cholesterol ester transfer protein gene and the prevalence of coronary artery disease. The AtheroGene case control study]. Z Kardiol. 2004;93 Suppl 4:IV16-23 pubmed
    Various functional polymorphisms of the cholesteryl ester transfer protein ( CETP) gene influence CETP activity and the concentration of high-density lipoprotein (HDL) cholesterol...
  18. Poduri A, Khullar M, Bahl A, Sharma Y, Talwar K. A combination of proatherogenic single-nucleotide polymorphisms is associated with increased risk of coronary artery disease and myocardial infarction in Asian Indians. DNA Cell Biol. 2009;28:451-60 pubmed publisher
    ..Fifteen SNPs of CETP, ABCB1, APOAI, CYP7A1, and HMGCR genes were genotyped in 265 CAD patients and 150 controls of North Indian origin...
  19. Bauerfeind A, Knoblauch H, Schuster H, Luft F, Reich J. Single nucleotide polymorphism haplotypes in the cholesteryl-ester transfer protein (CETP) gene and lipid phenotypes. Hum Hered. 2002;54:166-73 pubmed
    ..concentrations and family-derived haplotypes based on six common SNPs in the cholesteryl-ester transfer protein (CETP) gene. We based our analysis on 201 founders from families recruited throughout Germany...
  20. Tsai M, Li N, Sharrett A, Shea S, Jacobs D, Tracy R, et al. Associations of genetic variants in ATP-binding cassette A1 and cholesteryl ester transfer protein and differences in lipoprotein subclasses in the multi-ethnic study of atherosclerosis. Clin Chem. 2009;55:481-8 pubmed publisher
    ATP-binding cassette A1 (ABCA1) and cholesteryl ester transfer protein (CETP) play important roles in the reverse cholesterol transport pathway...
  21. Muendlein A, Saely C, Marte T, Schmid F, Koch L, Rein P, et al. Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 -482 C>T polymorphisms on their association with coronary artery disease. Atherosclerosis. 2008;199:179-86 pubmed publisher
    The single nucleotide polymorphisms (SNPs) apolipoprotein E (APOE) epsilon3/epsilon2/epsilon4, cholesteryl ester transfer protein (CETP) TaqIB, and apolipoprotein C3 (APOC3) -482 C>T have been associated with an atherogenic lipid ..
  22. Rejeb J, Omezzine A, Boumaiza I, Rebhi L, Rejeb N, Nabli N, et al. Four polymorphisms of cholesteryl ester transfer protein gene and coronary stenosis in a Tunisian population. J Cardiovasc Med (Hagerstown). 2012;13:546-53 pubmed publisher
    The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is under debate...
  23. Ritsch A, Scharnagl H, Eller P, Tancevski I, Duwensee K, Demetz E, et al. Cholesteryl ester transfer protein and mortality in patients undergoing coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study. Circulation. 2010;121:366-74 pubmed publisher
    The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still open to debate...
  24. Zhou Y, Yin R, Deng Y, Li Y, Wu J. Interactions between alcohol intake and the polymorphism of rs708272 on serum high-density lipoprotein cholesterol levels in the Guangxi Hei Yi Zhuang population. Alcohol. 2008;42:583-91 pubmed publisher
    Both alcohol consumption and the polymorphism of the cholesteryl ester transfer protein (CETP) TaqIB gene (rs708272) influence plasma high-density lipoprotein cholesterol (HDL-C) levels...
  25. Qureischie H, Heun R, Lutjohann D, Popp J, Jessen F, Ledschbor Frahnert C, et al. CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk. Brain Res. 2008;1232:1-6 pubmed publisher
    b>Cholesteryl ester transfer protein (CETP) is a component of the high density lipoprotein (HDL)...
  26. van Venrooij F, Stolk R, Banga J, Sijmonsma T, Van Tol A, Erkelens D, et al. Common cholesteryl ester transfer protein gene polymorphisms and the effect of atorvastatin therapy in type 2 diabetes. Diabetes Care. 2003;26:1216-23 pubmed
    The cholesteryl ester transfer protein (CETP) plays a key role in the remodeling of triglyceride (TG)-rich and HDL particles...
  27. Hassanzadeh T, Firoozrai M, Zonouz A, Zavarehee A, Paoli M. Taq1B polymorphism of cholesteryl ester transfer protein (CETP) gene in primary combined hyperlipidaemia. Indian J Med Res. 2009;129:293-8 pubmed
    b>Cholesteryl ester transfer protein (CETP) gene polymorphism is known to be associated with changes in lipid profiles...
  28. Ridker P, Pare G, Parker A, Zee R, Miletich J, Chasman D. Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study. Circ Cardiovasc Genet. 2009;2:26-33 pubmed publisher
    Recent trial data have challenged the hypothesis that cholesteryl ester transfer protein (CETP) and high-density lipoprotein cholesterol (HDL-C) have causal roles in atherothrombosis...
  29. Regieli J, Jukema J, Grobbee D, Kastelein J, Kuivenhoven J, Zwinderman A, et al. CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction. Eur Heart J. 2008;29:2792-9 pubmed publisher
    Inhibition of cholesteryl ester transfer protein (CETP) increases HDL-cholesterol. However, its combination with statins may increase mortality by factors incompletely understood...
  30. Zheng K, Zhang S, Zhang K, Zhang L, He Y, Kong X, et al. [Study on the association of cholesteryl ester transfer protein gene mutations with the susceptibility to coronary atherosclerotic heart disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20:23-6 pubmed
    To determine the frequencies of 4 mutations of cholesteryl ester transfer protein (CETP) gene in Chinese population and to investigate the association of the mutations with lipid metabolism and the susceptibility to coronary ..
  31. Corella D, Carrasco P, Amiano P, Arriola L, Chirlaque M, Huerta J, et al. Common cholesteryl ester transfer protein gene variation related to high-density lipoprotein cholesterol is not associated with decreased coronary heart disease risk after a 10-year follow-up in a Mediterranean cohort: Modulation by alcohol consumpti. Atherosclerosis. 2010;211:531-8 pubmed publisher
    Despite the consistent association between cholesteryl ester transfer protein (CETP) gene variation and plasma HDL-C, huge controversy still rages on its association with coronary heart disease (CHD)...
  32. Schierer A, Been L, Ralhan S, Wander G, Aston C, Sanghera D. Genetic variation in cholesterol ester transfer protein, serum CETP activity, and coronary artery disease risk in Asian Indian diabetic cohort. Pharmacogenet Genomics. 2012;22:95-104 pubmed publisher
    The role of cholesteryl ester transfer protein (CETP) in the metabolism of high-density lipoprotein cholesterol (HDL-C) is well studied but still controversial...
  33. Pachocka L, Włodarczyk M, Nowicka G, Kłosiewicz Latoszek L, Wolańska D, Stolarska I. [CETP gene TaqIB polymorphism and plasma lipids in patients with overweight and obesity]. Rocz Panstw Zakl Hig. 2012;63:149-54 pubmed
    ..The aim of our study was to assess the relationship between the CETP gene TaqI polymorphism and concentrations of selected parameters of lipid metabolism in patients with overweight ..
  34. Cazita P, Berti J, Aoki C, Gidlund M, Harada L, Nunes V, et al. Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice. J Lipid Res. 2003;44:33-40 pubmed
    ..Enhanced and diminished atherosclerosis have been associated with plasma levels of cholesteryl ester transfer protein (CETP); however, little is known about the role of CETP-ovarian hormone interactions in ..
  35. Kotake H, Sekikawa A, Tokita Y, Ishigaki Y, Oikawa S. Effect of HMG-CoA reductase inhibitor on plasma cholesteryl ester transfer protein activity in primary hypercholesterolemia: comparison among CETP/TaqIB genotype subgroups. J Atheroscler Thromb. 2002;9:207-12 pubmed
    ..reductase inhibitors (statins) on the activity and concentration of plasma cholesterol ester transfer protein (CETP) in 30 hypercholesterolemic patients...
  36. Borggreve S, Hillege H, Wolffenbuttel B, de Jong P, Bakker S, van der Steege G, et al. The effect of cholesteryl ester transfer protein -629C->A promoter polymorphism on high-density lipoprotein cholesterol is dependent on serum triglycerides. J Clin Endocrinol Metab. 2005;90:4198-204 pubmed
    The -629C-->A cholesteryl ester transfer protein (CETP) promoter polymorphism is a determinant of HDL cholesterol (HDL-C)...
  37. Thompson J, Wood L, Pickering E, Dechairo B, Hyde C. High-density genotyping and functional SNP localization in the CETP gene. J Lipid Res. 2007;48:434-43 pubmed
    The cholesteryl ester transfer protein gene (CETP) has been the subject of hundreds of genetic analyses that typically focus on a small number of polymorphisms within a single ethnic group...
  38. Tobin M, Braund P, Burton P, Thompson J, Steeds R, Channer K, et al. Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study. Eur Heart J. 2004;25:459-67 pubmed
    ..The alpha-adducin 460trp variant (OR 0.73, 95% CI 0.59-0.91, P=0.006) and the cholesteryl ester transfer protein -629A variant (OR 0.82, 95% CI 0.68-0.97, P=0...
  39. Stancakova A, Baldaufová L, Javorsky M, Kozarova M, Salagovic J, Tkac I. Effect of gene polymorphisms on lipoprotein levels in patients with dyslipidemia of metabolic syndrome. Physiol Res. 2006;55:483-90 pubmed
    ..To evaluate the influence of cholesterol ester transfer protein (CETP) TaqIB polymorphism, lipoprotein lipase (LPL) PvuII and HindIII polymorphisms, hepatic lipase (LIPC) G-250A ..
  40. Kolovou G, Anagnostopoulou K, Kostakou P, Marvaki C, Mihas C, Mikhailidis D, et al. Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia. Clin Chem Lab Med. 2007;45:1190-8 pubmed
    We examined the influence of cholesteryl ester transfer protein TaqIB polymorphism on triglyceride (TG) response to an oral fat tolerance test (OFTT) in patients heterozygous for familial hypercholesterolemia (hFH)...
  41. Carlquist J, Muhlestein J, Horne B, Hart N, Bair T, Molhuizen H, et al. The cholesteryl ester transfer protein Taq1B gene polymorphism predicts clinical benefit of statin therapy in patients with significant coronary artery disease. Am Heart J. 2003;146:1007-14 pubmed
    b>Cholesteryl ester transfer protein (CETP) regulates plasma lipid distribution...
  42. Whiting B, Anderson J, Muhlestein J, Horne B, Bair T, Pearson R, et al. Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease. Am Heart J. 2005;150:243-50 pubmed
    ..Moderate-sized studies have suggested that variants of candidate genes can influence laboratory markers of coronary artery disease (CAD), but whether they predict parallel changes in clinical CAD risk is unknown...
  43. Jensen M, Mukamal K, Overvad K, Rimm E. Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women. Eur Heart J. 2008;29:104-12 pubmed
    To investigate whether a common polymorphism in the cholesteryl ester transfer protein (CETP) gene modifies the relationship of alcohol intake with high-density lipoprotein cholesterol (HDL-C) and risk of coronary heart disease (CHD)...
  44. Skoglund Andersson C, Ehrenborg E, Fisher R, Olivecrona G, Hamsten A, Karpe F. Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men. Atherosclerosis. 2003;167:311-7 pubmed
    ..Common variants in the cholesteryl ester transfer protein (CETP-629C/A), lipoprotein lipase (LPL S447X), hepatic lipase (HL-480C/T) and apolipoprotein E (apoE ..
  45. Lira M, Loomis A, Paciga S, Lloyd D, Thompson J. Expression of CETP and of splice variants induces the same level of ER stress despite secretion efficiency differences. J Lipid Res. 2008;49:1955-62 pubmed publisher
    The cholesteryl ester transfer protein (CETP) gene has been associated with a variety of phenotypes, including HDL-cholesterol levels and, more sporadically, with cardiovascular disease, obesity, and extreme longevity...
  46. Frisdal E, Klerkx A, Le Goff W, Tanck M, Lagarde J, Jukema J, et al. Functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms in the CETP gene is a major determinant of promoter activity and plasma CETP concentration in the REGRESS Study. Hum Mol Genet. 2005;14:2607-18 pubmed
    b>Cholesteryl ester transfer protein (CETP) plays a key role in the determination of high-density lipoprotein (HDL) levels via its action on intravascular HDL metabolism...
  47. Middelberg R, Ferreira M, Henders A, Heath A, Madden P, Montgomery G, et al. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. BMC Med Genet. 2011;12:123 pubmed publisher
    ..Our study demonstrated the usefulness of examining multiple phenotypes jointly and highlights an anomalous effect on CRP, which is increasingly recognised as a marker of cardiovascular risk as well as of inflammation. ..
  48. Parra E, Urban A, Panzoldo N, Nakamura R, Oliveira R, de Faria E. A reduction of CETP activity, not an increase, is associated with modestly impaired postprandial lipemia and increased HDL-cholesterol in adult asymptomatic women. Lipids Health Dis. 2011;10:87 pubmed publisher
    The relationship between CETP and postprandial hyperlipemia is still unclear. We verified the effects of varying activities of plasma CETP on postprandial lipemia and precocious atherosclerosis in asymptomatic adult women...
  49. Fiegenbaum M, da Silveira F, Van der Sand C, Van der Sand L, Ferreira M, Pires R, et al. Pharmacogenetic study of apolipoprotein E, cholesteryl ester transfer protein and hepatic lipase genes and simvastatin therapy in Brazilian subjects. Clin Chim Acta. 2005;362:182-8 pubmed
    ..Polymorphisms in apolipoprotein E (APOE), cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC), proteins with major roles in lipid metabolism and homeostasis have ..
  50. Huang Y, Wu Y, Liu R, Fan P, Zhang J, Wang F, et al. Differential effect of ATP binding cassette transporter A1 R219K and cholesteryl ester transfer protein TaqIB genotypes on HDL-C levels in overweight/obese and non-obese Chinese subjects. Acta Cardiol. 2011;66:231-7 pubmed
    ATP-binding cassette transporter A1 (ABCA1) and cholesteryl ester transfer protein (CETP) are involved in the HDL metabolism and play a key role in reverse cholesterol transport...
  51. Zee R, Cook N, Cheng S, Erlich H, Lindpaintner K, Ridker P. Multi-locus candidate gene polymorphisms and risk of myocardial infarction: a population-based, prospective genetic analysis. J Thromb Haemost. 2006;4:341-8 pubmed
    ..a gly460trp polymorphism in the alpha-adducin gene, and a -629C>A polymorphism in the cholesteryl ester transfer protein gene with risk of MI...
  52. Padmaja N, Ravindra Kumar M, Soya S, Adithan C. Common variants of Cholesteryl ester transfer protein gene and their association with lipid parameters in healthy volunteers of Tamilian population. Clin Chim Acta. 2007;375:140-6 pubmed
    b>Cholesteryl ester transfer protein (CETP) is involved in a key pathway of reverse cholesterol transport implicated in atherosclerosis and coronary heart disease...
  53. Clifford A, Rincon G, Owens J, Medrano J, Moshfegh A, Baer D, et al. Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults. Lipids Health Dis. 2013;12:66 pubmed publisher
    ..Statistically significant SNP (where P values were adjusted for false discovery rate) included: CETP (rs7499892 and rs5882); SLC46A1 (rs37514694; rs739439); SLC19A1 (rs3788199); CD36 (rs3211956); BCMO1 (rs6564851), ..
  54. Sanders A, Wang C, Katz M, Derby C, Barzilai N, Ozelius L, et al. Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia. JAMA. 2010;303:150-8 pubmed publisher
    Polymorphisms in the cholesteryl ester transfer protein (CETP) gene have been associated with exceptional longevity and lower cardiovascular risk, but associations with memory decline and dementia risk are unclear...
  55. Thompson A, Di Angelantonio E, Sarwar N, Erqou S, Saleheen D, Dullaart R, et al. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA. 2008;299:2777-88 pubmed publisher
    The importance of the cholesteryl ester transfer protein (CETP) pathway in coronary disease is uncertain. Study of CETP genotypes can help better understand the relevance of this pathway to lipid metabolism and disease risk...
  56. Dullaart R, Sluiter W. Common variation in the CETP gene and the implications for cardiovascular disease and its treatment: an updated analysis. Pharmacogenomics. 2008;9:747-63 pubmed publisher
    Human plasma contains cholesteryl ester transfer protein (CETP) which, besides other functions, enables the transfer of cholesteryl esters in plasma from high-density lipoproteins (HDL) towards triglyceride-rich lipoproteins, thereby ..
  57. Ai M, Tanaka A, Shimokado K, Ohtani R, Inazu A, Kobayashi J, et al. A deficiency of cholesteryl ester transfer protein whose serum remnant-like particle-triglyceride significantly increased, but serum remnant-like particle-cholesterol did not after an oral fat load. Ann Clin Biochem. 2009;46:457-63 pubmed publisher
    We found a unique cholesteryl ester transfer protein (CETP) deficient case with markedly elevated serum triglyceride (TG) as well as high-density lipoprotein cholesterol (HDL-C) levels...
  58. Van Eck M, Ye D, Hildebrand R, Kar Kruijt J, de Haan W, Hoekstra M, et al. Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice. Circ Res. 2007;100:678-85 pubmed
    Abundant amounts of cholesteryl ester transfer protein (CETP) are found in macrophage-derived foam cells in the arterial wall, but its function in atherogenesis is unknown...
  59. Meiner V, Friedlander Y, Milo H, Sharon N, Ben Avi L, Shpitzen S, et al. Cholesteryl ester transfer protein (CETP) genetic variation and early onset of non-fatal myocardial infarction. Ann Hum Genet. 2008;72:732-41 pubmed publisher
    Although Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl esters and triglycerides between lipoprotein particles and thus plays a crucial role in reverse cholesterol transport, the association of variations ..
  60. Izar M, Helfenstein T, Ihara S, Relvas W, Santos A, Fischer S, et al. Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study. Atherosclerosis. 2009;204:165-70 pubmed publisher
    ..APO A1 (A/G -75 and C/T +83) and APO C3 (C/G 3'UTR) non-coding sequences, CETP (Taq 1B), LPL (D9N), APO E (epsilon2, epsilon3, epsilon4,), PON-1 (Q192R), and two LCAT variants Arg(147)-->Trp ..
  61. Rotllan N, Calpe Berdiel L, Guillaumet Adkins A, Suren Castillo S, Blanco Vaca F, Escola Gil J. CETP activity variation in mice does not affect two major HDL antiatherogenic properties: macrophage-specific reverse cholesterol transport and LDL antioxidant protection. Atherosclerosis. 2008;196:505-13 pubmed
    b>CETP inhibition increases HDL cholesterol levels and presumably could contribute to human atheroprotection via increasing macrophage-specific reverse cholesterol transport (RCT) and antioxidant properties of HDL...
  62. Weitgasser R, Galvan G, Malaimare L, Derflinger I, Hedegger M, Lang J, et al. Cholesteryl ester transfer protein TaqIB polymorphism and its relation to parameters of the insulin resistance syndrome in an Austrian cohort. Biomed Pharmacother. 2004;58:619-27 pubmed
    The cholesteryl ester transfer protein (CETP) is responsible for the exchange of triglycerides and cholesteryl esters between lipoprotein particles leading to an increased hepatic clearance of HDL-cholesteryl esters...
  63. Rejeb J, Omezzine A, Rebhi L, Naffeti I, Kchok K, Belkahla R, et al. Association of the cholesteryl ester transfer protein Taq1 B2B2 genotype with higher high-density lipoprotein cholesterol concentrations and lower risk of coronary artery disease in a Tunisian population. Arch Cardiovasc Dis. 2008;101:629-36 pubmed publisher
    The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is undergoing debate...
  64. Barter P, Brewer H, Chapman M, Hennekens C, Rader D, Tall A. Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler Thromb Vasc Biol. 2003;23:160-7 pubmed
    b>Cholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters from antiatherogenic HDLs to proatherogenic apolipoprotein B (apoB)-containing lipoproteins, including VLDLs, VLDL remnants, IDLs, and LDLs...
  65. Plengpanich W, Siriwong S, Khovidhunkit W. Two novel mutations and functional analyses of the CETP and LIPC genes underlying severe hyperalphalipoproteinemia. Metabolism. 2009;58:1178-84 pubmed publisher
    ..We investigated whether activities in cholesteryl ester transfer protein (CETP) and hepatic lipase (HL) contribute to HALP in the Thai population and performed genetic ..
  66. Porchay Baldérelli I, Pean F, Bellili N, Jaziri R, Marre M, Fumeron F. The CETP TaqIB polymorphism is associated with the risk of sudden death in type 2 diabetic patients. Diabetes Care. 2007;30:2863-7 pubmed
    ..This cardiovascular risk can be partly attributed to low levels of HDL cholesterol. The B2 allele of the CETP TaqIB polymorphism has been repeatedly reported to be associated with high HDL cholesterol levels in both healthy ..
  67. Ahmad T, Chasman D, Buring J, Lee I, Ridker P, Everett B. Physical activity modifies the effect of LPL, LIPC, and CETP polymorphisms on HDL-C levels and the risk of myocardial infarction in women of European ancestry. Circ Cardiovasc Genet. 2011;4:74-80 pubmed publisher
    ..for rs10096633 at lipoprotein lipase (LPL), rs1800588 at hepatic lipase (LIPC), and rs1532624 at cholesteryl ester transfer protein (CETP) (each P-interaction<0.05)...
  68. Zhu H, Gopalraj R, Kelly J, Bennett D, Estus S. Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease. Neurosci Lett. 2005;381:36-41 pubmed
    ..Recently, several single nucleotide polymorphisms (SNPs) in cholesteryl ester transfer protein (CETP) were associated with altered plasma CETP concentrations, cholesterol concentrations and CAD...
  69. Padmaja N, Kumar R, Balachander J, Adithan C. Cholesteryl ester transfer protein TaqIB, -629C>A and I405V polymorphisms and risk of coronary heart disease in an Indian population. Clin Chim Acta. 2009;402:139-45 pubmed publisher
    ..matched by age and gender, belonging to the Tamilian population of south India were genotyped for polymorphisms in CETP gene using PCR RFLP methods...
  70. Ksiazek J, Ciechanowicz A, Wierzbicka A, Syczewska M, Grenda R. Is dyslipidemia sustained during remission of nephrotic syndrome genetically determined? Evaluation of genetic polymorphisms of proteins involved in lipoprotein metabolism in children and adolescents with nephrotic syndrome. Pol Arch Med Wewn. 2009;119:11-6 pubmed
    ..In same patients lipid profile disturbances persist during nephrotic syndrome remission...
  71. Ruan X, Ma L, Wang S, Lindpaintner K, Liu X, Wang B, et al. Association of two CETP polymorphisms with HDL levels in the Chinese obese population. Obesity (Silver Spring). 2009;17:2196-201 pubmed publisher
    The association of two cholesterol ester transfer protein (CETP) polymorphisms, D442G and TAQIB (B1-->B2), with high-density lipoprotein (HDL) levels in 932 Chinese obese individuals (BMI >or= 27) was investigated in comparison with ..
  72. Keavney B, Palmer A, Parish S, Clark S, Youngman L, Danesh J, et al. Lipid-related genes and myocardial infarction in 4685 cases and 3460 controls: discrepancies between genotype, blood lipid concentrations, and coronary disease risk. Int J Epidemiol. 2004;33:1002-13 pubmed
    ..The B2 allele of the cholesteryl ester transfer protein TaqIb polymorphism was associated with a significantly lower plasma apoB/apoA(1) ratio, but with no ..
  73. Marques Vidal P, Bochud M, Paccaud F, Waterworth D, Bergmann S, Preisig M, et al. No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels. Atherosclerosis. 2010;211:551-7 pubmed publisher
    ..To assess the relationships and possible interactions between polymorphisms related to HDL levels and alcohol consumption...
  74. Takata M, Inazu A, Katsuda S, Miwa K, Kawashiri M, Nohara A, et al. CETP (cholesteryl ester transfer protein) promoter -1337 C>T polymorphism protects against coronary atherosclerosis in Japanese patients with heterozygous familial hypercholesterolaemia. Clin Sci (Lond). 2006;111:325-31 pubmed
    CETP (cholesteryl ester transfer protein) and HL (hepatic lipase) play a role in the metabolism of plasma lipoproteins, but the effects of CETP and LIPC (gene encoding HL) genotypes on coronary atherosclerosis may be dependent on LDL (low-..
  75. Ma L, Yang J, Runesha H, Tanaka T, Ferrucci L, Bandinelli S, et al. Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data. BMC Med Genet. 2010;11:55 pubmed publisher
    ..For HDL-C, LPL was confirmed by 12 SNPs 8-45 kb downstream, CETP by two SNPs 0.5-11 kb upstream, and the LIPG-ACAA2 region by five SNPs inside this region...
  76. Kolovou G, Stamatelatou M, Anagnostopoulou K, Kostakou P, Kolovou V, Mihas C, et al. Cholesteryl ester transfer protein gene polymorphisms and longevity syndrome. Open Cardiovasc Med J. 2010;4:14-9 pubmed publisher
    ..Since HDL particles are influenced by cholesteryl ester transfer protein (CETP) activity, it is worth studying the CETP polymorphism...
  77. Kaestner S, Patsouras N, Spathas D, Flordellis C, Manolis A. Lack of association between the cholesteryl ester transfer protein gene--TaqIB polymorphism and coronary restenosis following percutaneous transluminal coronary angioplasty and stenting: a pilot study. Angiology. 2010;61:338-43 pubmed publisher
    The most widely studied variation at the cholesteryl ester transfer protein (CETP) gene locus is a silent base change called the Thermobius aquaticus IB (TaqIB) polymorphism...
  78. McCaskie P, Beilby J, Chapman C, Hung J, McQuillan B, Thompson P, et al. Cholesteryl ester transfer protein gene haplotypes, plasma high-density lipoprotein levels and the risk of coronary heart disease. Hum Genet. 2007;121:401-11 pubmed
    ..b>Cholesteryl ester transfer protein (CETP) is a key protein in HDL-C metabolism such that elevated CETP activity is associated with ..