CEP55

Summary

Gene Symbol: CEP55
Description: centrosomal protein 55
Alias: C10orf3, CT111, MARCH, URCC6, centrosomal protein of 55 kDa, cancer/testis antigen 111, centrosomal protein 55kDa, up-regulated in colon cancer 6
Species: human
Products:     CEP55

Top Publications

  1. Lee H, Elia N, Ghirlando R, Lippincott Schwartz J, Hurley J. Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science. 2008;322:576-80 pubmed publisher
    ..the ESCRT-associated protein ALIX to the midbody (the structure that tethers two daughter cells) by the protein CEP55. Biochemical experiments show that peptides from ALIX and the ESCRT-I subunit TSG101 compete for binding to the ..
  2. Martinez Garay I, Rustom A, Gerdes H, Kutsche K. The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody. Genomics. 2006;87:243-53 pubmed
    ..Here we describe the molecular characterization of a novel human gene, CEP55, located in 10q23.33 that is expressed in multiple tissues and various cancer cell lines...
  3. Zhao W, Seki A, Fang G. Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis. Mol Biol Cell. 2006;17:3881-96 pubmed
    ..Through this analysis, we identified Cep55 as a regulator required for the completion of cytokinesis...
  4. Chen C, Lu P, Chen Y, Fu S, Wu K, Tsou A, et al. FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway. Oncogene. 2007;26:4272-83 pubmed
    ..These findings may contribute to the development of new therapeutic strategies that are able to block the PI3K/AKT pathway in cancer cells. ..
  5. Carlton J, Agromayor M, Martin Serrano J. Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release. Proc Natl Acad Sci U S A. 2008;105:10541-6 pubmed publisher
    ..we show that the ESCRT-III-binding protein Alix is recruited to the midbody of dividing cells through binding Cep55 via an evolutionarily conserved peptide...
  6. Fabbro M, Zhou B, Takahashi M, Sarcevic B, Lal P, Graham M, et al. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev Cell. 2005;9:477-88 pubmed
    ..Here, we describe a human coiled-coil protein, Cep55 (centrosome protein 55 kDa), that localizes to the mother centriole during interphase...
  7. van der Horst A, Simmons J, Khanna K. Cep55 stabilization is required for normal execution of cytokinesis. Cell Cycle. 2009;8:3742-9 pubmed
    b>Cep55 is a mitotic phosphoprotein that plays an important role in cytokinesis, the final stage of cell division during which physical separation of the two daughter cells is accomplished...
  8. van der Horst A, Khanna K. The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55. Cancer Res. 2009;69:6651-9 pubmed publisher
    ..to the midbody ring and regulates the final stages of cytokinesis by binding to centrosome protein 55 kDa (Cep55), an essential component of this ring...
  9. Carlton J, Martin Serrano J. Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. Science. 2007;316:1908-12 pubmed
    ..protein-were recruited to the midbody during cytokinesis by interaction with centrosome protein 55 (Cep55), a centrosome and midbody protein essential for abscission...

More Information

Publications71

  1. Morita E, Sandrin V, Chung H, Morham S, Gygi S, Rodesch C, et al. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J. 2007;26:4215-27 pubmed
    ..analyses revealed that ALIX and TSG101/ESCRT-I also bind a series of proteins involved in cytokinesis, including CEP55, CD2AP, ROCK1, and IQGAP1...
  2. Chen C, Chien C, Huang C, Hwang C, Chuang H, Fang F, et al. Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity. Oncogene. 2009;28:2723-37 pubmed publisher
    ..These findings suggest that FLJ10540 is not only an important prognostic factor but also a new therapeutic target in the FLJ10540/FOXM1/MMP-2 pathway for OCSCC treatment. ..
  3. Hauptman N, Jevsinek Skok D, Spasovska E, Bostjancic E, Glavac D. Genes CEP55, FOXD3, FOXF2, GNAO1, GRIA4, and KCNA5 as potential diagnostic biomarkers in colorectal cancer. BMC Med Genomics. 2019;12:54 pubmed publisher
    ..After performing pathway and functional analysis on differentially expressed genes, we selected six genes: CEP55, FOXD3, FOXF2, GNAO1, GRIA4 and KCNA5, for further experimental validation on our own clinical samples...
  4. Li F, Jin D, Guan L, Zhang C, Wu T, Wang Y, et al. CEP55 promoted the migration, invasion and neuroshpere formation of the glioma cell line U251. Neurosci Lett. 2019;: pubmed publisher
    ..Centrosomal protein of 55 kDa (CEP55) was a biomarker for multiple cancers...
  5. Khalid M, Idichi T, Seki N, Wada M, Yamada Y, Fukuhisa H, et al. Gene Regulation by Antitumor miR-204-5p in Pancreatic Ductal Adenocarcinoma: The Clinical Significance of Direct RACGAP1 Regulation. Cancers (Basel). 2019;11: pubmed publisher
    ..Moreover, downstream genes affected by RACGAP1 (e.g., MMP28, CEP55, CDK1, ANLN and S100A14) are involved in PDAC pathogenesis...
  6. Hwang C, Shiu L, Su L, Yu Fang Yin -, Wang W, Huang S, et al. Oncogenic fibulin-5 promotes nasopharyngeal carcinoma cell metastasis through the FLJ10540/AKT pathway and correlates with poor prognosis. PLoS ONE. 2013;8:e84218 pubmed publisher
    ..Higher fibulin-5 expression is not only an important indicator of poor survival, but also contributes to the development of new therapeutic strategies in the FLJ10540/AKT pathway for NPC treatment. ..
  7. Rawlins L, Jones H, Wenger O, Aye M, Fasham J, Harlalka G, et al. An Amish founder variant consolidates disruption of CEP55 as a cause of hydranencephaly and renal dysplasia. Eur J Hum Genet. 2019;27:657-662 pubmed publisher
    The centrosomal protein 55 kDa (CEP55 (OMIM 610000)) plays a fundamental role in cell cycle regulation and cytokinesis. However, the precise role of CEP55 in human embryonic growth and development is yet to be fully defined...
  8. You B, Zhang K. MicroRNA-144-3p inhibits cell proliferation and promotes apoptosis in castration-resistant prostate cancer by targeting CEP55. Eur Rev Med Pharmacol Sci. 2018;22:7660-7670 pubmed publisher
    ..Additionally, miR-144-3p directly targeted centrosomal protein 55 (CEP55) and suppressed CEP55 expression...
  9. Rahane C, Kutzner A, Heese K. A cancer tissue-specific FAM72 expression profile defines a novel glioblastoma multiform (GBM) gene-mutation signature. J Neurooncol. 2019;141:57-70 pubmed publisher
    ..in cancer cells, specifically correlating with the mitotic cell cycle genes ASPM, KIF14, KIF23, CENPE, CENPE, CEP55, SGO1, and BUB1, thereby contributing to centrosome and mitotic spindle formation...
  10. Yue C, Ren Y, Ge H, Liang C, Xu Y, Li G, et al. Comprehensive analysis of potential prognostic genes for the construction of a competing endogenous RNA regulatory network in hepatocellular carcinoma. Onco Targets Ther. 2019;12:561-576 pubmed publisher
    ..were 13 key potential prognostic genes in the ceRNA regulatory network: eleven upregulated genes (CCNB1, CEP55, CHEK1, EZH2, KPNA2, LRRC1, PBK, RRM2, SLC7A11, SUCO, ..
  11. Seyedabadi S, Saidijam M, Najafi R, Mousavi Bahar S, Jafari M, MohammadGanji S, et al. Assessment of CEP55, PLK1 and FOXM1 expression in patients with bladder cancer in comparison with healthy individuals. Cancer Invest. 2018;36:407-414 pubmed publisher
    This case/control study is aimed at investigating the expression of CEP55, PLK1 and FOXM1 in bladder cancer tissues and comparing it with healthy tissue and their relationship with clinicopathological features of BC...
  12. Wu S, Wu D, Pan Y, Liu H, Shao Z, Wang M. Correlation between EZH2 and CEP55 and lung adenocarcinoma prognosis. Pathol Res Pract. 2019;215:292-301 pubmed publisher
    ..GSE66836 chip data were negatively correlated with methylation and expression changes, and centrosomal protein 55 (CEP55) was identified as the EZH2 downstream regulation candidate gene...
  13. Qadir F, Aziz M, Sari C, Ma H, Dai H, Wang X, et al. Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation. Mol Cancer. 2018;17:97 pubmed publisher
    ..We have also identified CEP55 as a potential cancer exosomal marker...
  14. Yang Y, Zhang M, Tian Q, Fu J, Yang X, Zhang C, et al. SPAG5 interacts with CEP55 and exerts oncogenic activities via PI3K/AKT pathway in hepatocellular carcinoma. Mol Cancer. 2018;17:117 pubmed publisher
    ..SPAG5 interacted with centrosomal protein CEP55 to trigger the phosphorylation of AKT at Ser473...
  15. Jeffery J, Neyt C, Moore W, Paterson S, Bower N, Chenevix Trench G, et al. Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish. FASEB J. 2015;29:1999-2009 pubmed publisher
    b>CEP55 was initially described as a centrosome- and midbody-associated protein and a key mediator of cytokinesis. More recently, it has been implicated in PI3K/AKT pathway activation via an interaction with the catalytic subunit of PI3K...
  16. Jia Y, Xiao Z, Gongsun X, Xin Z, Shang B, Chen G, et al. CEP55 promotes the proliferation, migration and invasion of esophageal squamous cell carcinoma via the PI3K/Akt pathway. Onco Targets Ther. 2018;11:4221-4232 pubmed publisher
    Centrosomal protein 55 (CEP55) is an important prognostic biomarker that plays an essential role in the proliferation, migration and invasion of multiple tumors...
  17. Schiewek J, Schumacher U, Lange T, Joosse S, Wikman H, Pantel K, et al. Clinical relevance of cytoskeleton associated proteins for ovarian cancer. J Cancer Res Clin Oncol. 2018;144:2195-2205 pubmed publisher
    ..proteins that participate in cancer disease progression and cytoskeleton modulation: KIF14, KIF20A, KIF18A, ASPM, CEP55, DLGAP5, MAP9, EB1, KATNA1, DIAPH1, ANLN, SCIN, CCDC88A, FSCN1, GSN, VASP and CDC42...
  18. Kalimutho M, Sinha D, Jeffery J, Nones K, Srihari S, Fernando W, et al. CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Mol Med. 2018;10: pubmed publisher
    The centrosomal protein, CEP55, is a key regulator of cytokinesis, and its overexpression is linked to genomic instability, a hallmark of cancer. However, the mechanism by which it mediates genomic instability remains elusive...
  19. de Carcer G, Venkateswaran S, Salgueiro L, El Bakkali A, Somogyi K, Rowald K, et al. Plk1 overexpression induces chromosomal instability and suppresses tumor development. Nat Commun. 2018;9:3012 pubmed publisher
    ..Mechanistically, these cytokinesis defects correlate with defective loading of Cep55 and ESCRT complexes to the abscission bridge, in a Plk1 kinase-dependent manner...
  20. Hsu W, Chang C, Huang K, Chen Y, Hsu S, Wu L, et al. Evaluation of the medicinal herb Graptopetalum paraguayense as a treatment for liver cancer. PLoS ONE. 2015;10:e0121298 pubmed publisher
    ..These results indicate that GP extracts and HH-F3 can protect the liver by suppressing tumor growth; consequently, these compounds could be considered for the treatment of HCC. ..
  21. Gao K, Zhang Y, Shi Q, Zhang J, Zhang L, Sun H, et al. iASPP-PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation. Cell Death Dis. 2018;9:528 pubmed publisher
    ..We found that iASPP associates with centrosomal protein of 55?kDa (CEP55), an important cytokinetic abscission regulator...
  22. Bondeson M, Ericson K, Gudmundsson S, Ameur A, Ponten F, Wesstrom J, et al. A nonsense mutation in CEP55 defines a new locus for a Meckel-like syndrome, an autosomal recessive lethal fetal ciliopathy. Clin Genet. 2017;92:510-516 pubmed publisher
    ..WES lead to identification of a homozygous nonsense mutation c.256C>T (p.Arg86*) in CEP55 (centrosomal protein of 55 kDa) in the affected fetus...
  23. Liu X, Zhang L, Liu Y, Cui J, Che S, An X, et al. Circ-8073 regulates CEP55 by sponging miR-449a to promote caprine endometrial epithelial cells proliferation via the PI3K/AKT/mTOR pathway. Biochim Biophys Acta Mol Cell Res. 2018;1865:1130-1147 pubmed publisher
    ..Circ-8073 binding to the target site of miR-449a had a negative feedback relationship. Centrosomal protein55 (CEP55) was a direct target gene of miR-449a, and Circ-8073 could increase the expression levels of CEP55 by sponging miR-..
  24. Jiang C, Zhang Y, Li Y, Lu J, Huang Q, Xu R, et al. High CEP55 expression is associated with poor prognosis in non-small-cell lung cancer. Onco Targets Ther. 2018;11:4979-4990 pubmed publisher
    Lung cancer is the most common and lethal malignancy worldwide. CEP55 was found to be overexpressed in multiple types of cancer...
  25. Li M, Gao J, Li D, Yin Y. CEP55 Promotes Cell Motility via JAK2?STAT3?MMPs Cascade in Hepatocellular Carcinoma. Cells. 2018;7: pubmed publisher
    ..Novel diagnostic or prognostic biomarkers and potential therapeutic targets for HCC are thus urgently needed. CEP55 plays a crucial role in regulating physical cytokinesis...
  26. Tsai C, Dai K, Fang C, Wu J, Chan S. PTEN/FLJ10540/PI3K/Akt cascade in experimental brain stem death: A newfound role for a classical tumorigenic signaling pathway. Biochem Pharmacol. 2018;155:207-212 pubmed publisher
    ..It promulgates the concept that rather than focusing on a particular disease condition, a new vista for future therapeutic strategy against both fatal eventualities should target at this common cellular cascade. ..
  27. Alonso S, Mayol X, Nonell L, Salvans S, Pascual M, Pera M. Peripheral blood leucocytes show differential expression of tumour progression-related genes in colorectal cancer patients who have a postoperative intra-abdominal infection: a prospective matched cohort study. Colorectal Dis. 2017;19:O115-O125 pubmed publisher
    ..Infection also upregulated some proangiogenic genes (CEP55, TRPS1) and downregulated some inhibitors of angiogenesis (MME, ALOX15, CXCL10)...
  28. Kim H, Yoon J, Matsuura A, Na J, Lee W, Kim H, et al. Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells. Proc Natl Acad Sci U S A. 2015;112:12372-7 pubmed publisher
    ..structures of the EABR [endosomal sorting complex required for transport (ESCRT) and ALIX-binding region] of CEP55 bound to the TEX14 peptide (or its chimeric peptides) and performed functional characterization of the CEP55-TEX14 ..
  29. Xu Z, Ma X, Qi S, Wang Z, Guo L, Schatten H, et al. Cep55 regulates spindle organization and cell cycle progression in meiotic oocyte. Sci Rep. 2015;5:16978 pubmed publisher
    b>Cep55 is a relatively novel member of the centrosomal protein family. Here, we show that Cep55 is expressed in mouse oocytes from the germinal vesicle (GV) to metaphase II (MII) stages...
  30. Johnsson M, Henriksen R, Höglund A, Fogelholm J, Jensen P, Wright D. Genetical genomics of growth in a chicken model. BMC Genomics. 2018;19:72 pubmed publisher
    ..Of these, the genes TRAK1, OSBPL8, YEATS4, CEP55, and PIP4K2B are identified as strong candidates for growth loci in the chicken...
  31. Li F, Jin D, Tang C, Gao D. CEP55 promotes cell proliferation and inhibits apoptosis via the PI3K/Akt/p21 signaling pathway in human glioma U251 cells. Oncol Lett. 2018;15:4789-4796 pubmed publisher
    Human glioma is one of the major malignancies worldwide with an increased mortality rate. Centrosomal protein of 55 kDa (CEP55) is an essential component of the CEP family and has been identified as a prognostic marker for multiple types ..
  32. Wolter P, Hanselmann S, Pattschull G, Schruf E, Gaubatz S. Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy. Oncotarget. 2017;8:11160-11172 pubmed publisher
    ..We demonstrate that six mitotic kinesins and two microtubule-associated non-motor proteins (MAPs) CEP55 and PRC1 are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cells...
  33. Liu L, Mei Q, Zhao J, Dai Y, Fu Q. Suppression of CEP55 reduces cell viability and induces apoptosis in human lung cancer. Oncol Rep. 2016;36:1939-1945 pubmed publisher
    Centrosomal protein 55 (CEP55), identified as a centrosome?associated protein, has been reported to be involved in human malignancies. However, its biological function in human lung cancer remains largely unknown...
  34. Shionoya Y, Kanaseki T, Miyamoto S, Tokita S, Hongo A, Kikuchi Y, et al. Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition. Oncoimmunology. 2017;6:e1274476 pubmed publisher
    ..We induced the CTLs recognizing endogenous tumor-associated antigens (TAA), survivin or cep55, and they responded to each tapasin-proficient wild type...
  35. Jeffery J, Sinha D, Srihari S, Kalimutho M, Khanna K. Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis. Oncogene. 2016;35:683-90 pubmed publisher
    b>CEP55 was initially identified as a pivotal component of abscission, the final stage of cytokinesis, serving to regulate the physical separation of two daughter cells...
  36. Suzuki H, Kawasaki M, Inuzuka T, Okumura M, Kakiuchi T, Shibata H, et al. Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism. Structure. 2008;16:1562-73 pubmed publisher
    ..pocket accessible to the critical PPYP motif, which partially overlaps with the GPP motif for the binding of Cep55 (centrosome protein 55 kDa)...
  37. Mondal G, Rowley M, Guidugli L, Wu J, Pankratz V, Couch F. BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis. Dev Cell. 2012;23:137-52 pubmed publisher
    ..of endosomal sorting complex required for transport (ESCRT)-associated proteins, Alix and Tsg101, and formation of CEP55-Alix and CEP55-Tsg101 complexes during abscission...
  38. Morita E, Colf L, Karren M, Sandrin V, Rodesch C, Sundquist W. Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Proc Natl Acad Sci U S A. 2010;107:12889-94 pubmed publisher
    ..ESCRT pathway, ALIX and TSG101, are recruited to the midbody through direct interactions with the phosphoprotein CEP55. CEP55 resides at the centrosome through most of the cell cycle but then migrates to the midbody at the start of ..
  39. Inoda S, Hirohashi Y, Torigoe T, Nakatsugawa M, Kiriyama K, Nakazawa E, et al. Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma. J Immunother. 2009;32:474-85 pubmed publisher
    ..We have found that the centrosomal protein, Cep55/c10orf3 acts as a novel breast carcinoma-associated tumor-associated antigen...
  40. Frosk P, Arts H, Philippe J, Gunn C, Brown E, Chodirker B, et al. A truncating mutation in CEP55 is the likely cause of MARCH, a novel syndrome affecting neuronal mitosis. J Med Genet. 2017;54:490-501 pubmed publisher
    ..We identified a homozygous nonsense mutation in CEP55 segregating with MARCH...
  41. Tao J, Zhi X, Tian Y, Li Z, Zhu Y, Wang W, et al. CEP55 contributes to human gastric carcinoma by regulating cell proliferation. Tumour Biol. 2014;35:4389-99 pubmed publisher
    Centrosomal protein 55 (CEP55) is the latest found member in the centrosomal relative protein family, which participates in cell-cycle regulation...
  42. Tsai C, Chen C, Chang A, Chan J, Chan S. Upregulation of FLJ10540, a PI3K-association protein, in rostral ventrolateral medulla impairs brain stem cardiovascular regulation during mevinphos intoxication. Biochem Pharmacol. 2015;93:34-41 pubmed publisher
  43. Peng T, Zhou W, Guo F, Wu H, Wang C, Wang L, et al. Centrosomal protein 55 activates NF-κB signalling and promotes pancreatic cancer cells aggressiveness. Sci Rep. 2017;7:5925 pubmed publisher
    Centrosomal protein 55 (CEP55) is a microtubule-bundling protein that participants in cell mitosis. It is overexpressed in several solid tumours and promotes the growth and invasion of cancer cells...
  44. Bailey J, Fields A, Cheng K, Lee A, Wagenaar E, Lagrois R, et al. WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission. J Biol Chem. 2015;290:8987-9001 pubmed publisher
    ..Taken together, these data suggest that WDR5 is specifically targeted to the midbody in the absence of chromatin and that it promotes abscission, perhaps by facilitating midbody microtubule disassembly. ..
  45. St Denis N, Gupta G, Lin Z, Gonzalez Badillo B, Pelletier L, Gingras A. Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission. Mol Cell Proteomics. 2015;14:946-60 pubmed publisher
    ..abscission during early mitosis, by interacting with the mitotic kinase polo-like kinase 1, and with centrosomal protein of 55 kDa (CEP55), an important regulator of abscission...
  46. Yuan L, Chen L, Qian K, Qian G, Wu C, Wang X, et al. Co-expression network analysis identified six hub genes in association with progression and prognosis in human clear cell renal cell carcinoma (ccRCC). Genom Data. 2017;14:132-140 pubmed publisher
    ..Six hub genes (CCNB2, CDC20, CEP55, KIF20A, TOP2A and UBE2C) were identified in both co-expression and protein-protein ..
  47. Bastos R, Barr F. Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission. J Cell Biol. 2010;191:751-60 pubmed publisher
    ..During this period, Plk1 phosphorylates the abscission factor Cep55 in trans and prevents its untimely recruitment to the anaphase spindle...
  48. Chen C, Shiu L, Su L, Huang C, Huang S, Huang C, et al. FLJ10540 is associated with tumor progression in nasopharyngeal carcinomas and contributes to nasopharyngeal cell proliferation, and metastasis via osteopontin/CD44 pathway. J Transl Med. 2012;10:93 pubmed publisher
    ..These findings suggest that FLJ10540 may be critical regulator of disease progression in NPC, and the underlying mechanism may involve in the osteopontin/CD44 pathway. ..
  49. Iwamori T, Iwamori N, Ma L, Edson M, Greenbaum M, Matzuk M. TEX14 interacts with CEP55 to block cell abscission. Mol Cell Biol. 2010;30:2280-92 pubmed publisher
    In somatic cells, abscission, the physical separation of daughter cells at the completion of cytokinesis, requires CEP55, ALIX, and TSG101...
  50. Wang Y, Jin T, Dai X, Xu J. Lentivirus-mediated knockdown of CEP55 suppresses cell proliferation of breast cancer cells. Biosci Trends. 2016;10:67-73 pubmed publisher
    Centrosomal protein 55 (CEP55), as a microtubule-bundling protein, plays an important role in cell cycle regulation. CEP55 has been recognized recently in several human cancers...
  51. Basturk O, Berger M, Yamaguchi H, Adsay V, Askan G, Bhanot U, et al. Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma. Mod Pathol. 2017;30:1760-1772 pubmed publisher
    ..In addition, 4/18 (18%) of intraductal tubulopapillary neoplasms had FGFR2 fusions (FGFR2-CEP55, FGFR2-SASS6, DISP1-FGFR2, FGFR2-TXLNA, and FGFR2-VCL) and 1/18 (5.5%) had STRN-ALK fusion...
  52. Singh P, Srivastava A, Rath S, Dalela D, Goel M, Bhatt M. Expression and clinical significance of Centrosomal protein 55 (CEP55) in human urinary bladder transitional cell carcinoma. Immunobiology. 2015;220:103-8 pubmed publisher
    ..In this context, we evaluated Centrosomal protein 55 kDa (CEP55), which is specifically expressed in normal human testis and various malignancies...
  53. Chen C, Chang A, Li S, Tsai H, Shiu L, Su L, et al. Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancer. Mol Cancer. 2015;14:83 pubmed publisher
    ..Together, our findings define a novel mechanism by which Aurora-A promotes cell malignancy, with potential implications for understanding the clinical action of Aurora-A. ..
  54. Kamranvar S, Gupta D, Huang Y, Gupta R, Johansson S. Integrin signaling via FAK-Src controls cytokinetic abscission by decelerating PLK1 degradation and subsequent recruitment of CEP55 at the midbody. Oncotarget. 2016;7:30820-30 pubmed publisher
    ..b>CEP55, a key protein involved in the abscission process, was localized at the midbody in both adherent and non-adherent ..
  55. Zhang W, Niu C, He W, Hou T, Sun X, Xu L, et al. Upregulation of centrosomal protein 55 is associated with unfavorable prognosis and tumor invasion in epithelial ovarian carcinoma. Tumour Biol. 2016;37:6239-54 pubmed publisher
    Centrosomal protein 55 (CEP55) is a cell cycle regulator implicated in development of certain cancers...
  56. Kuo T, Chen C, Baron D, Onder T, Loewer S, Almeida S, et al. Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol. 2011;13:1214-23 pubmed publisher
    ..and involves autophagic degradation mediated by binding of the autophagic receptor NBR1 to the midbody protein CEP55. Differentiating cells and normal dividing cells do not accumulate MB(d)s and possess high autophagic activity...
  57. Guizetti J, Schermelleh L, Mäntler J, Maar S, Poser I, Leonhardt H, et al. Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. Science. 2011;331:1616-20 pubmed publisher
    ..The identification of contractile filament helices at the intercellular bridge has broad implications for the understanding of cell division and of ESCRT-III-mediated fission of large membrane structures. ..
  58. Wang Q, Tang Y, Xu Y, Xu S, Jiang Y, Dong Q, et al. The X-linked deubiquitinase USP9X is an integral component of centrosome. J Biol Chem. 2017;292:12874-12884 pubmed publisher
    ..Interestingly, we showed that USP9X promotes stabilization of centrosome proteins PCM1 and CEP55 through its catalytic activity...
  59. Hadders M, Agromayor M, Obita T, Perisic O, Caballe A, Kloc M, et al. ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes. Proc Natl Acad Sci U S A. 2012;109:17424-9 pubmed publisher
    ..These results suggest a model whereby MITD1 coordinates the activity of ESCRT-III during abscission with earlier events in the final stages of cell division. ..
  60. Waseem A, Ali M, Odell E, Fortune F, Teh M. Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma. Oral Oncol. 2010;46:536-42 pubmed publisher
    ..Furthermore, we also identified a centrosomal protein CEP55 and a DNA helicase/putative stem cell marker HELLS, which are both downstream targets of FOXM1...
  61. Chang Y, Chen Y, Wu C, Wu Y, Yen T, Ouyang P. Characterization of centrosomal proteins Cep55 and pericentrin in intercellular bridges of mouse testes. J Cell Biochem. 2010;109:1274-85 pubmed publisher
    Centrosomal protein 55 (Cep55), located in the centrosome in interphase cells and recruited to the midbody during cytokinesis, is essential for completion of cell abscission...
  62. Chang Y, Wu C, Yen T, Ouyang P. Centrosomal protein 55 (Cep55) stability is negatively regulated by p53 protein through Polo-like kinase 1 (Plk1). J Biol Chem. 2012;287:4376-85 pubmed publisher
    Centrosomal protein 55 (Cep55), which is localized to the centrosome in interphase cells and recruited to the midbody during cytokinesis, is a regulator required for the completion of cell abscission...