CEP350

Summary

Gene Symbol: CEP350
Description: centrosomal protein 350
Alias: CAP350, GM133, centrosome-associated protein 350, centrosomal protein 350kDa
Species: human
Products:     CEP350

Top Publications

  1. Makalowska I, Sood R, Faruque M, Hu P, Robbins C, Eddings E, et al. Identification of six novel genes by experimental validation of GeneMachine predicted genes. Gene. 2002;284:203-13 pubmed
    ..Our studies support the feasibility of identifying novel genes from regions of interest using draft human genome sequence. ..
  2. Hoppeler Lebel A, Celati C, Bellett G, Mogensen M, Klein Hitpass L, Bornens M, et al. Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex. J Cell Sci. 2007;120:3299-308 pubmed
    ..Here we show that the centrosomal large CAP-Gly protein CAP350 is not only present at the centrosome, but is also present as numerous dots in the pericentrosomal area...
  3. Eguether T, Ermolaeva M, Zhao Y, Bonnet M, Jain A, Pasparakis M, et al. The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. Nat Commun. 2014;5:4585 pubmed publisher
    ..Here we show that CYLD localizes at centrosomes and basal bodies via interaction with the centrosomal protein CAP350 and demonstrate that CYLD must be both at the centrosome and catalytically active to promote ciliogenesis ..
  4. Drevensek S, Goussot M, Duroc Y, Christodoulidou A, Steyaert S, Schaefer E, et al. The Arabidopsis TRM1-TON1 interaction reveals a recruitment network common to plant cortical microtubule arrays and eukaryotic centrosomes. Plant Cell. 2012;24:178-91 pubmed publisher
    ..Interestingly, three motifs of TRMs are found in CAP350, a human centrosomal protein interacting with FOP, and the C-terminal M2 motif of CAP350 is responsible for FOP ..
  5. Yan X, Habedanck R, Nigg E. A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. Mol Biol Cell. 2006;17:634-44 pubmed
    ..Here we show that CAP350 and FOP (FGFR1 oncogene partner) form a centrosomal complex required for MT anchoring...
  6. Erzurumluoglu A, Liu M, Jackson V, Barnes D, Datta G, Melbourne C, et al. Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Mol Psychiatry. 2019;: pubmed publisher
    ..up to 622,409 participants) including a rare SNV, rs150493199, in CCDC141 and two low-frequency SNVs in CEP350 and HDGFRP2...
  7. Wang L, Failler M, Fu W, Dynlacht B. A distal centriolar protein network controls organelle maturation and asymmetry. Nat Commun. 2018;9:3938 pubmed publisher
    ..Finally, we show that Talpid3, C2CD3, and OFD1 differentially regulate the assembly of sub-distal appendages, the CEP350/FOP/CEP19 module, centriolar satellites, and actin networks...
  8. Wang S, Li S, Liu Q, Wu K, Zhang J, Wang S, et al. The OsSPL16-GW7 regulatory module determines grain shape and simultaneously improves rice yield and grain quality. Nat Genet. 2015;47:949-54 pubmed publisher
    ..encoding a TONNEAU1-recruiting motif protein with similarity to C-terminal motifs of the human centrosomal protein CAP350. Upregulation of GW7 expression was correlated with the production of more slender grains, as a result of ..
  9. Ho S, Rao R, To S, Schoch E, Tarapore P. Bisphenol A and its analogues disrupt centrosome cycle and microtubule dynamics in prostate cancer. Endocr Relat Cancer. 2017;24:83-96 pubmed publisher
    ..to these analogues, which, for BPA, was accompanied by increased expression of centrosome-associated protein CEP350 Similar to BPA, chronic treatment of cells with DMBPA, but not other analogues, resulted in the enhancement of ..

More Information

Publications18

  1. Cheng C, Zhang H, Li Y, Zhou Y, Lu W, Yao L. The effect of Diosmin on the blood proteome in a rat model of venous thrombosis. Int J Biol Macromol. 2017;104:778-787 pubmed publisher
    ..treatment by two-dimensional gel electrophoresis (2-DE), and investigate the effect of a crucial protein known as CEP350 on human vascular endothelial cell growth...
  2. Mann M, Black M, Jones D, Ward J, Yew C, Newberg J, et al. Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma. Nat Genet. 2015;47:486-95 pubmed publisher
    ..We also functionally validate CEP350 as a new tumor-suppressor gene in human melanoma...
  3. Drabik A, Bodzon Kulakowska A, Suder P, Silberring J, Kulig J, Sierzega M. Glycosylation Changes in Serum Proteins Identify Patients with Pancreatic Cancer. J Proteome Res. 2017;16:1436-1444 pubmed publisher
    ..Here, we report four proteins (LIFR, CE350, VP13A, HPT) found in sera from pancreatic cancer patients carrying aberrant glycan structures as compared to those of controls. ..
  4. Nishijima Y, Hagiya Y, Kubo T, Takei R, Katoh Y, Nakayama K. RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly. Mol Biol Cell. 2017;28:1652-1666 pubmed publisher
    ..These results indicate that RABL2 localized to the basal body plays crucial roles in ciliary/flagellar assembly via its interaction with the IFT-B complex. ..
  5. Weidemann M, Schuster Gossler K, Stauber M, Wrede C, Hegermann J, Ott T, et al. CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Development. 2016;143:4736-4748 pubmed
    ..CFAP157 protein localises to basal bodies and interacts with tubulin and the centrosomal protein CEP350. Cfap157 knockout mice appear normal but homozygous males are infertile...
  6. Mojarad B, Gupta G, Hasegan M, Goudiam O, Basto R, Gingras A, et al. CEP19 cooperates with FOP and CEP350 to drive early steps in the ciliogenesis programme. Open Biol. 2017;7: pubmed publisher
    ..Here, we demonstrate functional interplay between CEP19, FOP and CEP350 in ciliogenesis...
  7. Gavilan M, Arjona M, Zurbano A, Formstecher E, Martínez Morales J, Bornens M, et al. Alpha-catenin-dependent recruitment of the centrosomal protein CAP350 to adherens junctions allows epithelial cells to acquire a columnar shape. PLoS Biol. 2015;13:e1002087 pubmed publisher
    ..Here, we report that the centrosomal microtubule (MT)-binding protein CAP350 localises at adherens junctions in epithelial cells...
  8. Patel H, Truant R, Rachubinski R, Capone J. Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350. J Cell Sci. 2005;118:175-86 pubmed
    ..We show here that PPAR(alpha) interacts with the centrosome-associated protein CAP350. CAP350 also interacts with PPAR(delta), PPAR(gamma) and liver-X-receptor alpha, but not with the 9-cis retinoic ..
  9. Kanie T, Abbott K, Mooney N, Plowey E, Demeter J, JACKSON P. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell. 2017;42:22-36.e12 pubmed publisher
    ..and mass spectrometry of interactors of the centrosomal and ciliopathy protein, CEP19, we identify CEP350, FOP, and the RABL2B GTPase as proteins organizing the first known mechanism directing ciliary entry of IFT ..