CEP152

Summary

Gene Symbol: CEP152
Description: centrosomal protein 152
Alias: MCPH4, MCPH9, SCKL5, centrosomal protein of 152 kDa, asterless, centrosomal protein 152kDa, microcephaly, primary autosomal recessive 4
Species: human
Products:     CEP152

Top Publications

  1. Cizmecioglu O, Arnold M, Bahtz R, Settele F, Ehret L, Haselmann Weiss U, et al. Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. J Cell Biol. 2010;191:731-9 pubmed publisher
    ..In this study, we show that the pericentriolar material protein, Cep152, interacts with the distinctive cryptic Polo-box of Plk4 via its N-terminal domain and is required for Plk4-..
  2. Kim T, Park J, Shukla A, Choi S, Murugan R, Lee J, et al. Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152. Proc Natl Acad Sci U S A. 2013;110:E4849-57 pubmed publisher
    ..localizes to distinct subcentrosomal regions in a temporally and spatially regulated manner, and that Cep192 and Cep152 serve as two distinct scaffolds that recruit Plk4 to centrosomes in a hierarchical order...
  3. Dzhindzhev N, Yu Q, Weiskopf K, Tzolovsky G, Cunha Ferreira I, Riparbelli M, et al. Asterless is a scaffold for the onset of centriole assembly. Nature. 2010;467:714-8 pubmed publisher
    ..Here we show that the centriolar protein Asterless (Asl; human orthologue CEP152) provides a conserved molecular platform, the amino terminus of which interacts ..
  4. Lukinavicius G, Lavogina D, Orpinell M, Umezawa K, Reymond L, Garin N, et al. Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex. Curr Biol. 2013;23:265-70 pubmed publisher
    ..We reveal that Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles...
  5. Guernsey D, Jiang H, Hussin J, Arnold M, Bouyakdan K, Perry S, et al. Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4. Am J Hum Genet. 2010;87:40-51 pubmed publisher
    ..CEP152 is the putative mammalian ortholog of Drosphila asterless, mutations in which affect mitosis in the fly...
  6. Tang C, Lin S, Hsu W, Lin Y, Wu C, Lin Y, et al. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. EMBO J. 2011;30:4790-804 pubmed publisher
    ..Together, our results indicate that the two MCPH-associated proteins STIL and CPAP interact with each other and are required for procentriole formation, implying a central role of centriole biogenesis in MCPH...
  7. Hatch E, Kulukian A, Holland A, Cleveland D, Stearns T. Cep152 interacts with Plk4 and is required for centriole duplication. J Cell Biol. 2010;191:721-9 pubmed publisher
    ..and frog cells that Plk4 interacts with the centrosome protein Cep152, the orthologue of Drosophila melanogaster Asterless. The interaction requires the N-terminal 217 residues of Cep152 and the crypto Polo-box of Plk4...
  8. Sonnen K, Gabryjonczyk A, Anselm E, Stierhof Y, Nigg E. Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication. J Cell Sci. 2013;126:3223-33 pubmed publisher
    ..In flies, Plk4 recruitment depends on Asterless, whereas nematodes rely on a distinct protein, Spd-2...
  9. Kim T, Zhang L, Il Ahn J, Meng L, Chen Y, Lee E, et al. Molecular architecture of a cylindrical self-assembly at human centrosomes. Nat Commun. 2019;10:1151 pubmed publisher
    ..Here we show that two human pericentriolar material scaffolds, Cep63 and Cep152, cooperatively generate a heterotetrameric α-helical bundle that functions in conjunction with its neighboring ..

More Information

Publications33

  1. Coelho P, Bury L, Sharif B, Riparbelli M, Fu J, Callaini G, et al. Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles. Dev Cell. 2013;27:586-97 pubmed publisher
    ..We show that Plk4 function depends on its kinase activity and its partner protein, Cep152. Moreover, tethering Cep152 to cellular membranes sequesters Plk4 and is sufficient to trigger spindle assembly ..
  2. Varadarajan R, Rusan N. Bridging centrioles and PCM in proper space and time. Essays Biochem. 2018;62:793-801 pubmed publisher
    ..Here, we review Sas-4/CPAP, Asterless/Cep152, Spd-2/Cep192, and PLP/Pericentrin, a group of proteins we refer to as 'bridge' proteins that reside at ..
  3. Saurya S, Roque H, Novak Z, Wainman A, Aydogan M, Volanakis A, et al. Drosophila Ana1 is required for centrosome assembly and centriole elongation. J Cell Sci. 2016;129:2514-25 pubmed publisher
    ..known as Bld10) initially recruits Ana1 to newly formed centrioles, and that Ana1 then recruits Asl (known as Cep152 in mammals) to promote the conversion of these centrioles into centrosomes...
  4. Galletta B, Jacobs K, Fagerstrom C, Rusan N. Asterless is required for centriole length control and sperm development. J Cell Biol. 2016;213:435-50 pubmed publisher
    ..Loss of the centriole protein Asterless (Asl), the Drosophila melanogaster orthologue of Cep152, prevents centriole duplication, which has limited the ..
  5. Fu J, Lipinszki Z, Rangone H, Min M, Mykura C, Chao Chu J, et al. Conserved molecular interactions in centriole-to-centrosome conversion. Nat Cell Biol. 2016;18:87-99 pubmed publisher
    ..Here we show that centriole-to-centrosome conversion requires sequential loading of Cep135, Ana1 (Cep295) and Asterless (Cep152) onto daughter centrioles during mitotic progression in both Drosophila melanogaster and human...
  6. Yigit G, Brown K, Kayserili H, Pohl E, Caliebe A, Zahnleiter D, et al. Mutations in CDK5RAP2 cause Seckel syndrome. Mol Genet Genomic Med. 2015;3:467-80 pubmed publisher
    ..A severely affected child of nonconsanguineous German parents was found to carry heterozygous mutations in CDK5RAP2 and CEP152. This finding points toward a potential additive genetic effect of mutations in CDK5RAP2 and CEP152.
  7. Xu Q, Zhang Y, Xiong X, Huang Y, Salisbury J, Hu J, et al. PIPKI? targets to the centrosome and restrains centriole duplication. J Cell Sci. 2014;127:1293-305 pubmed publisher
    ..This localization was dependent upon an association with centrosomal protein of 152 KDa (CEP152)...
  8. Sir J, Barr A, Nicholas A, Carvalho O, Khurshid M, Sossick A, et al. A primary microcephaly protein complex forms a ring around parental centrioles. Nat Genet. 2011;43:1147-53 pubmed publisher
    ..CEP63 forms a complex with another MCPH protein, CEP152, a conserved centrosome duplication factor...
  9. Fung E, Richter C, Yang H, Schäffer I, Fischer R, Kessler B, et al. FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration. EMBO Rep. 2018;19: pubmed publisher
    ..E3 ubiquitin ligases, is enriched at centrosomes and interacts with the centrosomal proteins Centrin-2, Centrin-3, CEP152 and CEP192. Among these, CEP192 is specifically targeted for proteasomal degradation by FBXL13...
  10. Khan M, Windpassinger C, Ali M, Zubair M, Gul H, Abbas S, et al. Molecular genetic analysis of consanguineous families with primary microcephaly identified pathogenic variants in the ASPM gene. J Genet. 2017;96:383-387 pubmed
    ..have identified 15 (MCPH) causative genes that include MCPH1, WDR62, CDK5RAP2, CASC5, ASPM, CENPJ, STIL, CEP135, CEP152, ZNF335, PHC1, CDK6, CENPE, SASS6 MFSD2A ANKLE2 and CIT (Khan et al. 2014; Yamamoto et al. 2014; Alakbarzade et al...
  11. Faheem M, Naseer M, Rasool M, Chaudhary A, Kumosani T, Ilyas A, et al. Molecular genetics of human primary microcephaly: an overview. BMC Med Genomics. 2015;8 Suppl 1:S4 pubmed publisher
    ..the world and contain the following genes: Microcephalin, WDR62, CDK5RAP2, CASC5, ASPM, CENPJ, STIL, CEP135, CEP152, ZNF335, PHC1 and CDK6...
  12. Brown N, Marjanović M, Lüders J, Stracker T, Costanzo V. Cep63 and cep152 cooperate to ensure centriole duplication. PLoS ONE. 2013;8:e69986 pubmed publisher
    ..centrosome or spindle pole proteins that cause autosomal recessive primary microcephaly, including Cep63 and Cep152. In this study we show that Cep63 functions to ensure that centriole duplication occurs reliably in dividing ..
  13. Jamieson C, Govaerts C, Abramowicz M. Primary autosomal recessive microcephaly: homozygosity mapping of MCPH4 to chromosome 15. Am J Hum Genet. 1999;65:1465-9 pubmed
  14. Yuasa I, Umetsu K, Matsusue A, Nishimukai H, Harihara S, Fukumori Y, et al. A Japanese-specific allele in the GALNT11 gene. Leg Med (Tokyo). 2010;12:208-11 pubmed publisher
    In this study, five single nucleotide polymorphisms (SNPs) in the ABCC4, FBN1, CEP152, ZNF804B, and GALNT11 genes were investigated to assess allele frequencies in 14 different populations by a novel pentaplex PCR method...
  15. Park S, Park J, Kim T, Kim J, Kwak M, Ku B, et al. Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis. Nat Struct Mol Biol. 2014;21:696-703 pubmed publisher
    ..We show that Plk4 relocalizes from the inner Cep192 ring to the outer Cep152 ring as newly recruited Cep152 assembles around the Cep192-encircled daughter centriole...
  16. Lukinavicius G, Lavogina D, GONCZY P, Johnsson K. Commercial Cdk1 antibodies recognize the centrosomal protein Cep152. Biotechniques. 2013;55:111-4 pubmed
  17. Byrne E, Gehrman P, Medland S, Nyholt D, Heath A, Madden P, et al. A genome-wide association study of sleep habits and insomnia. Am J Med Genet B Neuropsychiatr Genet. 2013;162B:439-51 pubmed publisher
    ..We did not replicate the results from previous genome-wide analyses of self-reported sleep phenotypes after correction for multiple testing. ..
  18. Gubin A, Njoroge J, Bouffard G, Miller J. Gene expression in proliferating human erythroid cells. Genomics. 1999;59:168-77 pubmed
    ..In addition to known transcripts, 44 novel EST were discovered. This transcriptional profile provides the first genomic-scale description of gene activity in erythroid progenitor cells. ..
  19. Van de Mark D, Kong D, Loncarek J, Stearns T. MDM1 is a microtubule-binding protein that negatively regulates centriole duplication. Mol Biol Cell. 2015;26:3788-802 pubmed publisher
    ..We propose that MDM1 is a negative regulator of centriole duplication and that its function is mediated through microtubule binding. ..
  20. Kalay E, Yigit G, Aslan Y, Brown K, Pohl E, Bicknell L, et al. CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Nat Genet. 2011;43:23-6 pubmed publisher
    ..Here we describe the centrosomal protein CEP152 as a new regulator of genomic integrity and cellular response to DNA damage...
  21. Kodani A, Yu T, Johnson J, Jayaraman D, Johnson T, Al Gazali L, et al. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. elife. 2015;4: pubmed publisher
    Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome...
  22. Xu S, Sun X, Niu X, Zhang Z, Tian R, Ren W, et al. Genetic basis of brain size evolution in cetaceans: insights from adaptive evolution of seven primary microcephaly (MCPH) genes. BMC Evol Biol. 2017;17:206 pubmed publisher
    ..Extensive positive selection was identified in four of six intact MCPH genes: WDR62, CDK5RAP2, CEP152, and ASPM...
  23. Lee I, Jo Y, Jung S, Wang H, Kim N, Namgoong S. Distinct roles of Cep192 and Cep152 in acentriolar MTOCs and spindle formation during mouse oocyte maturation. FASEB J. 2017;: pubmed publisher
    ..We showed that two pericentriolar proteins, Cep192 and Cep152, play crucial roles during MTOC remodeling in mouse oocytes...