CELA2A

Summary

Gene Symbol: CELA2A
Description: chymotrypsin like elastase family member 2A
Alias: ELA2A, PE-1, chymotrypsin-like elastase family member 2A, elastase 2A, pancreatic elastase 2, pancreatic elastase IIA
Species: human
Products:     CELA2A

Top Publications

  1. Sánchez Arévalo Lobo V, Fernández L, Carrillo de Santa Pau E, Richart L, Cobo I, Cendrowski J, et al. c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis. Gut. 2018;67:707-718 pubmed publisher
    ..c-Myc repression during development is crucial for the maturation of preacinar cells, and c-Myc overexpression can contribute to pancreatic carcinogenesis through the induction of a dedifferentiated state. ..
  2. Seleznik G, Reding T, Romrig F, Saito Y, Mildner A, Segerer S, et al. Lymphotoxin ? receptor signaling promotes development of autoimmune pancreatitis. Gastroenterology. 2012;143:1361-1374 pubmed publisher
    ..Overexpression of LT?? specifically in acinar cells of mice causes features of AIP. Reagents that neutralize LT?R ligands might be used to treat patients with AIP. ..
  3. Walkowiak J, Glapa A, Nowak J, Bober L, Rohovyk N, Wenska Chyży E, et al. Pancreatic Elastase-1 Quick Test for rapid assessment of pancreatic status in cystic fibrosis patients. J Cyst Fibros. 2016;15:664-8 pubmed publisher
    ..8 and 90.5% in CF patients. Pancreatic Elastase-1 Quick Test™ proves to be a rapid and reliable option to qualitatively evaluate pancreatic function for diagnostic purposes in a clinical setting of CF care. ..
  4. Gruber R, Panayiotou R, Nye E, Spencer Dene B, Stamp G, Behrens A. YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling. Gastroenterology. 2016;151:526-39 pubmed publisher
    ..This process involves activation of YAP1 and TAZ in acinar cells, which up-regulate JAK-STAT3 signaling to promote development of PDAC in mice. ..
  5. Wilson M, Harreman M, Taschner M, Reid J, Walker J, Erdjument Bromage H, et al. Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress. Cell. 2013;154:983-995 pubmed publisher
    ..Together, these results outline the multistep mechanism of Rpb1 polyubiquitylation triggered by transcription stress and uncover the key role played by Def1 as a facilitator of Elongin-Cullin ubiquitin ligase function. ..
  6. Masuda M, Li Y, Pak K, Chavez E, Mullen L, Ryan A. The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells. Mol Neurobiol. 2017;54:5414-5426 pubmed publisher
    ..4 kb of upstream sequence determines expression level. These data will assist in the identification of mutations in noncoding, regulatory regions of this deafness gene. ..
  7. Borbély Y, Plebani A, Kröll D, Ghisla S, Nett P. Exocrine Pancreatic Insufficiency after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2016;12:790-794 pubmed publisher
    ..Prevalence of EPI after dRYGB (48%) and pRYGB (19%) is of clinical importance. There was no significant difference in absolute or relative limb lengths between EPI and non-EPI groups after dRYGB. ..
  8. Winter C, Yamaguchi N, Wu M, Wagner D. Transcriptional programs regulated by both LEAFY and APETALA1 at the time of flower formation. Physiol Plant. 2015;155:55-73 pubmed publisher
    ..Our study contributes to the elucidation of the regulatory network that leads to formation of a vital plant organ system, the flower. ..
  9. Bana N, Nyiri A, Nagy J, Frank K, Nagy T, Stéger V, et al. The red deer Cervus elaphus genome CerEla1.0: sequencing, annotating, genes, and chromosomes. Mol Genet Genomics. 2018;293:665-684 pubmed publisher
    ..Genome-wide association studies (GWAS) that CerEla1.0 (NCBI, MKHE00000000) could serve for are discussed. ..

More Information

Publications22

  1. Tóth A, Szabo A, Hegyi E, Hegyi P, Sahin Toth M. Detection of human elastase isoforms by the ScheBo Pancreatic Elastase 1 Test. Am J Physiol Gastrointest Liver Physiol. 2017;312:G606-G614 pubmed publisher
    ..found that the test specifically measured chymotrypsin-like elastases (CELA) 3A and 3B (CELA3A and CELA3B), while CELA2A was not detected...
  2. Lausen J, Liu S, Fliegauf M, Lubbert M, Werner M. ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO. Oncogene. 2006;25:1349-57 pubmed
    ..These protein-protein interactions may not require simultaneous DNA binding by AML1-ETO for the deleterious effects of the fusion protein to be realized. ..
  3. Kerns S, Ostrer H, Stock R, Li W, Moore J, Pearlman A, et al. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2010;78:1292-300 pubmed publisher
    ..This study demonstrates the feasibility of a genome-wide approach to investigate genetic predisposition to radiation injury. ..
  4. Szepessy E, Sahin Toth M. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. Pancreatology. 2006;6:117-22 pubmed
    ..Recombinant ELA2A and ELA2B were expressed in Escherichia coli, and their activity was tested on Glt-Ala-Ala-Pro-Leu-p-nitroanilide, ..
  5. Friess H, Ding J, Kleeff J, Liao Q, Berberat P, Hammer J, et al. Identification of disease-specific genes in chronic pancreatitis using DNA array technology. Ann Surg. 2001;234:769-78; discussion 778-9 pubmed
    ..These results may provide new insight into the pathobiology of CP and help identify certain molecular alterations that might serve as targets for new diagnostic tools and disease-specific therapy. ..
  6. Szabo A, Pilsak C, Bence M, Witt H, Sahin Toth M. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. J Biol Chem. 2016;291:17706-16 pubmed publisher
    ..protease zymogens in a systematic manner, we performed binding experiments using recombinant proelastases CELA2A, CELA3A, and CELA3B; chymotrypsinogens CTRB1, CTRB2, CTRC, and CTRL1; and procarboxypeptidases CPA1, CPA2, and ..
  7. Damodaren N, Van Eeuwen T, Zamel J, Lin Shiao E, Kalisman N, Murakami K. Def1 interacts with TFIIH and modulates RNA polymerase II transcription. Proc Natl Acad Sci U S A. 2017;114:13230-13235 pubmed publisher
    ..Taken together, our results extend the understanding of the molecular mechanism of transcription regulation on cellular stress and reveal functional similarities to the mammalian system. ..
  8. Kawashima I, Tani T, Shimoda K, Takiguchi Y. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. DNA. 1987;6:163-72 pubmed
    ..Blot hybridization analysis of the poly-adenylated RNAs isolated from various human tissues demonstrates that the human elastase II mRNAs are specifically detected in the pancreas. ..
  9. Fletcher T, Shen W, Largman C. Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. Biochemistry. 1987;26:7256-61 pubmed
    ..These studies indicate that elastases 2 and elastase 1 both contain an Arg-65A as well as a basic dipeptide at 223/224 which is not present in chymotrypsins.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  10. Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, et al. Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. J Biochem. 1987;102:1555-63 pubmed
    We have cloned a DNA that is complementary to the messenger RNA that encodes human pancreatic elastase 2 from a human pancreatic cDNA library using a cloned cDNA for rat pancreatic elastase 2 messenger RNA...
  11. Dooley J, Pasciuto E, Lagou V, Lampi Y, Dresselaers T, Himmelreich U, et al. NOD mice, susceptible to pancreatic autoimmunity, demonstrate delayed growth of pancreatic cancer. Oncotarget. 2017;8:80167-80174 pubmed publisher
  12. Moulard M, Michon T, Kerfelec B, Chapus C. Further studies on the human pancreatic binary complexes involving procarboxypeptidase A. FEBS Lett. 1990;261:179-83 pubmed
    ..Only one type of procarboxypeptidase B, the B1 type, has been detected in the analyzed pancreatic juices, thus emphasizing the previously observed genetic differences between individuals. ..
  13. Bonnart C, Deraison C, Lacroix M, Uchida Y, Besson C, Robin A, et al. Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. J Clin Invest. 2010;120:871-82 pubmed publisher
    ..These results highlight the importance of the control of epidermal protease activity in skin homeostasis and designate ELA2 as a major protease driving the pathogenesis of NS. ..