Gene Symbol: CEBPD
Description: CCAAT enhancer binding protein delta
Alias: C/EBP-delta, CELF, CRP3, NF-IL6-beta, CCAAT/enhancer-binding protein delta, CCAAT/enhancer binding protein (C/EBP), delta, c/EBP delta, nuclear factor NF-IL6-beta
Species: human
Products:     CEBPD

Top Publications

  1. Kinoshita S, Akira S, Kishimoto T. A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci U S A. 1992;89:1473-6 pubmed
    ..These data suggest that NF-IL6 beta is an important transcriptional activator in addition to NF-IL6 in regulation of the genes involved in the immune and inflammatory responses. ..
  2. Chang L, Huang H, Wu P, Jou I, Pan M, Chang W, et al. Role of macrophage CCAAT/enhancer binding protein delta in the pathogenesis of rheumatoid arthritis in collagen-induced arthritic mice. PLoS ONE. 2012;7:e45378 pubmed publisher
    The up-regulation of CCAAT/enhancer binding protein delta (CEBPD) has frequently been observed in macrophages in age-associated disorders, including rheumatoid arthritis (RA)...
  3. Sarkar T, Sharan S, Wang J, Pawar S, Cantwell C, Johnson P, et al. Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells. Mol Cell Biol. 2012;32:320-32 pubmed publisher
    The transcription factor CCAAT/enhancer-binding protein delta (C/EBPδ, CEBPD) is a tumor suppressor that is downregulated during breast cancer progression but may also promote metastasis...
  4. Zhu Y, Saunders M, Yeh H, Deng W, Wu K. Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins. J Biol Chem. 2002;277:6923-8 pubmed
    ..These findings provide new insight into the regulation of cyclooxygenase-2 promoter by an interplay between two opposite beta isoforms and p300 co-activator. ..
  5. Angeloni D, Lee J, Johnson B, Teh B, Dean M, Lerman M, et al. C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2. Mol Cell Probes. 2001;15:395-7 pubmed
  6. Gery S, Tanosaki S, Hofmann W, Koppel A, Koeffler H. C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation. Oncogene. 2005;24:1589-97 pubmed
  7. Borrelli S, Testoni B, Callari M, Alotto D, Castagnoli C, Romano R, et al. Reciprocal regulation of p63 by C/EBP delta in human keratinocytes. BMC Mol Biol. 2007;8:85 pubmed
    ..Our data highlight a coherent cross-talk between these two transcription factors in keratinocytes and a large sharing of common transcriptional targets. ..
  8. Lai P, Wang W, Ko C, Lee Y, Yang W, Shen T, et al. HDAC1/HDAC3 modulates PPARG2 transcription through the sumoylated CEBPD in hepatic lipogenesis. Biochim Biophys Acta. 2008;1783:1803-14 pubmed publisher
    ..Overexpression of CEBPdelta (CEBPD) enhances lipid accumulation and specifically activates PPARG2 transcription in HepG2 cells...
  9. Ali S, Singh N, Yildirim H, Ramji D. Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes. Int J Biochem Cell Biol. 2010;42:113-9 pubmed publisher
    ..Taken together, these results suggest a potentially crucial role for NF-kappaB in the IL-1-induced expression of C/EBPdelta, and thereby downstream APP genes regulated by this transcription factor. ..

More Information


  1. Wang J, Ko C, Chen L, Wang W, Chang W. Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene. Nucleic Acids Res. 2006;34:217-31 pubmed
    ..These results indicated that NF-IL6beta plays a pivotal role in the regulation of basal and EGF-induced cox-2 transcription. ..
  2. Nagulapalli S, Pongubala J, Atchison M. Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3). J Immunol. 1995;155:4330-8 pubmed
    ..These results suggest that transcriptional synergy is due to each protein independently influencing the basal transcription complex. ..
  3. Dong J, Fujii S, Imagawa S, Matsumoto S, Matsushita M, Todo S, et al. IL-1 and IL-6 induce hepatocyte plasminogen activator inhibitor-1 expression through independent signaling pathways converging on C/EBPdelta. Am J Physiol Cell Physiol. 2007;292:C209-15 pubmed
    ..Thus IL-1 and IL-6 exert directionally similar effects on PAI-1 expression, but the induction involves distinct signaling pathways with a final common mediator, C/EBPdelta. ..
  4. Agrawal S, Hofmann W, Tidow N, Ehrich M, van den Boom D, Koschmieder S, et al. The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia. Blood. 2007;109:3895-905 pubmed
    ..C/EBPdelta exhibited growth-inhibitory properties in primary progenitor cells as well as in Flt3-ITD-transformed cells. Taken together, C/EBPdelta is a novel tumor suppressor gene in AML that is silenced by promoter methylation. ..
  5. Barresi V, Vitarelli E, Cerasoli S, Barresi G. The cell growth inhibitory transcription factor C/EBPdelta is expressed in human meningiomas in association with low histological grade and proliferation index. J Neurooncol. 2010;97:233-40 pubmed publisher
    ..If further studies confirm its induction by inflammatory mediators, this might be exploited in novel therapies to prevent recurrences in meningiomas. ..
  6. Hour T, Lai Y, Kuan C, Chou C, Wang J, Tu H, et al. Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells. Biochem Pharmacol. 2010;80:325-34 pubmed publisher
    ..Here, we report that expression of the CCAAT/enhancer binding protein delta (CEBPD, C/EBPdelta, NF-IL6beta) is induced by cisplatin in the human bladder urothelial carcinoma NTUB1 cell line and is ..
  7. Pan Y, Li C, Ko C, Pan M, Chen P, Tseng J, et al. CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells. Clin Cancer Res. 2010;16:5770-80 pubmed publisher
    Recent evidence indicates that a tumor suppressor gene CEBPD (CCAAT/enhancer-binding protein delta) is downregulated in many cancers including cervical cancer, which provides a therapeutic potential associated with its reactivation...
  8. Balamurugan K, Wang J, Tsai H, Sharan S, Anver M, Leighty R, et al. The tumour suppressor C/EBP? inhibits FBXW7 expression and promotes mammary tumour metastasis. EMBO J. 2010;29:4106-17 pubmed publisher
    ..The CCAAT/enhancer-binding protein-? (C/EBP?, CEBPD) is an inflammatory response gene and candidate tumour suppressor, but its physiological role in tumourigenesis in ..
  9. Tong Y, Zhou J, Mizutani J, Fukuoka H, Ren S, Gutierrez Hartmann A, et al. CEBPD suppresses prolactin expression and prolactinoma cell proliferation. Mol Endocrinol. 2011;25:1880-91 pubmed publisher
    ..Using microarray-based gene expression profiling, we identified CCAAT-enhancer-binding protein ? (CEBPD) transcription factor as a critical gene that regulates both PRL expression and lactotroph cell proliferation...
  10. Moore F, Santin I, Nogueira T, Gurzov E, Marselli L, Marchetti P, et al. The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells. PLoS ONE. 2012;7:e31062 pubmed publisher
    ..These observations identify a novel function of C/EBP? as a modulatory transcription factor that inhibits the pro-apoptotic and pro-inflammatory gene networks activated by cytokines in pancreatic ?-cells. ..
  11. Hsiao Y, Li C, Chi J, Tseng J, Chang Y, Hsu L, et al. CCAAT/enhancer binding protein δ in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma. Sci Signal. 2013;6:ra59 pubmed publisher
    ..the nucleocytoplasmic shuttling of the RNA binding protein Hu antigen R (HuR), which bound to and stabilized CEBPD mRNA in macrophages...
  12. Tang D, Sivko G, DeWille J. Promoter methylation reduces C/EBPdelta (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors. Breast Cancer Res Treat. 2006;95:161-70 pubmed
    ..These results demonstrate a direct link between C/EBPdelta gene promoter hyper- and site specific-methylation and reduced C/EBPdelta gene expression in breast cancer cell lines and primary breast tumors. ..
  13. Chen P, Riley D, Chen Y, Lee W. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 1996;10:2794-804 pubmed
    ..Such a role contrasts with the function of Rb in arresting cell cycle progression in G1 by negative regulation of other transcription factors like E2F-1. ..
  14. Dearth L, DeWille J. Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells. J Biol Chem. 2003;278:11246-55 pubmed
  15. Milde Langosch K, Löning T, Bamberger A. Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins. Breast Cancer Res Treat. 2003;79:175-85 pubmed
    ..These results suggest that high C/EBPbeta expression might be involved in tumor progression and indicative of an unfavorable prognosis. ..
  16. Kovács K, Steinmann M, Magistretti P, Halfon O, Cardinaux J. CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation. J Biol Chem. 2003;278:36959-65 pubmed
  17. Li R, Strohmeyer R, Liang Z, Lue L, Rogers J. CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease. Neurobiol Aging. 2004;25:991-9 pubmed
  18. Wang J, Tseng J, Chang W. Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells. Mol Biol Cell. 2005;16:3365-76 pubmed
    The CCAAT/enhancer binding protein delta (C/EBPdelta, CRP3, CELF, NF-IL6beta) regulates gene expression and plays functional roles in many tissues, such as in acute phase response to inflammatory stimuli, adipocyte differentiation, and ..
  19. Brueckner L, Hess E, Schwab M, Savelyeva L. Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer. Cancer Lett. 2013;336:85-95 pubmed publisher
    ..FRA8I encompasses KIAA0146, a large protein-coding gene with yet unknown function, as well as CEBPD and part of PRKDC, two genes encoding proteins involved in tumorigenesis in a variety of cancers...
  20. Choy L, Derynck R. Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J Biol Chem. 2003;278:9609-19 pubmed
    ..Smad3/4 did not reduce the ability of C/EBP to bind to its cognate DNA sequence, but repressed transcription by inhibiting the transactivation function of C/EBP. ..
  21. Min Y, Ghose S, Boelte K, Li J, Yang L, Lin P. C/EBP-? regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung cancer through HIF-1?. Oncogene. 2011;30:4901-9 pubmed publisher
    ..Blocking HIF-1? activity totally blocked CEBP-?-induced VEGF-C and VEGFR3 expression in LECs. Together, these findings uncover a new function of CEBP-? in lymphangiogenesis through regulation of VEGFR3 signaling in LECs. ..
  22. Ko C, Chang L, Lee Y, Sterneck E, Cheng C, Chen S, et al. CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells. Neurobiol Aging. 2012;33:422.e11-25 pubmed publisher
    The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ, NF-IL6β) is induced in many inflammation-related diseases, suggesting that CEBPD and its downstream targets may play central roles in these conditions...
  23. Borrelli S, Fanoni D, Dolfini D, Alotto D, Ravo M, Grober O, et al. C/EBPδ gene targets in human keratinocytes. PLoS ONE. 2010;5:e13789 pubmed publisher
    ..Our data indicate that C/EBPδ plays a role in late stages of keratinocyte differentiation. ..
  24. Zannetti C, Bonnay F, Takeshita F, Parroche P, Menetrier Caux C, Tommasino M, et al. C/EBP{delta} and STAT-1 are required for TLR8 transcriptional activity. J Biol Chem. 2010;285:34773-80 pubmed publisher
    ..These results shed new light on the mechanisms involved during TLR8-mediated innate immune response. ..
  25. Wang J, Sarkar T, Zhou M, Sharan S, Ritt D, Veenstra T, et al. CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage. Proc Natl Acad Sci U S A. 2010;107:16131-6 pubmed publisher
    ..reported that the transcription factor and tumor suppressor CCAAT/enhancer binding protein δ (C/EBPδ, CEBPD; also known as "NFIL-6β") promotes genomic stability. However, the molecular mechanism was not known...
  26. Bennett C, Nsengimana J, Bostock J, Cymbalista C, Futers T, Knight B, et al. CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. Diab Vasc Dis Res. 2010;7:195-203 pubmed publisher
    ..the genes encoding the transcription factors CCAAT/enhancer binding protein alpha, beta and delta ( CEBPA, CEBPB, CEBPD) and investigate associations between polymorphisms and obesity-related phenotypes...
  27. Barbaro V, Testa A, Di Iorio E, Mavilio F, Pellegrini G, De Luca M. C/EBPdelta regulates cell cycle and self-renewal of human limbal stem cells. J Cell Biol. 2007;177:1037-49 pubmed
    ..Coexpression of CCAAT enhancer binding protein delta (C/EBPdelta), Bmi1, and DeltaNp63alpha identifies mitotically quiescent limbal stem cells, which ..
  28. Dong J, Fujii S, Li H, Nakabayashi H, Sakai M, Nishi S, et al. Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta. Arterioscler Thromb Vasc Biol. 2005;25:1078-84 pubmed
    ..Vascular protection by statins may be partly mediated through regulation of CEBPdelta and consequent modulation of PAI-1 expression. ..
  29. Sanford D, DeWille J. C/EBPdelta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells. Prostate. 2005;63:143-54 pubmed
    ..Ongoing studies are investigating the mechanism by which C/EBPdelta controls prostate cancer cell growth and the potential role of C/EBPdelta in the survival and chemo resistance of prostate cancer metastasis. (c) 2004 Wiley-Liss, Inc. ..
  30. Sivko G, DeWille J. CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: I. "Loss of function" alterations in the c/EBPdelta growth inhibitory pathway in breast cancer cell lines. J Cell Biochem. 2004;93:830-43 pubmed
    ..cytokines (Interleukin-6 and Oncostatin M (OSM))--increase STAT3 phosphorylation (pSTAT3), increase CCAAT enhancer binding protein delta (C/EBPdelta) gene expression and induce GA of primary, finite-lifespan human mammary epithelial ..
  31. Turgeon N, Valiquette C, Blais M, Routhier S, Seidman E, Asselin C. Regulation of C/EBPdelta-dependent transactivation by histone deacetylases in intestinal epithelial cells. J Cell Biochem. 2008;103:1573-83 pubmed
    ..Our results suggest that interactions between C/EBPs and HDAC1 negatively regulate C/EBPdelta-dependent haptoglobin expression in intestinal epithelial cells. ..
  32. Zhou S, Si J, Liu T, DeWille J. PIASy represses CCAAT/enhancer-binding protein delta (C/EBPdelta) transcriptional activity by sequestering C/EBPdelta to the nuclear periphery. J Biol Chem. 2008;283:20137-48 pubmed publisher
    ..PIASy alters C/EBPdelta nuclear localization, reduces C/EBPdelta transcriptional activity, and enhances cell proliferation/migration. ..
  33. Ko C, Hsu H, Shen M, Chang W, Wang J. Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. J Biol Chem. 2008;283:30919-32 pubmed publisher
    Human CCAAT/enhancer-binding protein delta (CEBPD) has been reported as a tumor suppressor because it both induces growth arrest involved in differentiation and plays a crucial role as a regulator of pro-apoptotic gene expression...
  34. Rustenhoven J, Scotter E, Jansson D, Kho D, Oldfield R, Bergin P, et al. An anti-inflammatory role for C/EBPδ in human brain pericytes. Sci Rep. 2015;5:12132 pubmed publisher
    ..The induction of C/EBPδ following immune stimulation may act to limit infiltration of peripheral immune cells, thereby preventing further inflammatory responses in the brain. ..
  35. Wang S, Hsu J, Ko C, Chiu N, Kan W, Lai M, et al. Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury. Mol Neurobiol. 2016;53:5912-5927 pubmed publisher
    ..Although the involvement of other non-astroglial C/EBP? cannot be entirely excluded, our studies suggest that astrocytic C/EBP? is integral to the inflammatory cascades leading to glial scar formation after spinal cord injury. ..
  36. Li M, Zhou W, Yuan R, Chen L, Liu T, Huang D, et al. ROCK2 promotes HCC proliferation by CEBPD inhibition through phospho-GSK3β/β-catenin signaling. FEBS Lett. 2015;589:1018-25 pubmed publisher
    ..CCAAT/enhancer-binding protein delta (CEBPD) functions as a tumor suppressor...
  37. Banerjee S, Aykin Burns N, Krager K, Shah S, Melnyk S, Hauer Jensen M, et al. Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2016;99:296-307 pubmed publisher
    ..The transcription factor CCAAT enhancer binding protein delta (Cebpd, C/EBPδ) has been implicated in the regulation of oxidative stress, DNA damage response, ..
  38. Xia C, Cheshire J, Patel H, Woo P. Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes. Int J Biochem Cell Biol. 1997;29:1525-39 pubmed
    ..These results suggest the NF-kappa B and C/EBP may form a new complex of transcription factors that mediates the synergistic induction of SAA2 by IL-1 and IL-6. ..
  39. Chen M, Himmel M, Wilson D, Brady J. Simulation studies of substrate recognition by the exocellulase CelF from Clostridium cellulolyticum. Biotechnol Bioeng. 2016;113:1433-40 pubmed publisher
    Molecular dynamics (MD) simulations were used to study substrate recognition by the family 48 exocellulase CelF from Clostridium cellulolyticum...
  40. Wang Y, Wu W, Wang W, Huang H, Li W, Yeh B, et al. CEBPD amplification and overexpression in urothelial carcinoma: a driver of tumor metastasis indicating adverse prognosis. Oncotarget. 2015;6:31069-84 pubmed publisher
    ..With this, we identified CEBPD mRNA expression as most significantly associated with gains of 8q11.21, suggesting amplification-driven expression...
  41. Snow P, Woodward M, Mathis M, Powell M. Language functioning, mental health and alexithymia in incarcerated young offenders. Int J Speech Lang Pathol. 2016;18:20-31 pubmed publisher
    ..Only a quarter of the sample overall achieved Clinical Evaluation of Language Fundamentals (CELF-4) Core Language Scores in the expected range; rates of language impairment were higher in indigenous males than in ..
  42. Wang W, Li C, Chu Y, Wang Y, Hour T, Yen C, et al. Inhibition of the EGFR/STAT3/CEBPD Axis Reverses Cisplatin Cross-resistance with Paclitaxel in the Urothelial Carcinoma of the Urinary Bladder. Clin Cancer Res. 2017;23:503-513 pubmed publisher
    ..were performed to elucidate the role of the EGFR and STAT3 in CDDP-induced CCAAT/enhancer-binding protein delta (CEBPD) expression in UCUB cells...
  43. Michel L, Huguet Lachon A, Gourdon G. Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development. PLoS ONE. 2015;10:e0137620 pubmed publisher
    ..These RNA foci sequester proteins from the MBNL family and deregulate CELF proteins...
  44. Kolyada A, Johns C, Madias N. Role of C/EBP proteins in hepatic and vascular smooth muscle transcription of human NHE1 gene. Am J Physiol. 1995;269:C1408-16 pubmed
    ..These results indicate that members of the C/EBP family of transcription factors are involved in the regulation of hepatic and vascular smooth muscle transcription of the human NHE1 gene...
  45. Tanaka K, Hirai T, Kodama D, Kondo H, Hamamura K, Togari A. α1B -Adrenoceptor signalling regulates bone formation through the up-regulation of CCAAT/enhancer-binding protein δ expression in osteoblasts. Br J Pharmacol. 2016;173:1058-69 pubmed publisher
    ..adrenoceptor agonist, increased the expression of the transcriptional factor CCAAT/enhancer-binding protein δ (Cebpd) in MC3T3-E1 osteoblastic cells...
  46. Mendoza Villanueva D, Balamurugan K, Ali H, Kim S, Sharan S, Johnson R, et al. The C/EBPδ protein is stabilized by estrogen receptor α activity, inhibits SNAI2 expression and associates with good prognosis in breast cancer. Oncogene. 2016;35:6166-6176 pubmed publisher
    ..progression, and signal in part through the transcription factor Ccaat/enhancer-binding protein δ (C/EBPδ, CEBPD), which has been shown to promote mesenchymal features and malignant progression of glioblastoma...
  47. Tregnago C, Manara E, Zampini M, Bisio V, Borga C, Bresolin S, et al. CREB engages C/EBP? to initiate leukemogenesis. Leukemia. 2016;30:1887-96 pubmed publisher
    ..We provide a novel in vivo model to perform high-throughput drug screening for AML cure improvement. ..
  48. Chen Y, Xue P, Hou Y, Zhang H, Zheng H, Zhou T, et al. Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes. Toxicol Appl Pharmacol. 2013;273:435-41 pubmed publisher
    ..The inhibition of ARE signaling may be a potential underlying mechanism by which INH attenuates cellular antioxidant response contributing to various complications. ..
  49. Cleutjens C, van Eekelen C, van Dekken H, Smit E, Hagemeijer A, Wagner M, et al. The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization. Genomics. 1993;16:520-3 pubmed identify C/EBP-like transcription factors expressed in the prostate, a cDNA homologous to the mouse C/EBP delta (CRP3) and the rat CELF gene was isolated...
  50. Louet J, Coste A, Amazit L, Tannour Louet M, Wu R, Tsai S, et al. Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Proc Natl Acad Sci U S A. 2006;103:17868-73 pubmed
    ..Collectively, these data suggest a crucial role for SRC-3 as an integrator of the complex transcriptional network controlling adipogenesis. ..
  51. Kanamori Y, Murakami M, Sugiyama M, Hashimoto O, Matsui T, Funaba M. Interleukin-1? (IL-1?) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein ? (C/EBP?) expression in hepatocytes. J Biol Chem. 2017;292:10275-10287 pubmed publisher
    ..In cooperation with the other pathways activated by inflammation, IL-1? pathway stimulation leads to excess production of hepcidin, which could be causative to anemia of inflammation. ..
  52. Sivko G, Sanford D, Dearth L, Tang D, DeWille J. CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control. J Cell Biochem. 2004;93:844-56 pubmed
    ..These results indicate that the human C/EBPdelta gene is controlled at multiple levels, consistent with a role for C/EBPdelta in cell cycle control and/or cell fate determination. ..
  53. Chu Y, Ko C, Wang S, Lin P, Wang H, Lin W, et al. Bortezomib-induced miRNAs direct epigenetic silencing of locus genes and trigger apoptosis in leukemia. Cell Death Dis. 2017;8:e3167 pubmed publisher
    ..In the present study, transcription factor CCAAT/enhancer binding protein delta (CEBPD) was responsive to the anticancer drug bortezomib, a clinical and highly selective drug for leukemia treatment, ..
  54. Lin S, Yeh H, Wang W, Ke H, Lin H, Hsu W, et al. MiR-193b Mediates CEBPD-Induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells. J Cell Biochem. 2017;118:1563-1573 pubmed publisher
    Transcription factor CCAAT/enhancer-binding protein delta (CEBPD) plays multiple roles in tumor progression. Studies have demonstrated that cisplatin (CDDP) induced CEBPD expression and had led to chemotherapeutic drug resistance...
  55. Hogan N, Whalen M, Stolze L, Hadeli N, Lam M, Springstead J, et al. Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells. elife. 2017;6: pubmed publisher
    ..cytokines results in signal-specific alterations in enhancer landscapes and associate with coordinated binding of CEBPD, IRF1, and NF?B...
  56. Wang J, Liu Y, Su Z, Pan L, Lu F, Qu J, et al. The T-Box Transcription Factor TBX2 Regulates Cell Proliferation in the Retinal Pigment Epithelium. Curr Eye Res. 2017;42:1537-1544 pubmed publisher particular, by an increase in the levels of the tumor-suppressor gene CCAAT/enhancer-binding protein delta (CEBPD)...
  57. Yamaguchi J, Tanaka T, Eto N, Nangaku M. Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ. Kidney Int. 2015;88:262-75 pubmed publisher
    ..We report that CCAAT/enhancer-binding protein δ (CEBPD), a transcription factor and inflammatory response gene, is a novel HIF-1 regulator in kidney...
  58. Gangwani M, Kumar A. Multiple Protein Kinases via Activation of Transcription Factors NF-κB, AP-1 and C/EBP-δ Regulate the IL-6/IL-8 Production by HIV-1 Vpr in Astrocytes. PLoS ONE. 2015;10:e0135633 pubmed publisher
    ..Understanding the molecular pathways involved in the HIV-1 neuroinflammation would be helpful in the design of adjunct therapy to ameliorate some of the symptoms associated with HIV-1 neuropathogenesis. ..
  59. Chu Y, Ko C, Wang W, Wang S, Gean P, Kuo Y, et al. Astrocytic CCAAT/Enhancer Binding Protein δ Regulates Neuronal Viability and Spatial Learning Ability via miR-135a. Mol Neurobiol. 2016;53:4173-4188 pubmed publisher
    ..The AppTg/Cebpd (-/-) mice showed a spatial learning improvement compared with the APPswe/PS1/E9 bigenic (AppTg) mice...
  60. Chen Y, Hubal M, Hoffman E, Thompson P, Clarkson P. Molecular responses of human muscle to eccentric exercise. J Appl Physiol (1985). 2003;95:2485-94 pubmed
  61. Shah V, Dominic E, Moseley P, Pickett G, Fleet M, Ness S, et al. Hemodialysis modulates gene expression profile in skeletal muscle. Am J Kidney Dis. 2006;48:616-28 pubmed
    ..Reverse-transcription polymerase chain reaction confirmed increased expression of GADD45A, BTG2, PDE4B, and CEBPD and downregulation of TOB1 in skeletal muscle intradialysis...
  62. Gibellini D, Alviano F, Miserocchi A, Tazzari P, Ricci F, Clo A, et al. HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells. Retrovirology. 2011;8:40 pubmed publisher
    ..The HIV-related derangement of MSC survival and differentiation may suggest a direct role of HIV infection and gp120 in impaired vessel homeostasis and in genesis of vessel damage observed in HIV-infected patients. ..
  63. Zhou S, DeWille J. Proteasome-mediated CCAAT/enhancer-binding protein delta (C/EBPdelta) degradation is ubiquitin-independent. Biochem J. 2007;405:341-9 pubmed
    ..However, C/EBPdelta protein stability is not influenced by H2O2 treatment. In conclusion, our results demonstrate that proteasome-mediated protein degradation of C/EBPdelta is ubiquitin-independent. ..
  64. Kaji H, Fukano C, Kimura Y, Takiguchi E, Tanida K. Genetic variations at the CCAAT/enhancer-binding protein delta are associated with metabolic phenotypes in the Japanese population. Metab Syndr Relat Disord. 2008;6:24-31 pubmed publisher
    ..Regarding 394C>G, no association between the genotype and metabolic phenotypes was detected. Results suggest that genetic variations in the C/EBP-delta might play a role in some metabolic phenotypes. ..
  65. Payne V, Au W, Lowe C, Rahman S, Friedman J, O Rahilly S, et al. C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis. Biochem J. 2009;425:215-23 pubmed publisher
    ..Moreover, the findings of the present study identify an important additional mechanism via which the C/EBP transcription factors may control a network of gene expression regulating adipogenesis, lipogenesis and insulin sensitivity. ..