CEACAM6

Summary

Gene Symbol: CEACAM6
Description: carcinoembryonic antigen related cell adhesion molecule 6
Alias: CD66c, CEAL, NCA, carcinoembryonic antigen-related cell adhesion molecule 6, Cluster of Differentiation 66c, carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen), normal cross-reacting antigen
Species: human
Products:     CEACAM6

Top Publications

  1. Wang Y, Gangeswaran R, Zhao X, Wang P, Tysome J, Bhakta V, et al. CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells. J Clin Invest. 2009;119:1604-15 pubmed publisher
    ..Here we have identified carcinoembryonic antigen- related cell adhesion molecule 6 (CEACAM6) as a cellular protein that restricts the ability of adenoviral vectors to infect cancer cells...
  2. Skubitz K, Skubitz A. Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells. J Transl Med. 2008;6:78 pubmed publisher
    ..Four members of this family, CEACAM1, CEACAM8, CEACAM6, and CEACAM3 (recognized by CD66a, CD66b, CD66c, and CD66d mAbs, respectively), are expressed on human ..
  3. Watt S, Fawcett J, Murdoch S, Teixeira A, Gschmeissner S, Hajibagheri N, et al. CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant. Blood. 1994;84:200-10 pubmed
    ..least three carcinoembryonic antigen (CEA) superfamily members, ie, CEA itself, nonspecific cross-reacting antigen (NCA), and CGM1, but not to CGM6 (NCA-95)...
  4. Chen J, Li Q, An Y, Lv N, Xue X, Wei J, et al. CEACAM6 induces epithelial-mesenchymal transition and mediates invasion and metastasis in pancreatic cancer. Int J Oncol. 2013;43:877-85 pubmed publisher
    ..Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is emerging as an important determinant of the malignant phenotype in a range of cancers, including pancreatic ..
  5. Oikawa S, Inuzuka C, Kuroki M, Arakawa F, Matsuoka Y, Kosaki G, et al. A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. J Biol Chem. 1991;266:7995-8001 pubmed
    ..Chinese hamster ovary cells transfected with the cDNA for W272, CEA, nonspecific cross-reacting antigen (NCA), and various antigens containing chimeric N-domain have been used...
  6. Singer B, Scheffrahn I, Heymann R, Sigmundsson K, Kammerer R, Obrink B. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocyt. J Immunol. 2002;168:5139-46 pubmed
    ..We compared the expression patterns of CEACAM1-L, CEACAM1-S, CEACAM6, and CEACAM8 in purified populations of neutrophilic granulocytes, B lymphocytes, and T lymphocytes from rats, ..
  7. Jantscheff P, Terracciano L, Lowy A, Glatz Krieger K, Grunert F, Micheel B, et al. Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance. J Clin Oncol. 2003;21:3638-46 pubmed
    b>CEACAM6, CEACAM1, and human carcinoembryonic antigen (CEA) are coexpressed in normal colorectal epithelia, but show deregulated expression in colorectal cancers (CRC)...
  8. Stanke F, Becker T, Hedtfeld S, Tamm S, Wienker T, Tummler B. Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6. Hum Genet. 2010;127:383-94 pubmed publisher
    ..Annotation of these variants indicate that CEACAM6 and a regulatory element near the 3' end of CEACAM3 are associated with CF disease severity and intrapair ..
  9. Duxbury M, Ito H, Benoit E, Ashley S, Whang E. CEACAM6 is a determinant of pancreatic adenocarcinoma cellular invasiveness. Br J Cancer. 2004;91:1384-90 pubmed
    ..The immunoglobulin superfamily member carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is emerging as an important determinant of the malignant phenotype in a range of cancers...

More Information

Publications98

  1. Kim K, Kim J, Lee S, Kang M, Choe I, Kang Y, et al. Overexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer. Clin Chim Acta. 2013;415:12-9 pubmed publisher
    Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) inhibits anoikis and affects the malignant phenotype of cancer cells...
  2. Kolla V, Gonzales L, Bailey N, Wang P, Angampalli S, Godinez M, et al. Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell protein. Am J Physiol Lung Cell Mol Physiol. 2009;296:L1019-30 pubmed publisher
    Carcinoembryonic cell adhesion molecule 6 (CEACAM6) is a glycosylated, glycosylphosphatidylinositol (GPI)-anchored protein expressed in epithelial cells of various human tissues...
  3. Callaghan M, Rockett K, Banner C, Haralambous E, Betts H, Faust S, et al. Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease. Genes Immun. 2008;9:30-7 pubmed
    ..Two haplotypes were protective while one haplotype in CEACAM6 was associated with a twofold increase in disease susceptibility...
  4. Han S, Kwak T, Her K, Cho Y, Choi C, Lee H, et al. CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling. Oncogene. 2008;27:675-83 pubmed
    ..Expression patterns of CEA proteins correlated well with the level of CEA (CEACAM5) and CEACAM6 transcripts in these cell lines, but CEACAM1 expression was not observed in all of these cells...
  5. Camacho Leal P, Zhai A, Stanners C. A co-clustering model involving alpha5beta1 integrin for the biological effects of GPI-anchored human carcinoembryonic antigen (CEA). J Cell Physiol. 2007;211:791-802 pubmed
    ..These changes may represent a molecular mechanism for the biological effects of CEA. ..
  6. Ordonez C, Zhai A, Camacho Leal P, DeMarte L, Fan M, Stanners C. GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction. J Cell Physiol. 2007;210:757-65 pubmed
    Carcinoembryonic antigen (CEA) and CEA family member CEACAM6 are glycophosphatidyl inositol (GPI)-anchored, intercellular adhesion molecules that are up-regulated in a wide variety of human cancers, including colon, breast, and lung...
  7. Berger C, Billker O, Meyer T, Servin A, Kansau I. Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC). Mol Microbiol. 2004;52:963-83 pubmed
    ..named here Afa/Dr-I, including Dr, F1845 and AfaE-III adhesins, bound onto CHO cells expressing CEACAM1, CEA or CEACAM6. Whereas all the Afa/Dr adhesins elicit recruitment of CD55 around adhering bacteria, only the Afa/Dr-I subfamily ..
  8. Duxbury M, Ito H, Ashley S, Whang E. CEACAM6 as a novel target for indirect type 1 immunotoxin-based therapy in pancreatic adenocarcinoma. Biochem Biophys Res Commun. 2004;317:837-43 pubmed
    ..targeting the immunoglobulin superfamily member carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)...
  9. Duxbury M, Ito H, Zinner M, Ashley S, Whang E. CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. Oncogene. 2004;23:465-73 pubmed
    ..Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an immunoglobulin superfamily member overexpressed in a number of human cancers and implicated in anoikis ..
  10. Ilantzis C, DeMarte L, Screaton R, Stanners C. Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia. 2002;4:151-63 pubmed
    Human carcinoembryonic antigen (CEA) and the CEA family member CEACAM6 (formerly nonspecific cross-reacting antigen [NCA]) function in vitro, at least, as homotypic intercellular adhesion molecules and, in model systems, can block the ..
  11. Gaur P, Ranjan P, Sharma S, Patel J, Bowzard J, Rahman S, et al. Influenza A virus neuraminidase protein enhances cell survival through interaction with carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein. J Biol Chem. 2012;287:15109-17 pubmed publisher
    ..signaling axis via an interaction with carcinoembryonic antigen-related cell adhesion molecule 6/cluster of differentiation 66c (C6)...
  12. Schölzel S, Zimmermann W, Schwarzkopf G, Grunert F, Rogaczewski B, Thompson J. Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Pathol. 2000;156:595-605 pubmed
    Four members of the carcinoembryonic antigen (CEA) family, CEA, CEACAM1 (BGP), CEACAM6 (NCA-50/90), and CEACAM7 (CGM2), are coexpressed in normal colorectal epithelia but are deregulated in colorectal cancers, where they could play a ..
  13. Honda Y, Egawa K, Kuroki M, Ono T. Hair cycle-dependent expression of a nonspecific cross reacting antigen (NCA)-50/90-like molecule on follicular keratinocytes. Arch Dermatol Res. 1997;289:457-65 pubmed
    ..Immunohistochemically, the antigen resembled the nonspecific crossreacting antigen (NCA) NCA-50/90 rather than true CEA...
  14. Chapin C, Bailey N, Gonzales L, Lee J, Gonzalez R, Ballard P. Distribution and surfactant association of carcinoembryonic cell adhesion molecule 6 in human lung. Am J Physiol Lung Cell Mol Physiol. 2012;302:L216-25 pubmed publisher
    Carcinoembryonic cell adhesion molecule 6 (CEACAM6) is a glycosylated, glycophosphatidylinositol-anchored protein expressed in epithelial cells of various primate tissues...
  15. Duxbury M, Ito H, Benoit E, Zinner M, Ashley S, Whang E. Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. Oncogene. 2004;23:5834-42 pubmed
    Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers...
  16. Muenzner P, Rohde M, Kneitz S, Hauck C. CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells. J Cell Biol. 2005;170:825-36 pubmed
    ..The exploitation of CEACAMs to trigger CD105 expression and to counteract infection-induced cell detachment represents an intriguing adaptation of pathogens that are specialized to colonize the human mucosa. ..
  17. Blumenthal R, Leon E, Hansen H, Goldenberg D. Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers. BMC Cancer. 2007;7:2 pubmed
    Many breast, pancreatic, colonic and non-small-cell lung carcinoma lines express CEACAM6 (NCA-90) and CEACAM5 (carcinoembryonic antigen, CEA), and antibodies to both can affect tumor cell growth in vitro and in vivo...
  18. Barnich N, Carvalho F, Glasser A, Darcha C, Jantscheff P, Allez M, et al. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest. 2007;117:1566-74 pubmed
    ..type 1 pili expression on the bacterial surface and on carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) expression on the apical surface of ileal epithelial cells...
  19. Zhang Y, Zang M, Li J, Ji J, Zhang J, Liu X, et al. CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer. Acta Biochim Biophys Sin (Shanghai). 2014;46:283-90 pubmed publisher
    Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) shows increased expression in a wide variety of human cancers, and its over-expression is associated with enhanced migration, invasion, and in vivo metastasis...
  20. Martinez N, Rodney R, Block E, Hernandez L, Nelson C, Lean I, et al. Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows: Health and reproductive responses. J Dairy Sci. 2018;101:2563-2578 pubmed publisher
    ..positive DCAD with calcidiol (PCA), negative DCAD with cholecalciferol (NCH), and negative DCAD with calcidiol (NCA), which were fed from 252 d of gestation to calving...
  21. Dreux N, del Mar Cendra M, Massier S, Darfeuille Michaud A, Barnich N, Torrents E. Ribonucleotide reductase NrdR as a novel regulator for motility and chemotaxis during adherent-invasive Escherichia coli infection. Infect Immun. 2015;83:1305-17 pubmed publisher
    ..RNR, respectively, decreased AIEC LF82's ability to colonize the gut mucosa of transgenic mice that express human CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6)...
  22. Koyama S, Takamizawa A, Sato E, Masubuchi T, Nagai S, Izumi T. Cyclophosphamide stimulates lung fibroblasts to release neutrophil and monocyte chemoattractants. Am J Physiol Lung Cell Mol Physiol. 2001;280:L1203-11 pubmed
    ..Molecular-sieve column chromatography revealed that both neutrophil (NCA) and monocyte (MCA) chemotactic activities had multiple peaks...
  23. Rico Ramírez A, Roberson R, Riquelme M. Imaging the secretory compartments involved in the intracellular traffic of CHS-4, a class IV chitin synthase, in Neurospora crassa. Fungal Genet Biol. 2018;117:30-42 pubmed publisher
    ..The organization of the NEC was dependent on the cytoskeleton. SEC-63, an extensively used ER marker, and NCA-1, a SERCA-type ATPase previously localized at the nuclear envelope, were used as markers to discern the nature of ..
  24. Meng J, Zhang X, Liu X, Fan L, Li C, Sun Y, et al. WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways. Cell Signal. 2016;28:1673-82 pubmed publisher
    ..expression of EMT (epithelial to mesenchymal transition) marker fibronectin (FN1) and EMT-inducing genes Fos and CEACAM6. The changes of EMT markers including downregulated E-cadherin and upregulated N-cadherin and FN1 were further ..
  25. Zhang L, Wei T, Li Y, Li J, Fan Y, Huang F, et al. Functional Metabolomics Characterizes a Key Role for N-Acetylneuraminic Acid in Coronary Artery Diseases. Circulation. 2018;137:1374-1390 pubmed publisher
    ..Functional metabolomics identified a key role for Neu5Ac in acute myocardial infarction, and targeting neuraminidase-1 may represent an unrecognized therapeutic intervention for CAD. ..
  26. Ding J, Zheng X, Zhou T, Tong X, Luo C, Wang X. HMGB1Modulates the Treg/Th17 Ratio in Atherosclerotic Patients. J Atheroscler Thromb. 2016;23:737-45 pubmed publisher
    ..RORC mRNA were significantly increased in coronary atherosclerosis (AS) group compared to normal coronary artery (NCA) group (P<0.01)...
  27. Sánchez Ortiga R, Climent V, Sánchez Tejada L, Candela A, Pico A. Severe sleep apnea-hypopnea syndrome is related to left ventricle dysfunction and hypertrophy in acromegalic patients. Endocrinol Nutr. 2015;62:366-72 pubmed publisher
    ..A descriptive, cross-sectional study of 32 patients with acromegaly (15 categorized as non-controlled-NCA and 17 as controlled-CA) compared to 20 matched controls (by sex, age, and BMI) referred to the pulmonology ..
  28. Soylu K, Aksan G, Nar G, Özdemir M, Gülel O, İnci S, et al. Serum neutrophil gelatinase-associated lipocalin levels are correlated with the complexity and the severity of atherosclerosis in acute coronary syndrome. Anatol J Cardiol. 2015;15:450-5 pubmed publisher
    ..Forty-seven random NSTE-ACS patients and 45 patients with normal coronary arteries (NCA) who underwent coronary angiography were enrolled in the study...
  29. Flourakis M, Kula Eversole E, Hutchison A, Han T, Aranda K, Moose D, et al. A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Cell. 2015;162:836-48 pubmed publisher
    ..This current is driven by the rhythmic expression of NCA localization factor-1, linking the molecular clock to ion channel function...
  30. He X, Fan J, Wooley K. Stimuli-Triggered Sol-Gel Transitions of Polypeptides Derived from α-Amino Acid N-Carboxyanhydride (NCA) Polymerizations. Chem Asian J. 2016;11:437-47 pubmed publisher
  31. Naghibalhossaini F, Sayadi K, Jaberie H, Bazargani A, Eftekhar E, Hosseinzadeh M. Inhibition of CEA release from epithelial cells by lipid A of Gram-negative bacteria. Cell Mol Biol Lett. 2015;20:374-84 pubmed publisher
    ..The GPI-linked CEA and CEACAM6 might play a role in the innate immune defense, protecting the colon from microbial invasion...
  32. Wu A, Xu D, Yang N, Lin S, Chen P, Cala S, et al. Phospholamban is concentrated in the nuclear envelope of cardiomyocytes and involved in perinuclear/nuclear calcium handling. J Mol Cell Cardiol. 2016;100:1-8 pubmed publisher
    ..whether a pool of PLB exists in the nuclear envelope (NE) that might regulate perinuclear/nuclear Ca2+ (nCa2+) handling in cardiomyocytes (CMs)...
  33. Jin C, Liu Y, Zhu J, Xia T, Zhang B, Fei Y, et al. Recombinant Salmonella-based CEACAM6 and 4-1BBL vaccine enhances T-cell immunity and inhibits the development of colorectal cancer in rats: In vivo effects of vaccine containing 4-1BBL and CEACAM6. Oncol Rep. 2015;33:2837-44 pubmed publisher
    The present study aimed to determine the effect of recombinant Salmonella (SL3261)-based CEACAM6 and 4-1BB ligand (4-1BBL) vaccine on the development of colorectal cancer in rats and the potential immune mechanisms involved...
  34. Bi Y, Xiao D, Ren S, Bi S, Wang J, Li F. The Binary System of Ibuprofen-Nicotinamide Under Nanoscale Confinement: From Cocrystal to Coamorphous State. J Pharm Sci. 2017;106:3150-3155 pubmed publisher
    ..to confine a binary mixture of drug and coformer (CF) within nanopores to obtain a nanoconfined coamorphous (NCA) system...
  35. Stiel S, Heckel M, Seifert A, Frauendorf T, Hanke R, Ostgathe C. Comparison of terminally ill cancer- vs. non-cancer patients in specialized palliative home care in Germany - a single service analysis. BMC Palliat Care. 2015;14:34 pubmed publisher
    ..death statistics into account, PC in Europe will face a growing number of patients dying from non-cancer diseases (NCA). More insights into specialized palliative home care (SPHC) in NCAs are needed...
  36. Solomon S, Lucas G, Celentano D, McFall A, Ogburn E, Moulton L, et al. Design of the Indian NCA study (Indian national collaboration on AIDS): a cluster randomized trial to evaluate the effectiveness of integrated care centers to improve HIV outcomes among men who have sex with men and persons who inject drugs in India. BMC Health Serv Res. 2016;16:652 pubmed
    ..Trials need to be designed to optimize utilization of services in these populations. ClinicalTrials.gov Identifier: NCT01686750 Date of Registration: September 13, 2012. ..
  37. Yılmaz M, Dagli M, Uku O, Bilen M, Korkmaz H, Erdem K, et al. Focusing on a complete blood cell parameter: mean platelet volume levels may be a predictor of coronary slow flow. Vasc Health Risk Manag. 2017;13:255-261 pubmed publisher
    ..In the present study, MPV in patients with coronary slow flow (CSF) and in cases with normal coronary anatomy (NCA) was investigated and compared with the aim of identifying the relationship between CSF and MPV...
  38. Owaidah T, Rawas F, Al Khayatt M, Elkum N. Expression of CD66c and CD25 in acute lymphoblastic leukemia as a predictor of the presence of BCR/ABL rearrangement. Hematol Oncol Stem Cell Ther. 2008;1:34-7 pubmed
    ..b>CD66c is a myeloid marker which has aberrant expression in pre-B cell ALL, with strong correlation with non-random ..
  39. Corrente F, Bellesi S, Metafuni E, Puggioni P, Marietti S, Ciminello A, et al. Role of flow-cytometric immunophenotyping in prediction of BCR/ABL1 gene rearrangement in adult B-cell acute lymphoblastic leukemia. Cytometry B Clin Cytom. 2017;: pubmed publisher
    ..Patients with gene rearrangement had a greater frequency of CD66c, CD13 and CD33 positivity compared with BCR/ABL1-negative cases...
  40. Jay M, Thomas B, Nandi R, Howard R. Higher risk of opioid-induced respiratory depression in children with neurodevelopmental disability: a retrospective cohort study of 12 904 patients. Br J Anaesth. 2017;118:239-246 pubmed publisher
    ..We aimed to quantify the risks and effectiveness of morphine nurse-controlled analgesia (morphine-NCA) for postoperative pain in children with neurodevelopmental disabilities...
  41. Martinez N, Rodney R, Block E, Hernandez L, Nelson C, Lean I, et al. Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows: Lactation performance and energy metabolism. J Dairy Sci. 2018;101:2544-2562 pubmed publisher
    ..positive DCAD with CH (PCH), positive DCAD with CA (PCA), negative DCAD with CH (NCH), or negative DCAD with CA (NCA), which were fed for the last 21 d of gestation. After calving, cows were fed the same lactation diet...
  42. Liu K, Li T, Huang S, Long R, You Y, Liu J, et al. The reduced soluble fibrinogen-like protein 2 and regulatory T cells in acute coronary syndrome. Exp Biol Med (Maywood). 2016;241:421-5 pubmed publisher
    ..acute coronary syndrome (ACS) patients, together with 22 stable angina (SA) patients and 31 normal coronary artery (NCA) people were enrolled in our study. Serum level of sfgl2 and plasma level of Treg were respectively measured...
  43. Guryanov I, Polo F, Ubyvovk E, Korzhikova Vlakh E, Tennikova T, Rad A, et al. Polylysine-grafted Au144 nanoclusters: birth and growth of a healthy surface-plasmon-resonance-like band. Chem Sci. 2017;8:3228-3238 pubmed publisher
    ..Linear polylysine chains were grown by direct N-carboxyanhydride (NCA) polymerization onto ligands capping the gold nanocluster...
  44. Nakao T. Mechanisms of resistance to insecticides targeting RDL GABA receptors in planthoppers. Neurotoxicology. 2017;60:293-298 pubmed publisher
    ..Fipronil is a second-generation NCA, but A2'S and A2'G mutations provide a low level of cross-resistance to fipronil...
  45. Al Safadi S, Branchaud M, Rutherford S, Amir S. Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain. PLoS ONE. 2015;10:e0130085 pubmed publisher
    ..in the oval nucleus of the bed nucleus of the stria terminalis (BNSTov) and the central nucleus of the amygdala (CEAl), whereas 2DG increased PER1 in both regions...
  46. Tawaragi Y, Oikawa S, Matsuoka Y, Kosaki G, Nakazato H. Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence. Biochem Biophys Res Commun. 1988;150:89-96 pubmed
    ..library of HLC-1 cells by immunochemical screening with the antibody specific to nonspecific crossreacting antigen (NCA)...
  47. Lasa A, Serrano E, Carricondo M, Carnicer M, Brunet S, Badell I, et al. High expression of CEACAM6 and CEACAM8 mRNA in acute lymphoblastic leukemias. Ann Hematol. 2008;87:205-11 pubmed
    ..All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes. These results were confirmed by dilutional experiments...
  48. Bryk G, Coronel M, Lugones C, Mandalunis P, Rio M, Gualtieri A, et al. Effect of a mixture of GOS/FOS® on calcium absorption and retention during recovery from protein malnutrition: experimental model in growing rats. Eur J Nutr. 2016;55:2445-2458 pubmed
    ..The effect of a mixture of GOS/FOS® 9:1 added to a 0.5 %Ca (NCa) and a 0...
  49. Huston P, Hoover D. Treatment of symptomatic convergence insufficiency with home-based computerized vergence system therapy in children. J AAPOS. 2015;19:417-21 pubmed publisher
    ..Near point of convergence (NPC) and near convergence amplitude (NCA) were measured at baseline, 6 week, and final examinations...
  50. Sylvia L, Chang W, Kamali M, Tohen M, Kinrys G, Deckersbach T, et al. Sleep disturbance may impact treatment outcome in bipolar disorder: A preliminary investigation in the context of a large comparative effectiveness trial. J Affect Disord. 2018;225:563-568 pubmed publisher
    ..Medication changes were recorded as necessary clinical adjustments (NCA)...
  51. Azadbakht B, Afarideh H, Ghannadi Maragheh M, Asgari M, Bahrami Samani A. Development of an electrochemical 188W/188Re generator as a technique for separation and purification of 188Re in radiopharmaceutical applications. Appl Radiat Isot. 2016;118:331-337 pubmed publisher
    ..for separation and purification of 188Re from 188W to obtain no carrier added (NCA) 188Re is developed...
  52. Yan L, Wang Y, Wang Z, Rong Y, Chen L, Li Q, et al. Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma. Oncol Rep. 2016;35:418-26 pubmed publisher
    Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family...
  53. Le Fer G, Portes D, Goudounet G, Guigner J, Garanger E, Lecommandoux S. Design and self-assembly of PBLG-b-ELP hybrid diblock copolymers based on synthetic and elastin-like polypeptides. Org Biomol Chem. 2017;15:10095-10104 pubmed publisher
    ..ELP) block used as a macroinitiator for the ring opening polymerization (ROP) of γ-benzyl-l-glutamate (γ-BLG NCA) are herein presented...
  54. Belharazem D, Magdeburg J, Berton A, Beissbarth L, Sauer C, Sticht C, et al. Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications. J Gastroenterol. 2016;51:971-84 pubmed publisher
    ..of IGF2 in cell lines revealed that IGF2 induced distinct sets of activated and repressed genes, including Wnt5a, CEACAM6, IGF2BP3, KPN2A, BRCA2, and CDK1...
  55. Glas J, Seiderer J, Fries C, Tillack C, Pfennig S, Weidinger M, et al. CEACAM6 gene variants in inflammatory bowel disease. PLoS ONE. 2011;6:e19319 pubmed publisher
    The carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) acts as a receptor for adherent-invasive E. coli (AIEC) and its ileal expression is increased in patients with Crohn's disease (CD)...
  56. Zhou P, Zhang Z, Meng H, Lu Y, Cao J, Cheng F, et al. SiO2-coated LiNi0.915Co0.075Al0.01O2 cathode material for rechargeable Li-ion batteries. Nanoscale. 2016;8:19263-19269 pubmed
    ..915Co0.075Al0.01O2 (NCA) cathode materials...
  57. Radchenko V, Meyer C, Engle J, Naranjo C, Unc G, Mastren T, et al. Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system. J Chromatogr A. 2016;1477:39-46 pubmed publisher
    ..Recovery and purification of no-carrier added (nca) 44Ti from scandium metal targets involves complex separation chemistry...
  58. Mahata P. Biomarkers for epithelial ovarian cancers. Genome Inform. 2006;17:184-93 pubmed
    ..We obtain the genes HNF1-beta (TCF2) and GGT1 as the best markers for the clear cell and CEACAM6 (NCA) as the best marker for mucinous ovarian tumors...
  59. Rodia M, Ugolini G, Mattei G, Montroni I, Zattoni D, Ghignone F, et al. Systematic large-scale meta-analysis identifies a panel of two mRNAs as blood biomarkers for colorectal cancer detection. Oncotarget. 2016;7:30295-306 pubmed publisher
    ..The expression of genes: TSPAN8, LGALS4, COL1A2 and CEACAM6 resulted as being statistically different.In particular ROC curves attested for TSPAN8 an AUC of 0...
  60. Greenhouse I, Babushkin F, Finn T, Shimoni Z, Aliman M, Ben Ami R, et al. Long-term outcomes of inappropriate antibiotic therapy for upper urinary tract infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae: a retrospective cohort study. Diagn Microbiol Infect Dis. 2017;89:222-229 pubmed publisher
    ..definitive treatment with a carbapenem (CP), (2) a microbiologically appropriate intravenous non-carbapenem agent (NCA), (3) a non-appropriate antimicrobial (NAA), and (4) an intravenous NAA followed by an oral NCA (NAA-PO)...
  61. Hasselbalch H, Skov V, Larsen T, Thomassen M, Riley C, Jensen M, et al. High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis. Leuk Res. 2011;35:1330-4 pubmed publisher
    ..In PMF patients, the CEACAM6 and 8 were significantly upregulated (fold change (FC) 12.5 and 14.0, respectively and FDR adjusted p values 7...
  62. Herbert J, Walsh W, Bromfield L. A national survey of characteristics of child advocacy centers in the United States: Do the flagship models match those in broader practice?. Child Abuse Negl. 2018;76:583-595 pubmed publisher
    ..Directors of CACs in the United States that were members of the National Children's Alliance (NCA) mailing list (n=361) completed an online survey in 2016...
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    ..however, we show that introducing any of the Opa-binding CEACAMs of human neutrophils (CEACAM1, CEACAM3, and CEACAM6) allows binding and entry of Neisseria into murine neutrophils...
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    ..Several family members, including CEACAM1, CEA, and CEACAM6, are found on epithelial tissues throughout the human body...
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    ..were randomly distributed into four groups with six animals each in a 2x2 factorial design namely, normal-Ca diet (NCa) and low-Ca diet (LCa) fed without or with 40 ppm B (NCaB-40 and LCaB-40)...
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    Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an important regulator of cell adhesion, invasion, and metastasis...
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    ..The conjugates were prepared via N-carboxy anhydride (NCA)-mediated ring-opening polymerization from PEO star polymer macroinitiators...
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    ..Blasts were positive for CD10, CD19, CD20, CD34, cyCD79a, cyTdT, HLA-DR, and CD66c, had a karyotype of 45, XX, - 7 [18/20] and a split signal for ABL1 FISH probe (92...
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    The photonuclear production of no-carrier-added (NCA) 47Sc from solid NatTiO2 and the subsequent chemical processing and purification have been developed...
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    In 1971, President Nixon signed into law the National Cancer Act (NCA), colloquially known as the "War on Cancer", which pushed cancer onto the national agenda and is credited for many subsequent increases in the knowledge of the ..
  74. Topalidou I, Chen P, Cooper K, Watanabe S, Jorgensen E, Ailion M. The NCA-1 and NCA-2 Ion Channels Function Downstream of Gq and Rho To Regulate Locomotion in Caenorhabditis elegans. Genetics. 2017;206:265-282 pubmed publisher
    ..in the nematode Caenorhabditis elegans Through two forward genetic screens, we identify the cation channels NCA-1 and NCA-2, orthologs of mammalian NALCN, as downstream targets of the Gq-Rho pathway...
  75. Javaheri A, Kruse T, Moonens K, Mejías Luque R, Debraekeleer A, Asche C, et al. Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs. Nat Microbiol. 2016;2:16189 pubmed publisher
    ..and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. HopQ-CEACAM binding is glycan-independent and targeted to the N-domain. H...
  76. Kalina T, Vaskova M, Mejstrikova E, Madzo J, Trka J, Stary J, et al. Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens. BMC Cancer. 2005;5:38 pubmed
    ..Granulocytic marker CD66c -- Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is aberrantly expressed on ALL with strong correlation to genotype (negative in TEL/AML1 and MLL/AF4, positive ..
  77. Zhao Z, Li L, Wang H, Wang Y. Expression and prognostic significance of CEACAM6, ITGB1, and CYR61 in peripheral blood of patients with gastric cancer. J Surg Oncol. 2011;104:525-9 pubmed publisher
    We examined CEACAM6, ITGB1, and cyr61 concentrations from patients with gastric cancers (GCs) to assess their clinical application for diagnosing and monitoring diseases...
  78. Gonzales L, Gonzalez R, Barrette A, Wang P, Dobbs L, Ballard P. Expression of Carcinoembryonic Cell Adhesion Molecule 6 and Alveolar Epithelial Cell Markers in Lungs of Human Infants with Chronic Lung Disease. J Histochem Cytochem. 2015;63:908-21 pubmed publisher
    The membrane protein carcinoembryonic antigen cell adhesion molecule (CEACAM6) is expressed in the epithelium of various tissues, participating in innate immune defense, cell proliferation and differentiation, with overexpression in ..
  79. Gillbro J, Al Bader T, Westman M, Olsson M, Mavon A. Transcriptional changes in organoculture of full-thickness human skin following topical application of all-trans retinoic acid. Int J Cosmet Sci. 2014;36:253-61 pubmed publisher
    ..The results in the present study show this model represent a valuable pre-clinical model for studying the effects of retinoids in skin. ..
  80. Balk Møller E, Kim J, Hopkinson B, Timmermans Wielenga V, Petersen O, Villadsen R. A marker of endocrine receptor-positive cells, CEACAM6, is shared by two major classes of breast cancer: luminal and HER2-enriched. Am J Pathol. 2014;184:1198-208 pubmed publisher
    ..by strong staining for endocrine receptors are also characterized by expression of the surface marker CEACAM6. Topographically, this pattern of staining predominates in terminal ductal lobular units, rather than in ..
  81. Tsang J, Kwok Y, Chan K, Ni Y, Chow W, Lau K, et al. Expression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in breast cancers. Breast Cancer Res Treat. 2013;142:311-22 pubmed publisher
    Carcino-embryonic antigen-related cell adhesion molecule 6 (CEACAM6), one of the members of human carcino-embryonic antigens, is a multifunctional regulatory protein involved in various cellular processes in cancers...
  82. Klaile E, Klassert T, Scheffrahn I, Müller M, Heinrich A, Heyl K, et al. Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and I. Respir Res. 2013;14:85 pubmed publisher
    The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung...
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    The molecular heterogeneity of nonspecific cross-reacting antigen (NCA) was examined...
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    ..CEAM6 measurement in bile could be clinically useful to discriminate between malignant and nonmalignant causes of biliary stenosis. This article is part of a Special Issue entitled: Biomarkers: A Proteomic Challenge. ..
  85. Keenan J, Hooper E, Tyrer P, Day A. Influences of enteral nutrition upon CEACAM6 expression by intestinal epithelial cells. Innate Immun. 2014;20:848-56 pubmed publisher
    ..b>CEACAM6 protein is an adhesion molecule that is up-regulated in active CD and implicated in the attachment of adherent-..
  86. Holmer R, Wätzig G, Tiwari S, Rose John S, Kalthoff H. Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells. BMC Cancer. 2015;15:975 pubmed publisher
    ..Its family member CEACAM6 is also upregulated in adenomas and carcinomas of the colon and an independent predictor of poor survival...
  87. Park U, Lee J, Choi K, Nam S, Yu K. Lu-177 preparation for radiotherapy application. Appl Radiat Isot. 2016;115:8-12 pubmed publisher
    A separation study using a (176)Yb target for the preparation of nca (177)Lu, which is a beta-emitting nuclide used not only in radioimmunotherapy applications but also in the treatment of various lesions, has been performed...
  88. Zang M, Hu L, Cao S, Fan Z, Pang L, Li J, et al. Dual role of carcinoembryonic antigen-related cell adhesion molecule 6 expression in predicting the overall survival of gastric cancer patients. Sci Rep. 2017;7:10773 pubmed publisher
    Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is a member of the glycosylphosphatidylinositol-linked immunoglobulin superfamily that is implicated in many human cancers...
  89. Zong L, Li X, Wang H, Cao Y, Yin L, Li M, et al. Formulation and characterization of biocompatible and stable I.V. itraconazole nanosuspensions stabilized by a new stabilizer polyethylene glycol-poly(?-Benzyl-l-aspartate) (PEG-PBLA). Int J Pharm. 2017;531:108-117 pubmed publisher
    ..It was found that the optimal length of hydrophobic block was 25 BLA-NCA molecules and the optimal ratio of drug/stabilizer was 1:1, where the resulted average particle size of ITZ-PBLA-..