CEACAM5

Summary

Gene Symbol: CEACAM5
Description: carcinoembryonic antigen related cell adhesion molecule 5
Alias: CD66e, CEA, carcinoembryonic antigen-related cell adhesion molecule 5, meconium antigen 100
Species: human
Products:     CEACAM5

Top Publications

  1. Eidelman F, Fuks A, DeMarte L, Taheri M, Stanners C. Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts. J Cell Biol. 1993;123:467-75 pubmed
    Human carcinoembryonic antigen (CEA), a widely used tumor marker, is a member of a family of cell surface glycoproteins that are overexpressed in many carcinomas...
  2. Ordonez C, Screaton R, Ilantzis C, Stanners C. Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Res. 2000;60:3419-24 pubmed
    Human carcinoembryonic antigen (CEA), a widely used tumor marker, and CEACAM6 [formerly nonspecific cross-reacting antigen (NCA)] are up-regulated in many types of human cancers, whereas family member CEACAM1 [formerly biliary ..
  3. Soeth E, Wirth T, List H, Kumbhani S, Petersen A, Neumaier M, et al. Controlled ribozyme targeting demonstrates an antiapoptotic effect of carcinoembryonic antigen in HT29 colon cancer cells. Clin Cancer Res. 2001;7:2022-30 pubmed
    Clinical studies suggest that carcinoembryonic antigen (CEA) is associated with metastatic progression of colon cancer. However, the biological function of CEA is not well understood...
  4. Wirth T, Soeth E, Czubayko F, Juhl H. Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth. Clin Exp Metastasis. 2002;19:155-60 pubmed
    It has been suggested that carcinoembryonic antigen (CEA) enhances metastatic seeding of colon cancer cells due to its homo- and heterophilic binding properties...
  5. Blumenthal R, Leon E, Hansen H, Goldenberg D. Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers. BMC Cancer. 2007;7:2 pubmed
    Many breast, pancreatic, colonic and non-small-cell lung carcinoma lines express CEACAM6 (NCA-90) and CEACAM5 (carcinoembryonic antigen, CEA), and antibodies to both can affect tumor cell growth in vitro and in vivo...
  6. Beauchemin N, Benchimol S, Cournoyer D, Fuks A, Stanners C. Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen. Mol Cell Biol. 1987;7:3221-30 pubmed
    Carcinoembryonic antigen (CEA) expression is perhaps the most prevalent of phenotypic changes observed in human cancer cells. The molecular genetic basis of this phenomenon, however, is completely unknown...
  7. Oikawa S, Nakazato H, Kosaki G. Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. Biochem Biophys Res Commun. 1987;142:511-8 pubmed
    ..to the mRNA encoding a polypeptide which is immunoreactive with the antisera specific to carcinoembryonic antigen (CEA) (1) are cloned...
  8. Hampton R, Walker M, Marshall J, Juhl H. Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells. Oncogene. 2002;21:7817-23 pubmed
    ..In colon cancer patients, carcinoembrynic antigen (CEA) and cytokeratin 20 (CK20) have been frequently used for RT-PCR based tumor cell detection, but the specificity in ..
  9. Beauchemin N, Arabzadeh A. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev. 2013;32:643-71 pubmed publisher
    ..Indeed, CEACAM1, CEACAM5, and CEACAM6 are now considered valid clinical biomarkers and promising therapeutic targets in melanoma, lung, ..

More Information

Publications137 found, 100 shown here

  1. Klaile E, Klassert T, Scheffrahn I, Müller M, Heinrich A, Heyl K, et al. Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and I. Respir Res. 2013;14:85 pubmed publisher
    The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung...
  2. Stulhofer Buzina D, Martinac I, Ledić Drvar D, Ceović R, Bilic I, Marinovic B. Adverse Reaction to Cetuximab, an Epidermal Growth Factor Receptor Inhibitor. Acta Dermatovenerol Croat. 2016;24:70-2 pubmed
    ..detected on multi-slice computer tomography (MSCT) images, with an increased value of the carcinoembryonic antigen (CEA) tumor marker (maximal value 57 ng/mL)...
  3. Fortofoiu M, Popescu D, Pădureanu V, Dobrinescu A, Dobrinescu A, Mită A, et al. Difficulty in positive diagnosis of ascites and in differential diagnosis of a pulmonary tumor. Rom J Morphol Embryol. 2017;58:1057-1064 pubmed
    ..molecule (Ep-CAM) (BerEP4), thyroid transcription factor-1 (TTF-1), E-cadherin, CDX2, carcinoembryonic antigen (CEA) and the Hector Battifora mesothelial antigen-1 (HBME-1)...
  4. Paolino G, Panetta C, Didona D, Donati M, Donati P. Folliculotropic Cutaneous Metastases and Lymphangitis Carcinomatosa: When Cutaneous Metastases of Breast Carcinoma Are Mistaken for Cutaneous Infections. Acta Dermatovenerol Croat. 2016;24:154-7 pubmed
    ..The tumor cells were positive to cytokeratin (CK) 7, CK19, and carcinoembryonic antigen (CEA) and negative for CK20, CK5/6, CD10, and thyroid transcription factor-1 (TTF-1) (Figure 4)...
  5. El Gendy M, Abdel Wahhab K, Mannaa F, Farghaly A, El Bondkly A. Carcinogenic Activities and Sperm Abnormalities of Methicillin Resistance Staphylococcus aureus and Inhibition of Their Virulence Potentials by Ayamycin. Appl Biochem Biotechnol. 2017;183:833-852 pubmed publisher
    ..elevation was recorded in serum levels of tumor biomarkers (alpha fetoprotein; AFP, carcinoembryonic antigen; CEA, and lactate dehydrogenase; LDH) reflecting their carcinogenic potential...
  6. Giessen Jung C, Nagel D, Glas M, Spelsberg F, Lau Werner U, Modest D, et al. Preoperative serum markers for individual patient prognosis in stage I-III colon cancer. Tumour Biol. 2015;36:7897-906 pubmed publisher
    Carcinoembryonic antigen (CEA) remains the only recommended biomarker for follow-up care of colorectal cancer (CRC), but besides CEA, several other serological parameters have been proposed as prognostic markers for CRC...
  7. Shi X, Huang C, Xiao F, Liu W, Zeng J, Li X. Pycnodysostosis with novel gene mutation and sporadic medullary thyroid carcinoma: A case report. Medicine (Baltimore). 2017;96:e8730 pubmed publisher
    ..elevated serum calcitonin >2000 pg/L (reference range: 0-5 pg/L) and carcinoembryonic antigen (CEA) 134.37 ng/mL (reference range: 0-5 ng/mL)...
  8. Zhao R, Wang X, Lan X, Li M. [Clinicopathologic characteristics and prognosis of gastric hepatoid adenocarcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi. 2017;20:1035-1039 pubmed
    ..All the patients underwent preoperative serum alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), endoscopy and imaging examination (CT or B-mode ultrasonography), and those with elevated AFP were excluded from ..
  9. Areias M, Prada P. Mechanisms of insulin resistance in the amygdala: influences on food intake. Behav Brain Res. 2015;282:209-17 pubmed publisher
    ..Overexpressed PKCθ in the CeA (central nucleus of amygdala) of rats increases weight gain, food intake, insulin resistance and hepatic ..
  10. Yi P, Jou S, Wu Y, Chang F. Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture. J Vis Exp. 2016;: pubmed publisher
    ..We administer pilocarpine into the left central nucleus of the amygdala (CeA) to simulate focal temporal lobe epilepsy (TLE) in rats...
  11. Harino T, Tomimaru Y, Noguchi K, Nagase H, Ogino T, Hirota M, et al. A case of intraductal papillary-mucinous neoplasm of the pancreas penetrating into the stomach and spleen successfully treated by total pancreatectomy. Surg Case Rep. 2018;4:117 pubmed publisher
    ..No malignancy was detected based on cytology of the mucin. Inflammation markers and tumor markers (CEA, CA19-9) were elevated in the blood...
  12. Raue F, Frank Raue K. Long-Term Follow-up in Medullary Thyroid Carcinoma. Recent Results Cancer Res. 2015;204:207-25 pubmed publisher
    ..the number of compartments involved, and the postoperative calcitonin (CTN) and carcinoembryonic antigen (CEA) levels should be documented...
  13. Zhao Z, Lu C, Li T, Wang W, Ye W, Zeng R, et al. The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: In vivo assessment and a randomized controlled trial. J Pineal Res. 2018;65:e12521 pubmed publisher
    Carotid endarterectomy (CEA) is the treatment of choice for carotid stenosis. Some patients develop ischemia and reperfusion (I/R) injury after CEA...
  14. Cetin S, Kir G, Yilmaz M. Thyroid Paraganglioma Diagnosed by Fine-Needle Aspiration Biopsy, Correlated With Histopathological Findings: Report of a Case. Diagn Cytopathol. 2016;44:643-7 pubmed publisher
    ..immunohistochemically stained with antibodies to thyroglobulin, calcitonin (CT), AE1-AE3, carcinoembryonic antigen (CEA), synaptophysin, chromogranin A (CH-A), neuron-specific enolase (NSE), thyroid transcription factor-1 (TTF-1), ..
  15. Niculescu Z, Ulmeanu V, Ghinea M, Mocanu L, Niculescu C, Grigorian M. Gallbladder carcinoma - a rare cause of pyloric-duodenal stenosis. Rom J Morphol Embryol. 2016;57:1165-1170 pubmed
    ..CK20, CDX2, mucin (MUC) 1, MUC2, MUC5AC, MUC6, epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA)] were consistent with infiltrating neoplastic carcinoma, originating in the gallbladder epithelium...
  16. Kasala E, Bodduluru L, Barua C, Gogoi R. Antioxidant and antitumor efficacy of Luteolin, a dietary flavone on benzo(a)pyrene-induced experimental lung carcinogenesis. Biomed Pharmacother. 2016;82:568-77 pubmed publisher
    ..to mice resulted in raised lipid peroxides (LPO), lung specific tumor markers such as carcinoembryonic antigen (CEA) and neuron specific enolase (NSE) with concomitant decrease in the levels of both enzymatic antioxidants such as ..
  17. Rodrigues A, Gravato C, Quintaneiro C, Golovko O, Žlábek V, Barata C, et al. Life history and biochemical effects of chlorantraniliprole on Chironomus riparius. Sci Total Environ. 2015;508:506-13 pubmed publisher
    ..Effects of CAP on cellular energy allocation (CEA) were also assessed. Acute tests revealed a 48 h LC50 for C. riparius of 77...
  18. Gruenbaum S, Wang H, Zaveri H, Tang A, Lee T, Eid T, et al. Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy. Epilepsy Behav. 2015;51:96-103 pubmed publisher
    ..in MTLE by testing the hypothesis that deficiency in glutamine synthetase in the central nucleus of the amygdala (CeA) leads to epilepsy and comorbid anhedonia...
  19. Gates L, Botta R, Schlosser F, Goodney P, Fokkema M, Schermerhorn M, et al. Characteristics that define high risk in carotid endarterectomy from the Vascular Study Group of New England. J Vasc Surg. 2015;62:929-36 pubmed publisher
    ..and Protection in Patients at High Risk for Endarterectomy (SAPPHIRE) trial compared carotid endarterectomy (CEA) to carotid artery stenting (CAS) among high-risk patients using a model of risk that has not been validated by ..
  20. Benvenuto M, Sileri P, Rossi P, Masuelli L, Fantini M, Nanni M, et al. Natural humoral immune response to ribosomal P0 protein in colorectal cancer patients. J Transl Med. 2015;13:101 pubmed publisher
    ..67 malignant and 5 benign tumors) were compared with 73 healthy donor sera for the presence of antibodies to CEA, EGFR, ErbB2 and ribosomal P proteins by western blotting or ELISA...
  21. Higuchi M, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, et al. FDG-PET in the evaluation of response to nivolumab in recurrent non-small-cell lung cancer. World J Surg Oncol. 2016;14:238 pubmed publisher
    ..Serum carcinoembryonic antigen (CEA) level was also remarkably decreased...
  22. Radak D, Tanaskovic S, Sagic D, Antonic Z, Gajin P, Babic S, et al. A Novel Antegrade Approach for Simultaneous Carotid Endarterectomy and Angioplasty of Proximal Lesions in Patients with Tandem Stenosis of Supraaortic Arch Vessels. Ann Vasc Surg. 2017;44:368-374 pubmed publisher
    ..the presented study, for the first time, antegrade approach is described for simultaneous carotid endarterectomy (CEA) and associated brachiocephalic trunk (BCT) or common carotid artery (CCA) angioplasty in the hybrid operating room...
  23. Tao L, Yang J, Gu Y, Zhou X, Zhao A, Zheng J, et al. Weichang'an and 5-fluorouracil suppresses colorectal cancer in a mouse model. World J Gastroenterol. 2015;21:1125-39 pubmed publisher
    ..Serum carcinoembryonic antigen (CEA) level was determined by ELISA...
  24. Javan B, Atyabi F, Shahbazi M. Hypoxia-inducible bidirectional shRNA expression vector delivery using PEI/chitosan-TBA copolymers for colorectal Cancer gene therapy. Life Sci. 2018;202:140-151 pubmed publisher
    ..To construct a pRNA-bipHRE-CEA vector, the carcinoma embryonic antigen (CEA) promoter designed in two directions and the vascular endothelial ..
  25. Fowler L, Maygarden S, Novotny D. Human alveolar macrophage-56 and carcinoembryonic antigen monoclonal antibodies in the differential diagnosis between primary ovarian and metastatic gastrointestinal carcinomas. Hum Pathol. 1994;25:666-70 pubmed
    The immunohistochemical expression and localization of monoclonal antibodies to carcinoembryonic antigen (CEA) and human alveolar macrophage (HAM-56) were evaluated in primary ovarian and metastatic gastrointestinal (GI) carcinomas...
  26. Chen J, Evans A, Liu Y, Honda M, Saavedra J, Aguilera G. Maternal deprivation in rats is associated with corticotrophin-releasing hormone (CRH) promoter hypomethylation and enhances CRH transcriptional responses to stress in adulthood. J Neuroendocrinol. 2012;24:1055-64 pubmed publisher
    ..and CRH promoter methylation in the hypothalamic paraventricular nucleus (PVN) and central nucleus of the amygdala (CeA)...
  27. Carvalho S, Troost E, Bons J, Menheere P, Lambin P, Oberije C. Prognostic value of blood-biomarkers related to hypoxia, inflammation, immune response and tumour load in non-small cell lung cancer - A survival model with external validation. Radiother Oncol. 2016;119:487-94 pubmed publisher
    ..inflammation [interleukin-6 (IL-6), IL-8, and C-reactive protein (CRP)], and tumour load [carcinoembryonic antigen (CEA), and cytokeratin fragment 21-1 (Cyfra 21-1)]...
  28. Rondon A, Ty N, Béquignat J, Quintana M, Briat A, Witkowski T, et al. Antibody PEGylation in bioorthogonal pretargeting with trans-cyclooctene/tetrazine cycloaddition: in vitro and in vivo evaluation in colorectal cancer models. Sci Rep. 2017;7:14918 pubmed publisher
    ..We used colorectal xenograft (HT29/Ts29.2) and peritoneal carcinomatosis (A431-CEA-Luc/35A7) as tumor cells/mAbs models and fluorescent tetrazines (TZ)...
  29. Gissen P, Johnson C, Morgan N, Stapelbroek J, Forshew T, Cooper W, et al. Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome. Nat Genet. 2004;36:400-4 pubmed
    ..VPS33B encodes a homolog of the class C yeast vacuolar protein sorting gene, Vps33, that contains a Sec1-like domain important in the regulation of vesicle-to-target SNARE complex formation and subsequent membrane fusion...
  30. Mulaudzi T, Robbs J. The influence of diabetes mellitus on early outcome following carotid endarterectomy. S Afr J Surg. 2015;53:9-12 pubmed
    ..are few studies that look at the influence of diabetes mellitus on early outcome following carotid endarterectomy (CEA)...
  31. Kafami M, Nasimi A. Contribution of amygdala to the pressor response elicited by microinjection of angiotensin II into the bed nucleus of the stria terminalis. Brain Res Bull. 2016;127:202-207 pubmed publisher
    ..responses elicited by microinjection of AngII into the BST, using blockade of the central nucleus of amygdala (CeA) and single unit recording from the CeA, while injecting AngII into the BST in anesthetized rat...
  32. Wen Z, Si A, Yang J, Yang P, Yang X, Liu H, et al. Elevation of CA19-9 and CEA is associated with a poor prognosis in patients with resectable gallbladder carcinoma. HPB (Oxford). 2017;19:951-956 pubmed publisher
    The aim of this study was to determine whether a combination of the tumour markers carcinoembryonic (CEA) and carbohydrate antigen 19-9 (CA19-9) would be helpful in predicting the prognosis of patients with gallbladder carcinoma (GBC) ..
  33. Dillon P, Petroni G, Smolkin M, Brenin D, Chianese Bullock K, Smith K, et al. A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer. J Immunother Cancer. 2017;5:92 pubmed publisher
    ..A vaccine consisting of 9 MHC class I-restricted breast cancer-associated peptides (from MAGE-A1, -A3, and -A10, CEA, NY-ESO-1, and HER2 proteins) was combined with a TLR3 agonist, poly-ICLC, along with a helper peptide derived from ..
  34. Ryu T, Takami Y, Wada Y, Tateishi M, Matsushima H, Yoshitomi M, et al. Oncological outcomes after hepatic resection and/or surgical microwave ablation for liver metastasis from gastric cancer. Asian J Surg. 2017;: pubmed publisher
    ..0%. OS did not significantly vary among the surgical procedures. In multivariable analysis, positive of both CEA and CA19-9 were independent predictors of poor survival (hazard ratio [HR] 4.51; P = 0...
  35. Litvin Y, Turner C, Ríos M, Maras P, Chaudhury S, Baker M, et al. Fibroblast growth factor 2 alters the oxytocin receptor in a developmental model of anxiety-like behavior in male rat pups. Horm Behav. 2016;86:64-70 pubmed publisher
    ..Comparable changes, though not as pronounced, were also found for the central amygdala (CeA)...
  36. Valenti G, Vitale S, Tropea A, Biondi A, Laganà A. Tumor markers of uterine cervical cancer: a new scenario to guide surgical practice?. Updates Surg. 2017;69:441-449 pubmed publisher
    ..Markers such as CEA, SCC-Ag, CD44, have been developed to detect invasive forms...
  37. Lareyre F, Nguyen E, Raffort J, Carboni J, Doyen J, Hassen Khodja R, et al. Changes in Ocular Subfoveal Choroidal Thickness After Carotid Endarterectomy Using Enhanced Depth Imaging Optical Coherence Tomography: A Pilot Study. Angiology. 2017;:3319717737223 pubmed publisher
    The influence of both severe chronic carotid stenosis and carotid endarterectomy (CEA) on ocular tissue has been poorly evaluated...
  38. Loosen S, Roderburg C, Kauertz K, Koch A, Vucur M, Schneider A, et al. CEA but not CA19-9 is an independent prognostic factor in patients undergoing resection of cholangiocarcinoma. Sci Rep. 2017;7:16975 pubmed publisher
    ..Of note, while CA19-9 and CEA were able to discriminate between CCA and healthy controls, CEA showed a higher accuracy for the differentiation ..
  39. Murthy S, John D, Godinho I, Godinho M, Guddattu V, Nair N. A protocol for a systematic review of economic evaluation studies conducted on neonatal systemic infections in South Asia. Syst Rev. 2017;6:252 pubmed publisher
    ..and Dissemination Library (CRD) Database, Popline, IndMed, MedKnow, IMSEAR, the Cost Effectiveness Analysis (CEA) Registry and Pediatric Economic Database Evaluation (PEDE)...
  40. Morales Oyarvide V, Guzmán Huerta E. [Macrocystic serous cystadenoma of the pancreas masquerading as a mucinous cystadenoma: case report]. Cir Cir. 2012;80:278-82 pubmed
    ..Fine-needle aspiration (FNA) of the cyst revealed mucoid contents and a carcinoembryonic antigen (CEA) level of 0.69 ng/mL...
  41. Dolscheid Pommerich R, Manekeller S, Walgenbach Brunagel G, Kalff J, Hartmann G, Wagner B, et al. Clinical Performance of CEA, CA19-9, CA15-3, CA125 and AFP in Gastrointestinal Cancer Using LOCI™-based Assays. Anticancer Res. 2017;37:353-359 pubmed
    ..Best performance was found for CEA in colorectal cancer (area under the curve=0.84, sensitivity=51.7% at 95% specificity vs...
  42. Hwang J, Song J, Kim J, Chung M, Kim D, Song J, et al. Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey. BMC Pulm Med. 2017;17:147 pubmed publisher
    ..7/39 [17.9%], P?=?0.008). Furthermore, current smokers had meaningfully higher DSS and serum CEA levels than non-current smokers (P?=?0.011 and P?=?0...
  43. Qiu Z, Shu J, Tang D. Near-Infrared-to-Ultraviolet Light-Mediated Photoelectrochemical Aptasensing Platform for Cancer Biomarker Based on Core-Shell NaYF4:Yb,Tm@TiO2 Upconversion Microrods. Anal Chem. 2017;: pubmed publisher
    ..photoelectrochemical (PEC) aptasensing platform for the sensitive detection of carcinoembryonic antigen (CEA) based on core-shell NaYF4:Yb,Tm@TiO2 upconversion microrods by coupling with target-triggered rolling circle ..
  44. Kojima A, Saga I, Ishikawa M. Intraoperative Hypoglossal Nerve Mapping During Carotid Endarterectomy: Technical Note. World Neurosurg. 2018;113:249-253 pubmed publisher
    Hypoglossal nerve deficit is a possible complication caused by carotid endarterectomy (CEA). The accidental injury of the hypoglossal nerve during surgery is one of the major reasons for permanent hypoglossal nerve palsy...
  45. Ming Z, Criswell H, Breese G. Evidence for TNFα action on excitatory and inhibitory neurotransmission in the central amygdala: a brain site influenced by stress. Brain Behav Immun. 2013;33:102-11 pubmed publisher
    ..Because cytokines microinjected into central-amygdala (CeA) substitute for stress in a behavioral paradigm, the possibility was raised that cytokines increased by stress ..
  46. Kawai T, Tominaga S, Hiroi S, Ogata S, Nakanishi K, Kawahara K, et al. Peritoneal malignant mesothelioma (PMM), and primary peritoneal serous carcinoma (PPSC) and reactive mesothelial hyperplasia (RMH) of the peritoneum. Immunohistochemical and fluorescence in situ hybridisation (FISH) analyses. J Clin Pathol. 2016;69:706-12 pubmed publisher
    ..2, D2-40, WT-1, HBME1, thrombomodulin), adenocarcinoma-associated markers (CEA, BerEP4, MOC31, ER (estrogen receptor), PgR, TTF-1, Claudin-4, Pax8), and malignant-related and benign-related ..
  47. Suzuki T, Shimada H, Ushigome M, Koike J, Funahashi K, Nemoto T, et al. Three-year monitoring of serum p53 antibody during chemotherapy and surgery for stage IV rectal cancer. Clin J Gastroenterol. 2016;9:55-8 pubmed publisher
    ..Screening tests for CEA (29.4 ng/ml), CA19-9 (41.1 U/ml), and serum p53 antibody (2170 U/ml) were positive before treatment...
  48. Zhang B, Ding C. Displacement-type amperometric immunosensing platform for sensitive determination of tumour markers. Biosens Bioelectron. 2016;82:112-8 pubmed publisher
    The sensitive determination of carcino embryonie antigen (CEA)-a set of highly related glycoproteins involved in cell adhesion-is beneficial to the early diagnosis of colorectal cancer...
  49. Okamura K, Takayama K, Izumi M, Harada T, Furuyama K, Nakanishi Y. Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer. Lung Cancer. 2013;80:45-9 pubmed publisher
    ..The serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragments (CYFRA 21-1) were retrospectively analyzed in 655 lung cancer patients and 237 ..
  50. Jia J, Zheng X, Chen Y, Wang L, Lin L, Ye X, et al. Stage-dependent changes of preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in colorectal cancer. Tumour Biol. 2015;36:9319-25 pubmed publisher
    ..Preoperative whole blood counts, serum levels of carcinoembryonic antigen (CEA), and clinicopathologic data were collected...
  51. Andrade Franzé G, Andrade C, Gasparini S, De Luca L, De Paula P, Colombari D, et al. Importance of the central nucleus of the amygdala on sodium intake caused by deactivation of lateral parabrachial nucleus. Brain Res. 2015;1625:238-45 pubmed publisher
    The lateral parabrachial nucleus (LPBN) and the central nucleus of the amygdala (CeA) are important central areas for the control of sodium appetite...
  52. Kishiki T, Masaki T, Mastuoka H, Abe N, Mori T, Sugiyama M. New Prognostic Scoring System for Incurable Stage IV Colorectal Cancer. Asian Pac J Cancer Prev. 2016;17:597-601 pubmed
    ..Univariate analysis revealed significant associations between CSS and WBC, albumin, CRP, CEA values, mGPS, PNI, and PI values among preoperative factors...
  53. Kunizaki M, Fukuda A, Wakata K, Tominaga T, Nonaka T, Miyazaki T, et al. Clinical Significance of Serum p53 Antibody in the Early Detection and Poor Prognosis of Gastric Cancer. Anticancer Res. 2017;37:1979-1984 pubmed
    ..The positive rates for S-p53Ab, carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) of patients with stage I GC were 10.3% (13/126), 2.4% (3/126), and 8.7% (11/126), respectively...
  54. Muley T, Fetz T, Dienemann H, Hoffmann H, Herth F, Meister M, et al. Tumor volume and tumor marker index based on CYFRA 21-1 and CEA are strong prognostic factors in operated early stage NSCLC. Lung Cancer. 2008;60:408-15 pubmed
    ..V(path) was calculated as an ellipsoid body. TMI represents the geometric mean of normalized CYFRA 21-1 and CEA values. Patients with a V(path)< or =13...
  55. Bonsor D, Beckett D, Sundberg E. Structure of the N-terminal dimerization domain of CEACAM7. Acta Crystallogr F Struct Biol Commun. 2015;71:1169-75 pubmed publisher
    ..47 Å resolution. The overall fold of CEACAM7 is similar to those of CEACAM1 and CEACAM5; however, there are differences, the most notable of which is an insertion that causes the C'' strand to buckle, ..
  56. Delaney A, Crane J. Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep. 2016;6:19255 pubmed publisher
    ..carried by neurons of the pontine parabrachial nucleus to neurons of the lateral division of the central amydala (CeA-L) is thought to contribute to the affective components of pain and is required for the formation of conditioned-..
  57. Chen J, Gao H, Wang Q, Li Q. Expression and clinical significance of tumor markers in ovarian mature cystic teratoma. Clin Exp Obstet Gynecol. 2016;43:397-400 pubmed
    CA19-9, CA125, AFP, CEA, and CA153 are common cancer biomarkers. This study aimed to detect the expression and assess clinical significance of these biomarkers in ovarian mature cystic teratomas (OMCT)...
  58. Santangelo G, Mix D, Ghazi A, Stoner M, Vates G, Stone J. Development of a Whole-Task Simulator for Carotid Endarterectomy. Oper Neurosurg (Hagerstown). 2017;: pubmed publisher
    Surgical education relies on operative exposure with live patients. Carotid endarterectomy (CEA) demands an experienced surgeon with a very low complication rate...
  59. Verma D, Wood J, Lach G, Mietzsch M, Weger S, Heilbronn R, et al. NPY Y2 receptors in the central amygdala reduce cued but not contextual fear. Neuropharmacology. 2015;99:665-74 pubmed publisher
    ..Recently, also the central nucleus of the amygdala (CEA) has emerged as a site of plasticity actively controlling efferent connections to downstream effector brain areas...
  60. Farkas G, Cvetanovich G, Rajan K, Espinoza Orías A, Nho S. Impact of Femoroacetabular Impingement Morphology on Gait Assessment in Symptomatic Patients. Sports Health. 2015;7:429-36 pubmed publisher
    ..The alpha angle (AA) and center-edge angle (CEA) were measured on anteroposterior (AP) pelvis, Dunn lateral, and false-profile radiographs, and inter- and ..
  61. Bajo M, Montgomery S, Cates L, Nadav T, Delucchi A, Cheng K, et al. Evaluation of TLR4 Inhibitor, T5342126, in Modulation of Ethanol-Drinking Behavior in Alcohol-Dependent Mice. Alcohol Alcohol. 2016;51:541-8 pubmed publisher
    ..calcium-binding adapter molecule 1), a microglial activation marker, in the central nucleus of the amygdala (CeA) and dentate gyrus (DG) of the hippocampus...
  62. Barkat M, Hajibandeh S, Torella F, Antoniou G. Systematic Review and Meta-analysis of Dual Versus Single Antiplatelet Therapy in Carotid Interventions. Eur J Vasc Endovasc Surg. 2017;53:53-67 pubmed publisher
    ..review and perform a meta-analysis to assess the effects of dual antiplatelet therapy in carotid endarterectomy (CEA) and stenting (CAS)...
  63. Lima F, Yen T, Butler J, Yang J, Xu J, Gruberg L. Impact of chronic kidney disease in patients undergoing percutaneous or surgical carotid artery revascularization: Insights of the healthcare cost and utilization Project's National Inpatient Sample. Cardiovasc Revasc Med. 2016;17:560-565 pubmed publisher
    Carotid artery stenting (CAS) and carotid artery endarterectomy (CEA) are complementary techniques for management of patients with carotid artery stenosis...
  64. Thistlethwaite F, Gilham D, Guest R, Rothwell D, Pillai M, Burt D, et al. The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity. Cancer Immunol Immunother. 2017;66:1425-1436 pubmed publisher
    ..was to determine the feasibility of delivering first-generation CAR T cell therapy to patients with advanced, CEACAM5+ malignancy...
  65. Kunizaki M, Hamasaki K, Wakata K, Tobinaga S, Sumida Y, Hidaka S, et al. Clinical Value of Serum p53 Antibody in the Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma. Anticancer Res. 2018;38:1807-1813 pubmed
    ..Serum p53 antibody (S-p53Ab), squamous cell carcinoma antigen (SCC-Ag), and carcinoembryonic antigen (CEA) were investigated to evaluate the significance of single and combined tumor markers in determining the diagnosis ..
  66. Hatakeyama K, Wakabayashi Nakao K, Ohshima K, Sakura N, Yamaguchi K, Mochizuki T. Novel protein isoforms of carcinoembryonic antigen are secreted from pancreatic, gastric and colorectal cancer cells. BMC Res Notes. 2013;6:381 pubmed publisher
    Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is an oncofetal cell surface glycoprotein. Because of its high expression in cancer cells and secretion into serum, CEA has been widely used as a serum tumor marker...
  67. Zou Y, Lin X, Fan D, Chen X, Yang Z, Zheng X, et al. [Expression and clinical significance of G protein-coupled receptor 31 in colorectal cancer tissue]. Zhonghua Wei Chang Wai Ke Za Zhi. 2015;18:935-40 pubmed
    ..7% in high expression group (all P<0.05). Multivariate analysis revealed elderly, abnormal CEA, lymphatic metastasis, distant metastasis and up-regulated GPR31 expression were independent risk factors of ..
  68. Antonilli M, Rahimi H, Visconti V, Napoletano C, Ruscito I, Zizzari I, et al. Triple peptide vaccination as consolidation treatment in women affected by ovarian and breast cancer: Clinical and immunological data of a phase I/II clinical trial. Int J Oncol. 2016;48:1369-78 pubmed publisher
    ..BC) patients after completion of standard therapies were vaccinated with MUC1, ErbB2 and carcinoembryonic antigen (CEA) HLA-A2+-restricted peptides and Montanide...
  69. Shi Q, Tian C, Huang X, Pu C. Analysis of Cerebrospinal Fluid and Serum CEA Concentration in Non-neoplastic Diseases. Ann Clin Lab Sci. 2016;46:180-3 pubmed
    Carcinoembryonic antigen (CEA) in cerebrospinal fluid (CSF) is important for the diagnosis of meningeal carcinomatosis. Its relationship with CSF and serum in non-neoplastic diseases may be beneficial for earlier diagnosis and treatment...
  70. Letelier P, Riquelme I, Hernández A, Guzmán N, Farias J, Roa J. Circulating MicroRNAs as Biomarkers in Biliary Tract Cancers. Int J Mol Sci. 2016;17: pubmed publisher
    ..due to brush cytology havinga low sensitivity and the standard markers, such as carcinoembryonic antigen (CEA) and carbohydrate 19-9 (CA19-9), not having enough sensitivity nor specificity to be used in a differential ..
  71. Zhang H, Zhang B, Gao L, Zhang L, Zhu K, Cheng R, et al. Clinical significance of cripto-1 expression in lung adenocarcinoma. Oncotarget. 2017;8:79087-79098 pubmed publisher
    ..The combination of cripto-1 expression and serum CEA level was correlated with both PFS and OS...
  72. Yi Y, Li B, Wang Z, Sun H, Gong H, Zhang Z. CYFRA21-1 and CEA are useful markers for predicting the sensitivity to chemoradiotherapy of esophageal squamous cell carcinoma. Biomarkers. 2009;14:480-5 pubmed publisher
    ..The cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) and carcinoembryonic antigen (CEA) levels were measured before CRT by enzyme-linked immunosorbent assays in patients with primary ESCCs using 3...
  73. Kimmell K, Lasota E, Weil R, Marko N. Comparative Effectiveness Analysis of Treatment Options for Single Brain Metastasis. World Neurosurg. 2015;84:1316-32 pubmed publisher
    ..We performed a comparative effectiveness analysis (CEA) that integrated efficacy, cost, and quality of life (QoL) data for alternate BM treatments...
  74. Kim H, Lee G, Choi K, Kim D, Ryu J, Hwang K, et al. SRSF5: a novel marker for small-cell lung cancer and pleural metastatic cancer. Lung Cancer. 2016;99:57-65 pubmed publisher
    ..the highest detection accuracy (89%) for total LC, and it was superior to that (74%) of carcinoembryonic antigen [CEA, a commonly used non-SCLC (NSCLC) marker]...
  75. Paraskevas K, Loftus I. Safety of carotid revascularization within 48 hours of symptomatic presentation. J Cardiovasc Surg (Torino). 2017;58:139-142 pubmed publisher
    ..been a gradual shift in the recommendations of carotid guidelines towards performance of carotid endarterectomy (CEA) earlier in patients with >70% carotid artery stenosis suffering an ipsilateral transient ischemic attack (TIA)/..
  76. Shintani T, Matsuo Y, Iizuka Y, Mitsuyoshi T, Mizowaki T, Hiraoka M. Prognostic Significance of Serum CEA for Non-small Cell Lung Cancer Patients Receiving Stereotactic Body Radiotherapy. Anticancer Res. 2017;37:5161-5167 pubmed
    To examine the prognostic significance of serum carcinoembryonic antigen (CEA) for stage I non-small cell lung cancer (NSCLC) treated with stereotactic body radiotherapy (SBRT)...
  77. Stern N, Markel G, Arnon T, Gruda R, Wong H, Gray Owen S, et al. Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J Immunol. 2005;174:6692-701 pubmed
    ..existence of a novel inhibitory mechanism of NK cell cytotoxicity mediated by the homophilic carcinoembryonic Ag (CEA)-related cell adhesion molecule 1 (CEACAM1) interactions...
  78. Ikeda S, Yoshimura K, Onda T, Kasamatsu T, Kato T, Ishikawa M, et al. Combination of squamous cell carcinoma-antigen, carcinoembryonic antigen, and carbohydrate antigen 19-9 predicts positive pelvic lymph nodes and parametrial involvement in early stage squamous cell carcinoma of the uterine cervix. J Obstet Gynaecol Res. 2012;38:1260-5 pubmed publisher
    ..the pretreatment values of four tumor markers (squamous cell carcinoma [SCC]-antigen, carcinoembryonic antigen [CEA], carbohydrate antigen [CA]19-9, and CA125) and postsurgical high-risk factors (parametrial involvement and ..
  79. Stiksma J, Grootendorst D, van der Linden P. CA 19-9 as a marker in addition to CEA to monitor colorectal cancer. Clin Colorectal Cancer. 2014;13:239-44 pubmed publisher
    ..CA 19-9 levels can be used to monitor the disease process in patients with colorectal cancer who had no elevated CEA levels...
  80. Cannady R, Fisher K, Graham C, Crayle J, Besheer J, Hodge C. Potentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self-administration in a CaMKII-dependent manner. Addict Biol. 2017;22:652-664 pubmed publisher
    ..increases phosphorylation (activation) of AMPAR subtype GluA1 S831 (pGluA1 S831) in the central amygdala (CeA), basolateral amygdala and nucleus accumbens core (AcbC) of selectively bred alcohol-preferring P-rats as compared ..
  81. Li N, Jia L, Ma R, Jia W, Lü Y, Shi S, et al. A novel sandwiched electrochemiluminescence immunosensor for the detection of carcinoembryonic antigen based on carbon quantum dots and signal amplification. Biosens Bioelectron. 2017;89:453-460 pubmed publisher
    ..a novel sandwiched electrochemiluminescence (ECL) immunosensor for the detection of carcinoembryonic antigen (CEA) was developed...
  82. Iemolo A, Seiglie M, Blasio A, Cottone P, Sabino V. Pituitary adenylate cyclase-activating polypeptide (PACAP) in the central nucleus of the amygdala induces anxiety via melanocortin receptors. Psychopharmacology (Berl). 2016;233:3269-77 pubmed publisher
    ..polypeptide (PACAP) and its receptor PAC1 (PAC1R) are highly expressed in the central nucleus of the amygdala (CeA), and they have gained growing attention for their proposed role in mediating the body's response to stress...
  83. Ivry S, Sharib J, Dominguez D, Roy N, Hatcher S, Yip Schneider M, et al. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. Clin Cancer Res. 2017;23:4865-4874 pubmed publisher
    ..Gastricsin significantly outperformed the most widely used molecular biomarker, carcinoembryonic antigen (CEA), which demonstrated 94% specificity and 65% sensitivity...
  84. Wang Y, Ren G, Zhang T, Zou S, Mao C, Wang X. Effect of magnetite powder on anaerobic co-digestion of pig manure and wheat straw. Waste Manag. 2017;66:46-52 pubmed publisher
    ..The variations in pH, alkalinity, cellulase activity (CEA), dehydrogenase activity (DHA) and methane production, were analyzed by phases...
  85. Gao Y, Song P, Li H, Jia H, Zhang B. Elevated serum CEA levels are associated with the explosive progression of lung adenocarcinoma harboring EGFR mutations. BMC Cancer. 2017;17:484 pubmed publisher
    Serum carcinoembryonic antigen (CEA) levels are a predictor of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) efficacy and are associated with epidermal growth factor receptor (EGFR) gene mutations...
  86. Wang F, Lu J, Li S, Huo X, Liu X, Du X, et al. Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis. Anticancer Res. 2017;37:4515-4522 pubmed
    ..The value of current serum biomarkers (Pro-GRP, NSE, CYFRA21-1 and CEA) was obtained from a clinical laboratory...
  87. Balan I, Warnock K, Puche A, GONDRE LEWIS M, Aurelian L. Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity. Brain Behav Immun. 2018;69:139-153 pubmed publisher
    ..We have previously shown that a neuronal Toll-like receptor 4 (TLR4) signal located in the central amygdala (CeA) and ventral tegmental area (VTA) controls the initiation of binge drinking in alcohol-preferring P rats, and TLR4 ..
  88. Vegh I, Sotelo T, Estenoz J, Fontanellas A, Navarro S, Millan I, et al. Tumor cytosol carcinoembryonic antigen as prognostic parameter in non-small cell lung cancer. Tumori. 2002;88:142-6 pubmed
    Carcinoembryonic antigen (CEA) belongs to a family of cell surface glycoproteins. Its level in serum has a significant value for the follow-up and treatment of patients with malignancies...
  89. Mortezai N, Harder S, Schnabel C, Moors E, Gauly M, Schluter H, et al. Tandem affinity depletion: a combination of affinity fractionation and immunoaffinity depletion allows the detection of low-abundance components in the complex proteomes of body fluids. J Proteome Res. 2010;9:6126-34 pubmed publisher
    ..In this way, we selectively enriched the glycoprotein, CEA, a known cancer marker which had been spiked into normal plasma...
  90. Nonaka M, Ma B, Imaeda H, Kawabe K, Kawasaki N, Hodohara K, et al. Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) recognizes a novel ligand, Mac-2-binding protein, characteristically expressed on human colorectal carcinomas. J Biol Chem. 2011;286:22403-13 pubmed publisher
    ..Recently, we have reported that DC-SIGN interacts with carcinoembryonic antigen (CEA) expressed on colorectal carcinoma cells...
  91. Hsieh T, Huang W, Lai C, Tsao S, Su C. Diagnostic value of tumor markers in lung adenocarcinoma-associated cytologically negative pleural effusions. Cancer Cytopathol. 2013;121:483-8 pubmed publisher
    ..sensitivity and optimal cutoff points for the tumor markers HER2/neu, CYFRA 21-1, and carcinoembryonic antigen (CEA) to distinguish LAC-CNPEs from benign PEs...
  92. Kim J, Kim J, Rho T, Lee J. Rapid chemiluminescent sandwich enzyme immunoassay capable of consecutively quantifying multiple tumor markers in a sample. Talanta. 2014;129:106-12 pubmed publisher
    ..quantify trace levels of triple tumor markers, such as alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), and prostate specific antigen (PSA) in a sample...