CDS2

Summary

Gene Symbol: CDS2
Description: CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Alias: CDP-DAG synthase 2, CDP-DG synthase 2, CDP-DG synthetase 2, CDP-diacylglycerol synthase 2, CDP-diglyceride diphosphorylase 2, CDP-diglyceride pyrophosphorylase 2, CDP-diglyceride synthase 2, CDP-diglyceride synthetase 2, CDS 2, CTP:phosphatidate cytidylyltransferase 2, phosphatidate cytidylyltransferase 2
Species: human

Top Publications

  1. doi Extraplastidial cytidinediphosphate diacylglycerol synthase activity is required for vegetative development in Arabidopsis thaliana
    Yonghong Zhou
    Unit of Botany, Institute for Biology I, RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany
    Plant J 75:867-79. 2013
  2. pmc MMAPPR: mutation mapping analysis pipeline for pooled RNA-seq
    Jonathon T Hill
    Department of Neurobiology and Anatomy, University of Utah Molecular Medicine Program, University of Utah, Salt Lake City, Utah 84112, USA
    Genome Res 23:687-97. 2013
  3. pmc CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis
    Weijun Pan
    Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 120:489-98. 2012
  4. ncbi Differential expression of cold- and diet-specific genes encoding two carp liver delta 9-acyl-CoA desaturase isoforms
    S D Polley
    School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 284:R41-50. 2003
  5. pmc Abscisic acid has a key role in modulating diverse plant-pathogen interactions
    Jun Fan
    Department of Disease and Stress Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom
    Plant Physiol 150:1750-61. 2009
  6. pmc Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control
    Ching Hao Li
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Neoplasia 12:150-60. 2010
  7. pmc Two closely related genes of Arabidopsis encode plastidial cytidinediphosphate diacylglycerol synthases essential for photoautotrophic growth
    André Haselier
    Unit of Botany, Institute for Biology I, Rheinisch Westfälische Technische Hochschule Aachen University, 52056 Aachen, Germany
    Plant Physiol 153:1372-84. 2010
  8. doi Rapid decrease in active tension generated by C2C12 myotubes after termination of artificial exercise
    Hideaki Fujita
    Toyota Central R and D Labs Incorporation, Yokomichi, Nagakute, Aichi, 480 1192, Japan
    J Muscle Res Cell Motil 31:279-88. 2010
  9. doi Underexpression of miR-224 in methotrexate resistant human colon cancer cells
    Núria Mencia
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E 08028 Barcelona, Spain
    Biochem Pharmacol 82:1572-82. 2011
  10. doi Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells
    Xu Bao Shi
    Department of Urology, University of California, Davis, School of Medicine, Sacramento, California 95817, USA
    Prostate 68:1816-26. 2008

Research Grants

Scientific Experts

  • Machiko Ikegami
  • Anna Mercadé
  • Zongbing You
  • Yonghong Zhou
  • Jonathon T Hill
  • Weijun Pan
  • Werner Baumgartner
  • Agnes Weth
  • Margrit Frentzen
  • Núria Mencia
  • André Haselier
  • Hideaki Fujita
  • Ching Hao Li
  • Stephanie Halford
  • Jun Fan
  • Xu Bao Shi
  • Anna Brotcke
  • Suzanne L Inglis-Broadgate
  • David M Hunt
  • S D Polley
  • Helga Peisker
  • Bushra Gorsi
  • H Joseph Yost
  • Brent W Bisgrove
  • Peter Dormann
  • Bradley L Demarest
  • Yi Chu Su
  • George E Davis
  • Constantinos M Mikelis
  • Jesus Torres-Vazquez
  • Amber N Stratman
  • Brant M Weinstein
  • Kenna M Shaw
  • Kameha R Kidd
  • Makoto Kamei
  • J Silvio Gutkind
  • Van N Pham
  • Daniel Castranova
  • Brigid D Lo
  • Elisabet Selga
  • Veronique Noe
  • Carlos J Ciudad
  • Kazunori Shimizu
  • Minoru Hirano
  • Hana Akbari
  • Jaw Jou Kang
  • Eiji Nagamori
  • Po Ling Liao
  • Yu Wen Cheng
  • Chris Lamb
  • Casey Crooks
  • Peter Doerner
  • Lionel Hill
  • Lingru Xue
  • Hongwu Chen
  • M Volta
  • June X Zou
  • Regina Gandour-Edwards
  • Ralph W deVere White
  • S Halford
  • Charles C Kim
  • Emilio Garcia
  • Denise M Monack
  • Patrick Chain
  • David S Weiss
  • Stephanie Malfatti
  • Michelle Gaasenbeek
  • Michael E Cheetham
  • Ruby Banerjee
  • Brian J Clark
  • Louise Ocaka
  • J Paul Chapple
  • A Lykidis
  • R T Trueman
  • P E Tiku
  • A R Cossins
  • I Y Morozov
  • M X Caddick
  • Neil D Ebenezer
  • Moin Mohamed
  • Rhian Gwilliam
  • Suzanne Inglis
  • Pauline Spencer
  • A Ballabio
  • G G Consalez
  • S Banfi
  • M Mariani
  • O Zuffardi
  • C Gattuso
  • E Rossi

Detail Information

Publications19

  1. doi Extraplastidial cytidinediphosphate diacylglycerol synthase activity is required for vegetative development in Arabidopsis thaliana
    Yonghong Zhou
    Unit of Botany, Institute for Biology I, RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany
    Plant J 75:867-79. 2013
    ..Here we have focused on the extraplastidial CDS isoforms, encoded by CDS1 and CDS2 which are constitutively expressed contrary to CDS3...
  2. pmc MMAPPR: mutation mapping analysis pipeline for pooled RNA-seq
    Jonathon T Hill
    Department of Neurobiology and Anatomy, University of Utah Molecular Medicine Program, University of Utah, Salt Lake City, Utah 84112, USA
    Genome Res 23:687-97. 2013
    ..5 and tbx1, and used it to map two novel ENU-induced cardiovascular mutants, with mutations found in the ctr9 and cds2 genes...
  3. pmc CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis
    Weijun Pan
    Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 120:489-98. 2012
    ..Loss of CDS2, 1 of 2 vertebrate CDS enzymes, results in vascular-specific defects in zebrafish in vivo and failure of VEGFA-..
  4. ncbi Differential expression of cold- and diet-specific genes encoding two carp liver delta 9-acyl-CoA desaturase isoforms
    S D Polley
    School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 284:R41-50. 2003
    ..Here we report the cloning and characterization of Cds2, a second Delta9-acyl CoA-desaturase expressed in carp liver...
  5. pmc Abscisic acid has a key role in modulating diverse plant-pathogen interactions
    Jun Fan
    Department of Disease and Stress Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom
    Plant Physiol 150:1750-61. 2009
    We isolated an activation-tagged Arabidopsis (Arabidopsis thaliana) line, constitutive disease susceptibility2-1D (cds2-1D), that showed enhanced bacterial growth when challenged with various Pseudomonas syringae strains...
  6. pmc Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control
    Ching Hao Li
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Neoplasia 12:150-60. 2010
    ..However, in the high-dose MMC treatment, only the p53 translocated to the mitochondria and resulted in apoptosis progression. On the basis of this study, we thought mitochondrial p53 might regulate apoptosis in a biphasic manner...
  7. pmc Two closely related genes of Arabidopsis encode plastidial cytidinediphosphate diacylglycerol synthases essential for photoautotrophic growth
    André Haselier
    Unit of Botany, Institute for Biology I, Rheinisch Westfälische Technische Hochschule Aachen University, 52056 Aachen, Germany
    Plant Physiol 153:1372-84. 2010
    ..Alternative translation initiation or alternative splicing of CDS2 and CDS4 transcripts can result in up to 10 isoforms...
  8. doi Rapid decrease in active tension generated by C2C12 myotubes after termination of artificial exercise
    Hideaki Fujita
    Toyota Central R and D Labs Incorporation, Yokomichi, Nagakute, Aichi, 480 1192, Japan
    J Muscle Res Cell Motil 31:279-88. 2010
    ..RT-PCR revealed that the expression of several genes associated with atrophy, namely Smc6, Vegfa, Jarid2, Kitl, Cds2, Inmt, Fasn, Neurl, Topors, and Cul2, were also changed after termination of artificial exercise...
  9. doi Underexpression of miR-224 in methotrexate resistant human colon cancer cells
    Núria Mencia
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E 08028 Barcelona, Spain
    Biochem Pharmacol 82:1572-82. 2011
    ..Among them CDS2, DCP2, HSPC159, MYST3 and SLC4A4 were validated at the mRNA level by qRT-PCR...
  10. doi Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells
    Xu Bao Shi
    Department of Urology, University of California, Davis, School of Medicine, Sacramento, California 95817, USA
    Prostate 68:1816-26. 2008
    ..It is unclear how the aberrantly activated AR loads onto regulatory regions of AR-targeted genes. The purpose of this study was to assess the AR chromatin loading in an androgen-depleted environment...
  11. doi STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury
    Machiko Ikegami
    Cincinnati Children s Hospital, Div of Pulmonary Biology, Cincinnati, OH 45229 3039, USA
    J Appl Physiol (1985) 104:1753-60. 2008
    ..expressed in type II cells that may influence surfactant phospholipid synthesis (Glut-1, Slc34a2, Gpam, Acox2, and Cds2). Stat-3(Delta/Delta) mice were more susceptible to intratracheal lipopolysaccharide (LPS)...
  12. ncbi Characterization and physical mapping of the porcine CDS1 and CDS2 genes
    A Mercade
    Departament de Ciencia Animal i dels Aliments, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Anim Biotechnol 18:23-35. 2007
    ..Moreover, a 1240-bp fragment of the pig CDS2 mRNA was amplified and sequenced...
  13. pmc Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis
    Anna Brotcke
    Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Fairchild Bldg D041, Stanford, CA 94305, USA
    Infect Immun 74:6642-55. 2006
    ..Mutations in MglA-regulated genes within the FPI (pdpB and cds2) as well as outside the FPI (FTT0989, oppB, and FTT1209c) were either attenuated or hypervirulent in macrophages ..
  14. ncbi Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer
    Zongbing You
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    Cancer Res 66:175-83. 2006
    ..at significantly higher levels in several androgen-independent prostate cancer cell lines (PC3, DU145, cds1, cds2, and cds3) and tumors compared with the androgen-dependent cell lines (LNCaP and MLC-SV40) and tumors...
  15. ncbi Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2
    Suzanne L Inglis-Broadgate
    Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Gene 356:19-31. 2005
    ..We report here the isolation and characterization of two murine genes encoding this enzyme, Cds1 and Cds2. The genes encode proteins that are 73% identical and 92% similar but exhibit very different expression patterns...
  16. ncbi Genomic organization of human CDS2 and evaluation as a candidate gene for corneal hereditary endothelial dystrophy 2 on chromosome 20p13
    Stephanie Halford
    Exp Eye Res 75:619-23. 2002
  17. ncbi Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene
    M Volta
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Milan, Italy
    Genomics 55:68-77. 1999
    ..Using a bioinformatic approach, we have identified two novel transcripts (CDS1 and CDS2) highly homologous to the Drosophila CDS gene...
  18. ncbi Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes
    S Halford
    Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK
    Genomics 54:140-4. 1998
    ..using Drosophila phototransduction genes as a model system, two human CDP-diacylglycerol synthase genes (CDS1 and CDS2) were cloned and sequenced...
  19. ncbi The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content
    A Lykidis
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 272:33402-9. 1997
    ..with the presence of the two mRNAs, a cDNA predicted to encode a second human CDP-diacylglycerol synthetase (cds2) was also uncovered in the EST data base. In contrast to the two cds mRNAs, a single, 2...

Research Grants10

  1. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  2. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2002
    ..The goal is to understand the role of SP-D in the cellular and/or structural mechanisms involved in independent regulation of phospholipid and surfactant protein homeostasis. ..
  3. Role of C/EBPalpha in Cytoprotection and Recovery from Lung Injury
    Machiko Ikegami; Fiscal Year: 2010
    ..Furthermore, the molecular mechanisms, in particular the signaling pathways regulating Cebpa, of recombinant human FGF-7 treatment for acute lung injury will be determined. ..