CDR1

Summary

Gene Symbol: CDR1
Description: cerebellar degeneration-related protein 1, 34kDa
Alias: CDR, CDR34, CDR62A, cerebellar degeneration-related antigen 1
Species: human

Top Publications

  1. ncbi An investigation into the acute nootropic effects of Hypericum perforatum L. (St. John's Wort) in healthy human volunteers
    K A Ellis
    Neuropharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Hawthorn, Victoria, Australia
    Behav Pharmacol 12:173-82. 2001
  2. ncbi Dementia and work load evaluation of the elderly
    H A Nygaard
    Fyllingsdalen Sykehjem, Bergen, Norway
    Compr Gerontol A 1:65-8. 1987
  3. pmc Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 40:2300-5. 1996
  4. ncbi Analysis of immunoglobulin H gene rearrangement by polymerase chain reaction in primary central nervous system lymphoma
    Johan M Kros
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurosurg 97:1390-6. 2002
  5. doi Characteristics of disc hemorrhage in primary angle-closure glaucoma
    Yu Wen Lan
    Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan
    Ophthalmology 115:1328-33, 1333.e1. 2008
  6. ncbi Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake
    Elaine M Leslie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 69:629-39. 2006
  7. ncbi The Cohen diabetic (non-insulin-dependent) hypertensive rat model. Description of the model and pathologic findings
    A M Cohen
    Department of Medicine, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Am J Hypertens 6:989-95. 1993
  8. doi PAP1 [poly(A) polymerase 1] homozygosity and hyperadenylation are major determinants of increased mRNA stability of CDR1 in azole-resistant clinical isolates of Candida albicans
    Raman Manoharlal
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Microbiology 156:313-26. 2010
  9. pmc A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans
    Alix Coste
    Institute of Microbiology, University Hospital Lausanne, Switzerland
    Genetics 172:2139-56. 2006
  10. ncbi Diagnostic strategy using a modified clinical decision rule and D-dimer test to rule out pulmonary embolism in elderly in- and outpatients
    Maaike Sohne
    Academic Medical Center, Department of Vascular Medicine, Room F4 136, Meibergdreef 9, 1105 AZ Amsterdam
    Thromb Haemost 94:206-10. 2005

Research Grants

  1. DELIRIUM IN PERSONS WITH DEMENTIA
    Donna Fick; Fiscal Year: 2007
  2. AAC Rehabilitation for Conversation in Dementia
    Melanie Fried Oken; Fiscal Year: 2006
  3. MOLECULAR ANALYSIS OF CD8-MHC CLASS I INTERACTION
    Paula Kavathas; Fiscal Year: 1993
  4. Role of IG CDR-H3 in Responses to HIV Vaccines
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2010
  5. MURINE MODELS OF GENERALIZED AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 1990
  6. SELECTION OF T CELL RECEPTOR V-ALPHA REGIONS
    NICHOLAS GASCOIGNE; Fiscal Year: 2001
  7. The role of T cell repertoire selection in the NOD mouse model of MOG-induced EAE
    Anthony Quinn; Fiscal Year: 2007
  8. Cocaine degradation: Improving antibody efficacy
    KATHLEEN MCKENZIE; Fiscal Year: 2006
  9. EVOLUTION OF ADAPTIVE IMMUNITY
    Martin Flajnik; Fiscal Year: 1999
  10. Conformationally-Constrained PA Anthrax Vaccine
    Maurizio Zanetti; Fiscal Year: 2005

Detail Information

Publications142 found, 100 shown here

  1. ncbi An investigation into the acute nootropic effects of Hypericum perforatum L. (St. John's Wort) in healthy human volunteers
    K A Ellis
    Neuropharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Hawthorn, Victoria, Australia
    Behav Pharmacol 12:173-82. 2001
    ..Twelve healthy young subjects completed the Cognitive Drug Research (CDR) memory battery, following administration of placebo, 900 mg and 1800 mg hypericum (Blackmore's Hyperiforte)...
  2. ncbi Dementia and work load evaluation of the elderly
    H A Nygaard
    Fyllingsdalen Sykehjem, Bergen, Norway
    Compr Gerontol A 1:65-8. 1987
    ..Mental status was estimated by means of the Clinical Dementia Rating scale (CDR), and work load by means of a traditional work load scale...
  3. pmc Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 40:2300-5. 1996
    ..albicans ABC (ATP-binding cassette) transporter gene called CDR1 and of a gene conferring benomyl resistance (BENr), the product of which belongs to the class of major facilitator ..
  4. ncbi Analysis of immunoglobulin H gene rearrangement by polymerase chain reaction in primary central nervous system lymphoma
    Johan M Kros
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurosurg 97:1390-6. 2002
    ..genes by polymerase chain reaction (PCR) to the framework region (FR)3 and FR2 complementarity determining region (CDR)-III and CDR-II of these genes...
  5. doi Characteristics of disc hemorrhage in primary angle-closure glaucoma
    Yu Wen Lan
    Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan
    Ophthalmology 115:1328-33, 1333.e1. 2008
    ..To analyze the characteristics of disc hemorrhage in primary angle-closure glaucoma (PACG)...
  6. ncbi Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake
    Elaine M Leslie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 69:629-39. 2006
    ..The CdR1-rev cell line was found to have a Cd(2+) uptake and sensitivity level in between that of the CdR1 and MT(-/-) cell ..
  7. ncbi The Cohen diabetic (non-insulin-dependent) hypertensive rat model. Description of the model and pathologic findings
    A M Cohen
    Department of Medicine, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Am J Hypertens 6:989-95. 1993
    ..here a genetic type II diabetic hypertensive model (CDHM) developed by cross breeding the Cohen diabetic rat (CDR) and the SHR...
  8. doi PAP1 [poly(A) polymerase 1] homozygosity and hyperadenylation are major determinants of increased mRNA stability of CDR1 in azole-resistant clinical isolates of Candida albicans
    Raman Manoharlal
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Microbiology 156:313-26. 2010
    ..AS) and azole-resistant (AR) clinical isolates of Candida albicans, we recently demonstrated that CDR1 overexpression in AR isolates is due to its enhanced transcriptional activation and mRNA stability...
  9. pmc A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans
    Alix Coste
    Institute of Microbiology, University Hospital Lausanne, Switzerland
    Genetics 172:2139-56. 2006
    ..situated near the mating-type locus on chromosome 5, is necessary for the upregulation of the ABC-transporter genes CDR1 and CDR2, which mediate azole resistance...
  10. ncbi Diagnostic strategy using a modified clinical decision rule and D-dimer test to rule out pulmonary embolism in elderly in- and outpatients
    Maaike Sohne
    Academic Medical Center, Department of Vascular Medicine, Room F4 136, Meibergdreef 9, 1105 AZ Amsterdam
    Thromb Haemost 94:206-10. 2005
    ..The safety and efficacy of the combination of a clinical probability (CDR) and d-dimer test in excluding pulmonary embolism in this group is unclear...
  11. ncbi Evolution of blood pressure in patients with Alzheimer's disease: a one year survey of a French Cohort (REAL.FR)
    O Hanon
    Department of Geriatrics, Hopital Broca, 75013 Paris, France
    J Nutr Health Aging 9:106-11. 2005
    ..To determine the evolution of blood pressure in patients with moderate Alzheimer's disease among a one year longitudinal survey and to evaluate the relationship between blood pressure and cognitive functions...
  12. doi Cognitive changes after parathyroidectomy in patients with secondary hyperparathyroidism
    Fong Fu Chou
    Department of Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Surgery 143:526-32. 2008
    ..Cognitive impairment was frequently reported in uremic patients with dialysis, but improvements of cognition after parathyroidectomy for symptomatic secondary hyperparathyroidism have never been reported before...
  13. ncbi [5-aza-2'-deoxycytidine induces changes of histone H3-lysine 9 methylation in bladder tumor cells]
    Na Yang
    Department of Clinical Laboratory Medicine, Shanghai Tenth People s Hospital, Tongji University, Shanghai 200072, China
    Zhonghua Yi Xue Za Zhi 88:2295-8. 2008
    To investigate the effect of DNA methyltransferases inhibitor 5-aza-2'-deoxycytidine (5-Aza-CdR) on the histone H3-lysine 9 methylation status and gene expression of RUNX3 in human bladder tumor cells.
  14. pmc Orbital fracture clinical decision rule development: burden of disease and use of a mandatory electronic survey instrument
    Kabir Yadav
    Department of Emergency Medicine, The George Washington University, Washington, DC, USA
    Acad Emerg Med 18:313-6. 2011
    In preparation for development of a clinical decision rule (CDR) to promote more efficient use of computed tomography (CT) for diagnosing orbital fractures, the authors sought to estimate the annual incidence of orbital fractures in ..
  15. doi Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine
    Maryse Lemaire
    Departement de Pharmacologie, Universite de Montreal, QC, Canada
    Cancer Chemother Pharmacol 63:411-6. 2009
    ..deaminase with respect to the antineoplastic action of inhibitors of DNA methylation, 5-aza-2'-deoxycytidine (5-AZA-CdR) and zebularine. Zebularine has a dual mechanism of action, since it can also inhibit CR deaminase...
  16. ncbi 2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia
    M Koshy
    University of Illinois at Chicago, Chicago, IL, USA
    Blood 96:2379-84. 2000
    ..For patients with no HbF elevation after HU treatment, augmentation of HbF levels by 5-aza-2'-deoxycytidine (5-aza-CdR, decitabine) could serve as an alternate mode of treatment...
  17. ncbi Non-neurological factors are implicated in impairments in gait and mobility among patients in a clinical dementia referral population
    Vince Salazar Thomas
    Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Int J Geriatr Psychiatry 17:128-33. 2002
    ..Gait disorders were very prevalent at each level of cognitive function [58.7% for CDR=0, 68.0% for CDR=0.5, 57.9% for CDR=1, 68.1% for CDR=2 and 76.9% for CDR=3, p=0...
  18. ncbi The increased flexibility of CDR loops generated in antibodies by Congo red complexation favors antigen binding
    Marcin Krol
    Dept of Bioinformatics and Telemedicine, Medical College, Jagiellonian University, Kopernika 17, 31 501 Krakow, Poland
    J Biomol Struct Dyn 23:407-16. 2006
    ..The higher fluctuation of CDR-bearing loops enhances antigen binding, and allows even low-affinity antibodies to be engaged in immune complexes...
  19. ncbi Combination of a thiazide, a vasodilator and reserpine compared with methyldopa plus hydrochlorothiazide in the treatment of hypertension in Zimbabwe
    C M Stein
    Department of Clinical Pharmacology, University of Zimbabwe, Harare
    S Afr Med J 77:243-5. 1990
    ..5 mg) and reserpine (0.1 mg) (CDR) was compared with methyldopa (MD) plus hydrochlorothiazide (HCT) for antihypertensive effect, adverse reactions, ..
  20. ncbi Urban and rural differences in mortality and causes of death in historical Poland
    Alicja Budnik
    Department of Anthropology, Adam Mickiewicz University, 61 614 Poznan, Poland
    Am J Phys Anthropol 129:294-304. 2006
    ..Mortality measures such as crude death rate (CDR), infant death rate (IDR), and neonatal and postneonatal death rates were calculated...
  21. ncbi Interaction of lysozyme with synthetic anti-lysozyme D1.3 antibody fragments studied by affinity chromatography and surface plasmon resonance
    E Lasonder
    Laboratory of Medical Microbiology, University of Groningen, Netherlands
    J Chromatogr A 676:91-8. 1994
    ..3 show interaction with lysozyme. Surface plasmon resonance with immobilized CDR peptides showed that this interaction is not based on the antigen-antibody interaction...
  22. ncbi Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase
    C J Winters
    Department of Medicine, Medical College of Virginia, Richmond 23298
    Biochemistry 29:1080-7. 1990
    ..This reaction is controlled by a cytosolic enzyme, chlordecone reductase (CDR), which may be of the aldo-keto reductase family of xenobiotic metabolizing enzymes [Molowa et al. (1986) J. Biol...
  23. ncbi [A longitudinal study of the course of Alzheimer type dementia]
    J A Tellería-Díaz
    Hospital Clinico Quirurgico Hermanos Ameijeiras, La Habana, Cuba
    Rev Neurol 25:1551-6. 1997
    ..We carried out a prospective longitudinal study of 41 patients diagnosed as probably having a mild form of Alzheimer's disease according to the data of an investigation of prevalence done in 1991 in the municipality of Habana Vieja...
  24. pmc Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates
    Alix Coste
    Institute of Microbiology, University of Lausanne and University Hospital Center, Rue du Bugnon 48, CH 1011, Lausanne, Switzerland
    Eukaryot Cell 6:1889-904. 2007
    TAC1 (for transcriptional activator of CDR genes) is critical for the upregulation of the ABC transporters CDR1 and CDR2, which mediate azole resistance in Candida albicans...
  25. pmc Genome-wide expression and location analyses of the Candida albicans Tac1p regulon
    Teresa T Liu
    Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Eukaryot Cell 6:2122-38. 2007
    ..To identify the Tac1p regulon, we analyzed four matched sets of clinical isolates representing the development of CDR1- and CDR2-mediated azole resistance by using gene expression profiling...
  26. doi Analysis of paediatric drowning deaths in Washington State using the child death review (CDR) for surveillance: what CDR does and does not tell us about lethal drowning injury
    Linda Quan
    University of Washington School of Medicine, Seattle, USA
    Inj Prev 17:i28-33. 2011
    Drowning is second cause of paediatric injury death in Washington State. Child death review (CDR) data provide the unique opportunity to identify regional risk factors and opportunities for drowning prevention.
  27. doi Using effectiveness and cost-effectiveness to make drug coverage decisions: a comparison of Britain, Australia, and Canada
    Fiona M Clement
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 302:1437-43. 2009
    ..This study describes how that evidence has been used across 3 jurisdictions (Australia, Canada, and Britain) that have been at the forefront of evidence-based coverage internationally...
  28. ncbi [Effects and mechanisms of 5-aza-2'-deoxycytidine on endometrial cancer cell.]
    Yu Quan Zhang
    Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong 226000, China Email
    Zhonghua Fu Chan Ke Za Zhi 44:861-4. 2009
    To investigate the effects and mechanisms of 5-aza-2'-deoxycytidine (5-Aza-CdR) on endometrial cancer cell.
  29. ncbi 5-HT2A/2C receptor and 5-HT transporter densities in mice prone or resistant to chronic high-fat diet-induced obesity: a quantitative autoradiography study
    Xu Feng Huang
    Molecular Neurobiology Laboratory, Smart Food Center, Department of Biomedical Science, University of Wollongong, Northfield Avenue, Wollongong, NSW 2522, Australia
    Brain Res 1018:227-35. 2004
    ..receptors and 5-HT transporters in the brains of chronic high-fat diet-induced obese (cDIO) and obese-resistant (cDR) mice. Thirty-five male mice were used in this study...
  30. ncbi Electronic laboratory reporting for the infectious diseases physician and clinical microbiologist
    Rebecca Wurtz
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Infect Dis 40:1638-43. 2005
    ..Electronic communicable disease reporting (CDR), given its legal mandate and clear public health importance, is a significant early step in the sifting and ..
  31. doi 3-Deazauridine enhances the antileukemic action of 5-aza-2'-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinase
    Noel J M Raynal
    Service of Hematology and Oncology, Université de Montréal and Centre de Recherche, CHU Saint Justine, 3175 Ste Catherine Road, Montreal, Quebec, H3T 1C5 Canada
    Leuk Res 35:110-8. 2011
    ..methylation plays an important role in leukemogenesis of ALL, it can be targeted by 5-aza-2'-deoxycytidine (5-AZA-CdR), a potent inhibitor of DNA methylation. 5-AZA-CdR is a prodrug that is activated by deoxycytidine kinase (DCK)...
  32. ncbi Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications
    Ester Fonsatti
    Division of Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy
    Clin Cancer Res 13:3333-8. 2007
    To investigate the potential of the DNA hypomethylating agent 5-aza-2'-deoxycytidine (5-aza-CdR) to improve the effectiveness of immunotherapeutic approaches against melanocyte differentiation antigens.
  33. ncbi Corpus callosum atrophy, white matter lesions, and frontal executive dysfunction in normal aging and Alzheimer's disease. A community-based study: the Tajiri Project
    Kenichi Meguro
    Division of Neuropsychology, Department of Disability Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int Psychogeriatr 15:9-25. 2003
    ..We investigated the relationship between CC atrophy, WMH, and hippocampal atrophy, together with frontal executive dysfunction in both normal aging and AD...
  34. ncbi Using the cost distribution report in estimating private sector payments: what adjustments should researchers make?
    Gary Nugent
    Nebraska Western Iowa Health Care System, Omaha, NE, USA
    Med Care 41:II80-90. 2003
    ..To reapportion Veterans Health Administration (VA) annual expenditures into benefit categories for comparison with estimated payments by private sector providers...
  35. pmc New methods for estimating the tuberculosis case detection rate in high-HIV prevalence countries: the example of Kenya
    John Mansoer
    US Department of Health and Human Services, Centers for Disease Control and Prevention, Nairobi, Kenya
    Bull World Health Organ 87:186-92, 192A-192B. 2009
    To develop new methods for estimating the sputum smear-positive tuberculosis case detection rate (CDR) in a country where infection with HIV is prevalent.
  36. doi Determinants of deforestation in Nepal's Central Development Region
    Keshav Bhattarai
    Department of Geography, University of Central Missouri, Warrensburg, MO 64093, USA
    J Environ Manage 91:471-88. 2009
    The process of deforestation in the Central Development Region (CDR) of Nepal is diverse in space and time, with rapid deforestation still occurring in areas outside the national parks and wildlife reserves...
  37. pmc Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    T C White
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, and Seattle Biomedical Research Institute, 98109, USA
    Antimicrob Agents Chemother 41:1482-7. 1997
    ..levels of total RNA from these isolates, we observed increased mRNA levels of ERG16 (the 14DM-encoding gene), CDR1 (an ABC transporter), and MDR1 (a major facilitator) in this series...
  38. ncbi A novel monoclonal antibody design for radioimmunotherapy
    Andres Forero
    Department of Medicine, Division of Hematology Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Biother Radiopharm 18:751-9. 2003
    The generation of chimeric and complementary-determining region (CDR) grafted monoclonal antibodies (MAb) have reduced the immunogenicity problem in the clinical application of radioimmunotherapy with monoclonal antibodies...
  39. doi Biochemical markers in persons with preclinical familial Alzheimer disease
    J M Ringman
    UCLA Department of Neurology, Alzheimer Disease Research Center, 10911 Weyburn Ave, Suite 200, Los Angeles, CA 90095 7226, USA
    Neurology 71:85-92. 2008
    ..Persons at risk for familial Alzheimer disease (FAD) provide a model in which biomarkers can be studied in presymptomatic disease...
  40. ncbi Medicine reimbursement recommendations in Canada, Australia, and Scotland
    Joel Lexchin
    School of Health Policy and Management, York University, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    Am J Manag Care 14:581-8. 2008
    This study was undertaken to compare the recommendations made by the Canadian Common Drug Review (CDR) regarding whether drugs should be listed on provincial and federal formularies with recommendations made by similar bodies in other ..
  41. pmc Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region
    Gilad Ofek
    Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 84:2955-62. 2010
    ..Here, we mutationally alter a hydrophobic patch on the third complementarity-determining region of the heavy chain (CDR H3) of the 2F5 antibody and assess the abilities of altered 2F5 variants to bind gp41 and to neutralize diverse ..
  42. pmc Utility of the clinical dementia rating in Asian populations
    Wee Shiong Lim
    Department of Geriatric Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
    Clin Med Res 5:61-70. 2007
    ..The Clinical Dementia Rating (CDR) is an informant-based global assessment scale with established reliability and validity that has been widely ..
  43. ncbi Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations
    Vlastimil Král
    Department of Recombinant Expression and Structural Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 166 37 Prague, Czech Republic
    Proteins 71:1275-87. 2008
    ..of the crystal structures of free Fab M75 and its complex with the epitope peptide reveal major readjustments of CDR-H1 and CDR-H3...
  44. doi Brain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve
    Anthony F Fotenos
    Division of Biology and Biomedical Sciences, Washington University Medical School, St Louis, Missouri, USA
    Arch Neurol 65:113-20. 2008
    ..To assess the relation between socioeconomic status (SES) and structural brain change in nondemented older adults and to ascertain the potential role of preclinical Alzheimer disease (AD)...
  45. ncbi Differential expression of dopamine D2 and D4 receptor and tyrosine hydroxylase mRNA in mice prone, or resistant, to chronic high-fat diet-induced obesity
    Xu Feng Huang
    Department of Biomedical Science, Molecular Neurobiology Laboratory, University of Wollongong, NSW2522, Australia
    Brain Res Mol Brain Res 135:150-61. 2005
    ..and tyrosine hydroxylase (TH) mRNA expression in chronic high-fat diet-induced obese (cDIO) and obese-resistant (cDR) mice...
  46. ncbi Behavioral and psychological symptoms of dementia characteristic of mild Alzheimer patients
    Jin Shimabukuro
    Department of Psychiatry, Tohoku University Hospital, Sendai, Japan
    Psychiatry Clin Neurosci 59:274-9. 2005
    ..BPSD) in patients with mild Alzheimer's disease (AD), BPSD among the severities of Clinical Dementia Rating (CDR) in 74 patients with AD were compared using the Neuropsychiatric inventory (NPI)...
  47. ncbi Increased expression and hotspot mutations of the multidrug efflux transporter, CDR1 in azole-resistant Candida albicans isolates from vaginitis patients
    Chung Yeng Looi
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    FEMS Microbiol Lett 249:283-9. 2005
    The aims of our research were to investigate the gene expression of the multidrug efflux transporter, CDR1 and the major drug facilitator superfamily transporter, MDR1 gene in azole drug-resistant Candida albicans and Candida glabrata ..
  48. ncbi An audit of intra-oral digital radiographs for endodontics
    R Austin
    Department of Primary Dental Care, King s College London Dental Institute, London, UK
    Int Endod J 43:351. 2010
    ..There were three phases. The first phase compared the Schick CDR system with Digora Optime...
  49. pmc Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo
    Bushra Ateeq
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Neoplasia 10:266-78. 2008
    The mechanism of action of DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR), a potential anticancer agent is believed to be activated by the demethylation of tumor suppressor genes...
  50. ncbi Evaluation of a data warehouse in an academic health sciences center
    J R Schubart
    Department of Health Evaluation Sciences, University of Virginia School of Medicine, P O Box 800717, Charlottesville, VA 22908 0717, USA
    Int J Med Inform 60:319-33. 2000
    The Clinical data repository (CDR) at the University of Virginia Health System is a data warehouse that provides direct access to data for clinical research and effective decision making...
  51. ncbi Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies
    John Paul Vermitsky
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA
    Mol Microbiol 61:704-22. 2006
    ..the predominant mechanism behind azole resistance is upregulated expression of multidrug transporter genes CDR1 and PDH1...
  52. ncbi The clinical dementia rating sum of box score in mild dementia
    C A Lynch
    Mercer s Institute for Research on Ageing, St James s Hospital, Dublin, Ireland
    Dement Geriatr Cogn Disord 21:40-3. 2006
    ..The Clinical Dementia Rating (CDR) scale is a widely used dementia staging instrument, yielding a global score and a summated score (sum of box score)..
  53. ncbi Decreased response of osteoblasts obtained from aged Cohen diabetic sensitive rats to sex steroid hormones and 1,25OH2D3 in culture
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, P O B 12272, 91120 Jerusalem, Israel
    Odontology 94:38-43. 2006
    ..The Cohen diabetic model consists of a diabetic-sensitive strain [CDs; diabetic] and a diabetic-resistant strain [CDr; normal])...
  54. ncbi [Effect of a methylation inhibitor 5-aza-2'-deoxycytidine on SHP-1 gene expression, proliferation and apoptosis in K562 cells]
    Jian Min Luo
    Department of Hematology, Hebei Medical University Shijiazhuang 050000, Hebei Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:309-14. 2009
    The aim of this study was to investigate the regulation of 5-aza-CdR on transcription of SHP-1 gene and effects on the proliferation and apoptosis of K562 cells...
  55. ncbi Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene
    D Sanglard
    Institut de Microbiologie Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Microbiology 143:405-16. 1997
    ..When the disruption of CDR2 was performed in the background of a mutant in which CDR1 was deleted, the resulting double delta cdr1 delta cdr2 mutant was more susceptible to these agents than the single ..
  56. ncbi Mechanism for the decrease in the accumulation of cadmium (Cd) in Cd-resistant Chinese hamster V79 cells
    N Tsuchiya
    Department of Environmental Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan
    Arch Toxicol 68:325-31. 1994
    The mechanism for the decrease in the accumulation of cadmium (Cd) in Cd-resistant Chinese hamster V79 (Cdr) cells in culture was investigated in a comparison with Cd-sensitive (Cds) cells...
  57. doi An initial assessment of the consumer demand roundtable: Results and promise
    Dianne C Barker
    Barker Bi Coastal Health Consultants, Inc, Calabasas, California 91302, USA
    Am J Prev Med 38:S437-46. 2010
    An initial assessment of the National Tobacco Cessation Collaborative's (NTCC) 2005-2007 Consumer Demand Roundtable (CDR) was conducted in 2008 to assess the results and products of CDR, and to offer recommendations to guide ongoing NTCC ..
  58. ncbi An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment
    Haiying Wang
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xueyuan Road, Beijing, China
    J Biol Chem 283:2564-74. 2008
    ..was investigated in the human cancer cell lines A549 and HCT116 in response to 5-aza-2'-deoxycytidine (5-aza-CdR) or cytarabine treatment...
  59. ncbi [Effect of (-)-epigallocatechin-3-gallate and 5-AZA-CdR on expression of X-linked inhibitor of apoptosis protein-associated factor 1 in human leukemia HL-60 and K562 cells]
    Yun yan Huang
    Department of Pediatrics, College of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:204-8. 2008
    ..factor 1 (Xaf1) in human leukemia HL-60 and K562 cells treated with interferon alpha (INFalpha) and the demethylating agent 5-AZA-CdR, and observe the synergetic antitumor effect of Xaf1 inducer and (-)-epigallocatechin-3-gallate (EGCG).
  60. doi Feasibility study of volumetric modulated arc therapy with constant dose rate for endometrial cancer
    Ruijie Yang
    Department of Radiation Oncology, Peking University Third Hospital, Beijing, China
    Med Dosim 38:351-5. 2013
    ..feasibility, efficiency, and delivery accuracy of volumetric modulated arc therapy with constant dose rate (VMAT-CDR) for whole-pelvic radiotherapy (WPRT) of endometrial cancer...
  61. pmc Antigen-binding specificities of antibodies are primarily determined by seven residues of VH
    S Ohno
    Proc Natl Acad Sci U S A 82:2945-9. 1985
    ..automatically relegates subsidiary roles to VL as a whole and to the complementarity-determining region 3 (CDR-3) of VH encoded by independent diversity (D) and joining (J) coding segments in determining antigen-binding ..
  62. doi Pitfall Intention Explanation Task with Clue Questions (Pitfall task): assessment of comprehending other people's behavioral intentions in Alzheimer's disease
    Tomoharu Yamaguchi
    Gunma University Graduate School of Health Sciences, Gunma, Japan
    Int Psychogeriatr 24:1919-26. 2012
    ..To evaluate deficits of contextual understanding/ToM, we developed the Pitfall Intention Explanation Task with Clue Questions (Pitfall task)...
  63. doi Effects of education on very mild dementia among Chinese people in Hong Kong: potential mediators in the Cantonese Mini-Mental State Examination tasks
    C S Tse
    Department of Educational Psychology, The Chinese University of Hong Kong, Hong Kong, China
    Aging Ment Health 17:310-8. 2013
    ..examined the effect of education on very mild Alzheimer's disease (AD), as quantified by Clinical Dementia Rating (CDR) scale (CDR 0.5 versus 0), in a Chinese community...
  64. pmc Symptoms of Early Dementia-11 Questionnaire (SED-11Q): A Brief Informant-Operated Screening for Dementia
    Yohko Maki
    Gunma University School of Health Sciences, Gunma University of Health and Welfare, Maebashi, Japan Geriatrics Research Institute and Hospital, Gunma University of Health and Welfare, Maebashi, Japan
    Dement Geriatr Cogn Dis Extra 3:131-42. 2013
    ..individuals participated, including 39 with mild cognitive impairment in the Clinical Dementia Rating scale (CDR) 0.5, 233 with mild dementia in CDR 1, 106 with moderate dementia in CDR 2, and 81 normal controls in CDR 0...
  65. doi Cytotoxicity of 5-Aza-2'-deoxycytidine against gastric cancer involves DNA damage in an ATM-P53 dependent signaling pathway and demethylation of P16(INK4A)
    Juan Liu
    Department of Geriatrics, Renmin Hospital of Wuhan University, Wuchang District, Wuhan, PR China
    Biomed Pharmacother 67:78-87. 2013
    The DNA methylation inhibitor 5-Aza-2'-deoxycytidine (5-Aza-CdR) has increasingly attracted worldwide attention for its antineoplastic potential...
  66. pmc A new 3D method for measuring cranio-facial relationships with cone beam computed tomography (CBCT)
    Natalia Zamora
    Department of Orthodontics, Faculty of Medicine and Dentistry, University of Valencia, Valencia, Spain
    Med Oral Patol Oral Cir Bucal 18:e706-13. 2013
    ..The aims are to analyse cranio-facial relationships in a sample of patients who had previously undergone a CBCT and create a new 3D cephalometric method for assessing and measuring patients...
  67. ncbi Selective effects of electrostatic changes in the CD4 CDR-3-like loop on infection by different human immunodeficiency virus type 1 isolates
    N Signoret
    Centre d immunologie de Marseille Luminy, France
    AIDS Res Hum Retroviruses 12:1001-13. 1996
    The role of the CDR-3-like loop of the first domain of the CD4 molecule in infection by the human immunodeficiency virus type 1 (HIV-1) is controversial...
  68. ncbi Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures
    Michael Zemlin
    Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294 3300, USA
    J Mol Biol 334:733-49. 2003
    ..junctional diversity is concentrated in the third complementarity-determining region of the heavy chain (CDR-H3), which often plays a dominant role in antigen binding...
  69. pmc Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variation
    Uri Hershberg
    Department of Laboratory Medicine and Section of Immunobiology, Yale University School of Medicine, 1 Gilbert Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 103:15963-8. 2006
    ..chains have evolved to overexpress codons prone to amino acid change in their complementarity determining regions (CDR) compared with the framework (FW) regions...
  70. ncbi Identifying subpopulations of thymic epithelial cells by flow cytometry using a new specific thymic epithelial marker, Ly110
    Soo Jung Yang
    Thymic Molecular Development Unit, Laboratory of Cellular and Molecular Immunology, NIAID, NIH, USA
    J Immunol Methods 297:265-70. 2005
    ..TSCOT/Ly110 expressing subpopulation can be identified among the CDR1(+) or 6C3(+) cortical epithelial cells...
  71. ncbi Induction of gene expression by 5-Aza-2'-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms
    K Schmelz
    Charite, Department of Hematology and Oncology, Virchow Clinic, Internal Medicine, Universitatsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Leukemia 19:103-11. 2005
    The methylation inhibitor 5-Aza-2'-deoxycytidine (5-Aza-CdR, decitabine) has therapeutic efficacy in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)...
  72. ncbi Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering
    Stefan Ewert
    Biochemisches Institut, Universitat Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Methods 34:184-99. 2004
    ..While CDR grafting from a non-human to the most closely related human antibody framework is an established technique to ..
  73. ncbi SRE1 and SRE2 are two specific steroid-responsive modules of Candida drug resistance gene 1 (CDR1) promoter
    Neerja Karnani
    School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Yeast 21:219-39. 2004
    b>CDR1 gene encoding an ATP-driven drug extrusion pump has been implicated in the development of azole-resistance in Candida albicans...
  74. doi Dietetics trends as reflected in various primary research projects, 1995-2011
    Dick Rogers
    Readex Research, Stillwater, MN 55082, USA
    J Acad Nutr Diet 112:S64-74. 2012
    At the behest of the Commission on Dietetic Registration (CDR) Workforce Demand Task Force, a retrospective examination and reanalysis of 12 primary research projects (sponsored by CDR and/or the Academy of Nutrition and Dietetics ..
  75. ncbi Montreal cognitive assessment in assessing clinical severity and white matter hyperintensity in Alzheimer's disease with normal control comparison
    Ya Ting Chang
    Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Acta Neurol Taiwan 21:64-73. 2012
    ..Use Taiwanese version of the Montreal Cognitive Assessment (MoCA) in evaluating patients in different stages of Alzheimer's disease (AD) and correlate with white matter change...
  76. doi Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions
    Joseph M Perchiacca
    Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Proteins 79:2637-47. 2011
    ..distributed property of the CDR loops, but can be localized to aggregation hotspots within and near the first CDR (CDR1)...
  77. doi Use of child death review to inform sudden unexplained infant deaths occurring in a large urban setting
    Suzanne N Brixey
    Department of Pediatrics, Policy Core, Injury Research Center, Medical College of Wisconsin, Downtown Health Center Pediatric Clinic, Milwaukee, Wisconsin, USA
    Inj Prev 17:i23-7. 2011
    To illustrate the benefits and utility of the child death review (CDR) reporting system when examining risk factors associated with infant death occurring within two subgroups of sudden unexpected infant deaths (SUID)-unintentional ..
  78. pmc Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41
    Elena Gustchina
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 6:e1001182. 2010
    ..a mimetic of the trimeric N-HR coiled coil, followed by affinity maturation using targeted diversification of the CDR-H2 loop...
  79. doi Assessment of caregiver responsibility in unintentional child injury deaths: challenges for injury prevention
    Patricia G Schnitzer
    Sinclair School of Nursing, University of Missouri, Columbia, Missouri, USA
    Inj Prev 17:i45-54. 2011
    ..supervision or failure to protect could be classified as child neglect is a component of child death review (CDR) in most states...
  80. doi Identifying functional impairment with scores from the repeatable battery for the assessment of neuropsychological status (RBANS)
    Valerie L Hobson
    Department of Psychology, Texas Tech University, Lubbock, TX, USA
    Int J Geriatr Psychiatry 25:525-30. 2010
    To examine the link between RBANS scores and functional impairment. Functional status was evaluated through informant report using the clinical dementia rating (CDR) scale.
  81. pmc The CDR-H3 repertoire from TdT-deficient adult bone marrow is a close, but not exact, homologue of the CDR-H3 repertoire from perinatal liver
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:6075-84. 2010
    Compared with adult bone marrow (BM), the composition of the perinatal liver CDR-3 of the Ig H chain (CDR-H3) repertoire is marked by a paucity of N nucleotides and by enrichment for use of J(H) proximal DQ52 and D(H) proximal V(H) and J(..
  82. doi Health economic effect of donepezil treatment for CDR 0.5 converters to Alzheimer's disease as shown by the Markov model
    Masashi Kasuya
    Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, 980 8575 Sendai, Japan
    Arch Gerontol Geriatr 50:295-9. 2010
    ..Namely, Simulation A hypothesized that mild AD patients, i.e., Clinical Dementia Rating (CDR) 1, received donepezil as in the previous study. Simulation B hypothesized that all CDR 0...
  83. pmc A new clustering of antibody CDR loop conformations
    Benjamin North
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Mol Biol 406:228-56. 2011
    ..Because of the widespread utility of antibodies, we have revisited the clustering of conformations of the six CDR loops with the much larger amount of structural information currently available...
  84. pmc The persistence of tuberculosis in the age of DOTS: reassessing the effect of case detection
    David W Dowdy
    Center for Tuberculosis Research, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21221, USA
    Bull World Health Organ 87:296-304. 2009
    ..To investigate whether short-term annual declines of 5-10% in the incidence of tuberculosis (TB) can be sustained over the long term by maintaining high case detection rates (CDRs)...
  85. doi 5-Aza-2'-deoxycytidine reactivates gene expression via degradation of pRb pocket proteins
    Zhixing Zheng
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
    FASEB J 26:449-59. 2012
    Not only does 5-aza-2'-deoxycytidine (5-aza-CdR) induce the reexpression of silenced genes through the demethylation of CpG islands, but it increases the expression of unmethylated genes...
  86. ncbi [Relationship between the regional cerebral blood flow and the cognitive function and anosmia in patients with Parkinson disease and Alzheimer disease]
    Kazuhiro Imamura
    Department of Neurology, Okazaki City Hospital, 3 1 Goshoai, Koryuji cho, Okazaki, Aichi 444 8553, Japan
    Brain Nerve 61:683-90. 2009
    ..UPDRS III, MMSE, HDS-R, CDR, Beck Depression Inventory (BDI) were employed in this study. The subjects included 56 PD patients (average age 71...
  87. pmc Cell line-dependent variability in HIV activation employing DNMT inhibitors
    Guerau Fernandez
    Center for Cancer and Immunology Research, Children s Research Institute, Children s National Medical Center, Washington, DC, USA
    Virol J 7:266. 2010
    ..DNA methyltransferases (DNMT) inhibitors like 5-aza-2'deoxycytidine (Aza-CdR) and histone deacetylase (HDAC) inhibitors like Trichostatin A (TSA) have been proposed as agents to enhance ..
  88. pmc Fluconazole transport into Candida albicans secretory vesicles by the membrane proteins Cdr1p, Cdr2p, and Mdr1p
    Luiz R Basso
    Division of Infectious Diseases, Department of Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Eukaryot Cell 9:960-70. 2010
    A major cause of azole resistance in Candida albicans is overexpression of CDR1, CDR2, and/or MDR1, which encode plasma membrane efflux pumps...
  89. doi Renal and systemic effects of endothelin-1 in diabetic-hypertensive rats
    Cipy Hofman
    Hypertension Research Unit, Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Israel
    Clin Exp Hypertens 33:444-54. 2011
    ..which genetic hypertension and diabetes developed after crossbreeding of Cohen diabetic rats sensitive substrain (CDR) and spontaneously hypertensive rats (SHR)...
  90. ncbi [Molecular mechanisms of fluconazole resistance in clinical isolates of Candida glabrata]
    Yin Zhong Shen
    Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 201508, China
    Zhonghua Nei Ke Za Zhi 49:245-9. 2010
    To determine if changes in the levels of expression of ERG11, CDR1 and CDR2 genes could be associated with resistance phenotype in clinical isolates of Candida glabrata (C. glabrata).
  91. pmc GSTP1 DNA methylation and expression status is indicative of 5-aza-2'-deoxycytidine efficacy in human prostate cancer cells
    Karen Chiam
    Dame Roma Mitchell Cancer Research Laboratories, Discipline of Medicine, University of Adelaide, Hanson Institute, Adelaide, Australia
    PLoS ONE 6:e25634. 2011
    ..LNCaP prostate cancer cells were treated with 5-aza-2'-deoxycytidine (5-aza-CdR) either with a single high dose (5-20 µM), every alternate day (0.1-10 µM) or daily (0.005-2.5 µM)...
  92. doi Application of a decision rule and a D-dimer assay in the diagnosis of pulmonary embolism
    Nadine S Gibson
    Department of Vascular Medicine, Academical Medical Center, Amsterdam, The Netherlands
    Thromb Haemost 103:849-54. 2010
    Current strategies for diagnosing pulmonary embolism (PE) include a clinical decision rule (CDR), followed by a D-dimer assay in patients with an unlikely clinical probability...
  93. ncbi Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells
    N Sacchi
    Department of Biology and Genetics, School of Medicine, University of Milan, Italy
    Oncogene 16:2609-15. 1998
    ..factor A2 (CBFA2) on chromosome 21, and a gene on chromosome 8, hereafter referred to as MTG8, but also known as CDR and ETO...
  94. doi The ROSE (risk stratification of syncope in the emergency department) study
    Matthew J Reed
    Department of Emergency Medicine, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    J Am Coll Cardiol 55:713-21. 2010
    The aim of this study was to develop and validate a clinical decision rule (CDR) to predict 1-month serious outcome and all-cause death in patients presenting with syncope to the emergency department.
  95. doi Correlation of findings in advanced MR techniques with global severity scales in patients with some grade of cognitive impairment
    Nicolas Fayed
    Department of Radiology, Quiron Hospital, Paseo Mariano Renovales s n, Zaragoza 50006, Spain
    Neurol Res 32:157-65. 2010
    ..results of perfusion- and diffusion-weighted imaging and magnetic resonance spectroscopy with the results of two global severity scales in cognitive impairment: the clinical dementia rating (CDR) and the global deterioration scale (GDS).
  96. ncbi Hypomethylation-induced expression of S100A4 increases the invasiveness of laryngeal squamous cell carcinoma
    Jia Liu
    Department of Medical Genetics, China Medical University, Shenyang 110001, PR China
    Oncol Rep 23:1101-7. 2010
    The present study aimed to identify genes related to 5AZA-CdR in laryngeal squamous cell carcinoma (LSCC) and to investigate the role of S100A4 in the development and aggression of LSCC...
  97. ncbi Overexpression of CDR1 and CDR2 genes plays an important role in fluconazole resistance in Candida albicans with G487T and T916C mutations
    L M Chen
    Department of Dermatology, Qilu Hospital of Shandong University, Jinan, China
    J Int Med Res 38:536-45. 2010
    ..The CDR1 and CDR2 genes were upregulated in all the fluconazole-resistant C...
  98. pmc Ncb2 is involved in activated transcription of CDR1 in azole-resistant clinical isolates of Candida albicans
    Shipra Shukla
    Special Centre for Molecular Medicine and Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Eukaryot Cell 10:1357-66. 2011
    We recently demonstrated that CDR1 overexpression in azole-resistant isolates of Candida albicans is due to its enhanced transcriptional activation and increased mRNA stability...
  99. doi Safety of excluding acute pulmonary embolism based on an unlikely clinical probability by the Wells rule and normal D-dimer concentration: a meta-analysis
    S M Pasha
    Section of Vascular Medicine, Department of General Internal Medicine Endocrinology, LUMC, Leiden, The Netherlands
    Thromb Res 125:e123-7. 2010
    The Wells clinical decision rule (CDR) and D-dimer tests can be used to exclude pulmonary embolism (PE)...
  100. pmc Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse
    Y T Chen
    Samuel Freeman Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Proc Natl Acad Sci U S A 87:3077-81. 1990
    Cerebellar degeneration-related antigen (designated CDR34) was previously cloned by antibody screening of a cDNA library and was shown to be one of the target molecules recognized by autoantibodies in patients with paraneoplastic ..
  101. pmc 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal
    Kalpana Ghoshal
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell Biol 25:4727-41. 2005
    5-Azacytidine- and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor suppressor genes silenced by promoter methylation has provided an alternate approach in cancer therapy...

Research Grants92

  1. DELIRIUM IN PERSONS WITH DEMENTIA
    Donna Fick; Fiscal Year: 2007
    ..of Daily Living Scale (IADL), Charlson Co-morbidity Index, Apache II, the Clinical Dementia Rating scale (CDR), a family semi-structured interview form, and a Modified Blessed Scale...
  2. AAC Rehabilitation for Conversation in Dementia
    Melanie Fried Oken; Fiscal Year: 2006
    ..Participants are 60 adults with moderate dementia as defined by a CDR score of 2, MMSE between 5-15, and enrollment in the Oregon Alzheimer's Disease Center...
  3. MOLECULAR ANALYSIS OF CD8-MHC CLASS I INTERACTION
    Paula Kavathas; Fiscal Year: 1993
    ..Our published work on mutations in CD8alpha indicate that the CDR1 and CDR2 loops are important for binding...
  4. Role of IG CDR-H3 in Responses to HIV Vaccines
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2010
    ..the norm in that each of their antigen binding sites contain a long, H chain complementarity determining region 3 (CDR-H3) that lacks tyrosine and includes patches of hydrophobic and charged amino acids...
  5. MURINE MODELS OF GENERALIZED AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 1990
    ..probes to define the usage patterns of VH-VL, gene families, joining (J), and complementarity-determining region (CDR) elements...
  6. SELECTION OF T CELL RECEPTOR V-ALPHA REGIONS
    NICHOLAS GASCOIGNE; Fiscal Year: 2001
    ..Interestingly, single amino acid substitutions in the complementarity determining region 1 (CDR1) or CDR2 of a V-alpha (Va) protein can change it from being selected into the CD4 subset to being selected into the ..
  7. The role of T cell repertoire selection in the NOD mouse model of MOG-induced EAE
    Anthony Quinn; Fiscal Year: 2007
    ..Since CDR1 and CDR2 of the TCR V beta 8 chain are encoded by BV8, our findings suggests that the MOG reactive T cell ..
  8. Cocaine degradation: Improving antibody efficacy
    KATHLEEN MCKENZIE; Fiscal Year: 2006
    ..The first involves affinity maturation by complementarity determining region (CDR) walking based on unpublished crystal structure results from the Wilson and Janda laboratories, while the second ..
  9. EVOLUTION OF ADAPTIVE IMMUNITY
    Martin Flajnik; Fiscal Year: 1999
    ..a very high frequency of somatic mutation (up to 12% in cDNA clones that have been analyzed) concentrated in the CDR. The hypothesis is that NAR is found on the surface of cells in the shark (and perhaps other vertebrates) that are ..
  10. Conformationally-Constrained PA Anthrax Vaccine
    Maurizio Zanetti; Fiscal Year: 2005
    ..crystallography studies characterized this loop as having the structure of the complementarity-determining region (CDR) of an immunoglobulin (Ig)...
  11. Epigenetic regulation of HIV latency
    ERIC M VERDIN; Fiscal Year: 2010
    ..We also found that the inhibitor of DNA methylation, 5-aza-2'deoxycytidine (aza-CdR), synergizes with NF-B activators to reactivate latent HIV...
  12. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 1993
    ..Additionally, we have synthesized peptides with sequences corresponding to the complementarity determining regions (CDR) of encephalitogenic T cell receptor chains, thought to be important in ligand binding...
  13. Mechanisms of Cutaneous Drug Reactions
    CRAIG SVENSSON; Fiscal Year: 2004
    Cutaneous drug reactions (CDR) are among the most frequent adverse medical events. Recent studies suggest that between 30 and 45 percent of all adverse drug reactions involve the skin...
  14. IMMUNOLOGIC MECHANISMS OF LUPUS NEPHRITIS
    Michael Madaio; Fiscal Year: 1993
    ..Oligonucleotide probes specific for CDR1 and CDR2 of the V genes used to encode pathogenic Ig will be utilized to select Ig from our existing panel of ..
  15. Therapeutic Effects of Cataract Removal in Alzheimer's Disease
    GROVER CLEVELAND GILMORE; Fiscal Year: 2010
    ..Patients will be stratified by AD severity (CDR mild or moderate) and cataract severity (LOCS 1-2 or 3-4) prior to being randomized...
  16. AZOLE RESISTANT CANDIDIASIS IN HIV INFECTIONS
    THEODORE WHITE; Fiscal Year: 2001
    ..In surveys of small numbers of clinical isolates, overexpression of CDR pumps, especially CDR1, appears to be the most common mechanism of azole drug resistance...
  17. CLONOTYPIC PCR FOR MINIMAL RESIDUAL DISEASE IN LYMPHOMA
    Ariela Noy; Fiscal Year: 2002
    ..The sequences of greatest diversity comprising complementarity region-III (CDR-III) or the V-beta counterpart provide excellent targets for clone specific MRD probes...
  18. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2007
    ..Preliminary studies showed that development of Cd resistance (CdR) of rat lung fibroblasts (RFL6) following long-term Cd exposure was accompanied by upregulation of cellular ..
  19. Mechanisms of drug resistance in Candida albicans
    Brian Wong; Fiscal Year: 2007
    ..It also is not known if mutations in these pumps' structural genes (CDR1, CDR2 and MDR1) cause azole resistance in clinical C. albicans strains...
  20. Radioimmunotherapy: An Anti-Neoplastic Strategy
    Andres Forero; Fiscal Year: 2006
    ..3. The immunogenicity of mCC49, the long half-life (50h) and the projected even longer half-life of a chimeric or CDR-grafted version led to studies directed at humanization with deletion of various parts in search of a construct ..
  21. AIDS Related Candidiasis: Dynamic Expression of Drug Resistant Genes
    Theodore C White; Fiscal Year: 2010
    ..four genes are known to be constitutively overexpressed include the target enzyme ERG11, and three efflux pumps, CDR1, CDR2, and MDR1. In susceptible Ca, these genes can be transcriptionally induced when exposed to drugs...