CDK5RAP1

Summary

Gene Symbol: CDK5RAP1
Description: CDK5 regulatory subunit associated protein 1
Alias: C20orf34, C42, CGI-05, HSPC167, CDK5 activator-binding protein C42, CDK5 regulatory subunit-associated protein 1
Species: human

Top Publications

  1. ncbi Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1
    Xianqiong Zou
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China
    Genes Genet Syst 79:177-82. 2004
  2. ncbi Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor
    Yick Pang Ching
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 277:15237-40. 2002
  3. ncbi Cloning of three novel neuronal Cdk5 activator binding proteins
    Y P Ching
    Department of Biochemistry, Hong Kong University of Science and Technology, Kowloon
    Gene 242:285-94. 2000
  4. ncbi Intramolecular interaction of SUR2 subtypes for intracellular ADP-Induced differential control of K(ATP) channels
    Kenji Matsushita
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circ Res 90:554-61. 2002
  5. pmc The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA
    Veronika Reiter
    Center for Integrated Protein Science Munich CIPSM, Department of Chemistry, Ludwig Maximilians University, Munich 81377, Germany
    Nucleic Acids Res 40:6235-40. 2012
  6. doi Stereocontrolled total synthesis of fucoxanthin and its polyene chain-modified derivative
    Takayuki Kajikawa
    Department of Chemistry, School of Science and Tchnology, Kwansei Gakuin University, Gakuen, Sanda, Hyogo 669 1337, Japan
    Org Lett 14:808-11. 2012
  7. ncbi Exploring the role of putative active site amino acids and pro-region motif of recombinant falcipain-2: a principal hemoglobinase of Plasmodium falciparum
    Amit Kumar
    International Center for Genetic Engineering and Biotechnology, PO Box No 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Biochem Biophys Res Commun 317:38-45. 2004
  8. ncbi The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels
    Mitsuhiko Yamada
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, Suita, Japan
    Mol Pharmacol 65:1198-207. 2004
  9. ncbi Homology modeling and mutagenesis analyses of Plasmodium falciparum falcipain 2A: implications for rational drug design
    Liuh Ling Goh
    Department of Microbiology, Faculty of Medicine, National University of Singapore, MD4A, 5 Science Drive 2, Singapore 117597, Singapore
    Biochem Biophys Res Commun 323:565-72. 2004
  10. ncbi A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K(+) channels
    Mitsuhiko Yamada
    Department of Pharmacology II, Graduate School of Medicine, Faculty of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Mol Cell Cardiol 39:1-6. 2005

Research Grants

  1. Role of Raf Kinase Inhibitory Protein in Prostate Cancer
    Marsha Rosner; Fiscal Year: 2009
  2. Role of Raf Kinase Inhibitory Protein in Prostate Cancer
    Marsha Rosner; Fiscal Year: 2007
  3. INTERESTING BIOACTIVE SUBSTANCES
    David Williams; Fiscal Year: 2002
  4. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2004
  5. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2009
  6. INTERESTING BIOACTIVE SUBSTANCES
    David Williams; Fiscal Year: 2006
  7. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2009
  8. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2000
  9. INVESTIGATIONS OF INTERESTING BIOACTIVE SUBSTANCES
    David Williams; Fiscal Year: 1993
  10. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 1992

Scientific Experts

  • Gassan Hodaifa
  • Jingjie Mo
  • Dalal Asker
  • Peiyan Sun
  • Frank A Petrigliano
  • Supot Kamsa-Ard
  • G A Grant
  • S Ikegawa
  • Anna Floegel
  • Masayuki Inoue
  • D R Williams
  • Xinwen Chen
  • James D White
  • Ralph W Howard
  • A Fujita
  • Garry W Buchko
  • Aileen F Knowles
  • Y P Ching
  • Marsha Rosner
  • Michael Carroll
  • Minggang Fang
  • Mitsuhiko Yamada
  • Yun Wang
  • Yunping Qiu
  • Kanae Teramoto
  • Tod A Leighfield
  • Yingdi Shi
  • Min Kyung Shin
  • Kazuhiro Takemura
  • Punlop Kuntiyong
  • Trevor Gokey
  • Veronika Reiter
  • Takayuki Kajikawa
  • Santosh Kumar Jha
  • Wei Qi
  • Longjiang Fan
  • Valery Matthys
  • Nan Zhang
  • Hyun Mee Oh
  • Yoshihisa Kurachi
  • R X Faria
  • Tarik Oztürk
  • Kun Li
  • Margaret E Teasdale
  • Clare van Maarseveen
  • Mohammed Hassan El-Mallah
  • Jianhua Song
  • Maria B Padua
  • Qian Wang
  • Subrata Panja
  • Fatima Hakimuddin
  • Wenbi Wu
  • I Torrens
  • David A Theilmann
  • Xiaojiang Dai
  • Fei Deng
  • Kaki Shiva Shanker
  • Amit Kumar
  • Liuh Ling Goh
  • N Suvajdzic
  • Xianqiong Zou
  • Yijun Cui
  • Kenji Matsushita
  • Mingming Su
  • Hiroko Kawasaki
  • Hiroaki Sato
  • Sarah Baxter
  • Takafumi Sato
  • Ken ichiro Suzuki
  • Xiaojiao Zheng
  • Bingsen Zhou
  • Wei Jia
  • Xueqing Zhao
  • John S Ramsdell
  • Christopher O Miles
  • Tomohiko Tamura
  • Noah Muha
  • Satoshi Hanada
  • Yun Yen
  • Teaster T Baird
  • Yoon Kyung Uhm
  • Joo Ho Chung
  • Satoshi Okumura
  • Markus Muller
  • Anton B Guliaev
  • Daisuke Kosumi
  • Akio Kitao
  • Takashi Iwashita
  • Hideki Hashimoto
  • Thomas Carell

Detail Information

Publications67

  1. ncbi Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1
    Xianqiong Zou
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China
    Genes Genet Syst 79:177-82. 2004
    Two novel splice variants of CDK5RAP1, named CDK5RAP1_v3 and CDK5RAP1_v4, were isolated through the large-scale sequencing analysis of a human fetal brain cDNA library...
  2. ncbi Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor
    Yick Pang Ching
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 277:15237-40. 2002
    ..Here we show that one of these proteins, called C42, specifically inhibits the activation of Cdk5 by Nck5a...
  3. ncbi Cloning of three novel neuronal Cdk5 activator binding proteins
    Y P Ching
    Department of Biochemistry, Hong Kong University of Science and Technology, Kowloon
    Gene 242:285-94. 2000
    ..The full-length forms of these three novel proteins, designated C42, C48 and C53, have a molecular mass of 66, 24, and 57 kDa, respectively...
  4. ncbi Intramolecular interaction of SUR2 subtypes for intracellular ADP-Induced differential control of K(ATP) channels
    Kenji Matsushita
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circ Res 90:554-61. 2002
    ..2-channels. The C-terminal 42 amino acid residues (C42) of SURs are responsible for ADP-induced differential activation of K(ATP) channels in SUR-subtypes...
  5. pmc The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA
    Veronika Reiter
    Center for Integrated Protein Science Munich CIPSM, Department of Chemistry, Ludwig Maximilians University, Munich 81377, Germany
    Nucleic Acids Res 40:6235-40. 2012
    ..Recently, CDK5RAP1 was discovered to inhibit the active CDK5 kinase...
  6. doi Stereocontrolled total synthesis of fucoxanthin and its polyene chain-modified derivative
    Takayuki Kajikawa
    Department of Chemistry, School of Science and Tchnology, Kwansei Gakuin University, Gakuen, Sanda, Hyogo 669 1337, Japan
    Org Lett 14:808-11. 2012
    ..The method established for fucoxanthin synthesis was successfully applied to the synthesis of the C42 longer chain analogue.
  7. ncbi Exploring the role of putative active site amino acids and pro-region motif of recombinant falcipain-2: a principal hemoglobinase of Plasmodium falciparum
    Amit Kumar
    International Center for Genetic Engineering and Biotechnology, PO Box No 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Biochem Biophys Res Commun 317:38-45. 2004
    ..Our results showed that substitutions of putative active site residues; Q36, C42, H174, and N204 resulted in complete loss of falcipain-2 activity, while W206 and D155 mutants retained partial/..
  8. ncbi The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels
    Mitsuhiko Yamada
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, Suita, Japan
    Mol Pharmacol 65:1198-207. 2004
    ..Although SUR2A and SUR2B differ only in their C-terminal 42 amino acids (C42) and possess identical drug receptors and nucleotide-binding domains (NBDs), nicorandil more potently activates ..
  9. ncbi Homology modeling and mutagenesis analyses of Plasmodium falciparum falcipain 2A: implications for rational drug design
    Liuh Ling Goh
    Department of Microbiology, Faculty of Medicine, National University of Singapore, MD4A, 5 Science Drive 2, Singapore 117597, Singapore
    Biochem Biophys Res Commun 323:565-72. 2004
    ..The analyses also validated the role of the active triad comprising of C42, H174, and N204 in catalysis and identified a serine at position 149 which is required for specific peptide ..
  10. ncbi A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K(+) channels
    Mitsuhiko Yamada
    Department of Pharmacology II, Graduate School of Medicine, Faculty of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Mol Cell Cardiol 39:1-6. 2005
    ..SUR2A and SUR2B have the identical drug receptor and NBDs and differ only in the C-terminal 42 amino acids (C42). Nonetheless, nicorandil ~100 times more potently activates SUR2B/Kir6.2 than SUR2A/Kir6.2 channels...
  11. doi Simple and rapid characterization of mycolic acids from Dietzia strains by using MALDI spiral-TOFMS with ultra high mass-resolving power
    Kanae Teramoto
    Advanced Technology Department, JEOL Ltd, Akishima, Japan
    J Antibiot (Tokyo) 66:713-7. 2013
    ..For all samples, the distributions of carbon-chain lengths were mainly in the range of C30-C42 and the average number of carbon-chain lengths was about 37, which agreed reasonably well with reported results for ..
  12. ncbi Isolation and characterization of neutral lipids of desilked eri silkworm pupae grown on castor and tapioca leaves
    Kaki Shiva Shanker
    Lipid Science and Technology Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    J Agric Food Chem 54:3305-9. 2006
    ..species showed that the pupal oil is rich in molecular species with equivalent carbon numbers (ECN) C36, C40, C42, C44, and C48. There was a significantly higher level (P < 0...
  13. pmc Mechanism of Kir6.2 channel inhibition by sulfhydryl modification: pore block or allosteric gating?
    Yijun Cui
    Department of Physiology, University of Tennessee Health Science Center, College of Medicine, Memphis, TN 38163, USA
    J Physiol 540:731-41. 2002
    ..The crucial modification has been localized to C42 near the N-terminus of Kir6...
  14. doi Association between CDK5RAP1 polymorphisms and susceptibility to vitiligo in the Korean population
    Min Kyung Shin
    Department of Dermatology, Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
    Eur J Dermatol 22:495-9. 2012
    ..Cyclin-dependent kinase 5 regulatory subunit associated protein 1 (CDK5RAP1) is expressed in neuronal tissues, and cyclin-dependent kinase 5 (CDK5) seems to be critically involved in the ..
  15. doi Water model tuning for improved reproduction of rotational diffusion and NMR spectral density
    Kazuhiro Takemura
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo, Tokyo 113 0032, Japan
    J Phys Chem B 116:6279-87. 2012
    ..tumbling correlation times (τ(p)) from ubiquitin, protein G, bovine pancreatic trypsin inhibitor, and barstar C42/80A were successfully reproduced using the SPC/E(b) model...
  16. ncbi Changes of the wax contents in mixtures of olive oils as determined by gas chromatography with a flame ionization detector
    Gassan Hodaifa
    University of Pablo de Olavide, Molecular Biology and Biochemical Engineering Department, 41013 Seville, Spain
    J AOAC Int 95:1720-4. 2012
    ..In this work, the variations of individual wax esters (C40, C42, C44, and C46), with different degrees of unsaturation content, and total wax esters were studied when extra virgin ..
  17. doi Characterization of disulfide linkages in recombinant human granulocyte-colony stimulating factor
    Jingjie Mo
    Bioanalytical and Discovery Analytical Sciences, Research and Development, Bristol Myers Squibb Company, Princeton, NJ 08543, USA
    Rapid Commun Mass Spectrom 27:940-6. 2013
    ..The reported major disulfide (S-S) linkages in mature human G-CSF are C36 -C42 and C64 -C74 , leaving C17 as a free cysteine, which could potentially result in S-S scrambling...
  18. doi Semisynthesis of radiolabeled amino acid and lipid brevetoxin metabolites and their blood elimination kinetics in C57BL/6 mice
    Tod A Leighfield
    Marine Biotoxins Program, Center for Coastal Environmental Health and Biomolecular Research, NOAA National Ocean Service, Charleston, South Carolina 29412, USA
    Chem Res Toxicol 26:868-77. 2013
    ..BTX-B was reduced at C42 to yield [(3)H] dihydro-BTX-B...
  19. pmc Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach
    Anna Floegel
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Diabetes 62:639-48. 2013
    ..with increased risk of T2D and serum glycine; sphingomyelin C16:1; acyl-alkyl-phosphatidylcholines C34:3, C40:6, C42:5, C44:4, and C44:5; and lysophosphatidylcholine C18:2 with decreased risk...
  20. pmc Mass spectrometry-based quantitative metabolomics revealed a distinct lipid profile in breast cancer patients
    Yunping Qiu
    Center for Translational Medicine and Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai 200233, China
    Int J Mol Sci 14:8047-61. 2013
    ..Using logical regression, a diagnostic equation based on three metabolites (lysoPC a C16:0, PC ae C42:5 and PC aa C34:2) successfully differentiated breast cancer patients from healthy controls, with a sensitivity of ..
  21. ncbi Total synthesis of the marine toxin phorboxazole A using palladium(II)-mediated intramolecular alkoxycarbonylation for tetrahydropyran synthesis
    Punlop Kuntiyong
    Department of Chemistry, Oregon State University, Corvallis, Oregon, USA
    Org Biomol Chem 10:7884-99. 2012
    ..A was synthesized from six subunits comprising C1-C2 (115), C3-C8 (98), C9-C19 (74), C20-C32 (52), C33-C41 (84) and C42-C46 (85)...
  22. ncbi [11'-Deoxyverticillin A induces caspase-dependent cell apoptosis in PC3M cells]
    Yingdi Shi
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Sheng Wu Gong Cheng Xue Bao 28:96-103. 2012
    ..11'-Deoxyverticillin A (C42) belongs to the family of epipolythiodioxopiperazines (ETPs), an interesting class of fungal toxins that inhibit ..
  23. doi Conformational dynamics of threonine 195 and the S1 subsite in functional trypsin variants
    Trevor Gokey
    Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132, USA
    J Mol Model 18:4941-54. 2012
    ..variant) leads to a nearly complete loss of catalytic activity, which can be partially restored by eliminating the C42-C58 disulfide bond. The 0...
  24. pmc The putative pocket protein binding site of Autographa californica nucleopolyhedrovirus BV/ODV-C42 is required for virus-induced nuclear actin polymerization
    Kun Li
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People s Republic of China
    J Virol 84:7857-68. 2010
    ..Previously, we had demonstrated that Autographa californica multiple nucleopolyhedrovirus (AcMNPV) BV/ODV-C42 (C42) is involved in nuclear actin polymerization by recruiting P78/83, an AcMNPV orf9-encoded N-WASP homology ..
  25. doi Composition of the epicuticular and intracuticular wax layers on Kalanchoe daigremontiana (Hamet et Perr. de la Bathie) leaves
    Clare van Maarseveen
    Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1
    Phytochemistry 70:899-906. 2009
    ..2-3%), C26-C36 primary alcohols (4-8%), and C42-C52 alkyl esters (2-9%)...
  26. ncbi Investigation of liquid wax components of Egyptian jojoba seeds
    Mohammed Hassan El-Mallah
    Fats and Oils Department, National Research Centre, Cairo, Egypt
    J Oleo Sci 58:543-8. 2009
    ..7 %. Wax esters composition showed that the local wax had C42 and C40 esters as major components amounted to 51.1 and 30.1 % respectively...
  27. doi Changes in expression of cell-cycle-related genes in PC-3 prostate cancer cells caused by ovine uterine serpin
    Maria B Padua
    Department of Animal Sciences, University of Florida, Gainesville, Florida 32611 0910, USA
    J Cell Biochem 107:1182-8. 2009
    ..24 h, rOvUS decreased expression of 16 genes related to regulation and progression through M (BIRC5, CCNB1, CKS2, CDK5RAP1, CDC20, E2F4, MAD2L2) and G(1) (CDK4, CDKN3, TFDP2), DNA damage checkpoints and repair (RAD17, BRCA1, BCCIP, ..
  28. doi Targeting of prostate cancer cells by a cytotoxic lentiviral vector containing a prostate stem cell antigen (PSCA) promoter
    Frank A Petrigliano
    Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Prostate 69:1422-34. 2009
    ..The purpose of this investigation was to evaluate the specificity and efficacy of a lentiviral vector driven by a PSCA promoter...
  29. doi The single NTPase gene of Drosophila melanogaster encodes an intracellular nucleoside triphosphate diphosphohydrolase 6 (NTPDase6)
    Aileen F Knowles
    Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, California 92182 1030, USA
    Arch Biochem Biophys 484:70-9. 2009
    ..Mutagenesis studies indicated that dimer formation required C42 in the transmembrane domain and C447 in the exoplasmic domain...
  30. doi Large-conductance channel formation mediated by P2X7 receptor activation is regulated through distinct intracellular signaling pathways in peritoneal macrophages and 2BH4 cells
    R X Faria
    Laboratory of Cellular Communication, Department of Immunology, Oswaldo Cruz Institute, FIOCRUZ Oswaldo Cruz Foundation, Av Brazil, 4365, Manguinhos, Rio de Janeiro 21045 900, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 382:73-87. 2010
    ..Am J Physiol Cell Physiol 297:C28-C42, 2005)...
  31. doi Production of medium-chain triacylglycerols from corn oil: optimization by response surface methodology
    Tarik Oztürk
    Istanbul Technical University, Institute of Science and Technology, Istanbul, Turkey
    Bioresour Technol 101:7456-61. 2010
    ..caprylic acid containing SLs was obtained. This product was characterized by 50% of triacylglycerol species with equivalent carbon number (ECN) C30, C32, C36, and C38, and 50% of triacylglycerol species with ECN C42, C44, and C46.
  32. doi Intermediate monomer-dimer equilibrium structure of native ICAM-1: implication for enhanced cell adhesion
    Hyun Mee Oh
    School of Life Sciences, and Immune Synapse Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
    Exp Cell Res 317:163-72. 2011
    ..1) the binding degree of monomer-specific antibody CA-7 and 2) the ratio of dimer/monomer when a mutation (L42→C42) was introduced in the interface of domain 1...
  33. doi Identification of multiple folding pathways of monellin using pulsed thiol labeling and mass spectrometry
    Santosh Kumar Jha
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    Biochemistry 50:3062-74. 2011
    ..The kinetics of burial of the C42 thiol of monellin was observed to follow biexponential kinetics...
  34. ncbi PARP and RIP 1 are required for autophagy induced by 11'-deoxyverticillin A, which precedes caspase-dependent apoptosis
    Nan Zhang
    National Research Center of Urological Cancer, Institute of Urology, Peking University First Hospital, Beijing, China
    Autophagy 7:598-612. 2011
    ..In the current work, we found that 11'-deoxyverticillin A (C42), a member of the ETPs, induces autophagosome formation, accumulation of microtubule-associated protein 1 light ..
  35. pmc Draft genome sequence of the marine Streptomyces sp. strain PP-C42, isolated from the Baltic Sea
    Longjiang Fan
    James D Watson Institute of Genome Sciences and Institute of Crop Science, Zhejiang University, Hangzhou 310029, China
    J Bacteriol 193:3691-2. 2011
    ..Here we report the draft genome sequence of a Streptomyces strain, PP-C42, isolated from the marine environment...
  36. ncbi Reducing sugar-producing bacteria from guts of Tenebrio molitor Linnaeus (yellow mealworm) for lignocellulosic waste minimization
    Wei Qi
    School of Civil and Environmental Engineering, Nanyang Technological University, Singapore
    Microbes Environ 26:354-9. 2011
    ..The maximum reducing sugars yield by the combination of Agromyces sp. C42 and Stenotrophomonas sp. A10b was 56...
  37. ncbi A mutant streptokinase lacking the C-terminal 42 amino acids is less reactive with preexisting antibodies in patient sera
    I Torrens
    Division of Pharmaceutical, Centro de Ingenieria Genetica y Biotecnologia, Havana, Cuba
    Biochem Biophys Res Commun 266:230-6. 1999
    ..An SKC-2 deletion mutant (mut-C42), lacking the same 42 C-terminal residues, was constructed and expressed in Escherichia coli...
  38. pmc The C-terminal 42 residues of the Tula virus Gn protein regulate interferon induction
    Valery Matthys
    Department of Molecular Genetics and Microbiology, Stony Brook University, Life Sciences Room 126, Stony Brook, NY 11794 5222, USA
    J Virol 85:4752-60. 2011
    ..Analysis of Gn-T truncations demonstrated that the C-terminal 42 residues of the Gn-T (Gn-T-C42) from TULV, but not PHV, inhibited IFN induction >70%...
  39. doi Fingerprinting and source identification of an oil spill in China Bohai Sea by gas chromatography-flame ionization detection and gas chromatography-mass spectrometry coupled with multi-statistical analyses
    Peiyan Sun
    Key Laboratory of Marine Spill Oil Identification and Damage Assessment Technology, SOA, Qingdao 266033, China
    J Chromatogr A 1216:830-6. 2009
    ..profiles of the three spilled oil samples are positive match with that of the suspected source oil samples C41, C42, C43, C44 and C45; (4) There are significant differences in the oil fingerprinting profiles between the three ..
  40. doi Grape and wine polyphenols down-regulate the expression of signal transduction genes and inhibit the growth of estrogen receptor-negative MDA-MB231 tumors in nu/nu mouse xenografts
    Fatima Hakimuddin
    Department of Food Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Nutr Res 28:702-13. 2008
    ..Several genes related to cell cycle regulation, such as CDK5RAP1, RBBP8, and SERTAD1, were up-regulated in these tumors...
  41. ncbi Cuticular lipids of the booklouse, Liposcelis bostrychophila: hydrocarbons, aldehydes, fatty acids, and fatty acid amides
    Ralph W Howard
    USDA ARS, GMPRC, 1515 College Avenue, Manhattan, KS 66502, USA
    J Chem Ecol 29:615-27. 2003
    ..C21-C34), monomethyl alkanes (3-, 4-, 5-, 7-, 9-, 11-, 12-, 13- and 15-methyl-) with a carbon chain range of C28-C42, and dimethyl alkanes (3, 7-; 9, 13-; 11, 15-; 13, 17-; 9, 21-; 11, 19-; and 13, 21-) with a carbon number range of ..
  42. ncbi Different conformational forms of Escherichia coli and rat liver 5S rRNA revealed by Pb(II)-induced hydrolysis
    J Ciesiołlka
    Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan
    Eur J Biochem 204:583-9. 1992
    ..presence of two strong helical domains; helix A retained from the A form and a helix composed of RNA regions G33-C42 and G79-C88...
  43. ncbi [Activation of ATP-sensitive K+ channels by ADP and K+ channel openers: homology model of sulfonylurea receptor carboxyl-termini]
    A Fujita
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nihon Yakurigaku Zasshi 118:177-86. 2001
    ..SUR2A and SUR2B are splice variants and differ only in the C-terminal 42 amino acid residue (C42)...
  44. pmc Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines
    D A Tonetti
    Robert H Lurie Comprehensive Cancer Centre, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    Br J Cancer 83:782-91. 2000
    ..the expression of PKC isozymes in the hormone-independent human breast cancer cell clones MCF-7 5C and T47D:C42 compared with their hormone-dependent counterparts, MCF-7 A4, MCF-7 WS8 and T47D:A18 respectively...
  45. ncbi Identification of a common protein association region in the neuronal Cdk5 activator
    X Wang
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Peoples Republic of China
    J Biol Chem 275:31763-9. 2000
    ..cellular proteins have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and C53 found by a yeast two-hybrid screen (Ching, Y. P., Qi, Z., and Wang, J. H. (2000) Gene 242, 285-294)...
  46. ncbi A mutant streptokinase lacking the C-terminal 42 amino acids is less immunogenic
    I Torrens
    Division of Pharmaceutical, Centro de Ingenieria Genetica y Biotecnologia, Havana, Cuba
    Immunol Lett 70:213-8. 1999
    ..In previous in vitro studies, we have shown that a deletion mutant (mut-C42), lacking the 42 C-terminal residues, was significantly less antigenic when compared with the native molecule (SKC-..
  47. ncbi Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9
    S Ikegawa
    Laboratory of Genome Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    Cytogenet Cell Genet 85:227-31. 1999
    ..C8orf2 also bore sequence homology to the human KE04p gene. Its conservation among highly divergent species suggests that C8orf2 belongs to a novel gene family...
  48. ncbi Differential roles for disulfide bonds in the structural integrity and biological activity of kappa-Bungarotoxin, a neuronal nicotinic acetylcholine receptor antagonist
    G A Grant
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 37:12166-71. 1998
    ..In fact, when either C3-C21 or C14-C42 are removed individually, no loss in biological activity is seen...
  49. ncbi Tertiary and quaternary structures of 0.19 alpha-amylase inhibitor from wheat kernel determined by X-ray analysis at 2.06 A resolution
    Y Oda
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560, Japan
    Biochemistry 36:13503-11. 1997
    ..All 10 cysteine residues in 0.19 AI form disulfide bonds (C6-C52, C20-C41, C28-C83, C42-C99, and C54-C115), consistent with the assignments made biochemically for 0...
  50. pmc Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin
    D P Meininger
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla 92093 0601, USA
    Protein Sci 4:1683-95. 1995
    ..the disulfide bond between C372 and C386 in TM4 is five amino acids longer than the analogous loop between C33 and C42 of EGF protein. This loop appears to have a different fold in TM4 than in EGF protein...
  51. ncbi Studies on the formation of a unique cellular intermediate (EAC14256) from EAC142 and C56
    H Kitamura
    Department of Immunology, Center for Adult Diseases, Osaka, Japan
    Int Arch Allergy Appl Immunol 85:322-8. 1988
    ..the medium and thus the reaction between C56 and EAC142 is reversible; (4) the receptor on EAC142 for C56 is C2 or C42 on the cell surface, and (5) the binding of C56 to C2 or C42 on cells is independent of the usual (C3-dependent) ..
  52. ncbi Analysis of the in vivo phosphorylation state of rabbit skeletal muscle glycogen synthase by fast-atom-bombardment mass spectrometry
    L Poulter
    Department of Chemistry, University of Cambridge
    Eur J Biochem 175:497-510. 1988
    ..N) and C-terminal (C) cyanogen bromide peptides were identified as the serine residues at N7, the region C28-C39, C42, C46 and C100. In animals injected with adrenalin, the phosphorylation of N7 increased from 0.6 to 0...
  53. ncbi A new stereoselective synthesis of ciguatoxin right wing fragments
    Masayuki Inoue
    Department of Chemistry, Graduate School of Science, Tohoku University, Aramaki, Aoba ku, Sendai 980 8578, Japan
    J Org Chem 69:2797-804. 2004
    ..olefination to cyclize the J ring, (iii) regio- and stereoselective reduction of the epoxyacetal to install the C42-stereocenter, and (iv) stereoselective reductive etherification to construct the K ring...
  54. ncbi Acute panmyelosis with myelofibrosis: clinical, immunophenotypic and cytogenetic study of twelve cases
    N Suvajdzic
    Institute of Hematology, Clinical Center of Serbia, Belgrade, Union of Serbia and Montenegro
    Leuk Lymphoma 45:1873-9. 2004
    ..immunophenotypic features in 12 adult patients with acute panmyelosis with myelofibrosis (APMF; ICD-0-3: 9931/3; C42.1) are reported (median age: 57 years; f/m = 1.4)...
  55. pmc Secondary metabolites produced by the marine bacterium Halobacillus salinus that inhibit quorum sensing-controlled phenotypes in gram-negative bacteria
    Margaret E Teasdale
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, 02881, USA
    Appl Environ Microbiol 75:567-72. 2009
    ..Isolate C42, a Halobacillus salinus strain obtained from a sea grass sample, inhibits bioluminescence production by Vibrio ..
  56. pmc Autographa californica multiple nucleopolyhedrovirus 38K is a novel nucleocapsid protein that interacts with VP1054, VP39, VP80, and itself
    Wenbi Wu
    State Key Laboratory of Biocontrol, Sun Yat Sen University, Guangzhou 510275, China
    J Virol 82:12356-64. 2008
    ..between 38K and nine known nucleocapsid shell-associated proteins (PP78/83, PCNA, VP1054, FP25, VLF-1, VP39, BV/ODV-C42, VP80, and P24), three non-nucleocapsid shell-associated proteins (P6.9, PP31, and BV/ODV-E26), and itself...
  57. doi How does plasmid DNA penetrate cell membranes in artificial transformation process of Escherichia coli?
    Subrata Panja
    Department of Biochemistry and Biophysics, University of Kalyani, West Bengal, India
    Mol Membr Biol 25:411-22. 2008
    ..trimethyl ammonium diphenyl hexatriene (TMA-DPH), bound to cellular outer membrane, indicated heat-pulse (0 degrees C42 degrees C) step of the standard transformation procedure had lowered considerably outer membrane fluidity of cells...
  58. doi Identification of AcMNPV EXON0 (ac141) domains required for efficient production of budded virus, dimerization and association with BV/ODV-C42 and FP25
    Minggang Fang
    Plant Science, Faculty of Land and Food Systems, University of British Columbia, Vancouver, B C, Canada V6T 1Z4
    Virology 375:265-76. 2008
    ..EXON0 interacts with nucleopcapsid protein BV/ODV-C42 and FP25 and enables egress of nucleocapsids from the nucleus to the cytoplasm...
  59. pmc Autographa californica multiple nucleopolyhedrovirus nucleocapsid protein BV/ODV-C42 mediates the nuclear entry of P78/83
    Yun Wang
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People s Republic of China
    J Virol 82:4554-61. 2008
    Autographa californica multiple nucleopolyhedrovirus (AcMNPV) BV/ODV-c42 (orf101; c42), which encodes a 41...
  60. ncbi Insights into the structural variation between pentapeptide repeat proteins--crystal structure of Rfr23 from Cyanothece 51142
    Garry W Buchko
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    J Struct Biol 162:184-92. 2008
    ..Third, a disulfide bond between C39 and C42 bridges the beta-turn between the first and second pentapeptide repeats in the first coil (disulfide bracket)...
  61. pmc Autographa californica multiple nucleopolyhedrovirus EXON0 (ORF141) is required for efficient egress of nucleocapsids from the nucleus
    Minggang Fang
    Pacific Agri Food Research Centre, Agriculture and Agri Food Canada, Box 5000, Summerland, BC, Canada
    J Virol 81:9859-69. 2007
    ..and confocal microscopy revealed that it interacted with nucleocapsid proteins FP25 and BV/ODV-C42. Cells transfected with the exon0 KO virus exhibited normally appearing nucleocapsids in the nuclei in numbers ..
  62. ncbi Sphingomonas astaxanthinifaciens sp. nov., a novel astaxanthin-producing bacterium of the family Sphingomonadaceae isolated from Misasa, Tottori, Japan
    Dalal Asker
    Life Science Research Center, College of Bioresource Sciences, Nihon University, Fujisawa, Japan
    FEMS Microbiol Lett 273:140-8. 2007
    ..0%), Sphingomonas asaccharolytica IFO 15499(T) (93.9%) and Sphingomonas abaci C42(T) (93.9%). The major fatty acids were C(17 : 1)omega6c (33.0%) and C(18 : 1)omega7c (20.8%)...
  63. pmc Proteomics analysis of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus identified two new occlusion-derived virus-associated proteins, HA44 and HA100
    Fei Deng
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People s Republic of China
    J Virol 81:9377-85. 2007
    ..9, ODV/BV-C42, VP80, ODV-EC43, ODV-E66, and PIF-1...
  64. ncbi Total synthesis of phorboxazole A. 2. Assembly of subunits and completion of the synthesis
    James D White
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA
    Org Lett 8:6043-6. 2006
    Structure: see text] Subunits of phorboxazole A containing C1-C2, C3-C8, C9-C19, C20-C32, C33-C41, and C42-C46 were connected in a sequence that first linked C32 with C33 and then C41 with C42...
  65. ncbi Trends in incidence of childhood leukemia, Khon Kaen, Thailand, 1985-2002
    Supot Kamsa-Ard
    Faculty of Public Health, Khon Kaen University, Khon Kaen, 40002, Thailand
    Asian Pac J Cancer Prev 7:75-8. 2006
    ..Leukemia is the most common cancer among Thai children in Thailand, including both curable and preventable types, but no assessment of trends has hitherto been performed...
  66. pmc Studies of stereocontrolled allylation reactions for the total synthesis of phorboxazole A
    David R Williams
    Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405 7102, USA
    Proc Natl Acad Sci U S A 101:12058-63. 2004
    ..The synthesis culminates with use of a modified Julia olefination for attachment of the C42-C46 segment and subsequent late-stage macrocyclization by installation of the (Z)-C2/C3 alpha,beta-unsaturated ..
  67. ncbi Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA
    W Dai
    Hipple Cancer Research Center, Dayton, Ohio 45439
    Biochem Biophys Res Commun 168:1-8. 1990
    ..A cDNA clone (called C42) was isolated from a cDNA library made from poly(A)+ RNA obtained from HuIFN-gamma-treated human fibroblasts...

Research Grants45

  1. Role of Raf Kinase Inhibitory Protein in Prostate Cancer
    Marsha Rosner; Fiscal Year: 2009
    ..ectopic expression of RKIP suppressed invasion in vitro and metastasis in vivo in the well-characterized metastatic C42 human prostate cancer cell model...
  2. Role of Raf Kinase Inhibitory Protein in Prostate Cancer
    Marsha Rosner; Fiscal Year: 2007
    ..ectopic expression of RKIP suppressed invasion in vitro and metastasis in vivo in the well-characterized metastatic C42 human prostate cancer cell model...
  3. INTERESTING BIOACTIVE SUBSTANCES
    David Williams; Fiscal Year: 2002
    ..A particularly rich spectrum of biological activity, including important anti-tumor activity, is exhibited throughout this class of novel medium-ring metabolites. ..
  4. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2004
    ..The intramolecular (4+2) cycloadditions of nitroalkene precursors will provide facile construction of trans-decalins. . ..
  5. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2009
    ..Daphnicyclidin A. This recent discovery has revealed a new molecular architecture which exhibits significant antitumor activity. Our research will investigate strategies for chemical synthesis of these complex polycyclic systems. ..
  6. INTERESTING BIOACTIVE SUBSTANCES
    David Williams; Fiscal Year: 2006
    ..The selective synthesis of contiguous stereotriads will advance basic methodology for asymmetric conjugate additions. ..
  7. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2009
    ..Daphnicyclidin A. This recent discovery has revealed a new molecular architecture which exhibits significant antitumor activity. Our research will investigate strategies for chemical synthesis of these complex polycyclic systems. ..
  8. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2000
    ..These macrocyclic antitumor agents exhibit important antibiotic effects against resistant organisms. New strategies for macrocyclization are introduced. Acyl nitrene insertions for preparation of lankacyclinol are described. ..
  9. INVESTIGATIONS OF INTERESTING BIOACTIVE SUBSTANCES
    David Williams; Fiscal Year: 1993
    ..Finally, we have outlined explorations of fundamental heterocyclic oxazole chemistry as a precursor to our plans for total synthesis of the ulapualides, extraordinarily potent and unique antitumor marine natural products...
  10. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 1992
    ..They also show strong atimicrobial activities, principally against Gram-positive bacteria, including some strains of clinically resistant isolates...
  11. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 1993
    ..Secondly, studies of the Michael reaction will be explored for ring annulation. Finally, new methodology for carbanions in nitrogen-containing, chiral synthons will be detailed...