Cdk5

Summary

Gene Symbol: Cdk5
Description: cyclin dependent kinase 5
Alias: LIS7, PSSALRE, cyclin-dependent-like kinase 5, TPKII catalytic subunit, cell division protein kinase 5, protein kinase CDK5 splicing, serine/threonine-protein kinase PSSALRE, tau protein kinase II catalytic subunit
Species: human
Products:     Cdk5

Top Publications

  1. Michel G, Mercken M, Murayama M, Noguchi K, Ishiguro K, Imahori K, et al. Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells. Biochim Biophys Acta. 1998;1380:177-82 pubmed
    ..Combined tau protein kinase II (TPK II), which consists of CDK5 and its activator (p23), and glycogen synthase kinase-3beta (GSK-3beta) phosphorylate tau to the PHF-form in vitro...
  2. Liebl J, Fürst R, Vollmar A, Zahler S. Twice switched at birth: cell cycle-independent roles of the "neuron-specific" cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells. Cell Signal. 2011;23:1698-707 pubmed publisher
    b>Cdk5 (cyclin-dependent kinase 5 or initially NCLK for neuronal CDC2-like kinase) was switched twice at its birth nearly twenty years ago: first it was thought to be cyclin-dependent, second it was assumed to be primarily of importance in ..
  3. Tanaka T, Serneo F, Tseng H, Kulkarni A, Tsai L, Gleeson J. Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration. Neuron. 2004;41:215-27 pubmed
    Mutations in the doublecortin (DCX) gene in human or targeted disruption of the cdk5 gene in mouse lead to similar cortical lamination defects in the developing brain. Here we show that Dcx is phosphorylated by Cdk5...
  4. Liebl J, Weitensteiner S, Vereb G, Takacs L, Fürst R, Vollmar A, et al. Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis. J Biol Chem. 2010;285:35932-43 pubmed publisher
    ..Here we show that cyclin-dependent kinase 5 (Cdk5), an important modulator of neuronal processes, regulates endothelial cell migration and angiogenesis, suggesting ..
  5. Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, et al. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. 2003;38:555-65 pubmed
    ..To examine the impact of cdk5 in tau aggregation and tangle formation, we crossed transgenic mice overexpressing the cdk5 activator p25, with ..
  6. Gong X, Tang X, Wiedmann M, Wang X, Peng J, Zheng D, et al. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron. 2003;38:33-46 pubmed
    Neurotoxic insults deregulate Cdk5 activity, which leads to neuronal apoptosis and may contribute to neurodegeneration. The biological activity of Cdk5 has been ascribed to its phosphorylation of cytoplasmic substrates...
  7. Lowman X, McDonnell M, Kosloske A, Odumade O, Jenness C, Karim C, et al. The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose. Mol Cell. 2010;40:823-33 pubmed publisher
    ..Phosphorylation promotes its cytosolic sequestration and suppresses its apoptotic function. We identify Cdk5 as the Noxa kinase and show that Cdk5 knockdown or expression of a Noxa S(13) to A mutant increases sensitivity to ..
  8. Li B, Zhang L, Takahashi S, Ma W, Jaffe H, Kulkarni A, et al. Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J. 2002;21:324-33 pubmed
    Cyclin-dependent kinase 5 (cdk5) is a serine/threonine kinase activated by associating with its neuron-specific activators p35 and p39...
  9. Fu W, Cheng K, Fu A, Ip N. Cyclin-dependent kinase 5-dependent phosphorylation of Pctaire1 regulates dendrite development. Neuroscience. 2011;180:353-9 pubmed publisher
    ..regulates neurotransmitter release through phosphorylation of NSF, and its kinase activity is regulated by the Cdk5-dependent phosphorylation at Serine-95 (Ser95)...

More Information

Publications71

  1. Rashid T, Banerjee M, Nikolic M. Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology. J Biol Chem. 2001;276:49043-52 pubmed
    The small GTPase Rac and its effectors, the Pak1 and p35/Cdk5 kinases, have been assigned important roles in regulating cytoskeletal dynamics in neurons...
  2. Humbert S, Dhavan R, Tsai L. p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. J Cell Sci. 2000;113 ( Pt 6):975-83 pubmed
    Cyclin-dependent kinase 5 (cdk5) is a small serine/threonine kinase that displays close sequence homology to the mitotically active cyclin-dependent kinases...
  3. Fu X, Choi Y, Qu D, Yu Y, Cheung N, Qi R. Identification of nuclear import mechanisms for the neuronal Cdk5 activator. J Biol Chem. 2006;281:39014-21 pubmed
    The activation of Cdk5 by p35 plays a pivotal role in a multitude of nervous system activities ranging from neuronal differentiation to degeneration...
  4. Hou Z, Li Q, He L, Lim H, Fu X, Cheung N, et al. Microtubule association of the neuronal p35 activator of Cdk5. J Biol Chem. 2007;282:18666-70 pubmed
    b>Cdk5 and its neuronal activator p35 play an important role in neuronal migration and proper development of the brain cortex. We show that p35 binds directly to alpha/beta-tubulin and microtubules...
  5. Kanaoka Y, Kimura S, Okazaki I, Ikeda M, Nojima H. GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain. FEBS Lett. 1997;402:73-80 pubmed
    ..GAK also co-precipitated with CDK5, and CDK5 was found to be associated with cyclin G...
  6. Hsu F, Chen M, Lin K, Peng Y, Li P, Lin E, et al. Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser?²? on STAT3 in prostate cancer cells. Am J Physiol Endocrinol Metab. 2013;305:E975-86 pubmed publisher
    Cyclin-dependent kinase 5 (Cdk5) is known to regulate prostate cancer metastasis. Our previous results indicated that Cdk5 activates androgen receptor (AR) and supports prostate cancer growth...
  7. Liu J, Wang X, Huang B, Zhu F, Zhang R, Wu G. Expression of CDK5/p35 in resected patients with non-small cell lung cancer: relation to prognosis. Med Oncol. 2011;28:673-8 pubmed publisher
    ..Recently, several studies demonstrated that cyclin-dependent kinase-5 (CDK5) activity with its specific activator protein p35 was important for spontaneous metastasis in various types of ..
  8. Arias Vasquez A, Aulchenko Y, Isaacs A, van Oosterhout A, Sleegers K, Hofman A, et al. Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study. J Neurol. 2008;255:655-62 pubmed publisher
    Although the role of the Cdk5 protein in Alzheimer's disease (AD) is well recognized, there have been relatively few studies investigating genetic variants in the CDK5 gene in AD...
  9. Rademakers R, Sleegers K, Theuns J, Van den Broeck M, Bel Kacem S, Nilsson L, et al. Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. Neurobiol Aging. 2005;26:1145-51 pubmed
    Malfunctioning of cyclin-dependent kinase 5 (CDK5) through aberrant proteolytic cleavage of its neuronal activators p35 and p39 is involved in neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative brain diseases...
  10. Ajay A, Upadhyay A, Singh S, Vijayakumar M, Kumari R, Pandey V, et al. Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression. Mol Cancer. 2010;9:204 pubmed publisher
    ..Several stress activated kinases are known to phosphorylate p53 and, among them cyclin dependent kinase 5 (Cdk5) is one of the kinase studied in neuronal cell system...
  11. Lin H, Chen M, Chiu C, Song Y, Lin S. Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells. J Biol Chem. 2007;282:2776-84 pubmed
    ..Amyloid aggregation in neurodegeneration leads to hyperactivation of Cdk5 and subsequent neuronal death...
  12. Choi J, Banks A, Estall J, Kajimura S, Boström P, Laznik D, et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature. 2010;466:451-6 pubmed publisher
    Obesity induced in mice by high-fat feeding activates the protein kinase Cdk5 (cyclin-dependent kinase 5) in adipose tissues...
  13. Peterson D, Ando D, Taketa D, Zhou H, Dahlquist F, Lew J. No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro. Proc Natl Acad Sci U S A. 2010;107:2884-9 pubmed publisher
    b>CDK5/p35 is a cyclin-dependent kinase essential for normal neuron function. Proteolysis of the p35 subunit in vivo results in CDK5/p25 that causes neurotoxicity associated with a number of neurodegenerative diseases...
  14. Liu R, Tian B, Gearing M, Hunter S, Ye K, Mao Z. Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion. Proc Natl Acad Sci U S A. 2008;105:7570-5 pubmed publisher
    ..Here, we demonstrate that cyclin dependent kinase 5 (Cdk5), a protein known to function mainly in postmitotic neurons, directly phosphorylates PIKE-A at Ser-279 in its ..
  15. Chen F, Studzinski G. Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation. Blood. 2001;97:3763-7 pubmed
    Although cyclin-dependent kinase 5 (Cdk5) is widely expressed in human tissues, its activator p35Nck5a is generally considered to be neuron specific...
  16. Tripathi B, Zelenka P. Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP. Mol Cell Biol. 2009;29:6488-99 pubmed publisher
    b>Cdk5 regulates adhesion and migration in a variety of cell types. We previously showed that Cdk5 is strongly activated during stress fiber formation and contraction in spreading cells...
  17. Patrick G, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai L. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature. 1999;402:615-22 pubmed
    Cyclin-dependent kinase 5 (Cdk5) is required for proper development of the mammalian central nervous system. To be activated, Cdk5 has to associate with its regulatory subunit, p35...
  18. Eggers J, Grandgenett P, Collisson E, Lewallen M, Tremayne J, Singh P, et al. Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras. Clin Cancer Res. 2011;17:6140-50 pubmed publisher
    To evaluate the nature of cyclin-dependent kinase 5 (CDK5) hyperactivity in pancreatic cancer progression...
  19. Choi H, Lee Y, Park K, Sung J, Lee J, Shin E, et al. Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population. J Hum Genet. 2009;54:298-303 pubmed publisher
    Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine kinase, which was originally known for its regulatory role in neuronal activities, has recently been suggested to play a role in extraneuronal activities...
  20. Demelash A, Rudrabhatla P, Pant H, Wang X, Amin N, McWhite C, et al. Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway. Mol Biol Cell. 2012;23:2856-66 pubmed publisher
    ..In the CNS, cyclin-dependent kinase 5 (Cdk5) and its activator p35 are important for neuronal migration that is regulated by basic helix-loop-helix ..
  21. Tsai L, Delalle I, Caviness V, Chae T, Harlow E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature. 1994;371:419-23 pubmed
    Cyclin-dependent kinase 5 (Cdk5) was originally isolated through its structural homology to human Cdc2, a key regulator of cell-cycle progression...
  22. Ino H, Ishizuka T, Chiba T, Tatibana M. Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems. Brain Res. 1994;661:196-206 pubmed
    b>CDK5 is a cdc2-related protein kinase that is known to be highly expressed in mature brain. In this study, we obtained a mouse CDK5 cDNA by screening an adult mouse cDNA library...
  23. Kuo H, Hsu F, Chiang M, You S, Chen M, Lo M, et al. The role of Cdk5 in retinoic acid-induced apoptosis of cervical cancer cell line. Chin J Physiol. 2009;52:23-30 pubmed
    b>Cdk5 is a small serine/threonine protein kinase which belongs to Cdk family. Unlike other Cdk members, so far Cdk5 is known to be irrelevant in cell cycle. Cdk5 kinase activity is regulated by binding with its activator, p35...
  24. Chang K, de Pablo Y, Lee H, Lee H, Smith M, Shah K. Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease. J Neurochem. 2010;113:1221-9 pubmed publisher
    ..Both p38 and Cdk5 promote neurodegeneration upon deregulation...
  25. Hisanaga S, Endo R. Regulation and role of cyclin-dependent kinase activity in neuronal survival and death. J Neurochem. 2010;115:1309-21 pubmed publisher
    ..Kinase activity is also regulated by Cdk5 phosphorylation, but the activity of phosphorylated Cdk5 is in contrast to that of cycling Cdks...
  26. Zhang J, Herrup K. Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. Cell Cycle. 2011;10:1208-14 pubmed
    ..One possible link is the atypical cyclin dependent kinase, Cdk5. Cdk5 exerts a double protective function in neurons, first by suppressing the cell cycle in the nucleus and second ..
  27. Contreras Vallejos E, Utreras E, Gonzalez Billault C. Going out of the brain: non-nervous system physiological and pathological functions of Cdk5. Cell Signal. 2012;24:44-52 pubmed publisher
    Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is mostly active in the nervous system, where it regulates several processes such as neuronal migration, actin and microtubule dynamics, axonal guidance, ..
  28. Pozo K, Castro Rivera E, Tan C, Plattner F, Schwach G, Siegl V, et al. The role of Cdk5 in neuroendocrine thyroid cancer. Cancer Cell. 2013;24:499-511 pubmed publisher
    ..We found that Cdk5 and its cofactors p35 and p25 are highly expressed in human MTC and that Cdk5 activity promotes MTC proliferation...
  29. Lew J, Huang Q, Qi Z, Winkfein R, Aebersold R, Hunt T, et al. A brain-specific activator of cyclin-dependent kinase 5. Nature. 1994;371:423-6 pubmed
    ..The purified enzyme is a heterodimer of cyclin-dependent kinase 5 (Cdk5) and a novel regulatory subunit, p25 (ref. 8)...
  30. Seo H, Kim J, Bae S, Soh J, Lee Y. Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1. J Biol Chem. 2008;283:15601-10 pubmed publisher
    ..In addition, the kinase activity of Cdk5 was increased by cyclin G1 overexpression, and Cdk5 directly phosphorylated c-Myc on Ser-62...
  31. Lee J, Kim H, Lee S, Kim K. Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J Cell Sci. 2007;120:2259-71 pubmed
    ..Cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, is most active in the central nervous system and plays a variety of ..
  32. Mitsios N, Pennucci R, Krupinski J, Sanfeliu C, Gaffney J, Kumar P, et al. Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke. Brain Pathol. 2007;17:11-23 pubmed
    Neuronal cell death after brain ischemia may be regulated by activation of cyclin-dependent kinase 5 (Cdk5)...
  33. Avraham E, Rott R, Liani E, Szargel R, Engelender S. Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation. J Biol Chem. 2007;282:12842-50 pubmed
    ..We now report that cyclin-dependent kinase 5 (Cdk5) phosphorylates Parkin both in vitro and in vivo...
  34. Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg M. Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat Cell Biol. 2009;11:624-30 pubmed publisher
    ..We found that talin head is a substrate for Cdk5, a cyclin-dependent protein kinase that is essential for cell migration, synaptic transmission and cancer ..
  35. Zukerberg L, Patrick G, Nikolic M, Humbert S, Wu C, Lanier L, et al. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron. 2000;26:633-46 pubmed
    Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates...
  36. Sharma P, Veeranna -, Sharma M, Amin N, Sihag R, Grant P, et al. Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. J Biol Chem. 2002;277:528-34 pubmed
    Cyclin-dependent protein kinase 5 (cdk5), a member of the cdk family, is active mainly in postmitotic cells and plays important roles in neuronal development and migration, neurite outgrowth, and synaptic transmission...
  37. Lee J, Jeong M, Kim W, Choi Y, Kim K. Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress. J Biol Chem. 2008;283:19826-35 pubmed publisher
    ..c-Abl mediates down-regulation of HDM2, leading to an increase of p53 level. Moreover, Cdk5 (cyclin-dependent kinase 5), a proline-directed Ser/Thr kinase, additionally increases p53 stability via post-..
  38. Liang Q, Li L, Zhang J, Lei Y, Wang L, Liu D, et al. CDK5 is essential for TGF-?1-induced epithelial-mesenchymal transition and breast cancer progression. Sci Rep. 2013;3:2932 pubmed publisher
    ..b>CDK5 is a proline-directed serine/threonine kinase playing important roles in cancer progression...
  39. Guidato S, McLoughlin D, Grierson A, Miller C. Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity. J Neurochem. 1998;70:335-40 pubmed
    ..As cyclin D2 and cdk-5 are known to share overlapping patterns of expression during development of the CNS, the results presented here suggest a role for cyclin D2 in modulating cdk-5 activity in postmitotic developing neurones. ..
  40. Meyerson M, Enders G, Wu C, Su L, Gorka C, Nelson C, et al. A family of human cdc2-related protein kinases. EMBO J. 1992;11:2909-17 pubmed
    ..The identification of a large family of cdc2-related kinases opens the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins. ..
  41. Hsu F, Chen M, Chiang M, Lin E, Lee Y, Huang P, et al. Regulation of androgen receptor and prostate cancer growth by cyclin-dependent kinase 5. J Biol Chem. 2011;286:33141-9 pubmed publisher
    ..Recently, the roles of cyclin-dependent kinase 5 (Cdk5) and its activator, p35, in cancer biology are explored one after another...
  42. Lopes J, Agostinho P. Cdk5: multitasking between physiological and pathological conditions. Prog Neurobiol. 2011;94:49-63 pubmed publisher
    Cyclin-dependent kinase 5 (Cdk5) is a peculiar proline-directed serine/threonine kinase...
  43. Niethammer M, Smith D, Ayala R, Peng J, Ko J, Lee M, et al. NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron. 2000;28:697-711 pubmed
    ..Furthermore, NUDEL is a substrate of Cdk5, a kinase known to be critical during neuronal migration...
  44. Lin H, Juang J, Wang P. Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. J Biol Chem. 2004;279:29302-7 pubmed
    ..be targets of intracellular Ca(2+), and subsequently correlated to apoptosis, we not only demonstrated first that Cdk5, p35, and p25 proteins were all expressed in prostate cancer cells (including lymph node carcinoma of the prostate (..
  45. Courapied S, Sellier H, de Carné Trécesson S, Vigneron A, Bernard A, Gamelin E, et al. The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition. J Biol Chem. 2010;285:26765-78 pubmed publisher
    ..We also show that topoisomerase I inhibition induced the up-regulation of the cdk5 kinase, a protein initially described in neuronal stress responses...
  46. Chien M, Chuang C, Chern C, Liou K, Liu D, Hou Y, et al. Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice. Free Radic Biol Med. 2016;99:508-519 pubmed publisher
    ..of an inflammatory transcriptional factor p65 nuclear factor-kappa B (NF-?B) and a pro-apoptotic kinase p25/Cdk5. SalA also intensively limited cortical infarction and promoted the expression of neurogenesis protein near the ..
  47. Deep A, Narasimhan B, Aggarwal S, Kaushik D, Sharma A. Thiophene Scaffold as Prospective Central Nervous System Agent: A Review. Cent Nerv Syst Agents Med Chem. 2016;16:158-64 pubmed
    ..central nervous system activity such as anticonvulsant, acetylcholinesterase inhibitor, cyclin-dependent kinase 5 (cdk5/p25) inhibitors, CNS depressant, capability to block norepinephrine, serotonin and dopamine reuptake by their ..
  48. Miller K. Keeping Neuronal Cargoes on the Right Track: New Insights into Regulators of Axonal Transport. Neuroscientist. 2016;: pubmed
    ..revealed that JIP3 promotes the clearance of organelles from axons by blocking the action of the CSS system (Cdk5, SAD Kinase, SYD-2/Liprin)...
  49. Zhu H, Xue X, Wang E, Wallack M, Na H, Hooker J, et al. Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease. Neuropharmacology. 2017;119:170-181 pubmed publisher
    ..Comparison of signaling cascades emanating from AmR suggest that amylin electively suppresses activation of the CDK5 pathway by Aβ...
  50. Illenberger S, Zheng Fischhöfer Q, Preuss U, Stamer K, Baumann K, Trinczek B, et al. The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. Mol Biol Cell. 1998;9:1495-512 pubmed
    ..Since S214 is also phosphorylated in Alzheimer's disease tau, our results support the view that reactivation of the cell cycle machinery is involved in tau hyperphosphorylation. ..
  51. Ye T, Ip J, Fu A, Ip N. Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex. Nat Commun. 2014;5:4826 pubmed publisher
    ..Importantly, activation of RapGEF2 is controlled via phosphorylation by a serine/threonine kinase Cdk5, whose activity is largely restricted to the radial migration zone...
  52. Smith Trunova S, Prithviraj R, Spurrier J, Kuzina I, Gu Q, Giniger E. Cdk5 regulates developmental remodeling of mushroom body neurons in Drosophila. Dev Dyn. 2015;244:1550-63 pubmed publisher
    ..We show here that the neuronal cyclin-dependent kinase, Cdk5, regulates the timing and rate of mushroom body remodeling: reduced Cdk5 activity causes a delay in pruning of MB ..
  53. Ceglia I, Lee K, Cahill M, Graves S, Dietz D, SURMEIER D, et al. WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine. Proc Natl Acad Sci U S A. 2017;114:1395-1400 pubmed publisher
    ..Our previous studies have found WAVE1 to be inhibited by Cdk5-mediated phosphorylation in brain and to play a role in the regulation of dendritic spine morphology...
  54. Zhang B, Su Z, Tay T, Tan V. Mechanism of CDK5 activation revealed by steered molecular dynamics simulations and energy calculations. J Mol Model. 2010;16:1159-68 pubmed publisher
    In the current work, CDK5/p25 complexes were pulled apart by applying external forces with steered molecular dynamics (SMD) simulations...
  55. Nguyen T, Grant S. Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanism. Mol Cancer Ther. 2014;13:662-74 pubmed publisher
    ..They also highlight a link between specific components of the cell-cycle regulatory apparatus (e.g., CDK1/5) and the cytoprotective IRE1/XBP-1s/Grp78 arm of the UPR that may be exploited therapeutically in UPR-driven malignancies. ..
  56. Sun S, Zhou X, Huang Y, Kong L, Mei M, Guo W, et al. Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma. Mol Cancer. 2015;14:213 pubmed publisher
    ..The cyclin-dependent kinase 5 (CDK5) is reported to contribute to cancer metastasis by regulating epithelial-mesenchymal transition (EMT)...
  57. Peruzzi F, Gordon J, Darbinian N, Amini S. Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway. J Neurovirol. 2002;8 Suppl 2:91-6 pubmed
    ..data indicate that treatment of cells with Tat severely decreases expression of p35, a neuron-specific activator of cdk5, a cyclin dependent kinase that phosphorylates several neuronal proteins including neurofilament, and plays an ..
  58. Hamdane M, Sambo A, Delobel P, Bégard S, Violleau A, Delacourte A, et al. Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex. J Biol Chem. 2003;278:34026-34 pubmed
    ..It allows investigation of tau phosphorylation by p25-Cdk5 kinase complex in a neuronal context and avoiding p25-induced cytotoxicity...
  59. Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K. GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell. 2005;120:137-49 pubmed
    ..Knockdown of CRMP-2 inhibited NT-3-induced axon outgrowth. These results suggest that NT-3 decreases phosphorylated CRMP-2 and increases nonphosphorylated active CRMP-2, thereby promoting axon outgrowth. ..
  60. Zhou X, Gu R, Han X, Wu G, Liu J. Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway. Biochem Biophys Res Commun. 2017;492:447-452 pubmed publisher
    ..However, the mechanism underlying VM needs to be elucidated. Cyclin-dependent kinase 5 (CDK5) has been recognized as a key factor in regulating migration and neuronal plasticity...
  61. Seo J, Kritskiy O, Watson L, Barker S, Dey D, Raja W, et al. Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia. J Neurosci. 2017;37:9917-9924 pubmed publisher
    ..fragment of the regulatory subunit p35, is known to induce aberrant activity of cyclin-dependent kinase 5 (Cdk5), which is associated with neurodegenerative disorders, including Alzheimer's disease...
  62. Shen J, Zhang Y, Zhao S, Mao H, Wang Z, Li H, et al. Purα Repaired Expanded Hexanucleotide GGGGCC Repeat Noncoding RNA-Caused Neuronal Toxicity in Neuro-2a Cells. Neurotox Res. 2018;33:693-701 pubmed publisher
    ..development, and the proteins' levels of microtubule-associated protein-2 (MAP2) and cyclin-dependent kinase-5 (CDK5) were used to evaluate the cell toxicity of GGGGCC repeats on Neuro-2a cells...