Gene Symbol: CDK3
Description: cyclin dependent kinase 3
Alias: cyclin-dependent kinase 3, cell division protein kinase 3
Species: human
Products:     CDK3

Top Publications

  1. Dhawan D, Hahn N, Ramos Vara J, Knapp D. Naturally-occurring canine invasive urothelial carcinoma harbors luminal and basal transcriptional subtypes found in human muscle invasive bladder cancer. PLoS Genet. 2018;14:e1007571 pubmed publisher
    ..The enriched genes included MMP9, SERPINE2, CAV1, KRT14, and RASA3 in basal tumors, and PPARG, LY6E, CTSE, CDK3, and TBX2 in luminal tumors...
  2. Taneera J, Fadista J, Ahlqvist E, Zhang M, Wierup N, Renstrom E, et al. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. Mol Cell Endocrinol. 2013;375:35-42 pubmed publisher
    ..Expression of CDKN1A, CDKN2A, CCNI2, CDK3 and CDK16 was correlated with age...
  3. Saini M, Selokar N, Revey T, Singla S, Chauhan M, Palta P, et al. Trichostatin A alters the expression of cell cycle controlling genes and microRNAs in donor cells and subsequently improves the yield and quality of cloned bovine embryos in vitro. Theriogenology. 2014;82:1036-42 pubmed publisher
    ..decreased expression of HDAC1, DNMT1, P53, CYC E1, and CDK4 and increased expression of DNMT3a, CDKN1A, CDK2, CDK3, miR-15a, miR-16, and miR-34a (P<0.05). No change in the relative expression of miR-449a was noticed...
  4. Jiménez Palomares M, López Acosta J, Villa Pérez P, Moreno Amador J, Muñoz Barrera J, Fernández Luis S, et al. Cyclin C stimulates β-cell proliferation in rat and human pancreatic β-cells. Am J Physiol Endocrinol Metab. 2015;308:E450-9 pubmed publisher
    ..Quiescent fibroblasts exit from G0 (quiescence) to G1 through pRb phosphorylation mediated by cyclin C/cdk3 complexes. Overexpression of cyclin D1, D2, D3, or cyclin E induces pancreatic β-cell proliferation...
  5. Raffel S, Trumpp A. miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells. Cancer Cell. 2016;29:133-5 pubmed publisher
    ..In this issue of Cancer Cell, Lechman and colleagues (2016) identify the microRNA miR-126 as a regulator of PI3K-AKT-mTOR and CDK3 signaling driving LSC self-renewal and chemotherapy resistance.
  6. Saraiva L, Veloso M, Camps I, da Silveira N. Structural Bioinformatics Approach of Cyclin-Dependent Kinases 1 and 3 Complexed with Inhibitors. Mol Inform. 2011;30:219-31 pubmed publisher
    ..of the CDKs, this research aimed to describe, to characterize and to compare the molecular models of CDK1 and CDK3. Since the structures of human CDK1 and CDK3 are unavailable in the Protein Data Bank -PDB, homology models were ..
  7. Zheng L, Li X, Meng X, Chou J, Hu J, Zhang F, et al. Competing endogenous RNA networks of CYP4Z1 and pseudogene CYP4Z2P confer tamoxifen resistance in breast cancer. Mol Cell Endocrinol. 2016;427:133-42 pubmed publisher
    ..we find that CYP4Z1- and CYP4Z2P-3'UTRs increase ERα activity dependent on cyclin-dependent kinase 3 (CDK3). Reporter gene and western blot assays revealed that CYP4Z1- and CYP4Z2P-3'UTRs act as CDK3 ceRNAs...
  8. Zhang Y, Yang L, Ling C, Heng W. HuR facilitates cancer stemness of lung cancer cells via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis. Biotechnol Lett. 2018;40:623-631 pubmed publisher
    ..Importantly, HuR and CDK3 expressions were increased in lung cancer tissues compared with normal adjacent tissues, and positively correlated...
  9. Hernández Ramírez L, Gam R, Valdés N, Lodish M, Pankratz N, Balsalobre A, et al. Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing's disease. Endocr Relat Cancer. 2017;24:379-392 pubmed publisher
    ..The four variants affected residues within or close to the predicted cyclin-dependent kinase-3 (CDK3)-binding region of the CABLES1 protein and impaired its ability to block cell growth in a mouse ..

More Information


  1. Khoury Haddad H, Guttmann Raviv N, Ipenberg I, Huggins D, Jeyasekharan A, Ayoub N. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc Natl Acad Sci U S A. 2014;111:E728-37 pubmed publisher
    ..Altogether, our findings implicate KDM4D in DDR, furthering the links between the cancer-relevant networks of epigenetic regulation and genome stability...
  2. Xiao T, Zhu J, Huang S, Peng C, He S, Du J, et al. Phosphorylation of NFAT3 by CDK3 induces cell transformation and promotes tumor growth in skin cancer. Oncogene. 2017;36:2835-2845 pubmed publisher
    ..Furthermore, results of the mammalian two-hybrid assay showed that cyclin-dependent kinase 3 (CDK3) directly interacted with NFAT3 and phosphorylated NFAT3 at serine 259 (Ser259), which enhanced the transactivation ..
  3. Zhang J, Li H, Zhou T, Zhou J, Herrup K. Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase. J Biol Chem. 2012;287:25985-94 pubmed publisher
    ..The data suggest an unsuspected role for Cdk5 during the progression of a normal cell cycle and offer new pharmaceutical targets for regulating neuronal cell cycling and cell death. ..
  4. Zheng D, Cho Y, Lau A, Zhang J, Ma W, Bode A, et al. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. Cancer Res. 2008;68:7650-60 pubmed publisher
    ..However, the role of cdk3 in cell proliferation, as well as cell transformation, is not yet clearly understood...
  5. Bullrich F, MacLachlan T, Sang N, Druck T, Veronese M, Allen S, et al. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. Cancer Res. 1995;55:1199-205 pubmed
    ..Here we report the chromosomal mapping of two cdks, cdk3 and cdk6, two putative cdks, PISSLRE and PITALRE, and one cyclin-dependent kinase inhibitor, p27, to chromosomal ..
  6. Sato H, Nishimoto I, Matsuoka M. ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. Biochim Biophys Acta. 2002;1574:157-63 pubmed
    A cDNA coding for ik3-2 (designated as ik3-2 from an interactor-2 with cdk3) was cloned by cross-hybridization with ik3-1 and RT-PCR...
  7. Yamochi T, Semba K, Tsuji K, Mizumoto K, Sato H, Matsuura Y, et al. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). Eur J Biochem. 2001;268:6076-82 pubmed
    ..In spite of its structural similarity to cyclins, p70ik3-1 does not activate cyclin-dependent kinase 3 (cdk3)-mediated phosphorylation of pRb, histone H1, or the C-terminal domain of RNA polymerase II...
  8. Meikrantz W, Schlegel R. Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. J Biol Chem. 1996;271:10205-9 pubmed
    ..Dominant negative mutants of CDC2, CDK2, and CDK3 each suppressed apoptosis induced by both staurosporine and tumor necrosis factor alpha, whereas a dominant ..
  9. Hofmann F, Livingston D. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. Genes Dev. 1996;10:851-61 pubmed
    The cyclin-dependent kinases cdk2 and cdk3 are required for the G1-S transition in mammalian cells...
  10. Braun K, Hölzl G, Soucek T, Geisen C, Moroy T, Hengstschlager M. Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. Oncogene. 1998;17:2259-69 pubmed
    The G1-S transition in mammalian cells has been demonstrated to require the cyclin-dependent kinases cdk2, cdk3 and cdk4/6...
  11. Lamphere L, Fiore F, Xu X, Brizuela L, Keezer S, Sardet C, et al. Interaction between Cdc37 and Cdk4 in human cells. Oncogene. 1997;14:1999-2004 pubmed
    ..Cdc37 protein specifically interacts with Cdk4 and Cdk6, but not with Cdc2, Cdk2, Cdk3, Cdk5 and any of a number of cyclins tested...
  12. Lu J, Zhang Z, Huang D, Tang N, Li Y, Peng Z, et al. Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis. Oncotarget. 2016;7:7012-28 pubmed publisher
    Cyclin dependent kinase-3 (Cdk3) is a positive regulator of the G1 mammalian cell cycle phase. Cdk3 is involved in cancer progression, but very little is known about its mechanism in cancer development and progression...
  13. Gyuris J, Golemis E, Chertkov H, Brent R. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell. 1993;75:791-803 pubmed
    ..In yeast, Cdi1 interacts with cyclin-dependent kinases, including human Cdc2, Cdk2, and Cdk3, but not with Ckd4...
  14. Cao T, Xiao T, Huang G, Xu Y, Zhu J, Wang K, et al. CDK3, target of miR-4469, suppresses breast cancer metastasis via inhibiting Wnt/?-catenin pathway. Oncotarget. 2017;8:84917-84927 pubmed publisher
    Cyclin-dependent kinase 3 (CDK3), a member of CDK family, is involved in G0/G1 and G1/S cell cycle transitions...
  15. Zheng L, Meng X, Li X, Zhang Y, Li C, Xiang C, et al. miR-125a-3p inhibits ER? transactivation and overrides tamoxifen resistance by targeting CDK3 in estrogen receptor-positive breast cancer. FASEB J. 2017;: pubmed publisher
    ..arrest at the G1/S stage, inducing apoptosis and suppressing tumor growth by targeting cyclin-dependent kinase 3 (CDK3) in vitro and in vivo In addition, CDK3 and miR-125a-3p expression levels were measured in 37 ..
  16. Zhang Z, Huang A, Zhang A, Zhou C. HuR promotes breast cancer cell proliferation and survival via binding to CDK3 mRNA. Biomed Pharmacother. 2017;91:788-795 pubmed publisher
    ..However, the detailed mechanisms remain unclear. Here we reported that overexpression of HuR increased CDK3 mRNA stability and thus its protein expression in MDA-MB-231 and MCF-7 cells...
  17. Wang L, Xi Y, Sun C, Zhang F, Jiang H, He Q, et al. CDK3 is a major target of miR-150 in cell proliferation and anti-cancer effect. Exp Mol Pathol. 2017;102:181-190 pubmed publisher
    ..molecular and cell biology techniques, we declared that miR-150 directly targets cyclin-dependent kinase 3 (CDK3) and leads to the regulation of CDK3 gene expression in both muscle-derived and non-muscle cells...
  18. Lin Z, Tan C, Qiu Q, Kong S, Yang H, Zhao F, et al. Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1. Cell Discov. 2015;1: pubmed
    ..Our study demonstrates that USP22 is a CCNB1 deubiquitinase, suggesting that targeting USP22 might be an effective approach to treat cancers with elevated CCNB1 expression. ..
  19. Connell Crowley L, Harper J, Goodrich D. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell. 1997;8:287-301 pubmed
    ..In contrast, phosphorylation of pRb by Cdk2 or Cdk3 in complexes with A- or E-type cyclins is not sufficient to inactivate pRb function in this assay, despite ..
  20. Ren S, Rollins B. Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell. 2004;117:239-51 pubmed
    ..Here we show that a non-cdk8-associated cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and that this phosphorylation is required ..
  21. Cui J, Yang Y, Li H, Leng Y, Qian K, Huang Q, et al. MiR-873 regulates ERα transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells. Oncogene. 2015;34:3895-907 pubmed publisher
    ..Reporter gene assays revealed cyclin-dependent kinase 3 (CDK3) as a direct target of miR-873...
  22. Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour M, et al. Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014;16:1080-91 pubmed publisher
    ..Cyclin C activates an 'orphan' CDK19 kinase, as well as CDK8 and CDK3. These cyclin-C-CDK complexes phosphorylate the Notch1 intracellular domain (ICN1) and promote ICN1 degradation...
  23. Zariwala M, Liu J, Xiong Y. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. Oncogene. 1998;17:2787-98 pubmed
    ..Cyclin E2 specifically interacts with CDK inhibitors of the CIP/KIP family and activates both CDK2 and CDK3. The expression of cyclin E2 mRNA oscillates periodically throughout the cell cycle, peaking at the G1/S transition,..
  24. Wang L, Hu H, Lin Y, Zhao Z, Tan L, Yu P, et al. CDK3 expression and its clinical significance in human nasopharyngeal carcinoma. Mol Med Rep. 2014;9:2582-6 pubmed publisher
    The aim of the current study was to investigate the expression of cyclin-dependent kinase 3 (CDK3) in human nasopharyngeal carcinoma (NPC) and to evaluate its association with the clinicopathological characteristics of patients with NPC...
  25. Meyerson M, Enders G, Wu C, Su L, Gorka C, Nelson C, et al. A family of human cdc2-related protein kinases. EMBO J. 1992;11:2909-17 pubmed
    ..The cdk3 gene, like cdc2 and cdk2, can complement cdc28 mutants of Saccharomyces cerevisiae, suggesting that all three of ..
  26. Guen V, Gamble C, Flajolet M, Unger S, Thollet A, Ferandin Y, et al. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Proc Natl Acad Sci U S A. 2013;110:19525-30 pubmed publisher
    ..Altogether, our results reveal an additional regulatory mechanism for ETS2, which plays key roles in cancer and development. They also shed light on the molecular mechanisms underlying STAR syndrome. ..
  27. Brewster C, Birkenheuer C, Vogt M, Quackenbush S, Rovnak J. The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8. Virology. 2011;409:299-307 pubmed publisher
    ..b>Cdk3 is also activated by cyclin C and phosphorylates retinoblastoma protein to initiate entry into the cell division ..
  28. Wang P, Chen S, Fang H, Wu X, Chen D, Peng L, et al. miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators. Oncotarget. 2016;7:929-45 pubmed publisher
    ..Direct binding of miR-214 to the 3'-untranslated regions of E2F2, CDK3, and CDK6 was verified by dual-luciferase reporter assay...
  29. Sasaguri T, Ishida A, Kosaka C, Nojima H, Ogata J. Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells. J Biol Chem. 1996;271:8345-51 pubmed
    ..PMA did not inhibit the gene expression of Cdk2, Cdk3, Cdk4, Cdk5, and cyclins G, C, and D, all of which began at 0-3 h...
  30. Schang L, Bantly A, Schaffer P. Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4. J Virol. 2002;76:7724-35 pubmed
    ..In contrast, neuronal expression of cdk7 and cytoplasmic cdk4 decreased during explant cultivation, whereas cdk3 was detected in the same small percentage of neurons before and after explant cultivation and cdks 1, 5, and 6 were ..