CDCA8

Summary

Gene Symbol: CDCA8
Description: cell division cycle associated 8
Alias: BOR, BOREALIN, DasraB, MESRGP, Dasra B, borealin, cell division cycle-associated protein 8, dasra-B, hDasra-B, pluripotent embryonic stem cell-related gene 3 protein
Species: human

Top Publications

  1. ncbi A family with the branchio-oto-renal syndrome: clinical and genetic correlations
    Alkis M Pierides
    Department of Nephrology, Nicosia General Hospital, Nicosia, Cyprus
    Nephrol Dial Transplant 17:1014-8. 2002
  2. ncbi Evidence of progression and fluctuation of hearing impairment in branchio-oto-renal syndrome
    Mathyus H Kemperman
    Department of Otorhinolaryngology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Int J Audiol 43:523-32. 2004
  3. ncbi Distributed and selective auditory representation of song repertoires in the avian song system
    Paul M Nealen
    Department of Biology, Indiana University of Pennsylvania, 114 Weyandt Hall, 975 Oakland Avenue, Indiana, PA 15705 1001, USA
    J Neurophysiol 96:3433-47. 2006
  4. doi SIX1 mutation screening in 247 branchio-oto-renal syndrome families: a recurrent missense mutation associated with BOR
    Amit Kochhar
    Doris Duke Clinical Research Fellowship, Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
    Hum Mutat 29:565. 2008
  5. ncbi [Synergistic effects of proteasome inhibitor and histone deacetylase inhibitor on apoptosis and aggresome formation in T lymphoma cells]
    Xiao Xing Jiang
    National Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Department of Hematology, Shanghai Ruijin Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200025, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:1215-9. 2009
  6. ncbi Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together
    A Arockia Jeyaprakash
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Cell 131:271-85. 2007
  7. pmc RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin
    Ulf R Klein
    Department of Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Mol Biol Cell 20:410-8. 2009
  8. doi Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis
    Reiko Ban
    Department of Biochemistry, Shimane University School of Medicine, Izumo 693 8501, Japan
    Genes Cells 16:652-69. 2011
  9. ncbi Drug target discovery by gene expression analysis: cell cycle genes
    M G Walker
    Incyte Genomics and Department of Medicine, Stanford University, 1475 Flamingo Way, Sunnyvale, CA, USA
    Curr Cancer Drug Targets 1:73-83. 2001
  10. ncbi Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer
    Junn Liang Chang
    Department of Pathology, Armed Forces Taoyuan General Hospital, Taoyuan County, Taiwan
    Exp Cell Res 312:962-73. 2006

Detail Information

Publications156 found, 100 shown here

  1. ncbi A family with the branchio-oto-renal syndrome: clinical and genetic correlations
    Alkis M Pierides
    Department of Nephrology, Nicosia General Hospital, Nicosia, Cyprus
    Nephrol Dial Transplant 17:1014-8. 2002
    The branchio-oto-renal (BOR) syndrome is an autosomal dominant disease characterized by hearing loss of early onset, preauricular pits, branchial clefts, and early progressive chronic renal failure in up to 40% of family affected members...
  2. ncbi Evidence of progression and fluctuation of hearing impairment in branchio-oto-renal syndrome
    Mathyus H Kemperman
    Department of Otorhinolaryngology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Int J Audiol 43:523-32. 2004
    We retrospectively analysed long-term serial audiometry data from patients with branchio-oto-renal (BOR) syndrome to show the features of progression and fluctuation in hearing impairment and relate the findings to age and magnetic ..
  3. ncbi Distributed and selective auditory representation of song repertoires in the avian song system
    Paul M Nealen
    Department of Biology, Indiana University of Pennsylvania, 114 Weyandt Hall, 975 Oakland Avenue, Indiana, PA 15705 1001, USA
    J Neurophysiol 96:3433-47. 2006
    ..Auditory responses were selective for multiple songs of the bird's own repertoire (BOR) over acoustically modified versions of these stimuli...
  4. doi SIX1 mutation screening in 247 branchio-oto-renal syndrome families: a recurrent missense mutation associated with BOR
    Amit Kochhar
    Doris Duke Clinical Research Fellowship, Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
    Hum Mutat 29:565. 2008
    Branchio-oto-renal syndrome (BOR) is a clinically heterogeneous autosomal dominant form of syndromic hearing loss characterized by variable hearing impairment, malformations of the pinnae, the presence of branchial arch remnants, and ..
  5. ncbi [Synergistic effects of proteasome inhibitor and histone deacetylase inhibitor on apoptosis and aggresome formation in T lymphoma cells]
    Xiao Xing Jiang
    National Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Department of Hematology, Shanghai Ruijin Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200025, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:1215-9. 2009
    The aim of the study was to explore the synergistic effect of the proteasome inhibitor bortezomib (bor) and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on apoptosis of T lymphoma cell lines Jurkat and Hut78, ..
  6. ncbi Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together
    A Arockia Jeyaprakash
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Cell 131:271-85. 2007
    ..The complex first localizes to centromeres and later associates with the central spindle and midbody. Survivin, Borealin, and INCENP are the three components of the CPC that regulate the activity and localization of its enzymatic ..
  7. pmc RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin
    Ulf R Klein
    Department of Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Mol Biol Cell 20:410-8. 2009
    ..Here, we identify Borealin, a component of the chromosomal passenger complex (CPC), as a mitotic target of SUMO...
  8. doi Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis
    Reiko Ban
    Department of Biochemistry, Shimane University School of Medicine, Izumo 693 8501, Japan
    Genes Cells 16:652-69. 2011
    ..Based on these results, we propose that Aurora-B is a novel mitotic SUMO substrate and that its kinase activity is fine-tuned by the SUMO system...
  9. ncbi Drug target discovery by gene expression analysis: cell cycle genes
    M G Walker
    Incyte Genomics and Department of Medicine, Stanford University, 1475 Flamingo Way, Sunnyvale, CA, USA
    Curr Cancer Drug Targets 1:73-83. 2001
    ..We present an example of the identification of previously-unrecognized human cell cycle genes, CDCA1 through CDCA8, that are co-expressed with known cell cycle genes including CDC2, CDC7, CDC23, cyclin, MCAK, mki67a, ..
  10. ncbi Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer
    Junn Liang Chang
    Department of Pathology, Armed Forces Taoyuan General Hospital, Taoyuan County, Taiwan
    Exp Cell Res 312:962-73. 2006
    Chromosomal passenger proteins including Aurora B, Survivin, and Borealin/Dasra B, also called CDCA8/FLJ10468, are known to play crucial roles during mitosis and cell division...
  11. pmc Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody
    Gerben Vader
    Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam
    EMBO Rep 7:85-92. 2006
    ..the mitotic cell by its companion chromosomal passenger proteins, inner centromere protein (INCENP), Survivin and Borealin/Dasra-B, thereby allowing it to act at the right place at the right time...
  12. doi Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation
    Eric Bourhis
    Department of Protein Engineering, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Biochemistry 48:6783-93. 2009
    ..Within the complex, the kinase Aurora B associates with Incenp, Survivin, and Borealin. The stoichiometry of the complex as well as a complete understanding of how these four components interact with ..
  13. pmc Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle
    Reto Gassmann
    Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Kings Buildings, Mayfield Rd, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 166:179-91. 2004
    ..Here, we describe Borealin, a novel member of the complex...
  14. pmc Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP
    Ulf R Klein
    Department of Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Mol Biol Cell 17:2547-58. 2006
    ..CPC), consisting of the serine/threonine kinase Aurora B, the inner centromere protein INCENP, Survivin, and Borealin/DasraB, has essential functions at the centromere in ensuring correct chromosome alignment and segregation...
  15. pmc Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres
    Susanne M A Lens
    Department of Medical Oncology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Mol Biol Cell 17:1897-909. 2006
    ..Consequently, these mutants failed to recruit Aurora B, Borealin/Dasra B, and BubR1 to centromeres and kinetochores, but they had retained the ability to recruit Aurora B and ..
  16. ncbi The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly
    Srinath C Sampath
    Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY 10021, USA
    Cell 118:187-202. 2004
    ..Here we report the identification of Dasra A and Dasra B, two new components of the vertebrate chromosomal passenger complex containing Incenp, Survivin, and the kinase ..
  17. ncbi Selective removal of heavy metals from metal-bearing wastewater in a cascade line reactor
    Jelena Pavlovic
    University of Belgrade, Faculty of Technology and Metallurgy, Department of Metallurgical Engineering, Karnegijeva 4, 11120 Belgrade, Serbia and Montenegro
    Environ Sci Pollut Res Int 14:518-22. 2007
    ..produced by sulfide ore mining and metallurgical activities in the Copper Mining and Smelting Complex Bor (RTB-BOR), Serbia...
  18. pmc Longitudinal survey of Staphylococcus aureus in cystic fibrosis patients using a multiple-locus variable-number of tandem-repeats analysis method
    Hoang Vu-Thien
    Universite Paris Sud 11, CNRS, UMR 8621, Institut de Genetique et Microbiologie, Orsay 91405, France
    BMC Microbiol 10:24. 2010
    ..Multiple-locus variable-number tandem repeat analysis (MLVA/VNTR) was used to survey S. aureus clinical isolates in a French paediatric CF centre...
  19. ncbi Current problems in national hospitals of Phnom Penh: finance and health care
    Sophoat Uy
    Human Resource Development Department, Ministry of Health, Kingdom of Cambodia No 151 153 Kampuchea Krom Blvd, Phnom Penh
    Nagoya J Med Sci 69:71-9. 2007
    ..The bed occupancy rates (BOR), average lengths of stay (ALS), hospital mortality rates (HMR), maternal and neonatal mortality rates, numbers of ..
  20. ncbi Simultaneous high-throughput determination of clenbuterol, ambroxol and bromhexine in pharmaceutical formulations by HPLC with potentiometric detection
    Grzegorz Bazylak
    Faculty of Science and Biomedicine, Department of Chemistry, University of Antwerp RUCA, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    J Pharm Biomed Anal 32:887-903. 2003
    ..ionophores improve the sensitivity for all mentioned drugs when compared with a tetrakis(p-chlorophenyl)borate (BOR)-based electrode as well as with single wavelength UV detection. Detection limits (S/N=3) of 2...
  21. pmc Natural variation in DNA methylation in ribosomal RNA genes of Arabidopsis thaliana
    Hye Ryun Woo
    Department of Biology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    BMC Plant Biol 8:92. 2008
    ..An epigenetic switch, mediated by DNA methylation and histone modification, turns rRNA genes on and off. However, little is known about the mechanisms that specify and maintain the patterns of NOR DNA methylation...
  22. doi Effects of overexpression of endogenous phenylalanine ammonia-lyase (PALrs1) on accumulation of salidroside in Rhodiola sachalinensis
    L Q Ma
    College of Plant Science, Jilin University, Changchun, China
    Plant Biol (Stuttg) 10:323-33. 2008
    Salidroside, a novel effective adaptogenic drug extracted from the medicinal plant Rhodiola sachalinensis A. Bor, can be derived from phenylalanine or tyrosine. Due to the scarcity of R...
  23. ncbi Eya1 expression in the developing ear and kidney: towards the understanding of the pathogenesis of Branchio-Oto-Renal (BOR) syndrome
    V Kalatzis
    Unité de Génétique des Déficits Sensoriels, URA CNRS 1968, Institut Pasteur Paris, France
    Dev Dyn 213:486-99. 1998
    Branchio-Oto-Renal (BOR) syndrome is an autosomal dominant, early developmental defect characterised by varying combinations of branchial (fistulas, sinuses, and cysts), outer, middle and inner ear, and renal anomalies...
  24. ncbi Protective effects of salidroside against acetaminophen-induced toxicity in mice
    Yan Ling Wu
    Key Laboratory of Organism Functional Factors of the Changbai Mountain, College of Pharmacy, Yanbian University, Jilin Province, China
    Biol Pharm Bull 31:1523-9. 2008
    The protective effect of salidroside (SDS) isolated from Rhodiola sachalinensis A. BOR. (Crassulaceae), was investigated in acetaminophen (APAP)-induced hepatic toxicity mouse model in comparison to N-acetylcysteine (NAC)...
  25. doi Hepatoprotective effects of salidroside on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice
    Yan Ling Wu
    Key Laboratory for Natural Resource of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Jilin Province, China
    J Pharm Pharmacol 61:1375-82. 2009
    The aim was to investigate the protective effect of salidroside isolated from Rhodiola sachalinensis A. Bor. (Crassulaceae) on D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure.
  26. ncbi Estrogen fluctuations, oral contraceptives and borderline personality
    M Catherine DeSoto
    Department of Psychology, University of Northern Iowa, Cedar Falls, IA 50614 0505, USA
    Psychoneuroendocrinology 28:751-66. 2003
    ..In the first study, 226 women were administered the Personality Assessment Inventory, borderline scales (PAI-BOR; L.C...
  27. ncbi Branchio-Oto-renal syndrome: a report on nine family groups
    C Bellini
    Servizio di Patologia Neonatale, Dipartimento Pediatria dell Università di Genova, and the Divisione di Nefrologia, Istituto G Gaslini, Genova, Italy
    Am J Kidney Dis 37:505-9. 2001
    This study reviews nine new families with branchio-oto-renal (BOR) syndrome (Online Mendelian Inheritance in Man [OMIM] 113650)...
  28. ncbi Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia
    P X Xu
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 23:113-7. 1999
    ..Drosophila melanogaster gene eyes absent (eya), results in the dominantly inherited disorders branchio-oto-renal (BOR) syndrome and branchio-oto (BO) syndrome, which are characterized by craniofacial abnormalities and hearing loss ..
  29. ncbi Oto-facio-cervical (OFC) syndrome is a contiguous gene deletion syndrome involving EYA1: molecular analysis confirms allelism with BOR syndrome and further narrows the Duane syndrome critical region to 1 cM
    S Rickard
    The North Thames East Regional Clinical Molecular Genetics Laboratory, London, UK
    Hum Genet 108:398-403. 2001
    Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder involving hearing loss, branchial defects, ear pits and renal abnormalities...
  30. ncbi Temporal bone findings on computed tomography imaging in branchio-oto-renal syndrome
    Evan J Propst
    Department of Otolaryngology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Laryngoscope 115:1855-62. 2005
    ..inspection and direct measurement on computerized tomography (CT) in individuals with branchio-oto-renal syndrome (BOR)...
  31. ncbi Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats
    M M Engler
    Department of Physiological Nursing, University of California San Francisco, 94143 0610, USA
    Proc Soc Exp Biol Med 218:234-7. 1998
    ..we showed that dietary gamma-linolenic acid (GLA), an omega-6 polyunsaturated fatty acid found in borage oil (BOR), attenuates the development of hypertension in young spontaneously hypertensive rats (SHR)...
  32. pmc Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid
    Pin Xian Xu
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Development 129:3033-44. 2002
    ..Mutations in human EYA1 cause congenital Branchio-Oto-Renal (BOR) syndrome, while targeted inactivation of murine Eya1 impairs early developmental processes in multiple organs, ..
  33. doi Comparative effects of estradiol, methyl-piperidino-pyrazole, raloxifene, and ICI 182 780 on gene expression in the murine uterus
    Angela M Davis
    Department of Biomedical Sciences, 440F Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA
    J Mol Endocrinol 41:205-17. 2008
    ..For some cancer-associated genes, including Klk1, Ihh, Cdc45l, and Cdca8, administration of MPP or raloxifene with estradiol resulted in greater expression than estradiol alone (P<0...
  34. doi Influence of litter size on the postnatal growth of rat pups: is there a rationale for litter-size standardization in toxicity studies?
    Ibrahim Chahoud
    Institute of Clinical Pharmacology and Toxicology, Charité University Medical School Berlin, Campus Benjamin Franklin, Garystrabetae 5, 14195 Berlin, Germany
    Environ Res 109:1021-7. 2009
    ..Two-hundred-forty-one untreated pregnant rats (Wistar, Bor:spf, TOR) delivered litters with 1-13 pups, being 10 the most frequent (24%) litter size. Pup mortality was 5.4%, 3...
  35. doi Branchio-oto-renal syndrome (BOR): novel mutations in the EYA1 gene, and a review of the mutational genetics of BOR
    Dana J Orten
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68164, USA
    Hum Mutat 29:537-44. 2008
    Branchio-oto-renal syndrome (BOR) is an autosomal dominant disorder characterized by the association of branchial and external ear malformations, hearing loss, and renal anomalies...
  36. ncbi Branchio-oto-renal syndrome
    Amit Kochhar
    Molecular Otolaryngology Research Laboratories, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 143:1671-8. 2007
    ..Three loci known to be associated with the BOR phenotype have been identified and two genes that act in a regulatory network have been cloned, EYA1 and SIX1...
  37. pmc Sequential assembly of centromeric proteins in male mouse meiosis
    María Teresa Parra
    Departamento de Biologia, Unidad de Biologia Celular, Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain
    PLoS Genet 5:e1000417. 2009
    ..We have found that during prophase I, the proteins of the chromosomal passenger complex Borealin, INCENP, and Aurora-B load sequentially to the inner centromere before Shugoshin 2 and MCAK...
  38. pmc Genetic covariance structure of the four main features of borderline personality disorder
    Marijn A Distel
    VU University Amsterdam, Department of Biological Psychology, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    J Pers Disord 24:427-44. 2010
    ..Using an extended twin design, multivariate genetic models were applied to the scales of the PAI-BOR, a self-report questionnaire tapping four main features of BPD (affective instability, identity problems, negative ..
  39. pmc Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development
    Kathrin Landgraf
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    Mol Cell Biol 30:5764-75. 2010
    ..Mutations in the human EYA1 gene are linked to BOR (branchio-oto-renal) syndrome, characterized by kidney defects, hearing loss, and branchial arch anomalies...
  40. doi Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation
    Tatsuya Tsukahara
    Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113 0032, Japan
    Nature 467:719-23. 2010
    ..passenger complex (CPC), composed of catalytic kinase Aurora B and regulatory components (INCENP, Survivin and Borealin), must be localized to centromeres to phosphorylate kinetochore substrates...
  41. pmc Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome
    Bethan E Hoskins
    Department of Pediatrics and of Human Genetics, University of Michigan, Ann Arbor, MI, USA
    Am J Hum Genet 80:800-4. 2007
    Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder characterized by the association of branchial arch defects, hearing loss, and renal anomalies. Mutations in EYA1 are known to cause BOR...
  42. ncbi Point mutation of an EYA1-gene splice site in a patient with oto-facio-cervical syndrome
    E Estefanía
    Servicio de Inmunologia, ENT Department, Hospital Universitario Puerta de Hierro, Universidad Autonoma de Madrid, Spain
    Ann Hum Genet 70:140-4. 2006
    Mutations of the EYA1 gene (8q13.3) are the most common known cause of the branchio-oto-renal dysplasia (BOR), an autosomal dominant disease that includes developmental defects of branchial arch structures, middle and/or inner ear and ..
  43. ncbi Autosomal-dominant branchio-otic (BO) syndrome is not allelic to the branchio-oto-renal (BOR) gene at 8q13
    S Kumar
    Department of Genetics, Center for Hereditary and Communication Disorders, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Am J Med Genet 76:395-401. 1998
    The manifestations of branchio-oto-renal syndrome (BOR), Treacher Collins syndrome, tricho-rhino-phalangeal syndrome, van der Woude syndrome, and Langer-Giedion syndrome are well-defined; these conditions represent clinically and ..
  44. ncbi Exclusion of the branchio-oto-renal syndrome locus (EYA1) from patients with branchio-oculo-facial syndrome
    A E Lin
    Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet 91:387-90. 2000
    ..erythematous wrinkled skin differ from the discrete cervical pits, cysts, and fistulas of the branchio-oto-renal (BOR) syndrome (MIM 113650)...
  45. ncbi Preparative isolation and purification of salidroside from the Chinese medicinal plant Rhodiola sachalinensis by high-speed counter-current chromatography
    H B Li
    Department of Botany, The University of Hong Kong, Hong Kong
    J Chromatogr A 932:91-5. 2001
    ..b>Bor. The crude salidroside was obtained by extraction with methanol from Rhodiola sachalinensis A. Bor...
  46. doi Eyes absent proteins: characterization of substrate specificity and phosphatase activity of mutants associated with branchial, otic and renal anomalies
    Amna Musharraf
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
    Chembiochem 9:2285-94. 2008
    ..the mouse Eya1 protein that harbours single point mutations that were associated with branchio-oto-renal syndrome (BOR), branchio-oto syndrome (BO) and ocular defects, respectively, in humans...
  47. doi Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib
    Addolorata Maria Luce Coluccia
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 112:1346-56. 2008
    ..vivo, showing a synergistic cytotoxicity with conventional and novel antimyeloma drugs (ie, melphalan, prednisone, bor-tezomib, and thalidomide)...
  48. ncbi Mutation of the EYA1 gene in patients with branchio-oto syndrome
    Takatoshi Yashima
    Department of Otolaryngology, Tokyo Medical and Dental University, Tokyo, Japan
    Acta Otolaryngol 123:279-82. 2003
    Branchio-oto-renal (BOR) and branchio-oto (BO) syndromes are autosomal dominant disorders, characterized by the presence of branchial, otic and renal anomalies of varying degrees of severity...
  49. ncbi [Effect of bortezomib and arabinoside on proliferation and apoptosis of K562 cell.]
    Shi Feng Lu
    Department of Hematology, the Affiliated Nanjing Children Hospital, Nanjing Medical University, Nanjing 210008, China
    Zhonghua Xue Ye Xue Za Zhi 31:42-5. 2010
    To investigate the effect of bortezomib (Bor) alone and in combination with arabinoside (Ara-C) on proliferation and apoptosis of leukemia cell line K562.
  50. pmc Identification of Rhodiola species by using RP-HPLC
    Qiang Wang
    Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, China
    J Zhejiang Univ Sci B 6:477-82. 2005
    ..coccinea A. Bor, R. junggarica C.Y. Yang et N.R. Cui spn., R. heterodonta A. Bor, R. linearifolia A. Bor, R. pamiro alaiucm A...
  51. pmc Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae
    Yuko Nakajima
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA
    Mol Biol Cell 20:1772-84. 2009
    ..A fourth subunit, Borealin/Dasra/CSC-1, is required for CPC targeting to centromeres and central spindles and has only been found in ..
  52. doi Mapping of genetic modifiers of Eya1 ( bor/bor ) in CAST/EiJ and BALB/cJ that suppress cochlear aplasia and associated deafness
    Haoru Niu
    Division of Cell Biology and Genetics, House Ear Institute, 2100 West Third Street, Los Angeles, CA, 90057, USA
    Mamm Genome 19:634-9. 2008
    Mice homozygous for the hypomorphic allele Eya1 ( bor ) exhibit cochlear aplasia, with associated deafness, and renal hypoplasia, similar to Branchio-Oto-Renal syndrome (BOR) in humans...
  53. ncbi A proposed new contiguous gene syndrome on 8q consists of Branchio-Oto-Renal (BOR) syndrome, Duane syndrome, a dominant form of hydrocephalus and trapeze aplasia; implications for the mapping of the BOR gene
    C Vincent
    Unité de Génétique Moléculaire Humaine CNRS URA 1445, Institut Pasteur, Paris
    Hum Mol Genet 3:1859-66. 1994
    ..the identification of a proposed previously undescribed contiguous gene syndrome consisting of Branchio-Oto-Renal (BOR) syndrome, Duane syndrome, hydrocephalus and trapeze aplasia...
  54. pmc SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation
    Xuguang Nie
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Development 137:755-65. 2010
    ..Six1 is a crucial regulator of renal development: mutations in human SIX1 cause branchio-oto-renal (BOR) syndrome and Six1(-/-) mice exhibit renal agenesis, although the ureter is present...
  55. ncbi Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, 1520 23rd Street South, MT 59405, USA
    Dev Biol 298:430-41. 2006
    ..in human EYA4 cause late-onset deafness at the DFNA10 locus, mutations in human EYA1 cause branchio-oto-renal (BOR) syndrome. Inactivation of Eya1 in mice causes an early arrest of the inner ear development at the otocyst stage...
  56. ncbi [Occupationally Orientated Medical Rehabilitation (BOR) for disabilities caused by orthopedic diseases]
    U Winkelhake
    Reha Zentrum Bad Eilsen, Orthopadische Klinik, Bad Eilsen
    Rehabilitation (Stuttg) 42:30-5. 2003
    ..to this project, "Occupationally Orientated Medical Rehabilitation" (Berufsorientierte medizinische Rehabilitation, BOR), the participants are extensively informed and tested in the retraining centre, they can also perform occupation-..
  57. doi Investigation of the correlation dependence between SO2 emission concentration and meteorological parameters: case study-Bor (Serbia)
    Ivana Z Ilic
    University of Belgrade, Technical Faculty in Bor, corrected Bor, Serbia
    J Environ Sci Health A Tox Hazard Subst Environ Eng 45:901-7. 2010
    This paper presents the investigation of the air-pollution management possibility in Bor (Serbia) using statistical analyses of the correlation dependence of SO(2) pollution concentration and meteorological parameters...
  58. ncbi Borderline pathology and the Personality Assessment Inventory (PAI): an evaluation of criterion and concurrent validity
    Michelle B Stein
    Derner Institute of Advanced Psychological Studies, Adelphi University, Garden City, NY 11530, USA
    J Pers Assess 88:81-9. 2007
    ..with borderline pathology (BP) would respond on the Personality Assessment Inventory (PAI; Morey, 1991) Borderline (BOR) scales in relation to patients without BP pathology...
  59. ncbi Molecular cloning and overexpression of a novel UDP-glucosyltransferase elevating salidroside levels in Rhodiola sachalinensis
    Lan Qing Ma
    Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, People s Republic of China
    Plant Cell Rep 26:989-99. 2007
    Salidroside is a novel effective adaptogenic drug extracted from the medicinal plant Rhodiola sachalinensis A. Bor. Because this plant is a rare resource and has low yield, there is great interest in enhancing the production of ..
  60. pmc SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes
    Rainer G Ruf
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 101:8090-5. 2004
    ..In branchio-oto-renal (BOR) syndrome, malformations of the kidney or urinary tract are associated...
  61. doi Episodes of extremely high concentrations of SO2 and particulate matter in the urban environment of Bor, Serbia
    Predrag Djordjevic
    University of Belgrade, Technical Faculty in Bor, Bor 19210, Serbia
    Environ Res 126:204-7. 2013
    ..presents the extremely high concentrations of SO2 and particulate matter measured in the urban area of the town Bor (Serbia) during August 2011...
  62. doi Bioaccumulation of arsenic and cadmium in birch and lime from the Bor region
    Slađana C Alagić
    Technical Faculty Bor, University of Belgrade, VJ 12, 19210, Bor, Serbia
    Arch Environ Contam Toxicol 65:671-82. 2013
    Copper production in the Bor region (east Serbia) during the last 100 years has influenced the quality of soil, water, and air. This pollution has endangered not only the biotope but all living organisms, including humans...
  63. ncbi Galardin (GM 6001), a broad-spectrum matrix metalloproteinase inhibitor, blocks bombesin- and LPA-induced EGF receptor transactivation and DNA synthesis in rat-1 cells
    Chintda Santiskulvong
    Department of Medicine, School of Medicine, University of California, Los Angeles, CA 90095 1786, USA
    Exp Cell Res 290:437-46. 2003
    ..in early and late response mitogenic signaling in Rat-1 cells stably transfected with the bombesin/GRP receptor (BoR-15 cells)...
  64. ncbi Neuroprotective effects of constituents of the oriental crude drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis
    Inhee Mook-Jung
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Biol Pharm Bull 25:1101-4. 2002
    We tested the constituents of two Rhodiola plants, Rhodiola sacra S. H. Fu and R. sachalinensis A. BOR, and an Oriental crude drug, Tokaku-joki-to, for their neuroprotective effects...
  65. ncbi Characterization of a novel cyclomaltodextrinase expressed from environmental DNA isolated from Bor Khleung hot spring in Thailand
    Kittapong Tang
    BIOTEC Central Research Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Klongluang, Pathumthani, Thailand
    FEMS Microbiol Lett 260:91-9. 2006
    ..to the alpha-amylase family was isolated directly from community DNA obtained from soil sediments collected from Bor Khleung hot spring in Thailand...
  66. doi Clinical importance of myeloid antigen expression in Moroccan patients with adult B-lineage acute lymphoblastic leukemia
    A Lahjouji
    Institut National D Hygiene, Rabat, Maroc
    Neoplasma 60:553-60. 2013
    ..Immunophenotyping was used to classify leukemic cells as Bor Tlymphoblasts and to identify the aberrant expression of myeloid-associated antigens...
  67. pmc Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer
    Handan Tuncel
    Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, Fatih, Istanbul 34303, Turkey
    Oncol Lett 3:1109-1114. 2012
    ..a key regulator of chromosome segregation and cytokinesis, and consists of Aurora B kinase, INCENP, Survivin and Borealin. Aurora B is a member of a family of serine/threonine protein kinases, and Survivin belongs to the inhibitors of ..
  68. pmc Combining multiple indicators to assess hospital performance in Iran using the Pabon Lasso Model
    Bahadori Mohammadkarim
    Health Management Research Centre, Baqyattallah University of Medical Sciences, Tehran, Iran
    Australas Med J 4:175-9. 2011
    ..Bed Occupancy Rate (BOR); 2. Bed Turnover (BTO); 3) Average Length of Stay (ALS)...
  69. doi Congenital unilateral facial nerve palsy as an unusual presentation of BOR syndrome
    Augustina Jankauskiene
    Children Hospital, Vilnius University Santariskiu klinikos, Santariskiu 4, Vilnius, 08406, Lithuania
    Eur J Pediatr 172:273-5. 2013
    ..CFNP is infrequently reported in association with branchio-oto-renal (BOR) syndrome...
  70. doi Addressing the questions of tomorrow: melphalan and new combinations as conditioning regimens before autologous hematopoietic progenitor cell transplantation in multiple myeloma
    Massimo Martino
    Oncology Department, Haematology and Bone Marrow Transplant Unit, Viale Europa, Reggio Calabria 89100, Italy
    Expert Opin Investig Drugs 22:619-34. 2013
    ..Administration of high-dose melphalan (HDM) is considered the standard conditioning regimen. Nevertheless, several attempts have recently been made to improve the conditioning phase of the HDC procedure...
  71. pmc Branchio-Oto-Renal Syndrome (BOR) associated with focal glomerulosclerosis in a patient with a novel EYA1 splice site mutation
    Maddalena Gigante
    Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
    BMC Nephrol 14:60. 2013
    Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder characterized by branchial, ear, and renal anomalies...
  72. doi Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality
    Yasunari Yamanaka
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Mech Dev 125:441-50. 2008
    b>Borealin/DasraB is a member of the chromosomal passenger protein complex (CPC) required for proper segregation of chromosomes during mitosis...
  73. pmc Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations
    Aaron N Patrick
    Program in Molecular Biology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Biol Chem 284:20781-90. 2009
    Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder characterized by hearing loss, branchial arch defects, and renal anomalies...
  74. ncbi Branchio-oto-renal syndrome: identification of a novel mutation in the EYA1 gene
    J Rodriguez-Soriano
    Department of Pediatrics, Hospital de Cruces and Basque University School of Medicine, Bilbao, Pais Vasco, Spain
    Pediatr Nephrol 16:550-3. 2001
    Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder characterized by the association of branchial cysts or fistulae, external ear malformation and/or preauricular pits, hearing loss, and renal anomalies...
  75. ncbi Narrowing the genetic interval and yeast artificial chromosome map in the branchio-oto-renal region on chromosome 8q
    S Kumar
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Genomics 31:71-9. 1996
    Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder characterized by branchial abnormality, hearing loss, and renal anomalies. Recently, the disease gene has been localized to chromosome 8q...
  76. doi Use of the Personality Assessment Inventory (PAI) in neuropsychological testing of psychiatric outpatients
    Grace G Aikman
    Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Appl Neuropsychol 15:176-83. 2008
    ..A was negatively related to the Somatic Complaints (SOM), Anxiety (ANX), Depression (DEP), and Borderline Features (BOR) scales of the PAI...
  77. ncbi [Malformation processes in the middle ear. Branchio-oto-renal syndrome (BOR)]
    G Motta

    Acta Otorhinolaryngol Ital 16:42-6. 1996
    The present report concerns a case of Branchio-Oto-Renal (BOR) dysplasia...
  78. ncbi Combined effects of bortezomib and daunorubicin on multiple myeloma cell KM3 in vitro
    Gui Fang Ouyang
    Department of Hematology, the First Hospital of Ningbo, Ningbo University Medical College, Ningbo 315010, Zhejiang Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:1468-71. 2009
    The aim of this study was to investigate the combined effects of bortezomib (Bor) and daunorubicin (DNR) or each drug alone on proliferation of human multiple myeloma cell line KM3...
  79. ncbi Identification of three novel mutations in human EYA1 protein associated with branchio-oto-renal syndrome
    S Kumar
    Department of Genetics, Center for Hereditary and Communication Disorders, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Hum Mutat 11:443-9. 1998
    The Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder characterized by branchial clefts, preauricular sinuses, hearing loss, and renal anomalies. Recent studies have shown that mutations in EYA1 are associated with BOR...
  80. ncbi The factor structure of the Personality Assessment Inventory-Borderline Features (PAI-BOR) Scale in a nonclinical sample
    K M Jackson
    University of Missouri-Columbia, MO 65211, USA
    J Pers Disord 15:536-45. 2001
    ..of Morey's (1991) proposed 4-factor structure on Personality Assessment Inventory-Borderline Features Scale (PAI-BOR; Morey, 1991) items in a sample of approximately 5,000 nonclinical participants...
  81. pmc Consequences of broad auditory filters for identification of multichannel-compressed vowels
    Pamela Souza
    Northwestern University, Evanston, IL, USA
    J Speech Lang Hear Res 55:474-86. 2012
    In view of previous findings (Bor, Souza, & Wright, 2008) that some listeners are more susceptible to spectral changes from multichannel compression (MCC) than others, this study addressed the extent to which differences in effects ..
  82. doi Mutation screening of the EYA1, SIX1, and SIX5 genes in an East Asian cohort with branchio-oto-renal syndrome
    Shih Hao Wang
    Department of Otolaryngology, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
    Laryngoscope 122:1130-6. 2012
    To explore the genetic characteristics of branchio-oto-renal (BOR) syndrome in an East Asian population.
  83. doi The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase
    Andreas Werner
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ ZMBH Alliance, Heidelberg, Germany
    Mol Cell 46:287-98. 2012
    ..of the RanBP2/RanGAP1*SUMO1/Ubc9 complex enabled us to characterize its activity on the endogenous substrate Borealin. We find that the complex is a composite E3 ligase rather than an E2-E3 complex, and demonstrate that complex ..
  84. ncbi Inner ear anomalies are frequent but nonobligatory features of the branchio-oto-renal syndrome
    Martijn H Kemperman
    Department of Otorhinolaryngology, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Arch Otolaryngol Head Neck Surg 128:1033-8. 2002
    To summarize the syndromic features and evaluate the presence of inner ear anomalies in 35 patients with branchio-oto-renal (BOR) syndrome from 6 families.
  85. ncbi Characterization of two immunoglobulin VH genes that are homologous to human rheumatoid factors
    P P Chen
    Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037
    Arthritis Rheum 32:72-6. 1989
    ..a VH1 germline gene (Humhv1263) that is closely related to the heavy chains of 2 human rheumatoid factors (RF), Bor and Kas...
  86. doi A combined CaO/electrochemical treatment of the acid mine drainage from the "Robule" Lake
    Visnja Orescanin
    Advanced Energy Ltd, Zagreb, Croatia
    J Environ Sci Health A Tox Hazard Subst Environ Eng 47:1186-91. 2012
    ..the treatment of the acid mine drainage (AMD) accumulated in the "Robule" Lake, which represents the part of the Bor copper mining and smelting complex, Serbia...
  87. ncbi [Seasonal variations in biomass and salidroside content in roots of Rhodiola sachalinensis as affected by gauze and red film shading]
    Xiufeng Yan
    College of Life Sciences, Northeast Forestry University, Harbin 150040, China
    Ying Yong Sheng Tai Xue Bao 15:382-6. 2004
    Rhodiola sachalinensis A. Bor, a perennial herb, belonging to the family Crassulaceae, is mainly distributed in mountains at the altitudes of 1,700-2,500 m...
  88. ncbi Branchio-oto-renal syndrome: detection of EYA1 and SIX1 mutations in five out of six Danish families by combining linkage, MLPA and sequencing analyses
    Kirsten Marie Sanggaard
    Wilhelm Johannsen Centre for Functional Genome Research, Section of Genetics, Institute of Cellular and Molecular Medicine, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Eur J Hum Genet 15:1121-31. 2007
    The branchio-oto-renal (BOR) syndrome is an autosomal-dominant disorder characterized by hearing loss, branchial and renal anomalies. BOR is genetically heterogeneous and caused by mutations in EYA1 (8q13.3), SIX1 (14q23.1), SIX5 (19q13...
  89. doi Speciation of Cr(III) and Cr(VI) in geological and water samples by ytterbium(III) hydroxide coprecipitation system and atomic absorption spectrometry
    Ali Duran
    Gaziosmanpasa University, Faculty of Science and Arts, Chemistry Department, 60250 Tokat, Turkey
    Food Chem Toxicol 49:1633-7. 2011
    ..4 Certified Reference Water, NIST 2710 Montana Soil). Method has been successfully applied to the chromium speciation for industrial waste water of leather factories located in Bor-Nigde, and also for mine and soil samples.
  90. pmc Chromosome-borne class A BOR-1 beta-Lactamase of Bordetella bronchiseptica and Bordetella parapertussis
    Marie Frédérique Lartigue
    Service de Bacteriologie Virologie, Hopital de Bicetre, and Faculté de Médecine Paris Sud, Universite Paris XI, 78 rue du General Leclerc, 94275 K Bicêtre, France
    Antimicrob Agents Chemother 49:2565-7. 2005
    A narrow-spectrum clavulanic acid-inhibited class A beta-lactamase, BOR-1, was identified in a Bordetella bronchiseptica clinical isolate. It shared 45% amino acid identity with L-2 from Stenotrophomonas maltophilia...
  91. ncbi Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1
    S Abdelhak
    Unit de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Hum Mol Genet 6:2247-55. 1997
    Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder, characterised by the association of branchial, otic and renal anomalies with variable degrees of severity...
  92. ncbi [Prophylaxis with acyclovir for herpes zoster infection during bortezomib-dexamethasone combination therapy]
    Yoshimi Hasegawa
    Pharmaceutical Division, Niigata Cancer Center Hospital
    Rinsho Ketsueki 50:488-94. 2009
    A novel molecular targeting drug, a proteasome inhibitor, bortezomib (Bor), has been reported to be highly effective for relapsed/refractory, as well as for newly diagnosed multiple myeloma, but is also associated with a high frequency ..
  93. doi Bortezomib and high-dose melphalan as conditioning regimen before autologous stem cell transplantation in patients with de novo multiple myeloma: a phase 2 study of the Intergroupe Francophone du Myelome (IFM)
    Murielle Roussel
    Hopital Purpan, Toulouse, France
    Blood 115:32-7. 2010
    ..July and December 2007 to receive bortezomib (1 mg/m(2) x 4) and melphalan (200 mg/m(2)) as conditioning regimen (Bor-HDM). Overall, 70% of patients achieved at least VGPR, including 17 patients with CR (32%) after ASCT...
  94. ncbi Inner ear and kidney anomalies caused by IAP insertion in an intron of the Eya1 gene in a mouse model of BOR syndrome
    K R Johnson
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Hum Mol Genet 8:645-53. 1999
    ..The human homolog of this gene, EYA1, has been shown to underly branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss with associated branchial and renal ..
  95. pmc Efficient chromosome biorientation and the tension checkpoint in Saccharomyces cerevisiae both require Bir1
    Vasso Makrantoni
    Wellcome Trust Centre for Gene Regulation and Expression, MSI WTB JBC Complex, College of Life Sciences, University of Dundee, Dundee DD15EH, United Kingdom
    Mol Cell Biol 29:4552-62. 2009
    ..Ipl1 associates with its activators Sli15 (INCENP), Nbl1 (Borealin), and Bir1 (Survivin), but while Sli15 clearly functions with Ipl1 to promote chromosome biorientation, the role ..
  96. doi A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development
    Margarida Avo Santos
    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Reprod 26:1868-81. 2011
    ..This important mitotic regulatory complex comprises the inner centromere protein (INCENP), survivin, borealin and Aurora B, or the meiotic kinase Aurora C.
  97. ncbi [Mechanism associated to enhancing the sensitivity of myeloma cells U266 to bortezomib by 2-methoxyestradiol]
    Shun Quan Wu
    Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:1424-8. 2011
    This study was aimed to explore the synergistic effect of 2-methoxyestradiol (2-ME2) and bortezomib (Bor) on the proliferative inhibition and apoptosis of U266 cell line and its possible mechanism...
  98. doi Diagnostic and surgical challenge: middle ear dermoid cyst in 12 month old with branchio-oto-renal syndrome and multiple middle-ear congenital anomalies
    D R Johnston
    Department of Otolaryngology and Communication Enhancement, Children s Hospital Boston, USA
    Int J Pediatr Otorhinolaryngol 75:1341-5. 2011
    Described is the first case report, to our knowledge, of a middle-ear dermoid in a child with branchio-oto-renal (BOR) syndrome. Radiographic, pathologic, and intraoperative figures are shown...
  99. doi Preauricular sinus, nephrolithiasis, infantine eczema and natal tooth: a new association
    Ayse Esra Yilmaz
    Department of Pediatrics, Fatih University, Faculty of Medicine, Alparslan Turkes Caddesi No 57, 06510, Ankara, Turkey
    Eur J Dermatol 21:234-7. 2011
    ..of other conditions or syndromes in 3-10% of cases, primarily in association with deafness and branchio-oto-renal (BOR) syndrome...
  100. doi Patent literature on mosquito repellent inventions which contain plant essential oils--a review
    Adrian Martin Pohlit
    Natural Products Department, National Institute for Amazon Research, Manaus, Brazil
    Planta Med 77:598-617. 2011
    ..Over 1/2 of all patents named just one EO. Citronella [Cymbopogon nardus (L.) Rendle, C.winterianus Jowitt ex Bor] and eucalyptus (Eucalyptus LʼHér. spp.) EOs were each cited in approximately 1/3 of all patents...
  101. doi Mutation screening of the EYA1, SIX1, and SIX5 genes in a large cohort of patients harboring branchio-oto-renal syndrome calls into question the pathogenic role of SIX5 mutations
    Pauline Krug
    AP HP, Service de Nephrologie Pediatrique, Hopital Necker Enfants Malades, Paris, France
    Hum Mutat 32:183-90. 2011
    Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder characterized by branchial, ear, and renal anomalies. Over 80 mutations in EYA1 have been reported in BOR...

Research Grants68

  1. The Role of Eya and its Interacting Gene Six in Mammalian Inner Ear Development
    Pin Xian Xu; Fiscal Year: 2010
    ..been shown to be a key gene for inner ear development: mutations in the human EYA1 gene cause Branchio-Oto-Renal (BOR) syndrome, a congenital birth defect that accounts for as many as 2% of profoundly deaf children, while ..
  2. Roles of chromosomal factors in chromosome segregation
    Hironori Funabiki; Fiscal Year: 2010
    ..we used expression screening to identify new metaphase chromosome-binding proteins, and discovered Dasra A and Dasra B, two new components of the vertebrate chromosomal passenger complex, which contains the kinase Aurora B...
  3. The Role of Eya and its Interacting Gene Six in Inner Ear Development
    Pin Xian Xu; Fiscal Year: 2009
    ..understand the developmental and molecular pathogenesis of inner ear defects that occur in the Branchio-Oto-Renal (BOR) syndrome...
  4. Retinal Cell-Fate Determination and Pattern Formation
    Graeme Mardon; Fiscal Year: 2010
    ..In humans, mutations in EYA1 and SIX1 cause the autosomal dominant disorder known as BOR (branchio-oto-renal) syndrome, characterized by branchial arch abnormalities, hearing loss, and kidney defects...
  5. Identifying new genes for branchio-oto-renal syndrome
    Friedhelm Hildebrandt; Fiscal Year: 2009
    Identification of new genes for branchio-oto-renal syndrome. Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder characterized by the association of hearing loss, renal anomalies, and branchial arch defects...
  6. EYA1 In Ear Development And Branchio-Oto-Renal Syndrome
    Jose Manaligod; Fiscal Year: 2009
    ..focus on the role of EYA1 in inner ear development, since EYA1 mutations result in branchio-otorenal syndrome (BOR), a common syndromic forms of hearing loss with a unique phenotype that may be reproducible and easily recognizable ..
  7. Prophylactic and Therapeutic Immunization against H. pylori in Rhesus Macaques
    JAY SOLNICK; Fiscal Year: 2007
    ..pylori infection in non-human primates. The project brings together the expertise of the Bor¿n lab, which discovered and characterized BabA in a series of elegant studies, and the Solnick lab, which has ..
  8. Prophylactic and Therapeutic Immunization against H. pylori in Rhesus Macaques
    JAY SOLNICK; Fiscal Year: 2007
    ..pylori infection in non-human primates. The project brings together the expertise of the Bor¿n lab, which discovered and characterized BabA in a series of elegant studies, and the Solnick lab, which has ..
  9. Roles of chromosomal factors in chromosome segregation
    Hironori Funabiki; Fiscal Year: 2009
    ..we used expression screening to identify new metaphase chromosome-binding proteins, and discovered Dasra A and Dasra B, two new components of the vertebrate chromosomal passenger complex, which contains the kinase Aurora B...
  10. Function of the Six and Eya Genes in Retinal Development
    JUSTIN KUMAR; Fiscal Year: 2007
    ..Six3 genes, while molecular lesions within the human Eyal gene result in congenital cataracts, Branchio-Oto-Renal (BOR) and Oto-FaciaI-Cervial (OFC) syndromes...
  11. Roles of transcription factors in kidney development
    Pin Xian Xu; Fiscal Year: 2010
    ..Defects in these genes in humans cause Branchio-Oto-Renal (BOR) syndrome, a congenital birth defect characterized by combinations of branchial, otic and renal anomalies...
  12. ROLE OF MICROGLIA IN HIV/DEMENTIA
    Francisco Gonzalez Scarano; Fiscal Year: 2004
    ..For those isolates (like the microglia-adapted HIV-1/BOR-15) which demonstrate a rapid entry phenotype, we will molecularly clone the envelopes, and define the mechanism of ..
  13. The Role of the Eyal Gene in Metanephric Induction
    Richard Maas; Fiscal Year: 2006
    ..Haploinsufficiency for human EYA 1 results in Branchio-Oto-Renal (BOR) syndrome...
  14. The Role of the Eyal Gene in Metanephric Induction
    Richard Maas; Fiscal Year: 2003
    ..Haploinsufficiency for human EYA 1 results in Branchio-Oto-Renal (BOR) syndrome...
  15. The Role of the Eyal Gene in Metanephric Induction
    Richard Maas; Fiscal Year: 2007
    ..Haploinsufficiency for human EYA 1 results in Branchio-Oto-Renal (BOR) syndrome...
  16. The Role of Eya and its Interacting Gene Six in Mammalian Inner Ear Development
    Pin Xian Xu; Fiscal Year: 2009
    ..been shown to be a key gene for inner ear development: mutations in the human EYA1 gene cause Branchio-Oto-Renal (BOR) syndrome, a congenital birth defect that accounts for as many as 2% of profoundly deaf children, while ..
  17. The Role of Eya and its Interacting Gene Six in Mammalian Inner Ear Development
    Pin Xian Xu; Fiscal Year: 2007
    ..been shown to be a key gene for inner ear development: mutations in the human EYA1 gene cause Branchio-Oto-Renal (BOR) syndrome, a congenital birth defect that accounts for as many as 2% of profoundly deaf children, while ..
  18. Eya1 and its Interacting Genes in Inner Ear Development
    Pin Xian Xu; Fiscal Year: 2006
    ..during the development of the auditory system and mutations in the human EYA1 gene cause Branchio-Oto-Renal (BOR) syndrome, a congenital birth defect that accounts for as many as 2% of profoundly deaf children...
  19. MOLECULAR GENETIC STUDIES OF BRANCHIOGENIC DISORDERS
    William Kimberling; Fiscal Year: 2006
    ..The Branchio-oto-renal (BOR), gene on chromosome 8q, has been identified as EYA1, however, some BOR, Branchio-renal (BR) and Branchio-oto (BO) ..
  20. Transcription Factors in Early Kidney Development
    Pin Xian Xu; Fiscal Year: 2007
    ..found to be expressed in the metanephric mesenchyme and mutations in the human EYA1 gene cause Branchio-Oto-Renal (BOR) syndrome, a congenital birth defect characterized by combinations of branchial, otic and renal anomalies...
  21. Study of a genetic network involved in ear development
    Rick Friedman; Fiscal Year: 2005
    ..We have designated this mutation Eya1 bor The human homologue of this gene, EYAJ, has been shown to underlie Branchio-Oto-Renal (B OR) syndrome, an autosomal ..
  22. MOLECULAR GENETIC STUDIES OF BRANCHIOGENIC DISORDERS
    Shrawan Kumar; Fiscal Year: 2004
    ..The Branchio-oto-renal (BOR), gene on chromosome 8q, has been identified as EYA1, however, some BOR, Branchio-renal (BR) and Branchio-oto (BO) ..
  23. Childhood Asthma Prevalence and Risk Factors at the Bor*
    Michael Lipsett; Fiscal Year: 2004
    ..Abstract not provided ..