CDCA8

Summary

Gene Symbol: CDCA8
Description: cell division cycle associated 8
Alias: BOR, BOREALIN, DasraB, MESRGP, borealin, Dasra B, cell division cycle-associated protein 8, dasra-B, hDasra-B, pluripotent embryonic stem cell-related gene 3 protein
Species: human
Products:     CDCA8

Top Publications

  1. Lens S, Rodriguez J, Vader G, Span S, Giaccone G, Medema R. Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres. Mol Biol Cell. 2006;17:1897-909 pubmed
    ..Consequently, these mutants failed to recruit Aurora B, Borealin/Dasra B, and BubR1 to centromeres and kinetochores, but they had retained the ability to recruit Aurora B and ..
  2. Bourhis E, Lingel A, Phung Q, Fairbrother W, Cochran A. Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. Biochemistry. 2009;48:6783-93 pubmed publisher
    ..Within the complex, the kinase Aurora B associates with Incenp, Survivin, and Borealin. The stoichiometry of the complex as well as a complete understanding of how these four components interact with ..
  3. Walker M. Drug target discovery by gene expression analysis: cell cycle genes. Curr Cancer Drug Targets. 2001;1:73-83 pubmed
    ..We present an example of the identification of previously-unrecognized human cell cycle genes, CDCA1 through CDCA8, that are co-expressed with known cell cycle genes including CDC2, CDC7, CDC23, cyclin, MCAK, mki67a, ..
  4. Gassmann R, Carvalho A, Henzing A, Ruchaud S, Hudson D, Honda R, et al. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol. 2004;166:179-91 pubmed
    ..Here, we describe Borealin, a novel member of the complex...
  5. Sampath S, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell. 2004;118:187-202 pubmed publisher
    ..Here we report the identification of Dasra A and Dasra B, two new components of the vertebrate chromosomal passenger complex containing Incenp, Survivin, and the kinase ..
  6. Vader G, Kauw J, Medema R, Lens S. Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep. 2006;7:85-92 pubmed
    ..the mitotic cell by its companion chromosomal passenger proteins, inner centromere protein (INCENP), Survivin and Borealin/Dasra-B, thereby allowing it to act at the right place at the right time...
  7. Klein U, Nigg E, Gruneberg U. Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. Mol Biol Cell. 2006;17:2547-58 pubmed
    ..CPC), consisting of the serine/threonine kinase Aurora B, the inner centromere protein INCENP, Survivin, and Borealin/DasraB, has essential functions at the centromere in ensuring correct chromosome alignment and segregation...
  8. Jeyaprakash A, Klein U, Lindner D, Ebert J, Nigg E, Conti E. Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell. 2007;131:271-85 pubmed
    ..The complex first localizes to centromeres and later associates with the central spindle and midbody. Survivin, Borealin, and INCENP are the three components of the CPC that regulate the activity and localization of its enzymatic ..
  9. Chang J, Chen T, Wang C, Chiang Y, Huang Y, Wong F, et al. Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. Exp Cell Res. 2006;312:962-73 pubmed
    Chromosomal passenger proteins including Aurora B, Survivin, and Borealin/Dasra B, also called CDCA8/FLJ10468, are known to play crucial roles during mitosis and cell division...

More Information

Publications132 found, 100 shown here

  1. Xu Z, He X, Shi X, Xia Y, Liu X, Wu H, et al. Analysis of differentially expressed genes among human hair follicle-derived iPSCs, induced hepatocyte-like cells, and primary hepatocytes. Stem Cell Res Ther. 2018;9:211 pubmed publisher
    ..were the major downregulated DEGs in HLCs/PHHs; the module analysis indicated that CDCA8, AURKB, and AURKA were the top upregulated DEGs in HLCs/PHHs...
  2. Wyrsch E, Roy Chowdhury P, Abraham S, Santos J, Darling A, Charles I, et al. Comparative genomic analysis of a multiple antimicrobial resistant enterotoxigenic E. coli O157 lineage from Australian pigs. BMC Genomics. 2015;16:165 pubmed publisher
    ..enterotoxin STa and a second allele of STb, whilst a prophage within O157:K88 734/3 encoded the serum survival gene bor. Both isolates harbor a large repertoire of antibiotic resistance genes but their association with mobile elements ..
  3. Thompson P, Tipney H, Brass A, Noyes H, Kemp S, Naessens J, et al. Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesis. PLoS ONE. 2010;5: pubmed publisher
    ..Rhd and Gypa), associated with red cell volume (Tmcc2) and indirectly associated with erythropoietic pathways (Cdca8, Cdkn2d, Cenpk)...
  4. Villarino M, Etxebeste O, Mendizabal G, Garzia A, Ugalde U, Espeso E. Boron Tolerance in Aspergillus nidulans Is Sustained by the SltA Pathway Through the SLC-Family Transporters SbtA and SbtB. Genes (Basel). 2017;8: pubmed publisher
    ..boric acid or borax-dependent expression of sbtA and sbtB, orthologs of Saccharomyces cerevisiae bor1, and a reduction in their transcript levels in a ?sltA mutant...
  5. Park G, Lee H, Yu H, Son J, Park S, Song K. Bordetella bronchiseptica bateriophage suppresses B. bronchiseptica-induced inflammation in swine nasal turbinate cells. Genes Genomics. 2018;40:1383-1388 pubmed publisher
    ..bronchiseptica bacteriophage (Bor-BRP-1). The regulation of cytokine profiles in B. bronchiseptica-induced inflammation by B...
  6. Yan H, Li Z, Shen Q, Wang Q, Tian J, Jiang Q, et al. Aberrant expression of cell cycle and material metabolism related genes contributes to hepatocellular carcinoma occurrence. Pathol Res Pract. 2017;213:316-321 pubmed publisher
    ..Proteins encoded by DEGs CDK1, BUB1, CDC20, NCAPG, NDC80, CDCA8, MAD2L1, CCNB1, CCNA2 and BIRC5 were hub genes with high degrees in the PPI network; further module analysis ..
  7. Vuorio A, Laukkala T, Navathe P, Budowle B, Bor R, Sajantila A. Bipolar Disorder in Aviation Medicine. Aerosp Med Hum Perform. 2017;88:42-47 pubmed publisher
    ..Vuorio A, Laukkala T, Navathe P, Budowle B, Bor R, Sajantila A. Bipolar disorder in aviation medicine. Aerosp Med Hum Perform. 2017; 88(1):42-47.
  8. Li S, Liu X, Zhou Y, Acharya A, Savkovic V, Xu C, et al. Shared genetic and epigenetic mechanisms between chronic periodontitis and oral squamous cell carcinoma. Oral Oncol. 2018;86:216-224 pubmed publisher
    ..Among 12 indirectly interacting cross-talk genes differentially expressed in OSCC, 3 genes (CDCA8, HIST1H3J, and RAD51) were significantly related to its prognosis...
  9. Dantas V, Freitas E, Della Rosa V, Lezirovitz K, de Moraes A, Ramos S, et al. Novel partial duplication of EYA1 causes branchiootic syndrome in a large Brazilian family. Int J Audiol. 2015;54:593-8 pubmed publisher
    ..Our findings implicate this EYA1 partial duplication segregating with BO phenotype in a Brazilian pedigree and is the first description of a large duplication leading to the BOR/BO syndrome.
  10. Li S, Liu X, Liu T, Meng X, Yin X, Fang C, et al. Identification of Biomarkers Correlated with the TNM Staging and Overall Survival of Patients with Bladder Cancer. Front Physiol. 2017;8:947 pubmed publisher
    ..analysis of hub genes suggested that lower expression of MMP11, COL5A2, CDC25B, TOP2A, CENPF, CDCA3, TK1, TPX2, CDCA8, AEBP1, and FOXM1were associated with better overall survival of BC patients...
  11. Tao W, Chen J, Tan D, Yang J, Sun L, Wei J, et al. Transcriptome display during tilapia sex determination and differentiation as revealed by RNA-Seq analysis. BMC Genomics. 2018;19:363 pubmed publisher
    ..Weighted gene correlation network analysis identified changes in the expression of Borealin, Gtsf1, tesk1, Zar1, Cdn15, and Rpl that were correlated with the expression of genes previously known to be ..
  12. Bidkhori G, Narimani Z, Hosseini Ashtiani S, Moeini A, Nowzari Dalini A, Masoudi Nejad A. Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma. PLoS ONE. 2013;8:e67552 pubmed publisher
    ..In few modules, the genes such as CCNA2 (Cyclin A2), CCNB2 (Cyclin B2), CDK1, CDK5, CDC27, CDCA5, CDCA8, ASPM, BUB1, KIF15, KIF2C, NEK2, NUSAP1, PRC1, SMC4, SYCE2, TFDP1, CDC42 and ARHGEF9 are present that play a ..
  13. Laukkala T, Bor R, Budowle B, Sajantila A, Navathe P, Sainio M, et al. Attention-Deficit/Hyperactivity Disorder and Fatal Accidents in Aviation Medicine. Aerosp Med Hum Perform. 2017;88:871-875 pubmed publisher
    ..Accurate evaluation of ADHD is essential because of its potential negative impact on aviation safety.Laukkala T, Bor R, Budowle B, Sajantila A, Navathe P, Sainio M, Vuorio A...
  14. Comisso E, Scarola M, Rosso M, Piazza S, Marzinotto S, Ciani Y, et al. OCT4 controls mitotic stability and inactivates the RB tumor suppressor pathway to enhance ovarian cancer aggressiveness. Oncogene. 2017;36:4253-4266 pubmed publisher
    ..parallel, OCT4 and NIPP1/CCNF drive the expression of the central Chromosomal Passenger Complex (CPC) components, Borealin, Survivin and the mitotic kinase Aurora B, promoting the clustering of supernumerary centrosomes to increase ..
  15. Yan B, Neilson K, Ranganathan R, Maynard T, Streit A, Moody S. Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development. Dev Dyn. 2015;244:181-210 pubmed publisher
    ..expressed in the nephric mesoderm, a structure that is functionally disrupted in the related branchio-otic-renal (BOR) syndrome...
  16. Silke J, Vaux D. IAP gene deletion and conditional knockout models. Semin Cell Dev Biol. 2015;39:97-105 pubmed publisher
    ..invertebrates and mammals has shown that it functions differently, as it is not a regulator of innate immunity or apoptosis, but acts together with INCENP, aurora kinase B and Borealin to allow chromosome segregation during mitosis.
  17. Carmena M, Wheelock M, Funabiki H, Earnshaw W. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol. 2012;13:789-803 pubmed publisher
    ..Aurora B is one of the most intensively studied kinases. In conjunction with inner centromere protein (INCENP), borealin (also known as Dasra) and survivin it forms the chromosomal passenger complex (CPC)...
  18. Helias Rodzewicz Z, Lourenco N, Bakari M, Capron C, Emile J. CDKN2A Depletion Causes Aneuploidy and Enhances Cell Proliferation in Non-Immortalized Normal Human Cells. Cancer Invest. 2018;36:338-348 pubmed publisher
    ..In this study, we found that significant down-regulation of CDKN2A, CHEK2, CDCA8, TP53BP1, and CCNDBP1 led to chromosome imbalances in two diploid non-immortalized human cell lines; however, only ..
  19. David J, Shanbag P. Branchio-oto-renal syndrome presenting with syndrome of hyporeninemic hypoaldosteronism. Saudi J Kidney Dis Transpl. 2017;28:1165-1168 pubmed publisher
    Branchio-oto-renal (BOR) syndrome is an autosomal dominant, clinically heterogeneous disorder characterized by branchial arch anomalies, hearing impairment, and renal malformations...
  20. Carlton J, Caballe A, Agromayor M, Kloc M, Martin Serrano J. ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. Science. 2012;336:220-5 pubmed publisher
    ..CHMP4C engaged the chromosomal passenger complex (CPC) via interaction with Borealin, which suggested a model whereby CHMP4C inhibits abscission upon phosphorylation by Aurora B...
  21. Watson J, Liljequist L. Using the Personality Assessment Inventory to Identify ADHD-Like Symptoms. J Atten Disord. 2015;: pubmed
    ..differed between those clients eventually diagnosed with ADHD and those not diagnosed (ANT-S, SCZ-T, MAN-A, ANX-C, BOR-S, and MAN-G)...
  22. Garcia Bonete M, Jensen M, Recktenwald C, Rocha S, Stadler V, Bokarewa M, et al. Bayesian Analysis of MicroScale Thermophoresis Data to Quantify Affinity of Protein:Protein Interactions with Human Survivin. Sci Rep. 2017;7:16816 pubmed publisher
    ..We demonstrate the Bayesian inference protocol on the known survivin:borealin interaction and on the putative protein-protein interactions between human survivin and two members of the human ..
  23. Hou T, Li X, Peng C. Borneol enhances the antidepressant effects of asiaticoside by promoting its distribution into the brain. Neurosci Lett. 2017;646:56-61 pubmed publisher
    ..brain tissues after FAB administration, while AS was not detected when administered alone, indicating that borneol (BOR) promoted its distribution into the rat brain...
  24. Patoulias I, Rachmani E, Farmakis K, Rafailidis V, Kalogirou M, Patoulias D. A Bilateral, Non-syndromic, Type III Second Branchial Arch Sinus in a Neonate: a Case Report. Acta Medica (Hradec Kralove). 2018;61:33-36 pubmed publisher
    ..in cases of a bilateral second branchial arch sinus, the branchio-oto-renal (BOR) or branchio-otic (BO) syndromes must be excluded; - ultrasound scan can be used for the thorough evaluation of the ..
  25. Saylor B, Angelini J, Deino A, Alene M, Fournelle J, Haile Selassie Y. Tephrostratigraphy of the Waki-Mille area of the Woranso-Mille paleoanthropological research project, Afar, Ethiopia. J Hum Evol. 2016;93:25-45 pubmed publisher
    ..three that are geochemically similar to widespread regional tuffs, specifically the Lomogol, Lokochot, and ?- Tulu Bor/Sidi Hakoma tuffs...
  26. Tsao F, Stephan D. Facile access to unsymmetrically substituted tellurium-boron based heterocycles. Chem Commun (Camb). 2017;53:6311-6314 pubmed publisher
    ..to afford species of the form Te((Ph)C[double bond, length as m-dash]C(C6F5))2BOR. The subsequent reaction with either 4-Br-C6H4CCH or 3-(C4H3S)CCH ..
  27. Fant X, Samejima K, Carvalho A, Ogawa H, Xu Z, Yue Z, et al. Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function. Biochem Soc Trans. 2010;38:1655-9 pubmed publisher
    The CPC [chromosomal passenger complex; INCENP (inner centromere protein), Aurora B kinase, survivin and borealin] is implicated in many mitotic processes...
  28. Gupta A, Ahamad S, Gupta E, Kant R, Mohanan K. Substrate-controlled product-selectivity in the reaction of the Bestmann-Ohira reagent with N-unprotected isatin-derived olefins. Org Biomol Chem. 2015;13:9783-8 pubmed publisher
    ..Treatment of 3-aryl/alkylideneoxindoles with BOR afforded spiropyrazoline-oxindoles, whereas 3-phenacylideneoxindoles furnished pyrazoloquinazolinones via a unique ..
  29. Shelke A, Suryavanshi G. An efficient one pot regioselective synthesis of a 3,3'-spiro-phosphonylpyrazole-oxindole framework via base mediated [1,3]-dipolar cycloaddition reaction of the Bestmann-Ohira reagent with methyleneindolinones. Org Biomol Chem. 2015;13:8669-75 pubmed publisher
    ..cycloaddition of an in situ generated anion of dialkyl 1-diazomethylphosphonate from the Bestmann-Ohira reagent (BOR) & methyleneindolinones has been developed...
  30. Kalinovic J, Serbula S, Radojevic A, Milosavljevic J, Kalinovic T, Steharnik M. Assessment of As, Cd, Cu, Fe, Pb, and Zn concentrations in soil and parts of Rosa spp. sampled in extremely polluted environment. Environ Monit Assess. 2018;191:15 pubmed publisher
    ..predominantly Rosa canina L.) in the Bor area, known for more than 100 years of mining and pyrometallurgical production of copper, as well as to determine ..
  31. Kabisch M, Lorenzo Bermejo J, Dünnebier T, Ying S, Michailidou K, Bolla M, et al. Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer. Carcinogenesis. 2015;36:256-71 pubmed publisher
    ..Fifteen SNPs in four CPC genes (INCENP, AURKB, BIRC5 and CDCA8) were genotyped in 88 911 European women from 39 case-control studies of the Breast Cancer Association Consortium...
  32. Đorđievski S, Ishiyama D, Ogawa Y, Stevanović Z. Mobility and natural attenuation of metals and arsenic in acidic waters of the drainage system of Timok River from Bor copper mines (Serbia) to Danube River. Environ Sci Pollut Res Int. 2018;25:25005-25019 pubmed publisher
    b>Bor, Krivelj, and Bela Rivers belong to the watershed of Timok River, which is a tributary of transboundary Danube River...
  33. Makrantoni V, Stark M. Efficient chromosome biorientation and the tension checkpoint in Saccharomyces cerevisiae both require Bir1. Mol Cell Biol. 2009;29:4552-62 pubmed publisher
    ..Ipl1 associates with its activators Sli15 (INCENP), Nbl1 (Borealin), and Bir1 (Survivin), but while Sli15 clearly functions with Ipl1 to promote chromosome biorientation, the role ..
  34. Pallaud C, Reck M, Juhász E, Szima B, Yu C, Burdaeva O, et al. Clinical genotyping and efficacy outcomes: exploratory biomarker data from the phase II ABIGAIL study of first-line bevacizumab plus chemotherapy in non-squamous non-small-cell lung cancer. Lung Cancer. 2014;86:67-72 pubmed publisher
    ..randomized, open-label, multicenter study evaluated the correlation between biomarkers and best overall response (BOR) to bevacizumab with chemotherapy in patients with advanced or recurrent non-small-cell lung cancer (NSCLC)...
  35. Wakuta S, Mineta K, Amano T, Toyoda A, Fujiwara T, Naito S, et al. Evolutionary Divergence of Plant Borate Exporters and Critical Amino Acid Residues for the Polar Localization and Boron-Dependent Vacuolar Sorting of AtBOR1. Plant Cell Physiol. 2015;56:852-62 pubmed publisher
    Boron (B) is an essential micronutrient for plants but is toxic when accumulated in excess. The plant BOR family encodes plasma membrane-localized borate exporters (BORs) that control translocation and homeostasis of B under a wide range ..
  36. Sun Y, Heng B, Tay S, Tan K. Unplanned 3-day re-attendance rate at Emergency Department (ED) and hospital's bed occupancy rate (BOR). Int J Emerg Med. 2015;8:82 pubmed publisher
    ..High bed occupancy rate (BOR) has been considered as a matter of reduced patient comfort and privacy...
  37. Pistillo M, Fontana V, Morabito A, Dozin B, Laurent S, Carosio R, et al. Soluble CTLA-4 as a favorable predictive biomarker in metastatic melanoma patients treated with ipilimumab: an Italian melanoma intergroup study. Cancer Immunol Immunother. 2019;68:97-107 pubmed publisher
    ..Associations of sCTLA-4 with best overall response (BOR) to IPI and immune-related adverse events (irAEs) were evaluated through logistic regression...
  38. Bor D, Barrett A, Schwartzman D, Seth A. Response to Ruby et al: On a 'failed' attempt to manipulate conscious perception with transcranial magnetic stimulation to prefrontal cortex. Conscious Cogn. 2018;65:334-341 pubmed publisher
    ..idea (Rounis, Maniscalco, Rothwell, Passingham, & Lau, 2010) motivated an attempted replication and extension (Bor, Schwartzman, Barrett, & Seth, 2017). Bor et al...
  39. Parkes W, Cushing S, Blaser S, Papsin B. Transmastoid access in branchio-oto-renal syndrome: A reappraisal of computed tomography imaging. Int J Pediatr Otorhinolaryngol. 2018;114:92-96 pubmed publisher
    ..that might affect transmastoid surgery such as cochlear implantation in cases of branchio-oto-renal syndrome (BOR). Retrospective review...
  40. Alagić S, Tošić S, Dimitrijević M, Antonijević M, Nujkić M. Assessment of the quality of polluted areas based on the content of heavy metals in different organs of the grapevine (Vitis vinifera) cv Tamjanika. Environ Sci Pollut Res Int. 2015;22:7155-75 pubmed publisher
    ..Vitis vinifera) cultivar Tamjanika were collected from the selected zones near the Mining and Smelting Complex Bor (East Serbia)...
  41. Labarrade F, Botto J, Domloge N. CRM1 and chromosomal passenger complex component survivin are essential to normal mitosis progress and to preserve keratinocytes from mitotic abnormalities. Int J Cosmet Sci. 2016;38:452-61 pubmed publisher
    ..The CPC is composed of four members: INCENP, survivin, borealin and aurora kinase B, and the disruption of the CPC during cell division induces mitotic spindle defects and ..
  42. Nishino M, Dahlberg S, Adeni A, Lydon C, Hatabu H, Janne P, et al. Tumor Response Dynamics of Advanced Non-small Cell Lung Cancer Patients Treated with PD-1 Inhibitors: Imaging Markers for Treatment Outcome. Clin Cancer Res. 2017;23:5737-5744 pubmed publisher
    ..b>Results: Tumor burden change at best overall response (BOR) ranged from -100% to +278% (median, +3.5%). Response rate (RR) was 18% (29/160)...
  43. Chu Y, Yao P, Wang W, Wang D, Wang Z, Zhang L, et al. Aurora B kinase activation requires survivin priming phosphorylation by PLK1. J Mol Cell Biol. 2011;3:260-7 pubmed publisher
    ..of spindle microtubules to kinetochore requires the chromosomal passenger of Aurora B kinase complex with borealin, INCENP and survivin (SUR)...
  44. Rola Łuszczak M, Materniak Kornas M, Pluta A, Podgórska K, Nielsen J, Stadejek T, et al. Transcriptional profiles of PBMCs from pigs infected with three genetically diverse porcine reproductive and respiratory syndrome virus strains. Mol Biol Rep. 2018;45:675-688 pubmed publisher
    ..explore the patterns of immune dysregulation after infection with two East European PRRSV strains from subtype 2 (BOR and ILI) in comparison to a Danish subtype 1 strain (DAN)...
  45. Zhao J, Wang Y, Yang Y, Zeng Y, Wang Q, Shao Y, et al. Isolation and identification of antioxidant and ?-glucosidase inhibitory compounds from fruit juice of Nitraria tangutorum. Food Chem. 2017;227:93-101 pubmed publisher
    Nitraria tangutorum Bor., having edible berries, is valued for reputed health benefits in Qinghai-Tibet plateau. The phytochemical research on the fruit juice of N...
  46. Iyer P, Dadu R, Gule Monroe M, Busaidy N, Ferrarotto R, Habra M, et al. Salvage pembrolizumab added to kinase inhibitor therapy for the treatment of anaplastic thyroid carcinoma. J Immunother Cancer. 2018;6:68 pubmed publisher
    ..Efficacy was evaluated with best overall response (BOR) using RECISTv1.1 criteria...
  47. Berry L, Chen C, Francia M, Guérin A, Graindorge A, Saliou J, et al. Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle: a prerequisite for productive endodyogeny. Cell Mol Life Sci. 2018;75:4417-4443 pubmed publisher
    ..In higher Eukaryotes, the four-subunit chromosomal passenger complex (CPC) (Aurora kinase B (ARKB)/INCENP/Borealin/Survivin) promotes chromosome bi-orientation by detaching incorrect kinetochore-microtubule attachments, playing ..
  48. Wheelock M, Wynne D, Tseng B, Funabiki H. Dual recognition of chromatin and microtubules by INCENP is important for mitotic progression. J Cell Biol. 2017;216:925-941 pubmed publisher
    The chromosomal passenger complex (CPC), composed of inner centromere protein (INCENP), Survivin, Borealin, and the kinase Aurora B, contributes to the activation of the mitotic checkpoint. The regulation of CPC function remains unclear...
  49. Jain T, Kosiorek H, Kung S, Shah V, Dueck A, González Calle V, et al. Treatment With Bortezomib-based Therapy, Followed by Autologous Stem Cell Transplantation, Improves Outcomes in Light Chain Amyloidosis: A Retrospective Study. Clin Lymphoma Myeloma Leuk. 2018;18:486-492.e1 pubmed publisher
    ..of 63 patients who underwent ASCT for light chain amyloidosis, 34 received bortezomib-based therapy before ASCT (Bor-ASCT) and 29 did not receive bortezomib therapy (non-Bor-ASCT)...
  50. Gohard F, St Cyr D, Tyers M, Earnshaw W. Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo. Open Biol. 2014;4:140163 pubmed publisher
    ..The CPC consists of Aurora B kinase, inner centromere protein (INCENP), and the targeting subunits survivin and borealin/Dasra B. INCENP is a scaffolding subunit for the CPC and activates Aurora B via its conserved IN-box domain...
  51. Lee J, Kim C, Kim S, Sethi G, Ahn K. Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway. Cancer Lett. 2015;360:280-93 pubmed publisher
    ..The in vivo effect of FOH on the growth of human MM xenograft tumors alone and in combination with bortezomib (Bor) in athymic nu/nu female mice was also investigated...
  52. Drobyshev E, Solovyev N, Ivanenko N, Kombarova M, Ganeev A. Trace element biomonitoring in hair of school children from a polluted area by sector field inductively coupled plasma mass spectrometry. J Trace Elem Med Biol. 2017;39:14-20 pubmed publisher
    ..A case group, residing in a proximity to the toxic waste disposal grounds (Krasniy Bor), has been assessed vs. controls from a non-urban settlement Seltso...
  53. Wang Y, Sun S, Qiu Y, Xing Q, Lu W. A novel mutation in EYA1 in a Chinese family with Branchio-oto-renal syndrome. BMC Med Genet. 2018;19:139 pubmed publisher
    Branchio-oto-renal (BOR) syndrome is a dominant autosomal disorder characterized by phenotypes such as hearing loss, branchial fistulae, preauricular pits, and renal abnormalities...
  54. Ahamad S, Gupta A, Kant R, Mohanan K. Domino reaction involving the Bestmann-Ohira reagent and α,β-unsaturated aldehydes: efficient synthesis of functionalized pyrazoles. Org Biomol Chem. 2015;13:1492-9 pubmed publisher
    A mild, efficient and rapid domino reaction involving the Bestmann-Ohira reagent (BOR) and α,β-unsaturated aldehydes has been developed for the synthesis of densely functionalized vinylpyrazoles...
  55. Carmena M, Pinson X, Platani M, Salloum Z, Xu Z, Clark A, et al. The chromosomal passenger complex activates Polo kinase at centromeres. PLoS Biol. 2012;10:e1001250 pubmed publisher
    ..subunit of the chromosomal passenger complex (CPC), which consists of Aurora B kinase, INCENP, Survivin, and Borealin/Dasra B, also interacts with Polo kinase in Drosophila cells...
  56. Conde M, Michen S, Wiedemuth R, Klink B, Schrock E, Schackert G, et al. Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells. BMC Cancer. 2017;17:889 pubmed publisher
    ..Additionally, Survivin plays an essential role during mitosis. Together with its molecular partners Aurora B, Borealin and inner centromere protein it secures bipolar chromosome segregation...
  57. Matić D, Vlahovic M, Kolarević S, Peric Mataruga V, Ilijin L, Mrdakovic M, et al. Genotoxic effects of cadmium and influence on fitness components of Lymantria dispar caterpillars. Environ Pollut. 2016;218:1270-1277 pubmed publisher
    ..were collected from two locations in Serbia - the uncontaminated Homolje mountains and a metal-polluted area near Bor copper mines, smelter and refinery...
  58. Cho Y, Kim S, Son H, Cho D, Kang S. The effect of interligand energy transfer on the emission spectra of heteroleptic Ir complexes. Phys Chem Chem Phys. 2017;19:8778-8786 pubmed publisher
    ..introduced two types of ancillary ligands: (1) non-luminescent ancillary ligands, namely tetrakis(pyrazolyl)borate (bor) and picolinate (pic), which were employed for the preparation of Ir(dfppy)2(bor) and Ir(dfppy)2
  59. Unzaki A, Morisada N, Nozu K, Ye M, Ito S, Matsunaga T, et al. Clinically diverse phenotypes and genotypes of patients with branchio-oto-renal syndrome. J Hum Genet. 2018;63:647-656 pubmed publisher
    Branchio-oto-renal (BOR) syndrome is a rare autosomal dominant disorder characterized by branchiogenic anomalies, hearing loss, and renal anomalies...
  60. Shimazaki C, Fuchida S, Suzuki K, Ishida T, Imai H, Sawamura M, et al. Phase 1 study of bortezomib in combination with melphalan and dexamethasone in Japanese patients with relapsed AL amyloidosis. Int J Hematol. 2016;103:79-85 pubmed publisher
    We performed a phase 1 study to evaluate the safety and feasibility of bortezomib (BOR) with melphalan and dexamethasone (BMD) in patients with light chain amyloidosis (AL) without severe cardiac failure...
  61. Harel T, Yoon W, Garone C, Gu S, Coban Akdemir Z, Eldomery M, et al. Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes. Am J Hum Genet. 2016;99:831-845 pubmed publisher
    ..Tissue-specific overexpression of borR534W, the Drosophila mutation homologous to the human c.1582C>T (p...
  62. Thapa R, Nguyen H, Jeong J, Shin B, Ku S, Choi H, et al. Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers. Nanomedicine. 2017;13:885-896 pubmed publisher
    ..We aimed to prepare vorinostat (Vor) and bortezomib (Bor) combination-loaded zein nanoparticles (ZNP, ZNP/VB) for treating metastatic prostate cancers...
  63. Que W, Chen J. [Ad-NK4 Enhances the Chemosensitivity of Human Multiple Myeloma RPMI 8226 Cells to Bortezomib]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1079-85 pubmed publisher
    To investigate if Ad-NK4 can enhance the chemosensitivity of human multiple myeloma RPMI 8226 cells to bortezomib(BOR)...
  64. Liu H, Que W. [Establishment of BOR-Resistant U266 Cell Line and the Detection of Its Biological Activities]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1722-1726 pubmed publisher
    To establish bortezomib (BOR)-resistant human multiple myeloma U266 cell line U266/BOR and to detect its biological characteristics...
  65. Nwagbara V, Rasiah R. Rethinking health care commercialization: evidence from Malaysia. Global Health. 2015;11:44 pubmed publisher
    ..The study relied on utilization ratios, bed occupancy rates (BOR), bed turnover rates (BTR) and average length of stay (ALOS)...
  66. Au P, Chernos J, Thomas M. Review of the recurrent 8q13.2q13.3 branchio-oto-renal related microdeletion, and report of an additional case with associated distal arthrogryposis. Am J Med Genet A. 2016;170:2984-2987 pubmed publisher
    ..2q13.3 encompassing EYA1 have been recently described in the literature as a cause of branchio-oto-renal syndrome (BOR). Other clinical features of this recurrent microdeletion syndrome are still being delineated...
  67. Ho A, Dunn L, Sherman E, Fury M, Baxi S, Chandramohan R, et al. A phase II study of axitinib (AG-013736) in patients with incurable adenoid cystic carcinoma. Ann Oncol. 2016;27:1902-8 pubmed publisher
    ..The primary end point was best overall response (BOR)...
  68. Tošić S, Alagić S, Dimitrijević M, Pavlović A, Nujkić M. Plant parts of the apple tree (Malus spp.) as possible indicators of heavy metal pollution. Ambio. 2016;45:501-12 pubmed publisher
    ..from polluted sites near The Mining and Smelting Complex Bor (Serbia). The aim of this study was to examine if the obtained results can be used for biomonitoring purposes...
  69. Kim S, Seo S, Lee H, Choi H, Jeon S, Lee H, et al. A Prospective Multicenter Trial of the Efficacy and Tolerability of Neoadjuvant Sunitinib for Inoperable Metastatic Renal Cell Carcinoma. J Korean Med Sci. 2016;31:1983-1988 pubmed publisher
    ..The best overall response (BOR), safety profile, and changes in quality of life during NST were assessed using the RECIST criteria (version 1...
  70. Wang X, Lu W, Gu Z, Wei Z, Zhou H. Topology-guided design of an anionic bor-network for photocatalytic [Ru(bpy)3](2+) encapsulation. Chem Commun (Camb). 2016;52:1926-9 pubmed publisher
    An anionic metal-organic framework, PCN-99, has been synthesized through a topology-guided strategy; its underlying bor-net is realized by the use of a tetrahedral [In(COO)4](-) node and a judiciously designed trigonal planar linker...
  71. Radojevic A, Serbula S, Kalinovic T, Kalinovic J, Steharnik M, Petrović J, et al. Metal/metalloid content in plant parts and soils of Corylus spp. influenced by mining-metallurgical production of copper. Environ Sci Pollut Res Int. 2017;24:10326-10340 pubmed publisher
    The town of Bor and its surroundings (Serbia) have been under environmental pollution for more than a century, due to exploitation of large copper deposits. Naturally present Corylus spp...
  72. Serbula S, Milosavljevic J, Radojevic A, Kalinovic J, Kalinovic T. Extreme air pollution with contaminants originating from the mining-metallurgical processes. Sci Total Environ. 2017;586:1066-1075 pubmed publisher
    Levels of SO2 and metals/metalloids in the air near a copper smelter in Bor (Serbia) from 2009 to 2015 were presented in this study...
  73. Greenberg V, Lazarev I, Frank Y, Dudnik J, Ariad S, Shelef I. Semi-automatic volumetric measurement of response to chemotherapy in lung cancer patients: How wrong are we using RECIST?. Lung Cancer. 2017;108:90-95 pubmed publisher
    ..CV was larger than SMV in most patients both at baseline and at best overall response (BOR)...
  74. Doherty K, Meere M, Piiroinen P. A mathematical model of Aurora B activity in prophase and metaphase. Math Biosci. 2016;277:153-65 pubmed publisher
    ..is a protein that controls several processes in mitosis when it is found associated with INCENP, Survivin and Borealin in a complex known as the Chromosomal Passenger Complex...
  75. Pike T, Brownlow N, Kjaer S, Carlton J, Parker P. PKC? switches Aurora B specificity to exit the abscission checkpoint. Nat Commun. 2016;7:13853 pubmed publisher
    ..Aurora B specificity, with increased phosphorylation of a subset of target substrates, including the CPC subunit Borealin. This switch is essential for abscission checkpoint exit...
  76. Salih D, Mwacharo J, Pelle R, Njahira M, Odongo D, Mbole Kariuki M, et al. Genetic diversity and population structure of Theileria parva in South Sudan. Ticks Tick Borne Dis. 2018;9:806-813 pubmed publisher
    ..parva by species-specific PCR, were collected from cattle from four regions in South Sudan (Bor = 62; Juba = 45; Kajo keji = 41 and Yei = 30) were genotyped using 14 microsatellite markers ..
  77. Lawrenson K, Li Q, Kar S, Seo J, Tyrer J, Spindler T, et al. Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer. Nat Commun. 2015;6:8234 pubmed publisher
    ..For three cis-eQTL associations (P<1.4 × 10(-3), FDR<0.05) at 1p36 (CDC42), 1p34 (CDCA8) and 2q31 (HOXD9), we evaluate the functional role of each candidate by perturbing expression of each gene in ..
  78. Reece D, Trieu Y, Masih Khan E, Atenafu E, Chen C, Prica A, et al. Cyclophosphamide and Bortezomib With Prednisone or Dexamethasone for the Treatment of Relapsed and Refractory Multiple Myeloma. Clin Lymphoma Myeloma Leuk. 2016;16:387-94 pubmed publisher
    ..CyBorP, originally developed at our center to include weekly bortezomib (Bor) and alternate-day prednisone (P), was recently modified so that weekly dexamethasone (D) replaced prednisone...
  79. Shockey B, Billet G, Salas Gismondi R. A new species of Trachytherus (Notoungulata: Mesotheriidae) from the late Oligocene (Deseadan) of Southern Peru and the middle latitude diversification of early diverging mesotheriids. Zootaxa. 2016;4111:565-83 pubmed publisher
    ..discrete region in the middle latitudes of western South America that we refer to as the Bolivian Orocline Region (BOR)...
  80. Cho S, Lipson E, Im H, Rowe S, Gonzalez E, Blackford A, et al. Prediction of Response to Immune Checkpoint Inhibitor Therapy Using Early-Time-Point 18F-FDG PET/CT Imaging in Patients with Advanced Melanoma. J Nucl Med. 2017;58:1421-1428 pubmed publisher
    ..Performance characteristics of each metric to predict best overall response (BOR) at ≥ 4 mo were assessed...
  81. Jeremic S, Beškoski V, Djokic L, Vasiljevic B, Vrvić M, Avdalović J, et al. Interactions of the metal tolerant heterotrophic microorganisms and iron oxidizing autotrophic bacteria from sulphidic mine environment during bioleaching experiments. J Environ Manage. 2016;172:151-61 pubmed publisher
    ..in biofilms with iron oxidizing autotrophic bacteria both from the sulphidic mine environment (copper mine Bor, Serbia)...
  82. Nujkić M, Dimitrijević M, Alagić S, Tošić S, Petrović J. Impact of metallurgical activities on the content of trace elements in the spatial soil and plant parts of Rubus fruticosus L. Environ Sci Process Impacts. 2016;18:350-60 pubmed publisher
    ..and in topsoil, collected from eight different locations around the copper smelter in Bor, Serbia. Extremely high concentrations of Cu were determined in the soil and in R. fruticosus L...
  83. Silva C, Wanderley Teixeira V, Cunha F, Oliveira J, Dutra K, Navarro D, et al. Biochemical parameters of Spodoptera frugiperda (J. E. Smith) treated with citronella oil (Cymbopogon winterianus Jowitt ex Bor) and its influence on reproduction. Acta Histochem. 2016;118:347-52 pubmed publisher
    ..Therefore, sub-lethal doses of citronella oil alters the biochemical profile of S. frugiperda larvae, causing damage to their reproductive histophysiology and results in diminished reproduction or reproductive failure. ..
  84. Ban R, Nishida T, Urano T. Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis. Genes Cells. 2011;16:652-69 pubmed publisher
    ..Based on these results, we propose that Aurora-B is a novel mitotic SUMO substrate and that its kinase activity is fine-tuned by the SUMO system. ..
  85. Liu J, Cheng F, Deng L. MLL5 maintains genomic integrity by regulating the stability of the chromosomal passenger complex through a functional interaction with Borealin. J Cell Sci. 2012;125:4676-85 pubmed publisher
    ..Biochemical analyses further demonstrated that the central domain of MLL5 interacted with the C-terminus of Borealin, and the interaction is essential to maintain the stability of Borealin...
  86. Wang Y, Zhao Z, Bao X, Fang Y, Ni P, Chen Q, et al. Borealin/Dasra B is overexpressed in colorectal cancers and contributes to proliferation of cancer cells. Med Oncol. 2014;31:248 pubmed publisher
    b>Borealin/Dasra B, also called cell division cycle associated 8, is a member of the chromosomal passenger complex and plays a crucial role during mitosis and cell division...
  87. Yamagishi Y, Honda T, Tanno Y, Watanabe Y. Two histone marks establish the inner centromere and chromosome bi-orientation. Science. 2010;330:239-43 pubmed publisher
    ..Haspin colocalizes with cohesin by associating with Pds5, whereas Bub1 localizes at kinetochores. Thus, the inner centromere is defined by intersection of two histone kinases. ..
  88. Fackler M, Wolter P, Gaubatz S. The GAR domain of GAS2L3 mediates binding to the chromosomal passenger complex and is required for localization of GAS2L3 to the constriction zone during abscission. FEBS J. 2014;281:2123-35 pubmed publisher
    ..Biochemical assays show that GAS2L3 directly interacts with the C-terminus of borealin and the N-terminus of survivin...
  89. Alagić S, Jovanović V, Mitić V, Cvetković J, Petrović G, Stojanović G. Bioaccumulation of HMW PAHs in the roots of wild blackberry from the Bor region (Serbia): Phytoremediation and biomonitoring aspects. Sci Total Environ. 2016;562:561-570 pubmed publisher
    ..were collected from the urban-industrial and rural locations near "The Copper Mining and Smelting Complex Bor" (Serbia); they were analyzed by gas chromatographic-mass spectrometric method to determine the content of high-..
  90. Sauer G, Körner R, Hanisch A, Ries A, Nigg E, Sillje H. Proteome analysis of the human mitotic spindle. Mol Cell Proteomics. 2005;4:35-43 pubmed
    ..in transfected mitotic cells, resulting in the identification of six genuine spindle components (KIAA0008, CdcA8, KIAA1187, FLJ12649, FLJ90806, and C20Orf129)...
  91. Xia F, Canovas P, Guadagno T, Altieri D. A survivin-ran complex regulates spindle formation in tumor cells. Mol Cell Biol. 2008;28:5299-311 pubmed publisher
    ..Therefore, survivin is a novel effector of Ran signaling, and this pathway may be preferentially exploited for spindle assembly in tumor cells. ..
  92. Knauer S, Bier C, Habtemichael N, Stauber R. The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 2006;7:1259-65 pubmed
    The chromosomal passenger complex (CPC) of Aurora-B, Borealin, INCENP (inner centromere protein) and Survivin coordinates essential chromosomal and cytoskeletal events during mitosis...