CDCA7L

Summary

Gene Symbol: CDCA7L
Description: cell division cycle associated 7 like
Alias: JPO2, RAM2, cell division cycle-associated 7-like protein, transcription factor RAM2
Species: human
Products:     CDCA7L

Top Publications

  1. Huang A, Ho C, Ponzielli R, Barsyte Lovejoy D, Bouffet E, Picard D, et al. Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res. 2005;65:5607-19 pubmed
    ..We identified a novel MycNTD binding protein, JPO2, which shows nuclear colocalization with c-Myc, and interacts with c-Myc both in vitro and in mammalian cells...
  2. Shen F, Li X, Ma J, Wang X, Zhao S, Meng L, et al. Cell division cycle associated 7 like predicts unfavorable prognosis and promotes invasion in glioma. Pathol Res Pract. 2019;215:50-56 pubmed publisher
    Cell division cycle associated 7 like (CDCA7L) belongs to the JPO protein family, which is recently identified as a target gene of c-Myc and is frequently dysregulated in multiple cancers...
  3. Wu S, Hsiao Y, Chen J, Lin J, Hsu S, Hsia T, et al. Bufalin alters gene expressions associated DNA damage, cell cycle, and apoptosis in human lung cancer NCI-H460 cells in vitro. Molecules. 2014;19:6047-57 pubmed publisher
    ..72 fold. 201 genes related to cell cycles were affected. CCPG1 was down-regulated by 2.11 fold and CDCA7L by 2.71 fold...
  4. Xue L, Klinnawee L, Zhou Y, Saridis G, Vijayakumar V, Brands M, et al. AP2 transcription factor CBX1 with a specific function in symbiotic exchange of nutrients in mycorrhizal Lotus japonicus. Proc Natl Acad Sci U S A. 2018;115:E9239-E9246 pubmed publisher
    ..We show that CBX1 activates expression of lipid metabolic genes including glycerol-3-phosphate acyltransferase RAM2 implicated in acylglycerol biosynthesis...
  5. Lin T, Li J, Li Q, Li X, Liu C, Zeng N, et al. R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc. Mol Cancer Res. 2018;16:1940-1951 pubmed publisher
    ..New therapeutic targets and approaches are urgently needed. The current study reports elevated expression of R1 (CDCA7L/RAM2/JPO2), a c-Myc-interacting protein and transcription factor, in human prostate cancer tissue specimens...
  6. Takeda N, Handa Y, Tsuzuki S, Kojima M, Sakakibara H, Kawaguchi M. Gibberellins interfere with symbiosis signaling and gene expression and alter colonization by arbuscular mycorrhizal fungi in Lotus japonicus. Plant Physiol. 2015;167:545-57 pubmed publisher
    ..AM hyphal entry into the host root and suppressed the expression of Reduced Arbuscular Mycorrhization1 (RAM1) and RAM2 homologs that function in hyphal entry and arbuscule formation...
  7. Luginbuehl L, Menard G, Kurup S, van Erp H, Radhakrishnan G, Breakspear A, et al. Fatty acids in arbuscular mycorrhizal fungi are synthesized by the host plant. Science. 2017;356:1175-1178 pubmed publisher
    ..fungi, which are fatty acid auxotrophs, and this lipid export requires the glycerol-3-phosphate acyltransferase RAM2, a direct target of RAM1...
  8. Rand K, Song C, Dean E, Serie D, Curtin K, Sheng X, et al. A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci. Cancer Epidemiol Biomarkers Prev. 2016;25:1609-1618 pubmed
    ..3 clustered around an enhancer at the 3' end of the CDCA7L transcription termination site. A missense variant at 17p11.2 (rs34562254, Pro251Leu, OR, 1.32; P = 2...
  9. Balestri M, Crisafulli C, Donato L, Giegling I, Calati R, Antypa N, et al. Nine differentially expressed genes from a post mortem study and their association with suicidal status in a sample of suicide completers, attempters and controls. J Psychiatr Res. 2017;91:98-104 pubmed publisher
    ..We focused on nine genes (S100A13, EFEMP1, PCDHB5, PDGFRB, CDCA7L, SCN2B, PTPRR, MLC1 and ZFP36) which we previously detected as differentially expressed in the cortex of suicide ..

More Information

Publications26

  1. Jiang Y, Wang W, Xie Q, Liu N, Liu L, Wang D, et al. Plants transfer lipids to sustain colonization by mutualistic mycorrhizal and parasitic fungi. Science. 2017;356:1172-1175 pubmed publisher
    ..The transfer is dependent on RAM2 (REQUIRED FOR ARBUSCULAR MYCORRHIZATION 2) and the ATP binding cassette transporter-mediated plant lipid export ..
  2. Pérez Ramírez M, Hernández Jiménez A, Guerrero Guerrero A, Siordia Reyes A, Hernández Caballero M, García Méndez A, et al. Pediatric pineal germinomas: Epigenetic and genomic approach. Clin Neurol Neurosurg. 2017;152:45-51 pubmed publisher
    ..We identified 1260 overexpressed genes and 470 underexpressed genes. The genes RUNDC3A, CDC247, CDCA7L, ASAH1, TRA2A, LPL and NPC2 were altered among the three levels. We identified the 1q24.2 and 1q31...
  3. Li N, Johnson D, Weinhold N, Studd J, Orlando G, Mirabella F, et al. Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression. Nat Commun. 2016;7:13656 pubmed publisher
    ..resides in an enhancer element 47?kb upstream of the transcription start site of c-Myc-interacting CDCA7L. The G-risk allele, associated with increased CDCA7L expression (P=1...
  4. Bravo A, Brands M, Wewer V, Dörmann P, Harrison M. Arbuscular mycorrhiza-specific enzymes FatM and RAM2 fine-tune lipid biosynthesis to promote development of arbuscular mycorrhiza. New Phytol. 2017;214:1631-1645 pubmed publisher
    ..root cells redirect lipid biosynthesis during AMS we analyzed the roles of two lipid biosynthetic enzymes (FatM and RAM2) and an ABC transporter (STR) that are required for symbiosis and conserved uniquely in plants that engage in AMS...
  5. Hendrix J, van Heertum B, Vanstreels E, Daelemans D, De Rijck J. Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin. J Biol Chem. 2014;289:12494-506 pubmed publisher
    ..and fluorescence correlation and cross-correlation spectroscopy to investigate in vivo chromatin binding of JPO2, a LEDGF/p75- and c-Myc-interacting protein involved in transcriptional regulation...
  6. Tian Y, Huang C, Zhang H, Ni Q, Han S, Wang D, et al. CDCA7L promotes hepatocellular carcinoma progression by regulating the cell cycle. Int J Oncol. 2013;43:2082-90 pubmed publisher
    The cell division cycle-associated 7-like protein (CDCA7L) is a recently-identified target gene of c-Myc which can also interact with c-Myc...
  7. Johnson S, Stockmeier C, Meyer J, Austin M, Albert P, Wang J, et al. The reduction of R1, a novel repressor protein for monoamine oxidase A, in major depressive disorder. Neuropsychopharmacology. 2011;36:2139-48 pubmed publisher
    The novel transcriptional repressor protein, R1 (JPO2/CDCA7L/RAM2), inhibits monoamine oxidase A (MAO A) gene expression and influences cell proliferation and survival...
  8. Ou X, Chen K, Shih J. Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1. J Biol Chem. 2006;281:21512-25 pubmed
    ..A novel transcription factor R1 (RAM2/CDCA7L) interacts with Sp1-binding sites and represses MAO A gene expression...
  9. Rich M, Courty P, Roux C, Reinhardt D. Role of the GRAS transcription factor ATA/RAM1 in the transcriptional reprogramming of arbuscular mycorrhiza in Petunia hybrida. BMC Genomics. 2017;18:589 pubmed publisher
    ..many AM-related genes, among them genes that are essential for the development of arbuscules, such as STR, STR2, RAM2, and PT4, besides hundreds of additional RAM1-dependent genes the role of which in symbiosis remains to be explored...
  10. Tesina P, Čermáková K, Hořejší M, Procházková K, Fábry M, Sharma S, et al. Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif. Nat Commun. 2015;6:7968 pubmed publisher
    ..Here we present structural characterization of IBD interactions with transcriptional repressor JPO2 and domesticated transposase PogZ, and show that the PogZ interaction is nearly identical to the interaction of ..
  11. Maertens G, Cherepanov P, Engelman A. Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin. J Cell Sci. 2006;119:2563-71 pubmed
    ..To gain insight into p75 function, we have characterized its cellular binding partners and report that JPO2, a recently identified Myc-binding protein, associates with p75 in vitro and in vivo...
  12. Greene W, Debyser Z, Ikeda Y, Freed E, Stephens E, Yonemoto W, et al. Novel targets for HIV therapy. Antiviral Res. 2008;80:251-65 pubmed publisher
  13. Bartholomeeusen K, De Rijck J, Busschots K, Desender L, Gijsbers R, Emiliani S, et al. Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75. J Mol Biol. 2007;372:407-21 pubmed
    ..By yeast-two-hybrid screening with a CEMC7 cDNA-library, we were able to identify JPO2 as a binding partner of the C-terminal part of LEDGF/p75...
  14. Weinhold N, Meissner T, Johnson D, Seckinger A, Moreaux J, Forsti A, et al. The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells. Haematologica. 2015;100:e110-3 pubmed publisher
  15. Chan T, Hawkins C, Krieger J, McGlade C, Huang A. JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma. Cancer Res. 2016;76:2802-12 pubmed publisher
    ..how Myc-PI3K/AKT signaling contributes to this malignancy, specifically, in identifying the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signaling and metastasis in ..
  16. Chen K, Ou X, Chen G, Choi S, Shih J. R1, a novel repressor of the human monoamine oxidase A. J Biol Chem. 2005;280:11552-9 pubmed
    ..A novel repressor, R1 (RAM2), has been cloned. The R1 cDNA encodes a protein with 454 amino acids and an open reading frame at the 5'-end...
  17. Ou X, Chen K, Shih J. Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. Proc Natl Acad Sci U S A. 2006;103:10923-8 pubmed
    ..We have previously reported that a novel transcription factor R1 (RAM2/CDCA7L/JPO2) inhibits the MAO A promoter and enzymatic activities...