Gene Symbol: CDC40
Description: cell division cycle 40
Alias: EHB3, PRP17, PRPF17, pre-mRNA-processing factor 17, EH-binding protein 3, PRP17 homolog, cell division cycle 40 homolog, hPRP17, pre-mRNA splicing factor 17
Species: human
Products:     CDC40

Top Publications

  1. Cappato S, Giacopelli F, Tonachini L, Ravazzolo R, Bocciardi R. Identification of reference genes for quantitative PCR during C3H10T1/2 chondrogenic differentiation. Mol Biol Rep. 2019;: pubmed publisher
    ..Among 12 candidate reference genes (Ap3d1, Csnk2a2, Cdc40, Fbxw2, Fbxo38, Htatsf1, Mon2, Pak1ip1, Zfp91, 18S, ActB, GAPDH) we identified Mon2 and Ap3d1 as the most stable ..
  2. Wang K, Ma J, Zhang F, Yu M, Xue J, Zhao J. MicroRNA-378 inhibits cell growth and enhances L-OHP-induced apoptosis in human colorectal cancer. IUBMB Life. 2014;66:645-54 pubmed publisher
    ..Bioinformatics analysis further deduced that CDC40 is a potential target of miR-378, and luciferase reporter assays confirmed the direct regulation of CDC40 by miR-..
  3. Yan C, Wan R, Bai R, Huang G, Shi Y. Structure of a yeast step II catalytically activated spliceosome. Science. 2017;355:149-155 pubmed publisher
    ..Prp8 (the 1585 loop and the ? finger of the ribonuclease H-like domain), along with the step II splicing factors Prp17 and Prp18 and other surrounding proteins, are poised to assist the second transesterification...
  4. Zhang X, Yan C, Hang J, Finci L, Lei J, Shi Y. An Atomic Structure of the Human Spliceosome. Cell. 2017;169:918-929.e14 pubmed publisher
    ..76 Å. The splicing factor Prp17 stabilizes the active site conformation...
  5. Bertram K, Agafonov D, Liu W, Dybkov O, Will C, Hartmuth K, et al. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature. 2017;542:318-323 pubmed publisher
    ..position close to the U6 small nuclear RNA ACAGA box is stabilized by interactions with the PRP8 RNase H-like and PRP17 WD40 domains...
  6. Fica S, Oubridge C, Galej W, Wilkinson M, Bai X, Newman A, et al. Structure of a spliceosome remodelled for exon ligation. Nature. 2017;542:377-380 pubmed publisher
    ..both steps, the branch helix has rotated by 75° compared to the C complex and is stabilized in a new position by Prp17, Cef1 and the reoriented Prp8 RNase H-like domain...
  7. Kuang X, Wei C, Zhang T, Yang Z, Chi J, Wang L. miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes. Int J Oncol. 2016;49:1921-1930 pubmed publisher
    ..cell cycle arrest, and suppressive effect of miR-378 on MDS/AML cells may be mediated partly through Bcl-w and CDC40. Moreover, apoptosis induced by miR-378 correlated with increased expression of Bax and activation of caspase-3, -..
  8. Kong X, Lv Y, Shao L, Nong X, Zhang G, Zhang Y, et al. HBx-induced MiR-1269b in NF-?B dependent manner upregulates cell division cycle 40 homolog (CDC40) to promote proliferation and migration in hepatoma cells. J Transl Med. 2016;14:189 pubmed publisher
    ..miR-1269b targets and up-regulates CDC40, a cell division cycle 40 homolog. CDC40 increases cell cycle progression, cell proliferation and migration...
  9. Wan R, Yan C, Bai R, Lei J, Shi Y. Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae. Cell. 2017;171:120-132.e12 pubmed publisher
    ..The step II splicing factors Prp17 and Prp18, along with Cwc21 and Cwc22 that stabilize the 5' exon binding to loop I of U5 small nuclear RNA (snRNA),..

More Information


  1. Wong W, Schumacher C, Salcini A, Romano A, Castagnino P, Pelicci P, et al. A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. Proc Natl Acad Sci U S A. 1995;92:9530-4 pubmed
    ..Structural comparison of Eps15 and Eps15r defines a family of signal transducers possessing extensive networking abilities including EH-mediated binding and association with Src homology 3-containing proteins. ..
  2. Miyaki M, Yamaguchi T, Iijima T, Takahashi K, Matsumoto H, Mori T. Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors. Oncology. 2009;76:430-4 pubmed publisher
    ..Moreover, infrequent LOH suggests that the CDC4 gene does not follow the general 2-hit model. ..
  3. Lindsey L, Garcia Blanco M. Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p. J Biol Chem. 1998;273:32771-5 pubmed
    ..Human hPrp17, which is 35% identical to the S...
  4. Ben Yehuda S, Dix I, Russell C, McGarvey M, Beggs J, Kupiec M. Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. Genetics. 2000;156:1503-17 pubmed
    The PRP17/CDC40 gene of Saccharomyces cerevisiae functions in two different cellular processes: pre-mRNA splicing and cell cycle progression...
  5. Ben Yehuda S, Dix I, Russell C, Levy S, Beggs J, Kupiec M. Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control. RNA. 1998;4:1304-12 pubmed
    ..We show that a yeast-human chimera, carrying the C-terminal two thirds of the hPRP17 protein, is able to complement the cell cycle and splicing defects of a yeast prp17 mutant...
  6. Zhou Z, Reed R. Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. EMBO J. 1998;17:2095-106 pubmed
    ..Recently, the human homologs of Prp18 and Slu7 were identified. The observation that humans contain homologs of all four known step II proteins in yeast indicates that the mechanism for catalytic step II is highly conserved. ..
  7. Liu Y, Wei B, Zhang X, Xu D, Wang B, Yin G, et al. Identification of potential therapeutic target genes and miRNAs for primary myelofibrosis with microarray analysis. Exp Ther Med. 2017;14:2743-2750 pubmed publisher
    ..For downregulated genes, certain DEGs were enriched in the spliceosome, including SF3B1 and CDC40...
  8. Salcini A, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, et al. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Genes Dev. 1997;11:2239-49 pubmed
    ..Based on the characteristics of EH-containing and EH-binding proteins, we propose that EH domains are involved in processes connected with the transport and sorting of molecules within the cell. ..