cdc25C

Summary

Gene Symbol: cdc25C
Description: cell division cycle 25C
Alias: CDC25, PPP1R60, M-phase inducer phosphatase 3, dual specificity phosphatase CDC25C, mitosis inducer CDC25, phosphotyrosine phosphatase, protein phosphatase 1, regulatory subunit 60
Species: human
Products:     cdc25C

Top Publications

  1. Ozen M, Ittmann M. Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer. Clin Cancer Res. 2005;11:4701-6 pubmed
    ..b>CDC25C plays an important role in the G2-M transition by activating Cdc2/Cyclin B1 complexes...
  2. Bureik M, Rief N, Drescher R, Jungbluth A, Montenarh M, Wagner P. An additional transcript of the cdc25C gene from A431 cells encodes a functional protein. Int J Oncol. 2000;17:1251-8 pubmed
    ..Overexpression of cdc25C phosphatase, the mitotic activator of cdc2, results in suppression of a p53-induced growth arrest...
  3. Hernandez S, Bessa X, Bea S, Hernandez L, Nadal A, Mallofre C, et al. Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma. Lab Invest. 2001;81:465-73 pubmed
    b>cdc25 is a family of cell-cycle phosphatases that activate the cyclin-dependent kinases. cdc25A and B, but not C, have oncogenic potential in vitro...
  4. Chen F, Zhang Z, Bower J, Lu Y, Leonard S, Ding M, et al. Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A. 2002;99:1990-5 pubmed
    ..arrested the cell cycle at G(2)/M phase, partially through induction of cell division cycle 25 (Cdc25) isoform C (Cdc25C) degradation via ubiquitin-proteasome pathways...
  5. Graves P, Yu L, Schwarz J, Gales J, Sausville E, O Connor P, et al. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem. 2000;275:5600-5 pubmed
    ..The checkpoint kinases, Chk1 and Cds1, are proposed to regulate the interactions between human Cdc25C and 14-3-3 proteins by phosphorylating Cdc25C on serine 216...
  6. Strausfeld U, Labbe J, Fesquet D, Cavadore J, Picard A, Sadhu K, et al. Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature. 1991;351:242-5 pubmed
    ..The phosphatase(s) involved in p34cdc2 dephosphorylation is unknown, but the product of the fission yeast cdc25+ gene, and its homologues in budding yeast and Drosophila are probably positive regulators of the transition from ..
  7. Strausfeld U, Fernandez A, Capony J, Girard F, Lautredou N, Derancourt J, et al. Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. J Biol Chem. 1994;269:5989-6000 pubmed
    Human cdc25C protein, a specific tyrosine phosphatase that activates the p34cdc2 protein kinase at mitosis, is itself a phosphoprotein that shows increased phosphorylation during the G2-M transition...
  8. Busch C, Barton O, Morgenstern E, Götz C, Günther J, Noll A, et al. The G2/M checkpoint phosphatase cdc25C is located within centrosomes. Int J Biochem Cell Biol. 2007;39:1707-13 pubmed
    b>cdc25C is a phosphatase which regulates the activity of the mitosis promoting factor cyclin B/cdk1 by dephosphorylation, thus triggering G(2)/M transition...
  9. Forester C, Maddox J, Louis J, Goris J, Virshup D. Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. Proc Natl Acad Sci U S A. 2007;104:19867-72 pubmed
    ..Cdk1 activity is controlled by the Cdc25C phosphatase, which is turned on at the G(2)/M transition to catalyze Cdk1 activation...

More Information

Publications85

  1. Wang R, He G, Nelman Gonzalez M, Ashorn C, Gallick G, Stukenberg P, et al. Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell. 2007;128:1119-32 pubmed
    ..In a mammalian cell line, ERK1/2 interacts with Cdc25C in interphase and phosphorylates Cdc25C at T48 in mitosis...
  2. Margolis S, Perry J, Forester C, Nutt L, Guo Y, Jardim M, et al. Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell. 2006;127:759-73 pubmed
    ..The mitotic activator Cdc25 is suppressed by checkpoints through inhibitory phosphorylation at Ser287 (Xenopus numbering) and docking of 14-3-..
  3. Galaktionov K, Beach D. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell. 1991;67:1181-94 pubmed
    Two previously unidentified human cdc25 genes have been isolated, cdc25A and cdc25B. Both genes rescue a cdc25ts mutant of fission yeast. Microinjection of anti-cdc25A antibodies into HeLa cells causes their arrest in mitosis...
  4. Zannini L, Lecis D, Lisanti S, Benetti R, Buscemi G, Schneider C, et al. Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import. J Biol Chem. 2003;278:42346-51 pubmed
    ..Finally, co-transfection experiments with green fluorescent protein (GFP)-Chk2 and wild type or mutant KPNA-2 confirmed the role of KPNA-2 in nuclear import of Chk2. ..
  5. Bulavin D, Higashimoto Y, Demidenko Z, Meek S, Graves P, Phillips C, et al. Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol. 2003;5:545-51 pubmed
    Negative regulation of the Cdc25C protein phosphatase by phosphorylation on Ser 216, the 14-3-3-binding site, is an important regulatory mechanism used by cells to block mitotic entry under normal conditions and after DNA damage...
  6. Toyoshima Morimoto F, Taniguchi E, Nishida E. Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep. 2002;3:341-8 pubmed
    ..The protein phosphatase Cdc25C, an activator of MPF, enters the nucleus to keep MPF active in the nucleus during prophase...
  7. Kawabe T, Suganuma M, Ando T, Kimura M, Hori H, Okamoto T. Cdc25C interacts with PCNA at G2/M transition. Oncogene. 2002;21:1717-26 pubmed
    ..In this study, we searched the interacting protein(s) of human Cdc25C using the yeast two-hybrid screen and identified proliferating cell nuclear antigen (PCNA) as an interacting ..
  8. Bonnet J, Mayonove P, Morris M. Differential phosphorylation of Cdc25C phosphatase in mitosis. Biochem Biophys Res Commun. 2008;370:483-8 pubmed publisher
    ..Activation of Cdc25C at the G2/M transition, involves its dissociation from 14-3-3, together with its hyperphosphorylation on several ..
  9. Varmeh S, Manfredi J. Overexpression of the dual specificity phosphatase, Cdc25C, confers sensitivity on tumor cells to doxorubicin-induced cell death. Mol Cancer Ther. 2008;7:3789-99 pubmed publisher
    b>Cdc25C is a dual-specificity phosphatase that is involved in induction of mitosis by removal of the inhibitory phosphates from cyclin-dependent kinase 1/cyclin B...
  10. Re F, Braaten D, Franke E, Luban J. Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. J Virol. 1995;69:6859-64 pubmed
    ..Low cyclin B-associated kinase activity, as well as the status of p34cdc2 and cdc25C phosphorylation, indicates that the cascade of reactions which drives the cell into mitosis has not been initiated...
  11. Di Marzio P, Choe S, Ebright M, Knoblauch R, Landau N. Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. J Virol. 1995;69:7909-16 pubmed
    ..We speculate that Vpr has two sites for interaction with cellular factors: one in the alpha-helical region that specifies nuclear localization and one in the carboxy-terminal domain that is required for Cdc2 inhibition. ..
  12. Wegener S, Hampe W, Herrmann D, Schaller H. Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. Eur J Cell Biol. 2000;79:810-5 pubmed
    ..We identified four new splice variants in the amino-terminal regulatory region of human cdc25C and one in cdc25A. All variants except one retain an intact catalytic domain...
  13. Nilsson I, Hoffmann I. Cell cycle regulation by the Cdc25 phosphatase family. Prog Cell Cycle Res. 2000;4:107-14 pubmed
    ..cells can be achieved through dephosphorylation by members of the Cdc25 phosphatase family, Cdc25A, Cdc25B and Cdc25C. Cdc25A plays an important role at the G1/S-phase transition...
  14. Lopez Girona A, Furnari B, Mondesert O, Russell P. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature. 1999;397:172-5 pubmed
    ..The protein Chk1 enforces this checkpoint by phosphorylating the mitotic inducer Cdc25. Phosphorylation of Cdc25 by Chk1 creates a binding site in Cdc25 for 14-3-3 proteins, but it is not known how 14-..
  15. Peng C, Graves P, Thoma R, Wu Z, Shaw A, Piwnica Worms H. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science. 1997;277:1501-5 pubmed
    Human Cdc25C is a dual-specificity protein phosphatase that controls entry into mitosis by dephosphorylating the protein kinase Cdc2...
  16. Roshak A, Capper E, Imburgia C, Fornwald J, Scott G, Marshall L. The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. Cell Signal. 2000;12:405-11 pubmed
    ..This is accomplished by the specific dephosphorylation of key residues by the cdc25C phosphatase...
  17. Sanchez Y, Wong C, Thoma R, Richman R, Wu Z, Piwnica Worms H, et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 1997;277:1497-501 pubmed
    ..In vitro Chk1 bound to and phosphorylated the dual-specificity protein phosphatases Cdc25A, Cdc25B, and Cdc25C, which control cell cycle transitions by dephosphorylating cyclin-dependent kinases...
  18. Sadhu K, Reed S, Richardson H, Russell P. Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Proc Natl Acad Sci U S A. 1990;87:5139-43 pubmed
    ..We have cloned a human gene, which we call CDC25, whose product may function as a mitotic inducer...
  19. Eymin B, Claverie P, Salon C, Brambilla C, Brambilla E, Gazzeri S. p14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation. Cell Cycle. 2006;5:759-65 pubmed
    The Cdc25C phosphatase is a key regulator of mitotic entry which activity is tightly regulated by phosphorylation. In response to DNA damage, phosphorylation at serine 216 induces the cytosolic retention of Cdc25C through 14-3-3 binding...
  20. Bonnet J, Coopman P, Morris M. Characterization of centrosomal localization and dynamics of Cdc25C phosphatase in mitosis. Cell Cycle. 2008;7:1991-8 pubmed
    ..Whereas Cdc25B is believed to trigger entry into mitosis, Cdc25C is thought to act at a later stage of mitosis and in the nucleus...
  21. Kino T, Gragerov A, Valentin A, Tsopanomihalou M, Ilyina Gragerova G, Erwin Cohen R, et al. Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest. J Virol. 2005;79:2780-7 pubmed
    ..14-3-3 proteins regulate the G(2)/M transition by inactivating Cdc25C phosphatase via binding to the phosphorylated serine residue at position 216 of Cdc25C...
  22. Timofeev O, Cizmecioglu O, Settele F, Kempf T, Hoffmann I. Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition. J Biol Chem. 2010;285:16978-90 pubmed publisher
    ..Consistent with this observation, we demonstrate that in human transformed cells, Cdc25A and Cdc25B, but not Cdc25C phosphatases have an effect on timing and efficiency of cyclin-kinase complex formation...
  23. Bahassi E, Hennigan R, Myer D, Stambrook P. Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. Oncogene. 2004;23:2658-63 pubmed
    ..occurs by dephosphorylation of the inhibitory residues, threonine 14 (T14) and tyrosine 15 (Y15), on Cdc2 by the Cdc25C phosphatase...
  24. Elia A, Rellos P, Haire L, Chao J, Ivins F, Hoepker K, et al. The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell. 2003;115:83-95 pubmed
    ..In addition, phosphopeptide binding to the PBD stimulates kinase activity in full-length Plk1, suggesting a conformational switching mechanism for Plk regulation and a dual functionality for the PBD. ..
  25. Wei S, Chen X, Rocha K, Epling Burnette P, Djeu J, Liu Q, et al. A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide. Proc Natl Acad Sci U S A. 2009;106:12974-9 pubmed publisher
    ..We show that the dual specificity phosphatases, Cdc25C and PP2Acalpha, which are coregulators of the G(2)-M checkpoint, are inhibited by lenalidomide...
  26. Turowski P, Franckhauser C, Morris M, Vaglio P, Fernandez A, Lamb N. Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells. Mol Biol Cell. 2003;14:2984-98 pubmed
    In view of the common regulatory mechanism that induces transcription of the mitotic phosphatase cdc25C and cyclin A at the beginning of S-phase, we investigated whether cdc25C was required for S-phase transit...
  27. Elia A, Cantley L, Yaffe M. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science. 2003;299:1228-31 pubmed
    ..This motif is present in known Plk1 substrates such as Cdc25, and an optimal phosphopeptide containing the motif disrupted PBD-substrate binding and localization of the PBD to ..
  28. Takizawa C, Morgan D. Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Curr Opin Cell Biol. 2000;12:658-65 pubmed
    ..Recent work has unveiled many of the mechanisms that govern the localization of cyclin-B1-Cdk1 and its regulator Cdc25C. Phosphorylation-dependent changes in the rate of nuclear import and export of these proteins help to control the ..
  29. Zhang Q, Zhang F, Thakur K, Wang J, Wang H, Hu F, et al. Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells. Food Chem Toxicol. 2018;112:466-475 pubmed publisher
    ..was accompanied by the increase in mRNA expression of p53, p21 and Wee 1 genes and decreased levels of CDK1, Cdc25c, Survivin, cyclin B1and CHK2...
  30. Keifenheim D, Sun X, D Souza E, Ohira M, Magner M, Mayhew M, et al. Size-Dependent Expression of the Mitotic Activator Cdc25 Suggests a Mechanism of Size Control in Fission Yeast. Curr Biol. 2017;27:1491-1497.e4 pubmed publisher
    ..pombe is regulated by a third strategy: the size-dependent expression of the mitotic activator Cdc25. cdc25 transcript levels are regulated such that smaller cells express less Cdc25 and larger cells express more ..
  31. Popovic M, Schouten A, Rensen de Leeuw M, Rehmann H. The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity. J Struct Biol. 2016;193:106-14 pubmed publisher
    b>CDC25 homology domain (CDC25-HD) containing Guanine Nucleotide Exchange Factors (GEFs) initiate signalling by small G-proteins of the Ras-family...
  32. Gu P, Chen X, Xie R, Han J, Xie W, Wang B, et al. lncRNA HOXD-AS1 Regulates Proliferation and Chemo-Resistance of Castration-Resistant Prostate Cancer via Recruiting WDR5. Mol Ther. 2017;25:1959-1973 pubmed publisher
    ..identified several cell cycle, chemo-resistance, and castration-resistance-related genes, including PLK1, AURKA, CDC25C, FOXM1, and UBE2C, that were activated transcriptionally by HOXD-AS1...
  33. Jayasooriya R, Molagoda I, Park C, Jeong J, Choi Y, Moon D, et al. Molecular chemotherapeutic potential of butein: A concise review. Food Chem Toxicol. 2018;112:1-10 pubmed publisher
    ..with increased phosphorylation of ataxia telangiectasia mutated (ATM) and Chk1/2, and consequently, with reduced cdc25C levels...
  34. Yu L, Ma J, Han J, Wang B, Chen X, Gao C, et al. Licochalcone B Arrests Cell Cycle Progression and Induces Apoptosis in Human Breast Cancer MCF-7 Cells. Recent Pat Anticancer Drug Discov. 2016;11:444-452 pubmed
    ..arrest in MCF-7 cells, which could be elucidated by the decreased mRNA and protein levels of Cyclin A, Cdk2 and Cdc25 A, and the increased protein level of p21...
  35. Lee Y, Son M, Kim J, Shim Y, Kawasaki I. CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions. Cell Cycle. 2016;15:654-66 pubmed publisher
    ..Here, we report that CDC-25.2, a C. elegans ortholog of Cdc25, is required for these specialized division cycles between the 16E cell stage and the onset of endoreduplication...
  36. Cunat S, Anahory T, Berthenet C, Hedon B, Franckhauser C, Fernandez A, et al. The cell cycle control protein cdc25C is present, and phosphorylated on serine 214 in the transition from germinal vesicle to metaphase II in human oocyte meiosis. Mol Reprod Dev. 2008;75:1176-84 pubmed
    b>Cdc25C is a dual specificity phosphatase essential for dephosphorylation and activation of cyclin-dependent kinase 1 (cdk1), a prerequisite step for mitosis in all eucaryotes...
  37. Zhang R, Zhu L, Zhang L, Xu A, Li Z, Xu Y, et al. PTEN enhances G2/M arrest in etoposide-treated MCF?7 cells through activation of the ATM pathway. Oncol Rep. 2016;35:2707-14 pubmed publisher
    ..kinase ataxia telangiectasia mutated (ATM), followed by the activation of Chk2 that subsequently inactivates CDC25C, resulting in G2/M arrest...
  38. Cheng A, Gerry S, Kaldis P, Solomon M. Biochemical characterization of Cdk2-Speedy/Ringo A2. BMC Biochem. 2005;6:19 pubmed
    ..Cdk2-Speedy/Ringo A2 also phosphorylated authentic Cdk2 substrates, such as Cdc25 proteins, which contain non-canonical CDK phosphorylation sites, nearly as well as Cdk2-cyclin A...
  39. Ding W, Hu Z, Zhang Z, Ma Q, Tang H, Ma Z. Physapubescin B Exhibits Potent Activity against Human Prostate Cancer In Vitro and In Vivo. J Agric Food Chem. 2015;63:9504-12 pubmed publisher
    ..with physapubescin B resulted in the accumulation of cells in the G2/M phase, which was associated with reduced Cdc25C levels and increased levels of CyclinB1, P21 as well as p-Cdk1 (Tyr15)...
  40. Crenshaw D, Yang J, Means A, Kornbluth S. The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. EMBO J. 1998;17:1315-27 pubmed
    ..of Pin1 interaction with critical upstream regulators of Cdc2/cyclin B, including the Cdc2-directed phosphatase, Cdc25, and its known regulator, Plx1...
  41. Broggini T, Schnell L, Ghoochani A, Mateos J, Buchfelder M, Wiendieck K, et al. Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury. Aging (Albany NY). 2016;8:2463-2487 pubmed publisher
    ..The neurite growth promoting activity of PRG3 requires RasGRF1 (RasGEF1/Cdc25) mediated downstream signaling...
  42. Beillerot A, Battaglia E, Bennasroune A, Bagrel D. Protection of CDC25 phosphatases against oxidative stress in breast cancer cells: evaluation of the implication of the thioredoxin system. Free Radic Res. 2012;46:674-89 pubmed publisher
    Reactive oxygen species regulate protein functionality. Cell cycle CDC25 phosphatases are targets of such oxidative regulation in vitro...
  43. Zhao B, Keasey S, Tropea J, Lountos G, Dyas B, Cherry S, et al. Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. PLoS ONE. 2015;10:e0134984 pubmed publisher
    ..four types: MAP kinases (DUSP1 and DUSP7), atypical (DUSP3, DUSP14, DUSP22 and DUSP27), viral (variola VH1), and Cdc25 (A-C)...
  44. Moris N, Shrivastava J, Jeffery L, Li J, Hayles J, Nurse P. A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast. Cell Cycle. 2016;15:3121-3130 pubmed
    ..These included mutants of the cdc2, cdc25, wee1 and pom1 genes, which have previously been shown to play a role in the timing of entry into mitosis, and ..
  45. Huang Z, Zhou X, He Y, Ke X, Wen Y, Zou F, et al. Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition. Sci Rep. 2016;6:38072 pubmed publisher
    ..Heat shock/17-DMAG co-treatment of HCC cells also destabilized CDK1, Cyclin B1 and CDC25C with a concomitant decreased proportion of cells in the M phase...
  46. Shi H, Li Y, Ren X, Zhang Y, Yang Z, Qi C. A novel quinazoline-based analog induces G2/M cell cycle arrest and apoptosis in human A549 lung cancer cells via a ROS-dependent mechanism. Biochem Biophys Res Commun. 2017;486:314-320 pubmed publisher
    ..This caused up-regulation of p53-inducible p21 and down-regulation of redox sensitive Cdc25C along with Cyclin B1/Cdk1, leading to a G2/M cell cycle arrest and final cell apoptosis...
  47. Chatterjee S, Huang E, Christie I, Burns T. Reactivation of the p90RSK-CDC25C Pathway Leads to Bypass of the Ganetespib-Induced G2-M Arrest and Mediates Acquired Resistance to Ganetespib in KRAS-Mutant NSCLC. Mol Cancer Ther. 2017;16:1658-1668 pubmed publisher
    ..Reactivation of p90RSK and its downstream target, CDC25C, was critical for GR and mediated the bypass of a G2-M arrest...
  48. Chen F, Jin X, Zhao J, Gou S. DN604: A platinum(II) drug candidate with classic SAR can induce apoptosis via suppressing CK2-mediated p-cdc25C subcellular localization in cancer cells. Exp Cell Res. 2018;364:68-83 pubmed publisher
    ..The mechanism study indicated that DN604 inhibited CK2-phosphorylated cdc25C activation to decrease p-cdc25C subcellular localization, leading to the inactivation of cdc2/Cyclin B and G2/M ..
  49. Sarkis M, Miteva M, Dasso Lang M, Jaouen M, Sari M, Galcera M, et al. Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25. Proteins. 2017;85:593-601 pubmed publisher
    b>CDC25 phosphatases play a crucial role in cell cycle regulation. They have been found to be over-expressed in various human tumours and to be valuable targets for cancer treatment...
  50. Chiang K, Chen H, Hsu S, Pang J, Wang S, Hsu J, et al. PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo. Drug Des Devel Ther. 2015;9:4631-8 pubmed publisher
    ..blot demonstrated that p27 was repressed obviously with p21 slightly inhibited and CDK1, 2, 4, 6, cyclin A, and Cdc25C were upregulated in MCF-7 PTEN knockdown cells, leading to the higher growth rate...
  51. Heo J, Song J, Jeong J, Kim G, Kim T, Kang H, et al. Fibulin-5 is a tumour suppressor inhibiting cell migration and invasion in ovarian cancer. J Clin Pathol. 2016;69:109-16 pubmed publisher
    ..Overexpression of fibulin-5 induced G2/M arrest and increased cyclin B1, CDC2 and CDC25C. Expression of TIMP-2 (0.56-fold), MMP-3 (0.43-fold) and MMP-13 (0.18-fold) was lower and MMP-9 expression (2...
  52. Li Q, Hsu I, Sanford T, Railkar R, Balaji N, Sourbier C, et al. Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M. Cell Mol Life Sci. 2018;75:939-963 pubmed publisher
    ..Moreover, CRT0066101 downregulated the expression of Cdc25C, which dephosphorylates/activates CDK1, but enhanced the activity of the checkpoint kinase Chk1, which inhibits ..
  53. Huber Villaume S, Revelant G, Sibille E, Philippot S, Morabito A, Dunand S, et al. 2-(Thienothiazolylimino)-1,3-thiazolidin-4-ones inhibit cell division cycle 25 A phosphatase. Bioorg Med Chem. 2016;24:2920-2928 pubmed publisher
    Cell division cycle dual phosphatases (CDC25) are essential enzymes that regulate cell progression in cell cycle. Three isoforms exist as CDC25A, B and C. Over-expression of each CDC25 enzyme is found in cancers of diverse origins...
  54. Huard S, Elder R, Liang D, Li G, Zhao R. Human immunodeficiency virus type 1 Vpr induces cell cycle G2 arrest through Srk1/MK2-mediated phosphorylation of Cdc25. J Virol. 2008;82:2904-17 pubmed
    ..Our previous studies in fission yeast demonstrated that Vpr induces G(2) arrest in part through inhibition of Cdc25, a Cdc2-specific phosphatase that promotes G(2)/M transition...
  55. Perner F, Schnöder T, Fischer T, Heidel F. Kinomics Screening Identifies Aberrant Phosphorylation of CDC25C in FLT3-ITD-positive AML. Anticancer Res. 2016;36:6249-6258 pubmed
    ..We identified aberrant phosphorylation of CDC25C-T48 in FLT3-ITD mutated cells...
  56. Zheng X, Ruderman J. Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25. Cell. 1993;75:155-64 pubmed
    ..phosphorylations on Thr-14 and Tyr-15 of cdc2 until they are dephosphorylated at the end of G2 by the phosphatase cdc25. Recent work has suggested that a small region of cyclin B, which we call the P box, may contribute part of a ..
  57. Draetta G, Eckstein J. Cdc25 protein phosphatases in cell proliferation. Biochim Biophys Acta. 1997;1332:M53-63 pubmed
  58. Shen H, Wang H, Wang L, Wang L, Zhu M, Ming Y, et al. Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression. Evid Based Complement Alternat Med. 2017;2017:8231936 pubmed publisher
    ..The expression of mitosis-related protein Cdc25c was impaired upon TSG treatment...
  59. Pilling C, Cooper J. SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms. Sci Rep. 2017;7:10838 pubmed publisher
    ..domain and EphA2 activation loop autophosphorylation, which is stimulated by Ephrin A1 (EfnA1) or by phosphotyrosine phosphatase inhibition...
  60. Jin P, Hardy S, Morgan D. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J Cell Biol. 1998;141:875-85 pubmed
    ..Thus, nuclear targeting of cyclin B1 and dephosphorylation of Cdc2 both contribute to the control of mitotic entry and exit in human cells. ..
  61. Chen J. Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. Cancer Res. 2000;60:5037-9 pubmed
    ..Taken together, these results suggest that ATR directly phosphorylates BRCA1 following DNA damage. ..
  62. Ichimura T, Wakamiya Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, et al. Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein. Biochemistry. 2002;41:5566-72 pubmed
    ..These data add KLC2 to the growing list of 14-3-3 targets, and suggest a role of 14-3-3 in the phosphorylation-regulated cellular transport of vesicles and organelles. ..
  63. Olson E, Nievera C, Klimovich V, Fanning E, Wu X. RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. J Biol Chem. 2006;281:39517-33 pubmed
    ..Our studies suggest that in response to UV-induced DNA damage, ATR rapidly phosphorylates RPA2, disrupting its association with replication centers in the S-phase and contributing to the inhibition of DNA replication. ..
  64. Noll A, Ruppenthal S, Montenarh M. The mitotic phosphatase cdc25C at the Golgi apparatus. Biochem Biophys Res Commun. 2006;351:825-30 pubmed
    b>cdc25C is a phosphatase which regulates the activity of the mitosis promoting factor cyclin B/cdk1 by dephosphorylation, thus triggering G(2)/M transition...
  65. Smith Donald B, Durand L, Roizman B. Role of cellular phosphatase cdc25C in herpes simplex virus 1 replication. J Virol. 2008;82:4527-32 pubmed publisher
    ..Activation of cdc2, the first step in the process, is a key function of the mitotic phosphatase cdc25C. To define the role of cdc25C, we probed some features of the ICP22-dependent pathway of upregulation of gamma(2) ..
  66. Bhattacharjee H, Sheng J, Ajees A, Mukhopadhyay R, Rosen B. Adventitious arsenate reductase activity of the catalytic domain of the human Cdc25B and Cdc25C phosphatases. Biochemistry. 2010;49:802-9 pubmed publisher
    ..of eukaryotic enzymes that function as arsenate reductases are homologues of the catalytic domain of the human Cdc25 phosphatase...
  67. Moon D, Kim M, Nam T, Kim S, Choi Y, Kim G. Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C. Oncol Rep. 2010;24:271-6 pubmed
    ..G2/M phase arrest through down-regulation of cyclin B1 and cdc2 expression, but also through phosphorylation of cdc25C. We found increased phosphorylation of ATM and Chk1/2 in a PTX-2 dose-dependent manner...
  68. Natarajan S, Begum F, Gim J, Wark L, Henderson D, Davie J, et al. High Mobility Group A2 protects cancer cells against telomere dysfunction. Oncotarget. 2016;7:12761-82 pubmed publisher
    ..prevented ATM-dependent pTRF2T188 phosphorylation and attenuated signaling via the telomere specific ATM-CHK2-CDC25C DNA damage signaling axis...
  69. Tumurbaatar I, Cizmecioglu O, Hoffmann I, Grummt I, Voit R. Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. PLoS ONE. 2011;6:e14711 pubmed publisher
    ..Unscheduled overexpression of hCdc14B delays activation of two master regulators of mitosis, Cdc25 and Cdk1, and slows down entry into mitosis...
  70. Zhao Y, Cui Y, Han J, Ren J, Wu G, Cheng J. Cell division cycle 25 homolog c effects on low-dose hyper-radiosensitivity and induced radioresistance at elevated dosage in A549 cells. J Radiat Res. 2012;53:686-94 pubmed publisher
    ..levels, remain unclear; however, elucidation of the relationship between cell cycle division 25 homolog c (Cdc25c) phosphatase and HRS/IRR may provide important insights into this process...
  71. Shabbeer S, Omer D, Berneman D, Weitzman O, Alpaugh A, Pietraszkiewicz A, et al. BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation. Oncogene. 2013;32:5005-16 pubmed publisher
    ..We present data showing that BRCA1 ubiquitinates G2/M cell cycle proteins, cyclin B and Cdc25C, leading to their accelerated degradation via a mechanism that is independent of APC/C...
  72. Ruppenthal S, Noll A, Götz C, Montenarh M. Interference between p53 and cdc25C in cell cycle regulation. Int J Oncol. 2007;31:345-52 pubmed
    ..of human p53 led to growth arrest of yeast cells which can be suppressed by simultaneous overexpression of cdc25C, a phosphatase regulating entry into mitosis...
  73. Andersen J, Planelles V. The role of Vpr in HIV-1 pathogenesis. Curr HIV Res. 2005;3:43-51 pubmed
    ..This review presents the latest findings about the pathogenic events triggered by Vpr, the cellular pathways involved, and the molecular and cellular consequences of the action of Vpr in the context of HIV-1 infection. ..
  74. Xie S, Wu H, Wang Q, Cogswell J, Husain I, Conn C, et al. Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. J Biol Chem. 2001;276:43305-12 pubmed
    ..Stambrook, P., Li, B., and Dai, W. (1997) J. Biol. Chem. 272, 28646-28651). Plk3 physically interacts with Cdc25C and phosphorylates this protein phosphatase predominantly on serine 216 (Ouyang, B., Li, W., Pan, H., Meadows, J...
  75. Dedobbeleer M, Willems E, Freeman S, Lombard A, Goffart N, Rogister B. Phosphatases and solid tumors: focus on glioblastoma initiation, progression and recurrences. Biochem J. 2017;474:2903-2924 pubmed publisher
    ..The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ..
  76. Brenner A, Reikvam H, Lavecchia A, Bruserud Ø. Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms. Molecules. 2014;19:18414-47 pubmed publisher
    The cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C. These three molecules are important regulators of several steps in the cell cycle, including the activation of various cyclin-dependent kinases (CDKs)...