CDC25B

Summary

Gene Symbol: CDC25B
Description: cell division cycle 25B
Alias: M-phase inducer phosphatase 2, dual specificity phosphatase Cdc25B
Species: human
Products:     CDC25B

Top Publications

  1. Strausfeld U, Labbe J, Fesquet D, Cavadore J, Picard A, Sadhu K, et al. Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature. 1991;351:242-5 pubmed
    ..We propose that the cdc25+ gene product directly activates the p34cdc2-cyclin B complex. ..
  2. Baldin V, Cans C, Superti Furga G, Ducommun B. Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control?. Oncogene. 1997;14:2485-95 pubmed
    CDC25B2, a protein tyrosine phosphatase closely related to the putative CDC25B oncogene, was identified in a Burkitt lymphoma cDNA library...
  3. Booher R, Holman P, Fattaey A. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. J Biol Chem. 1997;272:22300-6 pubmed
    ..These findings suggest that human Myt1 is negatively regulated by an M phase-activated kinase and that Myt1 inhibits mitosis due to its specificity for Cdc2.cyclin complexes. ..
  4. Karlsson C, Katich S, Hagting A, Hoffmann I, Pines J. Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis. J Cell Biol. 1999;146:573-84 pubmed
    We have used time-lapse fluorescence microscopy to study the properties of the Cdc25B and Cdc25C phosphatases that have both been implicated as initiators of mitosis in human cells...
  5. Theis Febvre N, Filhol O, Froment C, Cazales M, Cochet C, Monsarrat B, et al. Protein kinase CK2 regulates CDC25B phosphatase activity. Oncogene. 2003;22:220-32 pubmed
    ..suspected involvement of the protein kinase CK2 at the G2/M transition, we have investigated its effects on the CDC25B phosphatase. We show that in vitro CK2 phosphorylates CDC25B, but not CDC25C...
  6. Mirey G, Chartrain I, Froment C, Quaranta M, Bouché J, Monsarrat B, et al. CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. Cell Cycle. 2005;4:806-11 pubmed
    The phosphatase CDC25B is one of the key regulators that control entry into mitosis through the dephosphorylation and subsequent activation of the cyclin-dependent kinases...
  7. Boutros R, Lobjois V, Ducommun B. CDC25B involvement in the centrosome duplication cycle and in microtubule nucleation. Cancer Res. 2007;67:11557-64 pubmed
    ..by the CDC25 family of phosphatases in a strict spatiotemporal manner, and we have recently reported that CDC25B localizes to the centrosomes from early S phase...
  8. Nagata A, Igarashi M, Jinno S, Suto K, Okayama H. An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells. New Biol. 1991;3:959-68 pubmed
    ..Thus, at least two homologs of the cdc25 gene exist and are both expressed in human cells. The implications of CDC25Hu2 overexpression in some cancer cells are discussed. ..
  9. Galaktionov K, Beach D. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell. 1991;67:1181-94 pubmed
    Two previously unidentified human cdc25 genes have been isolated, cdc25A and cdc25B. Both genes rescue a cdc25ts mutant of fission yeast. Microinjection of anti-cdc25A antibodies into HeLa cells causes their arrest in mitosis...

More Information

Publications136 found, 100 shown here

  1. Galaktionov K, Lee A, Eckstein J, Draetta G, Meckler J, Loda M, et al. CDC25 phosphatases as potential human oncogenes. Science. 1995;269:1575-7 pubmed
    ..In human cells, CDC25 proteins are encoded by a multigene family, consisting of CDC25A, CDC25B, and CDC25C...
  2. Sanchez Y, Wong C, Thoma R, Richman R, Wu Z, Piwnica Worms H, et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 1997;277:1497-501 pubmed
    ..In vitro Chk1 bound to and phosphorylated the dual-specificity protein phosphatases Cdc25A, Cdc25B, and Cdc25C, which control cell cycle transitions by dephosphorylating cyclin-dependent kinases...
  3. Davezac N, Baldin V, Gabrielli B, Forrest A, Theis Febvre N, Yashida M, et al. Regulation of CDC25B phosphatases subcellular localization. Oncogene. 2000;19:2179-85 pubmed
    The CDC25B dual specificity phosphatase is involved in the control of the G2/M transition of the cell cycle. Subcellular localization might represent an important aspect of the regulation of its activity...
  4. Ngan E, Hashimoto Y, Ma Z, Tsai M, Tsai S. Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer. Oncogene. 2003;22:734-9 pubmed
    b>Cdc25B is a dual-specific phosphatase that mediates cell cycle progression by activating the cyclin-dependent kinases. It has been shown to possess oncogenic potential...
  5. Bulavin D, Higashimoto Y, Demidenko Z, Meek S, Graves P, Phillips C, et al. Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol. 2003;5:545-51 pubmed
    ..A similar regulatory mechanism may also apply to another mitotic phosphatase, Cdc25B, as well as mitotic phosphatases of other species, including Xenopus laevis...
  6. Dutertre S, Cazales M, Quaranta M, Froment C, Trabut V, Dozier C, et al. Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J Cell Sci. 2004;117:2523-31 pubmed
    ..In this report, we demonstrate that the CDC25B phosphatase, an activator of cyclin dependent kinases at mitosis, is phosphorylated both in vitro and in vivo by ..
  7. Lindqvist A, Källström H, Karlsson Rosenthal C. Characterisation of Cdc25B localisation and nuclear export during the cell cycle and in response to stress. J Cell Sci. 2004;117:4979-90 pubmed
    Cdc25 phosphatases are essential regulators of the cell cycle. In mammalian cells, the Cdc25B isoform activates cyclin A- and cyclin B1-containing complexes and is necessary for entry into mitosis...
  8. Kanemori Y, Uto K, Sagata N. Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases. Proc Natl Acad Sci U S A. 2005;102:6279-84 pubmed
    ..The DDG motif also exists in human Cdc25B phosphatase (another key cell-cycle regulator), binds beta-TrCP strongly, and is essential for the ubiquitination ..
  9. Boutros R, Ducommun B. Asymmetric localization of the CDC25B phosphatase to the mother centrosome during interphase. Cell Cycle. 2008;7:401-6 pubmed
    The Cyclin-Dependent Kinase (CDK)-activating phosphatase CDC25B, localises to the centrosomes where its activity is both positively and negatively regulated by several kinases including Aurora A and CHK1...
  10. Aressy B, Bugler B, Valette A, Biard D, Ducommun B. Moderate variations in CDC25B protein levels modulate the response to DNA damaging agents. Cell Cycle. 2008;7:2234-40 pubmed
    b>CDC25B, one of the three members of the CDC25 dual-specificity phosphatase family, plays a critical role in the control of the cell cycle and in the checkpoint response to DNA damage...
  11. Boutros R, Lorenzo C, Mondesert O, Jauneau A, Oakes V, Dozier C, et al. CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity. Biol Cell. 2011;103:55-68 pubmed publisher
    ..We have recently identified a pool of CDC25B at the centrosome of interphase cells that plays a role in regulating centrosome numbers...
  12. Nilsson I, Hoffmann I. Cell cycle regulation by the Cdc25 phosphatase family. Prog Cell Cycle Res. 2000;4:107-14 pubmed
    ..eukaryotic cells can be achieved through dephosphorylation by members of the Cdc25 phosphatase family, Cdc25A, Cdc25B and Cdc25C. Cdc25A plays an important role at the G1/S-phase transition...
  13. Krämer A, Mailand N, Lukas C, Syljuåsen R, Wilkinson C, Nigg E, et al. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol. 2004;6:884-91 pubmed
    ..Activation of centrosomal Cdk1 in late prophase seemed to be mediated by cytoplasmic Cdc25B, whose activity is controlled by centrosome-associated Chk1...
  14. Schmitt E, Boutros R, Froment C, Monsarrat B, Ducommun B, Dozier C. CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage. J Cell Sci. 2006;119:4269-75 pubmed
    b>CDC25B is one of the three human phosphatases that activate the CDK-cyclin complexes, thereby triggering cell-cycle progression and division...
  15. Kieffer I, Lorenzo C, Dozier C, Schmitt E, Ducommun B. Differential mitotic degradation of the CDC25B phosphatase variants. Oncogene. 2007;26:7847-58 pubmed
    CDC25 phosphatases control cell-cycle progression by dephosphorylating and activating cyclin-dependent kinases. CDC25B, one of the three members of this family in human cells, is thought to regulate initial mitotic events...
  16. Dalvai M, Mondesert O, Bourdon J, Ducommun B, Dozier C. Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors. Oncogene. 2011;30:2282-8 pubmed publisher
    b>Cdc25B phosphatases function as key players in G2/M cell cycle progression by activating the CDK1-cyclinB1 complexes. They also have an essential role in recovery from the G2/M checkpoint activated in response to DNA damage...
  17. Ollila H, Soronen P, Silander K, Palo O, Kieseppä T, Kaunisto M, et al. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. Mol Psychiatry. 2009;14:351-3 pubmed publisher
  18. Xu N, Zhang X, Wang X, Ge H, Wang X, Garfield D, et al. FoxM1 mediated resistance to gefitinib in non-small-cell lung cancer cells. Acta Pharmacol Sin. 2012;33:675-81 pubmed publisher
    ..expression of several downstream targets of FoxM1, including survivin, cyclin B1, SKP2, PLK1, Aurora B kinase and CDC25B, were significantly upregulated...
  19. Jeon Y, Ko K, Lee J, Park K, Jang J, Kim I. Identification of a redox-modulatory interaction between selenoprotein W and 14-3-3 protein. Biochim Biophys Acta. 2016;1863:10-8 pubmed publisher
    ..We have previously reported that the binding of 14-3-3 protein to its target proteins, including CDC25B, Rictor and TAZ, is inhibited by the interaction of 14-3-3 protein with SelW...
  20. Lemaire M, Froment C, Boutros R, Mondesert O, Nebreda A, Monsarrat B, et al. CDC25B phosphorylation by p38 and MK-2. Cell Cycle. 2006;5:1649-53 pubmed
    b>CDC25B is one of the three human phosphatases that are involved in the control of the activation of cyclin-dependent kinases...
  21. Bugler B, Schmitt E, Aressy B, Ducommun B. Unscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage. Mol Cancer. 2010;9:29 pubmed publisher
    b>CDC25B phosphatase is a cell cycle regulator that plays a critical role in checkpoint control...
  22. Agius E, Bel Vialar S, Bonnet F, Pituello F. Cell cycle and cell fate in the developing nervous system: the role of CDC25B phosphatase. Cell Tissue Res. 2015;359:201-13 pubmed publisher
    ..Here, we summarize recent data describing how cell cycle dynamics affect the switch between proliferation and differentiation, with an emphasis on the roles played by the cell cycle regulators, the CDC25 phosphatases. ..
  23. Perwitasari O, Torrecilhas A, Yan X, Johnson S, White C, Tompkins S, et al. Targeting cell division cycle 25 homolog B to regulate influenza virus replication. J Virol. 2013;87:13775-84 pubmed publisher
    ..One pro-influenza virus host gene identified was dual-specificity phosphatase cell division cycle 25 B (CDC25B)...
  24. Capasso A, Cerchia C, Di Giovanni C, Granato G, Albano F, Romano S, et al. Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells. Oncotarget. 2015;6:40202-22 pubmed publisher
  25. Iyirhiaro G, Im D, Boonying W, Callaghan S, During M, Slack R, et al. Cdc25A Is a Critical Mediator of Ischemic Neuronal Death In Vitro and In Vivo. J Neurosci. 2017;37:6729-6740 pubmed publisher
    ..In contrast, neurons singly or doubly deficient for Cdc25B/C were not significantly protective...
  26. Lafarga V, Sung H, Haneke K, Roessig L, Pauleau A, Bruer M, et al. TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress. EMBO Rep. 2019;20: pubmed publisher
    ..instability in response to replication stress, in a manner that can be alleviated by the concomitant depletion of Cdc25B or inhibition of CDK1...
  27. Begum N, Shen W, Manganiello V. Role of PDE3A in regulation of cell cycle progression in mouse vascular smooth muscle cells and oocytes: implications in cardiovascular diseases and infertility. Curr Opin Pharmacol. 2011;11:725-9 pubmed publisher
    ..cell cycle arrest at Gâ‚‚/M phase because increased cAMP/PKA signaling in KO oocytes most likely inhibits Cdc25B-catalyzed dephosphorylation/activation of Cdc2 (maturation promoting factor (MPF)), a key regulator of Gâ‚‚/M ..
  28. Premkumar K, Chaube S. Nitric oxide signals postovulatory aging-induced abortive spontaneous egg activation in rats. Redox Rep. 2015;20:184-92 pubmed publisher
    ..expression, NO, cytosolic free Ca(2+), 3',5' cyclic guanosine monophosphate (cGMP), cell division cycle 25B (Cdc25B) and Wee1 levels, specific phosphorylation (pThr-14/Tyr-15) as well as total cyclin-dependent kinases-1 (Cdk1) (..
  29. Niu M, Cai W, Liu H, Chong Y, Hu W, Gao S, et al. Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression. J Pharmacol Sci. 2015;128:131-6 pubmed publisher
    ..we also determined that the expressions of FOXM1 and its downstream target effectors, including cyclin D1 and Cdc25B, were down-regulated in the treated group, while the expressions of p21 and p27 were increased; the latter ..
  30. Pan C, Zhu D, Wang Y, Li L, Li D, Liu F, et al. Human Cytomegalovirus miR-UL148D Facilitates Latent Viral Infection by Targeting Host Cell Immediate Early Response Gene 5. PLoS Pathog. 2016;12:e1006007 pubmed publisher
    ..cells and promotes HCMV latency by modulating the immediate early response gene 5 (IER5)-cell division cycle 25B (CDC25B) axis in host cells...
  31. Kumar M, Faraji M, Sarwalia P, Kumar S, Gohain M, De S, et al. Propensity in low-grade oocytes for delayed germinal vesicle breakdown compromises the developmental ability of sub-optimal grade Bubalus bubalis oocytes. Zygote. 2018;26:359-365 pubmed publisher
    ..The expression of AKT and CDC25B genes for BCB+ oocytes was maximum at 8 h of IVM, and CCNB (cyclin B) peaked at around 10 h, which suggested that ..
  32. Wu J, Zhang H, Duan Y, Dong W, Cheng X, Wang S, et al. Design novel inhibitors for treating cancer by targeting Cdc25B catalytic domain with de novo design. Comb Chem High Throughput Screen. 2014;17:837-47 pubmed
    ..To develop novel Cdc25B inhibitors, the ZINC database was screened for finding optimal fragments with de novo design approaches...
  33. Kohama Y, Saito M, Yada M, Sakurai H. Regulation of the stability and activity of CDC25A and CDC25B by protein phosphatase PP2A and 14-3-3 binding. Cell Signal. 2019;54:10-16 pubmed publisher
    Cyclin-dependent kinase (CDK)-activating phosphatases, CDC25A and CDC25B, are labile proteins, and their levels vary in a cell cycle-dependent manner...
  34. Li H, Ma Y, Li Y, Chen X, Dong W, Wang R. The design of novel inhibitors for treating cancer by targeting CDC25B through disruption of CDC25B-CDK2/Cyclin A interaction using computational approaches. Oncotarget. 2017;8:33225-33240 pubmed publisher
    ..focused on identifying potential compounds in theory which are able to disrupt transient interactions between CDC25B and its CDK2/Cyclin A substrate...
  35. Rostom S, Badr M, Abd El Razik H, Ashour H. Structure-based development of novel triazoles and related thiazolotriazoles as anticancer agents and Cdc25A/B phosphatase inhibitors. Synthesis, in vitro biological evaluation, molecular docking and in silico ADME-T studies. Eur J Med Chem. 2017;139:263-279 pubmed publisher
    ..activity (a possible antitumor target), where 18 and 22 displayed a distinctive inhibitory affinity towards the Cdc25B isozyme (6.7 and 8.4 ?M, respectively)...
  36. Brenner A, Reikvam H, Lavecchia A, Bruserud Ø. Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms. Molecules. 2014;19:18414-47 pubmed publisher
    The cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C. These three molecules are important regulators of several steps in the cell cycle, including the activation of various cyclin-dependent kinases (CDKs)...
  37. George Rosenker K, Paquette W, Johnston P, Sharlow E, Vogt A, Bakan A, et al. Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B. Bioorg Med Chem. 2015;23:2810-8 pubmed publisher
    The cell division cycle 25B dual specificity phosphatase (Cdc25B) regulates the normal progression of the mammalian cell cycle by dephosphorylating and activating cyclin-dependent kinase (Cdk) complexes, particularly in response to DNA ..
  38. Molnár J, Frank Ã, Minorics R, Kádár Z, Ocsovszki I, Schönecker B, et al. A click approach to novel D-ring-substituted 16α-triazolylestrone derivatives and characterization of their antiproliferative properties. PLoS ONE. 2015;10:e0118104 pubmed publisher
    ..The levels of cell cycle regulators (CDK1, cyclin B1/B2 and cdc25B) were decreased and the ratio Bax/Bcl-2 was increased 24 h after the treatment of HeLa cells (determined at an ..
  39. Leal M, Ribeiro H, Rey J, Pinto G, Smith M, Moreira Nunes C, et al. YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells: new insights about YWHAE role in the tumor development and metastasis process. Oncotarget. 2016;7:85393-85410 pubmed publisher
    ..YWHAE may act as a negative regulator of the cyclin CDC25B, which is a transcriptional target of MYC oncogene...
  40. Castro Sánchez P, Ramirez Munoz R, Lamana A, Ortiz A, Gonzalez Alvaro I, Roda Navarro P. mRNA profiling identifies low levels of phosphatases dual‐specific phosphatase‐7 (DUSP7) and cell division cycle‐25B (CDC25B) in patients with early arthritis. Clin Exp Immunol. 2017;189:113-119 pubmed publisher
    ..protein kinase (MAPK) phosphatase dual-specific phosphatase-7 (DUSP7) and the cell division cycle-25B (CDC25B) in T cells of patients...
  41. Lemaire M, Ducommun B, Nebreda A. UV-induced downregulation of the CDC25B protein in human cells. FEBS Lett. 2010;584:1199-204 pubmed publisher
    The CDC25B phosphatase regulates the activation of CDK1-Cyclin B at the onset of mitosis, being a key target of the checkpoint pathways activated by cellular stress and DNA damage...
  42. Lyons J, Bastian B, McCormick F. MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells. Proc Natl Acad Sci U S A. 2013;110:13845-50 pubmed publisher
    ..This delay is caused by phosphorylation and inhibition of cdc25B, a cyclin dependent kinase 1-activating phosphatase, and is rescued by expression of a cdc25B mutant that cannot ..
  43. Song G, Zhao Y. MicroRNA-211, a direct negative regulator of CDC25B expression, inhibits triple-negative breast cancer cells' growth and migration. Tumour Biol. 2015;36:5001-9 pubmed publisher
    ..The abnormal expression of CDC25B phosphatases detected in a number of tumors implies that their dysregulation is involved in malignant ..
  44. Li Y, Huang H, Chen L, Xu L, Li E, Zhang J. Predictive biomarkers for response of esophageal cancer to chemo(radio)therapy: A systematic review and meta-analysis. Surg Oncol. 2017;26:460-472 pubmed publisher
    ..001) and 1.69 (n = 144, 95% CI 1.10-2.61, P = 0.02), respectively. High expression of (or IHC-positive) CDC25B and p16 was individually related to prediction of response. The RR was 0.62 (n = 159, 95% CI 0.43-0.89, P = 0...
  45. Lund G, Cierpicki T. Solution NMR studies reveal no global flexibility in the catalytic domain of CDC25B. Proteins. 2014;82:2889-95 pubmed publisher
    The CDC25B phosphatase is a critical regulator of the cell cycle and has been validated as an important therapeutic target in cancer...
  46. Qiu G, Wang S, Li D, Li J. [Impact of miR-148a on the proliferation of gastric carcinoma MKN45 cells and its mechanism]. Zhonghua Wei Chang Wai Ke Za Zhi. 2014;17:1036-9 pubmed
    ..05). From the third day after transfection, the growth of MKN45 cells was significantly inhibited(P<0.01). Gene CDC25B might be the target gene of miR-148a according to the results of targetscan...
  47. Liu X, Cai W, Niu M, Chong Y, Liu H, Hu W, et al. Plumbagin induces growth inhibition of human glioma cells by downregulating the expression and activity of FOXM1. J Neurooncol. 2015;121:469-77 pubmed publisher
    ..ability of FOXM1, resulting in down-regulating the expression of FOXM1 downstream target genes, such as cyclin D1, Cdc25B, survivin, and increasing the expression of p21(CIP1) and p27(KIP1)...
  48. Cui C, Zang T, Cao Y, Qin X, Zhang X. CDC25B is involved in the centrosomal microtubule nucleation in two-cell stage mouse embryos. Dev Growth Differ. 2016;58:714-726 pubmed publisher
    b>CDC25B has been demonstrated to activate the complex of CDK1/Cyclin B and trigger mitosis...
  49. Brisson M, Foster C, Wipf P, Joo B, Tomko R, Nguyen T, et al. Independent mechanistic inhibition of cdc25 phosphatases by a natural product caulibugulone. Mol Pharmacol. 2007;71:184-92 pubmed
    ..The in vitro inhibition of Cdc25B by caulibugulone A was irreversible and attenuated by reducing agents or catalase, consistent with direct ..
  50. Teng Y, Chung C, Lin Y, Pan H, Liao R, Kuo P. Expression of various CDC25B isoforms in human spermatozoa. Fertil Steril. 2007;88:379-82 pubmed
    To explore the role of CDC25B protein in postmeiotic germ cells. In vitro experiment. University-based reproductive genetics laboratory. Fertile and infertile volunteers...
  51. Boldrini L, Gisfredi S, Ursino S, Lucchi M, Mussi A, Fontanini G. CDC25B: relationship with angiogenesis and prognosis in non-small cell lung carcinoma. Hum Pathol. 2007;38:1563-8 pubmed
    ..Increased expression of CDC25B has been reported in tumors of different tissue origins, including non-small cell lung carcinoma (NSCLC)...
  52. Wu C, Liu S, Lee Y, Wang R, Sun S, Yin F, et al. RSK promotes G2/M transition through activating phosphorylation of Cdc25A and Cdc25B. Oncogene. 2014;33:2385-94 pubmed publisher
    ..In human HEK293 and PC-3mm2 cell lines, RSK preferentially phosphorylates Cdc25A and Cdc25B in mitotic cells...
  53. Bryzgalov L, Korbolina E, Brusentsov I, Leberfarb E, Bondar N, Merkulova T. Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia. BMC Neurosci. 2018;19:22 pubmed publisher
    ..expression between patient and control groups depending on brain region: NRAS-in schizophrenia cohort, CDC25B, DDX21 and NUCKS1-in bipolar disorder cohort...
  54. Ito Y, Yoshida H, Matsuzuka F, Matsuura N, Nakamura Y, Nakamine H, et al. Cdc25A and cdc25B expression in malignant lymphoma of the thyroid: correlation with histological subtypes and cell proliferation. Int J Mol Med. 2004;13:431-5 pubmed
    b>Cdc25B and cdc25A phosphatases are representative stimulators of cell cycle progression, and recent studies have also indicated their oncogenic roles...
  55. Yang P, Liu D, Liang T, Li J, Zhang H, Liu A, et al. Bioactive constituents from the green alga Caulerpa racemosa. Bioorg Med Chem. 2015;23:38-45 pubmed publisher
    ..inhibitory activities of the isolated compounds were evaluated in vitro against PTP1B and related PTPs (TCPTP, CDC25B, LAR, SHP-1, and SHP-2)...
  56. Tao L, Ma J, Han L, Xu H, Zeng Y, Yehui L, et al. Early postmortem interval estimation based on Cdc25b mRNA in rat cardiac tissue. Leg Med (Tokyo). 2018;35:18-24 pubmed publisher
    ..Among all of the candidate markers, △Cq (cell division cycle 25 homolog B(Cdc25b)) had the best correlation coefficient with early postmortem interval and was used to build a new model using the ..
  57. Wei P, Liu L, Liu T, Chen C, Luo D, Shi B. Three new pigment protein tyrosine phosphatases inhibitors from the insect parasite fungus Cordyceps gracilioides: terreusinone A, pinophilin C and cryptosporioptide A. Molecules. 2015;20:5825-34 pubmed publisher
    ..In an in vitro activity assay, 1, 2 and 3 exhibited high inhibitory activity against PTP1B, SHP2, CDC25B, LAR and SHP1. Terreusinone A (1) inhibited PTP1B, SHP2, CDC25B, LAR and SHP1 enzyme with IC50 values 12...
  58. Broustas C, Xu Y, Harken A, Garty G, Amundson S. Comparison of gene expression response to neutron and x-ray irradiation using mouse blood. BMC Genomics. 2017;18:2 pubmed publisher
    ..However, five cell cycle genes, Fzr1, Ube2c, Ccna2, Nusap1, and Cdc25b, were both downregulated at day 1 and upregulated at day 7...
  59. Zhang J, Lu F, Lu T, Dong W, Li P, Liu N, et al. Inactivation of FoxM1 transcription factor contributes to curcumin-induced inhibition of survival, angiogenesis, and chemosensitivity in acute myeloid leukemia cells. J Mol Med (Berl). 2014;92:1319-30 pubmed publisher
    ..and its downstream genes, such as cyclin B1, cyclin-dependent kinase (CDK) 2, S-phase kinase-associated protein 2, Cdc25B, survivin, Bcl-2, matrix metalloproteinase (MMP)-2, MMP-9, and vascular endothelial growth factor (VEGF), as well ..
  60. Uchida S, Yoshioka K, Kizu R, Nakagama H, Matsunaga T, Ishizaka Y, et al. Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation. Cancer Res. 2009;69:6438-44 pubmed publisher
    ..However, the roles of Cdc25B and Cdc25C in cell stress checkpoints remain inconclusive...
  61. Gao D, Inuzuka H, Tan M, Fukushima H, Locasale J, Liu P, et al. mTOR drives its own activation via SCF(?TrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell. 2011;44:290-303 pubmed publisher
  62. Zhang Z, Rui W, Wang Z, Liu D, Du L. Anti-proliferation and anti-metastasis effect of barbaloin in non-small cell lung cancer via inactivating p38MAPK/Cdc25B/Hsp27 pathway. Oncol Rep. 2017;38:1172-1180 pubmed publisher
    ..The results revealed that barbaloin inactivated the p38MAPK/Cdc25B/Hsp27 pathway by inhibiting p38 nucleus translocation, while no significant influence was observed among other ..
  63. Weber H, Gidekel M, Werbajh S, Salvatierra E, Rotondaro C, Sganga L, et al. A Novel CDC25B Promoter-Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models. Clin Cancer Res. 2015;21:1665-74 pubmed publisher
    We decided to construct a novel oncolytic adenovirus whose replication was driven by the CDC25B promoter for its use in preclinical models of pancreatic cancer. We placed the essential E1A gene under control of the CDC25B promoter...
  64. Chan On W, Huyen N, Songtawee N, Suwanjang W, Prachayasittikul S, Prachayasittikul V. Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells. Drug Des Devel Ther. 2015;9:2033-47 pubmed publisher
    ..FoxM1 was markedly decreased concomitant with downregulation of various FoxM1's downstream targets including cdc25b, CENP-B, and survivin...
  65. Rattani A, Ballesteros Mejia R, Roberts K, Roig M, Godwin J, Hopkins M, et al. APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity. Curr Biol. 2017;27:1462-1476.e5 pubmed publisher
    ..We show here that, by promoting proteolysis of cyclins and Cdc25B at the germinal vesicle (GV) stage, APC/C associated with the Cdh1 protein (APC/CCdh1) delays the ..
  66. Cheng A, Gerry S, Kaldis P, Solomon M. Biochemical characterization of Cdk2-Speedy/Ringo A2. BMC Biochem. 2005;6:19 pubmed
  67. Jemaà M, Mischitelli M, Fezai M, Almasry M, Faggio C, Lang F. Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC-95397. Cell Physiol Biochem. 2016;40:597-607 pubmed
    The CDC25B inhibitor NSC-95397 triggers apoptosis of tumor cells and is thus considered for the treatment of malignancy. The substance is effective in part by modification of gene expression...
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