CD90

Summary

Gene Symbol: CD90
Description: Thy-1 cell surface antigen
Alias: CD90, CDw90, Thy-1 T-cell antigen, thy-1 antigen, thy-1 membrane glycoprotein
Species: human

Top Publications

  1. ncbi Augmentation of the resistance against Listeria monocytogenes by oral administration of a hot water extract of Chlorella vulgaris in mice
    T Hasegawa
    Laboratory of Germfree Life, Nagoya University School of Medicine, Japan
    Immunopharmacol Immunotoxicol 16:191-202. 1994
  2. ncbi Exogenous interleukin-3 enhances IL-4 production by splenic CD4+ cells during the early stages of a Trichinella spiralis infection
    M Korenaga
    Department of Parasitology, Kochi Medical School, Kochi, Japan
    Int Arch Allergy Immunol 117:131-7. 1998
  3. pmc Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes
    Laura Koumas
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 163:1291-300. 2003
  4. pmc Does the human skeletal muscle harbor the murine equivalents of cardiac precursor cells?
    Susanne Proksch
    INSERM U 633, Laboratory of Biosurgical Research, Hopital Broussais, Paris, France
    Mol Ther 17:733-41. 2009
  5. ncbi An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer
    Xianglan Zhang
    Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120 752, Korea
    Int J Oncol 36:405-14. 2010
  6. pmc Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes
    Laura E Pascal
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    BMC Cancer 9:317. 2009
  7. ncbi The Thy-1/Thy-1 ligand interaction is involved in binding of melanoma cells to activated Thy-1- positive microvascular endothelial cells
    A Saalbach
    Department of Dermatology, University of Leipzig, 04103 Leipzig, Germany
    Microvasc Res 64:86-93. 2002
  8. pmc Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts
    Hongjuan Zhao
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    Prostate 69:991-1000. 2009
  9. pmc The human Thy-1 gene: structure and chromosomal location
    T Seki
    Proc Natl Acad Sci U S A 82:6657-61. 1985
  10. ncbi CD34(+) cell subsets and long-term culture colony-forming cells evaluated on both autologous and normal bone marrow stroma predict long-term hematopoietic engraftment in patients undergoing autologous peripheral blood stem cell transplantation
    F Lanza
    Section of Hematology and BMT Unit, Department of Biomedical Sciences and Advanced Therapies, University Hospital, Ferrara, Italy
    Exp Hematol 29:1484-93. 2001

Detail Information

Publications170 found, 100 shown here

  1. ncbi Augmentation of the resistance against Listeria monocytogenes by oral administration of a hot water extract of Chlorella vulgaris in mice
    T Hasegawa
    Laboratory of Germfree Life, Nagoya University School of Medicine, Japan
    Immunopharmacol Immunotoxicol 16:191-202. 1994
    ....
  2. ncbi Exogenous interleukin-3 enhances IL-4 production by splenic CD4+ cells during the early stages of a Trichinella spiralis infection
    M Korenaga
    Department of Parasitology, Kochi Medical School, Kochi, Japan
    Int Arch Allergy Immunol 117:131-7. 1998
    ..IL-4 production was suppressed in rIL-3-treated mice injected with anti-CD4 mAb. These results suggest that IL-3 might play a role as Th2 amplifier in immune response to parasite infection...
  3. pmc Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes
    Laura Koumas
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 163:1291-300. 2003
    ....
  4. pmc Does the human skeletal muscle harbor the murine equivalents of cardiac precursor cells?
    Susanne Proksch
    INSERM U 633, Laboratory of Biosurgical Research, Hopital Broussais, Paris, France
    Mol Ther 17:733-41. 2009
    ..Skeletal muscle biopsies obtained from 39 patients were sorted by flow cytometry which generated three populations (CD90+/CD34(-), CD34+/CD90(-), CD90(-)/CD34(-)) expressing similar levels of cardiac (Nkx2...
  5. ncbi An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer
    Xianglan Zhang
    Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120 752, Korea
    Int J Oncol 36:405-14. 2010
    ..Mechanism-wise GPX3 down-regulation in gastric cancer is due to promoter hypermethylation. Collectively, these results show a correct identification of 8 genes as gastric cancer biomarkers...
  6. pmc Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes
    Laura E Pascal
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    BMC Cancer 9:317. 2009
    ..The tumor-associated stroma is marked by increased expression of CD90/THY1...
  7. ncbi The Thy-1/Thy-1 ligand interaction is involved in binding of melanoma cells to activated Thy-1- positive microvascular endothelial cells
    A Saalbach
    Department of Dermatology, University of Leipzig, 04103 Leipzig, Germany
    Microvasc Res 64:86-93. 2002
    ....
  8. pmc Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts
    Hongjuan Zhao
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    Prostate 69:991-1000. 2009
    Cancer-associated stroma contributes to the malignant behavior of adenocarcinomas of the prostate and other organs. CD90 is a marker of mesenchymal stem cells (MSCs) and its expression is higher in prostate cancer stroma compared to ..
  9. pmc The human Thy-1 gene: structure and chromosomal location
    T Seki
    Proc Natl Acad Sci U S A 82:6657-61. 1985
    ..The structural gene for human Thy-1 was localized to the long arm of chromosome 11 by nucleic acid hybridization to genomic DNA isolated from somatic cell hybrids...
  10. ncbi CD34(+) cell subsets and long-term culture colony-forming cells evaluated on both autologous and normal bone marrow stroma predict long-term hematopoietic engraftment in patients undergoing autologous peripheral blood stem cell transplantation
    F Lanza
    Section of Hematology and BMT Unit, Department of Biomedical Sciences and Advanced Therapies, University Hospital, Ferrara, Italy
    Exp Hematol 29:1484-93. 2001
    ....
  11. ncbi Enhancement of immunoglobulin A production in Peyer's patches by oral administration of a traditional Chinese medicine, xiao-chai-hu-tang (Shosaiko-to)
    Y Tauchi
    Traditional Chinese Medicine Research Laboratories, Kanebo, Ltd, Osaka, Japan
    Immunopharmacol Immunotoxicol 15:251-72. 1993
    ..2-TcR alpha beta+T cells in the mesenteric lymph nodes were slight increased. These results showed that orally administered Shosaiko-to acts as a polyclonal B-cell activator which induces IgA production in the mucosal immune system...
  12. ncbi A system for inducible gene expression in retinal ganglion cells
    John B Kerrison
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 46:2932-9. 2005
    ..To develop a system for inducible gene expression in retinal ganglion cells, Thy1 and ckit promoters were used to direct expression of a second-generation reverse tetracycline transactivator (rtTA2S-M2)...
  13. ncbi T-cell-activating monoclonal antibodies, reacting with both leukocytes and erythrocytes, recognize the guinea pig Thy-1 differentiation antigen: characterization and cloning of guinea pig CD90
    H Schafer
    Department of Immunology, Robert Koch Institute, Berlin, Germany
    Cell Immunol 197:116-28. 1999
    ..by immunoadsorption and microsequencing revealed that this T-cell-activating protein is the homologue of Thy-1 or CD90. In contrast to the Thy-1 antigen of most other species, guinea pig Thy-1 has a much higher molecular weight, which ..
  14. doi A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs
    Diana Campioni
    Hematology Section, University, St Anna Hospital, Corso Giovecca n 203, Ferrara, Italy
    Cytometry B Clin Cytom 76:225-30. 2009
    ..The CD90+ hMSC reduced lymphoproliferative response in phytohemagglutinin (PHA) activated peripheral blood mononuclear cells ..
  15. ncbi Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 12:2300-9. 2001
    ..It was concluded that the beneficial effects of retinoids on glomerular damage are presumably due to a marked reduction in renal TGF-beta 1 and TGF receptor II expression...
  16. ncbi Expression of CX3CL1/fractalkine by mesangial cells in vitro and in acute anti-Thy1 glomerulonephritis in rats
    Yung Ming Chen
    Department of Internal Medicine, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei 10016, Taiwan
    Nephrol Dial Transplant 18:2505-14. 2003
    ..This study investigated the potential of MCs to synthesize CX3CL1/fractalkine, a CX3C chemokine, both in vitro and in acute anti-Thy1 glomerulonephritis in rats...
  17. ncbi Experimental African trypanosomiasis: a subset of pathogenic, IFN-gamma-producing, MHC class II-restricted CD4+ T cells mediates early mortality in highly susceptible mice
    Meiqing Shi
    Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
    J Immunol 176:1724-32. 2006
    ..We speculate that IL-10-producing CD4+ T cells might counteract this effect...
  18. doi Bone marrow cells immunomagnetically selected for CD271+ antigen promote in vitro the repair of articular cartilage defects
    Tamara Hermida-Gómez
    Biomedical Research Center, INIBIC Hospital Universitario A Coruña, University of A Coruna, A Coruna, Spain
    Tissue Eng Part A 17:1169-79. 2011
    ....
  19. ncbi NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritis
    Harm Peters
    Division of Nephrology and Institute of Pathology, Charite, Campus Mitte, Humboldt University, Berlin, Germany
    Kidney Int 64:509-18. 2003
    ..NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritis...
  20. ncbi Antibody-induced albuminuria and accelerated focal glomerulosclerosis in the Thy-1.1 transgenic mouse
    Karel J M Assmann
    Department of Pathology, Division of Nephrology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Kidney Int 62:116-26. 2002
    ..1 transgenic mouse. This mouse expresses a hybrid human-mouse Thy-1.1 antigen on the podocytes, and slowly but spontaneously develops albuminuria and focal glomerulosclerosis...
  21. doi Differentiation of synovial CD-105(+) human mesenchymal stem cells into chondrocyte-like cells through spheroid formation
    M C Arufe
    Osteoarticular and Aging Research Laboratory, Cell Therapy Unit Biomedical Research Center, INIBIC Hospital Universitario A Coruña, Coruna, Spain
    J Cell Biochem 108:145-55. 2009
    ..studies have used the total population of MSCs, including cells with several MSC markers, such as CD44, CD90, CD105, or CD73. However the chondrogenic capacity of an individual population of MSCs has not been examined...
  22. pmc Progressive damage along the optic nerve following induction of crush injury or rodent anterior ischemic optic neuropathy in transgenic mice
    O Dratviman-Storobinsky
    The Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Tel Aviv University, Petah Tiqwa, Israel
    Mol Vis 14:2171-9. 2008
    ..To characterize the histological changes that occur in response to induction of ischemic or mechanical optic nerve damage in transgenic mice...
  23. ncbi Changes in the populations of null, NK1.1+, and Thy1lo lymphocytes in the bone marrow of tumor-bearing mice: effect of indomethacin treatment
    M D Rahal
    Department of Anatomy, McGill University, Montreal, Quebec, Canada
    Cell Immunol 139:218-28. 1992
    ..The results suggest that the production of null lymphocytes in mouse bone marrow is responsive to tumor development, possibly providing cells to be involved in tumor-host interactions...
  24. ncbi Neonatal estrogen treatment and its consequences for thymus development, serum level of autoantibodies to cardiolipin, and the delayed-type hypersensitivity response
    J G Forsberg
    Tornblad Institute, University of Lund, Sweden
    J Toxicol Environ Health A 60:185-213. 2000
    ..2 marker or percentages of CD4+/CD8+ DP or SP subsets in thymus and spleen, qualitative and quantitative differences occur in immune parameters (autoantibodies to cardiolipin) and a T-cell-dependent immune response (DTH)...
  25. ncbi Induction of tumoricidal macrophages from bone marrow cells of normal mice or mice bearing a colony-stimulating-factor-producing tumor
    S Hosoe
    Third Department of Internal Medicine, Osaka University Medical School, Japan
    Cancer Immunol Immunother 28:116-22. 1989
    ..These results strongly suggest that M-CSF plays an important role not only in the maturation of macrophage progenitors but also in the induction and the accumulation of activated macrophages...
  26. ncbi [Expression of THY1 gene in epithelial ovarian cancer]
    Li qin Zeng
    Department of Gynecology, Guangdong Women s and Children s Hospital and Health Institute, Guangzhou 510010, China
    Zhonghua Zhong Liu Za Zhi 31:118-20. 2009
    ..To detect the expession of THY1 in ovarian serous cystadenocarcinoma tissues...
  27. pmc Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium
    Giorgia Jurisic
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Exp Cell Res 316:2982-92. 2010
    ..mouse intestinal lymphatic endothelial cells versus blood vascular endothelial cells, thymus cell antigen 1 (Thy1, CD90) was expressed at much higher levels in lymphatic endothelial cells than in blood vascular endothelial cells...
  28. doi Cellular volume and marker expression in human peripheral blood apheresis stem cells
    Siddharth Sharma
    Department of Pathology, University of Miami Miller School of Medicine, Sylvester Cancer Center, Miami, Florida 33101, USA
    Cytometry A 73:160-7. 2008
    ..solution), or processed by Ficoll Hypaque sedimentation method were stained with CD45-FITC and PE-labeled CD34, CD90, CD117, and CD133 antibodies and analyzed for electronic volume and two color fluorescence...
  29. ncbi Persistent infection of mice by lactate dehydrogenase-elevating virus: effects of immunosuppression on virus replication and antiviral immune responses
    C O Onyekaba
    Department of Microbiology, Medical School University of Minnesota, Minneapolis 55455
    Virus Res 14:297-315. 1989
    ..The steady-state viremia attained about 5 weeks after infection reflects a balance between LDV replication in permissive macrophages as they arise and LDV inactivation and clearance...
  30. pmc Archaeal Pyrococcus furiosus thymidylate synthase 1 is an RNA-binding protein
    Akio Kanai
    Institute for Advanced Biosciences, Keio University, Tsuruoka, 997 0017, Japan
    Biochem J 393:373-9. 2006
    ....
  31. ncbi Retinoic acid reduces glomerular injury in a rat model of glomerular damage
    J Wagner
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 11:1479-87. 2000
    ..001). It is concluded that all-trans-RA limits glomerular proliferation, glomerular lesions, and albuminuria in an established model of renal damage. The findings point to retinoids as potential novel modulators of glomerular injury...
  32. ncbi Kinetics of adaptive immunity to Haemophilus influenzae type b meningitis in transgenic mice: evidence from diverse expression of double T1/T2 transgenes and Th1/Th2-related cytokines
    Shyi Jou Chen
    The Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
    Immunol Lett 105:6-15. 2006
    ..Our results support that these transgenic mice provide an available model to dissect the complex kinetic change of adaptive immunity in bacterial infectious diseases...
  33. ncbi The characterization of the monoclonal antibody Th-10a, specific for a nuclear protein appearing in the S phase of the cell cycle in normal thymocytes and its unregulated expression in lymphoma cell lines
    M Muto
    Division of Biology and Oncology, National Institute of Radiological Science, Chiba, Japan
    Cell Prolif 28:645-57. 1995
    ..The nuclear protein(s) detected by Th-10a monoclonal antibody was mostly 95 kDa and also 83 kDa polypeptide. The results also indicated that the 95 kDa nuclear protein was phosphorylated in vivo...
  34. ncbi Expression of CD90 on keratinocyte stem/progenitor cells
    Y Nakamura
    Division of Hematopoiesis, Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Br J Dermatol 154:1062-70. 2006
    ..Here, we report the detection of CD90(+) cells in cultured normal human epidermal keratinocytes and adult skin.
  35. ncbi Signal transduction involved in protective effects of 15(R/S)-methyl- lipoxin A(4) on mesangioproliferative nephritis in rats
    Sheng Hua Wu
    Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China
    Prostaglandins Leukot Essent Fatty Acids 76:173-80. 2007
    ..1 antibodies. Protective effects of 15(R/S)-methyl-LXA(4) on nephritis induced by anti-Thy1.1 antibodies were related to PI3-K/Akt(1)/p27(kip1)/cyclin pathway, STAT(3) and NF-kappaB pathway-dependent signal transduction...
  36. ncbi Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivo
    C P Hugo
    Division of Nephrology, Universitat Erlangen Nurnberg, Erlangen, Germany
    Kidney Int 55:2236-49. 1999
    ....
  37. doi Longitudinal profile of retinal ganglion cell damage assessed with blue-light confocal scanning laser ophthalmoscopy after ischaemic reperfusion injury
    C K S Leung
    Hamilton Glaucoma Center, University of California, San Diego, La Jolla, CA 92093 0946, USA
    Br J Ophthalmol 93:964-8. 2009
    ....
  38. doi Intra-bone marrow cotransplantation of donor mesenchymal stem cells in pig-to-NOD/SCID mouse bone marrow transplantation facilitates short-term xenogeneic hematopoietic engraftment
    H Eguchi
    Center for International Relations, Osaka University Graduate School of Medicine, Osaka, Japan
    Transplant Proc 40:574-7. 2008
    ..Porcine MSC prepared by aspiration of iliac BM of miniature swine were identified as CD90+CD29+CD45-CD31- and shown to differentiate into osteoblastocytes and adipocytes...
  39. ncbi [T lymphocytes are necessary for the peripheral phase of B lymphocyte maturation]
    Novica M Milicevic
    Institute of Histology and Embryology Aleksandar D Kostic, School of Medicine, University of Belgrade, Belgrade
    Srp Arh Celok Lek 136:166-70. 2008
    ..We showed that the proportion of immature B lymphocyte subsets (CD90(high)IgM(high) and CD90(high)IgM(low)) was significantly increased, whereas that of mature B lymphocyte subsets (..
  40. ncbi Graft-vs-leukemia activity and graft-vs-host disease induced by allogeneic Th1- and Th2-type CD4+ T cells in mice
    M Zeis
    2nd Department of Internal Medicine, University of Kiel, Kiel, Germany
    Hematol J 2:136-44. 2001
    ..Therefore, separation of GVL- and GVH-reactions is a long-standing goal of experimental studies dealing with allogeneic transplantation of hematopoietic stem cells...
  41. ncbi [Influence of co-culturing vascular endothelial cells and adipose-derived stromal cells on osteogenic differentiation in vitro]
    Fuke Wang
    Department of Head and Neck Surgery, the 1st Affiliated Hospital of Kunming Medical College, Kunming Yunnan, 650032, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:399-405. 2010
    ....
  42. ncbi Polysaccharide (ANK-102) from Polianthes tuberosa cells deteriorates the resistance of mice to Listeria monocytogenes infection
    T Majima
    Department of Ontogeny and Development, Tohoku University, Sendai, Japan
    Immunopharmacol Immunotoxicol 17:59-68. 1995
    ..2 expression on the surface of the thymocytes. A new type of immunosuppressive polysaccharide ANK-102 was introduced...
  43. pmc Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis
    Christian A Seemayer
    Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Switzerland
    Am J Pathol 162:1549-57. 2003
    ....
  44. ncbi Endogenous and adoptively transferred A-NK and T-LAK cells continuously accumulate within murine metastases up to 48 h after inoculation
    M Hokland
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    In Vivo 13:199-204. 1999
    ..These data underline the longevity of LAK cells in vivo and highlight the importance of IL-2 treatment in recruiting endogenous immune cells to tumor areas...
  45. ncbi Induction of regional collateral sprouting following muscle denervation
    Jason W Koob
    Departments of Plastic and Reconstructive Surgery, Washington University, Saint Louis, Missouri, USA
    Laryngoscope 117:1735-40. 2007
    ..We hypothesize that epineurial injury is required to induce collateral sprouting toward a neighboring denervated muscle...
  46. pmc Thy1-positive bone marrow stem cells express liver-specific genes in vitro and can mature into hepatocytes in vivo
    Si Hyun Bae
    Department of Internal Medicine, Kangnam St Mary s Hospital, The Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul, 137 701, South Korea
    Hepatol Int 2:63-71. 2008
    ..Thy1-positive bone marrow stem cells may represent preexisting hepatocyte-specific stem cells...
  47. ncbi 308 isolation, differentiation, and immunophenotypic characterization of mesenchymal stem cells derived from equine adipose tissue and bone marrow
    E Iacono
    University of Bologna, Italy
    Reprod Fertil Dev 23:250-1. 2011
    ..MSC) are a) adhesion to the plastic when maintained under culture conditions; b) expression of CD105, CD73, and CD90, and no expression for CD45, CD34, and CD14; and c) differentiation into osteoblasts, adipocytes, and chondroblasts ..
  48. ncbi Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis
    Andrea Hartner
    Medizinische Klinik IV, Universität Erlangen Nuremberg, Erlangen, Germany
    J Mol Med (Berl) 81:32-42. 2003
    ..1 nephritis. These results are in keeping with the notion that TGF-beta(2) and its receptors participate in the pathogenesis and/or resolution of this transient form of glomerulonephritis...
  49. ncbi Deletion of self-reactive T cells in nude mice grafted with neonatal allogeneic thymus
    H Yuuki
    Department of Immunology, Kyushu University, Fukuoka, Japan
    J Immunol 144:474-9. 1990
    ....
  50. ncbi [Growth inhibitory effects of THY1 gene on epithelial ovarian cancer SKOV3 cells]
    Li qin Zeng
    Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu 610041, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:84-7, 91. 2007
    ..To construct THY1 eukaryotic expression plasmid and study its effects on the growth of epithelial ovarian cancer cell line SKOV3...
  51. doi The roles of THY1 and integrin beta3 in cell adhesion during theca cell layer formation and the effect of follicle-stimulating hormone on THY1 and integrin beta3 localization in mouse ovarian follicles
    Saori Itami
    School of Natural Science and Ecological Awareness, Graduate School of Humanities and Sciences, Faculty of Science, Nara Women s University, Nara, Japan
    Biol Reprod 84:986-95. 2011
    ..In conclusion, THY1 might play a role in cell adhesion via binding to integrin beta3 in mouse ovaries. The present results suggest that THY1 localization may be affected by follicle-stimulating hormone in mouse ovaries...
  52. ncbi The peptides ADNF-9 and NAP increase survival and neurite outgrowth of rat retinal ganglion cells in vitro
    Wolf A Lagrèze
    Eye Hospital, Albert Ludwig Universität, Freiburg, Germany
    Invest Ophthalmol Vis Sci 46:933-8. 2005
    ..We evaluated these findings in cultures of purified rat retinal ganglion cells (RGCs) using two such peptides: ADNF-9 and NAP. In a second step, the influence of these peptides on neurite outgrowth in retinal explants was investigated...
  53. ncbi Transplantation with selected autologous peripheral blood CD34+Thy1+ hematopoietic stem cells (HSCs) in multiple myeloma: impact of HSC dose on engraftment, safety, and immune reconstitution
    M Michallet
    Service d Hématologie de l Hôpital Edouard Herriot, Lyon, France
    Exp Hematol 28:858-70. 2000
    ....
  54. doi Osteoinduction in umbilical cord- and palate periosteum-derived mesenchymal stem cells
    Montserrat Caballero
    Division of Plastic Surgery, University of North Carolina, Chapel Hill, NC 27599, USA
    Ann Plast Surg 64:605-9. 2010
    ..The presence of MSCs was determined using immunostaining and flow cytometry for cell surface markers CD73, CD90, CD105, and SSEA-4. Osteogenesis was induced using osteogenic medium...
  55. ncbi Glomerular activin A overexpression is linked to fibrosis in anti-Thy1 glomerulonephritis
    Jens Gaedeke
    Department of Nephrology, Universitatsklinikum Charite, Berlin, Germany
    Nephrol Dial Transplant 20:319-28. 2005
    ..This study was designed to identify regulators of activin A production in glomerular mesangial cells and test if activin A acts as a pro-fibrotic cytokine in mesangial cells...
  56. doi Aldose reductase deficiency improves Wallerian degeneration and nerve regeneration in diabetic thy1-YFP mice
    Yuk Shan Chen
    Department of Anatomy, The University of Hong Kong, Hong Kong SAR, China
    J Neuropathol Exp Neurol 69:294-305. 2010
    ..The thy1-YFP mice are valuable tools for further investigation of the mechanism of diabetes-associated nerve regeneration...
  57. pmc Gene expression and differentiation characteristics in mice E13.5 and E17.5 neural retinal progenitors
    Xuerong Sun
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 15:2503-14. 2009
    ..To improve the selection of the right-timing RPCs for replacement therapy, we compared the gene expression between embryonic day (E) 13.5 and E17.5 RPCs and further explored their gene expression and differentiation capacity in vitro...
  58. pmc Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells
    Farida Djouad
    INSERM Unit 475, Montpellier, France
    Arthritis Res Ther 7:R1304-15. 2005
    ..populations were negative for CD14, CD34 and CD45 expression and that both displayed equal levels of CD44, CD73, CD90 and CD105, a phenotype currently known to be characteristic of BM-MSC...
  59. ncbi Activation of STAT3/Smad1 is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis
    Toshikazu Takahashi
    Department of Clinical Biology and Medicine, Course of Biological Medicine, School of Medicine, The University of Tokushima, Tokushima, Japan
    J Biol Chem 280:7100-6. 2005
    ..These data suggest that the activation of STAT3 and Smad1 participates in the developing process of glomerulosclerosis in experimental glomerulonephritis...
  60. pmc Uterine leiomyomas exhibit fewer stem/progenitor cell characteristics when compared with corresponding normal myometrium
    Henry L Chang
    Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Reprod Sci 17:158-67. 2010
    ..Whereas in normal myometrium, we observed heterogeneous expression of CD90, a cell surface marker associated the with differentiation potential of uterine fibroblasts, in leiomyomas, we ..
  61. ncbi Two populations of Thy1-positive mesenchymal cells regulate in vitro maturation of hepatic progenitor cells
    Naoko Kamo
    Dept of Surgery, Graduate School of Medicine, Kyoto Univ, Shogoin, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G526-34. 2007
    ..In conclusion, these results suggest that in vitro maturation of HPCs promoted by gp38-positive cells may be opposed by an inhibitory effect of gp38-negative cells, which likely maintain the immature, proliferative state of HPCs...
  62. doi Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice
    Matthew J Gastinger
    Department of Ophthalmology, Penn State Retina Research Group, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 49:2635-42. 2008
    ..To determine the extent of retinal ganglion cell loss and morphologic abnormalities in surviving ganglion cells in Ins2 Akita/+ diabetic mice...
  63. ncbi Experimental induction of retinal ganglion cell death in adult mice
    Y Li
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53792, USA
    Invest Ophthalmol Vis Sci 40:1004-8. 1999
    ..To overcome this limitation, the rate and mechanism of retinal ganglion cell death in mice was characterized using optic nerve crush and intravitreal injections of the glutamate analog N-methyl-D-aspartate (NMDA)...
  64. ncbi Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat
    Matthias Schaier
    Department of Nephrology, University Hospital, University of Heidelberg, Bergheimer Strasse 56a, 69115, Heidelberg, Germany
    J Mol Med (Berl) 82:116-25. 2004
    ..Receptor-specific retinoids may provide a novel therapeutic approach for the treatment of chronic glomerulonephritis...
  65. doi Polychromatic flow cytometry analysis of CD34+ hematopoietic stem cells in cryopreserved early preterm human cord blood samples
    F D'Alessio
    CEINGE Biotecnologie Avanzate, Naples, Italy
    Cytometry A 79:14-24. 2011
    ..Within the CD34(Pos)CD45(Dim) population, we examined the expression of CD29, CD31, CD38, CD90, CD117, CD133, CD135, CD200, CD243, and CD338...
  66. ncbi Prolonged antigen presentation, APC-, and CD8+ T cell turnover during mycobacterial infection: comparison with Listeria monocytogenes
    Henk van Faassen
    Laboratory of Cellular Immunology, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
    J Immunol 172:3491-500. 2004
    ..Relative to LM-OVA, the dendritic cells in BCG-OVA-infected mice were apoptotic for prolonged periods, suggesting that the rapid death of APCs may limit the magnitude of Ag presentation during chronic stages of mycobacterial infection...
  67. doi Enrichment and characterization of Thy1-positive male germline stem cells (mGSCs) from dairy goat (Capra hircus) testis using magnetic microbeads
    Jiang Wu
    College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering and Technology, Key Lab for Animal Biotechnology of Agriculture Ministry of China, Northwest A and F University, Yangling, Shaanxi, China
    Theriogenology 80:1052-60. 2013
    ..Collectively, these results indicate that THY1 is a marker of undifferentiated spermatogonia in goat testes, the technique of magnetic-activated cell sorting using Thy1 antibody could be an efficient method to enrich mGSCs in goat. ..
  68. doi Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma
    Katharina Ochs
    Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Neuroimmunol 265:106-16. 2013
    ..we demonstrate that FACS-sorted malignant glioma-derived pericytes (HMGP) were characterized by the expression of CD90, CD248, and platelet-derived growth factor receptor-β (PDGFR-β)...
  69. pmc T cells are required for the peripheral phase of B-cell maturation
    Novica M Milicevic
    Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade Medical School, Belgrade, Serbia and Montenegro
    Immunology 116:308-17. 2005
    ..Our study shows that the proportion of immature B-lymphocyte subsets (CD90(high) IgM(high) and CD90(high) IgM(low)) was significantly increased, whereas that of mature B-lymphocyte subsets (..
  70. ncbi [Effects of rhG-CSF on mobilization of mouse mesenchymal stem cells]
    Qi Huan Liu
    Department of Hematology, DongFeng Hospital, Yunyang Medical College, Shiyan 442008, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:790-4. 2007
    ..The cells were collected by trypsinization and the surface antigens CD34, CD133, CD90 and CD105 were analyzed by flow cytometry...
  71. doi Soluble CD90 as a potential marker of pulmonary involvement in systemic sclerosis
    Florian Kollert
    University Medical Center, Freiburg, Germany
    Arthritis Care Res (Hoboken) 65:281-7. 2013
    ..Human CD90 is highly expressed on activated ECs and can be shed from the cell surface...
  72. doi Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study
    Linn H Nilsen
    Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
    J Neurochem 123:532-41. 2012
    ..The findings also demonstrate that in vivo (1) H MRS is a powerful tool to investigate disease-related metabolite changes in the brain...
  73. ncbi Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats
    Liliana Schaefer
    Medizinische Klinik und Poliklinik D, Wilhelm Universität Münster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Biochem Biophys Res Commun 324:247-54. 2004
    ....
  74. pmc Identification and characterization of cells with cancer stem cell properties in human primary lung cancer cell lines
    Ping Wang
    Department of Immunology, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    PLoS ONE 8:e57020. 2013
    ..Co-expression of CD90 further narrowed down the putative stem cell population in PLCCLs from SCLC and LCC as spheroid-forming cells were ..
  75. ncbi CD34+/CD90+ cells infused best predict late haematopoietic reconstitution following autologous peripheral blood stem cell transplantation
    Toshiya Sumikuma
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan
    Br J Haematol 117:238-44. 2002
    ..The relationships between the numbers of reinfused CD34+ cells and their immature subsets such as CD34+/CD90+, CD34+/AC133+, CD34+/CD38- and CD34+/HLA-DR- cells, and haemoglobin, white blood cell (WBC) and platelet counts at ..
  76. ncbi Noninvasive monitoring of diabetes-induced cutaneous nerve fiber loss and hypoalgesia in thy1-YFP transgenic mice
    Yuk Shan Chen
    Department of Anatomy, The University of Hong Kong, Hong Kong, China
    Diabetes 54:3112-8. 2005
    ..These mice will be useful for noninvasive monitoring of cutaneous nerve fiber degeneration and loss of heat-induced pain perception during diabetes and for the assessment of efficacy of therapeutic treatment of diabetic neuropathy...
  77. pmc Thy1 associates with the cation channel subunit HCN4 in adult rat retina
    Gloria J Partida
    Section of Neurobiology, Physiology, and Behavior, University ofCalifornia, Davis, California 95616 8519, USA
    Invest Ophthalmol Vis Sci 53:1696-703. 2012
    ..Because Thy1 is not a membrane-spanning protein and, instead, complexes with structural and signaling proteins in other tissues, the aim of this study was to find protein partners of retinal Thy1...
  78. ncbi Mycophenolate mofetil slows progression in anti-thy1-induced chronic renal fibrosis but is not additive to a high dose of enalapril
    Stephanie Kramer
    Department of Nephrology, Charite University Medicine Berlin, Germany
    Am J Physiol Renal Physiol 289:F359-68. 2005
    ..The dual anti-inflammatory/anti-fibrotic intervention does not yield additive renoprotective effects, indicating that MMF and enalapril interfere with similar or very closely related pathways involved in progression of renal disease...
  79. pmc How many hair follicles are innervated by one afferent axon? A confocal microscopic analysis of palisade endings in the auricular skin of thy1-YFP transgenic mouse
    Maasa Suzuki
    Department of Anatomy, Meiji University of Integrative Medicine, Kyoto, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 88:583-95. 2012
    ..Palisade endings innervated by multiple sensory neurons might be highly sensitive to hair movement...
  80. pmc PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling
    Koji Hashimoto
    Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    PPAR Res 2012:976089. 2012
    ..These findings suggest the antinephritic potential of PPARα-related medicines against MsPGN. PPARα-related medicines might be useful as a treatment option for CKD...
  81. doi Transcriptomic study of dormant gastrointestinal cancer stem cells
    Shimpei Nishikawa
    Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Int J Oncol 41:979-84. 2012
    ..CD13-/CD90+ proliferating liver CSCs are sensitive to chemotherapy, and CD13+/CD90- dormant CSCs have a limited ..
  82. doi STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF
    Dmitri V Pechkovsky
    UBC James Hogg Research Centre, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Pathol 180:1398-412. 2012
    ..and activation, including expression of α-smooth muscle actin (α-SMA), collagen, and adhesion molecules Thy-1/CD90 and α(v) β(3) and β(5) integrins...
  83. doi The efficiency of in vitro isolation and myogenic differentiation of MSCs derived from adipose connective tissue, bone marrow, and skeletal muscle tissue
    Fatma Y Meligy
    Division of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    In Vitro Cell Dev Biol Anim 48:203-15. 2012
    ..AD-MSCs showed the highest proliferation rate while BM-MSCs had the lowest one. In ICC, isolated MSCs had strong CD90- and CD44-positive expression and negative expression of CD45, CD31, and CD34, while AZA-treated MSCs had strong ..
  84. pmc Characterization of mesenchymal progenitor cells isolated from human bone marrow by negative selection
    Ulrike I Mödder
    Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Bone 50:804-10. 2012
    ..have been used to identify marrow mesenchymal populations (alkaline phosphatase [AP], Stro-1, CD29, CD49a, CD73, CD90, CD105, CD166, CD44, CD146 and CD271) may be expressed on distinct subsets of marrow mesenchymal cells...
  85. doi Enhancement of mesenchymal stem cell attachment to decellularized porcine aortic valve scaffold by in vitro coating with antibody against CD90: a preliminary study on antibody-modified tissue-engineered heart valve
    Xiaofeng Ye
    Department of Cardiac Surgery, Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, P R China
    Tissue Eng Part A 15:1-11. 2009
    ..The current study examined the feasibility of conjugating antibody against CD90 to a decellularized porcine aortic valve scaffold and binding mesenchymal stem cells to that scaffold through ..
  86. doi Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice
    H Schell
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Muller Strasse 27, Tubingen, Germany
    Neuroscience 160:796-804. 2009
    ....
  87. pmc CD90 Expression on human primary cells and elimination of contaminating fibroblasts from cell cultures
    Lynn Kisselbach
    Department of Cell Therapy, Lonza Walkersville, Inc, Walkersville, MD, 21793, USA
    Cytotechnology 59:31-44. 2009
    Cluster Differentiation 90 (CD90) is a cell surface glycoprotein originally identified on mouse thymocytes...
  88. ncbi Impact of CD133 (AC133) and CD90 expression analysis for acute leukemia immunophenotyping
    C Wuchter
    Robert Rossle Clinic, Charite, Humboldt University of Berlin, Lindenberger Weg 80, 13125 Berlin, Germany
    Haematologica 86:154-61. 2001
    ..CD133 expression was compared with CD90(Thy-1) expression, another CD34-associated antigen.
  89. ncbi Transgenic mice expressing surface markers for IFN-gamma and IL-4 producing cells
    S Hsieh
    Department and Institute of Microbiology and Immunology, National Yang Ming University School of Medicine, 11221, Taipei, Taiwan, ROC
    Mol Immunol 37:281-93. 2000
    ..These surface markers should permit isolation of viable cells according to their T(H) type for adoptive transfer experiments, and may serve as a model system for tracing the development of T(H)1 and T(H)2-type cells in vivo...
  90. ncbi In vivo identification of the mitogen-activated protein kinase cascade as a central pathogenic pathway in experimental mesangioproliferative glomerulonephritis
    Dirk Bokemeyer
    Medical Policlinic, Division of Nephrology, University of Bonn, Bonn, Germany
    J Am Soc Nephrol 13:1473-80. 2002
    ..These observations point to ERK as a putative intracellular mediator of the proliferative response in GN and suggest that pharmacologic treatments that interfere with the activation of ERK may be of potential therapeutic interest...
  91. doi Expression of extracellular matrix genes during myocardial recovery from heart failure after left ventricular assist device support
    Leanne E Felkin
    Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield, Middlesex, UK
    J Heart Lung Transplant 28:117-22. 2009
    ....
  92. doi Flow cytometric characterization of culture expanded multipotent mesenchymal stromal cells (MSCs) from horse adipose tissue: towards the definition of minimal stemness criteria
    L Pascucci
    Department of Biopathological Science and Animal and Food Hygiene, University of Perugia Via San Costanzo, 4, 06126 Perugia, Italy
    Vet Immunol Immunopathol 144:499-506. 2011
    ..In this study, we used flow cytometry to evaluate the expression of several molecules related to stemness (CD90, CD44, CD73 and STRO-1) in undifferentiated, early-passaged MSCs isolated from adipose tissue of four donor horses (..
  93. ncbi Phenotypic characterization of regulatory CD4+CD25+ T cells in rats
    Leigh A Stephens
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Int Immunol 16:365-75. 2004
    ..have a more mature phenotype than the corresponding CD4(+)CD8(-)CD25(-) cells with respect to expression of Thy1 (CD90), CD53 and CD44, suggesting that CD25 expression, and perhaps commitment to regulatory function, might be a late ..
  94. pmc Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon
    Ken Berglund
    Department of Neurobiology, Duke University Medical Center, 3209, Durham, NC 27710, USA
    Brain Cell Biol 36:101-18. 2008
    ....
  95. doi Alterations in CD4+, CD8+, Vgamma3, Vgammadelta, and/or Valpha betaT-lymphocyte expression in lymphoid tissues of progeny after in utero exposure to benzo(alpha)pyrene
    P Urso
    Department of Microbiology and Immunology, The Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunotoxicol 5:293-306. 2008
    ....
  96. doi Stromal vascular progenitors in adult human adipose tissue
    Ludovic Zimmerlin
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Cytometry A 77:22-30. 2010
    ..These markers were used in multiparameter flow cytometry in conjunction with stem/progenitor markers (CD90 and CD117) to further characterize stromal vascular fraction (SVF) subpopulations...
  97. doi Cyan fluorescent protein (CFP) expressing cells in the retina of Thy1-CFP transgenic mice before and after optic nerve injury
    Xu Wang
    Retina and Optic Nerve Research Laboratory, Dalhousie University, Halifax, Nova Scotia, Canada
    Neurosci Lett 468:110-4. 2010
    ..In retinas of Thy1-CFP mice, CFP is expressed by the large majority of RGCs, but not exclusively by RGCs. CFP is internalized by phagocytosing cells after injury to RGCs...
  98. ncbi Induction of TGF-beta1 by the matricellular protein SPARC in a rat model of glomerulonephritis
    J A Bassuk
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195 7420, USA
    Kidney Int 57:117-28. 2000
    ..Induction of TGF-beta1 by the matricellular protein SPARC in a rat model of glomerulonephritis...
  99. pmc Thy1+ NK [corrected] cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes
    Geoffrey O Gillard
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 7:e1002141. 2011
    ..These results demonstrate that a defined innate memory cell population alone can provide host protection against a lethal systemic infection through viral clearance...
  100. pmc MicroRNA-21 regulates the self-renewal of mouse spermatogonial stem cells
    Zhiyv Niu
    Department of Animal Biology, School of Veterinary Medicine, and Penn Bioinformatics Core, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:12740-5. 2011
    ..Moreover, we show that in SSC-enriched germ cell cultures, miR-21 is regulated by the transcription factor ETV5, known to be critical for SSC self-renewal...

Research Grants70

  1. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2003
    ....
  2. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..hypotheses, three specific aims are proposed: 1) Selection of epidermal SSCs by high expression of 06 integrin, CD90, low expression of receptors for EGF and transferrin (CD71), and preservation of the SSC phenotype by low amounts ..
  3. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..hypotheses, three specific aims are proposed: 1) Selection of epidermal SSCs by high expression of 06 integrin, CD90, low expression of receptors for EGF and transferrin (CD71), and preservation of the SSC phenotype by low amounts ..
  4. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard Phipps; Fiscal Year: 2009
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  5. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard Phipps; Fiscal Year: 2007
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  6. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard Phipps; Fiscal Year: 2009
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  7. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2010
    ..Cluster analysis should provide insight as to whether there are interneuron cell types that are more structurally plastic than others, and whether subsets of interneurons exhibit structural plasticity correlated with OD plasticity. ..
  8. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2011
    ..Cluster analysis should provide insight as to whether there are interneuron cell types that are more structurally plastic than others, and whether subsets of interneurons exhibit structural plasticity correlated with OD plasticity. ..
  9. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard P Phipps; Fiscal Year: 2010
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  10. NERVE ALLOTRANSPLANTATION FOR TRAUMATIC NERVE INJURY
    Susan Mackinnon; Fiscal Year: 2007
    ..In aim 3c this same construct is evaluated in a long swine allograft model that closely resembles the long nerve defects encountered clinically and will allow translation to the nerve-injured patient. ..
  11. NERVE ALLOTRANSPLANTATION FOR TRAUMATIC NERVE INJURY
    Susan E Mackinnon; Fiscal Year: 2010
    ..In aim 3c this same construct is evaluated in a long swine allograft model that closely resembles the long nerve defects encountered clinically and will allow translation to the nerve-injured patient. ..
  12. ANALYSIS OF CD8 T CELL RESPONSES TO TUMORS
    Richard Dutton; Fiscal Year: 2003
    ..We will determine what controls the growth in mice with low initial tumor load and will test the hypothesis that either CD4 or CD8 populations have a role in the control of the tumor cells. ..
  13. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2005
    ..abstract_text> ..
  14. CD4 Regulator T Cells Suppress Alloreactivity after BMT
    Bryon Johnson; Fiscal Year: 2005
    ..The information obtained will contribute significantly to our understanding of the role of regulatory T cells in mediating dominant peripheral tolerance after allo-BMT and could lead to translational applications in clinical BMT. ..
  15. Gene Therapy Reduction of Radiotherapy Esophagitis
    Joel Greenberger; Fiscal Year: 2005
    ..These studies should identify the critical cells involved in irradiation esophagitis, define the mechanism of irradiation killing and potential for protection by antioxidant transgene therapy. ..
  16. FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
    Terry Smith; Fiscal Year: 2006
    ..We believe that the results of the proposed studies will lead to important insights concerning the pathogenesis of TAO and potentially define therapeutic targets for interrupting this disease. ..
  17. PROTECTION FROM VIRAL GASTROENTERITIS BY INTESTINAL CTLS
    Paul Offit; Fiscal Year: 1993
    ..Adaptation of murine rotaviruses to growth in tissue culture allows for an accurate determination of the virus dose used for in vitro and in vivo studies...
  18. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    Clifford J Woolf; Fiscal Year: 2010
    ....