CD90

Summary

Gene Symbol: CD90
Description: Thy-1 cell surface antigen
Alias: CD90, CDw90, Thy-1 T-cell antigen, thy-1 antigen, thy-1 membrane glycoprotein
Species: human

Top Publications

  1. ncbi Augmentation of the resistance against Listeria monocytogenes by oral administration of a hot water extract of Chlorella vulgaris in mice
    T Hasegawa
    Laboratory of Germfree Life, Nagoya University School of Medicine, Japan
    Immunopharmacol Immunotoxicol 16:191-202. 1994
  2. ncbi Exogenous interleukin-3 enhances IL-4 production by splenic CD4+ cells during the early stages of a Trichinella spiralis infection
    M Korenaga
    Department of Parasitology, Kochi Medical School, Kochi, Japan
    Int Arch Allergy Immunol 117:131-7. 1998
  3. pmc Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes
    Laura Koumas
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 163:1291-300. 2003
  4. pmc Does the human skeletal muscle harbor the murine equivalents of cardiac precursor cells?
    Susanne Proksch
    INSERM U 633, Laboratory of Biosurgical Research, Hopital Broussais, Paris, France
    Mol Ther 17:733-41. 2009
  5. ncbi Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium
    Anja Saalbach
    Saxon Academy of Science, D 04107 Leipzig, Germany
    Oncogene 24:4710-20. 2005
  6. ncbi Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity
    Thomas H Barker
    Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Exp Cell Res 295:488-96. 2004
  7. ncbi Characterization of alphaX I-domain binding to Thy-1
    Jeongsuk Choi
    Divisions of Science Education and Biology, Kangwon National University, Choonchun, Kangwon, Republic of Korea
    Biochem Biophys Res Commun 331:557-61. 2005
  8. ncbi Human Thy-1 induces secretion of matrix metalloproteinase-9 and CXCL8 from human neutrophils
    Anja Saalbach
    Department of Dermatology, Venerology and Allergology, Medical Faculty of the Leipzig University, Leipzig, Germany
    Eur J Immunol 38:1391-403. 2008
  9. ncbi An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer
    Xianglan Zhang
    Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120 752, Korea
    Int J Oncol 36:405-14. 2010
  10. pmc Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes
    Laura E Pascal
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    BMC Cancer 9:317. 2009

Research Grants

  1. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2003
  2. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
  3. Investigating Cell Specific Roles of the Complement Cascade in Glaucoma
    Gareth R Howell; Fiscal Year: 2013
  4. Astrocytic Ca2+ Signaling in the Ischemic Penumbra
    Maiken Nedergaard; Fiscal Year: 2011
  5. Environmental obesogens reduce Thy1 expression and promote obesity
    Richard P Phipps; Fiscal Year: 2013
  6. The Gut Microbiome in Neurodegenerative Disease
    Sarkis K Mazmanian; Fiscal Year: 2013
  7. Non-viral gene therapy for sickle cell anemia
    CLIFFORD JOHN STEER; Fiscal Year: 2010
  8. Non-viral gene therapy for sickle cell anemia
    Robert Hebbel; Fiscal Year: 2009
  9. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2007
  10. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009

Detail Information

Publications174 found, 100 shown here

  1. ncbi Augmentation of the resistance against Listeria monocytogenes by oral administration of a hot water extract of Chlorella vulgaris in mice
    T Hasegawa
    Laboratory of Germfree Life, Nagoya University School of Medicine, Japan
    Immunopharmacol Immunotoxicol 16:191-202. 1994
    ....
  2. ncbi Exogenous interleukin-3 enhances IL-4 production by splenic CD4+ cells during the early stages of a Trichinella spiralis infection
    M Korenaga
    Department of Parasitology, Kochi Medical School, Kochi, Japan
    Int Arch Allergy Immunol 117:131-7. 1998
    ..IL-4 production was suppressed in rIL-3-treated mice injected with anti-CD4 mAb. These results suggest that IL-3 might play a role as Th2 amplifier in immune response to parasite infection...
  3. pmc Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes
    Laura Koumas
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 163:1291-300. 2003
    ....
  4. pmc Does the human skeletal muscle harbor the murine equivalents of cardiac precursor cells?
    Susanne Proksch
    INSERM U 633, Laboratory of Biosurgical Research, Hopital Broussais, Paris, France
    Mol Ther 17:733-41. 2009
    ..Skeletal muscle biopsies obtained from 39 patients were sorted by flow cytometry which generated three populations (CD90+/CD34(-), CD34+/CD90(-), CD90(-)/CD34(-)) expressing similar levels of cardiac (Nkx2...
  5. ncbi Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium
    Anja Saalbach
    Saxon Academy of Science, D 04107 Leipzig, Germany
    Oncogene 24:4710-20. 2005
    ..These data explain at least in part the high tumorigenicity of alphavbeta3-expressing melanoma cells and the association of alphavbeta3-positive melanoma cells with a high risk of metastasis and poor prognosis...
  6. ncbi Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity
    Thomas H Barker
    Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Exp Cell Res 295:488-96. 2004
    ..We therefore conclude that Thy-1 surface expression regulates fibroblast focal adhesions, cytoskeletal organization and migration by modulating the activity of p190 RhoGAP and Rho GTPase...
  7. ncbi Characterization of alphaX I-domain binding to Thy-1
    Jeongsuk Choi
    Divisions of Science Education and Biology, Kangwon National University, Choonchun, Kangwon, Republic of Korea
    Biochem Biophys Res Commun 331:557-61. 2005
    ..Given the reported role of Thy-1 in the regulation of T cell homeostasis and proliferation, it is tempting to speculate that alphaX-beta2 may be involved in Thy-1 function...
  8. ncbi Human Thy-1 induces secretion of matrix metalloproteinase-9 and CXCL8 from human neutrophils
    Anja Saalbach
    Department of Dermatology, Venerology and Allergology, Medical Faculty of the Leipzig University, Leipzig, Germany
    Eur J Immunol 38:1391-403. 2008
    ..Our results support the general concept that the function of 'adhesion molecules' in particular of human Thy-1, may not only be to provide mechanical support but also regulate neutrophil functions...
  9. ncbi An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer
    Xianglan Zhang
    Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120 752, Korea
    Int J Oncol 36:405-14. 2010
    ..Mechanism-wise GPX3 down-regulation in gastric cancer is due to promoter hypermethylation. Collectively, these results show a correct identification of 8 genes as gastric cancer biomarkers...
  10. pmc Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes
    Laura E Pascal
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    BMC Cancer 9:317. 2009
    ..The tumor-associated stroma is marked by increased expression of CD90/THY1...
  11. ncbi Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
    Anne Wetzel
    Department of Dermatology, University of Leipzig, Leipzig, Germany
    J Immunol 172:3850-9. 2004
    ..In our previous work, the human Ig superfamily glycoprotein Thy-1 (CD90) was identified as an activation-associated cell adhesion molecule on human dermal microvascular endothelial cells...
  12. pmc Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts
    Hongjuan Zhao
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    Prostate 69:991-1000. 2009
    Cancer-associated stroma contributes to the malignant behavior of adenocarcinomas of the prostate and other organs. CD90 is a marker of mesenchymal stem cells (MSCs) and its expression is higher in prostate cancer stroma compared to ..
  13. ncbi The Thy-1/Thy-1 ligand interaction is involved in binding of melanoma cells to activated Thy-1- positive microvascular endothelial cells
    A Saalbach
    Department of Dermatology, University of Leipzig, 04103 Leipzig, Germany
    Microvasc Res 64:86-93. 2002
    ....
  14. pmc The human Thy-1 gene: structure and chromosomal location
    T Seki
    Proc Natl Acad Sci U S A 82:6657-61. 1985
    ..The structural gene for human Thy-1 was localized to the long arm of chromosome 11 by nucleic acid hybridization to genomic DNA isolated from somatic cell hybrids...
  15. ncbi CD34(+) cell subsets and long-term culture colony-forming cells evaluated on both autologous and normal bone marrow stroma predict long-term hematopoietic engraftment in patients undergoing autologous peripheral blood stem cell transplantation
    F Lanza
    Section of Hematology and BMT Unit, Department of Biomedical Sciences and Advanced Therapies, University Hospital, Ferrara, Italy
    Exp Hematol 29:1484-93. 2001
    ....
  16. ncbi Enhancement of immunoglobulin A production in Peyer's patches by oral administration of a traditional Chinese medicine, xiao-chai-hu-tang (Shosaiko-to)
    Y Tauchi
    Traditional Chinese Medicine Research Laboratories, Kanebo, Ltd, Osaka, Japan
    Immunopharmacol Immunotoxicol 15:251-72. 1993
    ..2-TcR alpha beta+T cells in the mesenteric lymph nodes were slight increased. These results showed that orally administered Shosaiko-to acts as a polyclonal B-cell activator which induces IgA production in the mucosal immune system...
  17. ncbi A system for inducible gene expression in retinal ganglion cells
    John B Kerrison
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 46:2932-9. 2005
    ..To develop a system for inducible gene expression in retinal ganglion cells, Thy1 and ckit promoters were used to direct expression of a second-generation reverse tetracycline transactivator (rtTA2S-M2)...
  18. ncbi T-cell-activating monoclonal antibodies, reacting with both leukocytes and erythrocytes, recognize the guinea pig Thy-1 differentiation antigen: characterization and cloning of guinea pig CD90
    H Schafer
    Department of Immunology, Robert Koch Institute, Berlin, Germany
    Cell Immunol 197:116-28. 1999
    ..by immunoadsorption and microsequencing revealed that this T-cell-activating protein is the homologue of Thy-1 or CD90. In contrast to the Thy-1 antigen of most other species, guinea pig Thy-1 has a much higher molecular weight, which ..
  19. doi A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs
    Diana Campioni
    Hematology Section, University, St Anna Hospital, Corso Giovecca n 203, Ferrara, Italy
    Cytometry B Clin Cytom 76:225-30. 2009
    ..The CD90+ hMSC reduced lymphoproliferative response in phytohemagglutinin (PHA) activated peripheral blood mononuclear cells ..
  20. ncbi Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 12:2300-9. 2001
    ..It was concluded that the beneficial effects of retinoids on glomerular damage are presumably due to a marked reduction in renal TGF-beta 1 and TGF receptor II expression...
  21. ncbi Expression of CX3CL1/fractalkine by mesangial cells in vitro and in acute anti-Thy1 glomerulonephritis in rats
    Yung Ming Chen
    Department of Internal Medicine, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei 10016, Taiwan
    Nephrol Dial Transplant 18:2505-14. 2003
    ..This study investigated the potential of MCs to synthesize CX3CL1/fractalkine, a CX3C chemokine, both in vitro and in acute anti-Thy1 glomerulonephritis in rats...
  22. ncbi Experimental African trypanosomiasis: a subset of pathogenic, IFN-gamma-producing, MHC class II-restricted CD4+ T cells mediates early mortality in highly susceptible mice
    Meiqing Shi
    Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
    J Immunol 176:1724-32. 2006
    ..We speculate that IL-10-producing CD4+ T cells might counteract this effect...
  23. doi Bone marrow cells immunomagnetically selected for CD271+ antigen promote in vitro the repair of articular cartilage defects
    Tamara Hermida-Gómez
    Biomedical Research Center, INIBIC Hospital Universitario A Coruña, University of A Coruna, A Coruna, Spain
    Tissue Eng Part A 17:1169-79. 2011
    ....
  24. ncbi NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritis
    Harm Peters
    Division of Nephrology and Institute of Pathology, Charite, Campus Mitte, Humboldt University, Berlin, Germany
    Kidney Int 64:509-18. 2003
    ..NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritis...
  25. ncbi Antibody-induced albuminuria and accelerated focal glomerulosclerosis in the Thy-1.1 transgenic mouse
    Karel J M Assmann
    Department of Pathology, Division of Nephrology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Kidney Int 62:116-26. 2002
    ..1 transgenic mouse. This mouse expresses a hybrid human-mouse Thy-1.1 antigen on the podocytes, and slowly but spontaneously develops albuminuria and focal glomerulosclerosis...
  26. doi Differentiation of synovial CD-105(+) human mesenchymal stem cells into chondrocyte-like cells through spheroid formation
    M C Arufe
    Osteoarticular and Aging Research Laboratory, Cell Therapy Unit Biomedical Research Center, INIBIC Hospital Universitario A Coruña, Coruna, Spain
    J Cell Biochem 108:145-55. 2009
    ..studies have used the total population of MSCs, including cells with several MSC markers, such as CD44, CD90, CD105, or CD73. However the chondrogenic capacity of an individual population of MSCs has not been examined...
  27. ncbi Changes in the populations of null, NK1.1+, and Thy1lo lymphocytes in the bone marrow of tumor-bearing mice: effect of indomethacin treatment
    M D Rahal
    Department of Anatomy, McGill University, Montreal, Quebec, Canada
    Cell Immunol 139:218-28. 1992
    ..The results suggest that the production of null lymphocytes in mouse bone marrow is responsive to tumor development, possibly providing cells to be involved in tumor-host interactions...
  28. pmc Progressive damage along the optic nerve following induction of crush injury or rodent anterior ischemic optic neuropathy in transgenic mice
    O Dratviman-Storobinsky
    The Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Tel Aviv University, Petah Tiqwa, Israel
    Mol Vis 14:2171-9. 2008
    ..To characterize the histological changes that occur in response to induction of ischemic or mechanical optic nerve damage in transgenic mice...
  29. ncbi Neonatal estrogen treatment and its consequences for thymus development, serum level of autoantibodies to cardiolipin, and the delayed-type hypersensitivity response
    J G Forsberg
    Tornblad Institute, University of Lund, Sweden
    J Toxicol Environ Health A 60:185-213. 2000
    ..2 marker or percentages of CD4+/CD8+ DP or SP subsets in thymus and spleen, qualitative and quantitative differences occur in immune parameters (autoantibodies to cardiolipin) and a T-cell-dependent immune response (DTH)...
  30. ncbi Induction of tumoricidal macrophages from bone marrow cells of normal mice or mice bearing a colony-stimulating-factor-producing tumor
    S Hosoe
    Third Department of Internal Medicine, Osaka University Medical School, Japan
    Cancer Immunol Immunother 28:116-22. 1989
    ..These results strongly suggest that M-CSF plays an important role not only in the maturation of macrophage progenitors but also in the induction and the accumulation of activated macrophages...
  31. ncbi [Expression of THY1 gene in epithelial ovarian cancer]
    Li qin Zeng
    Department of Gynecology, Guangdong Women s and Children s Hospital and Health Institute, Guangzhou 510010, China
    Zhonghua Zhong Liu Za Zhi 31:118-20. 2009
    ..To detect the expession of THY1 in ovarian serous cystadenocarcinoma tissues...
  32. pmc Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium
    Giorgia Jurisic
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Exp Cell Res 316:2982-92. 2010
    ..mouse intestinal lymphatic endothelial cells versus blood vascular endothelial cells, thymus cell antigen 1 (Thy1, CD90) was expressed at much higher levels in lymphatic endothelial cells than in blood vascular endothelial cells...
  33. doi Cellular volume and marker expression in human peripheral blood apheresis stem cells
    Siddharth Sharma
    Department of Pathology, University of Miami Miller School of Medicine, Sylvester Cancer Center, Miami, Florida 33101, USA
    Cytometry A 73:160-7. 2008
    ..solution), or processed by Ficoll Hypaque sedimentation method were stained with CD45-FITC and PE-labeled CD34, CD90, CD117, and CD133 antibodies and analyzed for electronic volume and two color fluorescence...
  34. ncbi Persistent infection of mice by lactate dehydrogenase-elevating virus: effects of immunosuppression on virus replication and antiviral immune responses
    C O Onyekaba
    Department of Microbiology, Medical School University of Minnesota, Minneapolis 55455
    Virus Res 14:297-315. 1989
    ..The steady-state viremia attained about 5 weeks after infection reflects a balance between LDV replication in permissive macrophages as they arise and LDV inactivation and clearance...
  35. pmc Archaeal Pyrococcus furiosus thymidylate synthase 1 is an RNA-binding protein
    Akio Kanai
    Institute for Advanced Biosciences, Keio University, Tsuruoka, 997 0017, Japan
    Biochem J 393:373-9. 2006
    ....
  36. ncbi Retinoic acid reduces glomerular injury in a rat model of glomerular damage
    J Wagner
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 11:1479-87. 2000
    ..001). It is concluded that all-trans-RA limits glomerular proliferation, glomerular lesions, and albuminuria in an established model of renal damage. The findings point to retinoids as potential novel modulators of glomerular injury...
  37. ncbi Kinetics of adaptive immunity to Haemophilus influenzae type b meningitis in transgenic mice: evidence from diverse expression of double T1/T2 transgenes and Th1/Th2-related cytokines
    Shyi Jou Chen
    The Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
    Immunol Lett 105:6-15. 2006
    ..Our results support that these transgenic mice provide an available model to dissect the complex kinetic change of adaptive immunity in bacterial infectious diseases...
  38. ncbi The characterization of the monoclonal antibody Th-10a, specific for a nuclear protein appearing in the S phase of the cell cycle in normal thymocytes and its unregulated expression in lymphoma cell lines
    M Muto
    Division of Biology and Oncology, National Institute of Radiological Science, Chiba, Japan
    Cell Prolif 28:645-57. 1995
    ..The nuclear protein(s) detected by Th-10a monoclonal antibody was mostly 95 kDa and also 83 kDa polypeptide. The results also indicated that the 95 kDa nuclear protein was phosphorylated in vivo...
  39. ncbi Expression of CD90 on keratinocyte stem/progenitor cells
    Y Nakamura
    Division of Hematopoiesis, Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Br J Dermatol 154:1062-70. 2006
    ..Here, we report the detection of CD90(+) cells in cultured normal human epidermal keratinocytes and adult skin.
  40. ncbi Signal transduction involved in protective effects of 15(R/S)-methyl- lipoxin A(4) on mesangioproliferative nephritis in rats
    Sheng Hua Wu
    Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China
    Prostaglandins Leukot Essent Fatty Acids 76:173-80. 2007
    ..1 antibodies. Protective effects of 15(R/S)-methyl-LXA(4) on nephritis induced by anti-Thy1.1 antibodies were related to PI3-K/Akt(1)/p27(kip1)/cyclin pathway, STAT(3) and NF-kappaB pathway-dependent signal transduction...
  41. doi Intra-bone marrow cotransplantation of donor mesenchymal stem cells in pig-to-NOD/SCID mouse bone marrow transplantation facilitates short-term xenogeneic hematopoietic engraftment
    H Eguchi
    Center for International Relations, Osaka University Graduate School of Medicine, Osaka, Japan
    Transplant Proc 40:574-7. 2008
    ..Porcine MSC prepared by aspiration of iliac BM of miniature swine were identified as CD90+CD29+CD45-CD31- and shown to differentiate into osteoblastocytes and adipocytes...
  42. ncbi Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivo
    C P Hugo
    Division of Nephrology, Universitat Erlangen Nurnberg, Erlangen, Germany
    Kidney Int 55:2236-49. 1999
    ....
  43. ncbi Longitudinal profile of retinal ganglion cell damage assessed with blue-light confocal scanning laser ophthalmoscopy after ischaemic reperfusion injury
    C K S Leung
    Hamilton Glaucoma Center, University of California, San Diego, La Jolla, CA 92093 0946, USA
    Br J Ophthalmol 93:964-8. 2009
    ....
  44. ncbi [Influence of co-culturing vascular endothelial cells and adipose-derived stromal cells on osteogenic differentiation in vitro]
    Fuke Wang
    Department of Head and Neck Surgery, the 1st Affiliated Hospital of Kunming Medical College, Kunming Yunnan, 650032, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:399-405. 2010
    ....
  45. ncbi Graft-vs-leukemia activity and graft-vs-host disease induced by allogeneic Th1- and Th2-type CD4+ T cells in mice
    M Zeis
    2nd Department of Internal Medicine, University of Kiel, Kiel, Germany
    Hematol J 2:136-44. 2001
    ..Therefore, separation of GVL- and GVH-reactions is a long-standing goal of experimental studies dealing with allogeneic transplantation of hematopoietic stem cells...
  46. ncbi [T lymphocytes are necessary for the peripheral phase of B lymphocyte maturation]
    Novica M Milicevic
    Institute of Histology and Embryology Aleksandar D Kostic, School of Medicine, University of Belgrade, Belgrade
    Srp Arh Celok Lek 136:166-70. 2008
    ..We showed that the proportion of immature B lymphocyte subsets (CD90(high)IgM(high) and CD90(high)IgM(low)) was significantly increased, whereas that of mature B lymphocyte subsets (..
  47. ncbi Polysaccharide (ANK-102) from Polianthes tuberosa cells deteriorates the resistance of mice to Listeria monocytogenes infection
    T Majima
    Department of Ontogeny and Development, Tohoku University, Sendai, Japan
    Immunopharmacol Immunotoxicol 17:59-68. 1995
    ..2 expression on the surface of the thymocytes. A new type of immunosuppressive polysaccharide ANK-102 was introduced...
  48. pmc Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis
    Christian A Seemayer
    Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Switzerland
    Am J Pathol 162:1549-57. 2003
    ....
  49. ncbi Endogenous and adoptively transferred A-NK and T-LAK cells continuously accumulate within murine metastases up to 48 h after inoculation
    M Hokland
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    In Vivo 13:199-204. 1999
    ..These data underline the longevity of LAK cells in vivo and highlight the importance of IL-2 treatment in recruiting endogenous immune cells to tumor areas...
  50. ncbi Induction of regional collateral sprouting following muscle denervation
    Jason W Koob
    Departments of Plastic and Reconstructive Surgery, Washington University, Saint Louis, Missouri, USA
    Laryngoscope 117:1735-40. 2007
    ..We hypothesize that epineurial injury is required to induce collateral sprouting toward a neighboring denervated muscle...
  51. pmc Thy1-positive bone marrow stem cells express liver-specific genes in vitro and can mature into hepatocytes in vivo
    Si Hyun Bae
    Department of Internal Medicine, Kangnam St Mary s Hospital, The Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul, 137 701, South Korea
    Hepatol Int 2:63-71. 2008
    ..Thy1-positive bone marrow stem cells may represent preexisting hepatocyte-specific stem cells...
  52. ncbi 308 isolation, differentiation, and immunophenotypic characterization of mesenchymal stem cells derived from equine adipose tissue and bone marrow
    E Iacono
    University of Bologna, Italy
    Reprod Fertil Dev 23:250-1. 2011
    ..MSC) are a) adhesion to the plastic when maintained under culture conditions; b) expression of CD105, CD73, and CD90, and no expression for CD45, CD34, and CD14; and c) differentiation into osteoblasts, adipocytes, and chondroblasts ..
  53. doi The roles of THY1 and integrin beta3 in cell adhesion during theca cell layer formation and the effect of follicle-stimulating hormone on THY1 and integrin beta3 localization in mouse ovarian follicles
    Saori Itami
    School of Natural Science and Ecological Awareness, Graduate School of Humanities and Sciences, Faculty of Science, Nara Women s University, Nara, Japan
    Biol Reprod 84:986-95. 2011
    ..In conclusion, THY1 might play a role in cell adhesion via binding to integrin beta3 in mouse ovaries. The present results suggest that THY1 localization may be affected by follicle-stimulating hormone in mouse ovaries...
  54. ncbi [Growth inhibitory effects of THY1 gene on epithelial ovarian cancer SKOV3 cells]
    Li qin Zeng
    Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu 610041, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:84-7, 91. 2007
    ..To construct THY1 eukaryotic expression plasmid and study its effects on the growth of epithelial ovarian cancer cell line SKOV3...
  55. ncbi Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis
    Andrea Hartner
    Medizinische Klinik IV, Universität Erlangen Nuremberg, Erlangen, Germany
    J Mol Med (Berl) 81:32-42. 2003
    ..1 nephritis. These results are in keeping with the notion that TGF-beta(2) and its receptors participate in the pathogenesis and/or resolution of this transient form of glomerulonephritis...
  56. ncbi Deletion of self-reactive T cells in nude mice grafted with neonatal allogeneic thymus
    H Yuuki
    Department of Immunology, Kyushu University, Fukuoka, Japan
    J Immunol 144:474-9. 1990
    ....
  57. ncbi The peptides ADNF-9 and NAP increase survival and neurite outgrowth of rat retinal ganglion cells in vitro
    Wolf A Lagrèze
    Eye Hospital, Albert Ludwig Universität, Freiburg, Germany
    Invest Ophthalmol Vis Sci 46:933-8. 2005
    ..We evaluated these findings in cultures of purified rat retinal ganglion cells (RGCs) using two such peptides: ADNF-9 and NAP. In a second step, the influence of these peptides on neurite outgrowth in retinal explants was investigated...
  58. doi Osteoinduction in umbilical cord- and palate periosteum-derived mesenchymal stem cells
    Montserrat Caballero
    Division of Plastic Surgery, University of North Carolina, Chapel Hill, NC 27599, USA
    Ann Plast Surg 64:605-9. 2010
    ..The presence of MSCs was determined using immunostaining and flow cytometry for cell surface markers CD73, CD90, CD105, and SSEA-4. Osteogenesis was induced using osteogenic medium...
  59. doi Aldose reductase deficiency improves Wallerian degeneration and nerve regeneration in diabetic thy1-YFP mice
    Yuk Shan Chen
    Department of Anatomy, The University of Hong Kong, Hong Kong SAR, China
    J Neuropathol Exp Neurol 69:294-305. 2010
    ..The thy1-YFP mice are valuable tools for further investigation of the mechanism of diabetes-associated nerve regeneration...
  60. ncbi Glomerular activin A overexpression is linked to fibrosis in anti-Thy1 glomerulonephritis
    Jens Gaedeke
    Department of Nephrology, Universitatsklinikum Charite, Berlin, Germany
    Nephrol Dial Transplant 20:319-28. 2005
    ..This study was designed to identify regulators of activin A production in glomerular mesangial cells and test if activin A acts as a pro-fibrotic cytokine in mesangial cells...
  61. ncbi Transplantation with selected autologous peripheral blood CD34+Thy1+ hematopoietic stem cells (HSCs) in multiple myeloma: impact of HSC dose on engraftment, safety, and immune reconstitution
    M Michallet
    Service d Hématologie de l Hôpital Edouard Herriot, Lyon, France
    Exp Hematol 28:858-70. 2000
    ....
  62. ncbi Experimental induction of retinal ganglion cell death in adult mice
    Y Li
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53792, USA
    Invest Ophthalmol Vis Sci 40:1004-8. 1999
    ..To overcome this limitation, the rate and mechanism of retinal ganglion cell death in mice was characterized using optic nerve crush and intravitreal injections of the glutamate analog N-methyl-D-aspartate (NMDA)...
  63. pmc Gene expression and differentiation characteristics in mice E13.5 and E17.5 neural retinal progenitors
    Xuerong Sun
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 15:2503-14. 2009
    ..To improve the selection of the right-timing RPCs for replacement therapy, we compared the gene expression between embryonic day (E) 13.5 and E17.5 RPCs and further explored their gene expression and differentiation capacity in vitro...
  64. ncbi Two populations of Thy1-positive mesenchymal cells regulate in vitro maturation of hepatic progenitor cells
    Naoko Kamo
    Dept of Surgery, Graduate School of Medicine, Kyoto Univ, Shogoin, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G526-34. 2007
    ..In conclusion, these results suggest that in vitro maturation of HPCs promoted by gp38-positive cells may be opposed by an inhibitory effect of gp38-negative cells, which likely maintain the immature, proliferative state of HPCs...
  65. pmc Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells
    Farida Djouad
    INSERM Unit 475, Montpellier, France
    Arthritis Res Ther 7:R1304-15. 2005
    ..populations were negative for CD14, CD34 and CD45 expression and that both displayed equal levels of CD44, CD73, CD90 and CD105, a phenotype currently known to be characteristic of BM-MSC...
  66. pmc Uterine leiomyomas exhibit fewer stem/progenitor cell characteristics when compared with corresponding normal myometrium
    Henry L Chang
    Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Reprod Sci 17:158-67. 2010
    ..Whereas in normal myometrium, we observed heterogeneous expression of CD90, a cell surface marker associated the with differentiation potential of uterine fibroblasts, in leiomyomas, we ..
  67. ncbi Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat
    Matthias Schaier
    Department of Nephrology, University Hospital, University of Heidelberg, Bergheimer Strasse 56a, 69115, Heidelberg, Germany
    J Mol Med (Berl) 82:116-25. 2004
    ..Receptor-specific retinoids may provide a novel therapeutic approach for the treatment of chronic glomerulonephritis...
  68. doi Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice
    Matthew J Gastinger
    Department of Ophthalmology, Penn State Retina Research Group, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 49:2635-42. 2008
    ..To determine the extent of retinal ganglion cell loss and morphologic abnormalities in surviving ganglion cells in Ins2 Akita/+ diabetic mice...
  69. ncbi Activation of STAT3/Smad1 is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis
    Toshikazu Takahashi
    Department of Clinical Biology and Medicine, Course of Biological Medicine, School of Medicine, The University of Tokushima, Tokushima, Japan
    J Biol Chem 280:7100-6. 2005
    ..These data suggest that the activation of STAT3 and Smad1 participates in the developing process of glomerulosclerosis in experimental glomerulonephritis...
  70. doi Polychromatic flow cytometry analysis of CD34+ hematopoietic stem cells in cryopreserved early preterm human cord blood samples
    F D'Alessio
    CEINGE Biotecnologie Avanzate, Naples, Italy
    Cytometry A 79:14-24. 2011
    ..Within the CD34(Pos)CD45(Dim) population, we examined the expression of CD29, CD31, CD38, CD90, CD117, CD133, CD135, CD200, CD243, and CD338...
  71. ncbi Prolonged antigen presentation, APC-, and CD8+ T cell turnover during mycobacterial infection: comparison with Listeria monocytogenes
    Henk van Faassen
    Laboratory of Cellular Immunology, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
    J Immunol 172:3491-500. 2004
    ..Relative to LM-OVA, the dendritic cells in BCG-OVA-infected mice were apoptotic for prolonged periods, suggesting that the rapid death of APCs may limit the magnitude of Ag presentation during chronic stages of mycobacterial infection...
  72. doi Proteome characterization of splenocytes from an Aβpp/ps-1 Alzheimer's disease model
    Zhiyun Cao
    Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA
    Proteomics 14:291-7. 2014
    ..Herein, we report proteome characterization for two subsets of splenocytes (i.e. CD90+ cells and a heterogeneous pool of CD90- cells) from a double transgenic mutant amyloid precursor protein/..
  73. ncbi Bone morphogenetic protein-12 induces tenogenic differentiation of mesenchymal stem cells derived from equine amniotic fluid
    Baldev R Gulati
    National Research Centre on Equines, Hisar, India
    Cells Tissues Organs 198:377-89. 2013
    ..These cells expressed mesenchymal surface markers [cluster of differentiation (CD)73, CD90 and CD105] by reverse transcription (RT)-polymerase chain reaction (PCR) and immunocytochemistry, but did not ..
  74. ncbi Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein
    Sudhakar Raja Subramaniam
    Department of Neurology, David Geffen School of Medicine, UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA Electronic address
    Neurobiol Dis 70:204-13. 2014
    ..This may contribute to a higher level of oxidative stress that overwhelms antioxidant defense in these neurons, leading to their increased vulnerability in PD. ..
  75. pmc CD90+ mesothelial-like cells in peritoneal fluid promote peritoneal metastasis by forming a tumor permissive microenvironment
    Joji Kitayama
    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan
    PLoS ONE 9:e86516. 2014
    ..We found that a minor subset of human intraperitoneal cells with CD90(+)/CD45(-) phenotype vigorously grew in culture with mesothelial-like appearance...
  76. doi Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma
    Katharina Ochs
    Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Neuroimmunol 265:106-16. 2013
    ..we demonstrate that FACS-sorted malignant glioma-derived pericytes (HMGP) were characterized by the expression of CD90, CD248, and platelet-derived growth factor receptor-β (PDGFR-β)...
  77. ncbi Enrichment and characterization of Thy1-positive male germline stem cells (mGSCs) from dairy goat (Capra hircus) testis using magnetic microbeads
    Jiang Wu
    College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering and Technology, Key Lab for Animal Biotechnology of Agriculture Ministry of China, Northwest A and F University, Yangling, Shaanxi, China
    Theriogenology 80:1052-60. 2013
    ..Collectively, these results indicate that THY1 is a marker of undifferentiated spermatogonia in goat testes, the technique of magnetic-activated cell sorting using Thy1 antibody could be an efficient method to enrich mGSCs in goat. ..
  78. ncbi [Effects of rhG-CSF on mobilization of mouse mesenchymal stem cells]
    Qi Huan Liu
    Department of Hematology, DongFeng Hospital, Yunyang Medical College, Shiyan 442008, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:790-4. 2007
    ..The cells were collected by trypsinization and the surface antigens CD34, CD133, CD90 and CD105 were analyzed by flow cytometry...
  79. pmc Identification and characterization of cells with cancer stem cell properties in human primary lung cancer cell lines
    Ping Wang
    Department of Immunology, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    PLoS ONE 8:e57020. 2013
    ..Co-expression of CD90 further narrowed down the putative stem cell population in PLCCLs from SCLC and LCC as spheroid-forming cells were ..
  80. ncbi CD34+/CD90+ cells infused best predict late haematopoietic reconstitution following autologous peripheral blood stem cell transplantation
    Toshiya Sumikuma
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan
    Br J Haematol 117:238-44. 2002
    ..The relationships between the numbers of reinfused CD34+ cells and their immature subsets such as CD34+/CD90+, CD34+/AC133+, CD34+/CD38- and CD34+/HLA-DR- cells, and haemoglobin, white blood cell (WBC) and platelet counts at ..
  81. ncbi Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats
    Liliana Schaefer
    Medizinische Klinik und Poliklinik D, Wilhelm Universität Münster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Biochem Biophys Res Commun 324:247-54. 2004
    ....
  82. pmc Thy1 associates with the cation channel subunit HCN4 in adult rat retina
    Gloria J Partida
    Section of Neurobiology, Physiology, and Behavior, University ofCalifornia, Davis, California 95616 8519, USA
    Invest Ophthalmol Vis Sci 53:1696-703. 2012
    ..Because Thy1 is not a membrane-spanning protein and, instead, complexes with structural and signaling proteins in other tissues, the aim of this study was to find protein partners of retinal Thy1...
  83. doi Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study
    Linn H Nilsen
    Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
    J Neurochem 123:532-41. 2012
    ..The findings also demonstrate that in vivo (1) H MRS is a powerful tool to investigate disease-related metabolite changes in the brain...
  84. ncbi Noninvasive monitoring of diabetes-induced cutaneous nerve fiber loss and hypoalgesia in thy1-YFP transgenic mice
    Yuk Shan Chen
    Department of Anatomy, The University of Hong Kong, Hong Kong, China
    Diabetes 54:3112-8. 2005
    ..These mice will be useful for noninvasive monitoring of cutaneous nerve fiber degeneration and loss of heat-induced pain perception during diabetes and for the assessment of efficacy of therapeutic treatment of diabetic neuropathy...
  85. pmc T cells are required for the peripheral phase of B-cell maturation
    Novica M Milicevic
    Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade Medical School, Belgrade, Serbia and Montenegro
    Immunology 116:308-17. 2005
    ..Our study shows that the proportion of immature B-lymphocyte subsets (CD90(high) IgM(high) and CD90(high) IgM(low)) was significantly increased, whereas that of mature B-lymphocyte subsets (..
  86. doi Soluble CD90 as a potential marker of pulmonary involvement in systemic sclerosis
    Florian Kollert
    University Medical Center, Freiburg, Germany
    Arthritis Care Res (Hoboken) 65:281-7. 2013
    ..Human CD90 is highly expressed on activated ECs and can be shed from the cell surface...
  87. ncbi Mycophenolate mofetil slows progression in anti-thy1-induced chronic renal fibrosis but is not additive to a high dose of enalapril
    Stephanie Kramer
    Department of Nephrology, Charite University Medicine Berlin, Germany
    Am J Physiol Renal Physiol 289:F359-68. 2005
    ..The dual anti-inflammatory/anti-fibrotic intervention does not yield additive renoprotective effects, indicating that MMF and enalapril interfere with similar or very closely related pathways involved in progression of renal disease...
  88. pmc How many hair follicles are innervated by one afferent axon? A confocal microscopic analysis of palisade endings in the auricular skin of thy1-YFP transgenic mouse
    Maasa Suzuki
    Department of Anatomy, Meiji University of Integrative Medicine, Kyoto, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 88:583-95. 2012
    ..Palisade endings innervated by multiple sensory neurons might be highly sensitive to hair movement...
  89. doi Transcriptomic study of dormant gastrointestinal cancer stem cells
    Shimpei Nishikawa
    Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Int J Oncol 41:979-84. 2012
    ..CD13-/CD90+ proliferating liver CSCs are sensitive to chemotherapy, and CD13+/CD90- dormant CSCs have a limited ..
  90. pmc PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling
    Koji Hashimoto
    Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    PPAR Res 2012:976089. 2012
    ..These findings suggest the antinephritic potential of PPARα-related medicines against MsPGN. PPARα-related medicines might be useful as a treatment option for CKD...
  91. doi The efficiency of in vitro isolation and myogenic differentiation of MSCs derived from adipose connective tissue, bone marrow, and skeletal muscle tissue
    Fatma Y Meligy
    Division of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    In Vitro Cell Dev Biol Anim 48:203-15. 2012
    ..AD-MSCs showed the highest proliferation rate while BM-MSCs had the lowest one. In ICC, isolated MSCs had strong CD90- and CD44-positive expression and negative expression of CD45, CD31, and CD34, while AZA-treated MSCs had strong ..
  92. doi STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF
    Dmitri V Pechkovsky
    UBC James Hogg Research Centre, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Pathol 180:1398-412. 2012
    ..and activation, including expression of α-smooth muscle actin (α-SMA), collagen, and adhesion molecules Thy-1/CD90 and α(v) β(3) and β(5) integrins...
  93. pmc Characterization of mesenchymal progenitor cells isolated from human bone marrow by negative selection
    Ulrike I Mödder
    Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Bone 50:804-10. 2012
    ..have been used to identify marrow mesenchymal populations (alkaline phosphatase [AP], Stro-1, CD29, CD49a, CD73, CD90, CD105, CD166, CD44, CD146 and CD271) may be expressed on distinct subsets of marrow mesenchymal cells...
  94. pmc Stromal vascular progenitors in adult human adipose tissue
    Ludovic Zimmerlin
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Cytometry A 77:22-30. 2010
    ..These markers were used in multiparameter flow cytometry in conjunction with stem/progenitor markers (CD90 and CD117) to further characterize stromal vascular fraction (SVF) subpopulations...
  95. ncbi [Suppressive effects of GTW treatment on infiltration of inflammatory cell in glomeruli in anti-Thy1.1 glomerulonephritis]
    Yigang Wan
    The Department of Traditional Chinese Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
    Zhongguo Zhong Yao Za Zhi 34:72-7. 2009
    ..To examine inhibition action of multi-glycoside of Tripterygium wilfordii (GTW) on infiltration of inflammatory cell in glomeruli with anti-Thy1.1 glomerulonephritis (anti-Thy1.1 GN), and to clarify its effects on inflammatory in vitro...
  96. pmc CD90 Expression on human primary cells and elimination of contaminating fibroblasts from cell cultures
    Lynn Kisselbach
    Department of Cell Therapy, Lonza Walkersville, Inc, Walkersville, MD, 21793, USA
    Cytotechnology 59:31-44. 2009
    Cluster Differentiation 90 (CD90) is a cell surface glycoprotein originally identified on mouse thymocytes...
  97. pmc Efficient expression of self-complementary AAV in ganglion cells of the ex vivo primate retina
    Rajeshwari D Koilkonda
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, USA
    Mol Vis 15:2796-802. 2009
    ..To evaluate the efficiency of self-complementary adeno-associated virus (scAAV)-mediated gene expression of green fluorescent protein (GFP) or the allotopic human ND4 subunit of complex I in ganglion cells of the primate retina...
  98. doi Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice
    H Schell
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Muller Strasse 27, Tubingen, Germany
    Neuroscience 160:796-804. 2009
    ....
  99. doi Expression of extracellular matrix genes during myocardial recovery from heart failure after left ventricular assist device support
    Leanne E Felkin
    Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield, Middlesex, UK
    J Heart Lung Transplant 28:117-22. 2009
    ....
  100. ncbi Induction of TGF-beta1 by the matricellular protein SPARC in a rat model of glomerulonephritis
    J A Bassuk
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195 7420, USA
    Kidney Int 57:117-28. 2000
    ..Induction of TGF-beta1 by the matricellular protein SPARC in a rat model of glomerulonephritis...

Research Grants79

  1. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2003
    ....
  2. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..hypotheses, three specific aims are proposed: 1) Selection of epidermal SSCs by high expression of 06 integrin, CD90, low expression of receptors for EGF and transferrin (CD71), and preservation of the SSC phenotype by low amounts ..
  3. Investigating Cell Specific Roles of the Complement Cascade in Glaucoma
    Gareth R Howell; Fiscal Year: 2013
    ..Determining the significance of complement biosynthesis by each cell type is important for designing therapeutic interventions that manipulate the complement system. ..
  4. Astrocytic Ca2+ Signaling in the Ischemic Penumbra
    Maiken Nedergaard; Fiscal Year: 2011
    ..2006). Few approaches exist that selectively target astrocytes. Use of BAPTA and caged Ca2+ can add important PHS 398/2590 (Rev. 09/04) Page 72~ Continuation Format Page ..
  5. Environmental obesogens reduce Thy1 expression and promote obesity
    Richard P Phipps; Fiscal Year: 2013
    ..Our work focuses on the surface glycoprotein, Thy1 (CD90)...
  6. The Gut Microbiome in Neurodegenerative Disease
    Sarkis K Mazmanian; Fiscal Year: 2013
    ..If successful, the key contribution of this project will be the transformative conceptual leap that PD may have a gut microbial origin, resulting in informed advances toward probiotic therapies for neurodegeneration. ..
  7. Non-viral gene therapy for sickle cell anemia
    CLIFFORD JOHN STEER; Fiscal Year: 2010
    ..The ultimate goal of this research project is to develop and evaluate in patients an innovative gene therapy approach that has the potential to treat and correct SCA. ..
  8. Non-viral gene therapy for sickle cell anemia
    Robert Hebbel; Fiscal Year: 2009
    ..The ultimate goal of this research project is to develop and evaluate in patients an innovative gene therapy approach that has the potential to treat and correct SCA. ..
  9. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2007
    ..hypotheses, three specific aims are proposed: 1) Selection of epidermal SSCs by high expression of 06 integrin, CD90, low expression of receptors for EGF and transferrin (CD71), and preservation of the SSC phenotype by low amounts ..
  10. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..hypotheses, three specific aims are proposed: 1) Selection of epidermal SSCs by high expression of 06 integrin, CD90, low expression of receptors for EGF and transferrin (CD71), and preservation of the SSC phenotype by low amounts ..
  11. NOVEL APPROACHES TO RADIO-IMMUNOCONJUGATE DOSIMETRY
    Lee Chin; Fiscal Year: 1990
    ..The dosimetric tools developed here will be appropriate for later application to clinical radio-immunotherapy...
  12. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard Phipps; Fiscal Year: 2007
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  13. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard Phipps; Fiscal Year: 2009
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  14. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard Phipps; Fiscal Year: 2009
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  15. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard Phipps; Fiscal Year: 2006
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  16. Bcl-2 induced protection in severe sepsis
    Robert Winn; Fiscal Year: 2003
    ..to the peritoneum can provide protection from CLP when previously stimulated with antibodies to either CD3 or CD90. Thus our second hypothesis states that stimulation of T-lymphocytes with antibodies to either CD3 or CD90 results ..
  17. The Early Detection Research Network: Biomarker Developmental Laboratories
    Alvin Y Liu; Fiscal Year: 2010
    ..One example is the ~29 kDa CD90/THY1 protein found released into tumor tissue preparations...
  18. The Early Detection Research Network: Biomarker Developmental Laboratories
    Alvin Y Liu; Fiscal Year: 2013
    ..One example is the ~29 kDa CD90/THY1 protein found released into tumor tissue preparations...
  19. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2010
    ..Cluster analysis should provide insight as to whether there are interneuron cell types that are more structurally plastic than others, and whether subsets of interneurons exhibit structural plasticity correlated with OD plasticity. ..
  20. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2009
    ..Cluster analysis should provide insight as to whether there are interneuron cell types that are more structurally plastic than others, and whether subsets of interneurons exhibit structural plasticity correlated with OD plasticity. ..
  21. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2011
    ..Cluster analysis should provide insight as to whether there are interneuron cell types that are more structurally plastic than others, and whether subsets of interneurons exhibit structural plasticity correlated with OD plasticity. ..
  22. NERVE ALLOTRANSPLANTATION FOR TRAUMATIC NERVE INJURY
    Susan E Mackinnon; Fiscal Year: 2010
    ..In aim 3c this same construct is evaluated in a long swine allograft model that closely resembles the long nerve defects encountered clinically and will allow translation to the nerve-injured patient. ..
  23. NERVE ALLOTRANSPLANTATION FOR TRAUMATIC NERVE INJURY
    Susan Mackinnon; Fiscal Year: 2009
    ..In aim 3c this same construct is evaluated in a long swine allograft model that closely resembles the long nerve defects encountered clinically and will allow translation to the nerve-injured patient. ..
  24. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard P Phipps; Fiscal Year: 2010
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  25. NERVE ALLOTRANSPLANTATION FOR TRAUMATIC NERVE INJURY
    Susan Mackinnon; Fiscal Year: 2009
    ..In aim 3c this same construct is evaluated in a long swine allograft model that closely resembles the long nerve defects encountered clinically and will allow translation to the nerve-injured patient. ..
  26. Rhythmic Stimulation as a Therapeutic Option for Injured Retinal Ganglion Cells
    Gustavo C Munguba; Fiscal Year: 2012
    ..Here we propose to investigate in vivo rhythmic stimulation of injured adult RGCs as a novel therapeutic option to support retinal ganglion survival in glaucoma. ..
  27. Isolation of novel mesenchymal stem cell subpopulations
    Buddhadeb Dawn; Fiscal Year: 2009
    ..MSCs and MSC subpopulations isolated by flow cytometry based on the expression of CD45, c-kit, Flk-1, Sca-1, CD90, and CD105...
  28. Regulation and function of innate lymphoid cells in the gut
    David Artis; Fiscal Year: 2013
    ..IL-23-dependent IL-22 in Citrobacter-infected mice was a population of ROR3t-positive ILCs that expressed c-kit and CD90, and in vivo depletion of ILCs in Citrobacter-infected Rag-/- mice was associated with a defect in protective ..
  29. NERVE ALLOTRANSPLANTATION FOR TRAUMATIC NERVE INJURY
    Susan Mackinnon; Fiscal Year: 2007
    ..In aim 3c this same construct is evaluated in a long swine allograft model that closely resembles the long nerve defects encountered clinically and will allow translation to the nerve-injured patient. ..
  30. Aryl Hydrocarbon Receptor Ligands and Thyroid Eye Disease
    Richard P Phipps; Fiscal Year: 2013
    ....
  31. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert E Marc; Fiscal Year: 2013
    ..Remodeling in the human retina is more aggressive and complex than the mouse retina, with severe network revision in cone decimating zones and extreme bipolar cell rewiring and reprogramming in cone sparing zones of RP. ..
  32. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2005
    ..abstract_text> ..
  33. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2003
    ..abstract_text> ..
  34. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2005
    ..abstract_text> ..
  35. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2002
    ..abstract_text> ..
  36. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2004
    ..abstract_text> ..
  37. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 1999
    ....
  38. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2001
    ....
  39. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2002
    ....
  40. PROTHYMOCYTES AND DIABETES MELLITUS IN BB/W RATS
    Dale Greiner; Fiscal Year: 2000
    ....
  41. DIFFERENTIAL EFFECT OF CYCLOSPORINE ON LYMPHOCYTE SUBSET
    ZUHAIR BALLAS; Fiscal Year: 1992
    ..This proposal is expected to yield fruitful results clinically applicable in the autoimmunity and transplantation areas...
  42. CD4 Regulator T Cells Suppress Alloreactivity after BMT
    Bryon Johnson; Fiscal Year: 2004
    ..The information obtained will contribute significantly to our understanding of the role of regulatory T cells in mediating dominant peripheral tolerance after allo-BMT and could lead to translational applications in clinical BMT. ..
  43. CD4 Regulator T Cells Suppress Alloreactivity after BMT
    Bryon Johnson; Fiscal Year: 2001
    ..The information obtained will contribute significantly to our understanding of the role of regulatory T cells in mediating dominant peripheral tolerance after allo-BMT and could lead to translational applications in clinical BMT. ..
  44. CD4 Regulator T Cells Suppress Alloreactivity after BMT
    Bryon Johnson; Fiscal Year: 2003
    ..The information obtained will contribute significantly to our understanding of the role of regulatory T cells in mediating dominant peripheral tolerance after allo-BMT and could lead to translational applications in clinical BMT. ..
  45. CD4 Regulator T Cells Suppress Alloreactivity after BMT
    Bryon Johnson; Fiscal Year: 2002
    ..The information obtained will contribute significantly to our understanding of the role of regulatory T cells in mediating dominant peripheral tolerance after allo-BMT and could lead to translational applications in clinical BMT. ..
  46. CD4 Regulator T Cells Suppress Alloreactivity after BMT
    Bryon Johnson; Fiscal Year: 2005
    ..The information obtained will contribute significantly to our understanding of the role of regulatory T cells in mediating dominant peripheral tolerance after allo-BMT and could lead to translational applications in clinical BMT. ..
  47. Gene Therapy Reduction of Radiotherapy Esophagitis
    Joel Greenberger; Fiscal Year: 2002
    ..These studies should identify the critical cells involved in irradiation esophagitis, define the mechanism of irradiation killing and potential for protection by antioxidant transgene therapy. ..
  48. Gene Therapy Reduction of Radiotherapy Esophagitis
    Joel Greenberger; Fiscal Year: 2001
    ..These studies should identify the critical cells involved in irradiation esophagitis, define the mechanism of irradiation killing and potential for protection by antioxidant transgene therapy. ..
  49. Gene Therapy Reduction of Radiotherapy Esophagitis
    Joel Greenberger; Fiscal Year: 2003
    ..These studies should identify the critical cells involved in irradiation esophagitis, define the mechanism of irradiation killing and potential for protection by antioxidant transgene therapy. ..
  50. Gene Therapy Reduction of Radiotherapy Esophagitis
    Joel Greenberger; Fiscal Year: 2005
    ..These studies should identify the critical cells involved in irradiation esophagitis, define the mechanism of irradiation killing and potential for protection by antioxidant transgene therapy. ..
  51. Gene Therapy Reduction of Radiotherapy Esophagitis
    Joel Greenberger; Fiscal Year: 2004
    ..These studies should identify the critical cells involved in irradiation esophagitis, define the mechanism of irradiation killing and potential for protection by antioxidant transgene therapy. ..
  52. ANALYSIS OF CD8 T CELL RESPONSES TO TUMORS
    Richard Dutton; Fiscal Year: 2001
    ..We will determine what controls the growth in mice with low initial tumor load and will test the hypothesis that either CD4 or CD8 populations have a role in the control of the tumor cells. ..
  53. ANALYSIS OF CD8 T CELL RESPONSES TO TUMORS
    Richard Dutton; Fiscal Year: 2003
    ..We will determine what controls the growth in mice with low initial tumor load and will test the hypothesis that either CD4 or CD8 populations have a role in the control of the tumor cells. ..
  54. ANALYSIS OF CD8 T CELL RESPONSES TO TUMORS
    Richard Dutton; Fiscal Year: 2000
    ..We will determine what controls the growth in mice with low initial tumor load and will test the hypothesis that either CD4 or CD8 populations have a role in the control of the tumor cells. ..
  55. ANALYSIS OF CD8 T CELL RESPONSES TO TUMORS
    Richard Dutton; Fiscal Year: 2002
    ..We will determine what controls the growth in mice with low initial tumor load and will test the hypothesis that either CD4 or CD8 populations have a role in the control of the tumor cells. ..
  56. FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
    Terry Smith; Fiscal Year: 2002
    ..We believe that the results of the proposed studies will lead to important insights concerning the pathogenesis of TAO and potentially define therapeutic targets for interrupting this disease. ..
  57. FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
    Terry Smith; Fiscal Year: 2003
    ..We believe that the results of the proposed studies will lead to important insights concerning the pathogenesis of TAO and potentially define therapeutic targets for interrupting this disease. ..
  58. FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
    Terry Smith; Fiscal Year: 2006
    ..We believe that the results of the proposed studies will lead to important insights concerning the pathogenesis of TAO and potentially define therapeutic targets for interrupting this disease. ..
  59. FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
    Terry Smith; Fiscal Year: 2004
    ..We believe that the results of the proposed studies will lead to important insights concerning the pathogenesis of TAO and potentially define therapeutic targets for interrupting this disease. ..
  60. FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
    Terry Smith; Fiscal Year: 2005
    ..We believe that the results of the proposed studies will lead to important insights concerning the pathogenesis of TAO and potentially define therapeutic targets for interrupting this disease. ..
  61. CORE--STEM CELL
    Malcolm Moore; Fiscal Year: 2000
    ..In vitro generated human B cells equivalent to the tonsillar naive B cell population will be generated by in vitro culture of cord blood CD34+ cells. ..
  62. Rhythmic Stimulation as a Therapeutic Option for Injured Retinal Ganglion Cells
    Gustavo C Munguba; Fiscal Year: 2013
    ..The goal of this proposal is to explore a clinically applicable treatment modality to aid adult RGC neuron survival and axon regeneration after injury. ..
  63. INITIATOR T CELLS IN DELAYED-TYPE HYPERSENSITIVITY
    Philip Askenase; Fiscal Year: 1990
    ..Thus our studies on the cellular and molecular aspects of DTH initiation have broad immunological relevance...
  64. Alzheimer Mouse Model for Intraneuronal Amyloid-Beta Oligomer Biology
    Samuel Gandy; Fiscal Year: 2009
    ....
  65. Role of interlukin 23 and innate lymphoid cells in protective immunity
    Mohamed Oukka; Fiscal Year: 2013
    ..Understanding how these pathogenic bacteria induce inflammation and host response is critical to understanding how protective immune response can promote the clearance of enteric pathogens. ..
  66. PROTECTION FROM VIRAL GASTROENTERITIS BY INTESTINAL CTLS
    Paul Offit; Fiscal Year: 1992
    ..Adaptation of murine rotaviruses to growth in tissue culture allows for an accurate determination of the virus dose used for in vitro and in vivo studies...
  67. PROTECTION FROM VIRAL GASTROENTERITIS BY INTESTINAL CTLS
    Paul Offit; Fiscal Year: 1993
    ..Adaptation of murine rotaviruses to growth in tissue culture allows for an accurate determination of the virus dose used for in vitro and in vivo studies...
  68. PROTECTION FROM VIRAL GASTROENTERITIS BY INTESTINAL CTLS
    Paul Offit; Fiscal Year: 1991
    ..Adaptation of murine rotaviruses to growth in tissue culture allows for an accurate determination of the virus dose used for in vitro and in vivo studies...
  69. MECHANISMS OF IL7-INDUCED PRE-T CELL GENE EXPRESSION
    PIERETTE APPASAMY; Fiscal Year: 1992
    ..The importance of IL7 in pre-T cell development in the fetus will be evaluated by assessing the previously mentioned endpoints following in utero injection of anti-IL7 antibodies or fetal thymus organ culture with anti- IL7 antibodies...
  70. PROTECTION FROM VIRAL GASTROENTERITIS BY INTESTINAL CTLS
    Paul Offit; Fiscal Year: 1990
    ..Adaptation of murine rotaviruses to growth in tissue culture allows for an accurate determination of the virus dose used for in vitro and in vivo studies...
  71. BRAIN IRON REGULATION: HUMAN AUTOPSIES & ANIMAL STUDIES
    James Connor; Fiscal Year: 2004
    ..abstract_text> ..
  72. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    Clifford J Woolf; Fiscal Year: 2010
    ....
  73. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    CLIFFORD WOOLF; Fiscal Year: 2009
    ....
  74. INNATE AN ADAPTIVE IMMUNITY TO MICROBIAL FLAGELLINS IN IBD
    CHARLES ELSON; Fiscal Year: 2005
    ..Innate and adaptive response of Crohn's patients to these antigens will be assessed. ..
  75. INNATE AN ADAPTIVE IMMUNITY TO MICROBIAL FLAGELLINS IN IBD
    CHARLES ELSON; Fiscal Year: 2007
    ..Innate and adaptive response of Crohn's patients to these antigens will be assessed. ..