CD9

Summary

Gene Symbol: CD9
Description: CD9 molecule
Alias: BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29, 5H9 antigen, BA-2/p24 antigen, CD9 antigen, CD9 antigen (p24), cell growth-inhibiting gene 2 protein, leukocyte antigen MIC3, motility related protein-1, tetraspanin-29
Species: human

Top Publications

  1. pmc Effects of K+ channel blockers on the action potential of hypoxic rabbit myocardium
    E Ruiz Petrich
    Department of Physiology and Biophysics, Faculty of Medicine, University of Sherbrooke, , Canada
    Br J Pharmacol 106:924-30. 1992
  2. ncbi Complexes of tetraspanins with integrins: more than meets the eye
    F Berditchevski
    CRC Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, B15 2TA, UK
    J Cell Sci 114:4143-51. 2001
  3. doi Cell surface tetraspanin CD9 mediates chemoresistance in small cell lung cancer
    Satoshi Kohmo
    Department of Respiratory Medicine, Allergy, and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Cancer Res 70:8025-35. 2010
  4. doi Tetraspanin CD9 in cell migration
    Dale Powner
    School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochem Soc Trans 39:563-7. 2011
  5. pmc Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility
    M Miyake
    Department of Thoracic Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
    J Exp Med 174:1347-54. 1991
  6. pmc Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA
    S Ikeyama
    Department VI, Takeda Chemical Industries, Ltd, Osaka, Japan
    J Exp Med 177:1231-7. 1993
  7. doi Lateral organization of membrane proteins: tetraspanins spin their web
    Stephanie Charrin
    INSERM, U, Villejuif, France
    Biochem J 420:133-54. 2009
  8. ncbi Reduced motility related protein-1 (MRP-1/CD9) gene expression as a factor of poor prognosis in non-small cell lung cancer
    M Higashiyama
    Department of Surgery, Center for Adult Diseases of Osaka, Japan
    Cancer Res 55:6040-4. 1995
  9. pmc Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking
    Oleg V Kovalenko
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Biochem J 377:407-17. 2004
  10. ncbi HIV-1 replication in dendritic cells occurs through a tetraspanin-containing compartment enriched in AP-3
    Eduardo Garcia
    Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, 1211 Geneva, Switzerland
    Traffic 9:200-14. 2008

Detail Information

Publications237 found, 100 shown here

  1. pmc Effects of K+ channel blockers on the action potential of hypoxic rabbit myocardium
    E Ruiz Petrich
    Department of Physiology and Biophysics, Faculty of Medicine, University of Sherbrooke, , Canada
    Br J Pharmacol 106:924-30. 1992
    ..and at least one yet unidentified current component rather insensitive to changes in [K]o and to K+ channel blockers...
  2. ncbi Complexes of tetraspanins with integrins: more than meets the eye
    F Berditchevski
    CRC Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, B15 2TA, UK
    J Cell Sci 114:4143-51. 2001
    ....
  3. doi Cell surface tetraspanin CD9 mediates chemoresistance in small cell lung cancer
    Satoshi Kohmo
    Department of Respiratory Medicine, Allergy, and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Cancer Res 70:8025-35. 2010
    ..We found that the tetraspanin family member CD9 was expressed preferentially in SCLC tumors and metastases from three of seven relapsed patients, whereas chemonaï..
  4. doi Tetraspanin CD9 in cell migration
    Dale Powner
    School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochem Soc Trans 39:563-7. 2011
    Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion...
  5. pmc Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility
    M Miyake
    Department of Thoracic Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
    J Exp Med 174:1347-54. 1991
    ....
  6. pmc Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA
    S Ikeyama
    Department VI, Takeda Chemical Industries, Ltd, Osaka, Japan
    J Exp Med 177:1231-7. 1993
    ..by monoclonal antibody (mAb) M31-15 inhibiting cell motility and that the sequence of MRP-1 coincides with that of CD9. In the present study, plasmid was constructed in which human MRP-1/CD9 cDNA is expressed under the control of the ..
  7. doi Lateral organization of membrane proteins: tetraspanins spin their web
    Stephanie Charrin
    INSERM, U, Villejuif, France
    Biochem J 420:133-54. 2009
    ....
  8. ncbi Reduced motility related protein-1 (MRP-1/CD9) gene expression as a factor of poor prognosis in non-small cell lung cancer
    M Higashiyama
    Department of Surgery, Center for Adult Diseases of Osaka, Japan
    Cancer Res 55:6040-4. 1995
    Motility related protein-1 (MRP-1) is a transmembrane glycoprotein that is identical to the CD9 antigen. In previous studies, we showed that various types of cultured tumor cells transfected with MRP-1/CD9 cDNA have low motility and ..
  9. pmc Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking
    Oleg V Kovalenko
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Biochem J 377:407-17. 2004
    ..Evidence for constitutive CD9 homodimers was obtained using several cell lines, utilizing the following four methods: (1) spontaneous cross-..
  10. ncbi HIV-1 replication in dendritic cells occurs through a tetraspanin-containing compartment enriched in AP-3
    Eduardo Garcia
    Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, 1211 Geneva, Switzerland
    Traffic 9:200-14. 2008
    ..stomatitis virus protein G colocalized in a viral compartment enriched in tetraspanins including CD81, CD82 and CD9, although at different levels, indicating a role of the viral envelope in targeting to the tetraspanin-rich ..
  11. ncbi Role of tetraspanins CD9 and CD151 in primary melanocyte motility
    M Angeles Garcia-Lopez
    Department of Dermatology, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    J Invest Dermatol 125:1001-9. 2005
    Tetraspanins CD9 and CD151 have been implicated in cellular motility and intercellular adhesion in several cellular types...
  12. ncbi CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma
    K J Radford
    Oncology and Immunology Unit, David Maddison Clinical Sciences Building, Newcastle, New South Wales, Australia
    Biochem Biophys Res Commun 222:13-8. 1996
    ..These results are the first to demonstrate an association between CD63 and two other TM4SF members, CD9 and CD81 in 2 human melanoma cell lines...
  13. ncbi A specific microdomain ("glycosynapse 3") controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9
    Koji Mitsuzuka
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 280:35545-53. 2005
    ..is highly dependent on the organization and function of microdomains composed of integrin, proteolipid/tetraspanin CD9, and ganglioside (Ono, M., Handa, K., Sonnino, S., Withers, D. A., Nagai, H., and Hakomori, S...
  14. ncbi CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)
    K R Park
    Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Hum Reprod 6:252-7. 2000
    Recently we reported that CD9 is involved in the invasion of a trophoblast-like choriocarcinoma cell line, BeWo, probably through the regulation of integrin functions...
  15. ncbi Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin
    P M Sincock
    Department of Medicine, The University of Adelaide, Australia
    J Histochem Cytochem 45:515-25. 1997
    It has recently been shown that several members of the tetraspan superfamily, including CD9 and CD63, associate with each other and with beta1 integrins...
  16. pmc CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophages
    Ezequiel Ruiz-Mateos
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Virol 82:4751-61. 2008
    ..into intracellularly sequestered plasma membrane domains that contain several other tetraspanins, including CD81, CD9, and CD53. CD63 is recruited to this domain following HIV infection...
  17. pmc Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells
    Jia Weng
    Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
    J Virol 83:7467-74. 2009
    ..Overall, these data establish tetraspanins as negative regulators of HIV-1-induced cell-cell fusion, and they start delineating the requirements for this regulation...
  18. pmc Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins
    Kei Sato
    Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara cho, Sakyo ku, Kyoto, Kyoto 606 8507, Japan
    J Virol 82:1021-33. 2008
    ..In addition, these behaviors were commonly observed in other tetraspanin proteins, such as CD9, CD81, CD82, and CD231...
  19. pmc Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domains
    Clare Jolly
    The Sir William Dunn School of Pathology, The University of Oxford, Oxford OX1 3RE, United Kingdom
    J Virol 81:7873-84. 2007
    ..glycoprotein (Env) and the core protein (Gag) colocalize strongly with CD63 and CD81 and less strongly with CD9, whereas no colocalization was seen between Env or Gag and the late endosome/lysosomal marker Lamp2...
  20. ncbi The major CD9 and CD81 molecular partner. Identification and characterization of the complexes
    S Charrin
    INSERM U268, Hopital Paul Brousse, 94807 Villejuif Cedex, France
    J Biol Chem 276:14329-37. 2001
    ..We have previously identified a 135-kDa molecule (CD9P-1) as a major molecular partner of CD9 in cancer cell lines...
  21. ncbi Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins
    X A Zhang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 276:25005-13. 2001
    ..plasma membrane leads to their specific association with transmembrane-4 superfamily (TM4SF; tetraspanin) proteins (CD9, CD53, CD81, CD82, and CD151), as demonstrated by reciprocal co-immunoprecipitation and covalent cross-linking ..
  22. ncbi EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily
    C S Stipp
    Dana Farber Cancer Institute and the Department of Pathology, Harvard Medical School, Boston, Mssachusetts 02115, USA
    J Biol Chem 276:40545-54. 2001
    ..EWI-2 associated specifically with CD9 and CD81 but not with other tetraspanins or with integrins...
  23. ncbi Down-regulation of CD9 expression during prostate carcinoma progression is associated with CD9 mRNA modifications
    Jia Chi Wang
    McMaster University Medical Centre, Hamilton, Ontario, Canada
    Clin Cancer Res 13:2354-61. 2007
    Cluster-of-differentiation antigen 9 (CD9) protein, a member of the tetraspanin family, has been implicated in carcinogenesis of various human tumors...
  24. ncbi Tetraspanins CD9 and CD81 modulate HIV-1-induced membrane fusion
    Mónica Gordón-Alonso
    Servicio de Inmunologia, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    J Immunol 177:5129-37. 2006
    ..Therefore, the role of CD81 and other related tetraspanin, CD9, on the cell-to-cell fusion process mediated by HIV-1 was studied...
  25. ncbi Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation
    Stephanie Charrin
    INSERM U268, Hopital Paul Brousse, 94807 Cedex, Villejuif, France
    FEBS Lett 516:139-44. 2002
    ..All tetraspanins studied, CD9, CD37, CD53, CD63, CD81, CD82 and CD151, were found to incorporate [3H]palmitate...
  26. pmc Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1
    Sascha Nydegger
    Graduate Program in Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
    J Cell Biol 173:795-807. 2006
    ..Here, we reveal the presence of tetraspanin-enriched microdomains (TEMs) containing the tetraspanins CD9, CD63, CD81, and CD82 at the plasma membrane...
  27. pmc Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions
    V Serru
    INSERM U268, Hopital Paul Brousse, 94807 Villejuif Cedex, France
    Biochem J 340:103-11. 1999
    ..mild detergent, digitonin, dissociated most of these associated molecules, including integrins, from the tetraspans CD9, CD37, CD53, CD63, CD82, Co-029, Talla-1 and NAG-2...
  28. ncbi FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein
    C S Stipp
    Dana Farber Cancer Institute and the Department of Pathology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 276:4853-62. 2001
    CD81 and CD9, members of the transmembrane-4 superfamily (TM4SF; tetraspanins), form extensive complexes with other TM4SF proteins, integrins, and other proteins, especially in mild detergents...
  29. ncbi Immunohistochemically detected expression of motility-related protein-1 (MRP-1/CD9) in lung adenocarcinoma and its relation to prognosis
    M Higashiyama
    Department of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinariku, Japan
    Int J Cancer 74:205-11. 1997
    Motility-related protein-1 (MRP-1)/CD9 is a trans-membrane glycoprotein closely associated with suppression of cell motility and reduced metastatic potential of some tumor cells...
  30. pmc Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity
    R Iwamoto
    Institute of Life Science, Kurume University, Fukuoka, Japan
    EMBO J 13:2322-30. 1994
    DRAP27, the monkey homolog of human CD9 antigen (DRAP27/CD9) and diphtheria toxin receptor (DTR) were expressed in mouse L cells...
  31. ncbi CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82
    G Horvath
    INSERM U268, Hopital Paul Brousse, 94807 Villejuif Cedex, France
    J Biol Chem 273:30537-43. 1998
    ..4 transmembrane domains, member of the tetraspan superfamily, is engaged, together with other tetraspans such as CD9, CD53, CD63, and CD82, in multimolecular complexes containing beta1 integrins and major histocompatibility complex ..
  32. ncbi CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans
    S Lozahic
    INSERM U268, Hopital Paul Brousse, Villejuif, France
    Eur J Immunol 30:900-7. 2000
    ..raised and selected monoclonal antibodies (mAb) for their ability to immunoprecipitate a molecule associated with CD9. A unique mAb was identified which recognizes the complement regulator CD46 (membrane cofactor protein)...
  33. pmc Latent transforming growth factor beta-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor
    Joanna S Brooke
    Dept of Biological Science, DePaul University, Chicago, IL 60614, USA
    BMC Cell Biol 3:2. 2002
    ..cDNA clones containing nucleotide sequences encoding domains of two proteins were obtained and their derived amino acid sequences were evaluated...
  34. ncbi A functionally relevant conformational epitope on the CD9 tetraspanin depends on the association with activated beta1 integrin
    Maria Dolores Gutierrez-Lopez
    Instituto de Farmacologia y Toxicologia CSIC UCM, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    J Biol Chem 278:208-18. 2003
    ..The tetraspanin CD9 has been implicated in cell motility, metastasis, and sperm-egg fusion...
  35. ncbi Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63
    V Horejsi
    Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague
    FEBS Lett 288:1-4. 1991
    ..of the recently described leucocyte surface (glyco)-proteins with significant amino acid sequence similarity (human CD9, CD37, CD53, CD63, TAPA-1, CO-029 and R2 and several homologues of other species) are distinguished by the ..
  36. ncbi Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion
    Keisuke Kaji
    Department of Life Science, Tokyo Institute of Technology, Yokohama, 226 8501, Japan
    Dev Biol 247:327-34. 2002
    b>CD9 is a membrane protein belonging to the tetraspanin family...
  37. pmc Calcium antagonist and antiperoxidant properties of some hindered phenols
    G P Sgaragli
    Istituto di Scienze Farmacologiche, Siena, Italy
    Br J Pharmacol 110:369-77. 1993
    ..8. Di-t-BHA is proposed as a lead reference compound for future synthesis of new antioxidants combining two potentially useful properties in the prevention of tissue damage after ischaemia reperfusion injury...
  38. pmc Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes
    L Folgueira
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 70:223-31. 1996
    ..Altogether, these results suggest that atypical PKC isoenzymes, including PKC-zeta, participate in the signal transduction pathways by which HIV infection results in the activation of NF-kappa B in human monocytic cells and macrophages...
  39. pmc Muscarinic (M1) receptor-mediated inhibition of K(+)-evoked [3H]-noradrenaline release from human neuroblastoma (SH-SY5Y) cells via inhibition of L- and N-type Ca2+ channels
    R L McDonald
    Department of Pharmacology, University of Leeds
    Br J Pharmacol 113:621-7. 1994
    ..Keywords: SH-SY5Y; calcium channels; noradrenaline release; muscarinic receptor; nifedipine; w-conotoxin GVIA; pirenzepine;hexahydrosiladiphenidol..
  40. pmc Blockade by ifenprodil of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones: comparison with N-methyl-D-aspartate receptor antagonist actions
    J Church
    Department of Anatomy, University of British Columbia, Vancouver, Canada
    Br J Pharmacol 113:499-507. 1994
    ..Keywords: Ifenprodil; voltage-activated calcium channels; N-methyl-D-aspartate (NMDA); polyamines; cultured hippocampal pyramidal neurones..
  41. pmc Evidence for an external location of the dihydropyridine agonist receptor site on smooth muscle and skeletal muscle calcium channels
    C Strübing
    Institut fur Biochemische Pharmakologie, Innsbruck, Austria
    Br J Pharmacol 108:884-91. 1993
    ..The DHP binding domain can be reached by agonists and antagonists from the extracellular but not from the intracellular face of the membrane...
  42. pmc Modulation of calcium channel currents by arachidonic acid in single smooth muscle cells from vas deferens of the guinea-pig
    N Nagano
    Department of Chemical Pharmacology, Faculty of Pharmacentical Science, Nagoya City University, Japan
    Br J Pharmacol 116:1887-93. 1995
    ..The inhibition of Ca channel current by AA may be partly induced by superoxide radicals derived from AA oxidation. PGF2A also reduces Ca channel currents but probably by a separate mechanism via activation of a GTP binding protein...
  43. ncbi Homing of the myeloma cell clone
    K Vanderkerken
    Department of Hematology-Immunology, Free University Brussels, Belgium
    Acta Oncol 39:771-6. 2000
    ..analysis we demonstrated that the stroma-dependent MM5 cells show a downregulation of the motility-related protein (MRP-I CD9) which might reflect the involvement of this molecule in the regulation of myeloma cell extravasation.
  44. pmc The effect of supplemental beta-carotene on immunologic indices in patients with AIDS: a pilot study
    D A Fryburg
    Division of Endocrinology and Metabolism, Yale University School of Medicine, New Haven, Connecticut, USA
    Yale J Biol Med 68:19-23. 1995
    ..These preliminary observations suggest that short-term treatment with beta-carotene may increase CD4+ cell counts in patients with AIDS who have greater than 10 cells/microliters...
  45. pmc Raman spectroscopy of DNA-metal complexes. I. Interactions and conformational effects of the divalent cations: Mg, Ca, Sr, Ba, Mn, Co, Ni, Cu, Pd, and Cd
    J Duguid
    Department of Biochemistry, University of Minnesota, St Paul 55108
    Biophys J 65:1916-28. 1993
    ..Metal cation linkage of two displaced bases would allow separate DNA strands to crosslink. Aggregation is proposed to result from the formation of an extended network of these crosslinks...
  46. pmc Intravenous immunoglobulin in symptomatic and asymptomatic children with perinatal HIV infection
    L Olopoenia
    Department of Pediatrics, DC General Hospital, Washington, DC 20012, USA
    J Natl Med Assoc 89:543-7. 1997
    ..However, symptomatic patients responded much better than the asymptomatic patients...
  47. pmc Evaluation of surface tension and ion occupancy effects on gramicidin A channel lifetime
    A Ring
    Department of Physiology and Medical Biophysics, Uppsala University, Sweden
    Biophys J 53:541-8. 1988
    ..These effects of blockers, osmotic agents, and voltage on the lifetime, as well as the lack of effect of voltage at low salt levels, are consistent with the occupancy hypothesis...
  48. ncbi [Strip immunoblot assay (SIA) with recombinant antigens and synthetic peptide for detection of anti HIV-1 and HIV-2 antibodies]
    M Deguchi
    Laboratory for Clinical Investigatio, Osaka University Hospital
    Kansenshogaku Zasshi 75:371-81. 2001
    ..The SIA method indicated the positive readings earlier than the WB1 assay. The present findings indicated that the SIA method was more specific and sensitive than the WB assay, and would be useful as a confirmatory test...
  49. pmc Investigations into neuropeptide Y-mediated presynaptic inhibition in cultured hippocampal neurones of the rat
    D Bleakman
    Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637
    Br J Pharmacol 107:334-40. 1992
    ..These results are consistent with a localized presynaptic inhibitory effect of NPY on glutamate release in hippocampal neurones in culture...
  50. pmc Strychnine-induced potassium current in CA1 pyramidal neurones of the rat hippocampus
    S Ebihara
    Department of Neurophysiology, Tohoku University School of Medicine, Sendai, Japan
    Br J Pharmacol 106:823-7. 1992
    ..7. When neurones were loaded with cholera toxin (CTX) or pertussis toxin (PTX) through a patch pipette, PTX suppressed the Str response whereas CTX did not, suggesting that G, and/or Go might be involved in the Str-induced IK...
  51. pmc Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members
    J Fullekrug
    Cell Biology and Cell Biophysics Program, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Mol Biol Cell 10:1939-55. 1999
    ....
  52. pmc Kinin-induced chloride permeability changes in colony 29 epithelia estimated from 125I- efflux and MEQ fluorescence
    L J MacVinish
    Department of Pharmacology, University of Cambridge
    Br J Pharmacol 108:469-78. 1993
    ..7. It is concluded that LBK increases electrogenic chloride secretion in Colony 29 epithelia through the generation of second messengers cyclic AMP and Ca2+, each of which may act on both apical and basolateral membranes...
  53. ncbi K+ current stimulation by Cl- in the midgut epithelium of tobacco hornworm (Manduca sexta). II. Analysis of Ba(2+)-induced K+ channel conduction noise
    W Zeiske
    , , FRG
    J Comp Physiol B 162:340-4. 1992
    ..It seems likely that basolateral K+ channels (1) are subject to anionic gating ligands, and (2) depend on anions with respect to the rate of K+ transfer through an open K+ channel...
  54. ncbi The ambulatory care of HIV-infected persons: a survey of physician practice patterns
    M D Stein
    Division of General Internal Medicine, Rhode Island Hospital, Providence 02903
    J Gen Intern Med 7:180-6. 1992
    ..Such incorporation might increase guideline acceptance by practicing clinicians...
  55. ncbi [A case of primary HIV-1 infection]
    H Sugiyama
    Department of Internal Medicine, Teikyo University School of Medicine
    Kansenshogaku Zasshi 71:949-52. 1997
    ..Diagnosis of primary HIV-1 infection was made. Recently, HIV-1 infection has been increasing in Japan. Consideration of this disease in differential diagnosis of acute febrile illness is necessary...
  56. ncbi Ionic currents in cardiac myocytes of squid, Alloteuthis subulata
    M P Odblom
    Marine Biological Association, Plymouth, UK
    J Comp Physiol B 170:11-20. 2000
    ..It also had a more transient time course, was activated at more negative potentials, and resembled the previously described low-voltage-activated, T-type calcium current...
  57. ncbi Detection of simian T-lymphotropic virus type I using the polymerase chain reaction
    C S Dezzutti
    Department of Veterinary Pathobiology, Ohio State University, Columbus 43210
    Int J Cancer 50:805-10. 1992
    ..Additionally, our data suggest that the tax and pol gene regions are conserved between HTLV-I and STLV-I strains found among these diverse species of non-human primates...
  58. ncbi Regulation of a voltage-dependent, calcium-activated K conductance by cyclic GMP in dissociated flounder enterocytes
    K E Cooper
    Department of Physiology and Animal Sciences, University of Minnesota, St Paul 55108
    J Comp Physiol B 163:581-6. 1993
    ..l-1 Ba2+ to cells bathed in symmetric K Ringer's solution resulted in nearly complete inhibition of outward current. Charybdotoxin produced only minor effects on this current.(ABSTRACT TRUNCATED AT 250 WORDS)..
  59. ncbi Differential in vitro anti-HIV activity of natural lignans
    H C Schroder
    Abteilung Angewandte Molekularbiologie, Universitat Mainz, Bundesrepublik Deutschland
    Z Naturforsch C 45:1215-21. 1990
    ..Our results suggest that both compounds prevent the increase of topoisomerase II activity, involved in virus replication, after infection of cells with HIV-1...
  60. ncbi Boronate affinity adsorption of RNA: possible role of conformational changes
    N Singh
    Department of Chemical Engineering, University of Houston, TX 77204-4792, USA
    J Chromatogr A 840:205-13. 1999
    ..The stoichiometric displacement parameter, Z, in Ba2+ buffer is three times the value in Mg2+ buffer, and is close to unity...
  61. pmc Adenosine-induced hyperpolarization of the membrane voltage in rat mesangial cells in primary culture
    H Pavenstadt
    Department of Medicine, Albert Ludwigs University, Freiburg, Germany
    Br J Pharmacol 113:7-12. 1994
    ..6. The data indicate that adenosine activates K+-conductance via an A2 receptor in mesangial cells; the activation of the K+-conductance, which is probably mediated by cyclic AMP led to a hyperpolarization of membrane voltage...
  62. pmc Effects of divalent cations and La3+ on contractility and ecto-ATPase activity in the guinea-pig urinary bladder
    A U Ziganshin
    Department of Anatomy, University College London
    Br J Pharmacol 114:632-9. 1995
    ..5. In conclusion, the ability of some divalent cations to inhibit ecto-ATPase activity and to potentiate or inhibit contractile responses in the guinea-pig urinary bladder appear to be independent effects...
  63. ncbi Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase
    OSMOND J D'CRUZ
    Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Biol Reprod 67:1959-74. 2002
    ....
  64. pmc The P2Z-purinoceptor of human lymphocytes: actions of nucleotide agonists and irreversible inhibition by oxidized ATP
    J S Wiley
    Haematology Department, Austin Hospital, Heidelberg, Victoria, Australia
    Br J Pharmacol 112:946-50. 1994
    ....
  65. ncbi [Prevalence of HIV infection among stable female partners of seropositive men]
    S Kimura
    Department of Infectious Diseases and Applied Immunology, University of Tokyo
    Kansenshogaku Zasshi 67:95-101. 1993
    ..01). HIV-p24 antigen was measured in 10 of 11 seropositive men. The antigen was positive in four men, and negative in six.(ABSTRACT TRUNCATED AT 250 WORDS)..
  66. ncbi A study of the interaction between the Na+, K+ pump and Na+:Ca2+ exchange in macrophages and vascular smooth muscle cells
    C Galli
    INSERM U7, , Paris, France
    Am J Hypertens 1:64S-70S. 1988
    ..2',4'-Dimethylbenzamil was also able to inhibit Na+ efflux (by 3.05 +/- 0.98 mmol (L cells X h)-1; mean +/- SEM of three experiments) suggesting the existence of Na+:Sr2+ exchange.(ABSTRACT TRUNCATED AT 250 WORDS)..
  67. pmc Surrogate markers for survival in patients with AIDS and AIDS related complex treated with zidovudine
    M A Jacobson
    Department of Medicine, University of California, San Francisco
    BMJ 302:73-8. 1991
    ....
  68. ncbi [The detection of human immunodeficiency virus type 1/2 antibody using synthetic peptides]
    P Mao
    Department of Virology, 302nd Hospital of PLA, Beijing 100039
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:72-4. 1997
    ..The reagent are stable at 37 degrees C for 4 days. The results indicated that our reagent is highly specific, sensitive and stable, it can be used for detection of HIV-1/2 infections...
  69. ncbi [Study on reverse transcriptase inhibiting antibody in plasma of HIV-1 seropositive subjects]
    T Saito
    Department of Virology, Kanagawa Prefectural Public Health Laboratories
    Kansenshogaku Zasshi 69:851-7. 1995
    ..HIV strains were isolated from these 3 cases. These results suggest that reduction of RT inhibiting antibody levels correlate well with the success of HIV isolation and with progression of clinical manifestation...
  70. ncbi Analogies and differences between omega-conotoxins MVIIC and MVIID: binding sites and functions in bovine chromaffin cells
    L Gandia
    Departamento de Farmacologia, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo, 4, E 28029 Madrid, Spain
    Pflugers Arch 435:55-64. 1997
    ....
  71. ncbi Separation of calcium channel current components in mouse chromaffin cells superfused with low- and high-barium solutions
    J M Hernandez-Guijo
    Instituto de Farmacología Teófilo Hernando y Departamento de Farmacología, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 4, E 28029 Madrid, Spain
    Pflugers Arch 436:75-82. 1998
    ....
  72. ncbi Re-evaluation of the P/Q Ca2+ channel components of Ba2+ currents in bovine chromaffin cells superfused with solutions containing low and high Ba2+ concentrations
    A Albillos
    Departamento de Farmacologia, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo, 4 E 28029 Madrid, Spain
    Pflugers Arch 432:1030-8. 1996
    ..An R-type residual current is not present in these cells...
  73. ncbi [Studies on maternal transmission of HIV-1]
    Y Tabei
    Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health
    Kansenshogaku Zasshi 69:858-63. 1995
    ..None of the HIV-1 markers, except for antibody, was detected in the samples from their children and placenta. These facts strongly suggest that there was no HIV-1 transmission from mother to child...
  74. ncbi [Study on molecular epidemiology of Borna disease virus in Zunyi regions of Guizhou province]
    Chang ming Wang
    Department of Neruology, 1st Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China
    Zhonghua Liu Xing Bing Xue Za Zhi 29:1213-6. 2008
    ..In order to study the epidemiology of Borna disease virus (BDV) in Zunyi region and its surrounding regions in Guizhou province...
  75. pmc Ionic currents and inhibitory effects of glibenclamide in seminal vesicle smooth muscle cells
    H Sadraei
    Department of Pharmacology, University of Leeds
    Br J Pharmacol 115:1447-54. 1995
    ..In addition, an unexpected relaxant effect of high concentrations of glibenclamide may be explained by inhibition of the Ca channels...
  76. ncbi Development of a monoclonal antibody-based p24 capsid antigen detection assay for HTLV-I, HTLV-II, and STLV-I infection
    G Toedter
    Coulter Immunology, Hialeah, Florida
    AIDS Res Hum Retroviruses 8:527-32. 1992
    ..Similarly, normal human peripheral blood mononuclear cells and uninfected, transformed human T cells, were also negative in the assay.(ABSTRACT TRUNCATED AT 250 WORDS)..
  77. ncbi Didanosine therapy in patients intolerant of or failing zidovudine therapy
    R C Rathbun
    Section of Pharmacy Practice, College of Pharmacy, University of Oklahoma, Oklahoma City, OK 73190
    Ann Pharmacother 26:1347-51. 1992
    ..Also, development of peripheral neuropathy may occur at lower cumulative doses in these patient populations...
  78. ncbi Measurement of HIV-1 p24 antigen by signal-amplification-boosted ELISA of heat-denatured plasma is a simple and inexpensive alternative to tests for viral RNA
    Jorg Schupbach
    Swiss National Center for Retroviruses, University of Zurich, Gloriastr 30, CH 8028 Zurich Switzerland
    AIDS Rev 4:83-92. 2002
    ..There is no problem with sample instability and no need for cumbersome nucleic acid extraction. The test is validated for subtype B, but requires further studies for non-B subtypes...
  79. ncbi Different modes of electrogenic Na+ absorption in the coprodeum of the chicken embryo: role of extracellular Ca2+
    M Heinz
    , , Federal Republic of Germany
    J Comp Physiol B 161:363-70. 1991
    ..The results indicate that Na+ absorption in the coprodeum of the chicken embryo is more complex than in adult hens.(ABSTRACT TRUNCATED AT 250 WORDS)..
  80. ncbi Separation and detection of common mono- and divalent cations by ion chromatography with an ODS column and conductivity/UV detection
    K Ito
    Department of Environmental Science, Faculty of Engineering, Hiroshima University, Japan
    J Chromatogr A 850:247-56. 1999
    ..CD detection was possible for M+ and M2+ and UV detection for M2+. (3) For M2+, the mobile phase, 0.8 mM Ce(III) + 0.1 mM SDS + 1 mM HNO3 and indirect UV detection were effective. The IC methods were applied to real samples...
  81. ncbi Sensitivity and specificity of anti-HIV ELISA employing recombinant (p24, p66, gp120) and synthetic (gp41) viral antigenic peptides
    G Filice
    Department of Infectious Diseases, University of Pavia, IRCCS Policlinico S Matteo
    Microbiologica 14:185-94. 1991
    ..b...
  82. pmc Intracellular pH transients of mammalian astrocytes
    M Chesler
    Department of Neurology, Cornell University Medical College, New York, New York 10021
    J Neurosci 9:2011-9. 1989
    ..The sensitivity of the response to Ba2+ suggests that it is triggered by membrane depolarization. These results suggest that glial pHi is normally modulated by the level of local neuronal activity...
  83. ncbi Inhibition of the P-glycoprotein- and multidrug resistance protein-mediated efflux of anthracyclines and calceinacetoxymethyl ester by PAK-104P
    C Marbeuf Gueye
    , , 74 rue Marcel Cachin, Bobigny, France
    Eur J Pharmacol 391:207-16. 2000
    ..A second mechanism involving a high-affinity site for PAK-104P and which would concern molecules such as anthracyclines, calcein acetoxymethyl ester whose efflux depends on the presence of glutathione...
  84. ncbi On the mechanisms of cholinergic control of the sinoatrial node discharge
    M Vassalle
    Department of Physiology and Pharmacology, State University of New York, Brooklyn 11203, USA
    J Cardiovasc Pharmacol 37:173-86. 2001
    ..The results with Cs+ and Ba2+ indicate that both high and low concentrations of carbachol decrease sinoatrial node discharge by activating the I(K,ACh) channels rather than by decreasing If...
  85. ncbi The effect of treatment with zidovudine with or without acyclovir on HIV p24 antigenaemia in patients with AIDS or AIDS-related complex
    C Pedersen
    Hvidovre Hospital, Copenhagen, Denmark
    AIDS 6:821-5. 1992
    ..Change in antigen level in response to antiviral therapy needs further investigation before it is used as a surrogate marker for clinical efficacy of antiviral therapy...
  86. pmc Dual and recombinant infections: an integral part of the HIV-1 epidemic in Brazil
    A Ramos
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 5:65-74. 1999
    ....
  87. ncbi Preliminary comparison of precursor scans and liquid chromatography-tandem mass spectrometry on a hybrid quadrupole time-of-flight mass spectrometer
    C Borchers
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Chromatogr A 854:119-30. 1999
    ..LC-MS-MS, therefore, appears to be better for the detection of trace components in complex mixtures...
  88. ncbi [Analysis of immunophenotype and leukemia associated immunophenotype in 610 patients with acute myeloid leukemia]
    Yan Rong Liu
    Peking University, Institute of Hematology, People s Hospital, Beijing, China
    Zhonghua Xue Ye Xue Za Zhi 28:731-6. 2007
    ..To analyze the immunophenotype and leukemia associated immunophenotype (LAIP) of leukemia cells from patients with acute myeloid leukemia (AML) in minimal residual disease (MRD) detection...
  89. ncbi Lymph node architecture preceding and following 6 months of potent antiviral therapy: follicular hyperplasia persists in parallel with p24 antigen restoration after involution and CD4 cell depletion in an AIDS patient
    J M Orenstein
    Department of Pathology, George Washington University Medical Center, Washington, DC 20037, USA
    AIDS 13:2219-29. 1999
    ..To evaluate changes in architecture, viral RNA, and viral protein over 6 months in lymph nodes from retroviral-naïve HIV-infected persons before and after commencing highly active antiretroviral therapy (HAART)...
  90. pmc Production and purification of immunologically active core protein p24 from HIV-1 fused to ricin toxin B subunit in E. coli
    Alberto J Donayre-Torres
    Centro de Investigación y de Estudios Avanzados Cinvestav, Unidad Irapuato, Km 9 6 Libramiento Norte, 36500 Carretera Irapuato León, Irapuato, Guanajuato, Mexico
    Virol J 6:17. 2009
    ..The aim of this study was to investigate the adjuvant-carrier properties of the B ricin subunit (RTB) when fused to p24...
  91. ncbi Mechanisms underlying burst generation of the pyloric muscle in the mantis shrimp, Squilla oratoria
    K Tazaki
    Biological Laboratory, Nara University of Education, Japan
    J Comp Physiol A 169:737-50. 1991
    ....
  92. ncbi Regional sublocalization of the human thyroid peroxidase gene (TPO) by tritium and fluorescence in situ hybridization to chromosome 2p25-->p24
    P S Barnett
    Department of Medicine, King's College School of Medicine and Dentistry, London, UK
    Cytogenet Cell Genet 62:188-9. 1993
    ..Based on the results of a study using both isotopic and nonisotopic in situ hybridization, we assign the gene coding for human TPO to chromosome region 2p25-->p24...
  93. ncbi Progression to AIDS in patients with lymphadenopathy or AIDS-related complex: reappraisal of risk and predictive factors
    H W Murray
    Division of Infectious Diseases, Cornell University Medical College, New York, New York
    Am J Med 86:533-8. 1989
    ....
  94. ncbi Proline residues in the HIV-1 NH2-terminal capsid domain: structure determinants for proper core assembly and subsequent steps of early replication
    T Fitzon
    Institute of Medical Microbiology, Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, D 93053, Germany
    Virology 268:294-307. 2000
    ..These results suggest that proline residues in the NH(2)-terminal capsid domain represent critical structure determinants for proper formation of functional virion cores and subsequent stages of early replication...
  95. ncbi CD9-dependent regulation of Canine distemper virus-induced cell-cell fusion segregates with the extracellular domain of the haemagglutinin
    K Singethan
    Institut fur Virologie und Immunbiologie, Versbacher Strasse 7, D 97078 Wurzburg, Germany
    J Gen Virol 87:1635-42. 2006
    Antibodies to CD9, a member of the tetraspan transmembrane-protein family, selectively inhibit Canine distemper virus (CDV)-induced cell-cell fusion...
  96. ncbi [Investigation of a new HIV-1 p24 antigen detection kit based on the enzyme-linked fluorescent immunoassay]
    T Hayashi
    Department of Virology, Kanagawa Prefectural Public Health Laboratory
    Kansenshogaku Zasshi 74:709-15. 2000
    ..The results obtained suggest that ELFA are very useful for an earlier diagnosis of HIV infection and re-test for false positive samples by other HIV diagnosis kits...
  97. doi Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation
    Mayumi Suzuki
    Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan
    J Immunol 182:6485-93. 2009
    ..In the present study, the role of tetraspanin CD9 in LPS-induced macrophage activation and lung inflammation was investigated in vitro and in vivo...
  98. ncbi Quantification of human immunodeficiency virus type 1 p24 antigen and antibody rivals human immunodeficiency virus type 1 RNA and CD4+ enumeration for prognosis. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical
    J S Read
    Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
    Pediatr Infect Dis J 19:544-51. 2000
    ....
  99. ncbi [Evaluation of an HIV screening assay kit for the combined detection of anti-HIV-1/2 antibodies and HIV p24 antigen]
    T Shima
    Department of Virology, Kanagawa Prefectural Public Health Laboratory, Yokohama City University Hospital, School of Medicine
    Kansenshogaku Zasshi 75:1014-24. 2001
    ..All of these specimens were positive by Genscreen HIV Ag-Ab. Therefore, Genscreen HIV Ag-Ab that shorten the window period is a useful and reliable for HIV screening test, especially in case of primary infection...
  100. ncbi Viral load, viral phenotype modification, zidovudine susceptibility and reverse transcriptase mutations during the first 6 months of zidovudine monotherapy in HIV-1-infected people
    S Rusconi
    Clinica delle Malattie Infettive, Universita di Milano, Ospedale Luigi Sacco, Italy
    Antivir Ther 1:211-9. 1996
    ..076). SI phenotype was associated with the development of a decreased zidovudine susceptibility. A correlation between zidovudine-associated pol gene mutations and SI phenotype was detected at the 6-month time point...
  101. ncbi Ba2+ ions evoke two kinetically distinct patterns of exocytosis in chromaffin cells, but not in neurohypophysial nerve terminals
    E P Seward
    Department of Neurobiology and Anatomy, Medical College of Pennsylvania, Philadelphia 19129, USA
    J Neurosci 16:1370-9. 1996
    ..Only a single kinetic pattern is detected in NHP terminals, suggesting that mechanisms for secretion are not universally distributed in excitable cells...

Research Grants124 found, 100 shown here

  1. Pharmacology of Antiretroviral Nanoparticle Micelles
    Christopher J Destache; Fiscal Year: 2010
    ..Due to the nanoparticle small size, the particles will stay in tissue longer and allow for less frequent dosing. This nanoparticle delivery system could affect the future of HIV- 1 treatment. ..
  2. Role of Tetraspan Glycoproteins (CD63) in HIV Replication
    MONIQUE REGAIL FERGUSON; Fiscal Year: 2010
    ..in HIV infection (MS #1), and other tetraspanins have been implicated in infection with HTLV-I (CD82), FIV (CD9) and Hepatitis C virus (CD81)...
  3. COMBINATORIAL-DESIGNED NANO-PLATFORMS TO OVERCOME TUMOR DRUG RESISTANCE
    Zhenfeng Duan; Fiscal Year: 2010
    ..and cytotoxic drugs for maximum cell-kill effect. ..
  4. COMBINATORIAL-DESIGNED NANO-PLATFORMS TO OVERCOME TUMOR DRUG RESISTANCE
    Zhenfeng Duan; Fiscal Year: 2013
    ..and cytotoxic drugs for maximum cell-kill effect. ..
  5. Role of Tetraspan Glycoproteins (CD63) in HIV Replication
    MONIQUE FERGUSON; Fiscal Year: 2009
    ..in HIV infection (MS #1), and other tetraspanins have been implicated in infection with HTLV-I (CD82), FIV (CD9) and Hepatitis C virus (CD81)...
  6. Point-of-Care HIV Antigen/Antibody Diagnostic Device
    Michael J Lochhead; Fiscal Year: 2013
    ..The outcome of this program will be a system design and dataset for an FDA investigational device exemption (IDE) meeting in advance of clinical trials. ..
  7. TARGETED CELLULAR KILLING OF HIV AND HIV-INFECTED CELLS
    MICHAEL FANGER; Fiscal Year: 1993
    ....
  8. FUNCTIONS OF PREGNANCY SPECIFIC GLYCOPROTEINS
    Gabriela S Dveksler; Fiscal Year: 2010
    ..We determined that murine Psg17 and Psg19 bind to the tetraspanin CD9 but the activity and receptor usage of the other 15 members of the murine Psg family remains to be studied...
  9. FUNCTIONS OF PREGNANCY SPECIFIC GLYCOPROTEINS
    Gabriela S Dveksler; Fiscal Year: 2010
    ..We determined that murine Psg17 and Psg19 bind to the tetraspanin CD9 but the activity and receptor usage of the other 15 members of the murine Psg family remains to be studied...
  10. Variation in platelet function: the genetics of platelet gene expression
    Paul F Bray; Fiscal Year: 2010
    ..of genes regulating the platelet response to specific agonists (ADP, CRP, collagen, TRAP, U46619, ristocetin, CD9 and epinephrine), as well as genes common to multiple platelet stimuli, and permit assessment of the effects of ..
  11. Variation in platelet function: the genetics of platelet gene expression
    Paul F Bray; Fiscal Year: 2013
    ..of genes regulating the platelet response to specific agonists (ADP, CRP, collagen, TRAP, U46619, ristocetin, CD9 and epinephrine), as well as genes common to multiple platelet stimuli, and permit assessment of the effects of ..
  12. Epididymal PMCA4 Expression Functional Impact and Mechanism of Sperm Uptake
    PATRICIA ANASTASIA DELEON; Fiscal Year: 2013
    ..of membranous vesicles or epididymosomes, in delivering PMCA4/a to the sperm surface, assisted by the presence of CD9 tetraspanin which mediates cell-to-cell protein transfer via membrane fusion...
  13. The STOP Study
    Cynthia L Gay; Fiscal Year: 2013
    ..This has momentous public health implications since individuals with AHI appear to continue to engage in the high-risk behaviors that led to recent HIV acquisition, particularly if they do not know they are infected. ..
  14. The STOP Study
    Cynthia L Gay; Fiscal Year: 2012
    ..This has momentous public health implications since individuals with AHI appear to continue to engage in the high-risk behaviors that led to recent HIV acquisition, particularly if they do not know they are infected. ..
  15. Mycoplasma pneumoniae Gliding Motility
    DUNCAN C contact KRAUSE; Fiscal Year: 2010
    ..pneumoniae in onset and recurrence of asthma. The studies proposed here will elucidate the mechanism and role of gliding motility in the colonization of the conducting airways. ..
  16. Mycoplasma pneumoniae Gliding Motility
    DUNCAN C contact KRAUSE; Fiscal Year: 2010
    ..pneumoniae in onset and recurrence of asthma. The studies proposed here will elucidate the mechanism and role of gliding motility in the colonization of the conducting airways. ..
  17. Mechanism of neurological and cognitive side effects of sevoflurane anesthesia at
    Anatoly E Martynyuk; Fiscal Year: 2013
    ....
  18. Immunomodulatory Function of Human T Cell Leukemia Virus Type 2 (HTLV-2)
    Mark A Beilke; Fiscal Year: 2011
    ..The proposed studies will focus on exploring possible strategies for immune based therapy of HIV infected patients. ..
  19. ADAMs: Key regulators of EGFR signaling
    Carl Blobel; Fiscal Year: 2009
    ..by assessing how low or high concentrations of uncleavable TGFa, or of TGFa that is clustered by the tetraspanin CD9 or by chemical inducers of dimerization, affect EGFR-signaling...
  20. The STOP Study
    MSC WESTHEIMER; Fiscal Year: 2013
    ..Early diagnosis and notification can improve health outcomes by facilitating early referral to treatment. ..
  21. Multi-Ion, Free Energy Study of Effect of Ba2+ Blockage on KcsA Ion Selectivity
    KAREN MICHELLE CALLAHAN; Fiscal Year: 2013
    ....
  22. Ultra-sensitive method for HIV p24 antigen detection
    SIMON BYSTRYAK; Fiscal Year: 2011
    ..Successful completion of these studies will be beneficial for public health, and make available all of the technology needed for a substantial business opportunity to license the technology and manufacture commercial products. ..
  23. HIV INFECTION OF HUMAN PLACENTAL CELLS
    Kathleen McGann; Fiscal Year: 1992
    ....
  24. Novel 99mTc(III) Complexes as SPECT Radiotracers for MPI
    Shuang Liu; Fiscal Year: 2013
    ....
  25. Social experience and remodeling of amygdalar circuits in rat adolescence
    Holly Moore; Fiscal Year: 2009
    ..Moreover, the findings will contribute to the development of novel strategies for preventing the psycho- and neuropathology associated with many psychiatric disorders including schizophrenia, anxiety, and substance abuse disorders. ..
  26. Social experience and remodeling of amygdalar circuits in rat adolescence
    HOLLY MARIE MOORE; Fiscal Year: 2010
    ..Moreover, the findings will contribute to the development of novel strategies for preventing the psycho- and neuropathology associated with many psychiatric disorders including schizophrenia, anxiety, and substance abuse disorders. ..
  27. BIOPHYSICAL/GENETIC PROPERTIES OF HIV1 IN HUMAN PLASMA
    George Shaw; Fiscal Year: 2007
    ..abstract_text> ..
  28. Targeting regulators of cellular gene transcription to impact HIV latency
    Douglas D Richman; Fiscal Year: 2010
    ..abstract_text> ..
  29. Modulation of Dendritic Cells against HIV-1
    Dinesh K Singh; Fiscal Year: 2010
    ..But the intracellular molecules participating in trafficking of HIV within DCs are not clear. Tetraspanins such as CD9, CD63 and CD81 colocalize with HIV-1 particles in endosomes, but their exact role in this milieu has not been fully ..
  30. Modulation of Dendritic Cells against HIV-1
    Dinesh K Singh; Fiscal Year: 2009
    ..But the intracellular molecules participating in trafficking of HIV within DCs are not clear. Tetraspanins such as CD9, CD63 and CD81 colocalize with HIV-1 particles in endosomes, but their exact role in this milieu has not been fully ..
  31. Characterization of the immunity induced by a DEC205-targeted HIV vaccine
    Marina Caskey; Fiscal Year: 2013
    ..DEC205 HIV vaccine delivers HIV proteins to DCs and induces immune responses against HIV. ..
  32. Characterization of the immunity induced by a DEC205-targeted HIV vaccine
    Marina Caskey; Fiscal Year: 2010
    ..DEC205 HIV vaccine delivers HIV proteins to DCs and induces immune responses against HIV. ..
  33. Tetraspanins in Asthma and Eosinophilic Lung Disease
    Praveen Akuthota; Fiscal Year: 2010
    ..The specific aims of the research proposed will investigate the following hypotheses: 1) the tetraspanin CD9 is associatedwith antigen-presentation machinery in human eosinophils, 2) MHC Class II Is located predominantly in ..
  34. Modulation of Dendritic Cells against HIV-1
    Dinesh K Singh; Fiscal Year: 2011
    ..But the intracellular molecules participating in trafficking of HIV within DCs are not clear. Tetraspanins such as CD9, CD63 and CD81 colocalize with HIV-1 particles in endosomes, but their exact role in this milieu has not been fully ..
  35. Modulation of Dendritic Cells against HIV-1
    Dinesh K Singh; Fiscal Year: 2010
    ..But the intracellular molecules participating in trafficking of HIV within DCs are not clear. Tetraspanins such as CD9, CD63 and CD81 colocalize with HIV-1 particles in endosomes, but their exact role in this milieu has not been fully ..
  36. Dissecting the opposing roles of alpha-3 integrin in metastasis
    Christopher S Stipp; Fiscal Year: 2013
    ..In particular, the loss of tetraspanin CD9 in tumor cells is linked to enhanced metastasis in clinical and experimental studies...
  37. NANO-CHIP HIV DETECTION IN VULNERABLE POPULATIONS
    Glen N Gaulton; Fiscal Year: 2010
    ....
  38. RATIONAL DEVELOPMENT OF NOVEL ANTI-AIDS DRUGS
    Sylvia Lee Huang; Fiscal Year: 1992
    ..If the basis of their action lies in a fundamental biochemical difference between HIV-infected cells and normal cells, this difference may be investigated and exploited in new interventions of AIDS...
  39. Preparation and Characterization of 2nd Generation HIV-1 Maturation Inhibitor Dru
    Carl Wild; Fiscal Year: 2013
    ....
  40. National AIDS Research Institute (NARI), Pune, INDIA: Clinical Trials Unit
    Arun R Risbud; Fiscal Year: 2013
    ..We feel confident that our participation in the NIH HIVAIDS clinical trial networks will compliment our national research priorities. ADMINISTRATIVE COMPONENT: ..
  41. Smart Polymer Reagents for Sensitivity and Speed-enhanced Clinical Diagnostics
    Thomas Schulte; Fiscal Year: 2013
    ..The multiplex capabilities of these reagents and the potential for removal of serum interferences will be broadly applicable to other clinically important analytes. ..
  42. PLANT ANTI-HIV AGENTS
    Kuo Hsiung Lee; Fiscal Year: 2001
    ....
  43. PLANT ANTI-HIV AGENTS
    Kuo Hsiung Lee; Fiscal Year: 2003
    ....
  44. PLANT ANTI-HIV AGENTS
    Kuo Hsiung Lee; Fiscal Year: 2000
    ....
  45. PLANT ANTI-HIV AGENTS
    Kuo Hsiung Lee; Fiscal Year: 2002
    ....
  46. HIV INFECTION OF DEVELOPING PLACENTA
    ANTON GOUSTIN; Fiscal Year: 1991
    ....
  47. C. Perfringens to Induce Anti-HIV Mucosal Immunity
    Phalguni Gupta; Fiscal Year: 2005
    ..The proposed study provides a novel strategy to induce strong mucosal immunity against HIV-1 which can lead to development of an anti-HlV-1 oral vaccine due to its safety, low production cost and easy administration. ..
  48. C. Perfringens to Induce Anti-HIV Mucosal Immunity
    Phalguni Gupta; Fiscal Year: 2006
    ..The proposed study provides a novel strategy to induce strong mucosal immunity against HIV-1 which can lead to development of an anti-HlV-1 oral vaccine due to its safety, low production cost and easy administration. ..
  49. HOST CELL INTERACTIONS BY PATHOGENIC BORRELIAE
    JOHN LEONG; Fiscal Year: 2000
    ..platelet activation activity was apparently mediated by the integrin- associated platelet signaling molecule CD9. Relapsing fever spirochetes have also been shown to bind to erythrocytes, and we speculate that attachment of ..
  50. STRATEGIES FOR INDUCTION OF MUCOSAL IMMUNITY TO HIV
    Gregory Harriman; Fiscal Year: 1992
    ..This will be evaluated by systemically reimmunizing mice which have previously been orally immunized with the same HIV immunogen and evaluating the subsequent systemic immune response (ie. serum antibody response and cytotoxicity)...
  51. Ultra-sensitive method for HIV p24 antigen detection
    SIMON BYSTRYAK; Fiscal Year: 2009
    ..Successful completion of these studies will be beneficial for public health, and make available all of the technology needed for a substantial business opportunity to license the technology and manufacture commercial products. ..
  52. MDR Gene Polymorphisms in AML
    Maria Baer; Fiscal Year: 2007
    ..The project is expected to provide important information for use in improving AML treatment stratification and outcomes. [unreadable] [unreadable] [unreadable]..
  53. DIABETES/ISLET GROWTH PROBED WITH MONOCLONAL ANTIBODIES
    George Eisenbarth; Fiscal Year: 1990
    ..g., Factor VIII, MHC class I and class II antigens), 3) islet "activation" antigens, and 4) the ability of specific monoclonal antibodies to stimulate islet cell growth...
  54. DIABETES/ISLET GROWTH PROBED WITH MONOCLONAL ANTIBODIES
    George Eisenbarth; Fiscal Year: 1991
    ..g., Factor VIII, MHC class I and class II antigens), 3) islet "activation" antigens, and 4) the ability of specific monoclonal antibodies to stimulate islet cell growth...
  55. PHOSPHOLIPASES AND INSULIN SECRETION
    Bryan Wolf; Fiscal Year: 1999
    ..In the second approach, we will determine the identity and role of the three proteins, p24, p50, and p95, that are coupled to Galphai following glucose stimulation of beta-cells. ..
  56. Oral HIV Pathogenesis and Shedding
    Scott Brodie; Fiscal Year: 2002
    ..abstract_text> ..
  57. Oral HIV Pathogenesis and Shedding
    Robert Coombs; Fiscal Year: 2005
    ..abstract_text> ..
  58. Oral HIV Pathogenesis and Shedding
    Robert Coombs; Fiscal Year: 2004
    ..abstract_text> ..
  59. GU SITES AND CONSEQUENCES OF HIV INFECTION
    JOHN KRIEGER; Fiscal Year: 1990
    ..Insights into the mehanisms of sexual transmission of HIV and the effects of HIV infection on male reproductive function may have major implications for decreasing transmission of this deadly infection...
  60. ROLE OF THE PLACENTA IN TRANSMISSION OF HIV
    William Shearer; Fiscal Year: 1991
    ..It is possible that the results of this research project will have immediate and significant impact upon our ability to make an early, possibly prenatal, diagnosis of HIV infection in infants born to HIV-infected women...
  61. Pathogenesis of Oropharyngeal HHV-8 Infection
    Andrew Johnson; Fiscal Year: 2004
    ..This award will support the pursuit of my long-term career goal, which is to become a proficient independent clinical investigator focusing on infections in the immunocompromised host. ..
  62. Pathogenesis of Oropharyngeal HHV-8 Infection
    Andrew Johnson; Fiscal Year: 2002
    ..This award will support the pursuit of my long-term career goal, which is to become a proficient independent clinical investigator focusing on infections in the immunocompromised host. ..
  63. Pathogenesis of Oropharyngeal HHV-8 Infection
    Andrew Johnson; Fiscal Year: 2003
    ..This award will support the pursuit of my long-term career goal, which is to become a proficient independent clinical investigator focusing on infections in the immunocompromised host. ..
  64. Development of Optimized siRNA Inhibition of HIV
    John Rossi; Fiscal Year: 2004
    ..The long term goal of this research is to provide potent intracellular immunity against HIV-1 in a T-cell and hematopoietic stem cell setting. ..
  65. Pathogenesis of Oropharyngeal HHV-8 Infection
    Andrew Johnson; Fiscal Year: 2005
    ..This award will support the pursuit of my long-term career goal, which is to become a proficient independent clinical investigator focusing on infections in the immunocompromised host. ..
  66. Characterization of Cellular Proteins Involved in HIV Infection
    WILLIAM O BRIEN; Fiscal Year: 2009
    ..Our proposal will identify human proteins as targets important for HIV infection that can be used to develop new classes of antiretroviral drugs. PHS 398/2590 (Rev. 11/07) Page 1 Continuation Format Page ..
  67. Tonsil Model of Oral HIV-1 Infection via Breastfeeding
    Diane Shugars; Fiscal Year: 2003
    ....
  68. Targeting regulators of cellular gene transcription to impact HIV latency
    Douglas Richman; Fiscal Year: 2009
    ..The objective is to assess the susceptibility of the latent reservoirs to therapeutic intervention with the ultimate goal of identifying inhibitors and establishing treatment paradigms suitable for clinical testing. ..
  69. Tonsil Model of Oral HIV-1 Infection via Breastfeeding
    Diane Shugars; Fiscal Year: 2002
    ....
  70. HIV-1 p24 based viral load assay in breast milk & serum
    ANDRZEJ DRUKIER; Fiscal Year: 2001
    ..This assay will also be used for VL testing of HIV-l Clade B-infected individuals as a first step towards a commercially viable assay. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  71. HIV-1 p24 based viral load assay in breast milk & serum
    ANDRZEJ DRUKIER; Fiscal Year: 2002
    ..This assay will also be used for VL testing of HIV-l Clade B-infected individuals as a first step towards a commercially viable assay. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  72. NK CELL ADCC AND CD4+ CELL APOPTOSIS IN HIV+ TISSUES
    Gail Skowron; Fiscal Year: 2003
    ..These relationships will be evaluated in the context of the clinical status of each patient group to be studied, and in comparison to HIV-uninfected subjects. ..