Genomes and Genes
Gene Symbol: CD9
Description: CD9 molecule
Alias: BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29, 5H9 antigen, BA-2/p24 antigen, CD9 antigen, CD9 antigen (p24), cell growth-inhibiting gene 2 protein, leukocyte antigen MIC3, motility related protein-1, tetraspanin-29
Publications237 found, 100 shown here
- Effects of K+ channel blockers on the action potential of hypoxic rabbit myocardiumE Ruiz Petrich
Department of Physiology and Biophysics, Faculty of Medicine, University of Sherbrooke, , Canada
Br J Pharmacol 106:924-30. 1992..and at least one yet unidentified current component rather insensitive to changes in [K]o and to K+ channel blockers...
- Complexes of tetraspanins with integrins: more than meets the eyeF Berditchevski
CRC Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, B15 2TA, UK
J Cell Sci 114:4143-51. 2001....
- Cell surface tetraspanin CD9 mediates chemoresistance in small cell lung cancerSatoshi Kohmo
Department of Respiratory Medicine, Allergy, and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Cancer Res 70:8025-35. 2010..We found that the tetraspanin family member CD9 was expressed preferentially in SCLC tumors and metastases from three of seven relapsed patients, whereas chemonaï..
- Tetraspanin CD9 in cell migrationDale Powner
School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Biochem Soc Trans 39:563-7. 2011Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion...
- Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motilityM Miyake
Department of Thoracic Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
J Exp Med 174:1347-54. 1991....
- Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNAS Ikeyama
Department VI, Takeda Chemical Industries, Ltd, Osaka, Japan
J Exp Med 177:1231-7. 1993..by monoclonal antibody (mAb) M31-15 inhibiting cell motility and that the sequence of MRP-1 coincides with that of CD9. In the present study, plasmid was constructed in which human MRP-1/CD9 cDNA is expressed under the control of the ..
- Lateral organization of membrane proteins: tetraspanins spin their webStephanie Charrin
INSERM, U, Villejuif, France
Biochem J 420:133-54. 2009....
- Reduced motility related protein-1 (MRP-1/CD9) gene expression as a factor of poor prognosis in non-small cell lung cancerM Higashiyama
Department of Surgery, Center for Adult Diseases of Osaka, Japan
Cancer Res 55:6040-4. 1995Motility related protein-1 (MRP-1) is a transmembrane glycoprotein that is identical to the CD9 antigen. In previous studies, we showed that various types of cultured tumor cells transfected with MRP-1/CD9 cDNA have low motility and ..
- Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linkingOleg V Kovalenko
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Biochem J 377:407-17. 2004..Evidence for constitutive CD9 homodimers was obtained using several cell lines, utilizing the following four methods: (1) spontaneous cross-..
- HIV-1 replication in dendritic cells occurs through a tetraspanin-containing compartment enriched in AP-3Eduardo Garcia
Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, 1211 Geneva, Switzerland
Traffic 9:200-14. 2008..stomatitis virus protein G colocalized in a viral compartment enriched in tetraspanins including CD81, CD82 and CD9, although at different levels, indicating a role of the viral envelope in targeting to the tetraspanin-rich ..
- Role of tetraspanins CD9 and CD151 in primary melanocyte motilityM Angeles Garcia-Lopez
Department of Dermatology, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
J Invest Dermatol 125:1001-9. 2005Tetraspanins CD9 and CD151 have been implicated in cellular motility and intercellular adhesion in several cellular types...
- CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanomaK J Radford
Oncology and Immunology Unit, David Maddison Clinical Sciences Building, Newcastle, New South Wales, Australia
Biochem Biophys Res Commun 222:13-8. 1996..These results are the first to demonstrate an association between CD63 and two other TM4SF members, CD9 and CD81 in 2 human melanoma cell lines...
- A specific microdomain ("glycosynapse 3") controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9Koji Mitsuzuka
Pacific Northwest Research Institute, Seattle, Washington 98122, USA
J Biol Chem 280:35545-53. 2005..is highly dependent on the organization and function of microdomains composed of integrin, proteolipid/tetraspanin CD9, and ganglioside (Ono, M., Handa, K., Sonnino, S., Withers, D. A., Nagai, H., and Hakomori, S...
- CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)K R Park
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
Mol Hum Reprod 6:252-7. 2000Recently we reported that CD9 is involved in the invasion of a trophoblast-like choriocarcinoma cell line, BeWo, probably through the regulation of integrin functions...
- Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrinP M Sincock
Department of Medicine, The University of Adelaide, Australia
J Histochem Cytochem 45:515-25. 1997It has recently been shown that several members of the tetraspan superfamily, including CD9 and CD63, associate with each other and with beta1 integrins...
- CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophagesEzequiel Ruiz-Mateos
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
J Virol 82:4751-61. 2008..into intracellularly sequestered plasma membrane domains that contain several other tetraspanins, including CD81, CD9, and CD53. CD63 is recruited to this domain following HIV infection...
- Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cellsJia Weng
Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
J Virol 83:7467-74. 2009..Overall, these data establish tetraspanins as negative regulators of HIV-1-induced cell-cell fusion, and they start delineating the requirements for this regulation...
- Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteinsKei Sato
Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara cho, Sakyo ku, Kyoto, Kyoto 606 8507, Japan
J Virol 82:1021-33. 2008..In addition, these behaviors were commonly observed in other tetraspanin proteins, such as CD9, CD81, CD82, and CD231...
- Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domainsClare Jolly
The Sir William Dunn School of Pathology, The University of Oxford, Oxford OX1 3RE, United Kingdom
J Virol 81:7873-84. 2007..glycoprotein (Env) and the core protein (Gag) colocalize strongly with CD63 and CD81 and less strongly with CD9, whereas no colocalization was seen between Env or Gag and the late endosome/lysosomal marker Lamp2...
- The major CD9 and CD81 molecular partner. Identification and characterization of the complexesS Charrin
INSERM U268, Hopital Paul Brousse, 94807 Villejuif Cedex, France
J Biol Chem 276:14329-37. 2001..We have previously identified a 135-kDa molecule (CD9P-1) as a major molecular partner of CD9 in cancer cell lines...
- Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrinsX A Zhang
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
J Biol Chem 276:25005-13. 2001..plasma membrane leads to their specific association with transmembrane-4 superfamily (TM4SF; tetraspanin) proteins (CD9, CD53, CD81, CD82, and CD151), as demonstrated by reciprocal co-immunoprecipitation and covalent cross-linking ..
- EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamilyC S Stipp
Dana Farber Cancer Institute and the Department of Pathology, Harvard Medical School, Boston, Mssachusetts 02115, USA
J Biol Chem 276:40545-54. 2001..EWI-2 associated specifically with CD9 and CD81 but not with other tetraspanins or with integrins...
- Down-regulation of CD9 expression during prostate carcinoma progression is associated with CD9 mRNA modificationsJia Chi Wang
McMaster University Medical Centre, Hamilton, Ontario, Canada
Clin Cancer Res 13:2354-61. 2007Cluster-of-differentiation antigen 9 (CD9) protein, a member of the tetraspanin family, has been implicated in carcinogenesis of various human tumors...
- Tetraspanins CD9 and CD81 modulate HIV-1-induced membrane fusionMónica Gordón-Alonso
Servicio de Inmunologia, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
J Immunol 177:5129-37. 2006..Therefore, the role of CD81 and other related tetraspanin, CD9, on the cell-to-cell fusion process mediated by HIV-1 was studied...
- Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylationStephanie Charrin
INSERM U268, Hopital Paul Brousse, 94807 Cedex, Villejuif, France
FEBS Lett 516:139-44. 2002..All tetraspanins studied, CD9, CD37, CD53, CD63, CD81, CD82 and CD151, were found to incorporate [3H]palmitate...
- Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1Sascha Nydegger
Graduate Program in Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
J Cell Biol 173:795-807. 2006..Here, we reveal the presence of tetraspanin-enriched microdomains (TEMs) containing the tetraspanins CD9, CD63, CD81, and CD82 at the plasma membrane...
- Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactionsV Serru
INSERM U268, Hopital Paul Brousse, 94807 Villejuif Cedex, France
Biochem J 340:103-11. 1999..mild detergent, digitonin, dissociated most of these associated molecules, including integrins, from the tetraspans CD9, CD37, CD53, CD63, CD82, Co-029, Talla-1 and NAG-2...
- FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated proteinC S Stipp
Dana Farber Cancer Institute and the Department of Pathology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
J Biol Chem 276:4853-62. 2001CD81 and CD9, members of the transmembrane-4 superfamily (TM4SF; tetraspanins), form extensive complexes with other TM4SF proteins, integrins, and other proteins, especially in mild detergents...
- Immunohistochemically detected expression of motility-related protein-1 (MRP-1/CD9) in lung adenocarcinoma and its relation to prognosisM Higashiyama
Department of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinariku, Japan
Int J Cancer 74:205-11. 1997Motility-related protein-1 (MRP-1)/CD9 is a trans-membrane glycoprotein closely associated with suppression of cell motility and reduced metastatic potential of some tumor cells...
- Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivityR Iwamoto
Institute of Life Science, Kurume University, Fukuoka, Japan
EMBO J 13:2322-30. 1994DRAP27, the monkey homolog of human CD9 antigen (DRAP27/CD9) and diphtheria toxin receptor (DTR) were expressed in mouse L cells...
- CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82G Horvath
INSERM U268, Hopital Paul Brousse, 94807 Villejuif Cedex, France
J Biol Chem 273:30537-43. 1998..4 transmembrane domains, member of the tetraspan superfamily, is engaged, together with other tetraspans such as CD9, CD53, CD63, and CD82, in multimolecular complexes containing beta1 integrins and major histocompatibility complex ..
- CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspansS Lozahic
INSERM U268, Hopital Paul Brousse, Villejuif, France
Eur J Immunol 30:900-7. 2000..raised and selected monoclonal antibodies (mAb) for their ability to immunoprecipitate a molecule associated with CD9. A unique mAb was identified which recognizes the complement regulator CD46 (membrane cofactor protein)...
- Latent transforming growth factor beta-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursorJoanna S Brooke
Dept of Biological Science, DePaul University, Chicago, IL 60614, USA
BMC Cell Biol 3:2. 2002..cDNA clones containing nucleotide sequences encoding domains of two proteins were obtained and their derived amino acid sequences were evaluated...
- A functionally relevant conformational epitope on the CD9 tetraspanin depends on the association with activated beta1 integrinMaria Dolores Gutierrez-Lopez
Instituto de Farmacologia y Toxicologia CSIC UCM, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
J Biol Chem 278:208-18. 2003..The tetraspanin CD9 has been implicated in cell motility, metastasis, and sperm-egg fusion...
- Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63V Horejsi
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague
FEBS Lett 288:1-4. 1991..of the recently described leucocyte surface (glyco)-proteins with significant amino acid sequence similarity (human CD9, CD37, CD53, CD63, TAPA-1, CO-029 and R2 and several homologues of other species) are distinguished by the ..
- Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusionKeisuke Kaji
Department of Life Science, Tokyo Institute of Technology, Yokohama, 226 8501, Japan
Dev Biol 247:327-34. 2002b>CD9 is a membrane protein belonging to the tetraspanin family...
- Calcium antagonist and antiperoxidant properties of some hindered phenolsG P Sgaragli
Istituto di Scienze Farmacologiche, Siena, Italy
Br J Pharmacol 110:369-77. 1993..8. Di-t-BHA is proposed as a lead reference compound for future synthesis of new antioxidants combining two potentially useful properties in the prevention of tissue damage after ischaemia reperfusion injury...
- Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytesL Folgueira
Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Virol 70:223-31. 1996..Altogether, these results suggest that atypical PKC isoenzymes, including PKC-zeta, participate in the signal transduction pathways by which HIV infection results in the activation of NF-kappa B in human monocytic cells and macrophages...
- Muscarinic (M1) receptor-mediated inhibition of K(+)-evoked [3H]-noradrenaline release from human neuroblastoma (SH-SY5Y) cells via inhibition of L- and N-type Ca2+ channelsR L McDonald
Department of Pharmacology, University of Leeds
Br J Pharmacol 113:621-7. 1994..Keywords: SH-SY5Y; calcium channels; noradrenaline release; muscarinic receptor; nifedipine; w-conotoxin GVIA; pirenzepine;hexahydrosiladiphenidol..
- Blockade by ifenprodil of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones: comparison with N-methyl-D-aspartate receptor antagonist actionsJ Church
Department of Anatomy, University of British Columbia, Vancouver, Canada
Br J Pharmacol 113:499-507. 1994..Keywords: Ifenprodil; voltage-activated calcium channels; N-methyl-D-aspartate (NMDA); polyamines; cultured hippocampal pyramidal neurones..
- Evidence for an external location of the dihydropyridine agonist receptor site on smooth muscle and skeletal muscle calcium channelsC Strübing
Institut fur Biochemische Pharmakologie, Innsbruck, Austria
Br J Pharmacol 108:884-91. 1993..The DHP binding domain can be reached by agonists and antagonists from the extracellular but not from the intracellular face of the membrane...
- Modulation of calcium channel currents by arachidonic acid in single smooth muscle cells from vas deferens of the guinea-pigN Nagano
Department of Chemical Pharmacology, Faculty of Pharmacentical Science, Nagoya City University, Japan
Br J Pharmacol 116:1887-93. 1995..The inhibition of Ca channel current by AA may be partly induced by superoxide radicals derived from AA oxidation. PGF2A also reduces Ca channel currents but probably by a separate mechanism via activation of a GTP binding protein...
- Homing of the myeloma cell cloneK Vanderkerken
Department of Hematology-Immunology, Free University Brussels, Belgium
Acta Oncol 39:771-6. 2000..analysis we demonstrated that the stroma-dependent MM5 cells show a downregulation of the motility-related protein (MRP-I CD9) which might reflect the involvement of this molecule in the regulation of myeloma cell extravasation.
- The effect of supplemental beta-carotene on immunologic indices in patients with AIDS: a pilot studyD A Fryburg
Division of Endocrinology and Metabolism, Yale University School of Medicine, New Haven, Connecticut, USA
Yale J Biol Med 68:19-23. 1995..These preliminary observations suggest that short-term treatment with beta-carotene may increase CD4+ cell counts in patients with AIDS who have greater than 10 cells/microliters...
- Raman spectroscopy of DNA-metal complexes. I. Interactions and conformational effects of the divalent cations: Mg, Ca, Sr, Ba, Mn, Co, Ni, Cu, Pd, and CdJ Duguid
Department of Biochemistry, University of Minnesota, St Paul 55108
Biophys J 65:1916-28. 1993..Metal cation linkage of two displaced bases would allow separate DNA strands to crosslink. Aggregation is proposed to result from the formation of an extended network of these crosslinks...
- Intravenous immunoglobulin in symptomatic and asymptomatic children with perinatal HIV infectionL Olopoenia
Department of Pediatrics, DC General Hospital, Washington, DC 20012, USA
J Natl Med Assoc 89:543-7. 1997..However, symptomatic patients responded much better than the asymptomatic patients...
- Evaluation of surface tension and ion occupancy effects on gramicidin A channel lifetimeA Ring
Department of Physiology and Medical Biophysics, Uppsala University, Sweden
Biophys J 53:541-8. 1988..These effects of blockers, osmotic agents, and voltage on the lifetime, as well as the lack of effect of voltage at low salt levels, are consistent with the occupancy hypothesis...
- [Strip immunoblot assay (SIA) with recombinant antigens and synthetic peptide for detection of anti HIV-1 and HIV-2 antibodies]M Deguchi
Laboratory for Clinical Investigatio, Osaka University Hospital
Kansenshogaku Zasshi 75:371-81. 2001..The SIA method indicated the positive readings earlier than the WB1 assay. The present findings indicated that the SIA method was more specific and sensitive than the WB assay, and would be useful as a confirmatory test...
- Investigations into neuropeptide Y-mediated presynaptic inhibition in cultured hippocampal neurones of the ratD Bleakman
Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637
Br J Pharmacol 107:334-40. 1992..These results are consistent with a localized presynaptic inhibitory effect of NPY on glutamate release in hippocampal neurones in culture...
- Strychnine-induced potassium current in CA1 pyramidal neurones of the rat hippocampusS Ebihara
Department of Neurophysiology, Tohoku University School of Medicine, Sendai, Japan
Br J Pharmacol 106:823-7. 1992..7. When neurones were loaded with cholera toxin (CTX) or pertussis toxin (PTX) through a patch pipette, PTX suppressed the Str response whereas CTX did not, suggesting that G, and/or Go might be involved in the Str-induced IK...
- Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family membersJ Fullekrug
Cell Biology and Cell Biophysics Program, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Mol Biol Cell 10:1939-55. 1999....
- Kinin-induced chloride permeability changes in colony 29 epithelia estimated from 125I- efflux and MEQ fluorescenceL J MacVinish
Department of Pharmacology, University of Cambridge
Br J Pharmacol 108:469-78. 1993..7. It is concluded that LBK increases electrogenic chloride secretion in Colony 29 epithelia through the generation of second messengers cyclic AMP and Ca2+, each of which may act on both apical and basolateral membranes...
- K+ current stimulation by Cl- in the midgut epithelium of tobacco hornworm (Manduca sexta). II. Analysis of Ba(2+)-induced K+ channel conduction noiseW Zeiske
, , FRG
J Comp Physiol B 162:340-4. 1992..It seems likely that basolateral K+ channels (1) are subject to anionic gating ligands, and (2) depend on anions with respect to the rate of K+ transfer through an open K+ channel...
- The ambulatory care of HIV-infected persons: a survey of physician practice patternsM D Stein
Division of General Internal Medicine, Rhode Island Hospital, Providence 02903
J Gen Intern Med 7:180-6. 1992..Such incorporation might increase guideline acceptance by practicing clinicians...
- [A case of primary HIV-1 infection]H Sugiyama
Department of Internal Medicine, Teikyo University School of Medicine
Kansenshogaku Zasshi 71:949-52. 1997..Diagnosis of primary HIV-1 infection was made. Recently, HIV-1 infection has been increasing in Japan. Consideration of this disease in differential diagnosis of acute febrile illness is necessary...
- Ionic currents in cardiac myocytes of squid, Alloteuthis subulataM P Odblom
Marine Biological Association, Plymouth, UK
J Comp Physiol B 170:11-20. 2000..It also had a more transient time course, was activated at more negative potentials, and resembled the previously described low-voltage-activated, T-type calcium current...
- Detection of simian T-lymphotropic virus type I using the polymerase chain reactionC S Dezzutti
Department of Veterinary Pathobiology, Ohio State University, Columbus 43210
Int J Cancer 50:805-10. 1992..Additionally, our data suggest that the tax and pol gene regions are conserved between HTLV-I and STLV-I strains found among these diverse species of non-human primates...
- Regulation of a voltage-dependent, calcium-activated K conductance by cyclic GMP in dissociated flounder enterocytesK E Cooper
Department of Physiology and Animal Sciences, University of Minnesota, St Paul 55108
J Comp Physiol B 163:581-6. 1993..l-1 Ba2+ to cells bathed in symmetric K Ringer's solution resulted in nearly complete inhibition of outward current. Charybdotoxin produced only minor effects on this current.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Differential in vitro anti-HIV activity of natural lignansH C Schroder
Abteilung Angewandte Molekularbiologie, Universitat Mainz, Bundesrepublik Deutschland
Z Naturforsch C 45:1215-21. 1990..Our results suggest that both compounds prevent the increase of topoisomerase II activity, involved in virus replication, after infection of cells with HIV-1...
- Boronate affinity adsorption of RNA: possible role of conformational changesN Singh
Department of Chemical Engineering, University of Houston, TX 77204-4792, USA
J Chromatogr A 840:205-13. 1999..The stoichiometric displacement parameter, Z, in Ba2+ buffer is three times the value in Mg2+ buffer, and is close to unity...
- Adenosine-induced hyperpolarization of the membrane voltage in rat mesangial cells in primary cultureH Pavenstadt
Department of Medicine, Albert Ludwigs University, Freiburg, Germany
Br J Pharmacol 113:7-12. 1994..6. The data indicate that adenosine activates K+-conductance via an A2 receptor in mesangial cells; the activation of the K+-conductance, which is probably mediated by cyclic AMP led to a hyperpolarization of membrane voltage...
- Effects of divalent cations and La3+ on contractility and ecto-ATPase activity in the guinea-pig urinary bladderA U Ziganshin
Department of Anatomy, University College London
Br J Pharmacol 114:632-9. 1995..5. In conclusion, the ability of some divalent cations to inhibit ecto-ATPase activity and to potentiate or inhibit contractile responses in the guinea-pig urinary bladder appear to be independent effects...
- Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptaseOSMOND J D'CRUZ
Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
Biol Reprod 67:1959-74. 2002....
- The P2Z-purinoceptor of human lymphocytes: actions of nucleotide agonists and irreversible inhibition by oxidized ATPJ S Wiley
Haematology Department, Austin Hospital, Heidelberg, Victoria, Australia
Br J Pharmacol 112:946-50. 1994....
- [Prevalence of HIV infection among stable female partners of seropositive men]S Kimura
Department of Infectious Diseases and Applied Immunology, University of Tokyo
Kansenshogaku Zasshi 67:95-101. 1993..01). HIV-p24 antigen was measured in 10 of 11 seropositive men. The antigen was positive in four men, and negative in six.(ABSTRACT TRUNCATED AT 250 WORDS)..
- A study of the interaction between the Na+, K+ pump and Na+:Ca2+ exchange in macrophages and vascular smooth muscle cellsC Galli
INSERM U7, , Paris, France
Am J Hypertens 1:64S-70S. 1988..2',4'-Dimethylbenzamil was also able to inhibit Na+ efflux (by 3.05 +/- 0.98 mmol (L cells X h)-1; mean +/- SEM of three experiments) suggesting the existence of Na+:Sr2+ exchange.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Surrogate markers for survival in patients with AIDS and AIDS related complex treated with zidovudineM A Jacobson
Department of Medicine, University of California, San Francisco
BMJ 302:73-8. 1991....
- [The detection of human immunodeficiency virus type 1/2 antibody using synthetic peptides]P Mao
Department of Virology, 302nd Hospital of PLA, Beijing 100039
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:72-4. 1997..The reagent are stable at 37 degrees C for 4 days. The results indicated that our reagent is highly specific, sensitive and stable, it can be used for detection of HIV-1/2 infections...
- [Study on reverse transcriptase inhibiting antibody in plasma of HIV-1 seropositive subjects]T Saito
Department of Virology, Kanagawa Prefectural Public Health Laboratories
Kansenshogaku Zasshi 69:851-7. 1995..HIV strains were isolated from these 3 cases. These results suggest that reduction of RT inhibiting antibody levels correlate well with the success of HIV isolation and with progression of clinical manifestation...
- Analogies and differences between omega-conotoxins MVIIC and MVIID: binding sites and functions in bovine chromaffin cellsL Gandia
Departamento de Farmacologia, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo, 4, E 28029 Madrid, Spain
Pflugers Arch 435:55-64. 1997....
- Separation of calcium channel current components in mouse chromaffin cells superfused with low- and high-barium solutionsJ M Hernandez-Guijo
Instituto de Farmacología Teófilo Hernando y Departamento de Farmacología, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 4, E 28029 Madrid, Spain
Pflugers Arch 436:75-82. 1998....
- Re-evaluation of the P/Q Ca2+ channel components of Ba2+ currents in bovine chromaffin cells superfused with solutions containing low and high Ba2+ concentrationsA Albillos
Departamento de Farmacologia, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo, 4 E 28029 Madrid, Spain
Pflugers Arch 432:1030-8. 1996..An R-type residual current is not present in these cells...
- [Studies on maternal transmission of HIV-1]Y Tabei
Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health
Kansenshogaku Zasshi 69:858-63. 1995..None of the HIV-1 markers, except for antibody, was detected in the samples from their children and placenta. These facts strongly suggest that there was no HIV-1 transmission from mother to child...
- [Study on molecular epidemiology of Borna disease virus in Zunyi regions of Guizhou province]Chang ming Wang
Department of Neruology, 1st Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China
Zhonghua Liu Xing Bing Xue Za Zhi 29:1213-6. 2008..In order to study the epidemiology of Borna disease virus (BDV) in Zunyi region and its surrounding regions in Guizhou province...
- Ionic currents and inhibitory effects of glibenclamide in seminal vesicle smooth muscle cellsH Sadraei
Department of Pharmacology, University of Leeds
Br J Pharmacol 115:1447-54. 1995..In addition, an unexpected relaxant effect of high concentrations of glibenclamide may be explained by inhibition of the Ca channels...
- Development of a monoclonal antibody-based p24 capsid antigen detection assay for HTLV-I, HTLV-II, and STLV-I infectionG Toedter
Coulter Immunology, Hialeah, Florida
AIDS Res Hum Retroviruses 8:527-32. 1992..Similarly, normal human peripheral blood mononuclear cells and uninfected, transformed human T cells, were also negative in the assay.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Didanosine therapy in patients intolerant of or failing zidovudine therapyR C Rathbun
Section of Pharmacy Practice, College of Pharmacy, University of Oklahoma, Oklahoma City, OK 73190
Ann Pharmacother 26:1347-51. 1992..Also, development of peripheral neuropathy may occur at lower cumulative doses in these patient populations...
- Measurement of HIV-1 p24 antigen by signal-amplification-boosted ELISA of heat-denatured plasma is a simple and inexpensive alternative to tests for viral RNAJorg Schupbach
Swiss National Center for Retroviruses, University of Zurich, Gloriastr 30, CH 8028 Zurich Switzerland
AIDS Rev 4:83-92. 2002..There is no problem with sample instability and no need for cumbersome nucleic acid extraction. The test is validated for subtype B, but requires further studies for non-B subtypes...
- Different modes of electrogenic Na+ absorption in the coprodeum of the chicken embryo: role of extracellular Ca2+M Heinz
, , Federal Republic of Germany
J Comp Physiol B 161:363-70. 1991..The results indicate that Na+ absorption in the coprodeum of the chicken embryo is more complex than in adult hens.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Separation and detection of common mono- and divalent cations by ion chromatography with an ODS column and conductivity/UV detectionK Ito
Department of Environmental Science, Faculty of Engineering, Hiroshima University, Japan
J Chromatogr A 850:247-56. 1999..CD detection was possible for M+ and M2+ and UV detection for M2+. (3) For M2+, the mobile phase, 0.8 mM Ce(III) + 0.1 mM SDS + 1 mM HNO3 and indirect UV detection were effective. The IC methods were applied to real samples...
- Sensitivity and specificity of anti-HIV ELISA employing recombinant (p24, p66, gp120) and synthetic (gp41) viral antigenic peptidesG Filice
Department of Infectious Diseases, University of Pavia, IRCCS Policlinico S Matteo
Microbiologica 14:185-94. 1991..b...
- Intracellular pH transients of mammalian astrocytesM Chesler
Department of Neurology, Cornell University Medical College, New York, New York 10021
J Neurosci 9:2011-9. 1989..The sensitivity of the response to Ba2+ suggests that it is triggered by membrane depolarization. These results suggest that glial pHi is normally modulated by the level of local neuronal activity...
- Inhibition of the P-glycoprotein- and multidrug resistance protein-mediated efflux of anthracyclines and calceinacetoxymethyl ester by PAK-104PC Marbeuf Gueye
, , 74 rue Marcel Cachin, Bobigny, France
Eur J Pharmacol 391:207-16. 2000..A second mechanism involving a high-affinity site for PAK-104P and which would concern molecules such as anthracyclines, calcein acetoxymethyl ester whose efflux depends on the presence of glutathione...
- On the mechanisms of cholinergic control of the sinoatrial node dischargeM Vassalle
Department of Physiology and Pharmacology, State University of New York, Brooklyn 11203, USA
J Cardiovasc Pharmacol 37:173-86. 2001..The results with Cs+ and Ba2+ indicate that both high and low concentrations of carbachol decrease sinoatrial node discharge by activating the I(K,ACh) channels rather than by decreasing If...
- The effect of treatment with zidovudine with or without acyclovir on HIV p24 antigenaemia in patients with AIDS or AIDS-related complexC Pedersen
Hvidovre Hospital, Copenhagen, Denmark
AIDS 6:821-5. 1992..Change in antigen level in response to antiviral therapy needs further investigation before it is used as a surrogate marker for clinical efficacy of antiviral therapy...
- Dual and recombinant infections: an integral part of the HIV-1 epidemic in BrazilA Ramos
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Emerg Infect Dis 5:65-74. 1999....
- Preliminary comparison of precursor scans and liquid chromatography-tandem mass spectrometry on a hybrid quadrupole time-of-flight mass spectrometerC Borchers
Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Chromatogr A 854:119-30. 1999..LC-MS-MS, therefore, appears to be better for the detection of trace components in complex mixtures...
- [Analysis of immunophenotype and leukemia associated immunophenotype in 610 patients with acute myeloid leukemia]Yan Rong Liu
Peking University, Institute of Hematology, People s Hospital, Beijing, China
Zhonghua Xue Ye Xue Za Zhi 28:731-6. 2007..To analyze the immunophenotype and leukemia associated immunophenotype (LAIP) of leukemia cells from patients with acute myeloid leukemia (AML) in minimal residual disease (MRD) detection...
- Lymph node architecture preceding and following 6 months of potent antiviral therapy: follicular hyperplasia persists in parallel with p24 antigen restoration after involution and CD4 cell depletion in an AIDS patientJ M Orenstein
Department of Pathology, George Washington University Medical Center, Washington, DC 20037, USA
AIDS 13:2219-29. 1999..To evaluate changes in architecture, viral RNA, and viral protein over 6 months in lymph nodes from retroviral-naïve HIV-infected persons before and after commencing highly active antiretroviral therapy (HAART)...
- Production and purification of immunologically active core protein p24 from HIV-1 fused to ricin toxin B subunit in E. coliAlberto J Donayre-Torres
Centro de Investigación y de Estudios Avanzados Cinvestav, Unidad Irapuato, Km 9 6 Libramiento Norte, 36500 Carretera Irapuato León, Irapuato, Guanajuato, Mexico
Virol J 6:17. 2009..The aim of this study was to investigate the adjuvant-carrier properties of the B ricin subunit (RTB) when fused to p24...
- Mechanisms underlying burst generation of the pyloric muscle in the mantis shrimp, Squilla oratoriaK Tazaki
Biological Laboratory, Nara University of Education, Japan
J Comp Physiol A 169:737-50. 1991....
- Regional sublocalization of the human thyroid peroxidase gene (TPO) by tritium and fluorescence in situ hybridization to chromosome 2p25-->p24P S Barnett
Department of Medicine, King's College School of Medicine and Dentistry, London, UK
Cytogenet Cell Genet 62:188-9. 1993..Based on the results of a study using both isotopic and nonisotopic in situ hybridization, we assign the gene coding for human TPO to chromosome region 2p25-->p24...
- Progression to AIDS in patients with lymphadenopathy or AIDS-related complex: reappraisal of risk and predictive factorsH W Murray
Division of Infectious Diseases, Cornell University Medical College, New York, New York
Am J Med 86:533-8. 1989....
- Proline residues in the HIV-1 NH2-terminal capsid domain: structure determinants for proper core assembly and subsequent steps of early replicationT Fitzon
Institute of Medical Microbiology, Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, D 93053, Germany
Virology 268:294-307. 2000..These results suggest that proline residues in the NH(2)-terminal capsid domain represent critical structure determinants for proper formation of functional virion cores and subsequent stages of early replication...
- CD9-dependent regulation of Canine distemper virus-induced cell-cell fusion segregates with the extracellular domain of the haemagglutininK Singethan
Institut fur Virologie und Immunbiologie, Versbacher Strasse 7, D 97078 Wurzburg, Germany
J Gen Virol 87:1635-42. 2006Antibodies to CD9, a member of the tetraspan transmembrane-protein family, selectively inhibit Canine distemper virus (CDV)-induced cell-cell fusion...
- [Investigation of a new HIV-1 p24 antigen detection kit based on the enzyme-linked fluorescent immunoassay]T Hayashi
Department of Virology, Kanagawa Prefectural Public Health Laboratory
Kansenshogaku Zasshi 74:709-15. 2000..The results obtained suggest that ELFA are very useful for an earlier diagnosis of HIV infection and re-test for false positive samples by other HIV diagnosis kits...
- Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammationMayumi Suzuki
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan
J Immunol 182:6485-93. 2009..In the present study, the role of tetraspanin CD9 in LPS-induced macrophage activation and lung inflammation was investigated in vitro and in vivo...
- Quantification of human immunodeficiency virus type 1 p24 antigen and antibody rivals human immunodeficiency virus type 1 RNA and CD4+ enumeration for prognosis. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical J S Read
Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
Pediatr Infect Dis J 19:544-51. 2000....
- [Evaluation of an HIV screening assay kit for the combined detection of anti-HIV-1/2 antibodies and HIV p24 antigen]T Shima
Department of Virology, Kanagawa Prefectural Public Health Laboratory, Yokohama City University Hospital, School of Medicine
Kansenshogaku Zasshi 75:1014-24. 2001..All of these specimens were positive by Genscreen HIV Ag-Ab. Therefore, Genscreen HIV Ag-Ab that shorten the window period is a useful and reliable for HIV screening test, especially in case of primary infection...
- Viral load, viral phenotype modification, zidovudine susceptibility and reverse transcriptase mutations during the first 6 months of zidovudine monotherapy in HIV-1-infected peopleS Rusconi
Clinica delle Malattie Infettive, Universita di Milano, Ospedale Luigi Sacco, Italy
Antivir Ther 1:211-9. 1996..076). SI phenotype was associated with the development of a decreased zidovudine susceptibility. A correlation between zidovudine-associated pol gene mutations and SI phenotype was detected at the 6-month time point...
- Ba2+ ions evoke two kinetically distinct patterns of exocytosis in chromaffin cells, but not in neurohypophysial nerve terminalsE P Seward
Department of Neurobiology and Anatomy, Medical College of Pennsylvania, Philadelphia 19129, USA
J Neurosci 16:1370-9. 1996..Only a single kinetic pattern is detected in NHP terminals, suggesting that mechanisms for secretion are not universally distributed in excitable cells...
- Pharmacology of Antiretroviral Nanoparticle MicellesChristopher J Destache; Fiscal Year: 2010..Due to the nanoparticle small size, the particles will stay in tissue longer and allow for less frequent dosing. This nanoparticle delivery system could affect the future of HIV- 1 treatment. ..
- COMBINATORIAL-DESIGNED NANO-PLATFORMS TO OVERCOME TUMOR DRUG RESISTANCEZhenfeng Duan; Fiscal Year: 2013..and cytotoxic drugs for maximum cell-kill effect. ..
- Point-of-Care HIV Antigen/Antibody Diagnostic DeviceMichael J Lochhead; Fiscal Year: 2011..The technology will be used in multi-test algorithms in public health laboratories, STD clinics, urban emergency departments, targeted outreach programs,etc., both in the United States and worldwide. ..
- Point-of-Care HIV Antigen/Antibody Diagnostic DeviceMichael J Lochhead; Fiscal Year: 2013..The outcome of this program will be a system design and dataset for an FDA investigational device exemption (IDE) meeting in advance of clinical trials. ..
- FUNCTIONS OF PREGNANCY SPECIFIC GLYCOPROTEINSGabriela S Dveksler; Fiscal Year: 2010..We determined that murine Psg17 and Psg19 bind to the tetraspanin CD9 but the activity and receptor usage of the other 15 members of the murine Psg family remains to be studied...
- Variation in platelet function: the genetics of platelet gene expressionPaul F Bray; Fiscal Year: 2013..of genes regulating the platelet response to specific agonists (ADP, CRP, collagen, TRAP, U46619, ristocetin, CD9 and epinephrine), as well as genes common to multiple platelet stimuli, and permit assessment of the effects of ..
- Epididymal PMCA4 Expression Functional Impact and Mechanism of Sperm UptakePATRICIA ANASTASIA DELEON; Fiscal Year: 2013..of membranous vesicles or epididymosomes, in delivering PMCA4/a to the sperm surface, assisted by the presence of CD9 tetraspanin which mediates cell-to-cell protein transfer via membrane fusion...
- The STOP StudyCynthia L Gay; Fiscal Year: 2013..This has momentous public health implications since individuals with AHI appear to continue to engage in the high-risk behaviors that led to recent HIV acquisition, particularly if they do not know they are infected. ..
- New HIV/AIDS vaccines employing inflammatory dendritic cellsChae Gyu Park; Fiscal Year: 2012..Successful harnessing of inflammatory dendritic cells also impacts on developing vaccines against other infections and cancer. ..
- Mycoplasma pneumoniae Gliding MotilityDuncan C Krause; Fiscal Year: 2012..pneumoniae in onset and recurrence of asthma. The studies proposed here will elucidate the mechanism and role of gliding motility in the colonization of the conducting airways. ..
- Mechanism of neurological and cognitive side effects of sevoflurane anesthesia atAnatoly E Martynyuk; Fiscal Year: 2013....
- Immunomodulatory Function of Human T Cell Leukemia Virus Type 2 (HTLV-2)Mark A Beilke; Fiscal Year: 2012..The proposed studies will focus on exploring possible strategies for immune based therapy of HIV infected patients. ..
- The STOP StudyMSC WESTHEIMER; Fiscal Year: 2013..Early diagnosis and notification can improve health outcomes by facilitating early referral to treatment. ..
- Multi-Ion, Free Energy Study of Effect of Ba2+ Blockage on KcsA Ion SelectivityKAREN MICHELLE CALLAHAN; Fiscal Year: 2013....
- Ultra-sensitive method for HIV p24 antigen detectionSIMON BYSTRYAK; Fiscal Year: 2012..Successful completion of these studies will be beneficial for public health, and make available all of the technology needed for a substantial business opportunity to license the technology and manufacture commercial products. ..
- HIV INFECTION OF HUMAN PLACENTAL CELLSKathleen McGann; Fiscal Year: 1993....
- Novel 99mTc(III) Complexes as SPECT Radiotracers for MPIShuang Liu; Fiscal Year: 2013....
- Social experience and remodeling of amygdalar circuits in rat adolescenceHOLLY MARIE MOORE; Fiscal Year: 2010..Moreover, the findings will contribute to the development of novel strategies for preventing the psycho- and neuropathology associated with many psychiatric disorders including schizophrenia, anxiety, and substance abuse disorders. ..
- BIOPHYSICAL/GENETIC PROPERTIES OF HIV1 IN HUMAN PLASMAGeorge Shaw; Fiscal Year: 2007..abstract_text> ..
- Targeting regulators of cellular gene transcription to impact HIV latencyDouglas D Richman; Fiscal Year: 2010..abstract_text> ..
- Characterization of the immunity induced by a DEC205-targeted HIV vaccineMarina Caskey; Fiscal Year: 2013..DEC205 HIV vaccine delivers HIV proteins to DCs and induces immune responses against HIV. ..
- Tetraspanins in Asthma and Eosinophilic Lung DiseasePraveen Akuthota; Fiscal Year: 2010..The specific aims of the research proposed will investigate the following hypotheses: 1) the tetraspanin CD9 is associatedwith antigen-presentation machinery in human eosinophils, 2) MHC Class II Is located predominantly in ..
- Characterization of tetraspanin-EWI protein complexes and functionsMartin E Hemler; Fiscal Year: 2011DESCRIPTION (provided by applicant): Tetraspanin proteins CD9 and CD81 regulate sperm-egg fusion, cell growth and proliferation, tumor cell motility and metastasis, and other functions...
- Smart Polymer Reagents for Sensitivity and Speed-enhanced Clinical DiagnosticsThomas Schulte; Fiscal Year: 2012..This project evaluates the promise of a newly developed smart reagent to enable more sensitive and faster clinical assays, and thus to contribute to better medical care. ..
- Modulation of Dendritic Cells against HIV-1Dinesh K Singh; Fiscal Year: 2011..But the intracellular molecules participating in trafficking of HIV within DCs are not clear. Tetraspanins such as CD9, CD63 and CD81 colocalize with HIV-1 particles in endosomes, but their exact role in this milieu has not been fully ..
- Dissecting the opposing roles of alpha-3 integrin in metastasisChristopher S Stipp; Fiscal Year: 2013..In particular, the loss of tetraspanin CD9 in tumor cells is linked to enhanced metastasis in clinical and experimental studies...
- NANO-CHIP HIV DETECTION IN VULNERABLE POPULATIONSGlen N Gaulton; Fiscal Year: 2011....
- Preparation and Characterization of 2nd Generation HIV-1 Maturation Inhibitor DruCarl Wild; Fiscal Year: 2013....
- National AIDS Research Institute (NARI), Pune, INDIA: Clinical Trials UnitArun R Risbud; Fiscal Year: 2013..We feel confident that our participation in the NIH HIVAIDS clinical trial networks will compliment our national research priorities. ADMINISTRATIVE COMPONENT: ..
- Smart Polymer Reagents for Sensitivity and Speed-enhanced Clinical DiagnosticsThomas Schulte; Fiscal Year: 2013..The multiplex capabilities of these reagents and the potential for removal of serum interferences will be broadly applicable to other clinically important analytes. ..
- C. Perfringens to Induce Anti-HIV Mucosal ImmunityPhalguni Gupta; Fiscal Year: 2006..The proposed study provides a novel strategy to induce strong mucosal immunity against HIV-1 which can lead to development of an anti-HlV-1 oral vaccine due to its safety, low production cost and easy administration. ..
- HOST CELL INTERACTIONS BY PATHOGENIC BORRELIAEJOHN LEONG; Fiscal Year: 2000..platelet activation activity was apparently mediated by the integrin- associated platelet signaling molecule CD9. Relapsing fever spirochetes have also been shown to bind to erythrocytes, and we speculate that attachment of ..
- PHOSPHOLIPASES AND INSULIN SECRETIONBryan Wolf; Fiscal Year: 1999..In the second approach, we will determine the identity and role of the three proteins, p24, p50, and p95, that are coupled to Galphai following glucose stimulation of beta-cells. ..
- Oral HIV Pathogenesis and SheddingRobert Coombs; Fiscal Year: 2005..abstract_text> ..
- GU SITES AND CONSEQUENCES OF HIV INFECTIONJOHN KRIEGER; Fiscal Year: 1992..Insights into the mehanisms of sexual transmission of HIV and the effects of HIV infection on male reproductive function may have major implications for decreasing transmission of this deadly infection...
- Pathogenesis of Oropharyngeal HHV-8 InfectionAndrew Johnson; Fiscal Year: 2005..This award will support the pursuit of my long-term career goal, which is to become a proficient independent clinical investigator focusing on infections in the immunocompromised host. ..
- Characterization of Cellular Proteins Involved in HIV InfectionWILLIAM O BRIEN; Fiscal Year: 2009..Our proposal will identify human proteins as targets important for HIV infection that can be used to develop new classes of antiretroviral drugs. PHS 398/2590 (Rev. 11/07) Page 1 Continuation Format Page ..
- Tonsil Model of Oral HIV-1 Infection via BreastfeedingDiane Shugars; Fiscal Year: 2003....
- HIV-1 p24 based viral load assay in breast milk & serumANDRZEJ DRUKIER; Fiscal Year: 2002..This assay will also be used for VL testing of HIV-l Clade B-infected individuals as a first step towards a commercially viable assay. PROPOSED COMMERCIAL APPLICATION: Not Available ..
- NK CELL ADCC AND CD4+ CELL APOPTOSIS IN HIV+ TISSUESGail Skowron; Fiscal Year: 2003..These relationships will be evaluated in the context of the clinical status of each patient group to be studied, and in comparison to HIV-uninfected subjects. ..
- HIV COMPONENTS FOR THE DESIGN--ANTIVIRAL DESIGN/ANALYSISMICHAEL ROSSMANN; Fiscal Year: 1992..This will involve determining the structure of Fab components of neutralizing antibodies which bind to known epitopes on the viral surface...
- PERINATAL HIV INFECTIONS--PREVENTION OF CNS PATHOLOGYStanley Schwartz; Fiscal Year: 1999....
- COMBINATION THERAPY OF HIV INFECTIONDavid Parenti; Fiscal Year: 1992..We would also continue to design and implement 2 or 3 drug combination pilot trails using these and other promising drugs such as ddc, and IL-2...
- Vaccine with altered HIV antigensDanuta Kozbor; Fiscal Year: 2003..III) We will analyze protection levels achieved by DNA immunization with the modified Gag-Pol fusion constructs against intrarectal challenge with rVV expressing Gag and Pol proteins. ..
- NOVEL THERAPEUTIC APPROACHES IN HIV-ASSOCIATED LYMPHOMASThomas Kipps; Fiscal Year: 1993..Molecular biology, virology, and immunology have identified promising experimental therapies for HIV associated NHL. Collaboration between basic and clinical science offers hope of identifying new effective therapies...
- HOW DOES P24/CD9 FUNCTION IN CELL ADHESIONLisa Jennings; Fiscal Year: 1999DESCRIPTION: (Adapted from investigator's abstract) p24/CD9 is an integral membrane protein found on the surface of human blood platelets, lymphoid progenitor cells, mitogen-stimulated T and B cells, endothelial cells and other non-..