CD86

Summary

Gene Symbol: CD86
Description: CD86 molecule
Alias: B7-2, B7.2, B70, CD28LG2, LAB72, T-lymphocyte activation antigen CD86, B-lymphocyte activation antigen B7-2, BU63, CD86 antigen (CD28 antigen ligand 2, B7-2 antigen), CTLA-4 counter-receptor B7.2, FUN-1
Species: human
Products:     CD86

Top Publications

  1. Chen A, Li F, Du J, Zhang Y, Gong E, Shi X. [Expression of co-stimulatory molecule CD86 and its inducible co-stimulator in Crohn disease and their pathologic significance]. Beijing Da Xue Xue Bao Yi Xue Ban. 2009;41:620-4 pubmed
    To investigate the expression of co-stimulatory molecule CD86 and inducible co-stimulator(ICOS) in the intestinal mucosa of Crohn disease (CD) and to exlpore its pathologic significance...
  2. Azuma M, Ito D, Yagita H, Okumura K, Phillips J, Lanier L, et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature. 1993;366:76-9 pubmed
    ..We have generated a monoclonal antibody, IT2, that reacts with a 70K glycoprotein (B70)...
  3. Slavik J, Hutchcroft J, Bierer B. CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28. J Biol Chem. 1999;274:3116-24 pubmed
    Ligation of either CD80 (B7-1) or CD86 (B7-2), two principal ligands for CD28, is thought to skew the immune response toward Th1 or Th2 differentiation...
  4. Marin L, Moya Quiles M, Miras M, Muro M, Minguela A, Bermejo J, et al. Evaluation of CD86 gene polymorphism at +1057 position in liver transplant recipients. Transpl Immunol. 2005;15:69-74 pubmed
    ..The main co-stimulatory pathway involves the interaction of CD80 and CD86, expressed on the APCs, with their T cell counter-receptor, CD28 and CTLA-4...
  5. Pan X, Gao L, Liang W, Liu Y, Zhu Y, Tang M, et al. CD86 +1057 G/A polymorphism and the risk of colorectal cancer. DNA Cell Biol. 2010;29:381-6 pubmed publisher
    b>CD86 (B7-2), one of the costimulatory molecules on antigen-presenting cells, plays essential roles not only in autoimmunity and transplantation but also in tumor immunity...
  6. Freeman G, Gribben J, Boussiotis V, Ng J, Restivo V, Lombard L, et al. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science. 1993;262:909-11 pubmed
    ..It is likely that B7-2 provides a critical early costimulatory signal determining if the T cell will contribute to an immune response or become anergic. ..
  7. Muthumani K, Hwang D, Choo A, Mayilvahanan S, Dayes N, Thieu K, et al. HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro. Int Immunol. 2005;17:103-16 pubmed
    ..Vpr down-modulated the expression of several immunologically important molecules including CD40, CD80, CD83 and CD86 costimulatory molecules on MDM (monocyte-derived macrophage) and MDDC (monocyte-derived dendritic cells)...
  8. Chaudhry A, Das S, Hussain A, Mayor S, George A, Bal V, et al. The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs. J Immunol. 2005;175:4566-74 pubmed
    ..We now show that Nef also redistributes the costimulatory molecules CD80 and CD86 away from the cell surface in the human monocytic U937 cell line as well as in mouse macrophages and dendritic ..
  9. Quaranta M, Mattioli B, Giordani L, Viora M. The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS. FASEB J. 2006;20:2198-208 pubmed

More Information

Publications126 found, 100 shown here

  1. Corydon T, Haagerup A, Jensen T, Binderup H, Petersen M, Kaltoft K, et al. A functional CD86 polymorphism associated with asthma and related allergic disorders. J Med Genet. 2007;44:509-15 pubmed
    ..This region harbours the CD86 gene encoding the costimulatory B7.2 protein...
  2. Liu Y, Liang W, Gao L, Pan X, Chen T, Wang Y, et al. CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. Hum Immunol. 2010;71:1141-6 pubmed publisher
    ..Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecules (CD80/CD86) genes are important mediators of T-cell activation in the immune response...
  3. Landi D, Moreno V, Guino E, Vodicka P, Pardini B, Naccarati A, et al. Polymorphisms affecting micro-RNA regulation and associated with the risk of dietary-related cancers: a review from the literature and new evidence for a functional role of rs17281995 (CD86) and rs1051690 (INSR), previously associated with colorectal. Mutat Res. 2011;717:109-15 pubmed publisher
    ..Besides reviewing the available literature, we present here for the first time two SNPs (rs17281995 in CD86 and rs1051690 in INSR) previously associated with the risk of CRC in a Czech population are also associated with ..
  4. Mokart D, Textoris J, Chow Chine L, Brun J, Sannini A, Turrini O, et al. HLA-DR and B7-2 (CD86) monocyte expressions after major cancer surgery: profile in sepsis. Minerva Anestesiol. 2011;77:522-7 pubmed
    ..These molecules may be involved, in association with HLA-DR, in postoperative monocyte dysfunction. ..
  5. Wang W, Song H, Liu J, Song B, Cao X. CD86 + 1057G/A polymorphism and susceptibility to osteosarcoma. DNA Cell Biol. 2011;30:925-9 pubmed publisher
    b>CD86 (B7-2), one of the costimulatory molecules on antigen-presenting cells, plays essential roles not only in autoimmunity and transplantation but also in tumor immunity...
  6. Wang J, Zhou Y, Feng D, Yang H, Li F, Cao Q, et al. CD86 +1057G/A polymorphism and susceptibility to Ewing's sarcoma: a case-control study. DNA Cell Biol. 2012;31:537-40 pubmed publisher
    ..b>CD86 (B7-2) may affect cancer susceptibility by modulating T cell response...
  7. Corcoran K, Jabbour M, Bhagwandin C, Deymier M, Theisen D, Lybarger L. Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1). J Biol Chem. 2011;286:37168-80 pubmed publisher
    ..is the cell surface up-regulation upon DC maturation of peptide·MHC-II complexes and the costimulatory molecule CD86. It is now clear that these critical induction events involve changes in ubiquitin-dependent trafficking of MHC-II ..
  8. Xiang H, Zhao W, Sun Y, Qian W, Xing J, Zhou Y, et al. CD86 gene variants and susceptibility to pancreatic cancer. J Cancer Res Clin Oncol. 2012;138:2061-7 pubmed publisher
    Pancreatic cancer is one of the most lethal cancers worldwide. CD86 (B7-2) is a costimulatory molecule on antigen-presenting cells and plays critical roles in tumor immunity...
  9. Mazzio E, Bauer D, Mendonça P, Taka E, Soliman K. Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFNγ activated glioma cells. J Neuroimmunol. 2017;302:10-19 pubmed publisher
    ..following, IL-13, TNF-a, fracktaline, leptin, LIX, GM-CSF, ICAM1, L-Selectin, activin A, agrin, IL-1α, MIP-3a, B72/CD86, NGF, IL-1b, MMP-8, IL-1 R6, PDGF-AA, IL-2, IL-4, prolactin R, RAGE, IL-6, Thymus Chemokine-1, CNTF,IL-10 or TIMP-1...
  10. Liu Y, Li J, Chen S, Huang H, Cai H. The rLrp of Mycobacterium tuberculosis inhibits proinflammatory cytokine production and downregulates APC function in mouse macrophages via a TLR2-mediated PI3K/Akt pathway activation-dependent mechanism. Cell Mol Immunol. 2016;13:729-746 pubmed publisher
    ..Furthermore, rLrp did not attenuate proinflammatory cytokines or the expression of CD86 and major histocompatibility complex class-II induced by interferon-gamma in the macrophages of Toll-like receptor ..
  11. Zhu Y, Li X, Chen J, Chen T, Shi Z, Lei M, et al. The pentacyclic triterpene Lupeol switches M1 macrophages to M2 and ameliorates experimental inflammatory bowel disease. Int Immunopharmacol. 2016;30:74-84 pubmed publisher
    ..This was associated with a down-regulation of CD86, a typical marker of M1 macrophages, and an up-regulation of CD206, a typical M2 macrophage marker...
  12. Lee C, Guo Y, So K, Vijayan M, Guo Y, Wong V, et al. Soluble human leukocyte antigen G5 polarizes differentiation of macrophages toward a decidual macrophage-like phenotype. Hum Reprod. 2015;30:2263-74 pubmed publisher
    ..of macrophages with 'immuno-modulatory' characteristics, including reduced expression of M1 macrophage marker CD86 and increased expression of M2 macrophage marker CD163...
  13. Li Y, Xu Y, Lai Y, Liao S, Liu N, Xu P. Intranasal co-administration of 1,8-cineole with influenza vaccine provide cross-protection against influenza virus infection. Phytomedicine. 2017;34:127-135 pubmed publisher
    ..cell (DC) maturation and the expression of co-stimulatory molecules cluster of differentiation (CD)40, CD80 and CD86 in peripheral blood...
  14. Ribon M, Seninet S, Mussard J, Sebbag M, Clavel C, Serre G, et al. Neutrophil extracellular traps exert both pro- and anti-inflammatory actions in rheumatoid arthritis that are modulated by C1q and LL-37. J Autoimmun. 2019;98:122-131 pubmed publisher
    ..importantly RA NET were more stimulatory, leading to secretion of inflammatory cytokines and up-regulation of HLA/CD86/CD11b. IgG from ACPA-positive RA patients specifically recognized RA and even HD NET...
  15. Vega Angeles V, Terrazas L, Ledesma Soto Y, Jimenez L, Landa A. Taenia solium glutathione transferase fraction activates macrophages and favors the development of Th1-type response. Biosci Rep. 2019;39: pubmed publisher
    ..of IL-12, TNF, and IL-10 as well as the expression of nitric oxide synthase 2 inducible (Nos2) and CD86, but did not induce the expression of chitinase-like 3 (Chil3)...
  16. Garibaldi S, Barisione C, Marengo B, Ameri P, Brunelli C, Balbi M, et al. Advanced Oxidation Protein Products-Modified Albumin Induces Differentiation of RAW264.7 Macrophages into Dendritic-Like Cells Which Is Modulated by Cell Surface Thiols. Toxins (Basel). 2017;9: pubmed publisher
    ..changes were evaluated by microscopic observation, while markers of dendritic lineage and activation (CD40, CD86, and MHC class II) and allogeneic T cell proliferation were evaluated by flow cytometry...
  17. Fueldner C, Kohlschmidt J, Riemschneider S, Schulze F, Zoldan K, Esser C, et al. Benzo(a)pyrene attenuates the pattern-recognition-receptor induced proinflammatory phenotype of murine macrophages by inducing IL-10 expression in an aryl hydrocarbon receptor-dependent manner. Toxicology. 2018;409:80-90 pubmed publisher
    ..the expression of major histocompatibility complex class II (MHC-II), CD14, Fcγ receptor I (FcγRI/CD64), or CD86, enhanced NO production and phagocytosis what may be beneficial for phagocytosis and killing of microbial pathogens...
  18. Meshkibaf S, Martins A, Henry G, Kim S. Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages. Cytokine. 2016;78:69-78 pubmed publisher
    ..3) and FIZZ1 (found in inflammatory zone 1), and lower levels of inducible nitric oxide synthase (iNOS), CD80 and CD86 than bone marrow-derived macrophages prepared in the presence of M-CSF alone (BMDM), in response to interleukin (IL)..
  19. Tang J, Yu W, Chen S, Gao Z, Xiao B. Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse. Neurochem Res. 2018;43:985-994 pubmed publisher
    ..At transcriptional level, M1 marker (inducible nitric oxide synthase (iNOS), CD16, CD86, CXCL10) in CSDS mice was higher than that in control group while there was no difference in M2 marker (Arginase ..
  20. Ragni M, Wu W, Liang X, Hsieh C, Cortese Hassett A, Lu L. Factor VIII-pulsed dendritic cells reduce anti-factor VIII antibody formation in the hemophilia A mouse model. Exp Hematol. 2009;37:744-54 pubmed publisher
    ..VIII-pulsed immature DCre (deficient nuclear factor-kappaB nuclear protein binding, low CD80, low CD86, high interleukin [IL]-10 phenotype) 7 days before rF.VIII challenge, anti-F...
  21. Hong R, Wang Z, Sui A, Liu X, Fan C, Lipkind S, et al. Gingival mesenchymal stem cells attenuate pro-inflammatory macrophages stimulated with oxidized low-density lipoprotein and modulate lipid metabolism. Arch Oral Biol. 2019;98:92-98 pubmed publisher
    ..with GMSCs, the M1 markers of Tumor Necrosis Factor (TNF) -α, Interleukin (IL) -6, Interleukin (IL) -1β, CD86, and Human Leukocyte Antigen (HLA) -DR were significantly reduced...
  22. Yao X, Dong G, Zhu Y, Yan F, Zhang H, Dai J, et al. [The activation of CD11b by leukadherin-1 alleviates endotoxic shock through promoting the aggregation and activation of myeloid-derived suppressor cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018;34:961-968 pubmed
    ..Flow cytometry was utilized to detect the ratio changes of MDSCs, G-MDSCs and M-MDSCs as well as the expression of CD86 and CD40 in macrophage, hematoxylin-eosin staining of lung and liver was utilized to detect the pathological injury,..
  23. Liu W, Lin Y, Spearman M, Cheng P, Butler M, Wu S. Influenza Virus Hemagglutinin Glycoproteins with Different N-Glycan Patterns Activate Dendritic Cells In Vitro. J Virol. 2016;90:6085-6096 pubmed publisher
    ..Significantly higher HLA-DR, CD40, CD83, and CD86 expression levels, as well reduced endocytotic capacity in human DCs, were noted in the high-mannose-type rH1HA and ..
  24. Kościuczuk E, Lisowski P, Jarczak J, Majewska A, Rzewuska M, Zwierzchowski L, et al. Transcriptome profiling of Staphylococci-infected cow mammary gland parenchyma. BMC Vet Res. 2017;13:161 pubmed publisher
    ..pathway (CCL2, CXCL5, HCK, CCR1), cell adhesion molecules (CAMs) pathway (BOLA-DQA2, BOLA-DQA1, F11R, ITGAL, CD86), antigen processing and presentation pathway (CD8A, PDIA3, LGMN, IFI30, HSPA1A), and NOD-like receptor signaling ..
  25. Sun J, Holmgren J, Larena M, Terrinoni M, Fang Y, Bresnick A, et al. Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin. Front Immunol. 2017;8:1119 pubmed publisher
    ..impaired responses in several CT-stimulated immune regulatory molecules including the co-stimulatory molecule CD86, inflammasome-associated caspase-1 and IL-1?...
  26. Jin B, Liu L, Zhang S, Cao X, Xu Y, Wang J, et al. Nuclear Magnetic Resonance-Assisted Metabolic Analysis of Plasma for Mild Gestational Diabetes Mellitus Patients. Metab Syndr Relat Disord. 2017;15:439-449 pubmed publisher
    ..The messenger RNA (mRNA) expression of CX3CL1, CD14, and CD86 in placenta and omental adipose tissues was detected by quantitative real-time polymerase chain reaction...
  27. Malachin G, Lubian E, Mancin F, Papini E, Tavano R. Combined Action of Human Commensal Bacteria and Amorphous Silica Nanoparticles on the Viability and Immune Responses of Dendritic Cells. Clin Vaccine Immunol. 2017;24: pubmed publisher
    ..The induction of maturation markers (CD86, CD80, CD83, intercellular adhesion molecule 1, and major histocompatibility complex class II) by commensal ..
  28. Wang F, Huang X, Chung C, Chen Y, HUTCHINS N, Ayala A. Contribution of programmed cell death receptor (PD)-1 to Kupffer cell dysfunction in murine polymicrobial sepsis. Am J Physiol Gastrointest Liver Physiol. 2016;311:G237-45 pubmed publisher
    ..markedly enhanced phagocytosis and restoration of the expression of major histocompatibility complex II and CD86, but reduced CD80 expression compared with septic wild-type (WT) mouse Kupffer cells...
  29. Nolfi A, Brown B, Liang R, Palcsey S, Bonidie M, Abramowitch S, et al. Host response to synthetic mesh in women with mesh complications. Am J Obstet Gynecol. 2016;215:206.e1-8 pubmed publisher
    ..vs M2 proremodeling phenotypes were examined via immunofluorescent labeling for cell surface markers CD86 (M1) vs CD206 (M2) and M1 vs M2 cytokines via enzyme-linked immunosorbent assay...
  30. Shi J, Wang M, Wan Y, Ikeda K. [The biological characteristics of peripheral blood CD123+ myeloid dendritic cell]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25:204-7 pubmed
    ..FACS analysis showed the high expression of CD86 and CD11C, moderate expression of CD1a and CD123, low levels of CD83 on DC after induction by GM-CSF and IL-4 for 7 ..
  31. Zhu H, Xu W, Liu H, Wang H, Fu R, Wu Y, et al. Expression of activated molecules on CD5(+)B lymphocytes in autoimmune hemolytic anemia. Int J Hematol. 2016;103:545-53 pubmed publisher
    ..The expression of CD80, CD86, and CD69 on CD5(+)B lymphocytes was detected using flow cytometry in 30 AIHA/Evans patients, 18 normal controls (..
  32. da Cunha A, Antoniazi Michelin M, Candido Murta E. Phenotypic profile of dendritic and T cells in the lymph node of Balb/C mice with breast cancer submitted to dendritic cells immunotherapy. Immunol Lett. 2016;177:25-37 pubmed publisher
    ..and inhibit the secretion of TGF-? and IL-10 in nodal lymph infiltrates, as well as co-stimulatory activating (CD86) and adhesion molecules in DCs and T cells LFA-1/ICAM-1 and inhibit the secretion of CTLA-4 present in lymph nodes...
  33. Kovacs B, Parry R, Ma Z, Fan E, Shivers D, Freiberg B, et al. Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells. J Immunol. 2005;175:7848-54 pubmed
    ..It has been postulated that a major role of costimulation is to facilitate LR aggregation. CD86 is up-regulated or expressed aberrantly on immune cells in a wide array of autoimmune and infectious diseases...
  34. Hayashi T, Yao S, Crain B, Promessi V, Shyu L, Sheng C, et al. Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes. PLoS ONE. 2015;10:e0129867 pubmed publisher
    ..this drug only modestly increased DC surface expression of activation markers such as MHC class II, CD80, and CD86; however, the expression of negative regulatory molecules, such as programmed death ligand 1 (PD-L1), and ..
  35. Wu W, Wang W, Wang Y, Li W, Yu G, Li Z, et al. IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings. Acta Biochim Biophys Sin (Shanghai). 2015;47:597-603 pubmed publisher
    ..It was found that IL-37b down-regulated the expressions of co-stimulatory molecules CD80 and CD86 on DCs in vitro...
  36. Muñoz S, Rodríguez L. Dendritic cells generated in the presence of vitamin D3 and stimulated with lipopolysaccharide secrete IL-8, IL-1?, IL-10 and induce relatively low levels of CD4+CD25hiFoxp3+ T cells. Biomedica. 2016;36:239-50 pubmed publisher
    ..When activated with LPS, they expressed lower levels of C83, CD83 and CD86; HLA-DR; higher amounts of IL-1?, IL-8, IL-10, and tended to lessen IL-6, IL-12p70 and TGF-?1, compared to DCs not ..
  37. Guadalupe Cabral M, Pereira M, Silva Z, Iria I, Coutinho C, Lopes A, et al. Using dendritic cells to evaluate how Burkholderia cenocepacia clonal isolates from a chronically infected cystic fibrosis patient subvert immune functions. Med Microbiol Immunol. 2017;206:111-123 pubmed publisher
    ..All infected DCs failed to upregulate maturation markers, HLA-DR, CD80, CD86 and CD83. Nevertheless, these infected DCs activated approximately twice more T cells than non-infected DCs...
  38. Planès R, BenMohamed L, Leghmari K, Delobel P, Izopet J, Bahraoui E. HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms. J Virol. 2014;88:6672-89 pubmed publisher
  39. Cheng S, Zhou H, Xie H, Kong X, Xie Y, He C, et al. [TLR4 promotes the activation of B cells in β2GP1-immunized mice]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31:1156-61 pubmed
    ..And the levels of co-stimulatory molecules CD80 and CD86 in the spleen were determined by flow cytometry...
  40. Su K, Watanabe A, Yeh C, Kelsoe G, Kuraoka M. Efficient Culture of Human Naive and Memory B Cells for Use as APCs. J Immunol. 2016;197:4163-4176 pubmed
    ..Significantly, proliferating CD B cells express high levels of MHC class II, CD80, and CD86. CD B cells act as APCs and present alloantigens and microbial Ags to T cells...
  41. Mendes M, Carvalho Costa T, da Silva M, Anhê A, Guimarães R, da Costa T, et al. Effect of the saliva from different triatomine species on the biology and immunity of TLR-4 ligand and Trypanosoma cruzi-stimulated dendritic cells. Parasit Vectors. 2016;9:634 pubmed
    ..Saliva differentially inhibited the expression of MHC-II, CD40, CD80 and CD86 in LPS-matured DCs. Except for the saliva of R...
  42. Schaedler E, Remy Ziller C, Hortelano J, Kehrer N, Claudepierre M, Gatard T, et al. Sequential administration of a MVA-based MUC1 cancer vaccine and the TLR9 ligand Litenimod (Li28) improves local immune defense against tumors. Vaccine. 2017;35:577-585 pubmed publisher
    ..Combination treatment augmented the number of activated CD86+ DCs in the draining lymph nodes and increased the percentage of KLRG1+ CD127-CD8<..
  43. Yu A, Neil S, Quandt J. High yield primary microglial cultures using granulocyte macrophage-colony stimulating factor from embryonic murine cerebral cortical tissue. J Neuroimmunol. 2017;307:53-62 pubmed publisher
    ..Microglial expression of CD45, CD11b, CD11c, MHC class I and II, CD40, CD80, and CD86 was analyzed by flow cytometry and compared to those isolated using different culture methods and to the BV-2 cell ..
  44. Yin W, Ouyang S, Luo Z, Zeng Q, Hu B, Xu L, et al. Immature Exosomes Derived from MicroRNA-146a Overexpressing Dendritic Cells Act as Antigen-Specific Therapy for Myasthenia Gravis. Inflammation. 2017;40:1460-1473 pubmed publisher
    ..Results showed that exosomes from microRNA-146a overexpressing DCs expressed decreased levels of CD80 and CD86. In experimental autoimmune MG, exosomes from microRNA-146a overexpressing DCs suppressed ongoing clinical MG in ..
  45. Richmond O, Cecere T, Erdogan E, Meng X, Piñeyro P, Subramaniam S, et al. The PD-L1/CD86 ratio is increased in dendritic cells co-infected with porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus, and the PD-L1/PD-1 axis is associated with anergy, apoptosis, and the induction of regulatory T-c. Vet Microbiol. 2015;180:223-9 pubmed publisher
    ..In this study, we evaluated the expression levels of PD-L1, CD86, and IL-10 in order to phenotype dendritic cells following viral infection with PCV2b and/or PRRSV...
  46. Vatankhah A, Halász J, Piurkó V, Barbai T, Rásó E, Tímár J. Characterization of the inflammatory cell infiltrate and expression of costimulatory molecules in chronic echinococcus granulosus infection of the human liver. BMC Infect Dis. 2015;15:530 pubmed publisher
    ..Furthermore, expression levels of costimulatory CTLA4, CD28, CD80 and CD86 molecules were measured at RNA level by PCR...
  47. Sobotta K, Hillarius K, Mager M, Kerner K, Heydel C, Menge C. Coxiella burnetii Infects Primary Bovine Macrophages and Limits Their Host Cell Response. Infect Immun. 2016;84:1722-1734 pubmed publisher
    ..release of IL-1β and vastly failed to stimulate increased expression of activation markers, such as CD40, CD80, CD86, and major histocompatibility complex (MHC) molecules...
  48. Meng C, Wang X, Xu Z, Hu M, Liu J, Pan Z, et al. Murine Flt3 ligand-generated plasmacytoid and conventional dendritic cells display functional differentiation in activation, inflammation, and antigen presentation during BCG infection in vitro. In Vitro Cell Dev Biol Anim. 2017;53:67-76 pubmed publisher
    ..The CD40, CD80, CD86, and MHC-II proteins were significantly upregulated in both FL-cDCs and -pDCs beginning at 4 h post-BCG exposure...
  49. Loughland J, Minigo G, Sarovich D, Field M, Tipping P, Montes De Oca M, et al. Plasmacytoid dendritic cells appear inactive during sub-microscopic Plasmodium falciparum blood-stage infection, yet retain their ability to respond to TLR stimulation. Sci Rep. 2017;7:2596 pubmed publisher
    ..07). There was no upregulation of co-stimulatory molecules CD86, CD80, CD40, and reduced surface expression of HLA-DR and CD123 (IL-3R-α)...
  50. Armas González E, Díaz Martín A, Domínguez Luis M, Arce Franco M, Herrera García A, Hernández Hernández M, et al. Differential Antigen-presenting B Cell Phenotypes from Synovial Microenvironment of Patients with Rheumatoid and Psoriatic Arthritis. J Rheumatol. 2015;42:1825-34 pubmed publisher
    ..The presence of HLA-DR, CD86, and CD40 in CD20+ cells was studied in RA synovium biopsies using immunohistochemistry and immunofluorescence...
  51. Smith T, Tse M, Read E, Liu W. Regulation of macrophage polarization and plasticity by complex activation signals. Integr Biol (Camb). 2016;8:946-55 pubmed publisher
    ..of LPS, IFN-γ, IL-4, and IL-13 acquire a mixed activation state, with individual cells expressing both M1 marker CD86 and M2 marker CD206 instead of polarizing to discrete phenotypes...
  52. Ghadge S, Messner M, Van Pham T, Doppelhammer M, Petry A, Gorlach A, et al. Prolyl-hydroxylase inhibition induces SDF-1 associated with increased CXCR4+/CD11b+ subpopulations and cardiac repair. J Mol Med (Berl). 2017;95:825-837 pubmed publisher
    ..upregulated reparative M2 like CXCR4-EGFP+ CD11b+/CD206+ cells compared to inflammatory M2-like CXCR4-EGFP+ CD11b+/CD86+ cells associated with reduced apoptotic cell death, increased neovascularization, reduced scar size, and an ..
  53. Chang T, Kuchroo V, Sharpe A. Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. Curr Dir Autoimmun. 2002;5:113-30 pubmed
  54. Sun C, Luo Q, Lu X, Zheng D, He D, Wu Z. [Isolation and purification of primary Kupffer cells from mouse liver]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:1021-5 pubmed
    ..molecules associated with antigen presentation, including major histocompatibility complex class II (MHC II), CD40, CD86 and CD68 on the surface of KCs subjected to hypoxia/reoxygenation (H/R) modeling...
  55. Smith M, Rihanek M, Coleman B, Gottlieb P, Sarapura V, Cambier J. Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients. J Autoimmun. 2018;89:82-89 pubmed publisher
    ..in recent onset patients thyroid antigen-reactive B cells in blood no longer appear anergic, rather they express CD86, a marker of activation...
  56. Watanabe R, Harada Y, Takeda K, Takahashi J, Ohnuki K, Ogawa S, et al. Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation. J Immunol. 2006;177:1085-91 pubmed
    ..Our data suggest that, in addition to the PI3K binding motif, the PXXP motif in the CD28 cytoplasmic domain may also define a functional difference between the CD28- and ICOS-mediated costimulatory signals by binding to Gads. ..
  57. Wang L, Li Z, Ciric B, Safavi F, Zhang G, Rostami A. Selective depletion of CD11c+ CD11b+ dendritic cells partially abrogates tolerogenic effects of intravenous MOG in murine EAE. Eur J Immunol. 2016;46:2454-2466 pubmed publisher
    ..dendritic cells (DCs) with an immature phenotype having low expression of IA and co-stimulatory molecules CD40, CD86, and CD80. Here, we further investigate the role of tolerogenic DCs in i.v...
  58. Guo K, Sun X, Gu Y, Wang Z, Huang J, Zhu X. Trichinella spiralis paramyosin activates mouse bone marrow-derived dendritic cells and induces regulatory T cells. Parasit Vectors. 2016;9:569 pubmed
    ..Maturation of DC was determined by the expression of surface markers CD40, CD80, CD86 and MHCII. The rTsPmy-pulsed DCs were co-incubated with T...
  59. Hewing B, Au S, Ludwig A, Ellerbroek R, van Dijck P, Hartmann L, et al. Severe Aortic Valve Stenosis in Adults is Associated with Increased Levels of Circulating Intermediate Monocytes. J Cardiovasc Transl Res. 2017;10:27-34 pubmed publisher
    ..Classical (CD14++CD16-), intermediate (CD14++CD16+), and non-classical (CD14+CD16++) CD86-positive monocytes and monocyte activation (intensity of CD11b expression) were determined by flow cytometry in ..
  60. Talamonti E, Pauter A, Asadi A, Fischer A, Chiurchiù V, Jacobsson A. Impairment of systemic DHA synthesis affects macrophage plasticity and polarization: implications for DHA supplementation during inflammation. Cell Mol Life Sci. 2017;74:2815-2826 pubmed publisher
    ..macrophages, M1 cells derived from Elovl2-/- mice showed an increased expression of key markers (iNOS, CD86 and MARCO) and cytokines (IL-6, IL-12 and IL-23)...
  61. Kuo R, Saito E, Miller S, Shea L. Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression and T Cell Activity to Induce Tolerance. Mol Ther. 2017;25:1676-1685 pubmed publisher
    ..cells expressing MHC-restricted antigen revealed most significant decreases in positive co-stimulatory molecules (CD86, CD80, and CD40) following high doses of nanoparticles with higher peptide conjugation, whereas expression of a ..
  62. Brodaczewska K, Wolaniuk N, Lewandowska K, Donskow Łysoniewska K, Doligalska M. Biodegradable Chitosan Decreases the Immune Response to Trichinella spiralis in Mice. Molecules. 2017;22: pubmed publisher
    ..infiltration into the peritoneal cavity of CD11b⁺ cells, with reduced expression of MHC class II, CD80, CD86, Dectin-1 or CD23 receptors in comparison to T. spiralis-infected mice...
  63. Oussa N, Dahmani A, Gomis M, Richaud M, Andreev E, Navab Daneshmand A, et al. VEGF Requires the Receptor NRP-1 To Inhibit Lipopolysaccharide-Dependent Dendritic Cell Maturation. J Immunol. 2016;197:3927-3935 pubmed
    ..signaling through ERK and NF-??, resulting in a sharp inhibition of MHC class II and costimulatory molecules (CD40, CD86) expression as well as proinflammatory cytokine production...
  64. Vang K, Safina I, Darrigues E, Nedosekin D, Nima Z, Majeed W, et al. Modifying Dendritic Cell Activation with Plasmonic Nano Vectors. Sci Rep. 2017;7:5513 pubmed publisher
    ..e. CD40, CD86, and MHC class II...
  65. van Ham M, Teich R, Philipsen L, Niemz J, Amsberg N, Wissing J, et al. TCR signalling network organization at the immunological synapses of murine regulatory T cells. Eur J Immunol. 2017;47:2043-2058 pubmed publisher
    ..recruitment of TCR signalling components such as PKCθ, PLCγ1 and ZAP70 as well as B cell-derived CD86 into the IS...
  66. Li Y, Yu Q, Zhao W, Zhang J, Liu W, Huang M, et al. Oligomeric proanthocyanidins attenuate airway inflammation in asthma by inhibiting dendritic cells maturation. Mol Immunol. 2017;91:209-217 pubmed publisher
    ..The expression of co-stimulatory molecules especially CD86 distributed on pulmonary DCs and bone marrow-derived DCs (BMDCs) also markedly declined...
  67. Huang Y, Wang Z, Zheng Q, Tang J, Cai J, Lu Y, et al. Conservation of structural and interactional features of CD28 and CD80/86 molecules from Nile tilapia (Oreochromis niloticus). Fish Shellfish Immunol. 2018;72:95-103 pubmed publisher
    Interaction of CD28 with CD80 or CD86 molecules provides a costimulatory signals required in T cell activation...
  68. Yang Z, Liu Y, Zhou X. Immune modulation by silencing CD80 and CD86 production in dendritic cells using small hairpin RNA to reduce heart transplant rejection. Transpl Immunol. 2018;49:20-27 pubmed publisher
    ..shRNA targeting on the cluster of differentiation 80 (CD80, B7-1) and the cluster of differentiation 86 (CD86, B7-2) and transfected it into dendritic cells (DCs)...
  69. Zheng J, Liang H, Xu C, Xu Q, Zhang T, Shen T, et al. An unbalanced PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes is correlated with HCV viremia during chronic HCV infection. Cell Mol Immunol. 2014;11:294-304 pubmed publisher
    ..PD-L1 expression and the PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes were higher during chronic HCV infection than in spontaneous HCV resolvers and ..
  70. Jeffery L, Qureshi O, Gardner D, Hou T, Briggs Z, Soskic B, et al. Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function. PLoS ONE. 2015;10:e0131539 pubmed publisher
    ..is known regarding factors that regulate CTLA-4 expression and their effect upon its function to remove CD80 and CD86 from antigen presenting cells by transendocytosis...
  71. Inoue T, Ikegame K, Kaida K, Okada M, Yoshihara S, Tamaki H, et al. Host Foxp3+CD4+ Regulatory T Cells Act as a Negative Regulator of Dendritic Cells in the Peritransplantation Period. J Immunol. 2016;196:469-83 pubmed publisher
    ..closely contacted with host dendritic cells (DCs), and significantly restrained the maturation (CD80 and CD86 expression) of DCs in a dose-dependent manner...
  72. Cao Y, Wang Q, Du Y, Liu F, Zhang Y, Feng Y, et al. l-arginine and docetaxel synergistically enhance anti-tumor immunity by modifying the immune status of tumor-bearing mice. Int Immunopharmacol. 2016;35:7-14 pubmed publisher
    ..pDCs) dendritic cells, potent activators of the T cell response, and enhanced expression of the maturation markers CD86 and MHC II (required for antigen presentation). The combination therapy also reduced the proliferation of MDSCs...
  73. Xu L, Xia M, Guo J, Sun X, Li H, Xu C, et al. Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism Fc?RIIB-T232. J Exp Med. 2016;213:2707-2727 pubmed
    ..Moreover, substituting the Fc?RIIB-T232 TM domain with that of a fast floating CD86 molecule restored both the rapid mobility and the inhibitory function, which further corroborated the importance of ..
  74. Liu C, Jiang J, Wang T, Liu X, Gao L, Zhu R, et al. CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China. Genet Mol Res. 2013;12:1373-82 pubmed publisher
    The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes are important susceptibility genes associated with autoimmune diseases...
  75. Basbous S, Levescot A, Piccirilli N, Brizard F, Guilhot F, Roy L, et al. The Rho-ROCK pathway as a new pathological mechanism of innate immune subversion in chronic myeloid leukaemia. J Pathol. 2016;240:262-268 pubmed publisher
    ..of CD1d could not be ascribed to defective mDC differentiation, as attested by normal expression of HLA-DR and the CD86 maturation marker...
  76. Ozkazanç D, Yoyen Ermis D, Tavukcuoglu E, Buyukasik Y, Esendagli G. Functional exhaustion of CD4+ T cells induced by co-stimulatory signals from myeloid leukaemia cells. Immunology. 2016;149:460-471 pubmed publisher
    ..Here, CD86 and inducible T-cell co-stimulator ligand (ICOS-LG) co-stimulatory molecules that are found on myeloid leukaemia ..
  77. Wijesundara D, Yu W, Quah B, Eldi P, Hayball J, Diener K, et al. Cytolytic DNA vaccine encoding lytic perforin augments the maturation of- and antigen presentation by- dendritic cells in a time-dependent manner. Sci Rep. 2017;7:8530 pubmed publisher
    ..to purified DCs from naïve C57BL/6 mice resulted in maturation of DCs as determined by up-regulation of CD80/CD86. Using activation/proliferation of adoptively transferred OT-I CD8+ T cells to measure antigen ..
  78. Bai Y, Ning Y, Zhou H, Qi C. [Whole glucan particle promotes the maturation of tumor-educated mouse dendritic cells to suppress regulatory T cell differentiation]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1171-1176 pubmed
    ..Expressions of cell surface markers (CD11c, CD86, CD40, CD80, MHC-II) and CD4+ FOXP3+T cell differentiation and proliferation were detected by ..
  79. Wang Q, He H, Chen D, Wang C, Xu Y, Song W. Hepatic stroma-educated regulatory DCs suppress CD8+ T cell proliferation in mice. Oncotarget. 2017;8:93414-93425 pubmed publisher
    ..mature DCs incubated with liver stromal cells were characterized by a longer life span, reduced CD11c, IA/IE, CD80, CD86, and CD40 expression, and increased CD11b expression...
  80. Jellis C, Wang S, Rennert P, Borriello F, Sharpe A, Green N, et al. Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86). Immunogenetics. 1995;42:85-9 pubmed
    ..2 (CD86) to TCR antigen CD28...
  81. Verbovetski I, Bychkov H, Trahtemberg U, Shapira I, Hareuveni M, Ben Tal O, et al. Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7. J Exp Med. 2002;196:1553-61 pubmed
    ..iC3b-opsonized apoptotic cells and iDCs down-regulated the expression of major histocompatibility complex class II, CD86, CC chemokine receptor (CCR)2, CCR5, and beta2-integrins (P < 0...
  82. Gold M, Donnelly E, Cook M, Leclair C, Lewinsohn D. Purified neonatal plasmacytoid dendritic cells overcome intrinsic maturation defect with TLR agonist stimulation. Pediatr Res. 2006;60:34-7 pubmed
    ..While purified CD123+ plasmacytoid dendritic cells from adults up-regulated co-stimulatory molecules CD80 and CD86 with IL-3 alone those from neonates required the addition of CpG-DNA to reach adult levels...
  83. Nukada Y, Ito Y, Miyazawa M, Sakaguchi H, Nishiyama N. The relationship between CD86 and CD54 protein expression and cytotoxicity following stimulation with contact allergen in THP-1 cells. J Toxicol Sci. 2011;36:313-24 pubmed
    ..Altogether, these results suggest that cytotoxicity induced by contact allergens may result in apoptosis and may also be stimulated in parallel with protein expression through an intracellular signal or signals...
  84. Satoorian T, Li B, Tang X, Xiao J, Xing W, Shi W, et al. MicroRNA223 promotes pathogenic T-cell development and autoimmune inflammation in central nervous system in mice. Immunology. 2016;148:326-38 pubmed publisher
    ..Expression of the genes associated with dendritic cell (DC) activation (CD86 and MHC II) and Th1 and Th17 differentiation [interleukin-12 (IL-12) and IL-23, respectively] was significantly ..
  85. Song L, Ma A, Dun H, Hu Y, Fujii Y, Kinugasa F, et al. ASP2409, A Next-Generation CTLA4-Ig, Versus Belatacept in Renal Allograft Survival in Cynomolgus Monkeys. Am J Transplant. 2017;17:635-645 pubmed publisher
    ..study, ASP2409, a new cytotoxic T-lymphocyte associated protein 4-immunoglobulin possessing 14-fold higher in vitro CD86 binding affinity than belatacept, was tested for renal allograft survival in cynomolgus monkeys...
  86. Sun X, Wang J, Zhou J, Wang H, Wang X, Wu J, et al. Subcutaneous immunization with Streptococcus pneumoniae GAPDH confers effective protection in mice via TLR2 and TLR4. Mol Immunol. 2017;83:1-12 pubmed publisher
    ..experiments, rGAPDH induced phenotypic and functional maturation of BMDCs, because the high expression of CD40, CD86 and MHC II and the production of IL-12p70, IL-6 and TNF-α were observed after treatment with rGAPDH...
  87. Sacchi A, Tumino N, Turchi F, Refolo G, Fimia G, Ciccosanti F, et al. Dendritic cells activation is associated with sustained virological response to telaprevir treatment of HCV-infected patients. Clin Immunol. 2017;183:82-90 pubmed publisher
    ..Moreover, an up-regulation of CD80 and CD86 on mDC was observed in SVR patients as well as an improvement of IFN-? production by plasmacytoid DC, able to ..
  88. Tremblay McLean A, Bruneau J, Lebouché B, Lisovsky I, Song R, Bernard N. Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4? T Cells. Viruses. 2017;9: pubmed publisher
    ..ULBP-1), ULBP-2/5/6, ULBP-3, major histocompatibility complex (MHC) class 1-related (MIC)-A, MIC-B, CD48, CD80, CD86, CD112, CD155, Intercellular adhesion molecule (ICAM)-1, ICAM-2, HLA-E, HLA-F, HLA-A2, HLA-C, and the ligands to ..
  89. Yu H, Li H, Li Y, Li M, Chen G. Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice. Arch Dermatol Res. 2017;309:805-813 pubmed publisher
    ..In a human monocyte model THP-1, ISLG suppressed the up-regulation of CD86 and CD54 and abolished the DNCB-induced p38-? and ERK activation, suggesting a molecular mechanism for ISLG therapy...
  90. Ji Y, Lin S, Wang Y, Su M, Zhang W, Gunosewoyo H, et al. Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors. Eur J Med Chem. 2017;141:101-112 pubmed publisher
    ..These compounds activated CD86 expression on the human MV4-11 AML cells following 10 days of exposure, accompanied with the apparent cytotoxicity...
  91. Gülden E, Vudattu N, Deng S, Preston Hurlburt P, Mamula M, Reed J, et al. Microbiota control immune regulation in humanized mice. JCI Insight. 2017;2: pubmed publisher
    ..treatment affected CD11b+CD11c+ cells, which produced less IL-10 and IL-27, and showed increased expression of CD86 and activation of T cells when cocultured with T cells and teplizumab...
  92. Chen S, Lu Z, Wang F, Wang Y. Cathelicidin-WA polarizes E. coli K88-induced M1 macrophage to M2-like macrophage in RAW264.7 cells. Int Immunopharmacol. 2018;54:52-59 pubmed publisher
    ..Double staining of M1-specific CD86 and M2-specific CD206 also proved the hypothesis...