Gene Symbol: CD74
Description: CD74 molecule
Alias: DHLAG, HLADG, Ia-GAMMA, HLA class II histocompatibility antigen gamma chain, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), CD74 molecule, major histocompatibility complex, class II invariant chain, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, Ia-associated invariant chain, MHC HLA-DR gamma chain, gamma chain of class II antigens, p33
Species: human
Products:     CD74

Top Publications

  1. Bakke O, Dobberstein B. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell. 1990;63:707-16 pubmed
    ..As Ii is intracellularly associated with the MHC class II molecules, it is proposed that Ii determines the intracellular transport route of these molecules. ..
  2. Ghosh P, Amaya M, Mellins E, Wiley D. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature. 1995;378:457-62 pubmed
    ..The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM. ..
  3. Naujokas M, Morin M, Anderson M, Peterson M, Miller J. The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44. Cell. 1993;74:257-68 pubmed
    ..Antibody blocking studies and the ability of CD44 to bind directly to Ii-CS suggest that Ii-CS can function as an accessory molecule during T cell responses through interactions with CD44. ..
  4. Roche P, Teletski C, Stang E, Bakke O, Long E. Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization. Proc Natl Acad Sci U S A. 1993;90:8581-5 pubmed
    ..This pathway may represent an important mechanism for loading class II molecules with immunogenic peptides from several endocytic compartments. ..
  5. Datta M, Shahsafaei A, Nadler L, Freeman G, Dorfman D. Expression of MHC class II-associated invariant chain (Ii;CD74) in thymic epithelial neoplasms. Appl Immunohistochem Mol Morphol. 2000;8:210-5 pubmed
    ..In these cells, MHC class II-associated invariant chain (CD74) is involved in antigen presentation during T-cell selection...
  6. Stumptner Cuvelette P, Morchoisne S, Dugast M, Le Gall S, Raposo G, Schwartz O, et al. HIV-1 Nef impairs MHC class II antigen presentation and surface expression. Proc Natl Acad Sci U S A. 2001;98:12144-9 pubmed
    ..Cooperation between those mechanisms may enable Nef to efficiently inhibit MHC II function. ..
  7. Schindler M, Würfl S, Benaroch P, Greenough T, Daniels R, Easterbrook P, et al. Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J Virol. 2003;77:10548-56 pubmed
    ..Overall, our results suggest that the ability of Nef to interfere with MHC-II antigen presentation might play a role in AIDS pathogenesis. ..
  8. Burton J, Ely S, Reddy P, Stein R, Gold D, Cardillo T, et al. CD74 is expressed by multiple myeloma and is a promising target for therapy. Clin Cancer Res. 2004;10:6606-11 pubmed
    b>CD74 (HLA-DR-associated invariant chain) plays a role in antigen presentation. In addition to its expression on antigen-presenting cells, it is expressed by carcinomas of renal, lung, gastric, and thymic origin and by certain sarcomas...
  9. Becker Herman S, Arie G, Medvedovsky H, Kerem A, Shachar I. CD74 is a member of the regulated intramembrane proteolysis-processed protein family. Mol Biol Cell. 2005;16:5061-9 pubmed
    ..The MHC class II chaperone, CD74 (invariant chain, Ii), was previously shown to function as a signaling molecule in several pathways...

More Information

Publications113 found, 100 shown here

  1. Shi X, Leng L, Wang T, Wang W, Du X, Li J, et al. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity. 2006;25:595-606 pubmed
    The macrophage migration inhibitory factor (MIF) receptor (CD74) was cloned recently, but the signaling mechanism is not evident...
  2. Kirchhoff F, Schindler M, Specht A, Arhel N, Munch J. Role of Nef in primate lentiviral immunopathogenesis. Cell Mol Life Sci. 2008;65:2621-36 pubmed publisher
    ..This evolutionary loss of a specific Nef function may contribute to the high virulence of HIV-1 in humans. ..
  3. McClelland M, Zhao L, Carskadon S, Arenberg D. Expression of CD74, the receptor for macrophage migration inhibitory factor, in non-small cell lung cancer. Am J Pathol. 2009;174:638-46 pubmed publisher
    ..The MIF receptor was recently discovered and found to be the invariant chain of the HLA class II molecule, CD74. We hypothesized that the expression of this receptor-ligand pair in lung cancer is associated with the angiogenic ..
  4. Specht A, Telenti A, Martinez R, Fellay J, Bailes E, Evans D, et al. Counteraction of HLA-C-mediated immune control of HIV-1 by Nef. J Virol. 2010;84:7300-11 pubmed publisher
    ..Thus, while high HLA-C expression may generally facilitate control of HIV-1, Nef may counteract HLA-C-mediated immune control in some individuals indirectly, by manipulating T-cell function and MHC-II antigen presentation. ..
  5. Shachar I, Haran M. The secret second life of an innocent chaperone: the story of CD74 and B cell/chronic lymphocytic leukemia cell survival. Leuk Lymphoma. 2011;52:1446-54 pubmed publisher
    This review deals with the cytokine macrophage migration inhibitory factor (MIF) and its receptor, CD74. MIF and CD74 have been shown to regulate peripheral B cell survival and were associated with tumor progression and metastasis...
  6. Greenwood C, Metodieva G, Al Janabi K, Lausen B, Alldridge L, Leng L, et al. Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer. J Proteomics. 2012;75:3031-40 pubmed publisher
    ..The first is characterized by high expression of Stat1, Mx1, and CD74. Seven out of 9 tumors from this group had invaded at least 2 lymph nodes while only 1 out of 10 tumors in group 2 ..
  7. Metodieva G, Nogueira de Souza N, Greenwood C, Al Janabi K, Leng L, Bucala R, et al. CD74-dependent deregulation of the tumor suppressor scribble in human epithelial and breast cancer cells. Neoplasia. 2013;15:660-8 pubmed
    The ? subunit of the major histocompatibility complex (MHC) class II complex, CD74, is overexpressed in a significant proportion of metastatic breast tumors, but the mechanistic foundation and biologic significance of this phenomenon are ..
  8. Jasanoff A, Wagner G, Wiley D. Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii. EMBO J. 1998;17:6812-8 pubmed
    ..The cylindrical shape of the molecule and the mapping of conserved residues delimit surfaces which may be important for interactions between Ii and class II molecules. ..
  9. Leng L, Metz C, Fang Y, Xu J, Donnelly S, Baugh J, et al. MIF signal transduction initiated by binding to CD74. J Exp Med. 2003;197:1467-76 pubmed
    ..Using expression cloning and functional analysis, we report herein that CD74, a Type II transmembrane protein, is a high-affinity binding protein for MIF...
  10. Barrilleaux B, Fischer Valuck B, Gilliam J, Phinney D, O Connor K. Activation of CD74 inhibits migration of human mesenchymal stem cells. In Vitro Cell Dev Biol Anim. 2010;46:566-72 pubmed publisher
    ..targets, an activating antibody (CD74Ab) was employed in this study to examine the effect of one MIF receptor, CD74 (major histocompatibility complex class II-associated invariant chain), on MSC motility...
  11. Binsky I, Lantner F, Grabovsky V, Harpaz N, Shvidel L, Berrebi A, et al. TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner. J Immunol. 2010;184:4761-9 pubmed publisher
    ..b>CD74 was recently shown to serve as a survival receptor on CLL cells...
  12. Tian B, Zhang Y, Li N, Liu X, Dong J. CD74: a potential novel target for triple-negative breast cancer. Tumour Biol. 2012;33:2273-7 pubmed publisher
    The expression status of CD74 in breast cancer stem cells and its clinical implications was evaluated in order to lay a foundation for managing breast cancer. Five hundred and eighty breast cancer specimens were enrolled in the study...
  13. Li J, Tang Y, Tang P, Lv J, Huang X, Carlsson Skwirut C, et al. Blocking Macrophage Migration Inhibitory Factor Protects Against Cisplatin-Induced Acute Kidney Injury in Mice. Mol Ther. 2018;26:2523-2532 pubmed publisher
    ..found that both genetic knockout and pharmacological inhibition of MIF protected against AKI by inactivating the CD74-nuclear factor κB (NF-κB) signaling. In conclusion, MIF is pathogenic in cisplatin-induced AKI...
  14. Fader K, Nault R, Ammendolia D, Harkema J, Williams K, Crawford R, et al. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice. Toxicol Sci. 2015;148:567-80 pubmed publisher
    ..Moreover, several major histocompatibility complex (MHC) class II genes (H2-Aa, H2-Ab1, H2-DMb1, Cd74) were repressed, coincident with decreased macrophage and dendritic cell levels in the lamina propria, suggesting ..
  15. Nagata Y, Yoshihisa Y, Matsunaga K, Rehman M, Kitaichi N, Kitaichi N, et al. Role of macrophage migration inhibitory factor (MIF) in pollen-induced allergic conjunctivitis and pollen dermatitis in mice. PLoS ONE. 2015;10:e0115593 pubmed publisher
    ..This eotaxin expression was inhibited by the treatment with CD74 siRNA in fibroblasts...
  16. Sun H, Zhang X, Zhao L, Zhen X, Huang S, Wang S, et al. Attenuation of atherosclerotic lesions in diabetic apolipoprotein E-deficient mice using gene silencing of macrophage migration inhibitory factor. J Cell Mol Med. 2015;19:836-49 pubmed publisher
    ..An increased expression of MIF and its ligand CD74 was also detected in the diabetic patients with coronary artery disease...
  17. Yang H, Zheng S, Mao Y, Chen Z, Zheng C, Li H, et al. Modulating of ocular inflammation with macrophage migration inhibitory factor is associated with notch signalling in experimental autoimmune uveitis. Clin Exp Immunol. 2016;183:280-93 pubmed publisher
    ..We found that the expression of MIF and its two receptors CD74 and CD44 was increased in the EAU mouse retina. Compared to AAV8.CBA...
  18. Heinrichs D, Berres M, Coeuru M, Knauel M, Nellen A, Fischer P, et al. Protective role of macrophage migration inhibitory factor in nonalcoholic steatohepatitis. FASEB J. 2014;28:5136-47 pubmed publisher
    ..Blockade of MIF receptor cluster of differentiation 74 (CD74) but not of CXCR2 or CXCR4 fully reverted the protective effect of MIF, comparable to AMPK inhibition...
  19. Bozza M, Lintomen L, Kitoko J, Paiva C, Olsen P. The Role of MIF on Eosinophil Biology and Eosinophilic Inflammation. Clin Rev Allergy Immunol. 2019;: pubmed publisher
    ..CD4+ T cells and eosinophils express CD74 and CXCR4, receptors able to signal upon MIF binding...
  20. Klymenko T, Gu Q, Herbert I, Stevenson A, Iliev V, Watkins G, et al. RNA-Seq Analysis of Differentiated Keratinocytes Reveals a Massive Response to Late Events during Human Papillomavirus 16 Infection, Including Loss of Epithelial Barrier Function. J Virol. 2017;91: pubmed publisher
    ..I interferon regulator IRF1, kappa interferon (IFN-κ), and viral restriction factors (IFIT1, -2, -3, and -5, OASL, CD74, and RTP4) were upregulated...
  21. Wang J, Ye Q, Xu J, Benedek G, Zhang H, Yang Y, et al. DR?1-MOG-35-55 Reduces Permanent Ischemic Brain Injury. Transl Stroke Res. 2017;8:284-293 pubmed publisher
    ..T cells and block binding of the cytokine/chemokine macrophage migration inhibitory factor (MIF) to its CD74 receptor on monocytes and macrophages...
  22. Lessard M, Blais M, Beaudoin F, Deschene K, Verso L, Bissonnette N, et al. Piglet weight gain during the first two weeks of lactation influences the immune system development. Vet Immunol Immunopathol. 2018;206:25-34 pubmed publisher
    ..Gene analysis by Q-PCR confirmed microarray results and revealed that IL-10, SOD1, NOS2, NOD2, TLR4, TLR9, CD40 and CD74 expressions were significantly decreased (P < 0...
  23. Zhang M, Yan L, Kim J. Modulating mammary tumor growth, metastasis and immunosuppression by siRNA-induced MIF reduction in tumor microenvironment. Cancer Gene Ther. 2015;22:463-74 pubmed publisher
    ..MIF reduction in tumor-associated macrophages resulted in a significant reduction of surface expression of CD74 and CD206 and a significant increase of surface expression of major histocompatibility complex II, as well as ..
  24. Fernandez Jimenez N, Sklias A, Ecsedi S, Cahais V, Degli Esposti D, Jay A, et al. Lowly methylated region analysis identifies EBF1 as a potential epigenetic modifier in breast cancer. Epigenetics. 2017;:1-9 pubmed publisher
    ..EBF1 motifs showed a strong negative correlation with the expression of 719 nearby genes, including BTS2 and CD74, two oncogenes known to be specific for basal BC subtype and for poor outcome...
  25. Piton N, Ruminy P, Gravet C, Marchand V, Colasse É, Lamy A, et al. Ligation-dependent RT-PCR: a new specific and low-cost technique to detect ALK, ROS, and RET rearrangements in lung adenocarcinoma. Lab Invest. 2017;: pubmed publisher the ALK cases (gene partner: EML4 in all cases), 9 rearrangements (64%) in the ROS1 cases (gene partners: CD74 in 8 cases and SLC34A2 in 1 case) and 1 (100%) in the single RET case (gene partner: KIF5B)...
  26. Dobson S, Augustijn K, Brannigan J, Schnick C, Janse C, Dodson E, et al. The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei. Protein Sci. 2009;18:2578-91 pubmed publisher
    ..Finally, we show in pull-down assays that Plasmodium MIF binds to the cell surface receptor CD74, a known mammalian MIF receptor implying that parasite MIF has the ability to interfere with, or modulate, host MIF ..
  27. Adzavon Y, Zhao P, Lv B, Liu M, Zhang X, Xie F, et al. TLR7 and TLR8 agonist resiquimod (R848) differently regulates MIF expression in cells and organs. Cytokine. 2017;97:156-166 pubmed publisher
    ..enhanced cells ability to release soluble MIF and differently regulated mRNA expression of MIF-related receptors (CD74, CXCR4, CXCR2 and CD44)...
  28. Abdul Aziz A, Shafat M, Mehta T, Di Palma F, Lawes M, Rushworth S, et al. MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia. Cancer Res. 2017;77:303-311 pubmed publisher
    ..Recombinant MIF increased IL8 expression in BM-MSCs via its receptor CD74. Moreover, the MIF inhibitor ISO-1 inhibited AML-induced IL8 expression by BM-MSCs as well as BM-MSC-induced AML ..
  29. Spiro R, Quaranta V. The invariant chain is a phosphorylated subunit of class II molecules. J Immunol. 1989;143:2589-94 pubmed
    ..Phosphorylation may be another mechanism by which the functions of invariant chain in class II-dependent immune responses are regulated. ..
  30. Zeiner P, Zinke J, Kowalewski D, Bernatz S, Tichy J, Ronellenfitsch M, et al. CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival. Acta Neuropathol Commun. 2018;6:18 pubmed publisher
    ..We present data on the HLA class II-chaperone molecule CD74 in brain metastases and its impact on the HLA peptidome complexity...
  31. Matoba K, Iizuka N, Gondo T, Ishihara T, Yamada Okabe H, Tamesa T, et al. Tumor HLA-DR expression linked to early intrahepatic recurrence of hepatocellular carcinoma. Int J Cancer. 2005;115:231-40 pubmed
    ..Multivariate analysis showed that tumor HLA-DR protein expression was one of the independent risk factors for early IHR, suggesting HLA-DR protein potential as a biomarker and a molecular target for therapeutic intervention. ..
  32. Gupta S, Kloster M, Rodionov D, Bakke O. Re-routing of the invariant chain to the direct sorting pathway by introduction of an AP3-binding motif from LIMP II. Eur J Cell Biol. 2006;85:457-67 pubmed
  33. Subbannayya T, Variar P, Advani J, Nair B, Shankar S, Gowda H, et al. An integrated signal transduction network of macrophage migration inhibitory factor. J Cell Commun Signal. 2016;10:165-70 pubmed publisher
    ..MIF mediates its actions through a cell surface class II major histocompatibility chaperone, CD74 and co-receptors such as CD44, CXCR2, CXCR4 or CXCR7...
  34. Schneppenheim J, Loock A, Hüttl S, Schweizer M, Lüllmann Rauch R, Oberg H, et al. The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments. J Immunol. 2017;199:172-185 pubmed publisher
    The invariant chain (CD74) mediates assembly and targeting of MHC class II (MHCII) complexes...
  35. Kok T, Wasiel A, Dekker F, Poelarends G, Cool R. High yield production of human invariant chain CD74 constructs fused to solubility-enhancing peptides and characterization of their MIF-binding capacities. Protein Expr Purif. 2018;148:46-53 pubmed publisher
    The HLA class II histocompatibility antigen gamma chain, also known as HLA-DR antigen-associated invariant chain or CD74, has been shown to be involved in many biological processes amongst which antigen loading and transport of MHC class ..
  36. Sanderson F, Thomas C, Neefjes J, Trowsdale J. Association between HLA-DM and HLA-DR in vivo. Immunity. 1996;4:87-96 pubmed
    ..The additional N-linked glycan on mutant DR3 molecules isolated from the 10.24.6 cell line, which interferes with DM-enhanced CLIP release from DR3 in vitro, also affects the DM-DR interaction. ..
  37. Gold D, Stein R, Burton J, Goldenberg D. Enhanced expression of CD74 in gastrointestinal cancers and benign tissues. Int J Clin Exp Pathol. 2010;4:1-12 pubmed
    b>CD74, a transmembrane glycoprotein that associates with MHC II, is an important chaperone that regulates antigen presentation for immune response...
  38. Benedek G, Meza Romero R, Jordan K, Zhang Y, Nguyen H, Kent G, et al. MIF and D-DT are potential disease severity modifiers in male MS subjects. Proc Natl Acad Sci U S A. 2017;114:E8421-E8429 pubmed publisher
    ..migration inhibitory factor (MIF), its homolog D-dopachrome tautomerase (D-DT), and their common receptor CD74 may contribute to disease worsening...
  39. Keppler O, Tibroni N, Venzke S, Rauch S, Fackler O. Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1. J Leukoc Biol. 2006;79:616-27 pubmed
    ..In contrast, Nef markedly up-regulated cell surface levels of the MHC-II invariant chain CD74. The effect of Nef on these three surface receptors was also detected upon HIV-1 infection of activated primary CD4+..
  40. Zuo J, Thomas W, Haigh T, Fitzsimmons L, Long H, Hislop A, et al. Epstein-Barr virus evades CD4+ T cell responses in lytic cycle through BZLF1-mediated downregulation of CD74 and the cooperation of vBcl-2. PLoS Pathog. 2011;7:e1002455 pubmed publisher
    ..absence of a reduction in the expression of surface MHC-II, but correlated with a marked downregulation of surface CD74 on the target cells...
  41. Cho Y, Jones B, Vermeire J, Leng L, DiFedele L, Harrison L, et al. Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74. J Biol Chem. 2007;282:23447-56 pubmed
    ..were compared using in vitro assays of tautomerase activity, macrophage migration, and binding to MIF receptor CD74. The activity of rAceMIF was not inhibited by the ligand ISO-1, which was previously determined to be an inhibitor ..
  42. Chang H, Smallwood P, Williams J, Nathans J. Intramembrane Proteolysis of Astrotactins. J Biol Chem. 2017;292:3506-3516 pubmed publisher
    ..Astn2 intramembrane proteolysis is insensitive to replacement of TM2 by the transmembrane domain of CD74 or by 21 alanines...
  43. Li S, Li Q, Yang Y, Jin L, Sun Z, Yu S. Immunohistochemistry of lymphocytes in benign lymphoadenosis of oral mucosa. Genet Mol Res. 2015;14:7163-71 pubmed publisher
    ..The expression levels of CD74, CD20, CD3, and CD45RO were evaluated by immunohistochemical staining in 14 sam-ples from BLOM, 9 samples from BLOM ..
  44. Schröder B, Saftig P. Intramembrane proteolysis within lysosomes. Ageing Res Rev. 2016;32:51-64 pubmed publisher
    ..The signal peptide peptidase-like (SPPL) protease 2a is a lysosomal membrane component and cleaves CD74, the invariant chain of the MHC II complex, as well as FasL, TNF, ITM2B and TMEM106, type II transmembrane proteins ..
  45. Lozano Pope I, Sharma A, Matthias M, Doran K, Obonyo M. Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer. BMC Cancer. 2017;17:133 pubmed publisher
    ..1 (Ido1), Guanylate binding protein 2 (Gbp2), ubiquitin D (Ubd), ? 2 -Microglobulin (B2m), CD74 antigen (Cd74), which have been reported to promote cancer progression by enhancing angiogenesis, proliferation, ..
  46. Kvist S, Wiman K, Claesson L, Peterson P, Dobberstein B. Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens. Cell. 1982;29:61-9 pubmed
    ..This is followed by the detachment of DR gamma chains from the oligomeric complex and the appearance of DR alpha and DR beta chains on the cell surface. Whether any DR gamma chains appear on the cell surface is uncertain. ..
  47. Xiong C, Huang B, Zhou Y, Cun Y, Liu L, Wang J, et al. Macrophage migration inhibitory factor inhibits the migration of cartilage end plate-derived stem cells by reacting with CD74. PLoS ONE. 2012;7:e43984 pubmed publisher
    ..Recent studies have shown that MIF and its receptor, CD74, are involved in regulating the migration of human mesenchymal stem cells (MSCs); Thus, MIF might impair the ..
  48. Richard V, Kindt N, Decaestecker C, Gabius H, Laurent G, Noel J, et al. Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer. Oncol Rep. 2014;32:523-9 pubmed publisher
    Macrophage migration inhibitory factor (MIF) and its receptor CD74 appear to be involved in tumorigenesis...
  49. Schneppenheim J, Hüttl S, Kruchen A, Fluhrer R, Müller I, Saftig P, et al. Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells. Biochem Biophys Res Commun. 2014;451:48-53 pubmed publisher
    The invariant chain (CD74) mediates targeting of the MHCII complex to endosomal compartments, where CD74 undergoes degradation allowing MHCII to acquire peptides...
  50. Schwartz V, Lue H, Kraemer S, Korbiel J, Krohn R, Ohl K, et al. A functional heteromeric MIF receptor formed by CD74 and CXCR4. FEBS Lett. 2009;583:2749-57 pubmed publisher
    ..MIF also interacts with CD74/invariant chain, a single-pass membrane-receptor...
  51. Xie X, Zhan Y, Ye Y, Li C, Zhang Y. [Expression of macrophage migration inhibitory factor and CD74 in preeclamptic placenta and its correlation with preeclampsia]. Zhonghua Fu Chan Ke Za Zhi. 2010;45:278-82 pubmed
    To investigate the expression of macrophage migration inhibitory factor (MIF) and CD74, the receptor of MIF, in preeclamptic placenta and its correlation with the pathogenesis of preeclampsia...
  52. Fendler W, Klich I, Cieślik Heinrich A, Wyka K, Szadkowska A, Młynarski W. Increased risk of type 1 diabetes in Polish children - association with INS-IGF2 5'VNTR and lack of association with HLA haplotype. Endokrynol Pol. 2011;62:436-42 pubmed
    ..Class I homozygosity at 5'VNTR is a significant risk factor of T1DM and acts independently from HLA haplotype in determining the actual risk of diabetes in children. ..
  53. Kiyota T, Zhang G, Morrison C, Bosch M, Weir R, Lu Y, et al. AAV2/1 CD74 Gene Transfer Reduces β-amyloidosis and Improves Learning and Memory in a Mouse Model of Alzheimer's Disease. Mol Ther. 2015;23:1712-1721 pubmed publisher
    ..As CD74 binds to the amyloid-β precursor protein (APP) and can suppresses Aβ processing, we investigated whether ..
  54. Fromont G, Godet J, Pires C, Yacoub M, Dore B, Irani J. Biological significance of perineural invasion (PNI) in prostate cancer. Prostate. 2012;72:542-8 pubmed publisher
    ..analyzed using immunohistochemistry on TMA slides: macrophage migration inhibitory factor (MIF) and its receptor CD74, EGF receptor (EGFR), heregulin (HRG) and its receptor ErbB3, and the proliferation marker Ki67...
  55. Otterstrom C, Soltermann A, Opitz I, Felley Bosco E, Weder W, Stahel R, et al. CD74: a new prognostic factor for patients with malignant pleural mesothelioma. Br J Cancer. 2014;110:2040-6 pubmed publisher
    The pro-inflammatory cytokine migration inhibitory factor (MIF) and its receptor CD74 have been proposed as possible therapeutic targets in several cancers...
  56. David L, Gokhale A, Jois S, Johnson A, Behrens M, Luthra H, et al. CD74/DQA1 dimers predispose to the development of arthritis in humanized mice. Immunology. 2016;147:204-11 pubmed publisher
    ..Proximity ligation assay showed that DQA1*0103 is expressed on the cell surface as a dimer with CD74. Upon immunization with type II collagen, DQA1*0103 mice generated an antigen-specific cellular and humoral ..
  57. Fernandez Cuesta L, Plenker D, Osada H, Sun R, Menon R, Leenders F, et al. CD74-NRG1 fusions in lung adenocarcinoma. Cancer Discov. 2014;4:415-22 pubmed publisher
    We discovered a novel somatic gene fusion, CD74-NRG1, by transcriptome sequencing of 25 lung adenocarcinomas of never smokers...
  58. Wage J, Ma L, Peluso M, Lamont C, Evens A, Hahnfeldt P, et al. Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue. J Radiat Res. 2015;56:792-803 pubmed publisher
    ..Increases in cell cycling and immunosuppression in irradiated adolescent hosts with CDK2, MCM7, CD74 and RUVBL2 indicated these were the key genes involved in the regulatory changes in the host environment response (..
  59. Bell Temin H, Culver Cochran A, Chaput D, Carlson C, Kuehl M, Burkhardt B, et al. Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics. Mol Cell Proteomics. 2015;14:3173-84 pubmed publisher
    ..presumably to curtail inflammatory activation through differential protein expression, in the M2a state including CD74, LYN, SQST1, TLR2, and CD14...
  60. Hanlon A, Stasko T, Christiansen D, Cyrus N, Galan A. LN2, CD10, and Ezrin Do Not Distinguish Between Atypical Fibroxanthoma and Undifferentiated Pleomorphic Sarcoma or Predict Clinical Outcome. Dermatol Surg. 2017;43:431-436 pubmed publisher
    ..performed on primary and recurrent AFX and UPS tumors with monoclonal antibodies against the B-cell marker LN2 (CD74), CD10, and ezrin. In the series of 169 patients with AFX included in this study, local recurrence was rare at 3%...
  61. Pizzamiglio S, De Bortoli M, Taverna E, Signore M, Veneroni S, Cho W, et al. Expression of Iron-Related Proteins Differentiate Non-Cancerous and Cancerous Breast Tumors. Int J Mol Sci. 2017;18: pubmed publisher
    ..and activator of transcription 3 (STAT3), bone morphogenetic protein 6 (BMP6), cluster of differentiation 74 (CD74), transferrin receptor (TFRC), inhibin alpha (INHA), and STAT5_pY694...
  62. Hussain A, Wesley C, Khalid M, Chaudhry A, Jameel S. Human immunodeficiency virus type 1 Vpu protein interacts with CD74 and modulates major histocompatibility complex class II presentation. J Virol. 2008;82:893-902 pubmed
    ..The major histocompatibility complex class II (MHC II) invariant chain, also called Ii or CD74, was found to be one such protein...
  63. Lekomtsev S, Aligianni S, Lapao A, Burckstummer T. Efficient generation and reversion of chromosomal translocations using CRISPR/Cas technology. BMC Genomics. 2016;17:739 pubmed publisher
    ..CRISPR/Cas system to engineer cell lines in which chromosomal translocations are either generated de novo (CD74-ROS1) or existing translocations are reverted back to the original configuration (BCR-ABL1)...
  64. Liu M, Wang P, Zhao M, Liu D. Intestinal Dendritic Cells Are Altered in Number, Maturity and Chemotactic Ability in Fulminant Hepatic Failure. PLoS ONE. 2016;11:e0166165 pubmed publisher
    ..and spleen DCs were isolated by magnetic-activated cell sorting (MACS) and surface markers of DCs, namely CD11c, CD74, CD83 and CD86, were identified using flow cytometry...
  65. Bijlmakers M, Benaroch P, Ploegh H. Mapping functional regions in the lumenal domain of the class II-associated invariant chain. J Exp Med. 1994;180:623-9 pubmed
    ..The region between amino acids 163 and 183 was found to be essential for visualization of Ii chain homotrimers by covalent cross-linking. ..
  66. Badve S, Deshpande C, Hua Z, Logdberg L. Expression of invariant chain (CD 74) and major histocompatibility complex (MHC) class II antigens in the human fetus. J Histochem Cytochem. 2002;50:473-82 pubmed
    ..The invariant chain (Ii; CD74) plays a critical role in this process by influencing the expression and peptide loading of the MHC class II ..
  67. Coleman S, Madrid R, Van Damme N, Mitchell R, Bouchet J, Servant C, et al. Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif. J Virol. 2006;80:1837-49 pubmed
    ..The data suggest that the E160 residue plays a differential role in the modulation of leucine-dependent Nef-targets and support a model in which distinct AP complexes are used by Nef to modulate different cellular proteins. ..
  68. Haug M, Schepp C, Kalbacher H, Dannecker G, Holzer U. 70-kDa heat shock proteins: specific interactions with HLA-DR molecules and their peptide fragments. Eur J Immunol. 2007;37:1053-63 pubmed
    ..Our findings indicate that direct interaction between mammalian HSP70 and HLA-DR molecules could be involved in the HSP70-mediated enhancement of MHC class II-restricted peptide presentation and CD4(+) T cell activation. ..
  69. Nguyen Pham T, Lim M, Nguyen T, Lee Y, Jin C, Lee H, et al. Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists. Cell Mol Immunol. 2011;8:341-7 pubmed publisher
    ..CD38 can be used as a multifunctional marker to modulate migration, survival and Th1 responses of DCs. CD74 has been shown to negatively regulate DC migration...
  70. Basmaciogullari S, Pizzato M. The activity of Nef on HIV-1 infectivity. Front Microbiol. 2014;5:232 pubmed publisher
    ..Here we review the current knowledge surrounding such activity and we discuss its possible role in HIV biology. ..
  71. Hsieh C, Chen C, Lin Y, Yeh T, Tsai T, Hong M, et al. Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+ NKT cells in chemically induced IFN-γ-mediated skin inflammation. J Immunol. 2014;193:3693-703 pubmed publisher
    ..MIF specifically triggered the chemotaxis of NKT cells via CD74 and CXCR2, and the resulting depletion of NKT cells abolished TPA-induced skin inflammation...
  72. Hasby E, Khalifa R. Expression of CD74 in invasive breast carcinoma: its relation to Nottingham Prognostic Index, hormone receptors, and HER2 immunoprofile. Tumori. 2017;103:193-203 pubmed publisher
    To study the immunohistochemical expression of CD74 in series of invasive breast carcinomas classified according to their estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) ..
  73. Yang L, Liu Z, Ren H, Zhang L, Gao S, Ren L, et al. DR?1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury. Metab Brain Dis. 2017;32:1395-1402 pubmed publisher
    ..demonstrated that daily injections of DR?1-MOG-35-55 given after FPI significantly reduced numbers of infiltrating CD74+ and CD86+ macrophages and increased numbers of CD206+ microglia in the brain ..
  74. Chatterjee P, Chiasson V, Seerangan G, De Guzman E, Milad M, Bounds K, et al. Depletion of MHC class II invariant chain peptide or ?-? T-cells ameliorates experimental preeclampsia. Clin Sci (Lond). 2017;131:2047-2058 pubmed publisher
  75. Genuardi M, Saunders G. Localization of the HLA class II-associated invariant chain gene to human chromosome band 5q32. Immunogenetics. 1988;28:53-6 pubmed
  76. Beswick E, Bland D, Suarez G, Barrera C, Fan X, Reyes V. Helicobacter pylori binds to CD74 on gastric epithelial cells and stimulates interleukin-8 production. Infect Immun. 2005;73:2736-43 pubmed
    ..pylori with the class II major histocompatibility complex (MHC)-associated invariant chain (Ii; CD74), which was found to be highly expressed by gastric epithelial cells...
  77. Dixon A, Stanley B, Matthews E, Dawson J, Engelman D. Invariant chain transmembrane domain trimerization: a step in MHC class II assembly. Biochemistry. 2006;45:5228-34 pubmed
  78. Powis S. CLIP-region mediated interaction of Invariant chain with MHC class I molecules. FEBS Lett. 2006;580:3112-6 pubmed
    ..Ii can also be detected in the class I MHC peptide loading complex. These data provide an explanation for the association of Ii and MHC class I molecules. ..
  79. Mitchell R, Chaudhuri R, Lindwasser O, Tanaka K, Lau D, Murillo R, et al. Competition model for upregulation of the major histocompatibility complex class II-associated invariant chain by human immunodeficiency virus type 1 Nef. J Virol. 2008;82:7758-67 pubmed publisher
    ..These data indicate that Nef usurps AP-2 complexes to dysregulate Ii trafficking and potentially interfere with antigen presentation in the context of MHC-II. ..
  80. Koskinen L, Einarsdottir E, Korponay Szabo I, Kurppa K, Kaukinen K, Sistonen P, et al. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. Tissue Antigens. 2009;74:408-16 pubmed publisher
    ..Our study strongly supports the role of the CELIAC2 locus in celiac disease, but it also highlights the need for a more powerful study design in the region, to locate the true disease risk variants. ..
  81. Matsuda S, Matsuda Y, D ADAMIO L. CD74 interacts with APP and suppresses the production of Abeta. Mol Neurodegener. 2009;4:41 pubmed publisher
    ..Here, we show that CD74, the invariant chain of class II major histocompatibility complex, interacts with APP and serves as a negative ..
  82. van Luijn M, Chamuleau M, Ressing M, Wiertz E, Ostrand Rosenberg S, Souwer Y, et al. Alternative Ii-independent antigen-processing pathway in leukemic blasts involves TAP-dependent peptide loading of HLA class II complexes. Cancer Immunol Immunother. 2010;59:1825-38 pubmed publisher
  83. Alinari L, Mahoney E, Patton J, Zhang X, Huynh L, Earl C, et al. FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death. Blood. 2011;118:6893-903 pubmed publisher
    ..FTY720-mediated disruption of the autophagic-lysosomal pathway led to increased levels of CD74, a potential therapeutic target in MCL that is degraded in the lysosomal compartment...
  84. Zheng Y, Yang M, Rong T, Yuan X, Ma Y, Wang Z, et al. CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer. World J Gastroenterol. 2012;18:2253-61 pubmed publisher
    To investigate the relationship and molecular features of CD74/macrophage migration inhibitory factor (MIF)/Toll-like receptor 4 (TLR4) in gastric cancer...
  85. Walline C, Deffit S, Wang N, Guindon L, Crotzer V, Liu J, et al. Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy. Immunology. 2014;141:531-9 pubmed publisher
    ..MHCII and CD1d molecules associate with a conserved intracellular chaperone, CD74, also known as invariant chain...
  86. Tan X, Wu Q, Cai Y, Zhao X, Wang S, Gao Z, et al. Novel association between CD74 polymorphisms and hematologic toxicity in patients with NSCLC after platinum-based chemotherapy. Clin Lung Cancer. 2014;15:67-78.e12 pubmed publisher
    ..the activity of the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex or activating its receptor, CD74. We used a pathway-based approach to investigate the association between genetic polymorphisms in MIF-pathway genes ..
  87. Meza Romero R, Benedek G, Yu X, Mooney J, Dahan R, Duvshani N, et al. HLA-DR?1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis. J Immunol. 2014;192:4164-73 pubmed publisher
    b>CD74, the cell-surface form of the MHC class II invariant chain, is a key inflammatory factor that is involved in various immune-mediated diseases as part of the macrophage migration inhibitory factor (MIF) binding complex...
  88. Richard V, Kindt N, Saussez S. Macrophage migration inhibitory factor involvement in breast cancer (Review). Int J Oncol. 2015;47:1627-33 pubmed publisher
    ..MIF interacts with its main receptor CD74 and its co-receptor CXCR-4, both overexpressed, promoting cell survival by PI3K/Akt activation, a possible link ..
  89. Bozzi F, Mogavero A, Varinelli L, Belfiore A, Manenti G, Caccia C, et al. MIF/CD74 axis is a target for novel therapies in colon carcinomatosis. J Exp Clin Cancer Res. 2017;36:16 pubmed publisher
    ..Organoids were treated with 4-IPP, an inhibitor of MIF/CD74 signalling axis which activates AMPK function, or metformin that inhibits mitochondrial respiratory chain complex I...
  90. Cortés M, Sanchez Moral L, de Barrios O, Fernández Aceñero M, Martínez Campanario M, Esteve Codina A, et al. Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles. EMBO J. 2017;36:3336-3355 pubmed publisher
    ..phenotype, including direct activation of Ccr2 In turn, expression of ZEB1 by TAMs induced Ccl2, Cd74, and a mesenchymal/stem-like phenotype in cancer cells...
  91. Riberdy J, Newcomb J, Surman M, Barbosa J, Cresswell P. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature. 1992;360:474-7 pubmed
    ..Addition of synthetic CLIP inhibits the loading process, indicating that CLIP may define the region of the invariant chain responsible for obstructing the class II binding site. ..
  92. O Sullivan D, Noonan D, Quaranta V. Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation. J Exp Med. 1987;166:444-60 pubmed