CD69

Summary

Gene Symbol: CD69
Description: CD69 molecule
Alias: AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3, early activation antigen CD69, C-type lectin domain family 2, member C, CD69 antigen (p60, early T-cell activation antigen), activation inducer molecule (AIM/CD69), early T-cell activation antigen p60, early lymphocyte activation antigen, leukocyte surface antigen Leu-23
Species: human
Products:     CD69

Top Publications

  1. Dusséaux M, Masse Ranson G, Darche S, Ahodantin J, Li Y, Fiquet O, et al. Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver. Gastroenterology. 2017;153:1647-1661.e9 pubmed publisher
    ..HBV-infected HIS-HUHEP livers contained infiltrating Kupffer cells, mature activated natural killer cells (CD69+), and PD-1+ effector memory T cells (CD45RO+)...
  2. Vega Angeles V, Terrazas L, Ledesma Soto Y, Jimenez L, Landa A. Taenia solium glutathione transferase fraction activates macrophages and favors the development of Th1-type response. Biosci Rep. 2019;39: pubmed publisher
    ..of CD4+ cells, induced high interferon-γ (IFN-γ) secretion, and elevated the expression of CD25 and CD69, molecules associated with cell activation. Similar assay using T CD4+ cells from DO11...
  3. Kim Y, Park K, Jang S, Lee K, Byun J, Suh K, et al. HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus. Arthritis Res Ther. 2017;19:211 pubmed publisher
    ..suppressed splenic B220+GL7+, B220+CD138+, and B220+CD69+ B cell counts, and anti-dsDNA IgG and reduced splenomegaly and lymph node enlargement...
  4. Coppola A, Tomasello L, Pitrone M, Cillino S, Richiusa P, Pizzolanti G, et al. Human limbal fibroblast-like stem cells induce immune-tolerance in autoreactive T lymphocytes from female patients with Hashimoto's thyroiditis. Stem Cell Res Ther. 2017;8:154 pubmed publisher
    ..apoptosis cascade, inverted the CD4/CD8 ratio, and promoted sustained expression of the immunomodulator marker CD69. Under coculture conditions the Th imbalance of autoreactive T cells from female HT patients was fully restored...
  5. Kozela E, Juknat A, Gao F, Kaushansky N, Coppola G, Vogel Z. Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. J Neuroinflammation. 2016;13:136 pubmed publisher
    ..In addition, CBD enhanced the transcription of T cell co-inhibitory molecules (Btla, Lag3, Trat1, and CD69) known to interfere with T/APC interactions...
  6. Andrés Blasco I, Vinue A, Herrero Cervera A, Martinez Hervas S, Núñez L, Piqueras L, et al. Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/Lymphotoxin ?-Receptor pathway. Thromb Haemost. 2016;116:379-93 pubmed publisher
    ..with apoE-/-Irs2+/-HL+/+ mice, MCP1, TNF? and IL6 plasma levels, pro-inflammatory Ly6Chi monocytes and activated(CD69+)-T lymphocytes were also decreased in apoE-/-Irs2+/-HL-/- mice...
  7. Koo T, Lee J, Yan J, Jang J, Ju K, Han M, et al. The P2X7 receptor antagonist, oxidized adenosine triphosphate, ameliorates renal ischemia-reperfusion injury by expansion of regulatory T cells. Kidney Int. 2017;92:415-431 pubmed publisher
    ..The infiltration of dendritic cells, neutrophils, macrophages, CD69+CD4+, and CD44+CD4+ T cells was attenuated, but renal Foxp3+..
  8. Qin J, Lin J, Ding W, Wu W. Schisandrin B Improves the Renal Function of IgA Nephropathy Rats Through Inhibition of the NF-κB Signalling Pathway. Inflammation. 2018;: pubmed publisher
    ..interleukin-1β, and monocyte chemoattractant protein-1 in the kidney, and decreased the numbers of CD3+CD69+ cells in the spleen...
  9. Li M, Bai Y, Zhou J, Huang W, Yan J, Tao J, et al. Core Fucosylation of Maternal Milk N-Glycan Evokes B Cell Activation by Selectively Promoting the l-Fucose Metabolism of Gut Bifidobacterium spp. and Lactobacillus spp. MBio. 2019;10: pubmed publisher
    ..Moreover, these offspring mice showed a lower proportion of splenic CD19+ CD69+ B lymphocytes and attenuated humoral immune responses upon ovalbumin (OVA) immunization...

More Information

Publications158 found, 100 shown here

  1. Vogel A, Brown D. Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells. Front Immunol. 2015;6:327 pubmed publisher
    ..Three days after immunization, CD4 and CD8 cells in the lung upregulated CD69, suggesting that activated lymphocytes are present at the site of vaccine administration...
  2. Schub D, Assmann G, Sester U, Sester M, Schmidt T. VZV-specific T-cell levels in patients with rheumatic diseases are reduced and differentially influenced by antirheumatic drugs. Arthritis Res Ther. 2018;20:252 pubmed publisher
    ..of cytokines (interferon-γ, tumor necrosis factor [TNF]-α, interleukin [IL]-2) and markers for activation (CD69), differentiation (CD127), or functional anergy programmed death 1 molecule [PD-1], cytotoxic T-lymphocyte antigen ..
  3. Kovats S, Turner S, Simmons A, Powe T, Chakravarty E, Alberola Ila J. West Nile virus-infected human dendritic cells fail to fully activate invariant natural killer T cells. Clin Exp Immunol. 2016;186:214-226 pubmed publisher
    ..Unexpectedly, we found that the WNV-infected DCs stimulated human iNKTs to up-regulate CD69 and produce low amounts of IL-10, but not proinflammatory cytokines such as IFN-? or tumour necrosis factor (TNF)-?...
  4. Jacquier V, Estellé J, Schmaltz Panneau B, Lecardonnel J, Moroldo M, Lemonnier G, et al. Genome-wide immunity studies in the rabbit: transcriptome variations in peripheral blood mononuclear cells after in vitro stimulation by LPS or PMA-Ionomycin. BMC Genomics. 2015;16:26 pubmed publisher
    ..IFNG and by contrast to other cytokines which significantly decreased from T4 to T24 (IL2, IL4, IL10, IL13, IL17A, CD69) by comparison to mock-stimulation...
  5. Patil N, Luan L, Bohannon J, Guo Y, Hernandez A, Fensterheim B, et al. IL-15 Superagonist Expands mCD8+ T, NK and NKT Cells after Burn Injury but Fails to Improve Outcome during Burn Wound Infection. PLoS ONE. 2016;11:e0148452 pubmed publisher
    ..IL-15 treatment inhibited this decline and significantly increased cell numbers and activation, as determined by CD69 expression, of CD4+, CD8+, B, NK and NKT cells in the spleen and liver after burn injury...
  6. Amico D, Spadoni T, Rovinelli M, Serafini M, D Amico G, Campelli N, et al. Intracellular free radical production by peripheral blood T lymphocytes from patients with systemic sclerosis: role of NADPH oxidase and ERK1/2. Arthritis Res Ther. 2015;17:68 pubmed publisher
    ..Intracellular ROS generation was measured using a DCFH-DA assay in a plate reader fluorimeter or by FACS analysis. CD69 expression and cytokine production were analyzed by FACS analysis...
  7. Velazquez K, Enos R, Carson M, Cranford T, Bader J, Chatzistamou I, et al. Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model. Am J Physiol Gastrointest Liver Physiol. 2016;311:G699-G712 pubmed publisher
    ..a higher percentage of F4/80+CD206+ macrophages and activated T cells (CD4+CD69+) in the spleen and lymph nodes, respectively...
  8. Lukic J, Jančić I, Mirkovic N, Bufan B, Djokic J, Milenkovic M, et al. Lactococcus lactis and Lactobacillus salivarius differently modulate early immunological response of Wistar rats co-administered with Listeria monocytogenes. Benef Microbes. 2017;8:809-822 pubmed publisher
    ..MLN of BGHO1 treated rats, LLO expression was increased, along with an increase of the expression of OX-62 mRNA and CD69, pointing to the activation of adaptive immunity...
  9. Galeotti C, Stephen Victor E, Karnam A, Das M, Gilardin L, Maddur M, et al. Intravenous immunoglobulin induces IL-4 in human basophils by signaling through surface-bound IgE. J Allergy Clin Immunol. 2018;: pubmed publisher
    ..Activation of basophils by IVIG led to enhanced expression of CD69 and secretion of IL-4, IL-6, and IL-8...
  10. Singh M, Jamal F, Dubey A, Shivam P, Kumari S, Pushpanjali -, et al. Co-factor-independent phosphoglycerate mutase of Leishmania donovani modulates macrophage signalling and promotes T-cell repertoires bearing epitopes for both MHC-I and MHC-II. Parasitology. 2017;:1-15 pubmed publisher
    ..rLd-iPGAM stimulation induced higher expression of interleukin-1? (IL-1?) in the phagocytic cell, its receptor and CD69 on T-cell subsets...
  11. Ghosh S, Nandi M, Pal S, Mukhopadhyay D, Chakraborty B, Khatun M, et al. Natural killer cells contribute to hepatic injury and help in viral persistence during progression of hepatitis B e-antigen-negative chronic hepatitis B virus infection. Clin Microbiol Infect. 2016;22:733.e9-733.e19 pubmed publisher
    ..2%, e(-)CHB 13.2% and LC 14.4%). Higher proportion of NK cells from LC/e(-)CHB expressed CD69, NKp46, NKp44, TRAIL and perforin, the last two being prominent features of CD56(bright) and CD56(dim) NK subsets, ..
  12. Simpfendorfer K, Wang N, Tull D, De Souza D, Nahid A, Mu A, et al. Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome. Mol Med. 2019;25:12 pubmed publisher
    ..redefined as CD8α+αβ+ T cells, the majority of which expressed high levels of CD103 and CD69 consistent with tissue resident memory T cells (TRM)...
  13. Lima L, Molina M, Pereira B, Nadaf M, Nadaf M, Takano O, et al. Acquisition of specific antibodies and their influence on cell-mediated immune response in neonatal cord blood after maternal pertussis vaccination during pregnancy. Vaccine. 2019;37:2569-2579 pubmed publisher
    ..Whole blood assays revealed that newborns responded to Bp stimulation with higher expression of CD40L, CD69 and CD4+ T cell proliferation compared to unstimulated cells, and a lower Th1 response, while a ..
  14. Hsiao E, Patterson P. Activation of the maternal immune system induces endocrine changes in the placenta via IL-6. Brain Behav Immun. 2011;25:604-15 pubmed publisher
    ..Placentas from MIA mothers exhibit increases in CD69+ decidual macrophages, granulocytes and uterine NK cells, indicating elevated early immune activation...
  15. Pato A, Eisenberg G, Machlenkin A, Margalit A, Cafri G, Frankenburg S, et al. Messenger RNA encoding constitutively active Toll-like receptor 4 enhances effector functions of human T cells. Clin Exp Immunol. 2015;182:220-9 pubmed publisher
    ..CD8 and CD4 T cells induced the production of interferon (IFN)-γ, triggered the surface expression of CD25, CD69 and 4-1BB and up-regulated a panel of cytokines and chemokines...
  16. Carlsson J, Wold A, Sandberg A, Östman S. The Polyunsaturated Fatty Acids Arachidonic Acid and Docosahexaenoic Acid Induce Mouse Dendritic Cells Maturation but Reduce T-Cell Responses In Vitro. PLoS ONE. 2015;10:e0143741 pubmed publisher
    ..However, fewer T cells co-cultured with these DCs proliferated (CellTrace Violet low) and expressed CD69 or CD25, while more were necrotic (7AAD+)...
  17. Beigier Bompadre M, Montagna G, Kuhl A, Lozza L, Weiner J, Kupz A, et al. Mycobacterium tuberculosis infection modulates adipose tissue biology. PLoS Pathog. 2017;13:e1006676 pubmed publisher
    ..IFN-?-producing NK cells and Mtb-specific CD8+ T cells were identified in perigonadal fat, specifically CD8+CD44-CD69+ and CD8+CD44-CD103+ subpopulations...
  18. Lapuente D, Storcksdieck Genannt Bonsmann M, Maaske A, Stab V, Heinecke V, Watzstedt K, et al. IL-1β as mucosal vaccine adjuvant: the specific induction of tissue-resident memory T cells improves the heterosubtypic immunity against influenza A viruses. Mucosal Immunol. 2018;11:1265-1278 pubmed publisher
    ..effects on the local T cell responses were much more impressive reflected by increased numbers of CD103+CD69+ tissue-resident memory T cells (TRM)...
  19. Jaime Ramirez A, McMichael E, Kondadasula S, Skinner C, Mundy Bosse B, Luedke E, et al. NK Cell-Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines. Cancer Immunol Res. 2016;4:323-336 pubmed publisher
    ..NK) cell Fc receptors led to phosphorylation of the ERK transcription factor and increased NK cell expression of CD69. Lysis of KB tumor cells by NK cells increased by about 5-fold after treatment with F-IgG, an effect ..
  20. Zhou S, Chen W, Shi Z, Wang S, Li L, Wen X, et al. Silencing the expression of Cbl-b enhances the immune activation of T lymphocytes against RM-1 prostate cancer cells in vitro. J Chin Med Assoc. 2014;77:630-6 pubmed publisher
    ..The expression of CD69, CD25, and CD71 by the transfected T lymphocytes was determined by flow cytometry...
  21. Geerman S, Hickson S, Brasser G, Pascutti M, Nolte M. Quantitative and Qualitative Analysis of Bone Marrow CD8(+) T Cells from Different Bones Uncovers a Major Contribution of the Bone Marrow in the Vertebrae. Front Immunol. 2015;6:660 pubmed publisher
    ..memory phenotype and observed that approximately half of all TEM cells expressed the retention marker CD69. Remarkably, in the memory phase of acute infection with the lymphocytic choriomeningitis virus (LCMV), we found a ..
  22. Gyurkovska V, Ivanovska N. Tyrosine kinase inhibitor tyrphostin AG490 reduces liver injury in LPS-induced shock. Eur J Pharmacol. 2015;751:118-26 pubmed publisher
    ..Cytokine and chemokine blood levels were determined by ELISA assays. CD11b(+) Ly6C(+), CD3(+)CD69(+) and C5aR positive cell populations in the peritoneal exudate were detected by flow cytometry...
  23. Tajuddin S, Schick U, Eicher J, Chami N, Giri A, Brody J, et al. Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases. Am J Hum Genet. 2016;99:22-39 pubmed publisher
    ..loci included genes encoding surface markers of myeloid, lymphoid, or hematopoietic stem cell differentiation (CD69, CD33, CD87), transcription factors regulating lineage specification during hematopoiesis (ASXL1, IRF8, IKZF1, ..
  24. Hosokawa K, Kajigaya S, Keyvanfar K, Qiao W, Xie Y, Townsley D, et al. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways. J Immunol. 2017;199:477-488 pubmed publisher
    ..genes (JUN, TNFAIP3, TOB1, GIMAP4, GIMAP6, TRMT112, NR4A2, CD69, and TNFSF8) was validated by quantitative real-time RT-PCR and flow cytometry...
  25. Singh M, Jamal F, Dubey A, Shivam P, Kumari S, Pushpanjali -, et al. Visceral leishmaniasis: A novel nuclear envelope protein 'nucleoporins-93 (NUP-93)' from Leishmania donovani prompts macrophage signaling for T-cell activation towards host protective immune response. Cytokine. 2019;113:200-215 pubmed publisher
    ..rLd-NUP93 stimulation increased the expression of the early lymphocyte activation marker CD69 on CD4+ and CD8+ T cells...
  26. Bagheri S, Yousefi M, Safaie Qamsari E, Riazi Rad F, Abolhassani M, Younesi V, et al. Selection of single chain antibody fragments binding to the extracellular domain of 4-1BB receptor by phage display technology. Tumour Biol. 2017;39:1010428317695924 pubmed publisher
    ..Anti-4-1BB single chain variable fragments enhanced surface CD69 expression and interleukin-2 production in stimulated CCRF-CEM cells which confirmed the agonistic effect of the ..
  27. da Silva T, Oliveira Brito P, Gonçalves T, Vendruscolo P, Roque Barreira M. ArtinM Mediates Murine T Cell Activation and Induces Cell Death in Jurkat Human Leukemic T Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..We showed that ArtinM activates murine CD4⁺ and CD8⁺ T cells, augmenting their positivity for CD25, CD69, and CD95 and showed higher interleukin (IL)-2 and interferon (IFN)-γ production...
  28. Aguilar Valenzuela R, Netland J, Seo Y, Bevan M, Grakoui A, Suthar M. Dynamics of Tissue-Specific CD8+ T Cell Responses during West Nile Virus Infection. J Virol. 2018;92: pubmed publisher
    ..gamma interferon [IFN-γ] and tumor necrosis factor alpha [TNF-α]), displayed tissue-resident characteristics (CD69+ and CD103+), persisted in the brain through day 15 p.i...
  29. Nenasheva T, Nikolaev A, Diykanov D, Sukhanova A, Tcyganov E, Panteleev A, et al. The introduction of mesenchymal stromal cells induces different immunological responses in the lungs of healthy and M. tuberculosis infected mice. PLoS ONE. 2017;12:e0178983 pubmed publisher
    ..Compared to uninfected mice, Mtb infected mice had statistically higher "background" frequency of activated CD69+ and IFN-?+ CD4+ lymphocytes and dendritic cells, and higher levels of cytokines in the lungs...
  30. Costa V, Ye W, Chen Q, Teixeira M, Preiser P, Ooi E, et al. Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules. MBio. 2017;8: pubmed publisher
    ..cells (MDDCs), but not monocytes, activate NK cells in a contact-dependent manner, resulting in upregulation of CD69 and CD25 and secretion of IFN-γ...
  31. Vähätupa M, Aittomaki S, Martinez Cordova Z, May U, Prince S, Uusitalo Jarvinen H, et al. T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development. Oncoimmunology. 2016;5:e1245266 pubmed publisher
    ..skin draining lymph nodes showed that FURIN T-cell KO mice have an inherent upregulation of early activation marker CD69 as well as more CD4+CD25+Foxp3+ positive T regulatory cells...
  32. Kelly E, Esnault S, Liu L, Evans M, Johansson M, Mathur S, et al. Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype in Asthma. Am J Respir Crit Care Med. 2017;: pubmed publisher
    ..lavage eosinophils had more surface interleukin-3 and granulocyte-monocyte colony-stimulating factor receptors, CD69, CD44, and CD23 and decreased interleukin-5 and eotaxin receptors than blood eosinophils...
  33. Hamilton J, Li J, Wu Q, Yang P, Luo B, Li H, et al. General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice. J Immunol. 2015;194:5022-34 pubmed publisher
    ..marginal zone precursor, transitional T3, and PDL-2(+)CD80(+) memory B cells, with significantly elevated CD69 and CD86 observed in RBP(+) marginal zone precursor B cells in the spleens of BXD2 mice compared with C57BL/6 mice, ..
  34. Trischler J, Shiomi T, Turner D, Sklepkiewicz P, Goldklang M, Tanaka K, et al. Immune Modulation of the T Cell Response in Asthma through Wnt10b. Am J Respir Cell Mol Biol. 2016;54:584-93 pubmed publisher
    ..dust mite sensitization, which indicated a heightened activation state, measured by an increased percentage of CD69(hi)CD11a(hi) cells...
  35. Lau M, Keith P, Costello M, Bradbury L, Hollis K, Thomas R, et al. Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis. Ann Rheum Dis. 2017;76:261-269 pubmed publisher
    ..T-bet+ innate and adaptive immune cells have altered IL-17 and IFN?, and early activation marker CD69 expression than T-bet cells...
  36. Khan T, Mooster J, Kilgore A, Osborn J, Nolz J. Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection. J Exp Med. 2016;213:951-66 pubmed publisher
    ..Secondary antigen stimulation in nonlymphoid tissue caused CD8(+) T cells to rapidly express CD69 and be retained at the site of infection...
  37. Xiao M, Ding L, Yang W, Chai L, Sun Y, Yang X, et al. St20, a new venomous animal derived natural peptide with immunosuppressive and anti-inflammatory activities. Toxicon. 2017;127:37-43 pubmed publisher
    ..Functional studies showed that St20 inhibited human T lymphocyte surface marker CD69 expression and cytokine IL-2 secretion...
  38. Schoknecht T, Schwinge D, Stein S, Weiler Normann C, Sebode M, Mucha S, et al. CD4+ T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down-regulation of proapoptotic Bim in peripheral blood. J Leukoc Biol. 2017;101:589-597 pubmed publisher
    ..PSC was not due to reduced cell activation, as indicated by a similar surface expression of the activation markers CD69, CD25, and CD28 in T cells from patients and controls...
  39. Houng J, Tai T, Hsu S, Hsu H, Hwang T, Lin C, et al. Glossogyne tenuifolia (Hsiang-ju) extract suppresses T cell activation by inhibiting activation of c-Jun N-terminal kinase. Chin Med. 2017;12:9 pubmed publisher
    ..T cell activation was examined by a proliferation assay of activated PBMCs and the level of the activation marker CD69 on the surface of activated Jurkat T cells...
  40. Wilk M, Misiak A, McManus R, Allen A, Lynch M, Mills K. Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis. J Immunol. 2017;199:233-243 pubmed publisher
    ..Furthermore, CD4 T cells with a TRM cell phenotype (CD44+CD62L-CD69+ or CD44+CD62L-CD69+CD103+) accumulated in the lungs of mice ..
  41. Colbeck E, Hindley J, Smart K, Jones E, Bloom A, Bridgeman H, et al. Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors. Oncotarget. 2015;6:24649-59 pubmed publisher
    ..We did however find that unlike Tconvs, the majority of intra-tumoral Tregs express the activation markers CD69, CD25, ICOS, CD103 and CTLA4 and are significantly more proliferative than Tconvs...
  42. Lin C, Wei T, Tsai H, Wu Y, Wu P, Chen S. Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation. FASEB J. 2015;29:5006-17 pubmed publisher
    ..By RNA interference, we show that CD69 is not sufficient to support the conversion of CD4(+) naive T cells into Treg cells, whereas it does that of human ..
  43. Klein Wieringa I, de Lange Brokaar B, Yusuf E, Andersen S, Kwekkeboom J, Kroon H, et al. Inflammatory Cells in Patients with Endstage Knee Osteoarthritis: A Comparison between the Synovium and the Infrapatellar Fat Pad. J Rheumatol. 2016;43:771-8 pubmed publisher
    ..cells had a memory phenotype and contained a significant population of cells expressing activation markers (CD25+, CD69+). Interestingly, the percent of CD69+ T cells was higher in synovial than IFP CD4+ T cells...
  44. Kang J, Lee J, Chang J. Cholera Toxin Promotes Th17 Cell Differentiation by Modulating Expression of Polarizing Cytokines and the Antigen-Presenting Potential of Dendritic Cells. PLoS ONE. 2016;11:e0157015 pubmed publisher
    ..By analyzing the expression of activation markers such as CD25 and CD69, proliferation and IL-2 production, we determined that CT-treated BMDCs showed diminished antigen-presenting ..
  45. Le Gars M, Kay A, Bayless N, Aziz N, Dekker C, Swan G, et al. Increased Proinflammatory Responses of Monocytes and Plasmacytoid Dendritic Cells to Influenza A Virus Infection During Pregnancy. J Infect Dis. 2016;214:1666-1671 pubmed
    ..0-fold), CD69 (approximately 2.2-fold), interferon ?-induced protein 10 (approximately 2...
  46. Jeffery H, McDowell P, Lutz P, Wawman R, Roberts S, Bagnall C, et al. Human intrahepatic ILC2 are IL-13positive amphiregulinpositive and their frequency correlates with model of end stage liver disease score. PLoS ONE. 2017;12:e0188649 pubmed publisher
    ..ILC2 displayed a tissue resident CD69+ CD161++ phenotype and expressed chemokine receptor CCR6 allowing them to respond to CCL20 secreted by ..
  47. Kolenko P, Skalova T, Vanek O, Stěpánková A, Duskova J, Hasek J, et al. The high-resolution structure of the extracellular domain of human CD69 using a novel polymer. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009;65:1258-60 pubmed publisher
    The structure of the extracellular domain of human CD69 has been determined by single-crystal X-ray diffraction. The structure refined to 1...
  48. Fossati M, Buzzonetti A, Monego G, Catzola V, Scambia G, Fattorossi A, et al. Immunological changes in the ascites of cancer patients after intraperitoneal administration of the bispecific antibody catumaxomab (anti-EpCAM×anti-CD3). Gynecol Oncol. 2015;138:343-51 pubmed publisher
    ..I.p. catumaxomab infusion enhanced the expression of the CD69 and CD38 activation molecules in CD4(+) and CD8(+) T cells, NK cells and macrophages, and favoured CD8(+) T cell ..
  49. Abbasi A, de Paula Vieira R, Bischof F, Walter M, Movassaghi M, Berchtold N, et al. Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise. J Neuroinflammation. 2016;13:289 pubmed
    ..Genes differentially regulated between sexes included TNIP-1, TNIP-3, IL-6, HIVEP1, CXCL3, CCR3, IL-8, and CD69, revealing a bias towards less anti-inflammatory gene regulation in women compared to men...
  50. Notario L, Alari Pahissa E, de Molina A, Lauzurica P. CD69 Deficiency Enhances the Host Response to Vaccinia Virus Infection through Altered NK Cell Homeostasis. J Virol. 2016;90:6464-6474 pubmed publisher
    During the host response to viral infection, the transmembrane CD69 protein is highly upregulated in all immune cells...
  51. Johnson S, Levingston C, Young M. Premalignant Oral Lesion Cells Elicit Increased Cytokine Production and Activation of T-cells. Anticancer Res. 2016;36:3261-70 pubmed
    ..media, CD4(+) T cell expression of the IL-2 receptor CD25 and CD8(+) T cell expression of the activation marker CD69 was greater, compared to what was induced in HNSCC cell-conditioned media or media alone...
  52. Marquardt N, Kekäläinen E, Chen P, Kvedaraite E, Wilson J, Ivarsson M, et al. Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69-CD56dim cells. J Allergy Clin Immunol. 2017;139:1321-1330.e4 pubmed publisher
    ..Furthermore, we detected a small subset of NK cells expressing CD69, a marker of tissue residency...
  53. Raynor J, Karns R, Almanan M, Li K, Divanovic S, Chougnet C, et al. IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age. J Immunol. 2015;195:944-52 pubmed publisher
    ..were of an effector phenotype (CD44(hi)CD62L(lo)) and could be further characterized by high levels of ICOS and CD69. ICOS contributed to Treg maintenance in aged mice, because in vivo Ab blockade of ICOSL led to a loss of eTregs, ..
  54. Morabito C, Lanuti P, Caprara G, Guarnieri S, Verratti V, Ricci G, et al. Responses of peripheral blood mononuclear cells to moderate exercise and hypoxia. Scand J Med Sci Sports. 2016;26:1188-99 pubmed publisher
    ..After a period of normoxic physical exercise, the PBMCs showed an increase in fully activated T lymphocytes (CD3(+) CD69(+) ) and a reduction in intracellular Ca(2+) levels...
  55. Saba E, Panina Bordignon P, Pagani I, Origoni M, Candiani M, Doglioni C, et al. 5-Hydroxytyrosol inhibits HIV-1 replication in primary cells of the lower and upper female reproductive tract. Antiviral Res. 2017;142:16-20 pubmed publisher
    ..alterations of the activation profile of CD4+ and CD8+ T cells, in terms of CD4, CCR5, CD25, CD69 and HLA-DR expression, although it decreased the percentage of CD38+CD8+ T cells...
  56. Yang M, Kohler M, Heyder T, Forsslund H, Garberg H, Karimi R, et al. Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD. Respir Res. 2018;19:40 pubmed publisher
    ..correlated with FEV1/FVC as well as the percentage of CD8+ T-cells and CD8+CD69+ T-cells in smokers. The correlations to clinical parameters in healthy never-smokers were minor...
  57. Judge C, Reyes Aviles E, Conry S, Sieg S, Feng Z, Weinberg A, et al. HBD-3 induces NK cell activation, IFN-γ secretion and mDC dependent cytolytic function. Cell Immunol. 2015;297:61-8 pubmed publisher
    ..on NK cells, and in purified NK culture experiments we observed hBD-3 to directly act on NK cells, resulting in CD69 upregulation and IFNγ secretion. We also observed mDC-hBD-3 enhanced NK cytolytic activity and IFNγ production...
  58. Abravanel F, Barragué H, Dörr G, Sauné K, Péron J, Alric L, et al. Conventional and innate lymphocytes response at the acute phase of HEV infection in transplanted patients. J Infect. 2016;72:723-730 pubmed publisher
    ..In acutely-infected SOT patients, NK and Vδ2 cells, but not other γδ cells, had an increased expression of CD69. Based on CD45RA/CD27 markers, solid-organ recipients infected with HEV contained a larger pool of circulating ..
  59. Liu Y, Nie W, Jin Y, Zhuo A, Zang Y, Xiu Q. B and T Lymphocyte Attenuator is a Target of miR-155 during Naïve CD4+ T Cell Activation. Iran J Immunol. 2016;13:89-99 pubmed publisher
    ..miR-155 and BTLA expression were examined by real-time RT-PCR. Cell surface CD69 expression and IL-2 secretion were measured by ELISA and flowcytometry, respectively...
  60. Cibrian D, Sanchez Madrid F. CD69: from activation marker to metabolic gatekeeper. Eur J Immunol. 2017;47:946-953 pubmed publisher
    b>CD69 is a membrane-bound, type II C-lectin receptor. It is a classical early marker of lymphocyte activation due to its rapid appearance on the surface of the plasma membrane after stimulation...
  61. Arvind P, Jayashree S, Jambunathan S, Nair J, Kakkar V. Understanding gene expression in coronary artery disease through global profiling, network analysis and independent validation of key candidate genes. J Genet. 2015;94:601-10 pubmed
    ..Expression of EGR1/2/3, IL8, CXCL1, PTGS2, CD69, IFNG, FASLG, CCL4, CDC42, DDX58, NFKBID and NR4A2 genes were independently validated; EGR1/2/3 and IL8 showed >..
  62. Panigrahi G, Yadav A, Mandal P, Tripathi A, Das M. Immunomodulatory potential of Rhein, an anthraquinone moiety of Cassia occidentalis seeds. Toxicol Lett. 2016;245:15-23 pubmed publisher
    ..analysis revealed that Rhein exposure significantly down regulate the expression of CD3e, CD4, CD8, CD28, CD69 molecules in T-cells...
  63. Tjwa E, Zoutendijk R, van Oord G, Boeijen L, Reijnders J, van Campenhout M, et al. Similar frequencies, phenotype and activation status of intrahepatic NK cells in chronic HBV patients after long-term treatment with tenofovir disoproxil fumarate (TDF). Antiviral Res. 2016;132:70-5 pubmed publisher
    ..During the course of therapy, no modulation of the expression levels and frequencies of CD69, HLA-DR, NKG2A and NKG2D on liver NK cells were detected...
  64. Agraz Cibrian J, Segura Ortega J, Delgado Rizo V, Fafutis Morris M. Alterations in neutrophil extracellular traps is associated with the degree of decompensation of liver cirrhosis. J Infect Dev Ctries. 2016;10:512-7 pubmed publisher
    ..the release of NETs by means of fluorescence microscopy and fluorometry, while expression of activation markers (CD69, CD80, perforin, and CAP-18) was evaluated by flow cytometry...
  65. Shen R, Xu C, Li L, Zhang T, Qin X, Li J. [A study on early activation of T lymphocytes and soluble tumor necrosis factor receptor in patients with myelodysplastic syndrome]. Zhonghua Nei Ke Za Zhi. 2003;42:857-60 pubmed
    ..It is indicate that the increased early activation and activated potentials of T lymphocytes, along with abnormally elevated immunologically active molecules play an important role in immune pathogenesis of patients with MDS. ..
  66. Li J, Andreyev O, Chen M, Marco M, Iwase H, Long C, et al. Human T cells upregulate CD69 after coculture with xenogeneic genetically-modified pig mesenchymal stromal cells. Cell Immunol. 2013;285:23-30 pubmed publisher
    ..In contrast, CD69 expression was upregulated on T cells in response to both pMSC and pAEC, which was associated with a significant ..
  67. Li G, Ju J, Weyand C, Goronzy J. Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation. J Immunol. 2015;195:865-74 pubmed publisher
    ..The heightened STAT signaling is critical to maintain the expression of CD69 that regulates lymphocyte egress and the ability to produce IL-2 and to survive...
  68. Goulart C, Rodriguez D, Kanno A, Lu Y, Malley R, Leite L. Recombinant BCG expressing a PspA-PdT fusion protein protects mice against pneumococcal lethal challenge in a prime-boost strategy. Vaccine. 2017;35:1683-1691 pubmed publisher
    ..Furthermore, a higher expression of CD69 early activation molecule was observed on splenic CD4+ T cells from mice immunized with rBCG PspA-PdT ..
  69. Sega E, Leveson Gower D, Florek M, Schneidawind D, Luong R, Negrin R. Role of lymphocyte activation gene-3 (Lag-3) in conventional and regulatory T cell function in allogeneic transplantation. PLoS ONE. 2014;9:e86551 pubmed publisher
    ..as indicated by CFSE and bioluminescence imaging analyses and higher levels of activation markers such as CD69, CD107a, granzyme B, and Ki-67 as well as production of IL-10 and IFN-g early after transplantation...
  70. Tomkowicz B, Walsh E, Cotty A, Verona R, Sabins N, Kaplan F, et al. TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway. PLoS ONE. 2015;10:e0140694 pubmed publisher
    ..model, our results demonstrate that TIM-3 inhibits several TCR-mediated phenotypes: i) NF-kB/NFAT activation, ii) CD69 expression, and iii) suppression of IL-2 secretion...
  71. Raşid O, Ciulean I, Fitting C, Doyen N, Cavaillon J. Local Microenvironment Controls the Compartmentalization of NK Cell Responses during Systemic Inflammation in Mice. J Immunol. 2016;197:2444-54 pubmed publisher
    ..We report that, despite similar systemic dynamics of NK cell responses, expression of activation markers (CD69 and CD25) and effector molecules (IFN-?, granzyme B, and IL-10) display organ-specific thresholds of maximum ..
  72. Engmann J, Rüdrich U, Behrens G, Papakonstantinou E, Gehring M, Kapp A, et al. Increased Activity and Apoptosis of Eosinophils in Blister Fluids, Skin and Peripheral Blood of Patients with Bullous Pemphigoid. Acta Derm Venereol. 2017;97:464-471 pubmed publisher
    ..blister-derived eosinophils were strongly activated in patients with BP, seen by increased surface expression of CD69 compared with controls...
  73. Hosseini E, Ghasemzadeh M, Kamalizad M, Schwarer A. Ex vivo expansion of CD3depleted cord blood-MNCs in the presence of bone marrow stromal cells; an appropriate strategy to provide functional NK cells applicable for cellular therapy. Stem Cell Res. 2017;19:148-155 pubmed publisher
    ..UCB-MNCs in the presence of BMSCs and cytokines showed lower expression of CD3, CD19, CD14, CD15 and CD69 as well as higher expression of CD2 and CD7, which were suggestive of cell differentiation into mature NK cell ..
  74. Moslem M, Eberle I, Weber I, Henschler R, Cantz T. Mesenchymal Stem/Stromal Cells Derived from Induced Pluripotent Stem Cells Support CD34(pos) Hematopoietic Stem Cell Propagation and Suppress Inflammatory Reaction. Stem Cells Int. 2015;2015:843058 pubmed publisher
    ..cell proliferation, reduce proinflammatory cytokines in mixed lymphocyte reaction, and increase regulatory CD4(+)/CD69(+)/CD25(+) T-lymphocyte population...
  75. Yin S, Wu H, Song C, Chen X, Zhang Y. Modulation and the Underlying Mechanism of T Cells in Thymus of Mice by Oral Administration of Sodium Fluoride. Biol Trace Elem Res. 2016;170:194-200 pubmed publisher
    ..Expression of the T cell function-related genes CD2, PTPRC, CD69, and CD101, which are involved in thymic function in mice, decreased with the fluoride administration...
  76. Moore T, Wagner C, Scurti G, Hutchens K, Godellas C, Clark A, et al. Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells. Cancer Immunol Immunother. 2018;67:311-325 pubmed publisher
    ..Parameters monitored on transduced T cells included activation (CD25, CD69), inhibitory (PD-1, TIM-3, CTLA-4), costimulatory (OX40), and memory (CCR7) markers...
  77. Olesen R, Vigano S, Rasmussen T, Søgaard O, Ouyang Z, Buzon M, et al. Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat. J Virol. 2015;89:10176-89 pubmed publisher
    ..in HIV-1 DNA levels during panobinostat treatment were negatively associated with the corresponding changes in CD69(+) NK cells...
  78. Azad A, Yin Lim S, D Costa Z, Jones K, Diana A, Sansom O, et al. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO Mol Med. 2017;9:167-180 pubmed publisher
    ..T-cell infiltration with concomitant upregulation of T-cell activation markers including CD69, CD44, and FasL, and increased CD8:Treg ratio...
  79. Turner J, Becker M, Mittrücker H, Panzer U. Tissue-Resident Lymphocytes in the Kidney. J Am Soc Nephrol. 2018;29:389-399 pubmed publisher
    ..lymphocytes that are found in the kidney displays a surface phenotype suggestive of tissue residency, such as CD69+CD4+ T cells...
  80. Lichtenfels R, Rappl G, Hombach A, Recktenwald C, Dressler S, Abken H, et al. A proteomic view at T cell costimulation. PLoS ONE. 2012;7:e32994 pubmed publisher
    ..Therefore, comparative 2-DE-based proteome analyses of CD3(+) CD69(-) resting T cells versus cells incubated with (i) the agonistic anti-CD3 antibody OKT3 mimicking signal 1 in ..
  81. Nelson L, Mansfield J, Lloyd R, Oguejiofor K, Salih Z, Menasce L, et al. Automated prognostic pattern detection shows favourable diffuse pattern of FOXP3(+) Tregs in follicular lymphoma. Br J Cancer. 2015;113:1197-205 pubmed publisher
    ..A tissue microarray of 40 patient samples was used in triplex immunohistochemistry for FOXP3, CD3 and CD69, and multispectral imaging used to determine the numbers and locations of CD3(+), FOXP3/CD3(+) and CD69/CD3(+) T ..
  82. Hantschel O, Gstoettenbauer A, Colinge J, Kaupe I, Bilban M, Burkard T, et al. The chemokine interleukin-8 and the surface activation protein CD69 are markers for Bcr-Abl activity in chronic myeloid leukemia. Mol Oncol. 2008;2:272-81 pubmed publisher
    ..Among the strongest downregulated genes, we have further validated the activation marker CD69 and the chemokine interleukin (IL)-8...
  83. Hamann J, Fiebig H, Strauss M. Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain. J Immunol. 1993;150:4920-7 pubmed
    b>CD69 is a very early activation Ag of T lymphocytes. It is a cell surface glycoprotein that can only be detected after stimulation of lymphocytes...
  84. Jasinski Bergner S, Stoehr C, Bukur J, Massa C, Braun J, Hüttelmaier S, et al. Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma. Oncoimmunology. 2015;4:e1008805 pubmed
    ..frequency of CD3+/CD8+ T cell lymphocytes, but no differences in the activation markers CD69, CD25 or in the presence of CD56+, FoxP3+ and CD4+ immune cells were detected in ..
  85. Shenoy G, Loyall J, Maguire O, Iyer V, Kelleher R, Minderman H, et al. Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses. Cancer Immunol Res. 2018;6:236-247 pubmed publisher
    ..inhibit various activation endpoints including translocation of NFκB and NFAT into the nucleus, upregulation of CD69 and CD107a, production of cytokines, and cell proliferation...
  86. Wang X, Zhou Y, He S, Ouyang Z, Feng L, Shen Y, et al. Obaculactone exerts a novel ameliorating effect on contact dermatitis through regulating T lymphocyte. Int Immunopharmacol. 2015;28:1-9 pubmed publisher
    ..In addition, the enhanced expressions of CD25 and CD69 in activated T cells were reduced by obaculactone...
  87. Rölle A, Halenius A, Ewen E, Cerwenka A, Hengel H, Momburg F. CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection. Eur J Immunol. 2016;46:2420-2425 pubmed publisher
    ..In a co-culture system of human PBMCs and productively infected fibroblasts, we observed an upregulation of CD69, CD25, and HLA-DR on all NK cells...
  88. Martin P, Sanchez Madrid F. CD69: an unexpected regulator of TH17 cell-driven inflammatory responses. Sci Signal. 2011;4:pe14 pubmed publisher
    Mice lacking the C-type lectin receptor CD69 develop exacerbated forms of arthritis, contact dermatitis, allergic asthma, and autoimmune myocarditis...
  89. Diab M, Glasner A, Isaacson B, Bar On Y, Drori Y, Yamin R, et al. NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection. Eur J Immunol. 2017;47:692-703 pubmed publisher
    ..of HMPV-infected mice and found that lung NK cells are more activated and expressing NKG2D, CD43, CD27, KLRG1, and CD69 compared to blood NK cells regardless of HMPV infection...
  90. Ronsen O, Pedersen B, Øritsland T, Bahr R, Kjeldsen Kragh J. Leukocyte counts and lymphocyte responsiveness associated with repeated bouts of strenuous endurance exercise. J Appl Physiol (1985). 2001;91:425-34 pubmed
    ..monoclonal antibodies against CD2 and assessed by flow cytometry for expression of the early activation molecule CD69. The second bout of exercise in the Two trial was associated with significantly increased concentrations of total ..
  91. Chavez Rueda K, Legorreta Haquet M, Cervera Castillo H, Sanchez L, Jara L, Zenteno E, et al. Prolactin effect on CD69 and CD154 expression by CD4+ cells from systemic lupus erythematosus patients. Clin Exp Rheumatol. 2005;23:769-77 pubmed
    ..as a negative control, b) unspecific mitogen as a positive control (PMA-ionomycin for CD154 or concanavalin A for CD69), c) PRL alone, d) mitogen plus PRL, e) mitogen plus antibody anti-PRL (1:50) and f) mitogen plus an unrelated ..
  92. Das P, Grewal J, Chauhan V. Interaction of Plasmodium falciparum histidine-rich protein II with human lymphocytes leads to suppression of proliferation, IFN-gamma release, and CD69 expression. Parasitol Res. 2006;100:39-50 pubmed
    ..We found a reduction in IFN-gamma release in T cells preincubated with HRP II. HRP II also reduced the CD69 expression on the T cells...