Gene Symbol: CD64
Description: Fc fragment of IgG receptor Ia
Alias: CD64, CD64A, FCRI, IGFR1, high affinity immunoglobulin gamma Fc receptor I, Fc fragment of IgG, high affinity Ia, receptor (CD64), Fc fragment of IgG, high affinity Ia, receptor for (CD64), Fc gamma receptor Ia, Fc-gamma RI, Fc-gamma receptor I A1, IgG Fc receptor I, fc-gamma RIA, fcgammaRIa
Species: human
Products:     CD64

Top Publications

  1. Beekman J, Bakema J, van de Winkel J, Leusen J. Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity. Proc Natl Acad Sci U S A. 2004;101:10392-7 pubmed
    ..These data illustrate that intracellular protein interactions with a multisubunit FcR alpha-chain can confer unique properties to the receptor. ..
  2. Bang R, Marnell L, Mold C, Stein M, Clos K, Chivington Buck C, et al. Analysis of binding sites in human C-reactive protein for Fc{gamma}RI, Fc{gamma}RIIA, and C1q by site-directed mutagenesis. J Biol Chem. 2005;280:25095-102 pubmed
    ..goal of this study was to elucidate amino acid residues important for the interaction of CRP with human FcgammaRI (CD64) and FcgammaRIIa (CD32)...
  3. van der Meer W, Pickkers P, Scott C, Van Der Hoeven J, Gunnewiek J. Hematological indices, inflammatory markers and neutrophil CD64 expression: comparative trends during experimental human endotoxemia. J Endotoxin Res. 2007;13:94-100 pubmed
    b>CD64 is a high-affinity Fc(gamma)RI receptor expressed by activated neutrophils that has been recently evaluated as a potential sepsis parameter...
  4. Beekman J, van der Linden J, van de Winkel J, Leusen J. FcgammaRI (CD64) resides constitutively in lipid rafts. Immunol Lett. 2008;116:149-55 pubmed publisher
    ..We, here, study association between the high affinity IgG receptor, FcgammaRI (CD64), and membrane microdomains...
  5. Groselj Grenc M, Ihan A, Derganc M. Neutrophil and monocyte CD64 and CD163 expression in critically ill neonates and children with sepsis: comparison of fluorescence intensities and calculated indexes. Mediators Inflamm. 2008;2008:202646 pubmed publisher
    To evaluate the expression of CD64 and CD163 on neutrophils and monocytes in SIRS with/without sepsis and to compare the diagnostic accuracy of CD64 and CD163 molecules expression determined as (1) mean fluorescence intensities (MFI) of ..
  6. Delanghe J, Speeckaert M. Translational research and biomarkers in neonatal sepsis. Clin Chim Acta. 2015;451:46-64 pubmed publisher
    ..Several cell adhesion molecules contribute to the pathogenesis of sepsis. As an upregulated CD64 expression on granulocytes is found within 1-6h after bacterial invasion, serial CD64 measurements could guide ..
  7. Fueldner C, Kohlschmidt J, Riemschneider S, Schulze F, Zoldan K, Esser C, et al. Benzo(a)pyrene attenuates the pattern-recognition-receptor induced proinflammatory phenotype of murine macrophages by inducing IL-10 expression in an aryl hydrocarbon receptor-dependent manner. Toxicology. 2018;409:80-90 pubmed publisher
    ..increased the expression of major histocompatibility complex class II (MHC-II), CD14, Fcγ receptor I (FcγRI/CD64), or CD86, enhanced NO production and phagocytosis what may be beneficial for phagocytosis and killing of microbial ..
  8. Nie M, Wang Y, Lu Y, Yuan Y, Liu Y, Li X. Protective effects of fucoidan against hyperoxic lung injury via the ERK signaling pathway. Mol Med Rep. 2017;: pubmed publisher
    ..demonstrated that hyperoxia also increased the mRNA expression levels of cluster of differentiation (CD)68, F4/80, CD64 and CD19 in lung tissue, and induced lung morphological alterations...
  9. Tzekova N, Heinen A, Bunk S, Hermann C, Hartung H, Reipert B, et al. Immunoglobulins stimulate cultured Schwann cell maturation and promote their potential to induce axonal outgrowth. J Neuroinflammation. 2015;12:107 pubmed publisher
    ..We found that IVIG specifically bind to Schwann cells and detected CD64 Fc receptor expression on their surface...

More Information

Publications138 found, 100 shown here

  1. Howard J, Florentinus Mefailoski A, Bowden P, Trimble W, Grinstein S, Marshall J. OxLDL receptor chromatography from live human U937 cells identifies SYK(L) that regulates phagocytosis of oxLDL. Anal Biochem. 2016;513:7-20 pubmed publisher
    ..Anti SYK siRNA regulated oxLD engulfment in the context of serum factors and or SYK-L siRNA significantly inhibited engulfment of oxLDL microbeads, but not IgG microbeads. ..
  2. Qing X, Qing A, Ji P, French S, Mason H. Mixed phenotype (T/B/myeloid) extramedullary blast crisis as an initial presentation of chronic myelogenous leukemia. Exp Mol Pathol. 2018;104:130-133 pubmed publisher
    ..weak cytoplasmic myeloperoxidase, without co-expression of surface CD3, CD4, CD8, CD20, CD22, CD14, CD15, CD16 and CD64, consistent with blasts with mixed phenotype (T/B/myeloid)...
  3. Lay J, Peden D, Alexis N. Flow cytometry of sputum: assessing inflammation and immune response elements in the bronchial airways. Inhal Toxicol. 2011;23:392-406 pubmed publisher
    ..g. CD16, CD64, CD14, HLA-DR) that differentiated granulocytes from monocytes and macrophages...
  4. Genis S, Aris A, Kaur M, Cerri R. Effect of metritis on endometrium tissue transcriptome during puerperium in Holstein lactating cows. Theriogenology. 2018;122:116-123 pubmed publisher
    ..10), involved in endometrium remodeling, and a possible compensatory upregulation of its receptor IGFR1 (P < 0.05)...
  5. Beppler J, Koehler Santos P, Pasqualim G, Matte U, Alho C, Dias F, et al. Fc Gamma Receptor IIA (CD32A) R131 Polymorphism as a Marker of Genetic Susceptibility to Sepsis. Inflammation. 2016;39:518-25 pubmed publisher
    ..05). Our data indicate that FcγRIIA genotyping can be used as a marker of genetic susceptibility to sepsis. ..
  6. Brandsma A, Schwartz S, Wester M, Valley C, Blezer G, Vidarsson G, et al. Mechanisms of inside-out signaling of the high-affinity IgG receptor Fc?RI. Sci Signal. 2018;11: pubmed publisher
    ..Fc gamma receptor I (Fc?RI; CD64), the high-affinity receptor for immunoglobulin G (IgG), plays roles in inflammation, autoimmune responses, and ..
  7. Murphy M, Newby J, Butow P, Kirsten L, Allison K, Loughnan S, et al. iCanADAPT Early protocol: randomised controlled trial (RCT) of clinician supervised transdiagnostic internet-delivered cognitive behaviour therapy (iCBT) for depression and/or anxiety in early stage cancer survivors -vs- treatment as usual. BMC Cancer. 2017;17:193 pubmed publisher
    ..measures will include the Kessler 10 to measure general distress, the Fear of Cancer Recurrence Inventory (FCRI) to measure the specific fear of cancer recurrence and the Functional Assessment of Cancer Therapy, General Version ..
  8. Hirako I, Gallego Marin C, Ataide M, Andrade W, Gravina H, Rocha B, et al. DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14+ CD16+ CD64high CD32low Inflammatory Monocytes from Malaria Patients. MBio. 2015;6:e01605-15 pubmed publisher
    ..peripheral blood mononuclear cells from acute malaria patients was found to be a CD14(+) CD16 (FcγRIIIA)(+) CD64 (FcγRI)(high) CD32 (FcγRIIB)(low) monocyte subset...
  9. Venosa A, Katzen J, Tomer Y, Kopp M, Jamil S, Russo S, et al. Epithelial Expression of an Interstitial Lung Disease-Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice. J Immunol. 2019;202:2760-2771 pubmed publisher
    ..of collagenase-digested lung cells revealed a transient, early reduction in SiglecFhiCD11blowCD64hiCD11chi macrophages, countered by the sequential accumulation of SiglecFloCD11b<..
  10. Nandi P, Siddiqui M, Lala P. Restraint of Trophoblast Invasion of the Uterus by Decorin: Role in Pre-eclampsia. Am J Reprod Immunol. 2016;75:351-60 pubmed publisher
    ..were differentially mediated by binding of DCN to multiple tyrosine kinase receptors (TKR) including EGFR, IGFR1, and VEGFR2...
  11. Palamides P, Jodeleit H, Föhlinger M, Beigel F, Herbach N, Mueller T, et al. A mouse model for ulcerative colitis based on NOD-scid IL2R ?null mice reconstituted with peripheral blood mononuclear cells from affected individuals. Dis Model Mech. 2016;9:985-97 pubmed publisher
    ..Analysis of human leucocytes isolated from mouse spleen revealed an increase in frequencies of CD1a+, CD64+, CD163+ and TSLPR+ CD14+ monocytes, and antigen-experienced CD44+ CD4+ and CD8+ T-cells in response to ethanol...
  12. Zhou J, Feng G, Beeson J, Hogarth P, Rogerson S, Yan Y, et al. CD14(hi)CD16+ monocytes phagocytose antibody-opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so. BMC Med. 2015;13:154 pubmed publisher
    ..Blocking experiments showed that Fcγ receptor IIIa (CD16) but not Fcγ receptor IIa (CD32a) or Fcγ receptor I (CD64) was necessary for phagocytosis...
  13. Krishnan S, Chang A, Hodges J, Couraud P, Romero I, Weksler B, et al. Serotype O18 avian pathogenic and neonatal meningitis Escherichia coli strains employ similar pathogenic strategies for the onset of meningitis. Virulence. 2015;6:777-86 pubmed publisher
    ..Further, these strains also require FcγRI-α chain (CD64) and Ecgp96 as receptors for OmpA in macrophages and HCMEC/D3, respectively, to bind and enter these cells...
  14. Muñoz Cano R, Pascal M, Bartra J, Picado C, Valero A, Kim D, et al. Distinct transcriptome profiles differentiate nonsteroidal anti-inflammatory drug-dependent from nonsteroidal anti-inflammatory drug-independent food-induced anaphylaxis. J Allergy Clin Immunol. 2016;137:137-146 pubmed publisher
    ..Increased expression of the IgG receptor (CD64) in patients with LTP-A was mirrored by the presence of LTP-specific IgG1 and IgG3...
  15. Le L, Nyengaard J, Golas M, Sander B. Vectors for Expression of Signal Peptide-Dependent Proteins in Baculovirus/Insect Cell Systems and Their Application to Expression and Purification of the High-Affinity Immunoglobulin Gamma Fc Receptor I in Complex with Its Gamma Chain. Mol Biotechnol. 2018;60:31-40 pubmed publisher
    ..a model, we used our system to express and purify the engineered high-affinity immunoglobulin gamma Fc receptor I (CD64) in complex with its gamma subunit (?-chain)...
  16. Hong J, Lee Y, Lee C, Eo S, Kim S, Lee N, et al. Physicochemical and biological characterization of SB2, a biosimilar of Remicade® (infliximab). MAbs. 2017;9:364-382 pubmed publisher
    ..These analytical findings support that SB2 is similar to the RP and also provide confidence of biosimilarity in terms of clinical safety and efficacy...
  17. Sousa S, Brion R, Lintunen M, Kronqvist P, Sandholm J, Mönkkönen J, et al. Human breast cancer cells educate macrophages toward the M2 activation status. Breast Cancer Res. 2015;17:101 pubmed publisher
    ..Obtained macrophages were analyzed by flow cytometry (CD14, CD16, CD64, CD86, CD200R and CD163), ELISA (IL-6, IL-8, IL-10, monocyte colony stimulating factor M-CSF) and zymography (..
  18. Zuercher A, Spirig R, Baz Morelli A, Käsermann F. IVIG in autoimmune disease - Potential next generation biologics. Autoimmun Rev. 2016;15:781-5 pubmed publisher
    ..Safety considerations will be crucial in the evaluation of these new entities. In a different approach, mutant Fc fragments and monoclonal antibodies have been designed for blockade of the FcRn. ..
  19. Sogkas G, Rau E, Atschekzei F, Syed S, Schmidt R. The Pyrazole Derivative BTP2 Attenuates IgG Immune Complex-induced Inflammation. Inflammation. 2018;41:42-49 pubmed publisher
    ..Our findings indicate the involvement of SOCE in Fc?R-mediated responses in vitro and in vivo and suggest that BTP2-mediated inhibition of SOCE may have a therapeutic potential on IC-mediated autoimmunity. ..
  20. Wang J, Li J, Zhao Y, Yi W, Bian J, Wan X, et al. Up-regulation of programmed cell death 1 ligand 1 on neutrophils may be involved in sepsis-induced immunosuppression: an animal study and a prospective case-control study. Anesthesiology. 2015;122:852-63 pubmed publisher
    ..The percentages of CD11a, CD62L, and C-C chemokine receptor type 2 were lower, whereas the percentages of CD16 and CD64 were higher on PD-L1 neutrophils than on PD-L1 neutrophils...
  21. Magnusson S, Wennerberg E, Matt P, Lindqvist U, Kleinau S. Dysregulated Fc receptor function in active rheumatoid arthritis. Immunol Lett. 2014;162:200-6 pubmed publisher
    ..Prior the functional studies the monocytes were characterized of their FcγRI (CD64), II (CD32), IIb (CD32b) and III (CD16) expression as well as their cell surface bound IgG...
  22. Kim M, Copland A, Nayak K, Chandele A, Ahmed M, Zhang Q, et al. Plant-expressed Fc-fusion protein tetravalent dengue vaccine with inherent adjuvant properties. Plant Biotechnol J. 2017;: pubmed publisher
    ..of this IgG Fc receptor targeted vaccine candidate was demonstrated in transgenic mice expressing human Fc?RI/CD64, by induction of neutralising antibodies and evidence of cell-mediated immunity...
  23. Dovšak T, Ihan A, Didanovic V, Kansky A, Verdenik M, Hren N. Effect of surgery and radiotherapy on complete blood count, lymphocyte subsets and inflammatory response in patients with advanced oral cancer. BMC Cancer. 2018;18:235 pubmed publisher
    ..response markers (C-reactive protein, erythrocyte sedimentation rate, leukocyte count, expression of index CD64 and index CD163 on neutrophils and monocytes) were measured, statistically analysed and correlated with clinical ..
  24. Wagner A, Junginger J, Lemensieck F, Hewicker Trautwein M. Immunohistochemical characterization of gastrointestinal macrophages/phagocytes in dogs with inflammatory bowel disease (IBD) and non-IBD dogs. Vet Immunol Immunopathol. 2018;197:49-57 pubmed publisher
    ..and colon from dogs with IBD showed reduced Mϕ numbers with the exception of slightly increased numbers of CD64+ Mϕ...
  25. Burvenich I, Farrugia W, Liu Z, Makris D, King D, Gloria B, et al. Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions. Biochem J. 2018;475:2179-2190 pubmed publisher
    ..Structure-based design approaches should take into account the conformational plasticity of the Fc when engineering antibodies with optimal effector properties. ..
  26. Ballmann C, Denney T, Beyers R, Quindry T, Romero M, Amin R, et al. Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice. Am J Physiol Heart Circ Physiol. 2017;312:H128-H140 pubmed publisher
    ..markers including NF?B, TGF-?1, and F4/80 compared with Mdx/Utrn+/-; however, P-NF?B, P-IKB?, IKB?, CD64, and COX2 were similar between groups...
  27. Jodeleit H, Palamides P, Beigel F, Mueller T, Wolf E, Siebeck M, et al. Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model. J Transl Med. 2017;15:265 pubmed publisher
    ..Analysis of leukocytes isolated from the spleen of challenged NSG-UC mice corroborated CD64, CD163 and CD1a expressing CD14+ monocytes, CD1a expressing CD11b+ macrophages and HGF, TARC, IFNγ and TGFß1 mRNA ..
  28. Fujimura Y, Yamada K, Tachibana H. A lipid raft-associated 67kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on FcepsilonRI expression. Biochem Biophys Res Commun. 2005;336:674-81 pubmed
    ..Thus, these results suggest that the lipid raft-associated 67LR plays an important role in mediating the FcepsilonRI-suppressive action of EGCG. ..
  29. Fitrolaki D, Dimitriou H, Kalmanti M, Briassoulis G. CD64-Neutrophil expression and stress metabolic patterns in early sepsis and severe traumatic brain injury in children. BMC Pediatr. 2013;13:31 pubmed publisher
    ..and healthy controls (C) and to evaluate their relations to neutrophil, lymphocyte and monocyte expressions of CD64 and CD11b. Sixty children were enrolled in the study...
  30. Tan H, Yong Y, Shankar E, Paukovics G, Ellegård R, Larsson M, et al. Aberrant Inflammasome Activation Characterizes Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome. J Immunol. 2016;196:4052-63 pubmed publisher
    ..b>CD64(+) monocytes were a marker of increased casp1 expression...
  31. Chicard M, Boyault S, Colmet Daage L, Richer W, Gentien D, Pierron G, et al. Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma. Clin Cancer Res. 2016;22:5564-5573 pubmed publisher
    ..were seen by tumor aCGH, and 54 breakpoints were seen in cfDNA only, including two cases with interstitial IGFR1 gains and two alterations targeting TERT CONCLUSIONS: These results demonstrate the feasibility of cfDNA copy ..
  32. Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry N, et al. Splice variants as novel targets in pancreatic ductal adenocarcinoma. Sci Rep. 2017;7:2980 pubmed publisher
    ..We also collate a set of AS and DE genes encoding cell surface proteins, which present promising diagnostic and therapeutic targets in PDAC. ..
  33. Steinckwich N, Schenten V, Melchior C, Bréchard S, Tschirhart E. An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and Fc?R-mediated phagosomal oxidative activity. J Immunol. 2011;186:2182-91 pubmed publisher
    ..Then phagosomal ROS production requires extracellular Ca(2+) entry mediated by Orai1/STIM1 and relayed by S100A8-A9 as Ca(2+) sensor...
  34. Shi J, Zhang J, Wu Q, Li J. [Diagnostic Value of Neutrophil CD64 for Bacterial Infection in Patients with Hematologic Malignancies after Chemotherapy]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:852-5 pubmed publisher
    To investigate the value of CD64 mean fluorescence intensity of the peripheral blood neutrophils as a diagnostic marker of bacterial infection in patients with hematologic malignancies after chemotherapy...
  35. Minett T, Classey J, Matthews F, Fahrenhold M, Taga M, Brayne C, et al. Microglial immunophenotype in dementia with Alzheimer's pathology. J Neuroinflammation. 2016;13:135 pubmed publisher
    ..molecule (Iba1) (microglial motility), macrophage scavenger receptor (MSR)-A (plaque-related phagocytosis) and CD64 (immunoglobulin Fcγ receptor I)...
  36. Guo J, Jia J, Che W, Yuan W, Kong L. [Diagnostic Value of CD64+ Index of Neutrophils for Patients with Leukemia Combined with Early Infection]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1375-1378 pubmed publisher
    To analyze the diagnostic value of CD64+ index of neutrophils for patients with leukemia combined with early infection...
  37. Kawamura S, Onai N, Miya F, Sato T, Tsunoda T, Kurabayashi K, et al. Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs. Immunity. 2017;46:835-848.e4 pubmed publisher
    ..Here, we identified human cMoPs as a CLEC12AhiCD64hi subpopulation of conventional granulocyte-monocyte progenitors (cGMPs) in umbilical cord blood and in ..
  38. Iqbal J, Thike A, Cheok P, Tse G, Tan P. Insulin growth factor receptor-1 expression and loss of PTEN protein predict early recurrence in triple-negative breast cancer. Histopathology. 2012;61:652-9 pubmed publisher
    ..A high percentage of PTEN loss with overexpression of IGFR-1 and pAKT in TNBC indicates the potential of these molecules for predicting early recurrence and/or as targets in the formulation of effective alternative therapy regimens. ..
  39. Mosquera Restrepo S, Caro A, Peláez Jaramillo C, Rojas M. Mononuclear phagocyte accumulates a stearic acid derivative during differentiation into macrophages. Effects of stearic acid on macrophage differentiation and Mycobacterium tuberculosis control. Cell Immunol. 2016;303:24-33 pubmed publisher
    ..Exogenous stearic acid enhanced the expression of HLA-DR and CD64; there was also accumulation of IL-12, TNF-α, IL-6, MIP-1 α and β and a reduction in MCP-1 and the ..
  40. Tan T, Ahmad N, Nasuruddin D, Ithnin A, Tajul Arifin K, Zaini I, et al. CD64 and Group II Secretory Phospholipase A2 (sPLA2-IIA) as Biomarkers for Distinguishing Adult Sepsis and Bacterial Infections in the Emergency Department. PLoS ONE. 2016;11:e0152065 pubmed publisher
    ..Serum levels for Group II Secretory Phospholipase A2 (sPLA2-IIA) and CD64 were subsequently analyzed. Sepsis was confirmed in 42 patients from a total of 51 recruited subjects...
  41. Schmidt C, Aranda Lopez P, Dopheide J, Schmidt F, Theobald M, Schild H, et al. Phenotypic and functional characterization of neutrophils and monocytes from patients with myelodysplastic syndrome by flow cytometry. Cell Immunol. 2016;308:19-26 pubmed publisher
    ..Our data show a heterogeneous pattern for CD66, CD16 and CD64 expression on PMNs of MDS patients. CD62L shedding rate and CD66 degranulation were reduced...
  42. Lara S, Alnasser F, Polo E, Garry D, Lo Giudice M, Hristov D, et al. Identification of Receptor Binding to the Biomolecular Corona of Nanoparticles. ACS Nano. 2017;11:1884-1893 pubmed publisher
  43. Hayes J, Frostell A, Karlsson R, Muller S, Martin S, Pauers M, et al. Identification of Fc Gamma Receptor Glycoforms That Produce Differential Binding Kinetics for Rituximab. Mol Cell Proteomics. 2017;16:1770-1788 pubmed publisher
    ..a complete description of the glycan composition of Chinese hamster ovary (CHO) expressed human Fc? receptors RI (CD64), RIIaArg131/His131 (CD32a), RIIb (CD32b) and RIIIaPhe158/Val158 (CD16a) and analyze the role ..
  44. Jämsä J, Ala Kokko T, Huotari V, Ohtonen P, Savolainen E, Syrjala H. Neutrophil CD64, C-reactive protein, and procalcitonin in the identification of sepsis in the ICU - Post-test probabilities. J Crit Care. 2018;43:139-142 pubmed publisher
    ..PCT) distinguish sepsis from non-septic controls and whether a combination of CRP, PCT, and neutrophil CD64 improves identification of sepsis in the intensive care unit (ICU)...
  45. Alexis N, Soukup J, Nierkens S, Becker S. Association between airway hyperreactivity and bronchial macrophage dysfunction in individuals with mild asthma. Am J Physiol Lung Cell Mol Physiol. 2001;280:L369-75 pubmed
    ..sputum from mild asthmatics (n = 20) and healthy individuals (n = 20) were analyzed using flow cytometry for CD16, CD64, CD11b, CD14, and human leukocyte antigen-DR expression, phagocytosis of IgG opsonized yeast, and oxidant ..
  46. Korzycka Zaborowska B, Hopkin J, Gorski P. Genetic variants of FcepsilonRIbeta and Il-4 and atopy in a Polish population. Allergol Immunopathol (Madr). 2004;32:53-8 pubmed
    ..36) or (-590 C/T) Il-4 gene promoter polymorphism (OR = 0.88). The results suggest that FcRIint2 polymorphism is related to atopy and may influence its development. ..
  47. Rogina P, Stubljar D, Lejko Zupanc T, Osredkar J, Skvarc M. Expression of CD64 on neutrophils (CD64 index): diagnostic accuracy of CD64 index to predict sepsis in critically ill patients. Clin Chem Lab Med. 2015;53:e89-91 pubmed publisher
  48. Wu S, Yang S, Zhu L, Wang Y, Zhang Y, Zhou J, et al. Prognosis of Patients With de novo Acute Myeloid Leukemia Resistant to Initial Induction Chemotherapy. Am J Med Sci. 2016;351:473-9 pubmed publisher
    ..higher proportion of FLT3-ITD mutations, higher expression rates of CD9, lower expression rates of cMPO and CD64 and poorer overall survival (OS). The 2-year OS rate of the non-CR groups was inferior to that of the CR groups (28...
  49. Blázquez Moreno A, Park S, Im W, Call M, Call M, Reyburn H. Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules. Proc Natl Acad Sci U S A. 2017;114:E5645-E5654 pubmed publisher
    ..studies indicate that similar features underlie the association of other activating immune receptors, including CD64 and Fc?R1?, with signaling adaptor molecules, and we confirm experimentally that equivalent F, D, and T residues in ..
  50. Guo X, Kang Y, Guo S. [Comparison of Diagnosis Values of CD64 Infection Index, CRP, PCT and NEU% in the Leukemia Complicated with Bacterial Infection]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26:132-135 pubmed publisher
    To compare the diagnostic values of CD64 infection index, C-reactive protein (CRP), procalcitonin (PCT) and the percentage of neutrophils (NEU%) in leukemia patients complicated with bacterial infection...
  51. Hassan U, Zhu R, Bashir R. Multivariate computational analysis of biosensor's data for improved CD64 quantification for sepsis diagnosis. Lab Chip. 2018;18:1231-1240 pubmed publisher
    ..Changes in leukocyte counts and CD64 expression levels are known specific biomarkers of pro-inflammatory host response at the onset of sepsis...
  52. Wang A, Scholl P, Geha R. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. J Exp Med. 1994;180:1165-70 pubmed
    The high affinity immunoglobulin G (IgG) receptor Fc gamma RI (CD64) is expressed constitutively on monocytes and macrophages, and is inducible on neutrophils...
  53. Guyre C, Keler T, Swink S, Vitale L, Graziano R, Fanger M. Receptor modulation by Fc gamma RI-specific fusion proteins is dependent on receptor number and modified by IgG. J Immunol. 2001;167:6303-11 pubmed
    The high-affinity IgG receptor, FcgammaRI (CD64), is constitutively expressed exclusively on professional APCs. Human FcgammaRI binds monomeric IgG with high affinity and is, therefore, saturated in vivo...
  54. Lundberg K, Greiff L, Borrebaeck C, Lindstedt M. Fc?RI levels and frequencies of peripheral blood dendritic cell populations in allergic rhinitis. Hum Immunol. 2010;71:931-3 pubmed publisher
    ..Thus our data suggest that CD1c+ DCs influence allergen-specific immune responses. Research on their functional properties in allergy is warranted for development of future immunotherapies targeting specialized DC subsets. ..
  55. Lebel S, Simard S, Harris C, Feldstain A, Beattie S, McCallum M, et al. Empirical validation of the English version of the Fear of Cancer Recurrence Inventory. Qual Life Res. 2016;25:311-321 pubmed publisher
    ..One exception is the Fear of Cancer Recurrence Inventory (FCRI), originally developed and empirically validated in French...
  56. Föhlinger M, Palamides P, Mansmann U, Beigel F, Siebeck M, Gropp R. Immunological profiling of patients with ulcerative colitis leads to identification of two inflammatory conditions and CD1a as a disease marker. J Transl Med. 2016;14:310 pubmed
    ..An 'acute' condition characterized by adaptive immune cells as plasma cells,  TSLPR expressing CD11b+ macrophages, CD64 and CCR2 expressing CD14+ monocytes, HGF and TARC and a 'remodeling' condition signified by NK T-cells and TLSPR ..
  57. Zhang Y, Wang L, Wu Z, Yu X, Du X, Li X. The Expressions of Klotho Family Genes in Human Ocular Tissues and in Anterior Lens Capsules of Age-Related Cataract. Curr Eye Res. 2017;42:871-875 pubmed publisher
    ..reverse transcription was performed to detect the mRNA expressions of α-Klotho, β-Klotho, γ-Klotho, IGFR1, AKT, and ERK; Western blot analysis for detecting the expression of ERK1/2 and phosphor-ERK1/2 protein; and ..
  58. Weddell J, Imoukhuede P. Integrative meta-modeling identifies endocytic vesicles, late endosome and the nucleus as the cellular compartments primarily directing RTK signaling. Integr Biol (Camb). 2017;9:464-484 pubmed publisher
    ..the abundance of signaling from eight RTKs, identifying the following hierarchy in RTK signaling: PDGFRβ > IGFR1 > EGFR > PDGFRα > VEGFR1 > VEGFR2 > Tie2 > FGFR1...
  59. Drechsler Y, Chavan S, Catalano D, Mandrekar P, Szabo G. FcgammaR cross-linking mediates NF-kappaB activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development. J Leukoc Biol. 2002;72:657-67 pubmed
    ..These results suggest that signals mediated via FcgammaRI, -II, and -III have overlapping yet distinct effects on MO, which are likely to be involved in the fine-tuning of the immune responses to various stimuli. ..
  60. Lu J, Ellsworth J, Hamacher N, Oak S, Sun P. Crystal structure of Fcγ receptor I and its implication in high affinity γ-immunoglobulin binding. J Biol Chem. 2011;286:40608-13 pubmed publisher
  61. Pabois A, Pagie S, Gérard N, Laboisse C, Pattier S, Hulin P, et al. Notch signaling mediates crosstalk between endothelial cells and macrophages via Dll4 and IL6 in cardiac microvascular inflammation. Biochem Pharmacol. 2016;104:95-107 pubmed publisher
    ..We showed that endothelial Dll4 induces macrophage polarization into a pro-inflammatory fate (CD40(high)CD64(high)CD200R(low) HLA-DR(low)CD11b(low)) eliciting the production of IL-6...
  62. Ma Y, Saiyin Q. [Evaluation of nCD64 and CD14 Index as Diagnostic Markers for Hematologic Tumors Combined with Bacterial Infection]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1566-1570 pubmed publisher
    To explore the value of both CD64(nCD64 IND) and CD14 (CD14 IND) Index of peripheral blood neutrophils as the diagnostic markers of hematologic tumors combined with bacterial infection...
  63. Chen S, Yang Q, Liu J, Huang H, Shi M, Feng X. Tsc1 controls the development and function of alveolar macrophages. Biochem Biophys Res Commun. 2018;498:592-596 pubmed publisher
    ..Ablation of Tsc1 downregulated the expression of surface marker CD64 and SiglecF on AMs...
  64. Gorgani N, Altin J, Parish C. Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes. Int Immunol. 1999;11:1275-82 pubmed
    ..Thus HRG can interact with FcgammaRI on monocytes and block monomeric IgG binding, whereas when incorporated in IgG containing IC, HRG can enhance the uptake of IC by monocytes, probably via its heparan sulfate binding domain. ..
  65. Sutherland J, Loxton A, Haks M, Kassa D, Ambrose L, Lee J, et al. Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity. Clin Microbiol Infect. 2014;20:O230-8 pubmed publisher
    ..The most consistent classifier of active disease was FCGR1A (high-affinity IgG Fc receptor 1 (CD64)), which was the only marker expressed at significantly higher levels in participants with active TB than in those ..
  66. Burgos J, Los Arcos I, Álvarez de la Sierra D, Falco V, Aguilo A, Sanchez I, et al. Determination of neutrophil CD64 expression as a prognostic biomarker in patients with community-acquired pneumonia. Eur J Clin Microbiol Infect Dis. 2016;35:1411-6 pubmed publisher
    The expression of CD64 in neutrophils (nCD64) has shown utility in the diagnosis of sepsis...
  67. Leon P, He W, Mullarkey C, Bailey M, Miller M, Krammer F, et al. Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact. Proc Natl Acad Sci U S A. 2016;113:E5944-E5951 pubmed
    ..This concept might be broadly applicable for protective antibody responses to viral pathogens that have suitable receptors on effector cells. ..
  68. Su J, Zhou H, Liu X, Nilsson J, Fredrikson G, Zhao M. oxLDL antibody inhibits MCP-1 release in monocytes/macrophages by regulating Ca2+ /K+ channel flow. J Cell Mol Med. 2017;21:929-940 pubmed publisher
    ..Using blocking antibodies against Fc?RI (CD64), Fc?RIIB (CD32) and Fc?RIII (CD16), only CD32 blocking antibody was found to reverse the inhibitory effect of ..
  69. Wiener E, Abeyakoon O, Benchetrit G, Lyall M, Keler T, Rodeck C. Anti-HPA-1a-mediated platelet phagocytosis by monocytes in vitro and its inhibition by Fc gamma receptor (FcgammaR) reactive reagents. Eur J Haematol. 2003;70:67-74 pubmed
    ..Moreover, the findings indicate the use of H22 as an alternative to interavenous Ig (ivIg) in the management of FAIT/NAIT. ..
  70. Beekman J, Bakema J, van der Poel C, van der Linden J, van de Winkel J, Leusen J. Protein 4.1G binds to a unique motif within the Fc gamma RI cytoplasmic tail. Mol Immunol. 2008;45:2069-75 pubmed
    ..1G was identified to interact with the cytosolic tail of the high affinity IgG receptor, Fc gamma RI, in yeast two-hybrid screens. Proteins of the 4...
  71. Lin J, Kurilova S, Scott B, Bosworth E, Iverson B, Bailey E, et al. TIRF imaging of Fc gamma receptor microclusters dynamics and signaling on macrophages during frustrated phagocytosis. BMC Immunol. 2016;17:5 pubmed publisher
  72. Das L, Ide K, Tanaka A, Morimoto H, Shimizu S, Tanimine N, et al. Fc-gamma receptor 3A polymorphism predicts the incidence of urinary tract infection in kidney-transplant recipients. Hum Immunol. 2017;78:357-362 pubmed publisher
    ..In conclusion, our findings indicate that Fc?R SNPs are predisposing factors for UTIs after KT. This study provides a foundation for further prospective studies on a larger scale. ..
  73. Bharadwaj D, Mold C, Markham E, Du Clos T. Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis. J Immunol. 2001;166:6735-41 pubmed
    ..These results suggest that SAP may function in host defense. In addition, as SAP binds to chromatin, a major immunogen in systemic lupus erythematosus, it may provide a clearance mechanism for this Ag through FcgammaR bearing cells. ..
  74. Bakema J, de Haij S, Den Hartog Jager C, Bakker J, Vidarsson G, van Egmond M, et al. Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction. J Immunol. 2006;176:3603-10 pubmed
    ..This suggests the involvement of additional amino acids in the FcalphaRI-FcR gamma-chain interaction. ..
  75. Kobayashi R, Okamura S, Ohno T, Saito H, Mori M, Ra C, et al. Hyperexpression of FcgammaRI and Toll-like receptor 4 in the intestinal mast cells of Crohn's disease patients. Clin Immunol. 2007;125:149-58 pubmed
    ..Hyperexpression of FcgammaRI and TLR4 on MCs was related to the high frequency of TNF-alpha expression in CD, suggesting the activation of MCs via these receptors in vivo. ..
  76. Baudino L, Shinohara Y, Nimmerjahn F, Furukawa J, Nakata M, Martinez Soria E, et al. Crucial role of aspartic acid at position 265 in the CH2 domain for murine IgG2a and IgG2b Fc-associated effector functions. J Immunol. 2008;181:6664-9 pubmed
    ..Thus, our results demonstrate that aspartic acid at position 265 is a residue critically implicated in triggering the Fc-associated effector functions of IgG, probably by defining a crucial three-dimensional structure of the Fc region. ..
  77. Corrales Aguilar E, Trilling M, Reinhard H, Merc Maldonado E, Widera M, Schaal H, et al. A novel assay for detecting virus-specific antibodies triggering activation of Fc? receptors. J Immunol Methods. 2013;387:21-35 pubmed publisher
    ..This assay will be instrumental for defining novel correlates of IgG immunity and the design of new therapeutic IgGs...
  78. Kustiawan I, Derksen N, Rispens T. Inactivated pepsin inhibits neutrophil activation by Fcgamma-receptor-dependent and independent stimuli. Clin Immunol. 2016;169:85-88 pubmed publisher
    ..The amounts of pepsin detected in three different pepsin-treated IVIg products were found to be too low to induce an effect, at least in an in vitro setting. ..
  79. Pauls S, Marshall A. Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target. Eur J Immunol. 2017;47:932-945 pubmed publisher
    ..Lastly, we discuss the biological activities, therapeutic promise, and limitations of small molecule modulators of SHIP enzymatic activity...
  80. Manukyan G, Papajik T, Gajdos P, Mikulkova Z, Urbanová R, Gabcova G, et al. Neutrophils in chronic lymphocytic leukemia are permanently activated and have functional defects. Oncotarget. 2017;8:84889-84901 pubmed publisher
    ..The percentage of CD54+ and CD64+ neutrophils as well as CD54 expression on these cells were higher in CLL patients than in age-matched healthy ..
  81. Ernst L, van de Winkel J, Chiu I, Anderson C. Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. J Biol Chem. 1992;267:15692-700 pubmed
    Three distinct but closely related classes of receptors that bind the Fc portion of immunoglobulin G (Fc gamma RI, -II, and -III) have been identified in humans...
  82. Porges A, Redecha P, Doebele R, Pan L, Salmon J, Kimberly R. Novel Fc gamma receptor I family gene products in human mononuclear cells. J Clin Invest. 1992;90:2102-9 pubmed
    ..RIII families, which exhibit considerable diversity at both the nucleic acid and protein levels, the human Fc gamma RI family has only a single recognized product expressed as a 70-kD cell surface receptor with high affinity for ..
  83. Kim M, Pan X, Huang Z, Hunter S, Hwang P, Indik Z, et al. Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis. Clin Immunol. 2001;98:125-32 pubmed
    ..We have demonstrated that members of each of the three classes of human Fc gamma receptors, Fc gamma RI, Fc gamma RII, and Fc gamma RIII, mediate phagocytosis, but that important differences exist in their ..
  84. Wang W, Soriano B, Chen Q. Glycan profiling of proteins using lectin binding by Surface Plasmon Resonance. Anal Biochem. 2017;538:53-63 pubmed publisher
    ..Hence, we demonstrated that SPR lectin binding analysis can be a quick alternative method to profile protein glycosylation. ..
  85. He W, Chen C, Mullarkey C, Hamilton J, Wong C, Leon P, et al. Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. Nat Commun. 2017;8:846 pubmed publisher
    ..Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protection. ..
  86. Pearse R, Feinman R, Ravetch J. Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements. Proc Natl Acad Sci U S A. 1991;88:11305-9 pubmed
    Expression of the high-affinity receptor for IgG (Fc gamma RI) is restricted to cells of myeloid lineage and is induced by gamma-interferon (IFN-gamma) but not by IFN-alpha/beta...
  87. Fanger N, Cosman D, Peterson L, Braddy S, Maliszewski C, Borges L. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur J Immunol. 1998;28:3423-34 pubmed
    ..Coligation of either LIR with Fcgamma receptor I (CD64) inhibits tyrosine phosphorylation of the associated Fc receptor gamma chain and Syk molecules, as well as ..
  88. Pawlik A, Florczak M, Bak L, Dabrowska Zamojcin E, Rozanski J, Domanski L, et al. The FcgammaRIIa polymorphism in patients with chronic kidney graft rejection. Transplant Proc. 2004;36:1311-3 pubmed
    ..The results suggest that the FcgammaRIIa polymorphism is not an important genetic risk factor for chronic rejection of kidney allografts. ..
  89. Karlberg M, Xiang Z, Nilsson G. Fc gamma RI-mediated activation of human mast cells promotes survival and induction of the pro-survival gene Bfl-1. J Clin Immunol. 2008;28:250-5 pubmed
    ..These data suggests that activation through Fc-receptors contribute to mast cell survival during antibody-dependent mast cell mediated inflammatory responses. ..
  90. Li Y, Lee P, Sobel E, Narain S, Satoh M, Segal M, et al. Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus. Arthritis Res Ther. 2009;11:R6 pubmed publisher
    The high-affinity receptor for IgG Fcgamma/CD64 is critical for the development of lupus nephritis (LN)...
  91. Jung S, Reddy S, Kang T, Borrok M, Sandlie I, Tucker P, et al. Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells. Proc Natl Acad Sci U S A. 2010;107:604-9 pubmed publisher
    ..a novel bacterial display/flow cytometric library screening system we isolated Fc variants that bind to FcgammaRI (CD64) with nanomolar affinity...
  92. Forthal D, Landucci G, Ding H, Kappes J, Wang A, Thung I, et al. IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation. AIDS. 2011;25:2099-104 pubmed publisher
    ..Vaccine-induced IgG2 may adversely affect a potentially important antiviral antibody activity, and altering Env glycans might provide the means to bias the subclass response in a favorable direction. ..