CD63

Summary

Gene Symbol: CD63
Description: CD63 molecule
Alias: LAMP-3, ME491, MLA1, OMA81H, TSPAN30, CD63 antigen, CD63 antigen (melanoma 1 antigen), granulophysin, lysosomal-associated membrane protein 3, lysosome-associated membrane glycoprotein 3, melanoma-associated antigen ME491, melanoma-associated antigen MLA1, ocular melanoma-associated antigen, tetraspanin-30, tspan-30
Species: human
Products:     CD63

Top Publications

  1. Yi L, Rosales T, Rose J, Chowdhury B, Chaudhury B, Knutson J, et al. HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking. J Biol Chem. 2010;285:30884-905 pubmed publisher
    ..In all, our data support a model for Nef down-regulation of HLA-I that involves both major trafficking itineraries and persistent protein-protein interactions throughout the cell...
  2. Raposo G, Moore M, Innes D, Leijendekker R, Leigh Brown A, Benaroch P, et al. Human macrophages accumulate HIV-1 particles in MHC II compartments. Traffic. 2002;3:718-29 pubmed
    ..multivesicular compartments which were enriched in major histocompatibility complex class II molecules and CD63. These features are characteristics of major histocompatibility complex class II compartments where maturing class ..
  3. Yoshida T, Kawano Y, Sato K, Ando Y, Aoki J, Miura Y, et al. A CD63 mutant inhibits T-cell tropic human immunodeficiency virus type 1 entry by disrupting CXCR4 trafficking to the plasma membrane. Traffic. 2008;9:540-58 pubmed publisher
    We have discovered that an N-terminal deletion mutant of a membrane protein, CD63, (CD63DeltaN) blocks entry of CXCR4-using, T-cell tropic human immunodeficiency virus type 1 (X4 HIV-1) by suppressing CXCR4 surface expression...
  4. Sato K, Aoki J, Misawa N, Daikoku E, Sano K, Tanaka Y, et al. Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins. J Virol. 2008;82:1021-33 pubmed
    ..Among these host proteins, we found that CD63 was eliminated from the plasma membranes of HIV-1-producing T cells after activation, followed by a decrease in the ..
  5. Jolly C, Sattentau Q. Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domains. J Virol. 2007;81:7873-84 pubmed
    ..The HIV-1 envelope glycoprotein (Env) and the core protein (Gag) colocalize strongly with CD63 and CD81 and less strongly with CD9, whereas no colocalization was seen between Env or Gag and the late endosome/..
  6. Mantegazza A, Barrio M, Moutel S, Bover L, Weck M, Brossart P, et al. CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells. Blood. 2004;104:1183-90 pubmed
    ..We show that CD63, CD9, CD81, CD82, and CD151 are present in immature DCs...
  7. Booth A, Fang Y, Fallon J, Yang J, Hildreth J, Gould S. Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J Cell Biol. 2006;172:923-35 pubmed
    ..In support of this, we find that Jurkat T cells direct the key budding factor of HIV, HIV Gag, to these endosome-like domains of plasma membrane and secrete HIV Gag from the cell in exosomes. ..
  8. Caby M, Lankar D, Vincendeau Scherrer C, Raposo G, Bonnerot C. Exosomal-like vesicles are present in human blood plasma. Int Immunol. 2005;17:879-87 pubmed
    ..identified by electron microscopy after isolation by differential ultracentrifugation or immunoisolation with CD63-coated latex beads...
  9. Lindwasser O, Resh M. Human immunodeficiency virus type 1 Gag contains a dileucine-like motif that regulates association with multivesicular bodies. J Virol. 2004;78:6013-23 pubmed
    ..Moreover, wild-type Gag, but not the internalization-defective mutation, can be induced to accumulate within CD63-positive MVBs by treatment of cells with U18666A, a drug that redistributes cholesterol from the plasma membrane to ..

More Information

Publications78

  1. Nydegger S, Khurana S, Krementsov D, Foti M, Thali M. Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1. J Cell Biol. 2006;173:795-807 pubmed
    ..Here, we reveal the presence of tetraspanin-enriched microdomains (TEMs) containing the tetraspanins CD9, CD63, CD81, and CD82 at the plasma membrane...
  2. Heijnen H, Van Lier M, Waaijenborg S, Ohno Iwashita Y, Waheed A, Inomata M, et al. Concentration of rafts in platelet filopodia correlates with recruitment of c-Src and CD63 to these domains. J Thromb Haemost. 2003;1:1161-73 pubmed
    ..raft aggregation was accompanied by concentration of the tyrosine kinase c-Src and the tetraspanin CD63 in these domains, whereas glycoprotein Ib (GPIb) was not selectively targeted to the raft clusters...
  3. Ageberg M, Lindmark A. Characterisation of the biosynthesis and processing of the neutrophil granule membrane protein CD63 in myeloid cells. Clin Lab Haematol. 2003;25:297-306 pubmed
    The biosynthesis and processing of the neutrophil granule membrane protein CD63, present in azurophil granules, was investigated in four myeloid cell lines...
  4. Duffield A, Kamsteeg E, Brown A, Pagel P, Caplan M. The tetraspanin CD63 enhances the internalization of the H,K-ATPase beta-subunit. Proc Natl Acad Sci U S A. 2003;100:15560-5 pubmed
    The tetraspanin CD63 resides in late endosomes, lysosomes, secretory vesicles, and at the plasma membrane, and it moves among these compartments...
  5. Metzelaar M, Wijngaard P, Peters P, Sixma J, Nieuwenhuis H, Clevers H. CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. J Biol Chem. 1991;266:3239-45 pubmed
    To clone the CD63 antigen, originally described as a blood platelet activation marker, we adapted the expression cloning procedure of Seed and Aruffo (Seed, B., and Aruffo, A. (1987) Proc. Natl. Acad. Sci. U.S. A...
  6. Grigorov B, Attuil Audenis V, Perugi F, Nedelec M, Watson S, Pique C, et al. A role for CD81 on the late steps of HIV-1 replication in a chronically infected T cell line. Retrovirology. 2009;6:28 pubmed publisher
    ..directly or indirectly, with CD81, and less with CD82, in tetraspanin-enriched microdomains composed of CD81/CD82/CD63. In addition, when HIV-1 producing cells were treated with anti-CD81 antibodies, or upon CD81 silencing by RNA ..
  7. Logozzi M, De Milito A, Lugini L, Borghi M, Calabro L, Spada M, et al. High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. PLoS ONE. 2009;4:e5219 pubmed publisher
    ..sandwich ELISA (Exotest) to capture and quantify exosomes in plasma based on expression of housekeeping proteins (CD63 and Rab-5b) and a tumor-associated marker (caveolin-1)...
  8. Weng J, Krementsov D, Khurana S, Roy N, Thali M. Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells. J Virol. 2009;83:7467-74 pubmed publisher
    ..Overall, these data establish tetraspanins as negative regulators of HIV-1-induced cell-cell fusion, and they start delineating the requirements for this regulation. ..
  9. Krementsov D, Rassam P, Margeat E, Roy N, Schneider Schaulies J, Milhiet P, et al. HIV-1 assembly differentially alters dynamics and partitioning of tetraspanins and raft components. Traffic. 2010;11:1401-14 pubmed
    ..Importantly, our findings support the emerging concept that cellular and viral components, instead of clustering at preexisting microdomain platforms, direct the formation of distinct domains for the execution of specific functions. ..
  10. Radford K, Thorne R, Hersey P. CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. Biochem Biophys Res Commun. 1996;222:13-8 pubmed
    b>CD63 belongs to the Transmembrane 4 superfamily (TM4SF) of membrane proteins whose functions are largely unknown. Previous results have suggested that CD63 may play an important role in the regulation of melanoma progression...
  11. Berditchevski F, Tolias K, Wong K, Carpenter C, Hemler M. A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J Biol Chem. 1997;272:2595-8 pubmed
    ..and immunochemical assays show a phosphatidylinositol 4-kinase in novel and specific complexes with proteins (CD63 and CD81) of the transmembrane 4 superfamily (TM4SF) and an integrin (alpha3beta1)...
  12. Rous B, Reaves B, Ihrke G, Briggs J, Gray S, Stephens D, et al. Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes. Mol Biol Cell. 2002;13:1071-82 pubmed
    b>CD63 is a lysosomal membrane protein that belongs to the tetraspanin family. Its carboxyterminal cytoplasmic tail sequence contains the lysosomal targeting motif GYEVM...
  13. Pelchen Matthews A, Kramer B, Marsh M. Infectious HIV-1 assembles in late endosomes in primary macrophages. J Cell Biol. 2003;162:443-55 pubmed
    ..Immunolabeling demonstrated that these compartments contained the late endosomal marker CD63, which was enriched on vesicles within these structures and incorporated into the envelope of budding virions...
  14. Hotta H, Ross A, Huebner K, Isobe M, Wendeborn S, Chao M, et al. Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. Cancer Res. 1988;48:2955-62 pubmed
    The melanoma-associated antigen ME491 is expressed strongly during the early stages of tumor progression...
  15. Charrin S, Le Naour F, Silvie O, Milhiet P, Boucheix C, Rubinstein E. Lateral organization of membrane proteins: tetraspanins spin their web. Biochem J. 2009;420:133-54 pubmed publisher
  16. Perugi F, Muriaux D, Ramirez B, Chabani S, Decroly E, Darlix J, et al. Human Discs Large is a new negative regulator of human immunodeficiency virus-1 infectivity. Mol Biol Cell. 2009;20:498-508 pubmed publisher
    ..Dlg1 knockdown is also associated with the redistribution and colocalization of Gag and Env toward CD63 and CD82 positive vesicle-like structures, including structures that seem to still be connected to the plasma ..
  17. Chen H, Dziuba N, Friedrich B, Von Lindern J, Murray J, Rojo D, et al. A critical role for CD63 in HIV replication and infection of macrophages and cell lines. Virology. 2008;379:191-6 pubmed publisher
    ..We previously demonstrated a role for CD63 in early HIV infection events in macrophages via inhibition by anti-CD63 antibody pretreatment...
  18. Gousset K, Ablan S, Coren L, Ono A, Soheilian F, Nagashima K, et al. Real-time visualization of HIV-1 GAG trafficking in infected macrophages. PLoS Pathog. 2008;4:e1000015 pubmed publisher
    ..These data indicate that a population of Gag in infected macrophages remains sequestered internally and is presented to uninfected target cells at a virological synapse. ..
  19. Ruiz Mateos E, Pelchen Matthews A, Deneka M, Marsh M. CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophages. J Virol. 2008;82:4751-61 pubmed publisher
    During the assembly of human immunodeficiency virus type 1 (HIV-1) particles, the tetraspanin CD63 can be incorporated into the viral membrane...
  20. Turville S, Aravantinou M, Stössel H, Romani N, Robbiani M. Resolution of de novo HIV production and trafficking in immature dendritic cells. Nat Methods. 2008;5:75-85 pubmed
  21. Chertova E, Chertov O, Coren L, Roser J, Trubey C, Bess J, et al. Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages. J Virol. 2006;80:9039-52 pubmed
    ..MDM-derived HIV contained 26 of 37 proteins previously found in exosomes, consistent with the idea that HIV uses the late endosome/multivesicular body pathway during virion budding from macrophages. ..
  22. Latysheva N, Muratov G, Rajesh S, Padgett M, Hotchin N, Overduin M, et al. Syntenin-1 is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63. Mol Cell Biol. 2006;26:7707-18 pubmed
    ..protein, as a new component of TERM and show that syntenin-1 specifically interacts with the tetraspanin CD63. Detailed biochemical and heteronuclear magnetic resonance spectroscopy (NMR) studies have demonstrated that the ..
  23. Perlman M, Resh M. Identification of an intracellular trafficking and assembly pathway for HIV-1 gag. Traffic. 2006;7:731-45 pubmed
    ..We propose that the regulation of Gag association with MVB-like compartments regulates the site of HIV-1 budding and particle formation. ..
  24. von Lindern J, Rojo D, Grovit Ferbas K, Yeramian C, Deng C, Herbein G, et al. Potential role for CD63 in CCR5-mediated human immunodeficiency virus type 1 infection of macrophages. J Virol. 2003;77:3624-33 pubmed
    ..of HIV-1 infection of macrophages by monoclonal antibody (MAb) to the tetraspan transmembrane glycoprotein CD63. Pretreatment of primary macrophages with anti-CD63 MAb, but not MAbs to other macrophage cell surface tetraspanins ..
  25. Ono A, Freed E. Cell-type-dependent targeting of human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular body. J Virol. 2004;78:1552-63 pubmed
    ..and T cells, the MA mutant Gag proteins that are defective in plasma membrane targeting form virus particles in a CD63-positive compartment, defined as the late endosome or multivesicular body (MVB)...
  26. Grigorov B, Arcanger F, Roingeard P, Darlix J, Muriaux D. Assembly of infectious HIV-1 in human epithelial and T-lymphoblastic cell lines. J Mol Biol. 2006;359:848-62 pubmed
  27. Gruenberg J. The endocytic pathway: a mosaic of domains. Nat Rev Mol Cell Biol. 2001;2:721-30 pubmed
    ..Whereas some of these molecular assemblies can be found in more than one compartment, a given combination seems to be unique to each compartment, indicating that membrane organization might be modular. ..
  28. Claas C, Stipp C, Hemler M. Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts. J Biol Chem. 2001;276:7974-84 pubmed
    ..show that prototype complexes of CD9 or CD81 (TM4SF proteins) with alpha(3)beta(1) (an integrin) and complexes of CD63 (a TM4SF protein) with phosphatidylinositol 4-kinase (PtdIns 4-K) may indeed localize within lipid raft-like ..
  29. Li G, Dziuba N, Friedrich B, Murray J, Ferguson M. A post-entry role for CD63 in early HIV-1 replication. Virology. 2011;412:315-24 pubmed publisher
    Macrophages and CD4(+) lymphocytes are the major reservoirs for HIV-1 infection. CD63 is a tetraspanin transmembrane protein, which has been shown to play an essential role during HIV-1 replication in macrophages...
  30. Nguyen D, Hildreth J. Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts. J Virol. 2000;74:3264-72 pubmed
  31. Rudnicka D, Feldmann J, Porrot F, Wietgrefe S, Guadagnini S, Prevost M, et al. Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses. J Virol. 2009;83:6234-46 pubmed publisher
    ..proteins often adopt a ring-like supramolecular organization at sites of intercellular contacts and colocalize with CD63 tetraspanin and raft components GM1, Thy-1, and CD59...
  32. Berditchevski F. Complexes of tetraspanins with integrins: more than meets the eye. J Cell Sci. 2001;114:4143-51 pubmed
  33. Chen Z, Mustafa T, Trojanowicz B, Brauckhoff M, Gimm O, Schmutzler C, et al. CD82, and CD63 in thyroid cancer. Int J Mol Med. 2004;14:517-27 pubmed
    CD82 (KAI1) and CD63 (ME491) are highly glycosylated proteins which belong to the transmembrane 4 superfamily (TM4SF)...
  34. Sincock P, Mayrhofer G, Ashman L. Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin. J Histochem Cytochem. 1997;45:515-25 pubmed
    It has recently been shown that several members of the tetraspan superfamily, including CD9 and CD63, associate with each other and with beta1 integrins...
  35. Escola J, Kleijmeer M, Stoorvogel W, Griffith J, Yoshie O, Geuze H. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem. 1998;273:20121-7 pubmed
    ..exosomes are enriched in the co-stimulatory molecule CD86 and in several tetraspan proteins, including CD37, CD53, CD63, CD81, and CD82...
  36. Welsch S, Keppler O, Habermann A, Allespach I, Krijnse Locker J, Kräusslich H. HIV-1 buds predominantly at the plasma membrane of primary human macrophages. PLoS Pathog. 2007;3:e36 pubmed
    ..Thus, contrary to current opinion, the plasma membrane is the primary site of HIV-1 budding also in infected macrophages. ..
  37. Jung K, Liu X, Chirco R, Fridman R, Kim H. Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. EMBO J. 2006;25:3934-42 pubmed
    This study identified CD63, a member of the tetraspanin family, as a TIMP-1 interacting protein by yeast two-hybrid screening...
  38. Niu Z, Pang R, Liu W, Li Q, Cheng R, Yeung W. Polymer-based precipitation preserves biological activities of extracellular vesicles from an endometrial cell line. PLoS ONE. 2017;12:e0186534 pubmed publisher
    ..05). All the isolated EVs expressed exosome-enriched proteins CD63, TSG101 and HSP70...
  39. Canfrán Duque A, Pastor O, Reina M, Lerma M, Cruz Jentoft A, Lasunción M, et al. Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. PLoS ONE. 2015;10:e0141829 pubmed publisher
    ..microscopy, and stimulated the release of lysosomal β-hexosaminidase and exosome markers flotillin-2 and CD63 into the media...
  40. Carmo L, Bonjour K, Ueki S, Neves J, Liu L, Spencer L, et al. CD63 is tightly associated with intracellular, secretory events chaperoning piecemeal degranulation and compound exocytosis in human eosinophils. J Leukoc Biol. 2016;100:391-401 pubmed publisher
    ..b>CD63, a member of the transmembrane-4 glycoprotein superfamily (tetraspanins) and present on the limiting membranes of ..
  41. Lai X, Chen S. Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma. Cancer Genomics Proteomics. 2015;12:271-81 pubmed
    ..A comprehensive approach to prioritize the biomarker candidates by category and rank revealed CD63, DDB1, TYMP, VDAC2, and DCXR as the top five biomarker candidates...
  42. Shames S, Deng W, Guttman J, de Hoog C, Li Y, Hardwidge P, et al. The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling. Cell Microbiol. 2010;12:1322-39 pubmed publisher
    ..This study provides evidence that EspZ and CD98 promote host cell survival mechanisms involving FAK during A/E pathogen infection. ..
  43. Li F, Wang Y, Lin L, Wang J, Xiao H, Li J, et al. Mast Cell-Derived Exosomes Promote Th2 Cell Differentiation via OX40L-OX40 Ligation. J Immunol Res. 2016;2016:3623898 pubmed publisher
    ..Further, bone marrow-derived mast cells (BMMCs) constitutively release exosomes, which express CD63 and OX40L. BMMC-exosomes partially promoted the proliferation of CD4(+) T cells...
  44. Habachi Houimli Y, Khalfallah Y, Makni H, Makni M, Bouktila D. Large-scale bioinformatic analysis of the regulation of the disease resistance NBS gene family by microRNAs in Poaceae. C R Biol. 2016;339:347-56 pubmed publisher
    ..Rpm1, Xa1 and Rps2), and 13 groups of resistance to fungi (Rpp8,13, Rp3, Tsn1, Lr10, Rps1-k-1, Pm3, Rpg5, and MLA1,6,10,12,13)...
  45. Raap U, Gehring M, Kleiner S, Rüdrich U, Eiz Vesper B, Haas H, et al. Human basophils are a source of - and are differentially activated by - IL-31. Clin Exp Allergy. 2017;47:499-508 pubmed publisher
    ..Basophil responses to IL-31 were assessed for chemotaxis, externalization of CD63 and CD203c as well as the release of histamine, IL-4 and IL-13. IL-31RA and OSMR were expressed on human basophils...
  46. Giavina Bianchi P, Galvão V, Picard M, Caiado J, Castells M. Basophil Activation Test is a Relevant Biomarker of the Outcome of Rapid Desensitization in Platinum Compounds-Allergy. J Allergy Clin Immunol Pract. 2017;5:728-736 pubmed publisher
    ..The basophil activation test (BAT) has been used in DHRs as a diagnostic tool. We evaluated basophil CD63 and CD203c expression (BAT) as a biomarker to assess the safety and effectiveness of RDD in platinum compounds-..
  47. Arenaccio C, Chiozzini C, Columba Cabezas S, Manfredi F, Affabris E, Baur A, et al. Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism. J Virol. 2014;88:11529-39 pubmed publisher
    ..Overall, our findings support the idea that HIV evolved to usurp the exosome-based intercellular communication network to favor its spread in infected hosts. ..
  48. Gorelik M, Narisety S, Guerrerio A, Chichester K, Keet C, Bieneman A, et al. Suppression of the immunologic response to peanut during immunotherapy is often transient. J Allergy Clin Immunol. 2015;135:1283-92 pubmed publisher
    ..Spontaneous and allergen-induced basophil reactivity (histamine release, CD63 expression, and IL-4 production) were suppressed during dose escalation and after 6 months of maintenance dosing...
  49. Mommert S, Kleiner S, Gehring M, Eiz Vesper B, Stark H, Gutzmer R, et al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016;71:1264-73 pubmed publisher
    ..Migration of basophils was assessed using the modified Boyden chamber technique. The expression levels of CD63 and CD203c on the cell surface and the sulfidoleukotriene release were determined by flow cytometry and ELISA, ..
  50. Yang C, Guo W, Zhang W, Bian J, Yang J, Qi T, et al. [Extraction and identification of semen-derived exosomes using PEG6000]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:1531-1535 pubmed
    ..The pellets expressed CD63, ALIX and TSG101 molecules but not calnexin that was expressed in sperm cells...
  51. Kang M, Ryu J, Lee D, Lee M, Kim H, Nam S, et al. Correlations between transmembrane 4 L6 family member 5 (TM4SF5), CD151, and CD63 in liver fibrotic phenotypes and hepatic migration and invasive capacities. PLoS ONE. 2014;9:e102817 pubmed publisher
    ..is positively correlated with tumorigenic CD151 expression, but is negatively correlated with tumor-suppressive CD63 expression in mouse fibrotic and human hepatic carcinoma tissues, indicating cooperative roles of the tetraspanins ..
  52. Tong X, Guo M, Jin M, Chen H, Li Y, Wei J. In silico epitope prediction, expression and functional analysis of Per a 10 allergen from the American cockroach. Int J Mol Med. 2016;38:1806-1814 pubmed publisher
    ..Our results also revealed that the expression of CD63 and CCR3 on passively sensitized basophils (obtained sera of patients with American CR allergies) was increased by ..
  53. Hammond C, Denzin L, Pan M, Griffith J, Geuze H, Cresswell P. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. J Immunol. 1998;161:3282-91 pubmed
    ..Similar experiments showed CD63, another tetraspan protein found in MIICs, also associates with these molecules in the compartment and that CD82 ..
  54. Wauters A, Esmaeilzadeh F, Bladt S, Beukinga I, Wijns W, van de Borne P, et al. Pro-thrombotic effect of exercise in a polluted environment: a P-selectin- and CD63-related platelet activation effect. Thromb Haemost. 2015;113:118-24 pubmed publisher
    ..Platelet activation was evaluated by surface expression of CD62P (P-selectin) and CD63 (dense granule glycoprotein) using flow cytometry of labelled platelets...
  55. Zhang Y, Guan D, Xia C, Han Z, Xu J, Gao J, et al. Relationship between the expression levels of CD61, CD63, and PAC-1 on platelet surface in peripheral blood and the transplanted kidney function. Transplant Proc. 2003;35:1360-3 pubmed
    To analyze the relationships between the expression levels of CD61, CD63, and PAC-1 on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation...
  56. Harrison Lavoie K, Michaux G, Hewlett L, Kaur J, Hannah M, Lui Roberts W, et al. P-selectin and CD63 use different mechanisms for delivery to Weibel-Palade bodies. Traffic. 2006;7:647-62 pubmed
    ..and AP-3 has previously been shown to play a role in the trafficking of both WPB membrane proteins, P-selectin and CD63. However, WPB are thought to form at the trans Golgi network (TGN), which is inconsistent with a role for AP-3, ..
  57. Bilawchuk L, Griffiths C, Jensen L, Elawar F, Marchant D. The Susceptibilities of Respiratory Syncytial Virus to Nucleolin Receptor Blocking and Antibody Neutralization are Dependent upon the Method of Virus Purification. Viruses. 2017;9: pubmed publisher
    ..Western blot and mass spectrometry for the exosome markers superoxide dismutase [Cu-Zn] (SOD1) and the tetraspanin CD63. Although the purified virus stocks were equally susceptible to nucleolin-receptor blocking by the DNA aptamer ..
  58. Koh Y, Almughlliq F, Vaswani K, Peiris H, Mitchell M. Exosome enrichment by ultracentrifugation and size exclusion chromatography. Front Biosci (Landmark Ed). 2018;23:865-874 pubmed
    ..Method II) provided the best yield by nanoparticle tracking analyses (NTA), the presence of the exosomal markers CD63, Flotillin-1 and TSG-101 (immunoblotting) and showed exosome morphology using transmission electron microscopy (TEM)..
  59. Jouvenet N, Bieniasz P, Simon S. Imaging the biogenesis of individual HIV-1 virions in live cells. Nature. 2008;454:236-40 pubmed publisher
    ..These approaches allow a previously unobserved view of the genesis of individual virions and the determination of parameters of viral assembly that are inaccessible with conventional techniques. ..
  60. Blom T, Li S, Dichlberger A, Bäck N, Kim Y, Loizides Mangold U, et al. LAPTM4B facilitates late endosomal ceramide export to control cell death pathways. Nat Chem Biol. 2015;11:799-806 pubmed publisher
    ..By compartmentalizing ceramide, LAPTM4B controls key sphingolipid-mediated cell death mechanisms and emerges as a candidate for sphingolipid-targeting cancer therapies. ..
  61. Akiyama H, Ramirez N, Gudheti M, Gummuluru S. CD169-mediated trafficking of HIV to plasma membrane invaginations in dendritic cells attenuates efficacy of anti-gp120 broadly neutralizing antibodies. PLoS Pathog. 2015;11:e1004751 pubmed publisher
    ..Our study suggests that HIV-1 capture by CD169 can provide virus evasion from both innate (phagocytosis) and adaptive immune responses. ..
  62. Chandrasekaran P, Moore V, Buckley M, Spurrier J, Kehrl J, Venkatesan S. HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism. PLoS ONE. 2014;9:e86998 pubmed publisher
    ..Nef also profoundly downregulated the naturally truncated CXCR4 associated with WHIM syndrome and engineered variants of CXCR4 that resist CXCL12 induced internalization via an ubiquitinylation independent mechanism. ..
  63. Hogue I, Llewellyn G, Ono A. Dynamic Association between HIV-1 Gag and Membrane Domains. Mol Biol Int. 2012;2012:979765 pubmed publisher
    ..Relationships between Gag multimerization and microdomain association will be further discussed in the context of Gag localization to T-cell uropods and virological synapses. ..
  64. Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, et al. Characterization of three abundant mRNAs from human ovarian granulosa cells. DNA Cell Biol. 1990;9:479-85 pubmed
    ..revealed that pHGR122 was specific for a collagenase inhibitor and pHGR11 for melanoma-associated antigen ME491. Relative quantification by Northern analysis indicated that collagenase inhibitor mRNA is a major species in ..
  65. Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, et al. Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. J Hepatol. 2002;37:322-30 pubmed
    ..We evaluated the expression and function of four TM4SF, namely CD9, CD81, CD63 and CD151, and their involvement in HSC migration, adhesion, and proliferation...
  66. Lin D, Kamsteeg E, Zhang Y, Jin Y, Sterling H, Yue P, et al. Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels. J Biol Chem. 2008;283:7674-81 pubmed publisher
    In the present study, we tested the role of CD63 in regulating ROMK1 channels by protein-tyrosine kinase (PTK)...
  67. Hotta H, Miyamoto H, Hara I, Takahashi N, Homma M. Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences. Biochem Biophys Res Commun. 1992;185:436-42 pubmed
    Genomic structure of the ME491/CD63 antigen gene and promoter activity of the 5'-flanking regulatory sequences were studied. The antigen gene consists of eight exons that span 4 kilobase-pairs...
  68. Rani A, O Shea A, Ianov L, Cohen R, Woods A, Foster T. miRNA in Circulating Microvesicles as Biomarkers for Age-Related Cognitive Decline. Front Aging Neurosci. 2017;9:323 pubmed publisher
    ..microvesicles were isolated from the plasma and samples were found to be positive for the exosome marker CD63, with an enrichment of particles within the size range for exosomes...
  69. Rato S, Rausell A, Munoz M, Telenti A, Ciuffi A. Single-cell analysis identifies cellular markers of the HIV permissive cell. PLoS Pathog. 2017;13:e1006678 pubmed publisher
    ..The combination of CD25 high expression with other candidate biomarkers led to the identification of CD298, CD63 and CD317 as the best biomarkers for permissiveness...