CD62L

Summary

Gene Symbol: CD62L
Description: selectin L
Alias: CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1, L-selectin, CD62 antigen-like family member L, gp90-MEL, leukocyte surface antigen Leu-8, leukocyte-endothelial cell adhesion molecule 1, lymph node homing receptor, lymphocyte adhesion molecule 1, pln homing receptor
Species: human
Products:     CD62L

Top Publications

  1. Ivetic A, Deka J, Ridley A, Ager A. The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not Ezrin. J Biol Chem. 2002;277:2321-9 pubmed
  2. Kilian K, Dernedde J, Mueller E, Bahr I, Tauber R. The interaction of protein kinase C isozymes alpha, iota, and theta with the cytoplasmic domain of L-selectin is modulated by phosphorylation of the receptor. J Biol Chem. 2004;279:34472-80 pubmed
    ..The phosphorylation-regulated association of PKC isozymes with the cytoplasmic domain of L-selectin indicates an important role of this kinase family in L-selectin signal transduction. ..
  3. Ivetic A, Ridley A. The telling tail of L-selectin. Biochem Soc Trans. 2004;32:1118-21 pubmed
    ..This review describes currently known binding partners of the L-selectin tail and how their associations affect L-selectin function. ..
  4. Marschner S, Freiberg B, Kupfer A, Hunig T, Finkel T. Ligation of the CD4 receptor induces activation-independent down-regulation of L-selectin. Proc Natl Acad Sci U S A. 1999;96:9763-8 pubmed
  5. Dwir O, Steeber D, Schwarz U, Camphausen R, Kansas G, Tedder T, et al. L-selectin dimerization enhances tether formation to properly spaced ligand. J Biol Chem. 2002;277:21130-9 pubmed
    ..This is the first indication that shear stress augments effective selectin ligand density at local contact sites by promoting L-selectin encounter of immobilized ligand. ..
  6. Ivetic A, Florey O, Deka J, Haskard D, Ager A, Ridley A. Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering. J Biol Chem. 2004;279:33263-72 pubmed
    ..These results suggest that ERM proteins are required for microvillar positioning of L-selectin and that this is important both for leukocyte tethering and L-selectin shedding. ..
  7. Killock D, Parsons M, Zarrouk M, Ameer Beg S, Ridley A, Haskard D, et al. In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin. J Biol Chem. 2009;284:8833-45 pubmed publisher
    ..These results highlight a novel intracellular event that occurs as a consequence of L-selectin clustering, which could participate in transducing signals that promote the transition from rolling to arrest. ..
  8. Mommsen P, Barkhausen T, Hildebrand F, Zeckey C, Krettek C, van Griensven M. Regulation of L-selectin expression by trauma-relevant cytokines. Pathol Res Pract. 2011;207:142-7 pubmed publisher
    ..Therefore, a regulation of neutrophil activation on this level might be crucial in the development of posttraumatic complications. ..
  9. Srinivasan S, Deng W, Li R. L-selectin transmembrane and cytoplasmic domains are monomeric in membranes. Biochim Biophys Acta. 2011;1808:1709-15 pubmed publisher
    ..This study will provide constraints for future investigations on the interaction of L-selectin and its associating proteins. ..

More Information

Publications115 found, 100 shown here

  1. Wei Y, Lan Y, Meng L, Nong L. The association of L-selectin polymorphisms with L-selectin serum levels and risk of ischemic stroke. J Thromb Thrombolysis. 2011;32:110-5 pubmed publisher
    ..05). The P213S polymorphism of L-selectin and its sL-selectin levels are associated with ischemic stroke in Chinese population. Our data suggests that L-selectin gene may play a role in the development of ischemic stroke. ..
  2. Wedepohl S, Beceren Braun F, Riese S, Buscher K, Enders S, Bernhard G, et al. L-selectin--a dynamic regulator of leukocyte migration. Eur J Cell Biol. 2012;91:257-64 pubmed publisher
  3. Tomaschitz A, Pilz S, Ritz E, Grammer T, Amrein K, Merger S, et al. Relationship between plasma aldosterone concentration and soluble cellular adhesion molecules in patients referred to coronary angiography. Exp Clin Endocrinol Diabetes. 2011;119:649-55 pubmed publisher
  4. Lasky L, Singer M, Dowbenko D, Imai Y, Henzel W, Grimley C, et al. An endothelial ligand for L-selectin is a novel mucin-like molecule. Cell. 1992;69:927-38 pubmed
    ..These results thus define a tissue-specific mucin-like endothelial glycoprotein that appears to function as a scaffold that presents carbohydrates to the L-selectin lectin domain. ..
  5. Brenner B, Gulbins E, Schlottmann K, Koppenhoefer U, Busch G, Walzog B, et al. L-selectin activates the Ras pathway via the tyrosine kinase p56lck. Proc Natl Acad Sci U S A. 1996;93:15376-81 pubmed
    ..Our results point to a signaling cascade from L-selectin via p56lck, Grb2/Sos, Ras, and Rac2 to 2-O...
  6. Dwir O, Kansas G, Alon R. An activated L-selectin mutant with conserved equilibrium binding properties but enhanced ligand recognition under shear flow. J Biol Chem. 2000;275:18682-91 pubmed
  7. Matala E, Alexander S, Kishimoto T, Walcheck B. The cytoplasmic domain of L-selectin participates in regulating L-selectin endoproteolysis. J Immunol. 2001;167:1617-23 pubmed
    ..L-selectin (CD62L) is a leukocyte expressed adhesion protein that is important for neutrophil accumulation and rolling along the ..
  8. Ding Z, Issekutz T, Downey G, Waddell T. L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration. Blood. 2003;101:4245-52 pubmed
    ..Taken together, L-selectin-mediated signals specifically enhance CXCR4 expression and function, suggesting a novel mechanism for the modulation of lymphocyte activation during cell adhesion and transmigration. ..
  9. Wang J, Marschner S, Finkel T. CXCR4 engagement is required for HIV-1-induced L-selectin shedding. Blood. 2004;103:1218-21 pubmed
    ..demonstrated that ligation of CD4 by T-cell tropic HIV-1 NL4-3 induces metalloproteinase-dependent L-selectin (CD62L) shedding on resting CD4(+) T cells. However, the role of CXCR4 in HIV-induced L-selectin shedding is unclear...
  10. Fabre S, Carrette F, Chen J, Lang V, Semichon M, Denoyelle C, et al. FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase. J Immunol. 2008;181:2980-9 pubmed
    ..Together, these results reveal a new function of FOXO1 in the immune system and suggest that PI3K controls a coordinated network of transcription factors regulating both cell quiescence and homing of human T lymphocytes. ..
  11. Deng W, Srinivasan S, Zheng X, Putkey J, Li R. Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding. J Mol Biol. 2011;411:220-33 pubmed publisher
    ..These results suggest that the association of CaM with L-selectin in the cell can be influenced by the membrane bilayer and that anionic lipids may modulate ectodomain shedding of transmembrane receptors. ..
  12. Dunne J, van Eeden S, Keen K. L-selectin and skin damage in systemic sclerosis. PLoS ONE. 2012;7:e44814 pubmed publisher
    ..Modulation of circulating L-selectin is a promising target for reducing skin damage in dSSc patients. Plasma levels of soluble L-selectin could serve as an outcome measure for dSSc patients in clinical trials. ..
  13. Ogunade I, Arriola K, Jiang Y, Driver J, Staples C, Adesogan A. Effects of 3 sequestering agents on milk aflatoxin M1 concentration and the performance and immune status of dairy cows fed diets artificially contaminated with aflatoxin B1. J Dairy Sci. 2016;99:6263-6273 pubmed publisher
    ..The mean fluorescence intensity of antibody staining for 2 leukocyte adhesion molecules, L-selectin (CD62L) and ?-integrin (CD18), tended to be greatest when SEQ1 and SEQ3 were fed...
  14. Nace E, Nickerson S, Kautz F, Breidling S, Wochele D, Ely L, et al. Modulation of innate immune function and phenotype in bred dairy heifers during the periparturient period induced by feeding an immunostimulant for 60 days prior to delivery. Vet Immunol Immunopathol. 2014;161:240-50 pubmed publisher
    ..The fraction of leukocytes with measurable CD62L (L-selectin) on their surface from supplemented heifers tended to be greater during the periparturient period in ..
  15. Kolachala V, Palle S, Shen M, Feng A, Shayakhmetov D, Gupta N. Loss of L-selectin-guided CD8+ , but not CD4+ , cells protects against ischemia reperfusion injury in a steatotic liver. Hepatology. 2017;66:1258-1274 pubmed publisher
    ..Hepatic lymphocytes demonstrated increased CD8+ /CD62L+ (L-selectin) cells in HFD-fed mice after IRI...
  16. Menegat L, Simas R, Caliman J, Zanoni F, Jacysyn J, da Silva L, et al. Evidence of bone marrow downregulation in brain-dead rats. Int J Exp Pathol. 2017;98:158-165 pubmed publisher
    ..9; CD11b/c, P = 0.7; CD62L, P = 0.1). There were no differences in the percentage of apoptosis and necrosis (Annexin V, P = 0...
  17. Zuchtriegel G, Uhl B, Hessenauer M, Kurz A, Rehberg M, Lauber K, et al. Spatiotemporal expression dynamics of selectins govern the sequential extravasation of neutrophils and monocytes in the acute inflammatory response. Arterioscler Thromb Vasc Biol. 2015;35:899-910 pubmed publisher
    ..Whereas constitutively expressed leukocyte L-selectin/CD62L and endothelial P-selectin/CD62P together with CD44 and P-selectin glycoprotein ligand-1/CD162 initiate the ..
  18. Riese S, Kuehne C, Tedder T, Hallmann R, Hohenester E, Buscher K. Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling. J Immunol. 2014;192:1862-9 pubmed publisher
    ..In this study, we show that the anti-human L-selectin mAbs DREG-55 and LAM1-5 but not DREG-56, DREG-200, or LAM1-1 heterotropically modulate adhesion presumably by stabilizing the extended ..
  19. Blagitz M, Souza F, Batista C, Diniz S, Azevedo L, Silva M, et al. Flow cytometric analysis: Interdependence of healthy and infected udder quarters. J Dairy Sci. 2015;98:2401-8 pubmed publisher
    ..cytometry, we evaluated the percentage of milk neutrophils and their expression of adhesion molecules L-selectin (CD62L), β2-integrin (CD11b), and an endothelial-selectin ligand (CD44); levels of intracellular reactive oxygen ..
  20. Kuret T, Lakota K, Zigon P, Ogrič M, Sodin Semrl S, Cucnik S, et al. Insight into inflammatory cell and cytokine profiles in adult IgA vasculitis. Clin Rheumatol. 2019;38:331-338 pubmed publisher
    ..There was a 16% elevation in neutrophils in IgAV patients, with IgAV neutrophils showing significantly higher CD62L surface expression...
  21. Saifodine A, Fyfe J, Sievers A, Coelho E, Azam K, Black J. Genetic diversity of Mycobacterium tuberculosis isolates obtained from patients with pulmonary tuberculosis in Beira city, Mozambique. Int J Mycobacteriol. 2014;3:94-100 pubmed publisher
    ..The TB epidemic in Beira city is caused by a diverse group of MTB strains predominantly belonging to lineages 1 and 4. ..
  22. Kiss A, Filipek A, Żyżyńska Granica B, Naruszewicz M. Effects of penta-O-galloyl-β-D-glucose on human neutrophil function: significant down-regulation of L-selectin expression. Phytother Res. 2013;27:986-92 pubmed publisher
    ..generation (ROS), metalloproteinase-9 and interleukin-8 secretion (IL-8), β₂ integrin (CD11b) and L-selectin (CD62L) expression and apoptosis...
  23. Fung E, Esposito L, Todd J, Wicker L. Multiplexed immunophenotyping of human antigen-presenting cells in whole blood by polychromatic flow cytometry. Nat Protoc. 2010;5:357-70 pubmed publisher
    ..g., CX(3)CR1 and CCR2), adhesion (e.g., CD11b and CD62L), antigen presentation (e.g., CD83, CD86 and CD209) and immune regulation (e.g., CD101) on circulating APCs...
  24. Nguyen V, Bañuls A, Tran T, Pham K, Nguyen T, Nguyen H, et al. Mycobacterium tuberculosis lineages and anti-tuberculosis drug resistance in reference hospitals across Viet Nam. BMC Microbiol. 2016;16:167 pubmed publisher
    ..Male patients of working ages should be the focus for better control to prevent the emergence of drug-resistant TB. ..
  25. da Costa Martins P, van den Berk N, Ulfman L, Koenderman L, Hordijk P, Zwaginga J. Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation. Arterioscler Thromb Vasc Biol. 2004;24:193-9 pubmed
    ..These interactions are mainly mediated by P-selectin and PSGL-1. PMCs in the circulation might be proatherogenic, and prevention of their formation is a possible therapeutic goal. ..
  26. Golubovskaya V, Wu L. Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy. Cancers (Basel). 2016;8: pubmed publisher
    ..and Tfh) and CD8? memory and effector subsets differ in extra-cellular (CD25, CD45RO, CD45RA, CCR-7, L-Selectin [CD62L], etc...
  27. Sava F, Toldi G, Treszl A, Hajdu J, Harmath A, Tulassay T, et al. Expression of lymphocyte activation markers of preterm neonates is associated with perinatal complications. BMC Immunol. 2016;17:19 pubmed publisher
    ..as prenatal steroid treatment (PS) and the frequency of activated T lymphocyte subsets (HLA-DR+, CD69+, CD25+, CD62L+) and major T lymphocyte subpopulations (CD4, CD8, Th1, Th2, naïve, memory) in peripheral blood during the first ..
  28. Zhao W, Xu S, Liang J, Peng L, Liu H, Wang Z, et al. Endothelial progenitor cells from human fetal aorta cure diabetic foot in a rat model. Metabolism. 2016;65:1755-1767 pubmed publisher
    ..These findings suggest that the transplantation of HFA-derived EPCs could serve as an innovative therapeutic strategy for managing DF. ..
  29. Horstkorte R, Rau K, Reutter W, Nöhring S, Lucka L. Increased expression of the selectin ligand sialyl-Lewis(x) by biochemical engineering of sialic acids. Exp Cell Res. 2004;295:549-54 pubmed
    ..Surprisingly, incorporation of N-propanoyl neuraminic acid into glycoconjugates of these cells leads to a dramatic increase of sialyl-Lewis(x) structures and to increased adhesion to selectins. ..
  30. Flores Santibáñez F, Fernández D, Meza D, Tejón G, Vargas L, Varela Nallar L, et al. CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells. Immunology. 2015;146:582-94 pubmed publisher
    ..Within the tumour microenvironment, CD73 is highly expressed in CD62L(+) CD127(+) CD8(+) T cells (memory T cells) and is down-regulated in GZMB(+) KLRG1(+) CD8(+) T cells (terminally ..
  31. Kashihara H, Nakayama T, Hatta T, Takahashi N, Fujita M. Evaluating the Quality of Website Information of Private-Practice Clinics Offering Cell Therapies in Japan. Interact J Med Res. 2016;5:e15 pubmed publisher
    ..It is important that more similar studies are undertaken globally to enable an orchestrated regulatory approach toward private-practice clinics. ..
  32. Halling C, Seidemann R. They Sell Skulls Online?! A Review of Internet Sales of Human Skulls on eBay and the Laws in Place to Restrict Sales. J Forensic Sci. 2016;61:1322-6 pubmed publisher
    ..Ultimately, the goal is to stem the commodification of such items and to recover skeletal material, especially that which may be of archaeological or forensic significance, and provide the proper final disposition for such material. ..
  33. Aldridge J, Askew R. Delivery dilemmas: How drug cryptomarket users identify and seek to reduce their risk of detection by law enforcement. Int J Drug Policy. 2017;41:101-109 pubmed publisher
    ..The abundance of drug market intelligence available to those on both sides of the law may function to speed up innovation in illegal drug markets, as well as necessitate and facilitate the development of law enforcement responses. ..
  34. Stergiou Kita M, Grigorovich A, Damianakis T, Le Dorze G, David C, Lemsky C, et al. The big sell: Managing stigma and workplace discrimination following moderate to severe brain injury. Work. 2017;57:245-258 pubmed publisher
    ..Public understanding about PWBI remains limited. PWBI require further assistance to manage disclosure and incidents of workplace discrimination. ..
  35. Hanley W, Napier S, Burdick M, Schnaar R, Sackstein R, Konstantopoulos K. Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells. FASEB J. 2006;20:337-9 pubmed
    ..The novel finding that CD44v are selectin ligands offers a unifying perspective on the apparent enhanced metastatic potential associated with tumor cell CD44v overexpression and the critical role of selectins in metastasis. ..
  36. Landers J, Melki J, Meininger V, Glass J, van den Berg L, van Es M, et al. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2009;106:9004-9 pubmed publisher
    ..These findings support the view that genetic factors modify phenotypes in this disease and that cellular motor proteins are determinants of motor neuron viability. ..
  37. Hertwig L, Pache F, Romero Suarez S, Stürner K, Borisow N, Behrens J, et al. Distinct functionality of neutrophils in multiple sclerosis and neuromyelitis optica. Mult Scler. 2016;22:160-73 pubmed publisher
    ..and MS, including evaluation of neutrophil immune response (fMLP receptor, TLR2), chemotaxis and migration (CXCR1, CD62L, CD43), regulation of complement (CD46, CD55, CD59), respiratory burst, phagocytosis and degranulation...
  38. Sheridan H, Reichle E, Reingold E. Why does removing inter-word spaces produce reading deficits? The role of parafoveal processing. Psychon Bull Rev. 2016;23:1543-1552 pubmed
    ..We discuss the implications of our results for models of eye-movement control. ..
  39. Tzvetkova M, Pardal M, Disley E, Rena A, Talic S, Forberger S. Strategies for a risky business: How drug dealers manage customers, suppliers and competitors in Italy, Slovenia and Germany. Int J Drug Policy. 2016;31:90-8 pubmed publisher
    ..The research highlights some differences, but important similarities between dealers who were part of organised crime groups and those who were not; dealers all faced some common challenges and adopted some common responses to these. ..
  40. Crookenden M, Heiser A, Murray A, Dukkipati V, Kay J, Loor J, et al. Parturition in dairy cows temporarily alters the expression of genes in circulating neutrophils. J Dairy Sci. 2016;99:6470-6483 pubmed publisher
    ..This altered function may predispose cows to disease over the transition period and is likely to be a natural change in function due to parturition. ..
  41. Argento E, Taylor M, Jollimore J, Taylor C, Jennex J, Krusi A, et al. The Loss of Boystown and Transition to Online Sex Work: Strategies and Barriers to Increase Safety Among Men Sex Workers and Clients of Men. Am J Mens Health. 2016;: pubmed
  42. Goncalves R, Rodrigues V, Vasconcelos H. Reference pricing in the presence of pseudo-generics. Int J Health Econ Manag. 2015;15:281-305 pubmed
    ..Our results have important policy implications such as showing that the presence of pseudo-generics reinforces reference pricing's advantages over alternative reimbursement schemes. ..
  43. Zinsou C, Cherifath A. The malaria testing and treatment landscape in Benin. Malar J. 2017;16:174 pubmed publisher
    ..These findings highlight the need for increased engagement with the private sector to improve malaria case management and an immediate need for a national ACT subsidy. ..
  44. Gorosito Serrán M, Tosello Boari J, Fiocca Vernengo F, Beccaria C, Ramello M, Bermejo D, et al. Unconventional Pro-inflammatory CD4+ T Cell Response in B Cell-Deficient Mice Infected with Trypanosoma cruzi. Front Immunol. 2017;8:1548 pubmed publisher
    ..CD4+ T cells from infected muMT mice presented a high frequency of CD62LhiCD44- cells, which is commonly associated with a naïve phenotype...
  45. Chen S, Dallas M, Balzer E, Konstantopoulos K. Mucin 16 is a functional selectin ligand on pancreatic cancer cells. FASEB J. 2012;26:1349-59 pubmed publisher
    ..These findings provide a novel integrated perspective on the enhanced metastatic potential associated with MUC16 overexpression and the role of selectins in metastasis. ..
  46. Nguyen V, Choisy M, Nguyen D, Tran T, Pham K, Thi Dinh P, et al. High prevalence of Beijing and EAI4-VNM genotypes among M. tuberculosis isolates in northern Vietnam: sampling effect, rural and urban disparities. PLoS ONE. 2012;7:e45553 pubmed publisher
  47. Boix Giner F, Millán O, San Segundo D, Muñoz Cacho P, Mancebo E, Llorente S, et al. High frequency of central memory regulatory T cells allows detection of liver recipients at risk of early acute rejection within the first month after transplantation. Int Immunol. 2016;28:55-64 pubmed publisher
    ..The percentage of central memory (cm) Treg cells (CD4(+)CD25(high)CD45RO(+)CD62L(+)) was monitored at pre-transplant and at 1 and 2 weeks, and 1, 2, 3 and 6 months and 1 year post-transplantation...
  48. Smith C. Scouting For Approval: Lessons on Medical Device Regulation in an Era of Crowdfunding from Scanadu's "Scout". Food Drug Law J. 2015;70:209-35, iii pubmed
    ..This guidance should ensure the continued commitment to consumer safety that is at the core of FDA regulation. ..
  49. Sauce D, Dong Y, Campillo Gimenez L, Casulli S, Bayard C, Autran B, et al. Reduced Oxidative Burst by Primed Neutrophils in the Elderly Individuals Is Associated With Increased Levels of the CD16bright/CD62Ldim Immunosuppressive Subset. J Gerontol A Biol Sci Med Sci. 2017;72:163-172 pubmed publisher
    ..of proinflammatory cytokines, resting PMNs from the elderly individuals were not activated as shown by normal CD62L and CD11b expression at the PMN surface and normal constitutive reactive oxygen species (ROS) production...
  50. Engholm V, Boria D. Proposing a Health Humanities Minor: Some Lessons. J Med Humanit. 2017;38:409-417 pubmed publisher
    ..We conclude with some final reflections on the current status of our program and why we are committed to health humanities education. ..
  51. Wagenaar A, Livingston M, Pettigrew D, Kominsky T, Komro K. Communities Mobilizing for Change on Alcohol (CMCA): Secondary Analyses of an RCT Showing Effects of Community Organizing on Alcohol Acquisition by Youth in the Cherokee Nation. Addiction. 2017;: pubmed publisher
  52. Cheng Y, Li H, Deng Y, Tai Y, Zeng K, Zhang Y, et al. Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma. Cell Death Dis. 2018;9:422 pubmed publisher
    ..from HCC-CAFs with increased expression of CD66b, PDL1, IL8, TNFa, and CCL2, and with decreased expression of CD62L. HCC-CAF-primed neutrophils impaired T-cell function through the PD1/PDL1 signaling pathway...
  53. Siegelman M, Weissman I. Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. Proc Natl Acad Sci U S A. 1989;86:5562-6 pubmed
    A cDNA clone homologous to the mouse lymph node homing receptor core protein (mLHRc) was isolated from a cDNA library derived from stimulated human peripheral blood lymphocytes...
  54. Jones S, Trocha S, Strange M, Granger D, Kevil C, Bullard D, et al. Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury. Am J Physiol Heart Circ Physiol. 2000;279:H2196-201 pubmed
    ..We conclude that P-selectin, E-selectin, ICAM-1, and CD18 are involved in the pathogenesis of MI/R injury in mice...
  55. Hajilooi M, Tajik N, Sanati A, Eftekhari H, Massoud A. Association of the Phe206Leu allele of the L-selectin gene with coronary artery disease. Cardiology. 2006;105:113-8 pubmed
    ..Our findings suggest that carriage of L-selectin 206Leu mutant allele could contribute to susceptibility of Iranian individuals to contracting coronary artery disease. ..
  56. Watanabe T, Suzuki J, Mitsuo A, Nakano S, Tamayama Y, Katagiri A, et al. Striking alteration of some populations of T/B cells in systemic lupus erythematosus: relationship to expression of CD62L or some chemokine receptors. Lupus. 2008;17:26-33 pubmed
    ..In the present study, changes in these populations of CD4+ T cells were examined on the basis of the expression of CD62L, CCR7 and CXCR5 in patients with systemic lupus erythematosus (SLE) in relation to CCL21 and CXCL10...
  57. Chen C, Shang X, Cui L, Xu T, Luo J, Ba X, et al. L-selectin ligation-induced CSF-1 gene transcription is regulated by AP-1 in a c-Abl kinase-dependent manner. Hum Immunol. 2008;69:501-9 pubmed publisher
    ..These results indicate that nuclear c-Abl kinase can activate CSF-1 gene transcription by regulating AP-1 activity in the signaling events induced by L-selectin ligation. ..
  58. Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, et al. Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study. PLoS ONE. 2014;9:e88150 pubmed publisher
    ..Further longitudinal studies of larger populations are needed to confirm these findings. ..
  59. Yi H, Miller G, Zhang L, Li S, Rozelle S. Intended and unintended consequences of China's zero markup drug policy. Health Aff (Millwood). 2015;34:1391-8 pubmed publisher
    ..Thus, the reform had an important unintended consequence: China's health care providers have sought new, potentially inappropriate, forms of revenue. ..
  60. Coelho Dos Reis J, Huang J, Tsao T, Pereira F, Funakoshi R, Nakajima H, et al. Co-administration of ?-GalCer analog and TLR4 agonist induces robust CD8(+) T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells. Clin Immunol. 2016;168:6-15 pubmed publisher
    ..e. CD44(+)CD62L(-)NKT cells...
  61. Francis A, Bosio E, Stone S, Fatovich D, Arendts G, Nagree Y, et al. Neutrophil activation during acute human anaphylaxis: analysis of MPO and sCD62L. Clin Exp Allergy. 2017;47:361-370 pubmed publisher
    ..Plasma myeloperoxidase concentrations were measured by ELISA, serum soluble CD62L concentrations by cytometric bead array, and both compared to healthy controls...
  62. Beverley P. Human T cell subsets. Immunol Lett. 1987;14:263-7 pubmed
    ..Several antigens not related to CD45, such as 4B4, Leu8, TQ1 and 9.3, identify functionally distinct subsets rather than stages of T cell maturation.
  63. Chen C, Cui L, Shang X, Zeng X. NFAT regulates CSF-1 gene transcription triggered by L-selectin crosslinking. Biocell. 2010;34:57-63 pubmed
    ..These results indicate that nuclear NFAT can activate CSF-1 gene transcription by connecting with the CSF-1 promoter in the signaling events induced by L-selectin ligation. ..
  64. Camps Bossacoma M, Abril Gil M, Saldaña Ruíz S, Franch A, Perez Cano F, Castell M. Cocoa Diet Prevents Antibody Synthesis and Modifies Lymph Node Composition and Functionality in a Rat Oral Sensitization Model. Nutrients. 2016;8:242 pubmed publisher
    ..In addition, this diet increased the proportion of TCR??+ and CD103+CD8+ cells and decreased the proportion of CD62L+CD4+ and CD62L+CD8+ cells in MLN, whereas it upregulated the gene expression of OX40L, CD11c, and IL-1? and ..
  65. Schilderink R, Bell M, Reginato E, Patten C, Rioja I, Hilbers F, et al. BET bromodomain inhibition reduces maturation and enhances tolerogenic properties of human and mouse dendritic cells. Mol Immunol. 2016;79:66-76 pubmed publisher
    ..while I-BET151 treatment of BMDC did not affect their ability to polarise ovalbumin specific CD4+ CD62L+ naive T cells towards Th1, Th2, or Th17 phenotypes, an increase in Foxp3 expressing Tregs secreting ..
  66. Kadono T, Venturi G, Steeber D, Tedder T. Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. J Immunol. 2002;169:4542-50 pubmed
    ..Thus, in addition to mediating leukocyte firm adhesion, CD18 integrin/ICAM-1 interactions regulate leukocyte rolling velocities and thereby optimize L-selectin-mediated leukocyte rolling. ..
  67. Watanabe Y, Inoue T, Okada H, Kotaki S, Kanno Y, Kikuta T, et al. Impact of selectin gene polymorphisms on rapid progression to end-stage renal disease in patients with IgA nephropathy. Intern Med. 2006;45:947-51 pubmed
    ..This study provides a possible association between the selectin gene polymorphisms and the rapid progression to ESRD in IgAN patients. ..
  68. Lowenstein D, Gharehaghaji M, Wise D. Substantial Mortality of Cabbage Looper (Lepidoptera: Noctuidae) From Predators in Urban Agriculture Is not Influenced by Scale of Production or Variation in Local and Landscape-Level Factors. Environ Entomol. 2017;46:30-37 pubmed publisher
    ..Our results suggest that urban growers benefit from high consumption rates of cabbage looper eggs and larvae by arthropod predators. ..
  69. Korz C, Pscherer A, Benner A, Mertens D, Schaffner C, Leupolt E, et al. Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes. Blood. 2002;99:4554-61 pubmed
    ..In contrast, in MCL the impairment of apoptosis induction seems to play a minor role, whereas most expression data indicate an enhancement of cell proliferation. ..
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    ..No association was found between the severity of CHD and the Lselectin gene P213S polymorphism Our findings suggest that L-selectin gene 213P mutant allele might contribute to susceptibility of Chinese individuals to contract CHD. ..
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    ..in peripheral blood circulation and that the amount of lymphocyte redistribution in NK cells was dependent on the CD62L expression density. Specifically, CD62L- cells were mobilized more pronouncedly than were CD62L+ cells...
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    ..These results demonstrate that TyrSO(3) residues in association with a C2-SLe(x) moiety within endoglycan and PSGL-1 are preferentially recognized by L-selectin. ..
  78. Mehta D souza P, Klopocki A, Oganesyan V, Terzyan S, Mather T, Li Z, et al. Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J Biol Chem. 2017;292:2510-2518 pubmed publisher
    ..Cells expressing E-selectinE88D rolled but detached faster. Our data support a two-state model for selectins in which Glu-88 must engage ligand to trigger allostery that stabilizes the high affinity state under force. ..
  79. Lefrançois P, Tetzlaff M, Moreau L, Watters A, Netchiporouk E, Provost N, et al. TruSeq-Based Gene Expression Analysis of Formalin-Fixed Paraffin-Embedded (FFPE) Cutaneous T-Cell Lymphoma Samples: Subgroup Analysis Results and Elucidation of Biases from FFPE Sample Processing on the TruSeq Platform. Front Med (Lausanne). 2017;4:153 pubmed publisher
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    ..Additionally, TWS119 can induce the expression of CD62L or CCR5 to generate a population of CD62L+??T or CCR5+??T cells in a dose-dependent manner...
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    ..in vitro CD3/CD28 or PMA/Iono stimulation 2) in vitro proliferation properties 3) CD8+ CD44+ CD62Llow and CD62Lhi T cells repartition 4) transcriptomic signature as revealed by RNA sequencing...
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    ..Thus, isolated CD4+CD62L+ T cells from CD6-deficient mice displayed decreased in vitro T-helper type 17 polarization...
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    ..g. HCELL). These data define a novel class of L-selectin ligands and expand the scope of function for L-selectin within circulatory systems to now include a novel activity within shear stresses characteristic of lymphatic flow. ..
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  86. Schwab N, Schneider Hohendorf T, Posevitz V, Breuer J, Göbel K, Windhagen S, et al. L-selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients. Neurology. 2013;81:865-71 pubmed publisher
    ..0001). Samples were gathered between 4 and 26 months before PML diagnosis. The cell-based assessment of the percentage of l-selectin-expressing CD4 T cells could provide an urgently needed biomarker for individual PML risk assessment. ..
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    ..We conclude that this is a signaling complex specialized for sensing adhesion under flow. ..
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    ..we demonstrated that antigen-induced expansion of primary NKTs in vitro associates with the accumulation of a CD62L+ subset and exhaustion of CD62L- cells...
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    ..Additionally, ssRNA40 promoted the expression of CD62L and TNF-? and the production of ROS in the presence of the TLR2 agonist Pam2CSK4...
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