CD6

Summary

Gene Symbol: CD6
Description: CD6 molecule
Alias: TP120, T-cell differentiation antigen CD6, CD6 antigen, T12
Species: human
Products:     CD6

Top Publications

  1. Kofler D, Severson C, Mousissian N, De Jager P, Hafler D. The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. J Immunol. 2011;187:3286-91 pubmed publisher
    ..8 × 10(-9)), that is found in a block of linkage disequilibrium containing the CD6 gene...
  2. Nair P, Melarkode R, Rajkumar D, Montero E. CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction. Clin Exp Immunol. 2010;162:116-30 pubmed publisher
    The CD6 membrane-proximal scavenger receptor cysteine-rich domain (SRCR3) includes the activated leucocyte cell adhesion molecule (ALCAM) binding site...
  3. Whitney G, Starling G, Bowen M, Modrell B, Siadak A, Aruffo A. The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site. J Biol Chem. 1995;270:18187-90 pubmed
    Binding studies with a CD6 immunoglobulin fusion protein (CD6 Rg) resulted in the identification and cloning of a CD6 ligand...
  4. Robinson W, Neuman de Vegvar H, Prohaska S, Rhee J, Parnes J. Human CD6 possesses a large, alternatively spliced cytoplasmic domain. Eur J Immunol. 1995;25:2765-9 pubmed
    Human CD6 is a monomeric 105/130-kDa T cell surface glycoprotein that is involved in T cell activation...
  5. De Jager P, Chibnik L, Cui J, Reischl J, Lehr S, Simon K, et al. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol. 2009;8:1111-9 pubmed publisher
    ..Future iterations of the wGRS might therefore make a contribution to algorithms that can predict a diagnosis of MS in a clinical or research setting. ..
  6. Sarrias M, Farnós M, Mota R, Sánchez Barbero F, Ibáñez A, Gimferrer I, et al. CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock. Proc Natl Acad Sci U S A. 2007;104:11724-9 pubmed
    b>CD6 is a lymphocyte receptor that belongs to the scavenger receptor cysteine-rich superfamily...
  7. Castro M, Oliveira M, Nunes R, Fabre S, Barbosa R, Peixoto A, et al. Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. J Immunol. 2007;178:4351-61 pubmed
    ..We have cloned and characterized a new isoform of the accessory molecule CD6 that lacks the CD166 binding domain and is expressed in rat and human primary cells...
  8. Ibáñez A, Sarrias M, Farnós M, Gimferrer I, Serra Pagès C, Vives J, et al. Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor. J Immunol. 2006;177:1152-9 pubmed
    b>CD6 is a cell surface receptor primarily expressed on immature thymocytes and mature T and B1a lymphocytes...
  9. Gimferrer I, Ibáñez A, Farnós M, Sarrias M, Fenutría R, Roselló S, et al. The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains. J Immunol. 2005;175:1406-14 pubmed
    b>CD6 is a type I membrane glycoprotein expressed on thymocytes, mature T and B1a lymphocytes, and CNS cells...

More Information

Publications87

  1. Aruffo A, Melnick M, Linsley P, Seed B. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. J Exp Med. 1991;174:949-52 pubmed
    The isolation, characterization, and expression of a full-length cDNA encoding the human T cell glycoprotein CD6 is described...
  2. Johnson B, Wang J, Taylor E, Caillier S, Herbert J, Khan O, et al. Multiple sclerosis susceptibility alleles in African Americans. Genes Immun. 2010;11:343-50 pubmed publisher
    ..b>CD6, CLEC16a, EVI5, GPC5, and TYK2 contained SNPs that are associated with MS risk in the African American data set...
  3. De Jager P, Jia X, Wang J, de Bakker P, Ottoboni L, Aggarwal N, et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet. 2009;41:776-82 pubmed publisher
    ..59 x 10(-11)), IRF8 (P = 3.73 x 10(-9)) and CD6 (P = 3.79 x 10(-9))...
  4. Hassan N, Simmonds S, Clarkson N, Hanrahan S, Puklavec M, Bomb M, et al. CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. Mol Cell Biol. 2006;26:6727-38 pubmed
    ..We show that expression of CD6 in T cells limits their responsiveness but that engagement by the physiological ligand CD166 gives costimulation...
  5. Zimmerman A, Joosten B, Torensma R, Parnes J, van Leeuwen F, Figdor C. Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. Blood. 2006;107:3212-20 pubmed
    ..Here, we show that CD6 and its ligand activated leukocyte cell adhesion molecule (ALCAM) are actively recruited to the antigen-induced ..
  6. Gimferrer I, Calvo M, Mittelbrunn M, Farnós M, Sarrias M, Enrich C, et al. Relevance of CD6-mediated interactions in T cell activation and proliferation. J Immunol. 2004;173:2262-70 pubmed
    b>CD6 is a cell surface receptor expressed on immature thymocytes and mature T and B1a lymphocytes...
  7. Gimferrer I, Farnós M, Calvo M, Mittelbrunn M, Enrich C, Sanchez Madrid F, et al. The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells. J Biol Chem. 2003;278:8564-71 pubmed
    CD5 and CD6 are closely related lymphocyte surface receptors of the scavenger receptor cysteine-rich superfamily, which show highly homologous extracellular regions but little conserved cytoplasmic tails...
  8. Bowen M, Whitney G, Neubauer M, Starling G, Palmer D, Zhang J, et al. Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms. J Immunol. 1997;158:1149-56 pubmed
    The CD6 protein has been shown to play important roles in T cell costimulation and adhesion. Recently, variably spliced isoforms of CD6 mRNA have been identified in both human and murine T cells...
  9. Wee S, Schieven G, Kirihara J, Tsu T, Ledbetter J, Aruffo A. Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors. J Exp Med. 1993;177:219-23 pubmed
    ..Here we show that Tyr residues in the cytoplasmic domain of CD6 become phosphorylated upon T cell activation via the TCR complex...
  10. Ahire J, Mokashe N, Chaudhari B. Effect of Dietary Probiotic Lactobacillus helveticus on Growth Performance, Antioxidant Levels, and Absorption of Essential Trace Elements in Goldfish (Carassius auratus). Probiotics Antimicrob Proteins. 2018;: pubmed publisher
    In this study, we have investigated the effect of probiotic Lactobacillus helveticus CD6 supplemented into simple laboratory fish feed (LFF) and complex, multi-ingredient market fish feed (MFF) on growth performance, antioxidant levels, ..
  11. Jurewicz A, Zaleski K, Domowicz M, Selmaj K. High CD6 and low chemokine receptor expression on peripheral blood lymphocytes correlates with MRI gadolinium enhancement in MS. J Neuroimmunol. 2014;276:187-94 pubmed publisher
    Correlation between gadolinium-enhancing [Gd(+)] lesions on MRI and expression of CD6 molecules and a group of chemokine receptors on peripheral blood (PB) and cerebrospinal fluid (CSF) immune cells was measured in multiple sclerosis (MS)..
  12. Kulakova O, Bashinskaya V, Kiselev I, Baulina N, Tsareva E, Nikolaev R, et al. Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis: the impact of genome-wide association studies identified disease risk loci. Pharmacogenomics. 2017;18:1563-1574 pubmed publisher
    ..032 - 0.00092). The biallelic combinations including EOMES, CLEC16A, IL22RA2, PVT1, TYK2, CD6, IL7RA and IRF8 genes were associated with response to GA with increased significance level (p f  = 0...
  13. Meunier L. [What's new in dermatological therapy?]. Ann Dermatol Venereol. 2014;141 Suppl 4:S643-53 pubmed publisher
    ..to the treatment of psoriasis (anti-TNF, ustekinumab, antibodies against IL-17 or its receptors, anti-IL-23, anti-CD6 and ponesimod)...
  14. Hernandez P, Moreno E, Aira L, Rodriguez P. Therapeutic Targeting of CD6 in Autoimmune Diseases: A Review of Cuban Clinical Studies with the Antibodies IOR-T1 and Itolizumab. Curr Drug Targets. 2016;17:666-77 pubmed
    The CD6 molecule is a pan T cell marker involved in T cell regulation. Although CD6 expression has been correlated with human autoimmune diseases, only a few therapeutic approaches are exploring this molecule as target in the clinic...
  15. Heap G, Yang J, Downes K, Healy B, Hunt K, Bockett N, et al. Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. Hum Mol Genet. 2010;19:122-34 pubmed publisher
    ..We also found convincing evidence for allelic imbalance at multiple reporter exonic SNPs in CD6 for two samples heterozygous at the multiple sclerosis-associated variant rs17824933, linking GWA findings with ..
  16. Stelletta C, De Nardo P, Santin F, Basso G, Michielotto B, Piccione G, et al. Effects of exposure to extremely low frequency electro-magnetic fields on circadian rhythms and distribution of some leukocyte differentiation antigens in dairy cows. Biomed Environ Sci. 2007;20:164-70 pubmed
    ..7 microT of ELFEMFs. Following haematological and immunologic parameters were measured in both groups: WBC, CD45R, CD6, CD4, CD8, CD21, and CD11B leukocyte antigen expression...
  17. Remacha A, Barrachina L, Álvarez Arguedas S, Ranera B, Romero A, Vázquez F, et al. Expression of genes involved in immune response and in vitro immunosuppressive effect of equine MSCs. Vet Immunol Immunopathol. 2015;165:107-18 pubmed publisher
    ..On the contrary, CD6 and VCAM1 expression increased in these cells...
  18. Perchoux J, Quotb A, Atashkhooei R, Azcona F, Ramírez Miquet E, Bernal O, et al. Current Developments on Optical Feedback Interferometry as an All-Optical Sensor for Biomedical Applications. Sensors (Basel). 2016;16: pubmed publisher
    ..The present paper is a review of the work in progress at UPC-CD6 and LAAS-CNRS related to the application of OFI to different aspects of biosensing, both in vivo and ex vivo...
  19. Wagner M, Bilinska M, Pokryszko Dragan A, Sobczynski M, Cyrul M, Kusnierczyk P, et al. ALCAM and CD6--multiple sclerosis risk factors. J Neuroimmunol. 2014;276:98-103 pubmed publisher
    ALCAM and CD6 may play an important role in the pathogenesis of multiple sclerosis (MS), since they are involved in the transmigration of leukocytes across the blood-brain barrier...
  20. Panyasai S, Fucharoen G, Fucharoen S. Known and new hemoglobin A2 variants in Thailand and implication for β-thalassemia screening. Clin Chim Acta. 2015;438:226-30 pubmed publisher
    ..Analysis of the remaining case identified a novel δ-Hb variant namely the Hb A2-Lampang [δ47(CD6)GAT→AAT; Asp→Asn] found in association with Hb E and α(+)-thalassemia...
  21. Aibar J, Martínez Florensa M, Castro P, Carrasco E, Escoda Ferran C, Fernández S, et al. Pattern of soluble CD5 and CD6 lymphocyte receptors in critically ill patients with septic syndromes. J Crit Care. 2015;30:914-9 pubmed publisher
    Soluble forms of CD5 and CD6 lymphocyte surface receptors (sCD5 and sCD6) are molecules that seem to prevent experimental sepsis when exogenously administered...
  22. Losacco M, de Almeida C, Hijo A, Bargi Souza P, Gama P, Nunes M, et al. High-fat diet affects gut nutrients transporters in hypo and hyperthyroid mice by PPAR-a independent mechanism. Life Sci. 2018;202:35-43 pubmed publisher
    ..Thus, mice were treated with fenofibrate, a PPAR-a agonist. HFD decreased GLUT2, PEPT1, FAT-CD6 and NPC1L1, but increased NHE3, while GLUT5 and FATP4 remained unaltered...
  23. Xu Z, Chang C, Li M, Zhang Q, Vasilescu E, D AGATI V, et al. ILT3.Fc-CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth. J Immunol. 2018;200:1207-1219 pubmed publisher
    ..CD166 displays strong heterophilic interaction with CD6 and weaker homophilic CD166-CD166 cell adhesion interaction. ILT3...
  24. Melone L, Petroselli M, Pastori N, Punta C. Functionalization of Cyclodextrins with N-Hydroxyphthalimide Moiety: A New Class of Supramolecular Pro-Oxidant Organocatalysts. Molecules. 2015;20:15881-92 pubmed publisher
    ..This work reports the synthesis of two β-cyclodextrin derivatives (CD5 and CD6) having a different degree of methylation and bearing a NHPI moiety...
  25. Gu J, Cai Y, Wen M, Shi Z, Kirillov A. A new series of Cd(ii) metal-organic architectures driven by soft ether-bridged tricarboxylate spacers: synthesis, structural and topological versatility, and photocatalytic properties. Dalton Trans. 2018;47:14327-14339 pubmed publisher
    ..2), {[Cd3(μ5-cpta)2(2,2'-bipy)3]·6H2O}n (3), {[Cd(μ3-cpta)(Hbpa)]·2H2O}n (4), {[Cd6(μ4-cpta)2(μ6-cpta)2(H2biim)2(H2O)6]·5H2O}n (5), [Cd3(μ4-cpta)2(μ-prz)(H2O)4]n (6), {[Cd3(μ4-dbba)2(phen)3]·..
  26. Enyindah Asonye G, Li Y, Xin W, Singer N, Gupta N, Fung J, et al. CD6 Receptor Regulates Intestinal Ischemia/Reperfusion-induced Injury by Modulating Natural IgM-producing B1a Cell Self-renewal. J Biol Chem. 2017;292:661-671 pubmed publisher
    ..b>CD6 was originally identified as a marker for T cells and was later found to be present on some subsets of B cells in ..
  27. Han J, Enyindah Asonye G, Lin F, Smith J. CD6 expression has no effect on atherosclerosis in apolipoprotein E-deficient mice. BMC Res Notes. 2018;11:229 pubmed publisher
    To determine if deficiency of CD6, a cell surface protein on lymphocytes that alters natural antibody production, increases atherosclerosis in ApoE-deficient mice fed a chow or a western-type diet...
  28. Jiang L, Fantoni G, Couzens L, Gao J, Plant E, Ye Z, et al. Comparative Efficacy of Monoclonal Antibodies That Bind to Different Epitopes of the 2009 Pandemic H1N1 Influenza Virus Neuraminidase. J Virol. 2016;90:117-28 pubmed publisher
    ..the present study, we evaluated the in vitro and in vivo efficacies of four monoclonal antibodies (MAbs): HF5 and CD6, which are specific to two different epitopes in the NA of 2009 pandemic H1N1 (pH1N1) virus, and 4E9 and 1H5, which ..
  29. Zheng M, Zhang L, Yu H, Hu J, Cao Q, Huang G, et al. Genetic polymorphisms of cell adhesion molecules in Behcet's disease in a Chinese Han population. Sci Rep. 2016;6:24974 pubmed publisher
    ..The expression of CD6 and CD11c was examined by real-time PCR and cytokine production was measured by ELISA...
  30. Martínez Florensa M, Consuegra Fernández M, Aranda F, Armiger Borràs N, Di Scala M, Carrasco E, et al. Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..The soluble form of the scavenger-like human CD6 lymphocyte receptor (shCD6) binds to key pathogenic components from Gram-positive and -negative bacteria and shows ..
  31. Shi K, Li M, Wang X, Li J, Karim M, Wang R, et al. Molecular survey of Enterocytozoon bieneusi in sheep and goats in China. Parasit Vectors. 2016;9:23 pubmed publisher
    ..A further four known genotypes (CD6, COS-I, BEB6, and J) and 22 novel genotypes (CHG1-CHG3, CHG5, CHG8, CHG10-CHG14, CHG16-CHG18, CHG20, CHG22, CHG24, ..
  32. Wu Q, Zhu X, Fu X, Yang J, Cao Z, Pu C. [Expression of Tim-3 on Peripheral CD56(+) NK Cells and ItsCorrelation with Liver Fibrosis in Patients withAdvanced Schistosomiasis]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2015;33:346-50 pubmed
    ..Tim-3 expression on CD6(+) NK cells from 28 patients with advanced schistosomiasis and 30 healthy controls was determined by flow cytometry...
  33. Schiza A, Wenthe J, Mangsbo S, Eriksson E, Nilsson A, Totterman T, et al. Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients. J Transl Med. 2017;15:79 pubmed publisher
    ..Stem cell factor (SCF), E-selectin, and CD6 correlated to enhanced overall survival while a high level of granulocytic myeloid-derived suppressor cells (gMDSCs)..
  34. Consuegra Fernández M, Lin F, Fox D, Lozano F. Clinical and experimental evidence for targeting CD6 in immune-based disorders. Autoimmun Rev. 2018;17:493-503 pubmed publisher
    b>CD6 is a cell surface glycoprotein expressed by most T cells and a subset of B cells that has incompletely-defined roles in regulation of lymphocyte development, selection, activation and differentiation...
  35. Brütting C, Emmer A, Kornhuber M, Staege M. A survey of endogenous retrovirus (ERV) sequences in the vicinity of multiple sclerosis (MS)-associated single nucleotide polymorphisms (SNPs). Mol Biol Rep. 2016;43:827-36 pubmed publisher
    ..The associated genes (CYP27B1, CD6, CD58, MPV17L2, IL12RB1, CXCR5, PTGER4, TAGAP, TYK2, ICAM3, CD86, GALC, GPR65 as well as the HLA DRB1*1501) are ..
  36. Orta Mascaró M, Consuegra Fernández M, Carreras E, Roncagalli R, Carreras Sureda A, Alvarez P, et al. CD6 modulates thymocyte selection and peripheral T cell homeostasis. J Exp Med. 2016;213:1387-97 pubmed publisher
    The CD6 glycoprotein is a lymphocyte surface receptor putatively involved in T cell development and activation...
  37. Wan H, Sultana I, Couzens L, Mindaye S, Eichelberger M. Assessment of influenza A neuraminidase (subtype N1) potency by ELISA. J Virol Methods. 2017;244:23-28 pubmed publisher
    ..The assays use mouse monoclonal antibodies (mAbs) 1H5 and CD6 to capture NAs of viruses, and a different mAb 4E9 to detect bound antigen...
  38. Zhang L, Li Y, Qiu W, Bell B, Dvorina N, Baldwin W, et al. Targeting CD6 for the treatment of experimental autoimmune uveitis. J Autoimmun. 2018;90:84-93 pubmed publisher
    b>CD6 is emerging as a new target for treating many pathological conditions in which T cells are integrally involved, but even the latest data from studies of CD6 gene engineered mice were still contradictory...
  39. Zheng Q, Li J, Qin L, Wei H, Cai L, Nong B. Gastrointestinal involvement by mantle cell lymphoma identified by biopsy performed during endoscopy: A case report. Medicine (Baltimore). 2018;97:e9799 pubmed publisher
    ..showed that the cells were positive for CyclinD1, BCL-2, CD20, CD21, and CD5; however, they were negative for CD3, CD6, CD10, and CD43. The patient refused to receive further treatment. Mantle cell lymphoma was conclusively diagnosed...
  40. Bughani U, Saha A, Kuriakose A, Nair R, Sadashivarao R, Venkataraman R, et al. T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab. PLoS ONE. 2017;12:e0180088 pubmed publisher
    b>CD6 is associated with T-cell modulation and is implicated in several autoimmune diseases...
  41. Sarukhan A, Martínez Florensa M, Escoda Ferran C, Carrasco E, Carreras E, Lozano F. Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor. Curr Drug Targets. 2016;17:640-50 pubmed
    b>CD6, one of the first antigens to be identified on T cells, is a membrane glycoprotein that physically associates with the antigen receptor complex...
  42. Takayama M, Taira T, Iguchi Ariga S, Ariga H. CDC6 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc/Max complex. FEBS Lett. 2000;477:43-8 pubmed
    ..In consequence, the E-box-dependent transcription activity of c-Myc was abrogated. These results suggest that, in addition to its DNA replication activity, CDC6 also has a role as a transcriptional suppressor of c-Myc. ..
  43. Singer N, Mitra R, Lialios F, Richardson B, Marks R, Pesando J, et al. CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes. Immunol Lett. 1997;58:9-14 pubmed
    The CD6 glycoprotein is expressed by T lymphocytes and is hypothesized to interact with one or more ligands expressed on antigen presenting cells (APCs)...
  44. Alonso R, Huerta V, de Leon J, Piedra P, Puchades Y, Guirola O, et al. Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody. Hybridoma (Larchmt). 2008;27:291-301 pubmed publisher
    ..b>CD6, a highly glycosylated membrane protein predominantly expressed on lymphocytes, contains three SRCR domains...
  45. Park T, Kim H, Kim J, Bae J, Cheong H, Park B, et al. Associations of CD6, TNFRSF1A and IRF8 polymorphisms with risk of inflammatory demyelinating diseases. Neuropathol Appl Neurobiol. 2013;39:519-30 pubmed publisher
    ..in European-origin populations have suggested associations of single-nucleotide polymorphisms (SNPs) in CD6, TNFRSF1A and IRF8 with MS...
  46. Shen Q, Björkesten J, Galli J, Ekman D, Broberg J, Nordberg N, et al. Strong impact on plasma protein profiles by precentrifugation delay but not by repeated freeze-thaw cycles, as analyzed using multiplex proximity extension assays. Clin Chem Lab Med. 2017;: pubmed publisher
    ..For samples stored at 4 °C, epidermal growth factor (EGF), NF-kappa-B essential modulator, SRC, interleukin 16 and CD6 increased the most, whereas the five most significantly increased proteins after storage at 22 °C were CD40 ..
  47. Kato Y, Tanaka Y, Hayashi M, Okawa K, Minato N. Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens. J Immunol. 2006;177:877-84 pubmed
    ..gammadelta T cells expressed CD6, a receptor of CD166, and CD6 and CD166 were recruited together to the center of synapse between gammadelta T cells ..
  48. Pai G, Pai A. Itolizumab - A New Biologic for Management of Psoriasis and Psoriatic Arthritis. Case Rep Dermatol. 2017;9:141-145 pubmed publisher
    ..The newly developed biologic itolizumab is a humanized recombinant anti-CD6 monoclonal antibody of IgG1 isotype that binds to domain 1 of CD6, thereby immunomodulating human lymphocytes ..
  49. Park E, Jeon S, Weon H, Cho H, Youn D. Activated leukocyte cell adhesion molecule is involved in excitatory synaptic transmission and plasticity in the rat spinal dorsal horn. Neurosci Lett. 2017;656:9-14 pubmed publisher
    ..Bath-application of ALCAM/Fc or CD6/Fc, the recombinant human IgG1-Fc chimeric proteins, specifically potentiated C-fiber-mediated ..
  50. Kofler D, Farkas A, von Bergwelt Baildon M, Hafler D. The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations. Curr Drug Targets. 2016;17:651-65 pubmed
    The cell surface glycoprotein CD6 is expressed on leukocytes and mediates T cell trafficking across endothelial cell barriers...
  51. Swaminathan B, Matesanz F, Cavanillas M, Alloza I, Otaegui D, Olascoaga J, et al. Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain. J Neuroimmunol. 2010;223:100-3 pubmed publisher
    ..e. TNFRSF1A, CD6 and IRF8, as novel risk factors for multiple sclerosis with genome-wide level of significance...
  52. Consuegra Fernández M, Julia M, Martínez Florensa M, Aranda F, Català C, Armiger Borràs N, et al. Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis. Cell Mol Immunol. 2018;15:898-906 pubmed publisher
    ..Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity...
  53. Alonso R, Buors C, Le Dantec C, Hillion S, Pers J, Saraux A, et al. Aberrant expression of CD6 on B-cell subsets from patients with Sjögren's syndrome. J Autoimmun. 2010;35:336-41 pubmed publisher
    b>CD6 is one of a pair of related genes encoding CD5-associated receptors on all T cells and a subset of B cells...
  54. Wang J, Pappas D, De Jager P, Pelletier D, de Bakker P, Kappos L, et al. Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Med. 2011;3:3 pubmed publisher
    ..The cumulative genetic risk established using currently available genome-wide association data provides important insights into disease heterogeneity and completeness of current knowledge in MS genetics. ..
  55. Krintel S, Essioux L, Wool A, Johansen J, Schreiber E, Zekharya T, et al. CD6 and syntaxin binding protein 6 variants and response to tumor necrosis factor alpha inhibitors in Danish patients with rheumatoid arthritis. PLoS ONE. 2012;7:e38539 pubmed publisher
    ..A 19 base pair insertion within the CD6 gene was associated with EULAR good response vs. no response (OR=4.43, 95% CI: 1.99-10.09, p=7...
  56. Escoda Ferran C, Carrasco E, Caballero Baños M, Miró Julià C, Martínez Florensa M, Consuegra Fernández M, et al. Modulation of CD6 function through interaction with Galectin-1 and -3. FEBS Lett. 2014;588:2805-13 pubmed publisher
    b>CD6 is a lymphocyte glycoprotein receptor that physically associates with the antigen-specific receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM...
  57. da Glória V, Martins de Araujo M, Mafalda Santos A, Leal R, de Almeida S, Carmo A, et al. T cell activation regulates CD6 alternative splicing by transcription dynamics and SRSF1. J Immunol. 2014;193:391-9 pubmed publisher
    The T cell-surface glycoprotein CD6 is a modulator of cellular responses and has been implicated in several autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis...
  58. Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, et al. Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. Nat Immunol. 2014;15:384-392 pubmed publisher
    ..The surface receptor CD6 was able to initiate its own signaling pathway by recruiting SLP-76 and the guanine nucleotide-exchange factor Vav1 ..
  59. Tsuge I, Utsumi K, Ueda R, Takamoto S, Takahashi T. Assignment of gene coding human T-cell differentiation antigen, Tp120, to chromosome 11. Somat Cell Mol Genet. 1985;11:217-22 pubmed
    A pan T-cell antigen with a molecular weight of 120 kilodaltons (kd) is recognized by a monoclonal antibody, Tp120, produced in our laboratories...
  60. Rodriguez P, Prada D, Moreno E, Aira L, Molinero C, Lopez A, et al. The anti-CD6 antibody itolizumab provides clinical benefit without lymphopenia in rheumatoid arthritis patients: results from a 6-month, open-label Phase I clinical trial. Clin Exp Immunol. 2017;: pubmed publisher
    Itolizumab is a humanized anti-CD6 monoclonal antibody (mAb) that has previously shown encouraging results, in terms of safety and positive clinical effects, in a 6-week monotherapy clinical trial conducted in rheumatoid arthritis (RA) ..
  61. Kobarg J, Whitney G, Palmer D, Aruffo A, Bowen M. Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains. Eur J Immunol. 1997;27:2971-80 pubmed
    b>CD6 is a cell surface glycoprotein that functions both as a co-stimulatory and adhesion receptor on T cells...
  62. Swaminathan B, Cuapio A, Alloza I, Matesanz F, Alcina A, García Barcina M, et al. Fine mapping and functional analysis of the multiple sclerosis risk gene CD6. PLoS ONE. 2013;8:e62376 pubmed publisher
    b>CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1...
  63. Brunner P, Suárez Fariñas M, He H, Malik K, Wen H, Gonzalez J, et al. The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins. Sci Rep. 2017;7:8707 pubmed publisher
    ..fractalkine/CX3CL1, CCL8, M-CSF, HGF), T-cell development/activation (CD40L, IL-7, CCL25, IL-2RB, IL-15RA, CD6) and angiogenesis (VEGF-A) were significantly increased only in AD...
  64. Enyindah Asonye G, Li Y, Ruth J, Spassov D, Hebron K, Zijlstra A, et al. CD318 is a ligand for CD6. Proc Natl Acad Sci U S A. 2017;114:E6912-E6921 pubmed publisher
    It has been proposed that CD6, an important regulator of T cells, functions by interacting with its currently identified ligand, CD166, but studies performed during the treatment of autoimmune conditions suggest that the CD6-CD166 ..
  65. Li Y, Singer N, Whitbred J, Bowen M, Fox D, Lin F. CD6 as a potential target for treating multiple sclerosis. Proc Natl Acad Sci U S A. 2017;114:2687-2692 pubmed publisher
    b>CD6 was established as a marker of T cells more than three decades ago, and recent studies have identified CD6 as a risk gene for multiple sclerosis (MS), a disease in which autoreactive T cells are integrally involved...
  66. Hem C, Ekornhol M, Granum S, Sundvold Gjerstad V, Spurkland A. CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein. Scand J Immunol. 2017;85:104-112 pubmed publisher
    ..pull-down and immunoprecipitation experiments, we here report novel interactions between the TSAd SH2 domain and CD6 phosphotyrosine (pTyr)629 and linker of activated T cells (LAT) pTyr171 , pTyr191 ..
  67. Brown M. CD6 as a Cell Surface Receptor and As a Target for Regulating Immune Responses. Curr Drug Targets. 2016;17:619-29 pubmed
    b>CD6 has been exploited as a drug target as its expression is restricted, primarily to T cells, it has a well characterised cell surface ligand, CD166 and regulates T cell activation through a long cytoplasmic tail...
  68. Chappell P, Garner L, Yan J, Metcalfe C, Hatherley D, Johnson S, et al. Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction. Structure. 2015;23:1426-1436 pubmed publisher
    b>CD6 is a transmembrane protein with an extracellular region containing three scavenger receptor cysteine rich (SRCR) domains...
  69. Santos R, Oliveira L, Carmo A. Tuning T Cell Activation: The Function of CD6 At the Immunological Synapse and in T Cell Responses. Curr Drug Targets. 2016;17:630-9 pubmed
    b>CD6 immunotherapy to treat psoriasis and rheumatoid arthritis has reached the clinical trial stage with apparent success, and targeting CD6 with mAbs is being used in several animal models of autoimmunity and neuroinflammation with ..
  70. Braun M, Müller B, Ter Meer D, Raffegerst S, Simm B, Wilde S, et al. The CD6 scavenger receptor is differentially expressed on a CD56 natural killer cell subpopulation and contributes to natural killer-derived cytokine and chemokine secretion. J Innate Immun. 2011;3:420-34 pubmed publisher
    The CD6 scavenger receptor is known to be expressed on virtually all T cells and is supposed to be involved in costimulation, synapse formation, thymic selection and leukocyte migration...
  71. . The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study. PLoS ONE. 2011;6:e18813 pubmed publisher
    ..identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 (TNFRSF1A) and rs17445836 (61.5 kb from IRF8)...
  72. Garcia Santana C, Tung J, Gulnik S. Human treg cells are characterized by low/negative CD6 expression. Cytometry A. 2014;85:901-8 pubmed publisher
    ..Herein, we present evidence that CD4+ CD25hi CD6(lo/-) nTreg have high expression of FOXP3and exhibit in vitro suppressive activity on CD8+ T-cell proliferation...
  73. Mowry E, Carey R, Blasco M, Pelletier J, Duquette P, Villoslada P, et al. Association of multiple sclerosis susceptibility variants and early attack location in the CNS. PLoS ONE. 2013;8:e75565 pubmed publisher
    ..46, 95% CI 0.22, 0.97, p?=?0.041), as were the TNFRSF1A and IL12A polymorphisms. The CD6 polymorphism conferred reduced odds of optic neuritis as an attack location (OR?=?0.69, 95% CI [0.49, 0.97], p?=?0...
  74. Bonet L, Farnós M, Martínez Florensa M, Martinez V, Lozano F. Identification of functionally relevant phoshorylatable serine clusters in the cytoplasmic region of the human CD6 lymphocyte surface receptor. FEBS Lett. 2013;587:2205-13 pubmed publisher
    b>CD6 is a transmembrane receptor expressed by all T and a subset of B lymphocytes, where it physically associates with the antigen-specific receptor to modulate activation and differentiation processes through still poorly understood ..
  75. Breuning J, Brown M. T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex. Mol Cell Biol. 2017;37: pubmed publisher
    The cell surface receptor CD6 regulates T cell activation in both activating and inhibitory manners...
  76. Oliveira M, Gonçalves C, Pinto M, Fabre S, Santos A, Lee S, et al. CD6 attenuates early and late signaling events, setting thresholds for T-cell activation. Eur J Immunol. 2012;42:195-205 pubmed publisher
    The T lineage glycoprotein CD6 is generally considered to be a costimulator of T-cell activation. Here, we demonstrate that CD6 significantly reduces early and late T-cell responses upon superantigen stimulation or TCR triggering by Abs...
  77. Swack J, Mier J, Romain P, Hull S, Rudd C. Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule. J Biol Chem. 1991;266:7137-43 pubmed
    b>CD6 (T12) is a 130-kDa glycoprotein present on the surface of human T cells...