CD59

Summary

Gene Symbol: CD59
Description: CD59 molecule (CD59 blood group)
Alias: 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20, CD59 glycoprotein, 1F5 antigen, 20 kDa homologous restriction factor, CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344), CD59 molecule, complement regulatory protein, Ly-6-like protein, MEM43 antigen, T cell-activating protein, human leukocyte antigen MIC11, lymphocytic antigen CD59/MEM43, membrane attack complex (MAC) inhibition factor, membrane attack complex inhibition factor, membrane inhibitor of reactive lysis, protectin, surface anitgen recognized by monoclonal antibody 16.3A5
Species: human
Products:     CD59

Top Publications

  1. Ninomiya H, Sims P. The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9. J Biol Chem. 1992;267:13675-80 pubmed
    The erythrocyte membrane inhibitor of the human terminal complement proteins, surface antigen CD59, has previously been shown to enter into a detergent-resistant complex with either the membrane-bound complex of C5b-8 or C5b-9 (Meri, S...
  2. Yamashina M, Ueda E, Kinoshita T, Takami T, Ojima A, Ono H, et al. Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1990;323:1184-9 pubmed
  3. Davies A, Simmons D, Hale G, Harrison R, Tighe H, Lachmann P, et al. CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J Exp Med. 1989;170:637-54 pubmed
    A novel cell surface antigen has been identified on a wide range of lymphoid cells and erythrocytes. A mAb YTH 53.1 (CD59) against this antigen enhanced the lysis of human red cells and lymphocytes by homologous complement...
  4. Bodian D, Davis S, Morgan B, Rushmere N. Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59. J Exp Med. 1997;185:507-16 pubmed
    The Ly-6 superfamily of cell surface molecules includes CD59, a potent regulator of the complement system that protects host cells from the cytolytic action of the membrane attack complex (MAC)...
  5. Rudd P, Morgan B, Wormald M, Harvey D, van den Berg C, Davis S, et al. The glycosylation of the complement regulatory protein, human erythrocyte CD59. J Biol Chem. 1997;272:7229-44 pubmed
    Human erythrocyte CD59 contains N- and O-glycans and a glycosylphosphatidylinositol (GPI) anchor, all of which have been analyzed in this study...
  6. Richaud Patin Y, Pérez Romano B, Carrillo Maravilla E, Rodriguez A, Simon A, Cabiedes J, et al. Deficiency of red cell bound CD55 and CD59 in patients with systemic lupus erythematosus. Immunol Lett. 2003;88:95-9 pubmed
    CD55 and CD59 are glycosylphosphatidylinositol-anchored proteins with complement inhibitory properties. Autoimmune hemolytic anemia (AIHA) has been associated with antiphospholipid antibodies (APLA)...
  7. Qin X, Goldfine A, Krumrei N, Grubissich L, Acosta J, Chorev M, et al. Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes. Diabetes. 2004;53:2653-61 pubmed
    ..We proposed that in human diabetes, inhibition by glycation of the complement regulatory protein CD59 increases deposition of the membrane attack complex (MAC) of complement, contributing to the higher vascular risk...
  8. Alegretti A, Mucenic T, Merzoni J, Faulhaber G, Silla L, Xavier R. Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients. Cell Immunol. 2010;265:127-32 pubmed publisher
    CD55 and CD59 are glycosylphosphatidylinositol-anchored proteins with complement inhibitory properties. CD55 inhibits the formation of C3 convertases, and CD59 prevents the terminal polymerisation of the membrane attack complex...
  9. Hahn W, Menu E, Bothwell A, Sims P, Bierer B. Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. Science. 1992;256:1805-7 pubmed
    ..We have identified CD59, a glycoprotein with complement-inhibitory function, as a second physiological ligand for CD2...

More Information

Publications108 found, 100 shown here

  1. Rooney I, Morgan B. Protection of human amniotic epithelial cells (HAEC) from complement-mediated lysis: expression on the cells of three complement inhibitory membrane proteins. Immunology. 1990;71:308-11 pubmed
    ..cells (HAEC) were found by immunofluorescence microscopy to express three complement inhibitory membrane proteins, CD59 antigen, decay-accelerating factor (DAF) and membrane attack complex (MAC) inhibitory protein (MIP), on their ..
  2. Kieffer B, Driscoll P, Campbell I, Willis A, van der Merwe P, Davis S. Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. Biochemistry. 1994;33:4471-82 pubmed
    The cell surface antigen CD59 is an inhibitor of complement-mediated lysis and a member of the Ly6 superfamily (Ly6SF) of cysteine-rich cell-surface molecules whose sequences are related to those of snake venom neurotoxins...
  3. Fletcher C, Harrison R, Lachmann P, Neuhaus D. Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. Structure. 1994;2:185-99 pubmed
    b>CD59 is a cell-surface glycoprotein that protects host cells from complement-mediated lysis by binding to and preventing the normal functioning of the complement proteins C8 and/or C9 which form part of a membrane penetrating assembly ..
  4. Cuida M, Legler D, Eidsheim M, Jonsson R. Complement regulatory proteins in the salivary glands and saliva of Sjögren's syndrome patients and healthy subjects. Clin Exp Rheumatol. 1997;15:615-23 pubmed
    The aim of this study was to examine the presence of the complement regulatory proteins protectin (CD59), decay accelerating factor (CD55), membrane cofactor protein (CD46) and clusterin (SP-40,40) in connection with the autoimmune ..
  5. Huang Y, Qiao F, Abagyan R, Hazard S, Tomlinson S. Defining the CD59-C9 binding interaction. J Biol Chem. 2006;281:27398-404 pubmed
    b>CD59 is a membrane glycoprotein that regulates formation of the cytolytic membrane attack complex (MAC or C5b-9) on host cell membranes...
  6. Ramo K, Cashman S, Kumar Singh R. Evaluation of adenovirus-delivered human CD59 as a potential therapy for AMD in a model of human membrane attack complex formation on murine RPE. Invest Ophthalmol Vis Sci. 2008;49:4126-36 pubmed publisher
    ..The hypothesis that local overexpression of human CD59 (hCD59) delivered by an adenovirus (Ad) vector to primary murine RPE cells in vitro, RPE in vivo, or cornea ex vivo ..
  7. Bonnon C, Wendeler M, Paccaud J, Hauri H. Selective export of human GPI-anchored proteins from the endoplasmic reticulum. J Cell Sci. 2010;123:1705-15 pubmed publisher
    ..Using siRNA-based silencing, we identified that ER-to-Golgi transport of the human GPI-anchored protein CD59 requires Sec24, with preference for the Sec24C and Sec24D isoforms, and the recycling transmembrane protein complex ..
  8. Wickham S, Hotze E, Farrand A, Polekhina G, Nero T, Tomlinson S, et al. Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J Biol Chem. 2011;286:20952-62 pubmed publisher
    b>CD59 is a glycosylphosphatidylinositol-anchored protein that inhibits the assembly of the terminal complement membrane attack complex (MAC) pore, whereas Streptococcus intermedius intermedilysin (ILY), a pore forming cholesterol-dependent ..
  9. Mahtout H, Curt S, Chandad F, Rouabhia M, Grenier D. Effect of periodontopathogen lipopolysaccharides and proinflammatory cytokines on CD46, CD55, and CD59 gene/protein expression by oral epithelial cells. FEMS Immunol Med Microbiol. 2011;62:295-303 pubmed publisher
    Membrane-anchored complement regulatory proteins (CRPs), including CD46, CD55, and CD59, protect host cells from complement attack...
  10. Gandhi J, Cashman S, Kumar Singh R. Soluble CD59 expressed from an adenovirus in vivo is a potent inhibitor of complement deposition on murine liver vascular endothelium. PLoS ONE. 2011;6:e21621 pubmed publisher
    ..Inhibition of the terminal step of complement activation, i.e. formation of the membrane attack complex, using CD59 has the advantage of retaining the upstream processes of the complement cascade necessary for fighting pathogens ..
  11. Giddings K, Zhao J, Sims P, Tweten R. Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin. Nat Struct Mol Biol. 2004;11:1173-8 pubmed
    ..here that ILY, via its domain 4 structure, binds to the glycosyl-phosphatidylinositol-linked membrane protein human CD59 (huCD59). CD59 is an inhibitor of the membrane attack complex of human complement...
  12. Barros M, Yamamoto M, Figueiredo M, Cançado R, Kimura E, Langhi D, et al. Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-alpha,beta on monocytes from patients with warm autoimmune hemolytic anemia. Transfusion. 2009;49:154-60 pubmed publisher
    ..In contrast, complement-inhibitory proteins such as CD35, CD55, and CD59 may protect RBCs against the lysis by complement...
  13. Wu G, Hu W, Shahsafaei A, Song W, Dobarro M, Sukhova G, et al. Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. Circ Res. 2009;104:550-8 pubmed publisher
    ..b>CD59 is a key regulator of complement membrane attack complex (MAC) assembly...
  14. Hughes T, Ross K, Cowan G, Sivasankar B, Harris C, Mitchell T, et al. Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59. Mol Immunol. 2009;46:1561-7 pubmed publisher
    ..of the bacterial cytolysin intermedilysin is explained by its requirement for the human complement regulator CD59 as the primary receptor...
  15. LaRocca T, Stivison E, Hod E, Spitalnik S, Cowan P, Randis T, et al. Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes. MBio. 2014;5:e01251-14 pubmed publisher
    ..family of pore-forming toxins (PFTs) has an unusually narrow host range due to a requirement for binding to human CD59 (hCD59), a glycosylphosphatidylinositol (GPI)-linked complement regulatory molecule...
  16. Lee M, Jones T, Song D, Jang J, Jung J, Gao S. Exploitation of the complement system by oncogenic Kaposi's sarcoma-associated herpesvirus for cell survival and persistent infection. PLoS Pathog. 2014;10:e1004412 pubmed publisher
    ..the alternative complement pathway through down-regulation of cell surface complement regulatory proteins CD55 and CD59. Interestingly, complement activation caused minimal cell death but promoted the survival of latently KSHV-infected ..
  17. Yan W, Che L, Jiang J, Yang F, Duan Q, Song H, et al. Depletion of complement system immunity in patients with myocardial infarction. Mol Med Rep. 2016;14:5350-5356 pubmed publisher
    ..component), CR1, integrin ?M, integrin ?X, integrin ?2, C5aR, CRIg (complement receptors) and CD46, CD55 and CD59 (complement regulators) were significantly higher, compared with the respective genes in the SA patients and ..
  18. Wang L, Kondo N, Cano M, Ebrahimi K, Yoshida T, Barnett B, et al. Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells. Free Radic Biol Med. 2014;70:155-66 pubmed publisher
    ..Whereas CFH protein was not altered by CSE, the cell membrane regulator proteins CD46, CD55, and CD59 were decreased, and C3a and C3b, but not iC3b, were increased compared to controls...
  19. Feng G, Li J, Zheng M, Yang Z, Liu Y, Zhang S, et al. Hepatitis B virus X protein up-regulates C4b-binding protein ? through activating transcription factor Sp1 in protection of hepatoma cells from complement attack. Oncotarget. 2016;7:28013-26 pubmed publisher
    ..We previously showed that HBx protected hepatoma cells from complement attack by activation of CD59. Moreover, in this study we found that HBx protected hepatoma cells from complement attack by activation of C4b-..
  20. Mödinger Y, Rapp A, Vikman A, Ren Z, Fischer V, Bergdolt S, et al. Reduced Terminal Complement Complex Formation in Mice Manifests in Low Bone Mass and Impaired Fracture Healing. Am J Pathol. 2019;189:147-161 pubmed publisher
    ..deficient for complement component 6 (C6), an essential component for TCC assembly, and mice with a knockout of CD59, which is a negative regulator of TCC formation, were used in this study...
  21. Shi H, Williams J, Guo L, Stampoulis D, Francesca Cordeiro M, Moss S. Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. Apoptosis. 2015;20:433-43 pubmed publisher
    ..661W cone photoreceptors were exposed to complete normal human serum following antibody blockade of CD59. Apoptosis induction was assessed morphologically, by flow cytometry, and on western blotting by probing for ..
  22. Gundala N, Naidu V, Das U. Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo. Nutrition. 2017;35:61-80 pubmed publisher
    ..LOX) inhibitors and antiinflammatory metabolite of AA and DHA, lipoxin A4 (LXA4), and resolvin D2 and protectin, respectively against STZ-induced cytotoxicity to RIN5 F cells in vitro and LXA4 against T1- and T2DM in vivo ..
  23. Vaisar T, Durbin Johnson B, Whitlock K, Babenko I, Mehrotra R, Rocke D, et al. Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes. Diabetes Care. 2018;41:2361-2369 pubmed publisher
    ..1 years and 40 died over a median 3.6 years. Higher urine CD59, an inhibitor of terminal complement complex formation, was associated with a lower risk of ESRD (hazard ratio [HR] ..
  24. Cao Q, Ni Y, Cao D, Tian D, Yugo D, Heffron C, et al. Recombinant Porcine Reproductive and Respiratory Syndrome Virus Expressing Membrane-Bound Interleukin-15 as an Immunomodulatory Adjuvant Enhances NK and γδ T Cell Responses and Confers Heterologous Protection. J Virol. 2018;92: pubmed publisher
    ..the incorporated cytokines to the cell membrane surface by fusing the genes with a membrane-targeting signal from CD59. The recombinant MLV virus expressing the membrane-bound IL-15 cytokine greatly enhanced NK cell and γδ T cell ..
  25. Hoffman W, Artlett C, Boodhoo D, Gilliland M, Ortiz L, Mulder D, et al. Markers of immune-mediated inflammation in the brains of young adults and adolescents with type 1 diabetes and fatal diabetic ketoacidosis. Is there a difference?. Exp Mol Pathol. 2017;102:505-514 pubmed publisher
    ..03). CD59, a MAC assembly inhibitory protein was absent, possibly suppressed by the hyperglycemia in the teenagers but was ..
  26. Sawada R, Ohashi K, Anaguchi H, Okazaki H, Hattori M, Minato N, et al. Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes. DNA Cell Biol. 1990;9:213-20 pubmed
    To identify the primary structure of CD59 antigen and to elucidate its function, a full-length cDNA clone of CD59 was isolated. The cDNA sequence contained an open reading frame that encodes an 128-amino-acid peptide...
  27. Kolicheski A, Johnson G, Mhlanga Mutangadura T, Taylor J, Schnabel R, Kinoshita T, et al. A homozygous PIGN missense mutation in Soft-Coated Wheaten Terriers with a canine paroxysmal dyskinesia. Neurogenetics. 2017;18:39-47 pubmed publisher
    ..involved in the biosynthesis of glycosylphosphatidylinositol (GPI), which anchors a variety of proteins including CD59 to the cell surface. Flow cytometry of PIGN-knockout HEK239 cells expressing recombinant human PIGN with the c...
  28. Bora N, Gobleman C, Atkinson J, Pepose J, Kaplan H. Differential expression of the complement regulatory proteins in the human eye. Invest Ophthalmol Vis Sci. 1993;34:3579-84 pubmed
    ..protein (MCP, CD46), decay accelerating factor (DAF, CD55), and membrane attack complex inhibiting protein (CD59). This study was undertaken to analyze the expression of these proteins in the normal human eye...
  29. Gustafsson D, Andersson E, Hu Y, Marttila M, Lindman K, Strand M, et al. Adenovirus 11p downregulates CD46 early in infection. Virology. 2010;405:474-82 pubmed publisher
    ..The complement regulatory factors CD55 and CD59 were also reduced to a significant extent as a consequence of Ad11p binding to K562 cells...
  30. Xia H, Chen L, Liu H, Sun Z, Yang W, Yang Y, et al. Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype. Sci Rep. 2017;7:99 pubmed publisher
    ..Here, we sought to evaluate whether Protectin DX (PDX, an isomer of Protecin D1), a newly identified lipid mediator, could protect mice against sepsis and ..
  31. Davis E, Kim J, Menasche B, Sheppard J, Liu X, Tan A, et al. Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins. Cell Rep. 2015;11:1727-36 pubmed publisher
    ..available haploid genetics approach to dissect GPI-AP pathways in human cells using prion protein (PrP) and CD59 as model molecules...
  32. Hopperton K, Trépanier M, James N, Chouinard Watkins R, Bazinet R. Fish oil feeding attenuates neuroinflammatory gene expression without concomitant changes in brain eicosanoids and docosanoids in a mouse model of Alzheimer's disease. Brain Behav Immun. 2018;69:74-90 pubmed publisher
    ..b>Protectin, maresin and D and E series resolvins were not detected in any sample...
  33. Zhu X, Gao M, Ren S, Wang Q, Lin C. Activity after site-directed mutagenesis of CD59 on complement-mediated cytolysis. Cell Mol Immunol. 2008;5:141-6 pubmed publisher
    b>CD59 may inhibit the cytolytic activity of complement by binding to C8/C9 and protect host cell membranes against homologous membrane attack complex (MAC)...
  34. Kim Y, Lim J, Kim M, Kim Y, Lee J, Han K. Quantitation of CD55 and CD59 expression on reticulocytes and mature erythrocytes in paroxysmal nocturnal hemoglobinuria, aplastic anemia, and healthy control subjects. Ann Clin Lab Sci. 2010;40:226-32 pubmed
    ..We quantified CD55 and CD59 molecules expressed on normal reticulocytes and mature erythrocytes of paroxysmal nocturnal hemoglobinuria (PNH), ..
  35. Brodsky R. Complement in hemolytic anemia. Blood. 2015;126:2459-65 pubmed publisher
    ..hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55...
  36. Hanson M, Liu F, Dai S, Kearns A, Qin X, Bryda E. Rapid conditional targeted ablation model for hemolytic anemia in the rat. Physiol Genomics. 2016;48:626-32 pubmed publisher
    ..We have developed an ablation system based on creating genetically modified animals that express human CD59 (hCD59), a membrane receptor, and administering intermedilysin (ILY), a toxin produced by Streptococcus intermedius,..
  37. Gobbetti T, Dalli J, Colas R, Federici Canova D, Aursnes M, Bonnet D, et al. Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. Proc Natl Acad Sci U S A. 2017;114:3963-3968 pubmed publisher
    ..fatty acids in human IBD colon biopsies, quantifying a significant up-regulation of the resolvin and protectin pathway compared with normal gut tissue...
  38. Figueroa Jiménez L, González Márquez A, Alicea Guevara R, Santiago Casiano M, de la Paz López M, Negrón Garcia L, et al. A Hispanic female patient with heartburn: A rare presentation of Paroxysmal Nocturnal Hemoglobinuria. Bol Asoc Med P R. 2015;107:9-12 pubmed
    ..Peripheral blood flow cytometry assays revealed diminished expression of CD55 and CD59 on the erythrocytes, granulocytes and monocytes...
  39. Freitas Leal J, Adjobo Hermans M, Brock R, Bosman G. Acetylcholinesterase provides new insights into red blood cell ageing in vivo and in vitro. Blood Transfus. 2017;15:232-238 pubmed publisher
    ..b>CD59, another GPI-linked protein that protects against complement-induced removal, also remains constant during storage...
  40. Watts M, Dankert J, Morgan E. Isolation and characterization of a membrane-attack-complex-inhibiting protein present in human serum and other biological fluids. Biochem J. 1990;265:471-7 pubmed
    ..Depletion of MIP from plasma resulted in enhancement of the lytic capacity of the plasma on heterologous erythrocytes. ..
  41. Laranjeira S, Symmonds M, Palace J, Payne S, Orlowski P. A mathematical model of cellular swelling in Neuromyelitis optica. J Theor Biol. 2017;433:39-48 pubmed publisher
    ..The model was further adapted to simulate the therapeutic potential of CD59. It was found that there is a threshold of CD59 concentration that can prevent the swelling of astrocytes...
  42. Fredman G, Li Y, Dalli J, Chiang N, Serhan C. Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. Sci Rep. 2012;2:639 pubmed publisher
    ..g. protectin D1. Resolvin (Rv)E1 and RvD1 (1?nM) reduced miR-219-5p in human macrophages, not shared by RvD2 or PD1...
  43. Buurma A, Cohen D, Veraar K, Schonkeren D, Claas F, Bruijn J, et al. Preeclampsia is characterized by placental complement dysregulation. Hypertension. 2012;60:1332-7 pubmed publisher
    ..Furthermore, the mRNA expression of the complement regulatory proteins CD55 and CD59 was significantly upregulated in preeclampsia...
  44. Cheng Y, Gao M. The effect of glycation of CD59 on complement-mediated cytolysis. Cell Mol Immunol. 2005;2:313-7 pubmed
    ..In present study, we demonstrated by site-directed mutagenesis that mutated CD59 was more susceptible to glycation-inactivation for hyperglycemia...
  45. Ratajczak M, Borkowska S, Mierzejewska K, Kucia M, Mendek Czajkowska E, Suszynska M, et al. Further evidence that paroxysmal nocturnal haemoglobinuria is a disorder of defective cell membrane lipid rafts. J Cell Mol Med. 2015;19:2193-201 pubmed publisher
    ..which is required for proper expression on the cell surface of two inhibitors of the complement cascade, CD55 and CD59. The absence of these markers from the surface of blood cells, including erythrocytes, makes the cells susceptible ..
  46. Sommaggio R, Bello Gil D, Perez Cruz M, Brokaw J, Manez R, Costa C. Genetic engineering strategies to prevent the effects of antibody and complement on xenogeneic chondrocytes. Eur Cell Mater. 2015;30:258-70 pubmed
    ..were isolated from non-transgenic, single and double transgenic pigs expressing HT and moderate levels of human CD59 (hCD59) and their response to human serum was assessed...
  47. Ghosh P, Luque Fernández M, Vaidya A, Ma D, Sahoo R, Chorev M, et al. Plasma Glycated CD59, a Novel Biomarker for Detection of Pregnancy-Induced Glucose Intolerance. Diabetes Care. 2017;40:981-984 pubmed publisher
    Plasma glycated CD59 (pGCD59) is an emerging biomarker in diabetes...
  48. Sugita Y, Tobe T, Oda E, Tomita M, Yasukawa K, Yamaji N, et al. Molecular cloning and characterization of MACIF, an inhibitor of membrane channel formation of complement. J Biochem. 1989;106:555-7 pubmed
    Human erythrocytes contain a membrane protein, MACIF, which inhibits the formation of a membrane attack complex (MAC) of complement. We have cloned and sequenced the complementary DNA of MACIF messenger RNA...
  49. Nakamura M, Okada H, Sasaki H, Yoshida K, Kamada M, Okada N, et al. Quantification of the CD55 and CD59, membrane inhibitors of complement on HIV-1 particles as a function of complement-mediated virolysis. Microbiol Immunol. 1996;40:561-7 pubmed
    ..the availability of the V3-loop of gp120 relative to the complement regulatory proteins, CD55 (DAF) and CD59 (HRF20) molecules on HIV. The results demonstrate that CD55 and CD59 exist on HIV virions, along with gp120 molecules...
  50. Moskovich O, Fishelson Z. Live cell imaging of outward and inward vesiculation induced by the complement c5b-9 complex. J Biol Chem. 2007;282:29977-86 pubmed
    ..MAC formation is controlled by CD59, a ubiquitously expressed membrane complement regulator...
  51. Jeanneau C, Rufas P, Rombouts C, Giraud T, Dejou J, About I. Can Pulp Fibroblasts Kill Cariogenic Bacteria? Role of Complement Activation. J Dent Res. 2015;94:1765-72 pubmed publisher
    ..The observed MAC formation and its lethal effects were significantly reduced when CD59, an inhibitor of MAC formation, was added...
  52. Sugita Y, Nakano Y, Oda E, Noda K, Tobe T, Miura N, et al. Determination of carboxyl-terminal residue and disulfide bonds of MACIF (CD59), a glycosyl-phosphatidylinositol-anchored membrane protein. J Biochem. 1993;114:473-7 pubmed
    b>MACIF (CD59) is a glycosyl-phosphatidylinositol (GPI)-anchored membrane glycoprotein which inhibits the formation of membrane attack complex of human complement. MACIF prepared from human erythrocyte membranes was digested with pronase...
  53. Clayton A, Harris C, Court J, Mason M, Morgan B. Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur J Immunol. 2003;33:522-31 pubmed
    ..We have examined the expression and functional roles of the membrane regulators of complement (CD46, CD55 and CD59) on antigen-presenting cell-derived exosomes...
  54. Wang Z, Guo W, Liu Y, Gong Y, Ding X, Shi K, et al. Low expression of complement inhibitory protein CD59 contributes to humoral autoimmunity against astrocytes. Brain Behav Immun. 2017;65:173-182 pubmed publisher
    ..The cause of such tissue-specific immune response remains largely unknown. We confirmed here that CD59, an inhibitory regulator of the complement membrane attack complex, is expressed and co-localized with aquaporin 4 ..
  55. Höchsmann B, Schrezenmeier H. Congenital CD59 Deficiency. Hematol Oncol Clin North Am. 2015;29:495-507 pubmed publisher
    The severe clinical symptoms of inherited CD59 deficiency confirm the importance of CD59 as essential complement regulatory protein for protection of cells against complement attack, in particular protection of hematopoietic cells and ..
  56. Okada H, Nagami Y, Takahashi K, Okada N, Hideshima T, Takizawa H, et al. 20 KDa homologous restriction factor of complement resembles T cell activating protein. Biochem Biophys Res Commun. 1989;162:1553-9 pubmed
    ..The amino acid sequence deduced from its coding base sequence resembles that of T cell activating protein, most conspicuously in cysteine residues, 10 out of 11 of which occupy identical positions in an overall ..
  57. Wang M, Li L, Guo Q, Zhang S, Ji D, Li H. Identification and expression of a new Ly6 gene cluster in zebrafish Danio rerio, with implications of being involved in embryonic immunity. Fish Shellfish Immunol. 2016;54:230-40 pubmed publisher
    ..Ly2.1-3 all possess a conserved LU domain and adopt similar three-finger structure with human CD59, SLURP1 and other Ly6 family members. Ly2...
  58. Thiffault I, Zuccarelli B, Welsh H, Yuan X, Farrow E, Zellmer L, et al. Hypotonia and intellectual disability without dysmorphic features in a patient with PIGN-related disease. BMC Med Genet. 2017;18:124 pubmed publisher
    ..181G > T (p.Glu61*) and c.284G > A (p.Arg95Gln). Analysis of FLAER and anti-CD59 by flow-cytometry demonstrated a shift in this patient's granulocytes, confirming a glycosylphosphatidylinositol-..
  59. Rother R, Zhao J, Zhou Q, Sims P. Elimination of potential sites of glycosylation fails to abrogate complement regulatory function of cell surface CD59. J Biol Chem. 1996;271:23842-5 pubmed
    b>CD59 is a glycosylphosphatidylinositol-anchored membrane glycoprotein that serves as the principle cellular inhibitor of the C5b-9 membrane attack complex (MAC) of human complement...
  60. Fu X, Ju J, Lin Z, Xiao W, Li X, Zhuang B, et al. Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice. Sci Rep. 2016;6:30239 pubmed publisher
    ..of MAC has been previously investigated by using either the mice deficient in C5 and C6, or MAC's regulator CD59. However, there is no available C9 deficient mice (mC9(-/-)) for directly dissecting the role of C5b-9 in the ..
  61. Füreder W, Agis H, Willheim M, Bankl H, Maier U, Kishi K, et al. Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells. J Immunol. 1995;155:3152-60 pubmed
    ..membrane cofactor protein (CD46), decay-accelerating factor (CD55), and membrane attack complex inhibitory factor (CD59), as well as the previously recognized CR1 (CD35), CR3 alpha (CD11b), CR4 alpha (CD11c), and CR3/4 beta (CD18)...
  62. Bennet W, Björkland A, Sundberg B, Brandhorst D, Brendel M, Richards A, et al. Expression of complement regulatory proteins on islets of Langerhans: a comparison between human islets and islets isolated from normal and hDAF transgenic pigs. Transplantation. 2001;72:312-9 pubmed
    ..We conclude that protection from complement-mediated lysis will be important in the context of intraportal pig-to-human islet transplantation, and expression of a human RCA on islet cells should be beneficial in this context. ..
  63. Füst A, Pallinger E, Stündl A, Kovacs E, Imre L, Toth S, et al. Both freshly prepared and frozen-stored amniotic membrane cells express the complement inhibitor CD59. ScientificWorldJournal. 2012;2012:815615 pubmed publisher
    ..We measured cell surface expression of CD59, a membrane-bound complement inhibitor on the cells of freshly prepared and cryopreserved amniotic membrane...
  64. Ghosh P, Vaidya A, Sahoo R, Goldfine A, Herring N, Bry L, et al. Glycation of the complement regulatory protein CD59 is a novel biomarker for glucose handling in humans. J Clin Endocrinol Metab. 2014;99:E999-E1006 pubmed publisher
    Human CD59, an inhibitor of the membrane attack complex of complement, is inactivated by glycation. Glycation inactivation of CD59 enhances complement-mediated injury in target organs of diabetes complications...
  65. Xiao K, Fang Z, Gao X, Zhao J, Huang R, Xie M. Membrane complement regulatory protein reduces the damage of transplanting autologous bone marrow mesenchymal stem cells by suppressing the activation of complement. Injury. 2017;48:2089-2094 pubmed publisher
    ..We also found that mCRPs CD55 and CD59 overexpressions can resist the cytotoxicity induced by complement activation, while mCRPs CD55 and CD59 knockdown ..
  66. Bickmore W, Longbottom D, Oghene K, Fletcher J, van Heyningen V. Colocalization of the human CD59 gene to 11p13 with the MIC11 cell surface antigen. Genomics. 1993;17:129-35 pubmed
    The human CD59 gene encodes a cell surface antigen detected by MEM43 and other antibodies. It has homology to the mouse Ly-6 genes that map on mouse chromosome 15 and are involved in lymphocyte signal transduction...
  67. Meri S, Lehto T, Sutton C, Tyynela J, Baumann M. Structural composition and functional characterization of soluble CD59: heterogeneity of the oligosaccharide and glycophosphoinositol (GPI) anchor revealed by laser-desorption mass spectrometric analysis. Biochem J. 1996;316 ( Pt 3):923-35 pubmed
    CD59 (protectin) is a glycophosphoinositol (GPI)-anchored inhibitor of the membrane attack complex of complement found on blood cells, endothelia and epithelial cells...
  68. Chong Y, Lee M. Expression of complement inhibitor protein CD59 in human neuronal and glial cell lines treated with HIV-1 gp41 peptides. J Neurovirol. 2000;6:51-60 pubmed
    ..HIV-1 transmembrane envelope protein gp41 on expression of the membrane inhibitor of complement mediated cytolysis (CD59) was assessed in human neuronal (SK-N-SH) and astroglial (T98G) cell lines...
  69. Storstein A, Knudsen A, Bjørge L, Meri S, Vedeler C. Heterogeneous expression of CD59 on human Purkinje cells. Neurosci Lett. 2004;362:21-5 pubmed
    The expression of CD59 and other complement regulators was studied in human cerebellum from 14 individuals with no cerebellar pathology, from one patient with multiple sclerosis (MS) and from two patients with paraneoplastic cerebellar ..
  70. Leath K, Johnson S, Roversi P, Hughes T, Smith R, Mackenzie L, et al. High-resolution structures of bacterially expressed soluble human CD59. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007;63:648-52 pubmed
    b>CD59 is a membrane-bound glycoprotein that protects host cells from lysis by inhibiting the terminal pathway of complement, preventing the formation and insertion of the membrane attack complex (MAC)...
  71. Qu Z, Liang X, Liu Y, Du J, Liu S, Sun W. Hepatitis B virus sensitizes hepatocytes to complement-dependent cytotoxicity through downregulating CD59. Mol Immunol. 2009;47:283-9 pubmed publisher
    ..b>CD59 mRNA, which encodes an important complement regulatory protein (CRP) expressed on cell surface, was found to be ..
  72. Hu W, Yu Q, Hu N, Byrd D, Amet T, Shikuma C, et al. A high-affinity inhibitor of human CD59 enhances complement-mediated virolysis of HIV-1: implications for treatment of HIV-1/AIDS. J Immunol. 2010;184:359-68 pubmed publisher
    ..The presence of complement regulators including CD59 on the external surface of the viral envelope confers resistance to complement-mediated virolysis, which may ..
  73. Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, et al. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-?B signaling to protect breast cancer cells from complement attack. FEBS Lett. 2012;586:766-71 pubmed publisher
    ..cells from CDC by upregulating membrane-bound complement regulatory protein (mCRPs), including CD46, CD55 and CD59. We found that HBXIP upregulated mCRPs through activating p-ERK1/2/NF-?B...
  74. Du Y, Teng X, Wang N, Zhang X, Chen J, Ding P, et al. NF-?B and enhancer-binding CREB protein scaffolded by CREB-binding protein (CBP)/p300 proteins regulate CD59 protein expression to protect cells from complement attack. J Biol Chem. 2014;289:2711-24 pubmed publisher
    ..b>CD59 is the sole membrane complement regulatory protein (mCRP) that restricts MAC assembly...
  75. Asimakopoulos J, Terpos E, Papageorgiou L, Kampouropoulou O, Christoulas D, Giakoumis A, et al. The presence of CD55- and/or CD59-deficient erythrocytic populations in patients with rheumatic diseases reflects an immune-mediated bone-marrow derived phenomenon. Med Sci Monit. 2014;20:123-39 pubmed publisher
    ..as shown in autoimmune diseases where complement activation has been associated with diminished CD55 and/or CD59 expression on peripheral blood cell membranes...
  76. Song G, Song G, Ni H, Gu L, Liu H, Chen B, et al. Deregulated expression of miR-224 and its target gene: CD59 predicts outcome of diffuse large B-cell lymphoma patients treated with R-CHOP. Curr Cancer Drug Targets. 2014;14:659-70 pubmed
    ..Using bioinformatics prediction and luciferase report assays, we demonstrated that miR-224 directly down-regulated CD59 expression by binding to its 3'-untranslated region...
  77. Yang K, Lan J, Shepherd N, Hu N, Xing Y, Byrd D, et al. Blockage of CD59 Function Restores Activities of Neutralizing and Nonneutralizing Antibodies in Triggering Antibody-Dependent Complement-Mediated Lysis of HIV-1 Virions and Provirus-Activated Latently Infected Cells. J Virol. 2015;89:9393-406 pubmed publisher
    ..Blockage of the biological function of RCA members, particularly CD59 (a key RCA member that controls formation of the membrane attack complex at the terminal stage of the complement ..
  78. Zeis T, Enz L, Schaeren Wiemers N. The immunomodulatory oligodendrocyte. Brain Res. 2016;1641:139-148 pubmed publisher
    ..g. C1s, C2 and C3, C1R), complement regulatory molecules (e.g. CD46, CD55, CD59), tetraspanins (e.g. TSPAN2), neuroimmune regulatory proteins (e.g...
  79. Komura N, Suzuki K, Ando H, Konishi M, Koikeda M, Imamura A, et al. Raft-based interactions of gangliosides with a GPI-anchored receptor. Nat Chem Biol. 2016;12:402-10 pubmed publisher
    ..ganglioside analogs with a fluorescently labeled glycosylphosphatidylinisotol (GPI)-anchored protein, human CD59, with lifetimes of 12 ms for CD59 monomers, 40 ms for CD59's transient homodimer rafts in quiescent cells, and 48 ..
  80. Viecceli D, Garcia M, Schneider L, Alegretti A, Silva C, Ribeiro A, et al. Correlation between cellular expression of complement regulatory proteins with depletion and repopulation of B-lymphocytes in peripheral blood of patients with rheumatoid arthritis treated with rituximab. Rev Bras Reumatol Engl Ed. 2017;57:385-391 pubmed publisher
    To correlate the basal expression of complement regulatory proteins (CRPs) CD55, CD59, CD35, and CD46 in B-lymphocytes from the peripheral blood of a cohort of 10 patients with rheumatoid arthritis (RA) initiating treatment with rituximab ..
  81. Nicolette J, Murray J, Sonders P, LeRoy B. A regenerative erythropoietic response does not increase the frequency of Pig-a mutant reticulocytes and erythrocytes in Sprague-Dawley rats. Environ Mol Mutagen. 2017;: pubmed publisher
    ..after exposure to potentially mutagenic chemicals for cells deficient in the cell surface anchored protein CD59, representing mutation in the X-linked Pig-a gene...
  82. Revollo J, Bhalli J, Tebbe C, Noteboom J, Thomas D, McKinzie P, et al. Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine. Mutagenesis. 2017;: pubmed publisher
    ..in order to quantify the frequencies of cells deficient in glycosylphosphatidyl inositol-anchored surface markers CD59 and CD48 (presumed mutants in the endogenous X-linked Pig-a gene) in rats...
  83. Holmes C, Simpson K, Okada H, Okada N, Wainwright S, Purcell D, et al. Complement regulatory proteins at the feto-maternal interface during human placental development: distribution of CD59 by comparison with membrane cofactor protein (CD46) and decay accelerating factor (CD55). Eur J Immunol. 1992;22:1579-85 pubmed
    ..factor (DAF, CD55) and membrane cofactor protein (MCP, CD46), which control C3 convertases, together with CD59, an inhibitor of the membrane attack complex (MAC), were found to be present in the developing human placenta from ..
  84. Lu Q, Zhang J, Allison R, Gay H, Yang W, Bhowmick N, et al. Identification of extracellular delta-catenin accumulation for prostate cancer detection. Prostate. 2009;69:411-8 pubmed publisher
    ..and co-isolated with raft-associated membrane protein caveolin-1 and glycosylphosphatidylinositol-anchored protein CD59, suggesting its potential excretion into extracellular milieu through exosome/prostasome associated pathways...
  85. Amet T, Ghabril M, Chalasani N, Byrd D, Hu N, Grantham A, et al. CD59 incorporation protects hepatitis C virus against complement-mediated destruction. Hepatology. 2012;55:354-63 pubmed publisher
    ..The current study was therefore undertaken to determine whether HCV virions incorporate biologically functional CD59, a key member of RCA...
  86. Song G, Cho W, Gu L, He B, Pan Y, Wang S. Increased CD59 protein expression is associated with the outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP. Med Oncol. 2014;31:56 pubmed publisher
    The objective was to investigate the expression and prognostic value of CD59 expression in patients with diffuse large B-cell lymphoma (DLBCL) who underwent rituximab-cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP)...
  87. Ventimiglia L, Fernández Martín L, Martínez Alonso E, Antón O, Guerra M, Martínez Menárguez J, et al. Cutting Edge: Regulation of Exosome Secretion by the Integral MAL Protein in T Cells. J Immunol. 2015;195:810-4 pubmed publisher
    ..Exosome release induced by HIV-1 Nef was also dependent on MAL expression. Therefore, MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells. ..
  88. Wang Q, Huang X, Zheng Z, Dai M, Cai W, Yang M, et al. Association of CD59 and CFH polymorphisms with acute anterior uveitis in Chinese population. Eye (Lond). 2016;30:1452-1457 pubmed publisher
    ..The present study was performed to investigate whether an association exists between CD59 and CFH genetic polymorphisms and acute anterior uveitis (AAU)...
  89. Chen J, Ding P, Li L, Gu H, Zhang X, Zhang L, et al. CD59 Regulation by SOX2 Is Required for Epithelial Cancer Stem Cells to Evade Complement Surveillance. Stem Cell Reports. 2017;8:140-151 pubmed publisher
    ..stem-like sphere-forming cells prepared from a mammary tumor and a lung adenocarcinoma cell line, we found that CD59 was upregulated to protect CSCs from complement-dependent cytotoxicity...
  90. Cui X, Zhang X, Bu H, Liu N, Li H, Guan X, et al. Shear stress-mediated changes in the expression of complement regulatory protein CD59 on human endothelial progenitor cells by ECM-integrin?V?3-F-actin pathway in vitro. Biochem Biophys Res Commun. 2017;494:416-421 pubmed publisher
    Membrane regulatory proteins, such as CD46, CD55, and CD59, prevent excess complement activation and to protect cells from damage...
  91. Cupino T, Watson B, Cupino A, Oda K, Ghamsary M, Soriano S, et al. Stability and bioactivity of chitosan as a transfection agent in primary human cell cultures: A case for chitosan-only controls. Carbohydr Polym. 2018;180:376-384 pubmed publisher
    ..We examined the impact of cell culture conditions on CsM size and the effect of chitosan on CD59 expression in primary human smooth muscle cells...
  92. Motoyama N, Okada N, Yamashina M, Okada H. Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene. Eur J Immunol. 1992;22:2669-73 pubmed
    b>HRF20 (CD59) is a membrane glycoprotein which protects cells from the membrane attack reaction of homologous complement...