Gene Symbol: CD57
Description: beta-1,3-glucuronyltransferase 1
Alias: CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, LEU7 antigen, UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase, glcUAT-P, glucuronosyltransferase P
Species: human
Products:     CD57

Top Publications

  1. Brenchley J, Karandikar N, Betts M, Ambrozak D, Hill B, Crotty L, et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood. 2003;101:2711-20 pubmed
    ..This lack of proliferative ability of HIV-specific CD8(+) T cells is defined by surface expression of CD57 but not by absence of CD28 or CCR7...
  2. Chong L, Aicheler R, Llewellyn Lacey S, Tomasec P, Brennan P, Wang E. Proliferation and interleukin 5 production by CD8hi CD57+ T cells. Eur J Immunol. 2008;38:995-1000 pubmed publisher
    CD8hi CD57+ T cells have previously been described as effector memory T cells with minimal expansion capacity and high susceptibility to activation-induced cell death...
  3. Olloquequi J, Montes J, Prats A, Rodriguez E, Montero M, García Valero J, et al. Significant increase of CD57+ cells in pulmonary lymphoid follicles of COPD patients. Eur Respir J. 2011;37:289-98 pubmed publisher
    ..of LFs, as well as the follicular density of B- and T-lymphocytes, macrophages, dendritic cells and CD57(+) cells, in lung tissue of nine nonsmokers, 18 smokers without COPD, 16 smokers with moderate COPD and 16 patients ..
  4. Dutsch Wicherek M, Lazar A, Tomaszewska R, Kazmierczak W, Wicherek L. Analysis of metallothionein and vimentin immunoreactivity in pharyngeal squamous cell carcinoma and its microenvironment. Cell Tissue Res. 2013;352:341-9 pubmed publisher
    ..The immunoreactivity levels of both MT and vimentin were evaluated together with CD56 and CD57 antigens in 49 tissue samples taken from patients with squamous cell carcinoma originating from the palatine ..
  5. Stepensky P, Rensing Ehl A, Gather R, Revel Vilk S, Fischer U, Nabhani S, et al. Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. Blood. 2015;125:753-61 pubmed publisher
    ..increased major histocompatibility complex I expression and most CD8(+) T-cells had a senescent CCR7-CD127(-)CD28(-)CD57(+) phenotype with poor proliferative responses and enhanced staurosporine-induced apoptosis...
  6. Terada T. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the ileum in a 35-year-old Japanese woman. Int J Clin Exp Pathol. 2013;6:951-6 pubmed
    ..cells were negative for T-cell markers (CD3, CD4, CD5, CD45RO, and CD43) and negative for NK cell markers (CD56 and CD57)...
  7. Wang J, Wang W, Li Y, Jin B, Yu M, Liu W, et al. A Primary Primitive Neuroectodermal Tumor Arising from Left Subclavian Vein and Extending along Left Brachiocephalic Vein and Superior Vena Cava into Right Atrium. Ann Vasc Surg. 2015;29:839.e13-20 pubmed publisher
    ..The neoplastic cells showed a strong immunopositivity for CD99, synaptophysin, CD56, CD57, and friend leukemia integration 1, thus confirming a diagnosis of the PNET...
  8. Tabata R, Tabata C, Iwama H, Yasumizu R, Kojima M. CD27-positive hairy cell leukemia-Japanese variant. Virchows Arch. 2016;468:375-9 pubmed publisher
    ..IgG, and λ but not for CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD21, CD23, CD25, CD30, CD34, CD38, CD43, CD56, CD57, CD103, IgD, IgM, and κ...
  9. Yoshizawa K, Yuki M, Kinoshita Y, Emoto Y, Yuri T, Elmore S, et al. N-methyl-N-nitrosourea-induced schwannomas in male Sprague-Dawley rats with a literature review of inducible and spontaneous lesions. Exp Toxicol Pathol. 2016;68:371-9 pubmed publisher
    ..schwannomas in male Crj:CD(SD)IGS rats including: vimentin (Vim), S100, p75 nerve growth factor receptor (LNGFR), CD57, pancytokeratin (CK), myoglobin, desmin and ? smooth muscle actin (SMA)...

More Information

Publications132 found, 100 shown here

  1. Holl E, Routh J, Johnston A, Frazier V, Rice H, Tracy E, et al. Immune expression in children with Wilms tumor: a pilot study. J Pediatr Urol. 2019;: pubmed publisher increased expression of human leukocyte antigen-DR isotype (HLA-DR), programmed cell death protein 1 (PD1), and CD57. Together, these findings suggest that WT microenvironment is immune engaged and may be susceptible to ..
  2. Vallejo A, Hamel D, Mueller R, Ives D, Michel J, Boudreau R, et al. NK-like T cells and plasma cytokines, but not anti-viral serology, define immune fingerprints of resilience and mild disability in exceptional aging. PLoS ONE. 2011;6:e26558 pubmed publisher
    ..logistic regression models, unimpaired phenotype was predicted independently by IL-5 and by CD4(+)CD28(null)CD56(+)CD57(+) T cells. All elders had high antibody titers to common viruses including cytomegalovirus...
  3. Mimura S, Suga M, Okada K, Kinehara M, Nikawa H, Furue M. Bone morphogenetic protein 4 promotes craniofacial neural crest induction from human pluripotent stem cells. Int J Dev Biol. 2016;60:21-8 pubmed publisher
    ..On the other hand, the proportion of cells expressing p75(NTR) or HNK1 decreased compared with that of cells cultured without BMP4, whereas gene expression analysis demonstrated that the ..
  4. Yi H, Kim S, Kim J, Lee Y, Moon J, Kim M, et al. T-cell senescence contributes to abnormal glucose homeostasis in humans and mice. Cell Death Dis. 2019;10:249 pubmed publisher
    ..Human senescent (CD28-CD57+) CD8+ T cells are increased in the development of diabetes and proinflammatory cytokines and ..
  5. Domingo Musibay E, Murugan P, Giubellino A, Sharma S, Steinberger D, Yuan J, et al. Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma. J Immunother Cancer. 2018;6:58 pubmed publisher
    ..with circulating CD8+ T cells with central memory (CM) and effector memory (EM) phenotype and mature CD16?+?CD57+ NK cells...
  6. Parra E, Villalobos P, Behrens C, Jiang M, Pataer A, Swisher S, et al. Effect of neoadjuvant chemotherapy on the immune microenvironment in non-small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches. J Immunother Cancer. 2018;6:48 pubmed publisher
    ..1 included AE1/AE3, PD-L1, CD3, CD4, CD8, and CD68; panel 2 included AE1/AE3, PD1, granzyme B, FOXP3, CD45RO, and CD57. PD-L1 expression was higher (> overall median) in NCT cases (median, 19.53%) than in non-NCT cases (median, 1...
  7. Grome H, Barnett L, Hagar C, Harrison D, Kalams S, Koethe J. Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV. AIDS Res Hum Retroviruses. 2017;33:181-186 pubmed publisher
    ..activated (CD38+ and CD38+DR+), exhausted (PD1+), senescent (CD57+), and memory (CD45RO+) CD4+ and CD8+ T cell subsets by flow cytometry, ..
  8. Hutten T, Norde W, Woestenenk R, Wang R, Maas F, Kester M, et al. Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8+ T Cells During Relapse after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2018;24:666-677 pubmed publisher
    ..T cells exhibited an early differentiated CD27++/CD28++ phenotype with low KLRG-1 and CD57 expression...
  9. Merli P, Caruana I, De Vito R, Strocchio L, Weber G, Del Bufalo F, et al. Role of IFNγ in immune-mediated graft failure occurring after allogeneic hematopoietic stem cell transplantation. Haematologica. 2019;: pubmed publisher
    ..cells, which showed markers of activation (over-expression of CD95 and down-regulation of CD127) and exhaustion (CD57, CD279, CD223 and CD366)...
  10. Kefalakes H, Koh C, Sidney J, Amanakis G, Sette A, Heller T, et al. Hepatitis D Virus-Specific CD8+ T Cells Have a Memory-Like Phenotype Associated With Viral Immune Escape in Patients With Chronic Hepatitis D Virus Infection. Gastroenterology. 2019;156:1805-1819.e9 pubmed publisher
    ..HDV-specific CD8+ T cells did not express the terminal differentiation marker CD57, and fewer HDV-specific than Epstein-Barr virus-specific CD8+ T cells were 2B4+CD160+
  11. Banerjee P, Dutta S, Pal R. Dysregulation of Wnt-Signaling and a Candidate Set of miRNAs Underlie the Effect of Metformin on Neural Crest Cell Development. Stem Cells. 2016;34:334-45 pubmed publisher
  12. Li W, Huang L, Lin W, Ke Q, Chen R, Lai X, et al. Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells. Biomaterials. 2015;39:75-84 pubmed publisher
    ..substrate and showed characteristic expression of NCSC markers, including Sox10, AP2α, Slug, Nestin, p75, and HNK1. CmNCSCs were capable of propagating in an undifferentiated state in vitro as adherent or suspension cultures, ..
  13. Clausen T, Pereira M, Al Nakouzi N, Oo H, Agerbæk M, Lee S, et al. Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility. Mol Cancer Res. 2016;14:1288-1299 pubmed
    ..The cancer-specific expression of ofCS aids in metastatic phenotypes and is a candidate target for therapy. Mol Cancer Res; 14(12); 1288-99. ©2016 AACR. ..
  14. Gadalla S, Aubert G, Wang T, Haagenson M, Spellman S, Wang L, et al. Donor Telomere Length and Causes of Death after Unrelated Hematopoietic Cell Transplant in Patients with Marrow Failure. Blood. 2018;: pubmed publisher
    ..enriched T-cells (CD45RA+CD20-), memory enriched T-cells (CD45RA-CD20-), NK-fully differentiated T cells (CD45RA+CD57+), and B cells (CD45RA+CD20+). Competing risks survival regression was used for cause-specific death analyses...
  15. ManfrereC K, Torrealba M, Miyashiro D, Pereira N, Yoshikawa F, de M Oliveira L, et al. Profile of differentially expressed Toll-like receptor signaling genes in the natural killer cells of patients with Sézary syndrome. Oncotarget. 2017;8:92183-92194 pubmed publisher
    ..In contrast, an expansion of "memory" CD57+ NKG2C+ NK cells and high cytomegalovirus antibody titers were detected in SS patients...
  16. Zhang P, Wang G, Lin Z, Wu Y, Zhang J, Liu M, et al. Alcohol exposure induces chick craniofacial bone defects by negatively affecting cranial neural crest development. Toxicol Lett. 2017;281:53-64 pubmed publisher
    ..In addition, ethanol affected the delamination, epithelial-mesenchymal transition (EMT) and cell migration of cranial NCCs, which may have contributed to the etiology of the craniofacial defects. ..
  17. Weber B, Schlapbach C, Stuck M, Simon H, Borradori L, Beltraminelli H, et al. Distinct interferon-gamma and interleukin-9 expression in cutaneous and oral lichen planus. J Eur Acad Dermatol Venereol. 2017;31:880-886 pubmed publisher
    ..staining and laser scanning microscopy, we evaluated the cellular infiltrate (CD1a, CD3, CD4, CD8, CD21, CD57, CD123), cytokine expression (interleukin (IL)-1, IL-6, IL-9, IL-10, IL-17, IL-22, IL-23, tumour necrosis factor-Î..
  18. Moalem J, Choi D, Khanafshar E, Ruan D, Woeber K, Clark O, et al. Metastatic papillary thyroid cancer misdiagnosed as non-small [corrected] cell lung cancer. Thyroid. 2011;21:319-23 pubmed publisher
    ..of the immunohistological characteristics of both surgical specimens--including staining for TTF-1, thyroglobulin, CD57, S-100, and CEA--documented the correct diagnosis...
  19. Crough T, Beagley L, Smith C, Jones L, Walker D, Khanna R. Ex vivo functional analysis, expansion and adoptive transfer of cytomegalovirus-specific T-cells in patients with glioblastoma multiforme. Immunol Cell Biol. 2012;90:872-80 pubmed publisher
    ..of CD8(+) T-cells and a high proportion of these cells were positive for the human natural killer-1 glycoprotein CD57. Furthermore, ex vivo polychromatic functional analysis of the CMV-specific T-cells from GBM patients revealed that ..
  20. Cordeiro I, Lopes D, Abreu J, Carneiro K, Rossi M, Brito J. Chick embryo xenograft model reveals a novel perineural niche for human adipose-derived stromal cells. Biol Open. 2015;4:1180-93 pubmed publisher
    ..Surprisingly, 82.5% of the hADSC were associated with HNK1+ tissues, such as peripheral nerves. Human skin fibroblasts showed a smaller tropism for nerves...
  21. Truschnegg A, Acham S, Kqiku L, Jakse N, Beham A. Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report. Int J Oral Sci. 2018;10:4 pubmed publisher
    ..showed the majority of cases to be positive for glial fibrillary acidic protein (GFAP), S-100 protein, glycoprotein CD57, pancytokeratin (AE1/AE3), and smooth muscle actin (SMA); in isolated cases there was molecular-genetic ..
  22. Mazzaschi G, Madeddu D, Falco A, Bocchialini G, Goldoni M, Sogni F, et al. Low PD-1 Expression in Cytotoxic CD8+ Tumor-Infiltrating Lymphocytes Confers an Immune-Privileged Tissue Microenvironment in NSCLC with a Prognostic and Predictive Value. Clin Cancer Res. 2018;24:407-419 pubmed publisher
    ..PD-L1 expression and the incidence of CD3, CD8, CD4, PD-1, CD57, FOXP3, CD25, and Granzyme B TILs were immunohistochemically assessed...
  23. Fachin L, Soares C, Belone A, Trombone A, Rosa P, Guidella C, et al. Immunohistochemical assessment of cell populations in leprosy-spectrum lesions and reactional forms. Histol Histopathol. 2017;32:385-396 pubmed publisher
    ..and quantitative immunohistochemical analyses were performed to detect CD3, CD4, CD8, FoxP3, CD20, CD138, CD1a, CD57, CD15, CD117, CD68, and CD163. In addition, histochemistry was employed to identify eosinophils...
  24. Scheffel M, Scurti G, Wyatt M, Garrett Mayer E, Paulos C, Nishimura M, et al. N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner. Cancer Immunol Immunother. 2018;67:691-702 pubmed publisher
    ..Interestingly, NAC did not affect memory subsets, but diminished up-regulation of senescence (CD57) and exhaustion (PD-1) markers and significantly decreased expression of the transcription factors EOMES and Foxo1...
  25. Mohme M, Schliffke S, Maire C, Rünger A, Glau L, Mende K, et al. Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes. Clin Cancer Res. 2018;24:4187-4200 pubmed publisher
    ..marker expression, and exhibition of an effector-/transitional memory differentiation phenotype, whereas KLRG1 and CD57 were underrepresented...
  26. Graff R, Kunz H, Agha N, Baker F, Laughlin M, Bigley A, et al. β2-Adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans. Brain Behav Immun. 2018;74:143-153 pubmed publisher
    ..The mobilization of total NK-cells, terminally differentiated (CD57+) NK-cells, central memory, effector memory and CD45RA+ effector memory CD8+ T-cells; non-classical monocytes; and ..
  27. Basa R, Davies V, Li X, Murali B, Shah J, Yang B, et al. Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans. PLoS ONE. 2016;11:e0156660 pubmed publisher
    ..No significant differences were observed in CD8+ (p = 0.83), CD57+ (p = 0.55), and IL-17-expressing (p = 0.63) cell numbers within the tumor samples tested...
  28. Frenzen F, Roder C, Wollschläger B, Großer E, Krohe K, Schmidt B. [Pichia guilliermondii Infection - A Rare Differential Diagnosis of Pulmonary Nodules]. Pneumologie. 2016;70:605-7 pubmed publisher
    ..The bronchoscopy was macroscopically normal. In the BAL yeasts and a high proportion of immune senescence cells (CD57+) were identified...
  29. Wallet M, Buford T, Joseph A, Sankuratri M, Leeuwenburgh C, Pahor M, et al. Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects. BMC Immunol. 2015;16:43 pubmed publisher
    ..003) and an increased frequency of CD4(+) and CD8(+) T cells with an immunosenescent CD57(+) phenotype (P = 0.004 and P = 0.043, respectively)...
  30. Bottomley M, Harden P, Wood K. CD8+ Immunosenescence Predicts Post-Transplant Cutaneous Squamous Cell Carcinoma in High-Risk Patients. J Am Soc Nephrol. 2016;27:1505-15 pubmed publisher
    ..The percentage of CD57-expressing CD8(+) T cells was the strongest immunologic predictor of future SCC and correlated with increasing CD8(+..
  31. Rao V, Webster S, Dalm V, Sediva A, van Hagen P, Holland S, et al. Effective "activated PI3K? syndrome"-targeted therapy with the PI3K? inhibitor leniolisib. Blood. 2017;130:2307-2316 pubmed publisher
    ..of circulating transitional and naive B cells, reduction in PD-1+CD4+ and senescent CD57+CD4- T cells, and decreases in elevated serum immunoglobulin M and inflammatory markers ..
  32. Baychelier F, Achour A, Nguyen S, Raphael M, Toubert A, Besson C, et al. Natural killer cell deficiency in patients with non-Hodgkin lymphoma after lung transplantation. J Heart Lung Transplant. 2015;34:604-12 pubmed publisher
    ..overexpression of NKG2A and CD62L and down-modulation of inhibitory killer immunoglobulin-like receptors and CD57 receptors...
  33. Thobakgale C, Fadda L, Lane K, Toth I, Pereyra F, Bazner S, et al. Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection. J Virol. 2012;86:6986-93 pubmed publisher
    ..Further studies are needed to assess the consequences of these antibody-mediated NK cell responses for HIV-1 disease progression and vaccine-induced protection from infection. ..
  34. Rollo B, Zhang D, Simkin J, Menheniott T, Newgreen D. Why are enteric ganglia so small? Role of differential adhesion of enteric neurons and enteric neural crest cells. F1000Res. 2015;4:113 pubmed publisher
  35. Ma Z, Hu J. Production and characterization of surfactin-type lipopeptides as bioemulsifiers produced by a Pinctada martensii-derived Bacillus mojavensis B0621A. Appl Biochem Biotechnol. 2015;177:1520-9 pubmed publisher
    ..fatty acid chain residue (from C13 to C15), differed each other from peptide sequence in the position of Leu7 or Val7. All these surfactins had significant activity and stability of emulsification under various pH (from 7...
  36. Jensen S, Tingstedt J, Larsen T, Brandt L, Gerstoft J, Kronborg G, et al. HIV-Specific CD8+ T Cell-Mediated Viral Suppression Correlates With the Expression of CD57. J Acquir Immune Defic Syndr. 2016;71:8-16 pubmed publisher
    ..The phenotypic profile of CD8(+) T cells was determined by whole blood staining. The expression of CD57 on effector CD8(+) T cells correlated with the suppression of HIV-1 replication and to the duration of ART...
  37. Juárez Vega G, Rangel Ramírez V, Monsiváis Urenda A, Niño Moreno P, García Sepúlveda C, Noyola D, et al. Comparative analysis of NK cell receptor repertoire in adults and very elderly subjects with cytomegalovirus infection. Hum Immunol. 2017;78:274-280 pubmed publisher
    ..A significant increase in the levels of CD3-CD56+NKG2C+CD57+ cells was also detected in the elderly groups...
  38. Kaczmarek D, Kokordelis P, Kramer B, Glässner A, Wolter F, Goeser F, et al. Alterations of the NK cell pool in HIV/HCV co-infection. PLoS ONE. 2017;12:e0174465 pubmed publisher
    ..decreased expression of the maturation/differentiation markers CD27/62L/127 on NK cells but increased expression of CD57 compared to healthy controls...
  39. Dobrovolskienė N, Cicėnas S, Kazlauskaitė N, Mišeikytė Kaubrienė E, Krasko J, Ostapenko V, et al. CD8(high)CD57(+) T-cell population as an independent predictor of response to chemoradiation therapy in extensive-stage small cell lung cancer. Lung Cancer. 2015;90:326-33 pubmed publisher
    ..Using multicolor flow cytometry, we evaluated a predictive value of CD8(high)CD57(+) T-cell population and its immunosuppressive (FOXP3(+), NKG2A(+)) and cytotoxic (Perforin(+)) subsets in the ..
  40. Darboe A, Danso E, Clarke E, Umesi A, Touray E, Wegmüller R, et al. Enhancement of cytokine-driven NK cell IFN-γ production after vaccination of HCMV infected Africans. Eur J Immunol. 2017;47:1040-1050 pubmed publisher
    ..NK cells, with increased frequencies of IFN-γ+ cells observed within CD56bright CD57- , CD56dim CD57- NKG2C- and CD56dim CD57- NKG2C<..
  41. Cata J, Ramirez M, Velásquez J, Di A, Popat K, Gottumukkala V, et al. Lidocaine Stimulates the Function of Natural Killer Cells in Different Experimental Settings. Anticancer Res. 2017;37:4727-4732 pubmed
    ..on the expression of galactosylgalactosylxylosylprotein3-beta-glucuronosytranferase 1, marker of cell maturation (CD57), killer cell lectin like receptor A, inhibitory (NKG2A) receptors and killer cell lectin like receptor D, ..
  42. Keawvichit R, Khowawisetsut L, Lertjuthaporn S, Tangnararatchakit K, Apiwattanakul N, Yoksan S, et al. Differences in activation and tissue homing markers of natural killer cell subsets during acute dengue infection. Immunology. 2017;: pubmed publisher
    ..The activation/differentiation molecules, CD69 and CD57 and a variety of tissue homing molecules were analyzed on the CD56hi CD16- and CD56lo
  43. Aiello A, Dowd J, Jayabalasingham B, Feinstein L, Uddin M, Simanek A, et al. PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit. Psychoneuroendocrinology. 2016;67:133-41 pubmed publisher naïve (CCR7+CD45RA+CD27+CD28+) T cells, the percentage of KLRG1-expressing cells, and the percentage of CD57-expressing cells...
  44. Kelesidis T, Jackson N, McComsey G, Wang X, Elashoff D, Dube M, et al. Oxidized lipoproteins are associated with markers of inflammation and immune activation in HIV-1 infection. AIDS. 2016;30:2625-2633 pubmed
    ..sCD14, soluble IL-2 receptor, CD38 and HLA-DR), inflammatory monocytes (CD14CD16), T-cell senescence (CD28 and CD57) and exhaustion (PD1), and HDLox, LDLox were assessed at entry and after ART (week 96) with Spearman (partial) ..
  45. Streltsova M, Barsov E, Erokhina S, Kovalenko E. Retroviral gene transfer into primary human NK cells activated by IL-2 and K562 feeder cells expressing membrane-bound IL-21. J Immunol Methods. 2017;450:90-94 pubmed publisher
    ..More mature CD57+ NK cell population was generally resistant to retroviral vector transduction because of poor response ..
  46. Clénet M, Gagnon F, Moratalla A, Viel E, Arbour N. Peripheral human CD4+CD8+ T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15. Sci Rep. 2017;7:11612 pubmed publisher
    ..g. CCR7, CXCR3, CCR6) and activation markers (e.g. CD57, CD95)...
  47. Yabuno K, Morise J, Kizuka Y, Hashii N, Kawasaki N, Takahashi S, et al. A Sulfated Glycosaminoglycan Linkage Region is a Novel Type of Human Natural Killer-1 (HNK-1) Epitope Expressed on Aggrecan in Perineuronal Nets. PLoS ONE. 2015;10:e0144560 pubmed publisher
    ..These results could lead to discovery of new roles of the HNK-1 epitope in neural plasticity. ..
  48. Breloy I, Schwientek T, Althoff D, Holz M, Koppen T, Krupa A, et al. Functional Analysis of the Glucuronyltransferases GlcAT-P and GlcAT-S of Drosophila melanogaster: Distinct Activities towards the O-linked T-antigen. Biomolecules. 2016;6:8 pubmed publisher able to use N-linked N-acetyllactosamine chains and the O-linked T-antigen as a substrate to form non-sulfated HNK1- (GlcAβ1-3Galβ1-4GlcNAcβ1-) and glucuronyl-T-antigens in vivo, GlcAT-S adds glucuronic acid only to N-..
  49. Peery A, Keku T, Addamo C, McCoy A, Martin C, Galanko J, et al. Colonic Diverticula Are Not Associated With Mucosal Inflammation or Chronic Gastrointestinal Symptoms. Clin Gastroenterol Hepatol. 2018;16:884-891.e1 pubmed publisher
    ..RNAs by quantitative reverse-transcriptase polymerase chain reaction, and numbers of immune cells (CD4+, CD8+, CD57+, and mast cell tryptase) by immunohistochemistry. Gastrointestinal symptoms were assessed using Rome III criteria...
  50. Tchaou M, Darre T, Folligan K, Sabi A, Sonhaye L, Boume A, et al. Primary Neuroendocrine Breast Carcinoma in a 13-Year-Old Girl: Ultrasonography and Pathology Findings. Case Rep Radiol. 2017;2017:7915806 pubmed publisher
    ..According to immunohistochemistry performed on paraffin blocks in France, infiltrating ductal carcinoma with a strong neuroendocrine component was confirmed by CD56, CD57, and chromogranin A markers.
  51. Najima Y, Yoshida C, Iriyama N, Fujisawa S, Wakita H, Chiba S, et al. Regulatory T cell inhibition by dasatinib is associated with natural killer cell differentiation and a favorable molecular response-The final results of the D-first study. Leuk Res. 2018;66:66-72 pubmed publisher
    ..Furthermore, the degree of NK cell differentiation (CD3-CD57+/CD3-CD56+) was closely and inversely correlated with the proportion of Treg cells ..
  52. Liu K, Yang K, Wu B, Chen H, Chen X, Chen X, et al. Tumor-Infiltrating Immune Cells Are Associated With Prognosis of Gastric Cancer. Medicine (Baltimore). 2015;94:e1631 pubmed publisher
    ..S), and adjacent normal tissue (N) of 166 gastric cancer cases and their interactions, including CD3+, CD4+, CD8, CD57+, CD68+, CD66b+, and Foxp3+ cells, and established an effective prognostic nomogram based on the immune reactions...
  53. Heath J, Newhook N, Comeau E, Gallant M, Fudge N, Grant M. NKG2C(+)CD57(+) Natural Killer Cell Expansion Parallels Cytomegalovirus-Specific CD8(+) T Cell Evolution towards Senescence. J Immunol Res. 2016;2016:7470124 pubmed publisher
    Objective. Measuring NKG2C(+)CD57(+) natural killer (NK) cell expansion to investigate NK responses against human cytomegalovirus (HCMV) and assessing relationships with adaptive immunity against HCMV. Methods...
  54. de Araújo M, Etchebehere R, de Melo M, Beghini M, Severino V, de Castro Côbo E, et al. Analysis of CD15, CD57 and HIF-1? in biopsies of patients with peri-implantitis. Pathol Res Pract. 2017;213:1097-1101 pubmed publisher
    ..The aim of the present cross-sectional study was to evaluate histological changes and immunostaining for CD15, CD57 and HIF-1? in the peri-implant mucosa of patients with and without peri-implantitis...
  55. Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T. Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope. Genomics. 2000;65:166-73 pubmed
    ..Northern blot analysis indicated that human GlcAT-P is expressed mainly in the brain. There is a single copy of the human GlcAT-P gene (HGMW-approved symbol B3GAT1), and it was mapped to chromosome 11q25. ..
  56. Ibegbu C, Xu Y, Harris W, Maggio D, Miller J, Kourtis A. Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57. J Immunol. 2005;174:6088-94 pubmed
    ..We further observed that CD8(+) cells expressing CD57, a marker of replicative senescence, also expressed KLRG1; however, a population of CD57(-)KLRG1(+) cells was also ..
  57. Hartmann E, Rudelius M, Burger J, Rosenwald A. CCL3 chemokine expression by chronic lymphocytic leukemia cells orchestrates the composition of the microenvironment in lymph node infiltrates. Leuk Lymphoma. 2016;57:563-71 pubmed publisher
    ..Significantly higher numbers of CD3+ T cells and CD57+ cells were noticed in CCL3 positive cases...
  58. Peppa D. Natural Killer Cells in Human Immunodeficiency Virus-1 Infection: Spotlight on the Impact of Human Cytomegalovirus. Front Immunol. 2017;8:1322 pubmed publisher
    ..NK-cell subsets, predominately expressing the activating receptor NKG2C and the marker of terminal differentiation CD57, expand in response to HCMV...
  59. Siniscalco D, Mijatovic T, Bosmans E, Cirillo A, Kruzliak P, Lombardi V, et al. Decreased Numbers of CD57+CD3- Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder. In Vivo. 2016;30:83-9 pubmed
    ..The aim of this study was to evaluate the CD57(+)CD3(-) mature lymphocyte subpopulation of natural killer cells as a marker of immune dysfunction in ASD...
  60. Zhang X, Sokol L, Bennett J, Moscinski L, List A, Zhang L. T-cell large granular lymphocyte proliferation in myelodysplastic syndromes: Clinicopathological features and prognostic significance. Leuk Res. 2016;43:18-23 pubmed publisher
    ..The peripheral blood CD3+/CD57+ cell counts were significantly different (p<0.01) between the two groups...
  61. Yang R, Xu X. Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles. Methods Mol Biol. 2016;1453:49-55 pubmed publisher
    ..we present a protocol to isolate NCSCs from human hair follicles based on their specific surface-marker expression of CD271/HNK1 or CD271/CD49D (alpha4 integrin). NCSCs can be expanded in the culture as neural spheres or attached cells.
  62. Rölle A, Halenius A, Ewen E, Cerwenka A, Hengel H, Momburg F. CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection. Eur J Immunol. 2016;46:2420-2425 pubmed publisher
    ..Phenotypically, a majority of adaptive NK cells expresses the activating receptor NKG2C and CD57. Some of the molecular factors driving the expansion of NKG2C+ CD57+ NK cells in HCMV ..
  63. Herrendorff R, Hänggi P, Pfister H, Yang F, Demeestere D, Hunziker F, et al. Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy. Proc Natl Acad Sci U S A. 2017;114:E3689-E3698 pubmed publisher
    ..The observed efficient removal of these antibodies with the glycopolymer PL84(mimHNK-1)45 represents an important step toward an antigen-specific therapy for anti-MAG neuropathy. ..
  64. Hassouneh F, Campos C, López Sejas N, Alonso C, Tarazona R, Solana R, et al. Effect of age and latent CMV infection on CD8+ CD56+ T cells (NKT-like) frequency and functionality. Mech Ageing Dev. 2016;158:38-45 pubmed publisher
    ..NKT-like cells expressing CD57 are expanded in CMV-seropositive individuals and are more polyfunctional than their CD57-  counterpart...
  65. Li Y, Wei J, Mao X, Gao Q, Liu L, Cheng P, et al. Flow Cytometric Immunophenotyping Is Sensitive for the Early Diagnosis of De Novo Aggressive Natural Killer Cell Leukemia (ANKL): A Multicenter Retrospective Analysis. PLoS ONE. 2016;11:e0158827 pubmed publisher
    ..were found to have a distinctiveCD56bright/CD16dim immunophenotype and markedly increased Ki-67 expression, whereas CD57 negativity and reduced expression of killer immunoglobulin-like receptor (KIR), CD161, CD7, CD8 and perforin were ..
  66. Pera A, Vasudev A, Tan C, Kared H, Solana R, Larbi A. CMV induces expansion of highly polyfunctional CD4+ T cell subset coexpressing CD57 and CD154. J Leukoc Biol. 2017;101:555-566 pubmed publisher
    ..degranulation (CD107a), and cytokine production (IFN-?, TNF-?, and IL-2) as well as T cell phenotype markers (CD57, CD28, and CD27) were analyzed...
  67. Newhook N, Fudge N, Grant M. NK cells generate memory-type responses to human cytomegalovirus-infected fibroblasts. Eur J Immunol. 2017;47:1032-1039 pubmed publisher
    ..Human cytomegalovirus (HCMV) infection causes expansion of NKG2C+ CD57+ NK cells in vivo and NKG2C+ NK cells proliferate when cultured with HCMV-infected cells...
  68. Pedersen L, Tsuchida K, Kitagawa H, Sugahara K, Darden T, Negishi M. Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I. J Biol Chem. 2000;275:34580-5 pubmed
    ..The key residues involved in substrate binding and catalysis are conserved in the glucuronyltransferase family as well as other glycosyltransferases. ..
  69. Barre L, Venkatesan N, Magdalou J, Netter P, Fournel Gigleux S, Ouzzine M. Evidence of calcium-dependent pathway in the regulation of human beta1,3-glucuronosyltransferase-1 (GlcAT-I) gene expression: a key enzyme in proteoglycan synthesis. FASEB J. 2006;20:1692-4 pubmed
    ..The present study identifies, for the first time, GlcAT-I as a target of calcium-dependent signaling pathway and evidences the critical role of Sp1 transcription factor in the activation of GlcAT-I expression. ..
  70. Tanaskovic S, Price P, French M, Fernandez S. Impaired Upregulation of the Costimulatory Molecules, CD27 and CD28, on CD4+ T Cells from HIV Patients Receiving ART Is Associated with Poor Proliferative Responses. AIDS Res Hum Retroviruses. 2017;33:101-109 pubmed publisher
    ..Results were related to proportions of CD4+ T cells expressing markers of T cell senescence (CD57), activation (HLA-DR), and apoptotic potential (Fas)...
  71. Maydych V, Claus M, Dychus N, Ebel M, Damaschke J, Diestel S, et al. Impact of chronic and acute academic stress on lymphocyte subsets and monocyte function. PLoS ONE. 2017;12:e0188108 pubmed publisher an indication of chronic stress, moderated the relationships between academic stress and percentages of mature CD57+ NK cells...
  72. Petrovas C, Chaon B, Ambrozak D, Price D, Melenhorst J, Hill B, et al. Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection. J Immunol. 2009;183:1120-32 pubmed publisher
    ..Expression of PD-1 and CD57 was differentially associated with the maturation status of CD8(+) T cells in HIV infection...
  73. Björkström N, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson M, et al. Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education. Blood. 2010;116:3853-64 pubmed publisher
    ..lose expression of NKG2A, sequentially acquire inhibitory killer cell inhibitory immunoglobulin-like receptors and CD57, change their expression patterns of homing molecules, and display a gradual decline in proliferative capacity...
  74. Seu L, Tidwell C, Timares L, Duverger A, Wagner F, Goepfert P, et al. CD151 Expression Is Associated with a Hyperproliferative T Cell Phenotype. J Immunol. 2017;199:3336-3347 pubmed publisher
    ..CD151 and CD57, a senescence marker, defined the same CD28- T cell populations...
  75. Kakuda S, Shiba T, Ishiguro M, Tagawa H, Oka S, Kajihara Y, et al. Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1. J Biol Chem. 2004;279:22693-703 pubmed
    ..These three residues play a key role in establishing the acceptor substrate specificity. ..
  76. Schlitter A, Dorneburg C, Barth T, Wahl J, Schulte J, Brüderlein S, et al. CD57(high) neuroblastoma cells have aggressive attributes ex situ and an undifferentiated phenotype in patients. PLoS ONE. 2012;7:e42025 pubmed publisher
    Neuroblastoma is thought to originate from neural crest-derived cells. CD57 defines migratory neural crest cells in normal development and is expressed in neuroblastoma...
  77. Zhu X, Prasad S, Gaedicke S, Hettich M, Firat E, Niedermann G. Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57. Oncotarget. 2015;6:171-84 pubmed
    ..Direct contact with patient-derived GBM-SCs caused rapid upregulation of CD57 on the CAR T cells, a molecule known to mark terminally or near-terminally differentiated T cells...
  78. Marras F, Casabianca A, Bozzano F, Ascierto M, Orlandi C, Di Biagio A, et al. Control of the HIV-1 DNA Reservoir Is Associated In Vivo and In Vitro with NKp46/NKp30 (CD335 CD337) Inducibility and Interferon Gamma Production by Transcriptionally Unique NK Cells. J Virol. 2017;91: pubmed publisher
    ..Adaptive (NKG2C+ CD57+) NK cell features were not associated with reservoir size...
  79. Elwenspoek M, Sias K, Hengesch X, Schaan V, Leenen F, Adams P, et al. T Cell Immunosenescence after Early Life Adversity: Association with Cytomegalovirus Infection. Front Immunol. 2017;8:1263 pubmed publisher
    ..However, when specifically investigating T cells, we found a higher expression of senescence markers (CD57) in ELA...
  80. Casado J, Delgado E, Patsavoudi E, Duran E, Sanchez Correa B, Morgado S, et al. Functional implications of HNK-1 expression on invasive behaviour of melanoma cells. Tumour Biol. 2008;29:304-10 pubmed publisher
    HNK-1 epitope, also known as CD57, is expressed on a wide range of cells and has been related to cell to cell and cell to extracellular matrix interactions...
  81. Hendricks D, Balfour H, Dunmire S, Schmeling D, Hogquist K, Lanier L. Cutting edge: NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus. J Immunol. 2014;192:4492-6 pubmed publisher
    ..NK cells in the blood and, in CMV(+) individuals, induced an increased frequency of mature CD56(dim)NKG2A(+)CD57(+) NK cells in the blood that persisted into latency...
  82. Nerreter T, Zeiß S, Herrmann T, Einsele H, Seggewiss Bernhardt R. Robust 8-color flow cytometry panel reveals enhanced effector function of NKG2C+ CD57+ Fc?R?- NK cells in CMV seropositive human blood donors. Immunobiology. 2017;222:719-725 pubmed publisher
    ..that allows quantification and functional analysis of different memory-like NK cell subsets (NKG2C+/CD57+, Fc?R?-) from relatively small blood samples...
  83. Sakuda K, Kizuka Y, Yamaguchi Y, Tanaka K, Ogiwara K, Segawa T, et al. Reactivity of anti-HNK-1 antibodies to branched O-mannose glycans associated with demyelination. Biochem Biophys Res Commun. 2017;487:450-456 pubmed publisher
    ..Finally, we confirmed the increased HNK-1 epitope expression in demyelinated brains of cuprizone-fed mice. ..
  84. Cencioni M, Magliozzi R, Nicholas R, Ali R, Malik O, Reynolds R, et al. Programmed death 1 is highly expressed on CD8+ CD57+ T cells in patients with stable multiple sclerosis and inhibits their cytotoxic response to Epstein-Barr virus. Immunology. 2017;152:660-676 pubmed publisher
    ..We demonstrate that polyfunctional cytotoxic CD8+ CD57+ T cells are able to kill EBV-infected cells in healthy donors...
  85. Cichocki F, Valamehr B, Bjordahl R, Zhang B, Rezner B, Rogers P, et al. GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity. Cancer Res. 2017;77:5664-5675 pubmed publisher
    Maturation of human natural killer (NK) cells as defined by accumulation of cell-surface expression of CD57 is associated with increased cytotoxic character and TNF and IFNγ production upon target-cell recognition...
  86. Hashimoto H, Sterk M, Schilbach K. CD28neg. T lymphocytes of a melanoma patient harbor tumor immunity and a high frequency of germline-encoded and public TCRs. Immunol Res. 2018;66:79-86 pubmed publisher
    ..While over 80% of his CD8+CD28neg. T cells expressed a cytotoxicity marker, CD57, only 0.01% of CD8+ CD28neg. T cells were positive for Foxp3...
  87. Mojumdar K, Vajpayee M, Chauhan N, Singh A, Singh R, Kurapati S. Loss of CD127 & increased immunosenescence of T cell subsets in HIV infected individuals. Indian J Med Res. 2011;134:972-81 pubmed publisher
    ..leads to change in T cell survival and regenerative capacity, as suggested by differential expression of CD127 and CD57. We evaluated the expression patterns of CD127 and CD57 on CD4 and CD8 effector, memory and naïve T cell subsets ..
  88. Jansen M, van Den Heuvel D, Jaddoe V, van Zelm M, Moll H. Abnormalities in CD57+ cytotoxic T cells and V?1+ ??T cells in subclinical celiac disease in childhood are affected by cytomegalovirus. The Generation R Study. Clin Immunol. 2017;183:233-239 pubmed publisher
    ..We here studied whether subclinical CD is associated with changes in blood CD57-expressing and V?1-expressing lymphocytes in children, and whether cytomegalovirus (CMV) infection modifies this ..
  89. Zhu Q, Li M, Yan C, Lu Q, Wei S, Gao R, et al. Directed Differentiation of Human Embryonic Stem Cells to Neural Crest Stem Cells, Functional Peripheral Neurons, and Corneal Keratocytes. Biotechnol J. 2017;12: pubmed publisher
    ..In the feeder-free system, hESC-derived NCSCs (P75+ /HNK1+ /AP2?+ /PAX6- ) in high purity are efficiently generated following ..
  90. Zhang H, Huang Z, Wu X, Li Q, Yu Z. Comparison of T lymphocyte subsets in aplastic anemia and hypoplastic myelodysplastic syndromes. Life Sci. 2017;189:71-75 pubmed publisher
    ..proportions of peripheral blood T lymphocyte subsets, CD3-CD16/CD56+NK cells, CD3+CD57+T-LGL cells and CD19+B lymphocytes were detected by flow cytometry...
  91. Jagannathan P, Lutwama F, Boyle M, Nankya F, Farrington L, McIntyre T, et al. Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. Sci Rep. 2017;7:11487 pubmed publisher
    ..Microscopic parasitemia and expression of the immunoregulatory markers Tim-3 and CD57 were associated with diminished Vδ2+ T cell pro-inflammatory cytokine production...
  92. Espinoza J, Takami A, Onizuka M, Sao H, Akiyama H, Miyamura K, et al. NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies. Haematologica. 2009;94:1427-34 pubmed publisher
    ..In patients with standard-risk disease, the donor NKG2D-HNK1 haplotype, a haplotype expected to induce greater natural killer cell activity, was associated with significantly ..