CD56

Summary

Gene Symbol: CD56
Description: neural cell adhesion molecule 1
Alias: CD56, MSK39, NCAM, neural cell adhesion molecule 1, antigen recognized by monoclonal antibody 5.1H11, neural cell adhesion molecule, NCAM
Species: human
Products:     CD56

Top Publications

  1. Huerta S, Srivatsan E, Venkatesan N, Peters J, Moatamed F, Renner S, et al. Alternative mRNA splicing in colon cancer causes loss of expression of neural cell adhesion molecule. Surgery. 2001;130:834-43 pubmed
    The neural cell adhesion molecule (NCAM) has numerous isoforms resulting from alternative splicing of mRNA...
  2. Arellano J, DeFelipe J, Munoz A. PSA-NCAM immunoreactivity in chandelier cell axon terminals of the human temporal cortex. Cereb Cortex. 2002;12:617-24 pubmed
    In the adult central nervous system, the expression of polysialylated forms of the cell-surface glycoprotein NCAM (PSA-NCAM) is thought to be confined to areas particularly susceptible to plastic changes...
  3. Mendiratta S, Sekulic N, Hernandez Guzman F, Close B, Lavie A, Colley K. A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylation. J Biol Chem. 2006;281:36052-9 pubmed
    ..acid is a developmentally regulated, anti-adhesive glycan that is added to the neural cell adhesion molecule, NCAM. Polysialylated NCAM is critical for brain development and plays roles in synaptic plasticity, axon guidance, and ..
  4. Nechifor Boila A, Cătană R, Loghin A, Radu T, Borda A. Diagnostic value of HBME-1, CD56, Galectin-3 and Cytokeratin-19 in papillary thyroid carcinomas and thyroid tumors of uncertain malignant potential. Rom J Morphol Embryol. 2014;55:49-56 pubmed
    We aimed to evaluate four immunohistochemical markers (HBME-1, Galectin-3, Cytokeratin-19 and CD56) used alone or in panels in a series of papillary thyroid carcinoma (PTC) and thyroid tumors of uncertain malignant potential (TT-UMP) ..
  5. Ulfig N, Chan W. Expression patterns of PSA-NCAM in the human ganglionic eminence and its vicinity: role of PSA-NCAM in neuronal migration and axonal growth?. Cells Tissues Organs. 2004;177:229-36 pubmed
    ..To investigate the roles of the highly polysialylated isoform of the neural cell adhesion molecule (PSA-NCAM) in cell migration and axonal growth within the GE and its neighbouring structures, the spatio-temporal expression ..
  6. Beggs H, Baragona S, Hemperly J, Maness P. NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn). J Biol Chem. 1997;272:8310-9 pubmed
    ..Neurite outgrowth mediated by the neural cell adhesion molecule (NCAM) requires the src family tyrosine kinase p59(fyn) in nerve growth cones, but the molecular basis for this ..
  7. Dalbeth N, Gundle R, Davies R, Lee Y, McMichael A, Callan M. CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. J Immunol. 2004;173:6418-26 pubmed
    Human NK cells may be divided into a CD56(dim) subset and a CD56(bright) subset. In peripheral blood, CD56(dim) NK cells dominate, whereas in lymph nodes, CD56(bright) NK cells are more common...
  8. Lemster B, Michel J, Montag D, Paat J, Studenski S, Newman A, et al. Induction of CD56 and TCR-independent activation of T cells with aging. J Immunol. 2008;180:1979-90 pubmed
    ..Monitoring of T cells driven to senescence showed de novo induction of CD56, the prototypic receptor of NK cells...
  9. Alexander A, Maniar A, Cummings J, Hebbeler A, Schulze D, Gastman B, et al. Isopentenyl pyrophosphate-activated CD56+ {gamma}{delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma. Clin Cancer Res. 2008;14:4232-40 pubmed publisher
    The expression of CD56, a natural killer cell-associated molecule, on alphabeta T lymphocytes correlates with their increased antitumor effector function. CD56 is also expressed on a subset of gammadelta T cells...

More Information

Publications121 found, 100 shown here

  1. Cox E, Brennaman L, Gable K, Hamer R, Glantz L, LaMantia A, et al. Developmental regulation of neural cell adhesion molecule in human prefrontal cortex. Neuroscience. 2009;162:96-105 pubmed publisher
    Neural cell adhesion molecule (NCAM) is a membrane-bound cell recognition molecule that exerts important functions in normal neurodevelopment including cell migration, neurite outgrowth, axon fasciculation, and synaptic plasticity...
  2. Dickson G, Gower H, Barton C, Prentice H, Elsom V, Moore S, et al. Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain. Cell. 1987;50:1119-30 pubmed
    ..7 kb muscle transcript. The MSD1 is also absent from chick and mouse brain mRNAs of 4.0 and 2.9 kb. These results show that diversity in N-CAM primary structure can be found in the extracellular domain in a tissue-specific manner. ..
  3. Rønn L, Hartz B, Bock E. The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system. Exp Gerontol. 1998;33:853-64 pubmed
    The neural cell adhesion molecule (NCAM) is a member of the immunoglobulin superfamily and is strongly expressed in the nervous system...
  4. Prag S, Lepekhin E, Kolkova K, Hartmann Petersen R, Kawa A, Walmod P, et al. NCAM regulates cell motility. J Cell Sci. 2002;115:283-92 pubmed
    ..We show here that expression of or exposure to the neural cell adhesion molecule (NCAM) strongly affected the motile behaviour of glioma cells independently of homophilic NCAM interactions...
  5. Kos F, Chin C. Costimulation of T cell receptor-triggered IL-2 production by Jurkat T cells via fibroblast growth factor receptor 1 upon its engagement by CD56. Immunol Cell Biol. 2002;80:364-9 pubmed
    Recent studies have demonstrated that neural cell adhesion molecule (NCAM) is involved in multiple adhesive interactions with several different classes of ligands on the cell surface and in the extracellular matrix...
  6. Leshchyns ka I, Sytnyk V, Morrow J, Schachner M. Neural cell adhesion molecule (NCAM) association with PKCbeta2 via betaI spectrin is implicated in NCAM-mediated neurite outgrowth. J Cell Biol. 2003;161:625-39 pubmed
    In hippocampal neurons and transfected CHO cells, neural cell adhesion molecule (NCAM) 120, NCAM140, and NCAM180 form Triton X-100-insoluble complexes with betaI spectrin...
  7. Singh J, Kaur G. Neuroprotection mediated by subtoxic dose of NMDA in SH-SY5Y neuroblastoma cultures: activity-dependent regulation of PSA-NCAM expression. Brain Res Mol Brain Res. 2005;137:223-34 pubmed
    ..NMDA receptor stimulation has been shown to regulate polysialylated neural cell adhesion molecule (PSA-NCAM) expression in glial cell cultures and in hippocampal slice cultures...
  8. Sanchez Heras E, Howell F, Williams G, Doherty P. The fibroblast growth factor receptor acid box is essential for interactions with N-cadherin and all of the major isoforms of neural cell adhesion molecule. J Biol Chem. 2006;281:35208-16 pubmed
    Interactions between the neural cell adhesion molecules NCAM and N-cadherin with the fibroblast growth factor receptor (FGFR) are important for a number of developmental events and have also been implicated in tumor progression...
  9. Varea E, Castillo Gomez E, Gomez Climent M, Blasco Ibáñez J, Crespo C, Martínez Guijarro F, et al. PSA-NCAM expression in the human prefrontal cortex. J Chem Neuroanat. 2007;33:202-9 pubmed
    ..The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) may mediate these structural changes through its anti-adhesive properties...
  10. Jakovcevski I, Mo Z, Zecevic N. Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain. Neuroscience. 2007;149:328-37 pubmed
    ..The polysialic acid (PSA) modification of neural cell adhesion molecule, which reduces neural cell adhesion molecule (NCAM) - mediated cell adhesion, is involved in several developmental processes, such as cell migration, axonal growth, ..
  11. Dec K, Łukomska A, Maciejewska D, Jakubczyk K, Baranowska Bosiacka I, Chlubek D, et al. The Influence of Fluorine on the Disturbances of Homeostasis in the Central Nervous System. Biol Trace Elem Res. 2017;177:224-234 pubmed publisher
    ..and the activation of apoptosis through the changes in the expression of neural cell adhesion molecules (NCAM), glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF) and MAP kinases...
  12. Naftolin F, Mehr H, Fadiel A. Sex Steroids Block the Initiation of Atherosclerosis. Reprod Sci. 2016;23:1620-1625 pubmed
    ..recruited cells are circulating monocytes that may be captured by the formation of neural cell adhesion molecule (nCAM) tethers between the monocytes and vascular endothelium; the tethers are dependent on electrostatic binding between ..
  13. Chocyk A, Dudys D, Przyborowska A, Maćkowiak M, Wędzony K. Impact of maternal separation on neural cell adhesion molecules expression in dopaminergic brain regions of juvenile, adolescent and adult rats. Pharmacol Rep. 2010;62:1218-24 pubmed
    ..Neural cell adhesion molecules (NCAM 120, 140, 180 kDa) are known to play an important role in normal brain development and synaptic plasticity...
  14. Yang X, Liang S, Wang L, Han P, Jiang X, Wang J, et al. Sialic acid and anti-ganglioside antibody levels in children with autism spectrum disorders. Brain Res. 2018;1678:273-277 pubmed publisher
    ..nutrient for early brain development, and its polymer polySia (PSA) can modify neural cell adhesion molecules (NCAM), thereby indirectly mediating neuronal outgrowth, synaptic connectivity and memory formation...
  15. Chooi W, Chew S. Modulation of cell-cell interactions for neural tissue engineering: Potential therapeutic applications of cell adhesion molecules in nerve regeneration. Biomaterials. 2019;197:327-344 pubmed publisher
    ..cell-cell interactions through cell adhesion molecules (CAMs) such as cadherins, neural cell adhesion molecules (NCAM) and L1, may be a potential alternative to improve nerve regeneration...
  16. Zhu X, Chen Y, Zhang N, Zheng Z, Zhao F, Liu N, et al. Molecular characterization and expression analyses of ST8Sia II and IV in piglets during postnatal development: lack of correlation between transcription and posttranslational levels. Glycoconj J. 2015;32:715-28 pubmed publisher
    ..clone the coding sequence of the piglet ST8Sia II and determine the mRNA expression levels of ST8Sia II, ST8Sia IV, NCAM and neuropilin-2 (NRP-2), also a carrier protein of polySia, during postnatal development...
  17. Sytnyk V, Leshchyns ka I, Schachner M. Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function. Trends Neurosci. 2017;40:295-308 pubmed publisher
    ..Prominent family members are the neural cell adhesion molecules NCAM and L1, which were the first to be shown to be essential not only in development but also in synaptic function and ..
  18. Gnanapavan S, Giovannoni G. Neural cell adhesion molecules in brain plasticity and disease. Mult Scler Relat Disord. 2013;2:13-20 pubmed publisher
    Neural cell adhesion molecule (NCAM) has been studied extensively...
  19. Balineni P, Arcot R, Devygounder K, Rahaman K, Narayansamy B, Prabhu M, et al. Malignant peripheral nerve sheath tumor of the pancreas-A case report. Int J Surg Case Rep. 2019;55:239-242 pubmed publisher
    ..Microscopically they show Antoni A & B areas. They demonstrate S100, vimentin, CD56 positivity. Most common differential diagnosis are cystic mucinous / serous neoplasms of pancreas...
  20. Zhou G, Huang R, Troy F. 3D structural conformation and functional domains of polysialyltransferase ST8Sia IV required for polysialylation of neural cell adhesion molecules. Protein Pept Lett. 2015;22:137-48 pubmed
    ..on N- and Olinked oligosaccharide chains on acceptor glycoproteins, including the neural cell adhesion molecule (NCAM), which is the major carrier protein of polySia...
  21. Zueva E, Kairbayeva M, Nikogosyan S, Mozhenkova A, Digaeva M, Tereshkina I, et al. Immunological peculiarities of CD-56-positive serous ovarian adenocarcinoma. Bull Exp Biol Med. 2010;149:604-8 pubmed
    Here we present the results of evaluation of the expression of neural cell adhesion molecules CD56 (NCAM) in serous ovarian adenocarcinoma. The expression was detected in 48.5% cases...
  22. Su X, Lin R, Xu X, Chen X, Zhan W, Zheng J, et al. [Analysis of cell morphology and immunophenotypic characteristics in 47 cases of multiple myeloma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:137-41 pubmed publisher
    ..technique, and CD45/SSC and CD38(+)(+)/CD138(+) gating were used to measure cell markers CD138, CD38, CD56, CD117, CD3, CD13, CD33, CD19, CD7, CD20, CD22, CD34, CD28 in 47 MM patients...
  23. Crossland D, Denning W, Ang S, Olivares S, Mi T, Switzer K, et al. Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models. Oncogene. 2018;37:3686-3697 pubmed publisher
    The CD56 antigen (NCAM-1) is highly expressed on several malignancies with neuronal or neuroendocrine differentiation, including small-cell lung cancer and neuroblastoma, tumor types for which new therapeutic options are needed...
  24. Saito T, Tsuta K, Fukumoto K, Matsui H, Konobu T, Torii Y, et al. Combined small cell lung carcinoma and giant cell carcinoma: a case report. Surg Case Rep. 2017;3:52 pubmed publisher
    ..and p40-negative and exhibited neuroendocrine differentiation, as indicated by positivity for synaptophysin and CD56 and negativity for chromogranin A...
  25. Maenhout T, Moreau E, Van Haute I, Desmet S, Deeren D. Minimal Coexpression of CD34+/CD56+ in Acute Promyelocytic Leukemia Is Associated With Relapse. Am J Clin Pathol. 2015;144:347-51 pubmed publisher
    Surface CD56 expression on leukemic cells in acute promyelocytic leukemia (APML) is considered an indicator of poorer outcome even in patients receiving conventional treatment...
  26. Ozaki Y, Miura Y, Koganemaru S, Suyama K, Inoshita N, Fujii T, et al. Ewing sarcoma of the liver with multilocular cystic mass formation: a case report. BMC Cancer. 2015;15:16 pubmed publisher
    ..2, as well as the neuroendocrine markers, CD56 and synaptophysin...
  27. Ding C, Li H, Wang Y, Wang F, Wu H, Chen R, et al. Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics. Stem Cell Res Ther. 2017;8:173 pubmed publisher
    ..FOXL2, and CYP19A1) and immunological rejection of human peripheral blood mononuclear cells (CD4, CD11b, CD19, and CD56) were measured by flow cytometry (fluorescence-activated cell sorting (FACS))...
  28. Pode Shakked N, Metsuyanim S, Rom Gross E, Mor Y, Fridman E, Goldstein I, et al. Developmental tumourigenesis: NCAM as a putative marker for the malignant renal stem/progenitor cell population. J Cell Mol Med. 2009;13:1792-808 pubmed
    ..Drosophila] - FZD2, FZD7, G-protein coupled receptor 39, activin receptor type 2B, neural cell adhesion molecule - NCAM)...
  29. Bhardwaj S, Ahmad F, Wedemeyer H, Cornberg M, Schulze zur Wiesch J, van Lunzen J, et al. Increased CD56(bright) NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype. Virol J. 2016;13:67 pubmed publisher
    ..evaluated the effect of HIV-HCV co-infection on peripheral blood NK cell subsets with emphasis on the phenotype of CD56(bright) NK cells...
  30. Albayrak M, Sahin Balçık O, Dagdas S, Yilmaz M, Ceran F, Yokus O, et al. Role of flow cytometry in multiple myeloma and the prognostic significance of CD87 (uPAR) expression. Turk J Haematol. 2010;27:182-9 pubmed publisher
    ..The aim of this study was to determine the significance of flow cytometry and CD87, CD45 and CD56 expressions in the diagnosis, follow-up and prognosis of multiple myeloma (MM)...
  31. Fu B, Wei H. Decidual natural killer cells and the immune microenvironment at the maternal-fetal interface. Sci China Life Sci. 2016;59:1224-1231 pubmed
    ..In particular, a unique population of NK cells with a CD56brightCD16- phenotype in the decidua has been proposed to play a key role in the maternal ..
  32. Honkanen T, Moilanen T, Karihtala P, Tiainen S, Auvinen P, Väyrynen J, et al. Prognostic and predictive role of spatially positioned tumour infiltrating lymphocytes in metastatic HER2 positive breast cancer treated with trastuzumab. Sci Rep. 2017;7:18027 pubmed publisher
    ..The tumours were immunostained for T-cell (CD3, CD8), natural killer (NK)-cell (CD56) and macrophage (CD68) markers and quantitative analysis of the immune cells was carried out using a computer-..
  33. Vawter M, Usen N, Thatcher L, Ladenheim B, Zhang P, VanderPutten D, et al. Characterization of human cleaved N-CAM and association with schizophrenia. Exp Neurol. 2001;172:29-46 pubmed
    ..Alternatively, the increases in cN-CAM in schizophrenia may be a reflection of a more general abnormality in the regulation of proteolysis or of extracellular matrix stability. ..
  34. Tomita S, Kikuti Y, Carreras J, Kojima M, Ando K, Takasaki H, et al. Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan. Mod Pathol. 2015;28:1286-96 pubmed publisher
    ..The immunophenotype was CD2(+) (60%), CD3ɛ(+) (100%), CD4(+) (10%), CD7(+) (95%), CD8(+) (80%), CD56(+) (85%), TIA-1(+) (100%), Granzyme B(+) (25%), T-cell receptor (TCR)β(+) (10%), TCRγ(+) (35%), TCRγδ(+)..
  35. Falasca K, Vecchiet J, Ucciferri C, Di Nicola M, D Angelo C, Reale M. Effect of Probiotic Supplement on Cytokine Levels in HIV-Infected Individuals: A Preliminary Study. Nutrients. 2015;7:8335-47 pubmed publisher
    ..The probiotic LcS was associated with an increase of T lymphocytes and a significant increase of CD56+ cells (p = 0.04). There was also a significant decrease of mRNA levels of TGFβ, IL-10 and IL-12 (p < 0...
  36. Mahmoud R, Wainwright S, Chaiton J, Lieblich S, Galea L. Ovarian hormones, but not fluoxetine, impart resilience within a chronic unpredictable stress model in middle-aged female rats. Neuropharmacology. 2016;107:278-293 pubmed publisher
    ..neurogenesis (via cell survival), and the expression of the polysialylated neuronal cell adhesion molecule (PSA-NCAM) in the dentate gyrus, although these effects varied by region (dorsal, ventral) and ovarian status...
  37. Shirshev S, Nekrasova I, Orlova E, Gorbunova O. Roles of leptin and ghrelin in the regulation of the phenotype and cytokine production by NK cells from peripheral blood. Dokl Biol Sci. 2016;470:249-252 pubmed
    ..used separately at the concentrations corresponding to trimesters II-III of pregnancy increase the number of CD56bright NK cells in mononuclear cell suspension; their combination also enhances the L-selectin expression ..
  38. Egashira A, Morita M, Kumagai R, Taguchi K, Ueda M, Yamaguchi S, et al. Neuroendocrine carcinoma of the esophagus: Clinicopathological and immunohistochemical features of 14 cases. PLoS ONE. 2017;12:e0173501 pubmed publisher
    ..3%), 13 cases (91.7%) and 12 cases (83.3%) showed positive immunostaining for choromogranin A, synaptophysin and CD56, respectively. Nine of 14 cases (64...
  39. Svajdler M, Mezencev R, Ondic O, Saskova B, Mukensnabl P, Michal M. P16 is a useful supplemental diagnostic marker of pulmonary small cell carcinoma in small biopsies and cytology specimens. Ann Diagn Pathol. 2018;33:23-29 pubmed publisher
    ..We examined the expression of p16, CD56, synaptophysin (SYP), chromogranin A and thyroid transcription factor-1 (TTF1) in a series of pulmonary and ..
  40. Ribas A, Shin D, Zaretsky J, Frederiksen J, Cornish A, Avramis E, et al. PD-1 Blockade Expands Intratumoral Memory T Cells. Cancer Immunol Res. 2016;4:194-203 pubmed publisher
    ..In peripheral blood, an unusual population of blood cells expressing CD56 was detected in two patients with regressing melanoma...
  41. Du H, Shi Y, Shi Y. [Clinicopathologic characteristics and immunophenotypes of histiocytic necrotizing lymphadenitis: an analysis of 84 cases]. Zhonghua Bing Li Xue Za Zhi. 2016;45:86-90 pubmed publisher
    ..Immunohistochemical staining using EliVision method for CD20, PAX5, CD3, CD45RO, CD4, CD8, CD56, CD68, CD123, granzyme-B, TIA1 and MPO was carried out...
  42. Offersen R, Nissen S, Rasmussen T, Østergaard L, Denton P, Søgaard O, et al. A Novel Toll-Like Receptor 9 Agonist, MGN1703, Enhances HIV-1 Transcription and NK Cell-Mediated Inhibition of HIV-1-Infected Autologous CD4+ T Cells. J Virol. 2016;90:4441-4453 pubmed publisher
    ..0005) in culture supernatants. Within the incubated PBMC pool, there were higher proportions of CD69-positive CD56(dim)CD16(+)NK cells (P= 0.001) as well as higher proportions of CD107a-positive (P= 0...
  43. Pode Shakked N, Pleniceanu O, Gershon R, Shukrun R, Kanter I, Bucris E, et al. Dissecting Stages of Human Kidney Development and Tumorigenesis with Surface Markers Affords Simple Prospective Purification of Nephron Stem Cells. Sci Rep. 2016;6:23562 pubmed publisher
    ..Thus, negative selection for CD133 is required for defining NCAM1(+) nephron stem cells in normal and malignant nephrogenesis. ..
  44. Zheng F, Li J, Zha H, Zhang J, Zhang Z, Cheng F. ITK Gene Mutation: Effect on Survival of Children with Severe Hemophagocytic Lymphohistiocytosis. Indian J Pediatr. 2016;83:1349-1352 pubmed
    ..3 ± 2.9 %) and CD16+CD56+ NK cells (8.4 ± 2.6 %) than ITK - mutation group (29...
  45. Rodríguez Alvarez Y, Morera Díaz Y, Gerónimo Perez H, Castro Velazco J, Martínez Castillo R, Puente Pérez P, et al. Active immunization with human interleukin-15 induces neutralizing antibodies in non-human primates. BMC Immunol. 2016;17:30 pubmed
    ..behavior, clinical status, blood biochemistry nor the percentage of IL-15-dependent cell populations, specifically CD56+ NK and CD8+ T cells...
  46. Matsuyama A, Shiba E, Umekita Y, Nosaka K, Kamio T, Yanai H, et al. Clinicopathologic Diversity of Undifferentiated Sarcoma With BCOR-CCNB3 Fusion: Analysis of 11 Cases With a Reappraisal of the Utility of Immunohistochemistry for BCOR and CCNB3. Am J Surg Pathol. 2017;41:1713-1721 pubmed publisher
    ..Tumor cells were immunoreactive to CCNB3 (9/11), BCOR (10/10), TLE1 (6/10), bcl-2 (9/11), CD99 (8/10), CD56 (8/10), c-kit (4/10), and cyclin D1 (10/10)...
  47. Oguntunde P, Adejumo O, Odetunmibi O, Okagbue H, Adejumo A. Data analysis on physical and mechanical properties of cassava pellets. Data Brief. 2018;16:286-302 pubmed publisher
    ..laboratory experimental investigation results carried out at National Centre for Agricultural Mechanization (NCAM) on moisture content, machine speed, die diameter of the rig, and the outputs (hardness, durability, bulk density, ..
  48. Matsubara K, Yura K, Hirata T, Nigami H, Harigaya H, Nozaki H, et al. Acute lymphoblastic leukemia with coexpression of CD56 and CD57: case report. Pediatr Hematol Oncol. 2004;21:677-82 pubmed
    ..These cells were positive for B-precursor-cell (CD10, CD19) antigens and natural killer cells (CD56, CD57)...
  49. Sjöstrand D, Ibanez C. Insights into GFRalpha1 regulation of neural cell adhesion molecule (NCAM) function from structure-function analysis of the NCAM/GFRalpha1 receptor complex. J Biol Chem. 2008;283:13792-8 pubmed publisher
    The neural cell adhesion molecule NCAM binds glial cell line-derived neurotrophic factor (GDNF) through specific determinants located in its third immunoglobulin (Ig) domain...
  50. Kaese M, Galuska C, Simon P, Braun B, Cabrera Fuentes H, Middendorff R, et al. Polysialylation takes place in granulosa cells during apoptotic processes of atretic tertiary follicles. FEBS J. 2015;282:4595-606 pubmed publisher
    ..sugar moiety is mainly present as a post-translational modification of the neural cell adhesion molecule (NCAM). More than 20 years ago, differently glycosylated forms of NCAM were detected in the ovaries...
  51. Uehara K, Ikehara F, Tanabe Y, Nakazato I, Oshiro M, Inamine M, et al. CD10 expression in the neuroendocrine carcinoma component of endometrial mixed carcinoma: association with long survival. Diagn Pathol. 2016;11:16 pubmed publisher
    ..In addition to CD56 and synaptophysin expression, the NEC component was positive for CD10 but negative for estrogen receptor (ER), ..
  52. Deborde S, Omelchenko T, Lyubchik A, Zhou Y, He S, McNamara W, et al. Schwann cells induce cancer cell dispersion and invasion. J Clin Invest. 2016;126:1538-54 pubmed publisher
    ..The formation of these processes was dependent on Schwann cell expression of neural cell adhesion molecule 1 (NCAM1) and ultimately promoted perineural invasion...
  53. Baldassari L, Rose J. Daclizumab: Development, Clinical Trials, and Practical Aspects of Use in Multiple Sclerosis. Neurotherapeutics. 2017;14:842-858 pubmed publisher
    ..its effects via multiple mechanisms, including reduction of IL-2-mediated lymphocyte activation and upregulation of CD56-bright natural killer cells...
  54. Chen S, Li C, Chuang S, Tzeng C, Hsieh Y, Lee P, et al. Aberrant co-expression of CD19 and CD56 as surrogate markers of acute myeloid leukemias with t(8;21) in Taiwan. Int J Lab Hematol. 2008;30:133-8 pubmed publisher
    ..Among 111 cases, 58 (52%) showed aberrant antigen expression, most frequently CD7 (27%) and CD56 (23%)...
  55. Mou W, He J, Chen X, Zhang H, Ren X, Wu X, et al. A novel deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency with an atypical phenotype. Immunogenetics. 2017;69:29-38 pubmed publisher
    ..NK cells, however, exhibited a skewed development toward immature CD3-CD16+CD56- cells. Genetic analysis revealed a novel deletion at nucleotide 52 in exon 1 of IL2RG gene...
  56. Cho M, Kim S, Park W, Joung J, Seo H, Chung J, et al. Bladder chondrosarcoma plus urothelial carcinoma in recurred transitional cell carcinoma of the upper urinary tract: a case report and literature review. World J Surg Oncol. 2016;14:270 pubmed
    ..Immunohistochemical examination showed that tumor cells were positive for vimentin and p63 and negative for NSE and Cd56 markers. In the first postoperative month, a metastatic lung nodule was detected on chest CT...
  57. Murakami M, Katayama K, Kato S, Fujimoto D, Morikawa M, Koneri K, et al. Large-cell neuroendocrine carcinoma of the common bile duct: a case report and a review of literature. Surg Case Rep. 2016;2:141 pubmed
    ..Immunohistochemically, the LCNEC cells were reactive for CD56 and synaptophysin and had a high MIB-1 index (72%)...
  58. Nowak I, Wilczyńska K, Wilczynski J, Malinowski A, Radwan P, Radwan M, et al. KIR, LILRB and their Ligands' Genes as Potential Biomarkers in Recurrent Implantation Failure. Arch Immunol Ther Exp (Warsz). 2017;65:391-399 pubmed publisher
    ..The majority of these cells are of CD56bright phenotype...
  59. Barros Romão C, Santos Júnior C, Leite L, Gomes Alves M, Araújo N, Castro A, et al. Blastic Plasmacytoid Dendritic Cell Neoplasm with Pulmonary Involvement and Atypical Skin Lesion. Am J Case Rep. 2017;18:692-695 pubmed
    ..Flow cytometry from circulating blastic cells was compatible with BPDCN (CD4+, CD56+ and CD123+)...
  60. Cunningham C, Srivastava A, Collin E, Grad S, Alini M, Pandit A, et al. Isolation and characterisation of a recombinant antibody fragment that binds NCAM1-expressing intervertebral disc cells. PLoS ONE. 2013;8:e83678 pubmed publisher
    ..The most cell-distal domain of neural cell adhesion molecule 1 (NCAM1) was cloned and expressed in Escherichia coli...
  61. Matthai S, Ramakrishna B. Cancer stem cells in hepatocellular carcinoma--an immunohistochemical study with histopathological association. Indian J Med Res. 2015;142:391-8 pubmed publisher
    ..adhesion molecule), liver progenitor cell (LPC) markers CK19 (cytokeratin 19) and neural cell adhesion molecule (NCAM) were performed and were associated with histological features of tumour behaviour. Thirty three tumours (41...
  62. Zhang X, Cheng H, Bao Y, Tang F, Wang Y. [Diagnostic value of STAT6 immunohistochemistry in solitary fibrous tumor/meningeal hemangiopericytoma]. Zhonghua Bing Li Xue Za Zhi. 2016;45:97-101 pubmed publisher
    ..Evaluated the expression of STAT6, vimentin, CD34, EMA, PR, S-100, CD56, GFAP and Ki-67 in a cohort of 37 SFT/meningeal HPC, 30 meningiomas and 30 schwannomas by immunohistochemistry ..
  63. Drylewicz J, Schellens I, Gaiser R, Nanlohy N, Quakkelaar E, Otten H, et al. Rapid reconstitution of CD4 T cells and NK cells protects against CMV-reactivation after allogeneic stem cell transplantation. J Transl Med. 2016;14:230 pubmed publisher
    ..end, 116 patients were prospectively sampled for absolute T cell (CD4 and CD8), B-cell (CD19) and NK-cell (CD16 and CD56) numbers weekly post-SCT during the first 3 months and thereafter monthly until 6 months post-SCT...
  64. Berens C, Heine A, Muller J, Held S, Mayer K, Brossart P, et al. Variable resistance to freezing and thawing of CD34-positive stem cells and lymphocyte subpopulations in leukapheresis products. Cytotherapy. 2016;18:1325-31 pubmed publisher
    ..the post-thaw recoveries of CD34(+) cells, CD3(+)CD4(+) cells, CD3(+)CD8(+) cells, CD19(+) cells and CD16(+)CD56(+) cells were determined in 90 cryopreserved apheresis products, among which 65 were from G-CSF-mobilized donors, ..
  65. Wang J, Miao Y, Huang Y, Lin B, Liu X, Xiao S, et al. Bottom-up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration. Adv Healthc Mater. 2017;: pubmed publisher
    ..The markers ALP, Versican, and NCAM are examined to investigate that high-passaged (P8) DP spheroids can restore the hair induction potential, which ..
  66. Ono T, Takeshita A, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, et al. Expression of CD56 is an unfavorable prognostic factor for acute promyelocytic leukemia with higher initial white blood cell counts. Cancer Sci. 2014;105:97-104 pubmed publisher
    Expression of CD56 has recently been introduced as one of the adverse prognostic factors in acute promyelocytic leukemia (APL). However, the clinical significance of CD56 antigen in APL has not been well elucidated...
  67. Verma C, Kaewkangsadan V, Eremin J, Cowley G, Ilyas M, El Sheemy M, et al. Natural killer (NK) cell profiles in blood and tumour in women with large and locally advanced breast cancer (LLABC) and their contribution to a pathological complete response (PCR) in the tumour following neoadjuvant chemotherapy (NAC): differential. J Transl Med. 2015;13:180 pubmed publisher
    ..005) showing a significant correlation (p = 0.004) between CD56(+) cells and grade of response. Tumour cytokines had no effect...
  68. Martner A, Rydström A, Riise R, Aurelius J, Brune M, Foa R, et al. NK cell expression of natural cytotoxicity receptors may determine relapse risk in older AML patients undergoing immunotherapy for remission maintenance. Oncotarget. 2015;6:42569-74 pubmed publisher
    ..old, n = 37) and older patients (>60 years old, n = 47), treatment with HDC/IL-2 resulted in an expansion of CD56(bright) and CD16+ NK cells in blood along with an increased NK cell expression of the natural cytotoxicity ..
  69. Niu R, Chen H, Manthari R, Sun Z, Wang J, Zhang J, et al. Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus. Chemosphere. 2018;194:628-633 pubmed publisher
    ..element-binding protein (CREB), brain-derived neurotrophic factor (BDNF), and neural cell adhesion molecule (NCAM)...
  70. Gelernter J, Yu Y, Weiss R, Brady K, Panhuysen C, Yang B, et al. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. Hum Mol Genet. 2006;15:3498-507 pubmed
    ..Functional studies of these loci are warranted. These results provide additional information useful in evaluating the many earlier discrepant findings regarding association of DRD2 with substance dependence. ..
  71. Yoo K, Lee T, Yang M, Park E, Yook Y, Lee H, et al. NCAM as a cystogenesis marker gene of PKD2 overexpression. BMB Rep. 2008;41:593-6 pubmed
    ..b>NCAM (neuronal cell adhesion molecule) levels were significantly reduced in PKD2 overexpressing systems in vitro and in ..
  72. Fernández Briera A, García Parceiro I, Cuevas E, Gil Martin E. Effect of human colorectal carcinogenesis on the neural cell adhesion molecule expression and polysialylation. Oncology. 2010;78:196-204 pubmed publisher
    Although downregulation of neural cell adhesion molecule (NCAM) has been correlated with poor prognosis in colorectal cancer (CRC), it is also possible that colon cancer spreading comes from reducing tumor cell adhesion through NCAM ..
  73. Gilabert Juan J, Varea E, Guirado R, Blasco Ibáñez J, Crespo C, Nacher J. Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients. Neurosci Lett. 2012;530:97-102 pubmed publisher
    ..Changes in the structure of these networks may be mediated by the polysialylated neural cell adhesion molecule (PSA-NCAM), a molecule related to neuronal structural plasticity, expressed in the PFC exclusively by interneurons...
  74. Fragiadakis G, Baca Q, Gherardini P, Ganio E, Gaudilliere D, Tingle M, et al. Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy. J Immunol. 2016;197:4482-4492 pubmed
    ..and CREB phosphorylation in fetal Tbet+CD4+ T cells, CD8+ T cells, B cells, and CD56loCD16+ NK cells and decreased ERK1/2, MAPK-activated protein kinase 2, and STAT1 ..
  75. Bhide G, Prehna G, Ramirez B, Colley K. The Polybasic Region of the Polysialyltransferase ST8Sia-IV Binds Directly to the Neural Cell Adhesion Molecule, NCAM. Biochemistry. 2017;56:1504-1517 pubmed publisher
    ..Our laboratory has previously shown that the neural cell adhesion molecule, NCAM, has an acidic surface patch in its first fibronectin type III repeat (FN1) that is critical for the ..
  76. Petrovska J, Coynel D, Fastenrath M, Milnik A, Auschra B, Egli T, et al. The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals. J Psychiatr Res. 2017;91:116-123 pubmed publisher
  77. Cruz González D, Gómez Martín D, Layseca Espinosa E, Baranda L, Abud Mendoza C, Alcocer Varela J, et al. Analysis of the regulatory function of natural killer cells from patients with systemic lupus erythematosus. Clin Exp Immunol. 2017;: pubmed publisher
    ..We analysed the expression of NK receptors and co-stimulatory molecules in peripheral NK cells (CD3- CD56+ ) from SLE patients, as well as the numbers of human leucocyte antigen D-related (HLA-DR)/CD11c+
  78. Shoae Hassani A, Behfar M, Mortazavi Tabatabaei S, Ai J, Mohseni R, Hamidieh A. Natural Killer Cells from the Subcutaneous Adipose Tissue Underexpress the NKp30 and NKp44 in Obese Persons and Are Less Active against Major Histocompatibility Complex Class I Non-Expressing Neoplastic Cells. Front Immunol. 2017;8:1486 pubmed publisher
    ..experiments on isolated and expanded NKs with IL-2, IL-15, and IL-21 cytokines revealed the main population of the CD56dim within the total ADNKs of obese persons has an under-expression of NKp30 and NKp44 despite the ..
  79. Kojima N, Tachida Y, Yoshida Y, Tsuji S. Characterization of mouse ST8Sia II (STX) as a neural cell adhesion molecule-specific polysialic acid synthase. Requirement of core alpha1,6-linked fucose and a polypeptide chain for polysialylation. J Biol Chem. 1996;271:19457-63 pubmed
    ..1995) FEBS Lett. 373, 119-122, 1995). In this paper, we reported that the neural cell adhesion molecule (NCAM) was specifically polysialylated by a single enzyme, ST8Sia II...
  80. Damiani D, Tiribelli M, Calistri E, Geromin A, Chiarvesio A, Michelutti A, et al. The prognostic value of P-glycoprotein (ABCB) and breast cancer resistance protein (ABCG2) in adults with de novo acute myeloid leukemia with normal karyotype. Haematologica. 2006;91:825-8 pubmed
    ..006) and with CD56. Only PGP, along with age and CD34, affected the achievement of complete remission (p=0...
  81. Arnett D, Meyers K, Devereux R, Tiwari H, Gu C, Vaughan L, et al. Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families. Circ Res. 2011;108:279-83 pubmed publisher
    ..b>NCAM is upregulated during the remodeling period of hypertrophy to heart failure in Dahl salt-sensitive rats...
  82. Djunic I, Virijevic M, Djurasinović V, Novkovic A, Colovic N, Kraguljac Kurtovic N, et al. Prognostic significance of CD56 antigen expression in patients with acute myeloid leukemia. Med Oncol. 2012;29:2077-82 pubmed publisher
    The aims of this study were to investigate the frequency and prognostic relevance of CD56 expression in patients with acute myeloid leukemia (AML) and to compare the importance of CD56 expression with standard prognostic factors, such as ..
  83. Nelson E, Lynskey M, Heath A, Wray N, Agrawal A, Shand F, et al. ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. JAMA Psychiatry. 2013;70:325-33 pubmed publisher
    ..Our findings highlight the necessity of considering drug exposure history when selecting control groups for genetic investigations of illicit drug dependence. ..
  84. Mullins N, Perroud N, Uher R, Butler A, Cohen Woods S, Rivera M, et al. Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study. Am J Med Genet B Neuropsychiatr Genet. 2014;165B:428-37 pubmed publisher
    ..Polygenic score analysis suggests pleiotropy between psychiatric disorders and suicidal ideation whereas the tendency to act on such thoughts may have a partially independent genetic diathesis. ..
  85. Bi J, Li J, Cheng B, Yang H, Ding Q, Wang R, et al. NCAM affects directional lamellipodia formation of BMSCs via ?1 integrin signal-mediated cofilin activity. Mol Cell Biochem. 2017;435:175-183 pubmed publisher
    The neural cell adhesion molecule (NCAM), a key member of the immunoglobulin-like CAM family, was reported to regulate the migration of bone marrow-derived mesenchymal stem cells (BMSCs)...
  86. Aly M, Zhu L, Weimer R, Opelz G, Morath C, Kuon R, et al. Low utility of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in predicting peripheral Treg and Th17 cell counts in ESRD and renal transplant patients. Transpl Immunol. 2017;43-44:3-10 pubmed publisher
    ..The absolute counts of CD4+ and CD8+ T, CD16+ CD56+ NK, CD19+ B, CD4+ CD25+ CD127- Foxp3+ (Tregs), Helios+ Tregs, CD38+ Tregs, and CD4+ CD17+ (Th17) cells were ..
  87. Mori A, Hane M, Niimi Y, Kitajima K, Sato C. Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4. Glycobiology. 2017;27:834-846 pubmed publisher
    Polysialic acid (polySia) is mainly found as a modification of neural cell adhesion molecule (NCAM) in whole embryonic brains, as well as restricted areas of adult vertebrate brains, including the hippocampus...
  88. Ferrero H, Larrayoz I, Martisova E, Solas M, Howlett D, Francis P, et al. Increased Levels of Brain Adrenomedullin in the Neuropathology of Alzheimer's Disease. Mol Neurobiol. 2018;55:5177-5183 pubmed publisher
    ..Frontal cortex from AD patients and controls were studied for AM, acetylated tubulin, NCAM, Ox-42, and neurotransmitters...
  89. Agley C, Lewis F, Jaka O, Lazarus N, Velloso C, Francis West P, et al. Active GSK3? and an intact ?-catenin TCF complex are essential for the differentiation of human myogenic progenitor cells. Sci Rep. 2017;7:13189 pubmed publisher
    ..Here we have used human primary CD56Pos satellite cell-derived myogenic progenitors obtained from healthy individuals to study the role of ..
  90. Espinosa I, De Leo A, D Angelo E, Rosa Rosa J, Corominas M, González A, et al. Dedifferentiated endometrial carcinomas with neuroendocrine features: a clinicopathologic, immunohistochemical, and molecular genetic study. Hum Pathol. 2018;72:100-106 pubmed publisher
    ..the immunophenotype (ARID1A, MLH1, PMS2, MSH2, MSH6, p53, β-catenin, SMARCB1, synaptophysin, chromogranin A, and CD56) and mutational status (PTEN, KRAS, PIK3CA, TP53 and POLE) of 4 dedifferentiated endometrial carcinomas with strong ..
  91. Hata K, Maeno Hikichi Y, Yumoto N, Burden S, Landmesser L. Distinct Roles of Different Presynaptic and Postsynaptic NCAM Isoforms in Early Motoneuron-Myotube Interactions Required for Functional Synapse Formation. J Neurosci. 2018;38:498-510 pubmed publisher
    The neural cell adhesion molecule (NCAM) is expressed both presynaptically and postsynaptically during neuromuscular junction formation...
  92. Izmailov A, Povysheva T, Bashirov F, Sokolov M, Fadeev F, Garifulin R, et al. Spinal Cord Molecular and Cellular Changes Induced by Adenoviral Vector- and Cell-Mediated Triple Gene Therapy after Severe Contusion. Front Pharmacol. 2017;8:813 pubmed publisher
    ..VEGF), glial cell-derived neurotrophic factor (GDNF), angiogenin (ANG), and neuronal cell adhesion molecule (NCAM) applied using both approaches...