CD55

Summary

Gene Symbol: CD55
Description: CD55 molecule (Cromer blood group)
Alias: CHAPLE, CROM, DAF, complement decay-accelerating factor, CD55 antigen, CD55 molecule, decay accelerating factor for complement (Cromer blood group), Cromer blood group antigen
Species: human
Products:     CD55

Top Publications

  1. Taniguchi H, Lowe C, Cooper J, Smyth D, Bailey R, Nutland S, et al. Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes. BMC Genet. 2006;7:22 pubmed
    ..Decay accelerating factor (DAF, CD55), a glycosylphosphatidylinositol-anchored membrane protein, is a candidate for autoimmune disease susceptibility ..
  2. Nowicki S, Izban M, Pawelczyk E, Agboto V, Pratap S, Olson G, et al. Preterm labor: CD55 in maternal blood leukocytes. Am J Reprod Immunol. 2009;61:360-7 pubmed publisher
    ..the association between PTL/PTB and the 'activation' of the peripheral circulatory system by determining whether CD55 mRNA expression within peripheral WBCs differed between PTL and control patients not in labor...
  3. Han S, Xu C, Wu X, Li J, Liu Z, Zeng Q. The impact of expressions of CD97 and its ligand CD55 at the invasion front on prognosis of rectal adenocarcinoma. Int J Colorectal Dis. 2010;25:695-702 pubmed publisher
    ..an important role in tumor differentiation, migration, invasiveness, and metastasis by binding its cellular ligand CD55. CD55 is a complement regulatory protein expressed by cells to protect them from bystander attack by complement, ..
  4. Molina H, Miwa T, Zhou L, Hilliard B, Mastellos D, Maldonado M, et al. Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor. Blood. 2002;100:4544-9 pubmed
    ..C3 regulatory protein, complement receptor 1-related gene/protein y (Crry), but not decay-accelerating factor (DAF), were spontaneously eliminated in vivo by complement...
  5. Liu Y, Chen L, Peng S, Chen Z, Gimm O, Finke R, et al. The expression of CD97EGF and its ligand CD55 on marginal epithelium is related to higher stage and depth of tumor invasion of gastric carcinomas. Oncol Rep. 2005;14:1413-20 pubmed
    CD97EGF is a member of the EGF-TM7 family of class II seven-transmembrane (7TM), and its cellular ligand CD55 (also known as decay accelerating factor; DAF) protects host cells from complement attack...
  6. Osuka F, Endo Y, Higuchi M, Suzuki H, Shio Y, Fujiu K, et al. Molecular cloning and characterization of novel splicing variants of human decay-accelerating factor. Genomics. 2006;88:316-22 pubmed
    Decay-accelerating factor (DAF) is one of the complement regulatory proteins. Two isoforms of DAF have been identified in humans...
  7. Lukacik P, Roversi P, White J, Esser D, Smith G, Billington J, et al. Complement regulation at the molecular level: the structure of decay-accelerating factor. Proc Natl Acad Sci U S A. 2004;101:1279-84 pubmed
    The human complement regulator CD55 is a key molecule protecting self-cells from complement-mediated lysis...
  8. Barros M, Yamamoto M, Figueiredo M, Cançado R, Kimura E, Langhi D, et al. Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-alpha,beta on monocytes from patients with warm autoimmune hemolytic anemia. Transfusion. 2009;49:154-60 pubmed publisher
    ..In contrast, complement-inhibitory proteins such as CD35, CD55, and CD59 may protect RBCs against the lysis by complement...
  9. Lawrence D, Bruyninckx W, Louis N, Lublin D, Stahl G, Parkos C, et al. Antiadhesive role of apical decay-accelerating factor (CD55) in human neutrophil transmigration across mucosal epithelia. J Exp Med. 2003;198:999-1010 pubmed
    ..Microsequence analysis revealed that OE-1 recognized human decay-accelerating factor (DAF, CD55)...

More Information

Publications98

  1. Richaud Patin Y, Pérez Romano B, Carrillo Maravilla E, Rodriguez A, Simon A, Cabiedes J, et al. Deficiency of red cell bound CD55 and CD59 in patients with systemic lupus erythematosus. Immunol Lett. 2003;88:95-9 pubmed
    b>CD55 and CD59 are glycosylphosphatidylinositol-anchored proteins with complement inhibitory properties. Autoimmune hemolytic anemia (AIHA) has been associated with antiphospholipid antibodies (APLA)...
  2. Verbakel C, van Duikeren S, de Bruin R, Marquet R, Ijzermans J. Human decay-accelerating factor expressed on rat hearts inhibits leukocyte adhesion. Transpl Int. 2003;16:168-72 pubmed
    ..the use of donors transgenic for recipient-type complement regulatory protein decay-accelerating factor (DAF/CD55) or membrane co-factor protein (MCP/CD46) protects grafts against hyperacute rejection (HAR), which is primarily ..
  3. Pacheco L, Hankins G, Costantine M, Anderson G, Pawelczyk E, Nowicki S, et al. The role of human decay-accelerating factor in the pathogenesis of preterm labor. Am J Perinatol. 2011;28:565-70 pubmed publisher
    ..Complement activation is thought to contribute to the pathogenesis of preterm labor (PTL). Decay-accelerating factor (DAF) is a natural complement pathway inhibitor...
  4. Spicer A, Seldin M, Gendler S. Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms. J Immunol. 1995;155:3079-91 pubmed
    ..molecule involved in this regulation is a 70-kDa glycoprotein that has been designated decay-accelerating factor (DAF)...
  5. Shenoy Scaria A, Kwong J, Fujita T, Olszowy M, Shaw A, Lublin D. Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1. J Immunol. 1992;149:3535-41 pubmed
    Decay-accelerating factor (DAF or CD55) is a 70-kDa glycosyl-phosphatidylinositol (GPI)-anchored protein that protects cells from complement-mediated lysis by either preventing the formation of or dissociating C3 convertases...
  6. Liu J, Miwa T, Hilliard B, Chen Y, Lambris J, Wells A, et al. The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. J Exp Med. 2005;201:567-77 pubmed
    Decay-accelerating factor ([DAF] CD55) is a glycosylphosphatidylinositol-anchored membrane inhibitor of complement with broad clinical relevance...
  7. Dzietczenia J, Wrobel T, Mazur G, Poręba R, Jazwiec B, Kuliczkowski K. Expression of complement regulatory proteins: CD46, CD55, and CD59 and response to rituximab in patients with CD20+ non-Hodgkin's lymphoma. Med Oncol. 2010;27:743-6 pubmed publisher
    ..Its mechanism of action is related with complement function-complement mediated cytotoxicity. CD46, CD55, and CD59 are complement regulatory proteins...
  8. Clayton A, Harris C, Court J, Mason M, Morgan B. Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur J Immunol. 2003;33:522-31 pubmed
    ..We have examined the expression and functional roles of the membrane regulators of complement (CD46, CD55 and CD59) on antigen-presenting cell-derived exosomes...
  9. Storry J, Sausais L, Hue Roye K, Mudiwa F, Ferrer Z, Blajchman M, et al. GUTI: a new antigen in the Cromer blood group system. Transfusion. 2003;43:340-4 pubmed
    ..system consists of seven high-incidence and three low-incidence antigens carried on decay-accelerating factor (DAF). This report describes the identification and characterization of a new Cromer high-incidence antigen, named GUTI...
  10. Gwamaka M, Fried M, Domingo G, Duffy P. Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia. Malar J. 2011;10:386 pubmed publisher
    ..to investigate whether the changes in glycosylphosphatidylinositol (GPI)-anchored complement regulatory proteins (CD55 and CD59) contributes to malaria anaemia...
  11. Lublin D, Mallinson G, Poole J, Reid M, Thompson E, Ferdman B, et al. Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. Blood. 1994;84:1276-82 pubmed
    ..system Cromer consists of high-incidence and low-incidence antigens that reside on decay-accelerating factor (DAF; CD55), a glycosyl-phosphatidylinositol-anchored membrane protein that regulates complement activation on cell surfaces...
  12. Zhao W, Zhu B, Duan Y, Chen Z. Neutralization of complement regulatory proteins CD55 and CD59 augments therapeutic effect of herceptin against lung carcinoma cells. Oncol Rep. 2009;21:1405-11 pubmed
    ..We found that the expression of membrane complement regulatory proteins (mCRPs), CD55 and CD59 on non-small cell lung cancer (NSCLC) cells was closely correlated with histological types, prognosis and ..
  13. Moran P, Raab H, Kohr W, Caras I. Glycophospholipid membrane anchor attachment. Molecular analysis of the cleavage/attachment site. J Biol Chem. 1991;266:1250-7 pubmed
    The COOH terminus of decay accelerating factor (DAF) contains a signal that directs attachment of a glycophosphatidylinositol (GPI) membrane anchor in a process involving proteolytic removal of 17-31 COOH-terminal residues...
  14. Caras I, Davitz M, Rhee L, Weddell G, Martin D, Nussenzweig V. Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins. Nature. 1987;325:545-9 pubmed
    Decay-accelerating factor (DAF), a glycoprotein that is anchored to the cell membrane by phosphatidylinositol, binds activated complement fragments C3b and C4b, thereby inhibiting amplification of the complement cascade on host cell ..
  15. Kavanagh D, Burgess R, Spitzer D, Richards A, Diaz Torres M, Goodship J, et al. The decay accelerating factor mutation I197V found in hemolytic uraemic syndrome does not impair complement regulation. Mol Immunol. 2007;44:3162-7 pubmed
    ..Decay accelerating factor (DAF; CD55) regulates the complement system by disassociating the alternative and classical pathway convertases...
  16. Mahtout H, Curt S, Chandad F, Rouabhia M, Grenier D. Effect of periodontopathogen lipopolysaccharides and proinflammatory cytokines on CD46, CD55, and CD59 gene/protein expression by oral epithelial cells. FEMS Immunol Med Microbiol. 2011;62:295-303 pubmed publisher
    Membrane-anchored complement regulatory proteins (CRPs), including CD46, CD55, and CD59, protect host cells from complement attack...
  17. Qian Y, Haino M, Kelly K, Song W. Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55). Immunology. 1999;98:303-11 pubmed
    ..motifs, and has been shown to interact with the human complement regulator, decay-accelerating factor (DAF, CD55)...
  18. Hamann J, Vogel B, van Schijndel G, van Lier R. The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF). J Exp Med. 1996;184:1185-9 pubmed
    ..cells was found to be directed to the NH2-terminal short consensus repeat (SCR) of decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade...
  19. Lin F, Kaminski H, Conti Fine B, Wang W, Richmonds C, Medof M. Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay-accelerating factor protection. J Clin Invest. 2002;110:1269-74 pubmed
    ..In this study we investigated whether the presence of decay-accelerating factor (DAF or CD55), an intrinsic complement regulator, protects against the development of disease...
  20. Alegretti A, Mucenic T, Merzoni J, Faulhaber G, Silla L, Xavier R. Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients. Cell Immunol. 2010;265:127-32 pubmed publisher
    b>CD55 and CD59 are glycosylphosphatidylinositol-anchored proteins with complement inhibitory properties. CD55 inhibits the formation of C3 convertases, and CD59 prevents the terminal polymerisation of the membrane attack complex...
  21. Krementsov D, Rassam P, Margeat E, Roy N, Schneider Schaulies J, Milhiet P, et al. HIV-1 assembly differentially alters dynamics and partitioning of tetraspanins and raft components. Traffic. 2010;11:1401-14 pubmed
    ..In contrast, the raft lipid GM1 and the raft-associated protein CD55, while also recruited to assembly/budding sites, were only transiently trapped in these membrane areas...
  22. Prasanth M, Sivamaruthi B, Chaiyasut C, Tencomnao T. A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy. Nutrients. 2019;11: pubmed publisher
    ..Studies using the worm model have suggested that green tea mediated lifespan extension depends on the DAF-16 pathway. Apart from this, green tea has been reported to have stress resistance and neuroprotective properties...
  23. Sobeh M, Mahmoud M, Abdelfattah M, Cheng H, El Shazly A, Wink M. A proanthocyanidin-rich extract from Cassia abbreviata exhibits antioxidant and hepatoprotective activities in vivo. J Ethnopharmacol. 2018;213:38-47 pubmed publisher
    ..2: GFP expression and subcellular DAF-16: GFP localization were investigated to determine the antioxidant activities in vivo...
  24. Kandasamy S, Fan D, Sangha J, Khan W, Evans F, Critchley A, et al. Tasco(®), a product of Ascophyllum nodosum, imparts thermal stress tolerance in Caenorhabditis elegans. Mar Drugs. 2011;9:2256-82 pubmed publisher
    ..However, the TWE treatments did not affect the nematode body length, fertility or the cellular localization of daf-16...
  25. Regal J, Strehlke M, Peterson J, Wing C, Parker J, Nieto N, et al. Role of IgM and angiotensin II Type I receptor autoantibodies in local complement activation in placental ischemia-induced hypertension in the rat. Mol Immunol. 2016;78:38-47 pubmed publisher
    ..real-time polymerase chain reaction (qRT-PCR) to quantitate mRNA for endogenous regulators of complement activation CD55, CD59 and Complement receptor 1-related gene/protein y (Crry). On gestation day (GD)14...
  26. Shi Y, Ye P, Long X. Differential Expression Profiles of the Transcriptome in Breast Cancer Cell Lines Revealed by Next Generation Sequencing. Cell Physiol Biochem. 2017;44:804-816 pubmed publisher
    ..most differential expression, SLPI, SOD2, miR-7, miR-143 and miR-145 were highly expressed in MCF-7 cells, while CD55, KRT17, miR-21, miR-10b, miR-9, NEAT1 and PICSAR were over-expressed in MDA-MB-231 cells...
  27. Zhi L, Yu Y, Jiang Z, Wang D. mir-355 Functions as An Important Link between p38 MAPK Signaling and Insulin Signaling in the Regulation of Innate Immunity. Sci Rep. 2017;7:14560 pubmed publisher
    ..aeruginosa infection. DAF-2 in the insulin signaling pathway acted as a target for intestinal mir-355 to regulate innate immunity...
  28. Kato M, Kashem M, Cheng C. An intestinal microRNA modulates the homeostatic adaptation to chronic oxidative stress in C. elegans. Aging (Albany NY). 2016;8:1979-2005 pubmed publisher
    ..The pathway involved appears to be unique since the canonical stress-responsive factors, such as DAF-16/FOXO, are dispensable for mir-60 loss to enhance oxidative stress resistance...
  29. Liu X, Guo L, Jin L, Liu Y, Liu T, Fan Y, et al. Identification and transcript profiles of citrus growth-regulating factor genes involved in the regulation of leaf and fruit development. Mol Biol Rep. 2016;43:1059-67 pubmed publisher
    ..and 8 increased significantly while the transcript levels of CsGRF2, 3, 7, and 9 had no significant change from 80 DAF to 100 DAF...
  30. Chou H, Vazquez R, Wang K, Campbell R, Milledge G, Walthall W, et al. HES-Mediated Repression of Pten in Caenorhabditis elegans. G3 (Bethesda). 2015;5:2619-28 pubmed publisher
    ..elegans Pten ortholog, daf-18, is one major hub in the network. Finally, we show that HLH-25 regulates C...
  31. Xu H, Kong X, Chen F, Huang J, Lou X, Zhao J. Transcriptome analysis of Brassica napus pod using RNA-Seq and identification of lipid-related candidate genes. BMC Genomics. 2015;16:858 pubmed publisher
    ..The RNA samples were collected for RNA-Seq at 5-7, 15-17 and 25-27 days after flowering (DAF). Bioinformatics analysis was performed to investigate differentially expressed genes (DEGs)...
  32. Kaplan R, Chen Y, Moore B, Jordan J, Maxwell C, Schindler A, et al. dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest. PLoS Genet. 2015;11:e1005731 pubmed publisher
    ..Loss of the transcription factor daf-16/FOXO, an effector of insulin/IGF signaling, results in arrest-defective and starvation-sensitive phenotypes...
  33. Guzzoni V, Cunha T, das Neves V, Briet L, Costa R, Moura M, et al. Nandrolone combined with strenuous resistance training reduces vascular nitric oxide bioavailability and impairs endothelium-dependent vasodilation. Steroids. 2018;131:7-13 pubmed publisher
    ..oxide (NO) and reactive oxygen species (ROS) synthesis were evaluated using 4,5-diaminofluorescein diacetate (DAF-2) and hydroethidine fluorescent techniques, respectively...
  34. Lenz K, Pattison C, Ma H. Triclosan (TCS) and triclocarban (TCC) induce systemic toxic effects in a model organism the nematode Caenorhabditis elegans. Environ Pollut. 2017;231:462-470 pubmed publisher
    ..Using a DAF-16:GFP transgenic strain, we found both compounds induced oxidative stress in the worm, indicated by the ..
  35. Hourcade D, Garcia A, Post T, Taillon Miller P, Holers V, Wagner L, et al. Analysis of the human regulators of complement activation (RCA) gene cluster with yeast artificial chromosomes (YACs). Genomics. 1992;12:289-300 pubmed
    ..The encoded genes and two of the gene-like elements share the same orientation and are ordered (5' to 3') DAF, CR2, CR1, MCP-like, CR1-like, and MCP...
  36. Gao M, Lin L, Chen Y, Wang Y. Digital Gene Expression Profiling to Explore Differentially Expressed Genes Associated with Terpenoid Biosynthesis during Fruit Development in Litsea cubeba. Molecules. 2016;21: pubmed
    ..cubeba. DGE generated expression data for approximately 19354 genes. Fruit at 60 days after flowering (DAF) served as the control, and a total of 415, 1255, 449 and 811 up-regulated genes and 505, 1351, 1823 and 1850 down-..
  37. Massey H, Ranjit N, Stoltzfus J, Lok J. Strongyloides stercoralis daf-2 encodes a divergent ortholog of Caenorhabditis elegans DAF-2. Int J Parasitol. 2013;43:515-20 pubmed publisher
    ..infectious larvae of parasitic nematodes is regulated by signalling pathways homologous to Caenorhabditis elegans DAF (dauer formation) pathways. Alignment of Strongyloides stercoralis (Ss) DAF-2 with DAF-2 of C...
  38. Wang B, Ma L, Wang F, Wang B, Hao X, Xu J, et al. Low Temperature Extends the Lifespan of Bursaphelenchus xylophilus through the cGMP Pathway. Int J Mol Sci. 2017;18: pubmed publisher
    ..The results showed that the deduced protein of Bx-DAF-11 has an adenylate and guanylate cyclase catalytic domain, indicating an ability to bind to extracellular ligands ..
  39. Reid M, Chandrasekaran V, Sausais L, Pierre J, Bullock R. Disappearance of antibodies to Cromer blood group system antigens during mid pregnancy. Vox Sang. 1996;71:48-50 pubmed
    ..antigens that are carried on the complement regulatory glycoprotein called decay-accelerating factor (DAF; CD55)...
  40. Shafren D, Dorahy D, Ingham R, Burns G, Barry R. Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry. J Virol. 1997;71:4736-43 pubmed
    ..addition to binding to ICAM-1, CAV21 binds to the first short consensus repeat (SCR) of decay-accelerating factor (DAF)...
  41. McGehee A, Moss B, Juo P. The DAF-7/TGF-β signaling pathway regulates abundance of the Caenorhabditis elegans glutamate receptor GLR-1. Mol Cell Neurosci. 2015;67:66-74 pubmed publisher
    ..Here we identify a novel role for the Caenorhabditis elegans DAF-7/TGF-β signaling pathway in the regulation of the AMPA-type glutamate receptor GLR-1...
  42. Yu C, How C, Liao V. Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16/FOXO in Caenorhabditis elegans. Chemosphere. 2016;150:632-638 pubmed publisher
    ..1, hsp-16.49, and hsp-70) were increased in aged worms under arsenite exposure (100 μM). Finally, we showed that daf-16 mutant worms were more sensitive to arsenite exposure (100 μM) on lifespan and failed to induce the ..
  43. Woodfield H, Cazenave Gassiot A, Haslam R, Guschina I, Wenk M, Harwood J. Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.). Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:339-348 pubmed publisher
    ..developed, the molecular species distributions changed, especially in the period of early (20days after flowering, DAF) to mid phase (27DAF) of oil accumulation...
  44. Makidono C, Mizuno M, Nasu J, Hiraoka S, Okada H, Yamamoto K, et al. Increased serum concentrations and surface expression on peripheral white blood cells of decay-accelerating factor (CD55) in patients with active ulcerative colitis. J Lab Clin Med. 2004;143:152-8 pubmed
    Inflammatory stimuli induce expression and release of decay-accelerating factor (DAF), a complement-regulatory protein present on peripheral-blood cells...
  45. Narayanan G, Murray I, Krishnegowda G, Amin S, Perdew G. Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure. J Pharmacol Exp Ther. 2012;342:345-55 pubmed publisher
    ..of the AHR with DiMNF can suppress cytokine-mediated induction of the membrane complement regulatory protein CD55. When CD55 is expressed on host cells, it facilitates the decay of the complement component 3 (C3) convertase, ..
  46. Wang J, Zeng G, Huang X, Wang Z, Tan N. 1,4-Naphthoquinone Triggers Nematode Lethality by Inducing Oxidative Stress and Activating Insulin/IGF Signaling Pathway in Caenorhabditis elegans. Molecules. 2017;22: pubmed publisher
    ..on IIS pathway related genes indicated that 1,4-NQ could activate this pathway and suppress the expression of DAF-16 target genes...
  47. Mahajan R, Narain K, Mahanta J. Anaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India. Indian J Med Res. 2011;133:662-4 pubmed
    ..the pathogenesis of anaemia we studied expression level of RBC complement regulatory proteins, CR1 (CD35), CD55 and CD59 with haemoglobin status in a group of malaria cases from Assam, Goa and Chennai, and in healthy controls...
  48. Suzuki Y, Han M. Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development. Genes Dev. 2006;20:423-8 pubmed
    ..We show that at least 27 genes collaborate with the worm PTEN homolog daf-18 for various functions previously concealed by genetic redundancy, including embryogenesis, cuticle turnover, egg ..
  49. Lublin D, Lemons R, Le Beau M, Holers V, Tykocinski M, Medof M, et al. The gene encoding decay-accelerating factor (DAF) is located in the complement-regulatory locus on the long arm of chromosome 1. J Exp Med. 1987;165:1731-6 pubmed
    Delay-accelerating factor (DAF) protects host cells from complement-mediated damage by regulating the activation of C3 convertases on host cell surfaces...
  50. Wang F, Chen H, Li X, Wang N, Wang T, Yang J, et al. Mining and identification of polyunsaturated fatty acid synthesis genes active during camelina seed development using 454 pyrosequencing. BMC Plant Biol. 2015;15:147 pubmed publisher
    ..obtained by de novo assembly, and 12,476 up-regulated and 12,390 down-regulated unigenes were identified in the 20 DAF (days after flowering) library compared with the 10 DAF library...
  51. Doutrelon C, Skopinski S, Boulon C, Constans J, Viallard J, Peffault de Latour R. [Paroxysmal nocturnal hemoglobinuria: An unknown cause of thrombosis?]. J Mal Vasc. 2015;40:384-90 pubmed publisher
    ..The lack of one of the GPI-AP complement regulatory proteins (CD55, CD59) leads to hemolysis. The disease is diagnosed with hemolytic anemia, marrow failure and thrombosis...
  52. Olmedo M, Geibel M, Artal Sanz M, Merrow M. A High-Throughput Method for the Analysis of Larval Developmental Phenotypes in Caenorhabditis elegans. Genetics. 2015;201:443-8 pubmed publisher
    ..was validated with a lin-42 mutant strain that shows delayed development relative to wild-type animals and with a daf-2 mutant that shows an extended second larval stage...
  53. Tataru P, Bataillon T, Hobolth A. Inference Under a Wright-Fisher Model Using an Accurate Beta Approximation. Genetics. 2015;201:1133-41 pubmed publisher
    ..Despite its simple mathematical formulation, exact results for the distribution of allele frequency (DAF) as a function of time are not available in closed analytical form...
  54. Kumar S, Dietrich N, Kornfeld K. Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span. PLoS Genet. 2016;12:e1005866 pubmed publisher
    ..were complex, since the lifespan extensions caused by captopril and reducing acn-1 activity were additive with daf-2 and age-1 but required daf-16...
  55. Asthana J, Yadav D, Pant A, Yadav A, Gupta M, Pandey R. Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. 2016;71:1160-8 pubmed publisher
    ..The effect of ARX on worms with mutations (mev-1, eat-2, sir-2.1, skn-1, daf-16, and hsf-1) indicates that ARX-mediated life-span extension involves mechanisms associated with DR and ..
  56. Selinka H, Wolde A, Sauter M, Kandolf R, Klingel K. Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism. Med Microbiol Immunol. 2004;193:127-31 pubmed
    ..at least two receptor proteins, the coxsackievirus-adenovirus receptor (CAR) and the decay-accelerating factor (DAF), and cause a broad spectrum of diseases, including acute and chronic myocarditis...
  57. O Brien D, Romero Gallo J, Schneider B, Chaturvedi R, Delgado A, Harris E, et al. Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor. J Biol Chem. 2008;283:23922-30 pubmed publisher
    ..Decay-accelerating factor (DAF) is a cellular receptor for H. pylori and a mediator of the inflammatory response to this pathogen. H...
  58. Ludewig A, Gimond C, Judkins J, Thornton S, Pulido D, Micikas R, et al. Larval crowding accelerates C. elegans development and reduces lifespan. PLoS Genet. 2017;13:e1006717 pubmed publisher
    ..In contrast, Pdda is abolished by synthetic ascarosides and steroidal ligands of the nuclear hormone receptor DAF-12...
  59. Pfeiffer A, Bottcher A, Orso E, Kapinsky M, Nagy P, Bodnar A, et al. Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts. Eur J Immunol. 2001;31:3153-64 pubmed
    ..In resting cells, CD14 was associated with CD55, the Fcgamma-receptors CD32 and CD64 and the pentaspan CD47...
  60. Shieh J, Bergelson J. Interaction with decay-accelerating factor facilitates coxsackievirus B infection of polarized epithelial cells. J Virol. 2002;76:9474-80 pubmed
    ..Although some CB isolates also bind to decay-accelerating factor (DAF), the role of DAF interaction during infection remains uncertain...
  61. Guo H, Cao M, Zou S, Ye B, Dong Y. Cranberry Extract Standardized for Proanthocyanidins Alleviates β-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans Model of Alzheimer's Disease. J Gerontol A Biol Sci Med Sci. 2016;71:1564-1573 pubmed
    ..that the cranberry-mediated Aβ toxicity alleviation required heat shock transcription factor (HSF)-1 rather than DAF-16 and SKN-1. Moreover, cranberry supplementation increased the transactivity of HSF-1 in an IIS-dependent manner...
  62. Song H, Zhai X, Gao Z, Lu T, Tian Q, Li H, et al. Reliability and validity of a Coda Motion 3-D Analysis system for measuring cervical range of motion in healthy subjects. J Electromyogr Kinesiol. 2018;38:56-66 pubmed publisher
    In the past two decades, many tools have been reported to measure the cervical range of motion (CROM), but most of the results are controversial in healthy individuals and/or individuals with neck pain...
  63. Stern S, Kirst C, Bargmann C. Neuromodulatory Control of Long-Term Behavioral Patterns and Individuality across Development. Cell. 2017;171:1649-1662.e10 pubmed publisher
    ..Dopamine, serotonin, the neuropeptide receptor NPR-1, and the TGF-? peptide DAF-7 each have stage-specific effects on behavioral trajectories, implying the existence of a modular temporal program ..
  64. Diaz T, Manez R, Moscoso I, Lopez D, Santamarina I, Lopez E, et al. The serum level of xenoantibodies, and hDAF or alphaGAL expression on pig cells, modulate in vitro the protection given by hDAF to primate complement-mediated damage. Transplant Proc. 2005;37:510-1 pubmed
  65. Wang L, Zhong H, Tang N, Pang L, Zhang C, He F. [Interaction between TRPC1 and STIM1 in calcium sensing receptor mediated calcium influx and nitric oxide production in human umbilical vein endothelial cells]. Zhonghua Xin Xue Guan Bing Za Zhi. 2017;45:978-984 pubmed publisher
    ..i)) was detected using the fluorescence Ca(2+) indicator Fura-2/AM, the production of NO was determined by DAF-FM...
  66. Dammermann W, Schipper P, Ullrich S, Fraedrich K, Schulze zur Wiesch J, Fründt T, et al. Increased expression of complement regulators CD55 and CD59 on peripheral blood cells in patients with EAHEC O104:H4 infection. PLoS ONE. 2013;8:e74880 pubmed publisher
    ..prevent hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) caused by a lack of complement-regulating CD55 and CD59 on blood cells...
  67. Anderson K, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, et al. An atomic resolution model for assembly, architecture, and function of the Dr adhesins. Mol Cell. 2004;15:647-57 pubmed
    ..at the bacterial cell surface and target a common host cell receptor, the decay-accelerating factor (DAF or CD55)...
  68. Loberg R, Day L, Dunn R, Kalikin L, Pienta K. Inhibition of decay-accelerating factor (CD55) attenuates prostate cancer growth and survival in vivo. Neoplasia. 2006;8:69-78 pubmed
    Decay-accelerating factor (CD55) is a member of membrane-bound complement-regulatory proteins...
  69. Manez R, Lopez Pelaez E, Centeno A, Herrera J, Juffe A, Domenech N, et al. Transgenic expression in pig hearts of both human decay-accelerating factor and human membrane cofactor protein does not provide an additional benefit to that of human decay-accelerating factor alone in pig-to-baboon xenotransplantation. Transplantation. 2004;78:930-3 pubmed
    ..It is concluded that in this pig-to-baboon heterotopic heart transplant, model expression of hDAF/hMCP does not provide an additional benefit in prevention of rejection to that of hDAF alone. ..
  70. Kawai T, Takeshita S, Imoto Y, Matsumoto Y, Sakashita M, Suzuki D, et al. Associations between decay-accelerating factor polymorphisms and allergic respiratory diseases. Clin Exp Allergy. 2009;39:1508-14 pubmed publisher
    ..Complement systems are known to play an important role in allergic diseases. Decay-accelerating factor (DAF) is important for the regulation of the complement system and is a good candidate for determining the ..
  71. He Y, Lin F, Chipman P, Bator C, Baker T, Shoham M, et al. Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex. Proc Natl Acad Sci U S A. 2002;99:10325-9 pubmed
    Echoviruses are enteroviruses that belong to Picornaviridae. Many echoviruses use decay-accelerating factor (DAF) as their cellular receptor...
  72. Hibshman J, Doan A, Moore B, Kaplan R, Hung A, Webster A, et al. daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival. elife. 2017;6: pubmed publisher
    i>daf-16/FoxO is required to survive starvation in Caenorhabditis elegans, but how daf-16IFoxO promotes starvation resistance is unclear...
  73. Loeschenberger B, Niess L, Wurzner R, Schwelberger H, Eder I, Puhr M, et al. Calcineurin inhibitor-induced complement system activation via ERK1/2 signalling is inhibited by SOCS-3 in human renal tubule cells. Eur J Immunol. 2017;: pubmed publisher
    ..a qPCR array, CNI treatment upregulated C-factors and downregulated SOCS-3 and the complement inhibitors CD46 and CD55. Additionally, ERK1/-2 was required for these regulations...
  74. Ewald C, Castillo Quan J, Blackwell T. Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling. Gerontology. 2017;: pubmed publisher
    ..In this organism, mutations in the insulin/IGF-1 receptor gene daf-2 or other genes in this pathway can double lifespan...
  75. Zeis T, Enz L, Schaeren Wiemers N. The immunomodulatory oligodendrocyte. Brain Res. 2016;1641:139-148 pubmed publisher
    ..g. C1s, C2 and C3, C1R), complement regulatory molecules (e.g. CD46, CD55, CD59), tetraspanins (e.g. TSPAN2), neuroimmune regulatory proteins (e.g...
  76. Sangaletti R, D Amico M, Grant J, Della Morte D, Bianchi L. Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans. PLoS Genet. 2017;13:e1006965 pubmed publisher
    ..3 knock-out is enhanced by block of glycolysis and eliminated by a null mutation in daf-16/FOXO transcription factor, supporting the involvement of the insulin/IGF pathway...
  77. Pekar O, Ow M, Hui K, Noyes M, Hall S, Hubbard E. Linking the environment, DAF-7/TGF? signaling and LAG-2/DSL ligand expression in the germline stem cell niche. Development. 2017;144:2896-2906 pubmed publisher
    ..Neuronal DAF-7/TGF? causes a DAF-1/TGF?R signaling cascade in the gonadal distal tip cell (DTC), the germline stem cell niche, ..
  78. Negi H, Saikia S, Pandey R. 3?-Hydroxy-urs-12-en-28-oic Acid Modulates Dietary Restriction Mediated Longevity and Ameliorates Toxic Protein Aggregation in C. elegans. J Gerontol A Biol Sci Med Sci. 2017;72:1614-1619 pubmed publisher
    ..dietary restriction (DR) achieved through SKN-1/NRF-2 exhibiting upregulation of downstream target genes gcs-1 and daf-9. Longevity mechanism was independent of PHA-4/FOXA and attributed to partial dependence on sir-2.1...
  79. Vicente Salvador D, Puig M, Gayà Vidal M, Pacheco S, Giner Delgado C, Noguera I, et al. Detailed analysis of inversions predicted between two human genomes: errors, real polymorphisms, and their origin and population distribution. Hum Mol Genet. 2017;26:567-581 pubmed publisher
    ..In addition, we determined experimentally the derived allele frequency in Europeans for 17 inversions (DAF?=?0.01-0...
  80. Zhou J, To K, Dong H, Cheng Z, Lau C, Poon V, et al. A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection. J Infect Dis. 2012;206:495-503 pubmed publisher
    ..An initially small-scale genome-wide association study guided the selection of CD55 single-nucleotide polymorphisms in 425 Chinese patients with severe (n = 177) or mild (n = 248) disease...
  81. Ashton Chess J, Roussel J, Manez R, Ruiz C, Moreau A, Cozzi E, et al. Cellular participation in delayed xenograft rejection of hCD55 transgenic pig hearts by baboons. Xenotransplantation. 2003;10:446-53 pubmed
    ..Biopsies taken during DXR of human CD55 transgenic pig hearts by non-treated (n = 2), alpha-Gal immunoadsorbed (n = 2), or immunosuppressed (n = 9) baboons ..
  82. Poisson G, Chauve C, Chen X, Bergeron A. FragAnchor: a large-scale predictor of glycosylphosphatidylinositol anchors in eukaryote protein sequences by qualitative scoring. Genomics Proteomics Bioinformatics. 2007;5:121-30 pubmed
    ..Finally, by using qualitative scoring, the predictions combine both sensitivity and information content. The predictor is publicly available at [see text]. ..
  83. Terui Y, Sakurai T, Mishima Y, Mishima Y, Sugimura N, Sasaoka C, et al. Blockade of bulky lymphoma-associated CD55 expression by RNA interference overcomes resistance to complement-dependent cytotoxicity with rituximab. Cancer Sci. 2006;97:72-9 pubmed
    ..Fresh lymphoma cells were collected from 30 patients with non-Hodgkin's lymphoma, the expression of CD20 and CD55 was examined by flow cytometry, and complement-dependent cytotoxicity (CDC) assays were carried out...
  84. Shen P, Yue Y, Sun Q, Kasireddy N, Kim K, Park Y. Piceatannol extends the lifespan of Caenorhabditis elegans via DAF-16. Biofactors. 2017;43:379-387 pubmed publisher
    ..This study further indicated that lifespan extension and enhanced stress resistance induced by piceatannol requires DAF-16...
  85. Starodubtseva N, Kononikhin A, Bugrova A, Chagovets V, Indeykina M, Krokhina K, et al. Investigation of urine proteome of preterm newborns with respiratory pathologies. J Proteomics. 2016;149:31-37 pubmed publisher
    ..NCAM1, TRY1, DSG2), metabolism (LAMP1, AGRN, TPP1, GPX3, APOD, CUBN, IDH1), regulation of enzymatic activity (SERPINA4, VASN, GAPDH), inflammatory and stress response (CD55, CD 93, NGAL, HP, TNFR, LCN2, AGT, S100P, SERPINA1/C1/B1/F1).
  86. Li Y, Zhang G. Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans. Oncotarget. 2016;7:19185-92 pubmed publisher
    b>DAF-16, the C. elegans FOXO transcription factor, is an important determinant in aging and longevity. In this work, we manually curated FOXODB http://lyh.pkmu.cn/foxodb/, a database of FOXO direct targets. It now covers 208 genes...
  87. Pant A, Mishra V, Saikia S, Shukla V, Asthana J, Akhoon B, et al. Beta-caryophyllene modulates expression of stress response genes and mediates longevity in Caenorhabditis elegans. Exp Gerontol. 2014;57:81-95 pubmed publisher
    ..1, SKN-1 and DAF-16...
  88. Taylor C, Johnson P. Complement-binding proteins are strongly expressed by human preimplantation blastocysts and cumulus cells as well as gametes. Mol Hum Reprod. 1996;2:52-9 pubmed
    ..and cumulus cells were studied for expression of the complement-binding proteins CD46 (membrane cofactor protein), CD55 (decay accelerating factor) and CD59 (membrane attack complex inhibitory factor) as well as complement receptors ..
  89. Newcombe N, Johansson E, Au G, Lindberg A, Barry R, Shafren D. Enterovirus capsid interactions with decay-accelerating factor mediate lytic cell infection. J Virol. 2004;78:1431-9 pubmed
    ..displays a dual-receptor specificity as determined with a receptor complex consisting of decay-accelerating factor (DAF) and intercellular adhesion molecule 1 (ICAM-1)...