CD47

Summary

Gene Symbol: CD47
Description: CD47 molecule
Alias: IAP, MER6, OA3, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 glycoprotein, Rh-related antigen, antigen identified by monoclonal antibody 1D8, antigenic surface determinant protein OA3, integrin associated protein, integrin-associated protein, integrin-associated signal transducer
Species: human

Top Publications

  1. ncbi CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia
    V Mateo
    Laboratoire d allergie, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, 1560 rue Sherbrooke Est, Université de Montréal H2L 4M1, Quebec, Canada
    Nat Med 5:1277-84. 1999
  2. ncbi Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation
    J Chung
    Department of Biochemistry and Molecular Biophysics and Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 94:642-8. 1999
  3. ncbi C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma-chain-associated signaling pathway and by agglutination
    D Tulasne
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 98:3346-52. 2001
  4. ncbi Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation
    Laura Piccio
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 105:2421-7. 2005
  5. ncbi Integrin-associated protein (CD47) and its ligands
    E J Brown
    Program in Host Pathogen Interactions, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Cell Biol 11:130-5. 2001
  6. doi Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47
    Deborah Hatherley
    Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK
    Mol Cell 31:266-77. 2008
  7. pmc The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
    Stephen B Willingham
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:6662-7. 2012
  8. ncbi Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphaIIbbeta3 by its extracellular domain
    Tetsuro Takahiro Fujimoto
    Department of Hematology and Oncology, Division of Clinical Pharmacotherapeutics, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    J Biol Chem 278:26655-65. 2003
  9. ncbi Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin
    A G Gao
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:21-4. 1996
  10. doi Human thrombospondin's (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: a molecular modeling study
    Nicolas Floquet
    Institut des Biomolecules Max Mousseron, UMR 5247, CNRS Université Montpellier I Université Montpellier II, Faculte de Pharmacie, 15 rue Charles Flahault, B P 14 491, 34093 Montpellier Cedex 5, France
    Arch Biochem Biophys 478:103-9. 2008

Research Grants

  1. Heat Shock-Induced Apoptosis
    Shawn B Bratton; Fiscal Year: 2012
  2. Control of Trabecular Meshwork Cytoskeleton
    Donna M Peters; Fiscal Year: 2011
  3. Systematic analysis of cell death regulation in mosquitoes
    Lei Zhou; Fiscal Year: 2009
  4. Regulation of caspase-9
    Xiaolu Yang; Fiscal Year: 2013
  5. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
  6. REGULATION OF VIRUS-INDUCED PROGRAMMED CELL DEATH
    Paul D Friesen; Fiscal Year: 2010
  7. The role of XIAP during cold ischemia and kidney transplantation.
    ALKESH HARIHAR JANI; Fiscal Year: 2013
  8. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
  9. Development of a novel method for inhibiting diabetic retinopathy
    David R Clemmons; Fiscal Year: 2012
  10. Homing Receptor Determinants of HSC
    Irving L Weissman; Fiscal Year: 2013

Detail Information

Publications217 found, 100 shown here

  1. ncbi CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia
    V Mateo
    Laboratoire d allergie, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, 1560 rue Sherbrooke Est, Université de Montréal H2L 4M1, Quebec, Canada
    Nat Med 5:1277-84. 1999
    ..We report here that engagement of CD47, a newly described thrombospondin receptor, by immobilized monoclonal antibody against CD47 or by thrombospondin ..
  2. ncbi Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation
    J Chung
    Department of Biochemistry and Molecular Biophysics and Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 94:642-8. 1999
    Integrin-associated protein (IAP; or CD47) is a receptor for the cell binding domain (CBD) of thrombospondin-1 (TS1)...
  3. ncbi C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma-chain-associated signaling pathway and by agglutination
    D Tulasne
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 98:3346-52. 2001
    ..to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47. In this study, it was discovered that 4N1-1 or its derivative peptide, 4N1K, induces rapid phosphorylation of the ..
  4. ncbi Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation
    Laura Piccio
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 105:2421-7. 2005
    ..SIRPalpha binds CD47 and inhibits the function of macrophages, dendritic cells, and granulocytes, whereas SIRPbeta1 is an orphan ..
  5. ncbi Integrin-associated protein (CD47) and its ligands
    E J Brown
    Program in Host Pathogen Interactions, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Cell Biol 11:130-5. 2001
    Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, ..
  6. doi Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47
    Deborah Hatherley
    Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK
    Mol Cell 31:266-77. 2008
    b>CD47 is a widely distributed cell-surface protein that acts a marker of self through interactions of myeloid and neural cells...
  7. pmc The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
    Stephen B Willingham
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:6662-7. 2012
    b>CD47, a "don't eat me" signal for phagocytic cells, is expressed on the surface of all human solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue revealed that CD47 is overexpressed on cancer cells...
  8. ncbi Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphaIIbbeta3 by its extracellular domain
    Tetsuro Takahiro Fujimoto
    Department of Hematology and Oncology, Division of Clinical Pharmacotherapeutics, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    J Biol Chem 278:26655-65. 2003
    Integrin-associated protein (IAP/CD47) is a receptor for the C-terminal cell binding domain of thrombospondin (TS)...
  9. ncbi Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin
    A G Gao
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:21-4. 1996
    ..CBD of TS1 affinity label a 52-kDa cell surface glycoprotein, which we show is integrin-associated protein (IAP or CD47). IAP associates with alpha v beta 3 and thereby modulates the activity of several integrins...
  10. doi Human thrombospondin's (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: a molecular modeling study
    Nicolas Floquet
    Institut des Biomolecules Max Mousseron, UMR 5247, CNRS Université Montpellier I Université Montpellier II, Faculte de Pharmacie, 15 rue Charles Flahault, B P 14 491, 34093 Montpellier Cedex 5, France
    Arch Biochem Biophys 478:103-9. 2008
    ..We also suggest a common opening mechanism for proteins sharing the same fold as TSP-1. This work also suggests the usefulness of our approach in other topics in which predictions of protein-protein interactions are of importance...
  11. pmc Structure of signal-regulatory protein alpha: a link to antigen receptor evolution
    Deborah Hatherley
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Biol Chem 284:26613-9. 2009
    Signal-regulatory protein alpha (SIRPalpha) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self...
  12. pmc Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice
    May H Han
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 209:1325-34. 2012
    ..and proteomic data from pathologically similar multiple sclerosis (MS) lesions reveals down-regulation of CD47 at the messenger RNA level and low abundance at the protein level...
  13. ncbi Involvement of a CD47-dependent pathway in platelet adhesion on inflamed vascular endothelium under flow
    Patricia Lagadec
    Unité Institut National de la Santé et de la Recherche Médicale INSERM U343 et Laboratoire d Immunologie, Nice, France
    Blood 101:4836-43. 2003
    ..Using human platelets or platelets from wild-type and CD47-/- mice in whole blood, we demonstrated that at low shear rate, CD47 expressed on human and mouse platelets ..
  14. ncbi Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3
    J Chung
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:14740-6. 1997
    Integrin-associated protein (IAP or CD47) is a receptor for the cell/platelet-binding domain (CBD) of thrombospondin-1 (TS1), the most abundant protein of platelet alpha granules...
  15. pmc Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages
    Kentaro Ide
    Department of Surgery, Division of Frontier Medical Science, Hiroshima University, Hiroshima 734 8551, Japan
    Proc Natl Acad Sci U S A 104:5062-6. 2007
    ..regulatory protein (SIRP)alpha is a critical immune inhibitory receptor on macrophages, and its interaction with CD47, a ligand for SIRPalpha, prevents autologous phagocytosis...
  16. doi Selective control of SIRP-alpha-positive airway dendritic cell trafficking through CD47 is critical for the development of T(H)2-mediated allergic inflammation
    Marianne Raymond
    Immunoregulation Laboratory, Centre Hospitalier de L Universite de Montreal Research Center, Hopital Notre Dame, Montreal, Quebec, Canada
    J Allergy Clin Immunol 124:1333-42.e1. 2009
    ..Yet the identification and migratory properties of the DC subset that contributes to T(H)2-mediated responses remain to be clarified. CD47, a signal regulatory protein (SIRP)-alpha partner, reportedly governed skin DC migration.
  17. ncbi Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis
    Mohammad Salajegheh
    The Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, 75 Francis Street, Tower 5D, Boston, MA 02115, USA
    J Neuroimmunol 187:166-74. 2007
    The TSP1/CD36/CD47-complex is involved in T cell expansion and inflammatory responses to beta-amyloid, both relevant to IBM...
  18. doi Association study identifying polymorphisms in CD47 and other extracellular matrix pathway genes as putative prognostic markers for colorectal cancer
    Jesus Lascorz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany
    Int J Colorectal Dis 28:173-81. 2013
    ..We identified recently the extracellular matrix (ECM) receptor interaction pathway as a consistently overrepresented category among gene expression profiling studies on colorectal cancer (CRC) prognosis...
  19. ncbi Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains
    R A Rebres
    Program in Microbial Pathogenesis and Host Defense and Department of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 276:34607-16. 2001
    b>CD47 is a unique member of the Ig superfamily with a single extracellular Ig domain followed by a multiply membrane-spanning (MMS) domain with five transmembrane segments, implicated in both integrin-dependent and -independent signaling ..
  20. pmc Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47
    Sukhbir Kaur
    Laboratory of Pathology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:38923-32. 2010
    ..a more potent mechanism by which TSP1 inhibits VEGF receptor-2 (VEGFR2) activation through engaging its receptor CD47. CD47 ligation is known to inhibit downstream signaling targets of VEGFR2, including endothelial nitric-oxide ..
  21. pmc CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    Siddhartha Jaiswal
    Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 138:271-85. 2009
    Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPalpha, to inhibit phagocytosis of normal, healthy cells...
  22. ncbi Integrin-associated protein is a ligand for the P84 neural adhesion molecule
    P Jiang
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 274:559-62. 1999
    ..Here we report that integrin-associated protein (IAP/CD47) is a predominant binding partner of P84...
  23. ncbi Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane
    A L Wu
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell 4:619-25. 1999
    Integrin-associated protein (IAP, CD47) is a plasma membrane receptor for thrombospondins and signal regulatory proteins (SIRPs) that has an essential role in host defense through its association with integrins...
  24. pmc Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells
    Richard K Tsai
    Biophysical Engineering Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 180:989-1003. 2008
    ..cells or particles by macrophages is a rapid process that is inefficient when faced with "self" cells that display CD47-although signaling mechanisms in self-recognition have remained largely unknown...
  25. pmc Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro
    Michael Stefanidakis
    Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Blood 112:1280-9. 2008
    Leukocyte transendothelial migration (TEM) is a critical event during inflammation. CD47 has been implicated in myeloid cell migration across endothelium and epithelium...
  26. ncbi Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site
    Shyamsundar Subramanian
    Biophysical Engineering Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:1805-18. 2007
    Cell-cell interactions between ubiquitously expressed integrin-associated protein (CD47) and its counterreceptor signal regulatory protein (SIRPalpha) on phagocytes regulate a wide range of adhesive signaling processes, including the ..
  27. ncbi CD47 augments Fas/CD95-mediated apoptosis
    Partha P Manna
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:29637-44. 2005
    ..Jurkat T cells lacking CD47 (integrin-associated protein) are relatively resistant to Fas-mediated death but are efficiently killed by Fas ..
  28. ncbi The SIRP family of receptors and immune regulation
    A Neil Barclay
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 6:457-64. 2006
    ..In this Review, we describe recent studies defining the ligands of the SIRP-family members, with particular emphasis on relating the molecular interactions of these proteins to their role in immune-cell regulation...
  29. ncbi CD47 in the immune response: role of thrombospondin and SIRP-alpha reverse signaling
    Marika Sarfati
    Immunoregulation Laboratory, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hôpital Notre Dame Pavillon Mailloux, M4211K, 1560 Sherbrooke Est Montreal, QC H2L4M1, Canada
    Curr Drug Targets 9:842-50. 2008
    ..b>CD47 and its two ligands, i.e...
  30. pmc Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins
    E Brown
    Department of Medicine, Washington University, St Louis, Missouri 63110
    J Cell Biol 111:2785-94. 1990
    ..For this reason, we call it Integrin-associated Protein (IAP). We hypothesize that IAP may play a role in signal transduction for enhanced phagocytosis by Arg-Gly-Asp ligands.
  31. ncbi CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis
    Laurence Lamy
    Unité INSERM 576 et Laboratoire d Immunologie, 06202 Nice Cedex 3, France
    J Biol Chem 278:23915-21. 2003
    b>CD47 is a surface receptor that induces either coactivation or apoptosis in lymphocytes, depending on the ligand(s) bound...
  32. pmc Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding
    F P Lindberg
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 123:485-96. 1993
    b>Integrin Associated Protein (IAP) is a 50-kD membrane protein which copurifies with the integrin alpha v beta 3 from placenta and coimmunoprecipitates with beta 3 from platelets...
  33. pmc Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo
    Veronica Azcutia
    Department of Pathology, Center for Excellence in Vascular Biology, Boston, MA 02115, USA
    J Immunol 189:2553-62. 2012
    ..We previously reported that adhesive interactions between endothelial cell CD47 and leukocyte signal regulatory protein γ (SIRPγ) regulate human T cell TEM...
  34. ncbi Cholesterol-independent interactions with CD47 enhance alphavbeta3 avidity
    John F McDonald
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:17301-11. 2004
    Expression in OV10 cells of either wild-type CD47 or its extracellular IgV domain linked to a glycosylphosphatidylinositol anchor-(IgV-GPI) enhanced ligand-induced alpha(v)beta(3) activation as detected by the binding of LIBS1 and LIBS6 ..
  35. doi MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47
    Andreas Junker
    Institute for Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany
    Brain 132:3342-52. 2009
    ..This converged on CD47, which functions as a 'don't eat me' signal inhibiting macrophage activity...
  36. ncbi Mechanism of CD47-induced alpha4beta1 integrin activation and adhesion in sickle reticulocytes
    Julia E Brittain
    Department of Pharmacology, University of North Carolina at Chapel Hill, 27599 7365, USA
    J Biol Chem 279:42393-402. 2004
    We recently reported that CD47 (integrin-associated protein) on sickle red blood cells (SS RBCs) activates G-protein-dependent signaling, which promotes cell adhesion to immobilized thrombospondin (TSP) under relevant shear stress...
  37. doi Neuronal regulation of immune responses in the central nervous system
    Li Tian
    Neuroscience Center, University of Helsinki, Viikinkaari 4, FIN 00014, Helsinki, Finland
    Trends Immunol 30:91-9. 2009
    ..In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity...
  38. ncbi Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47
    Isabelle Mouro-Chanteloup
    Institut National de la Santé et de la Recherche Médicale INSERM U76, Institut National de la Transfusion Sanguine, Paris, France
    Blood 101:338-44. 2003
    ..the linking protein(s) between the red cell skeleton and the Rh complex, we analyzed the expression of Rh, RhAG, CD47, LW, and glycophorin B proteins in red cells from patients with hereditary spherocytosis associated with complete ..
  39. ncbi Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization
    Véronique Mateo
    Centre de Recherche du Centre Hospitalier Université Montreal, Laboratoire d Immunorégulation, Universite de Montreal, Canada
    Blood 100:2882-90. 2002
    Dying cells, apoptotic or necrotic, are swiftly eliminated by professional phagocytes. We previously reported that CD47 engagement by CD47 mAb or thrombospondin induced caspase-independent cell death of chronic lymphocytic leukemic B ..
  40. ncbi Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation
    S Latour
    McGill Cancer Center, McGill University and Institut de Recherches Cliniques, Montreal, Quebec, Canada
    J Immunol 167:2547-54. 2001
    ..In this study, we first show that CD47/integrin-associated protein, a ubiquitous multispan transmembrane protein highly expressed on T cells, interacts ..
  41. ncbi Regulation of integrin function by CD47 ligands. Differential effects on alpha vbeta 3 and alpha 4beta1 integrin-mediated adhesion
    Heba O Barazi
    Laboratory of Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:42859-66. 2002
    We examined the regulation of alpha4beta1 integrin function in melanoma cells and T cells by ligands of CD47. A CD47 antibody (B6H12) that inhibited alphavbeta3-mediated adhesion of melanoma cells induced by CD47-binding peptides from ..
  42. ncbi Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions
    Anna M Moralez
    Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill, NC 27599, USA
    J Cell Physiol 203:328-34. 2005
    ..by which IGFBP-5 binding to TS-1 inhibited cellular responses to TS-1 plus IGF-I, TS-1 binding to integrin associated protein (IAP) was assessed. The addition of IGFBP-5 (1.0 microg/ml) inhibited TS-1-IAP association...
  43. ncbi Alpha-Pal/NRF-1 regulates the promoter of the human integrin-associated protein/CD47 gene
    Wen Teng Chang
    Institute of Basic Medical Sciences, National Cheng Kung University, Medical College, Tainan 701, Taiwan
    J Biol Chem 279:14542-50. 2004
    Integrin-associated protein (IAP or CD47) is expressed in a variety of tissues, including the nervous system and immune system...
  44. ncbi SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages
    J F Timms
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Biol 9:927-30. 1999
    ..Other inhibitory immunoreceptors might have similar scaffold-like functions...
  45. pmc An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction
    L Erb
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Cell Biol 153:491-501. 2001
    ..by antibodies against alpha(V)beta(3)/beta(5) integrins and the integrin-associated thrombospondin receptor, CD47. Immunofluorescence of cells transfected with epitope-tagged P2Y(2)Rs indicated that alpha(V) integrins colocalized ..
  46. ncbi Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells
    Kris Noel Dahl
    Department of Chemical and Biomolecular Engineering and School of Engineering and Applied Science, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 103:1131-6. 2004
    The reduction in expression of the integral membrane protein CD47 in human red blood cells (RBCs) deficient in protein 4.2 suggests that protein 4.2 may mediate a linkage of CD47 to the membrane skeleton...
  47. ncbi CD47 expression on T cell is a self-control negative regulator of type 1 immune response
    Salim Bouguermouh
    Immunoregulation, Centre Hospitalier de l Universite de Montreal, Research Center, Hospital Notre Dame, Montreal, Quebec, Canada
    J Immunol 180:8073-82. 2008
    ..Yet, the control of Th1 polarization by T cell surface molecules remains ill-defined. We here report that CD47 expression on T cells serves as a self-control mechanism to negatively regulate type 1 cellular and humoral immune ..
  48. ncbi Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling
    Shyamsundar Subramanian
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood Cells Mol Dis 36:364-72. 2006
    b>Integrin Associated Protein (IAP, CD47) is a ubiquitous integral membrane protein implicated in processes (in mice) that range from inhibiting clearance by phagocytes [Oldenborg et al., Science 2000; Gardai et al...
  49. ncbi Evidence that muscarinic receptors in islet cells are not coupled functionally to adenylate cyclase through the inhibitory guanine nucleotide binding protein (Ni)
    M Dunlop
    University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Victoria, Australia
    Horm Metab Res 20:150-3. 1988
    ..adenylate cyclase (Ni) was investigated by the use of the Bordetella pertussis exotoxin, islet activating protein (IAP)...
  50. pmc Six areas lead national early immunization drive
    D R Woods
    Division of Immunization, Centers for Disease Control, Atlanta, GA 30333
    Public Health Rep 107:252-6. 1992
    ..The community "Immunization Action Plans" (IAP) are one of several Federal, State, and local responses to an outbreak of measles that produced 27,600 cases and 89 ..
  51. pmc Sensitivity of G-protein involved in endothelin-1-induced Ca2+ influx to pertussis toxin in porcine endothelial cells in situ
    H Aoki
    Division of Molecular Cardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 111:989-96. 1994
    ..4. Pertussis toxin (IAP) markedly inhibited the extracellular Ca2+-dependent elevation of [Ca2+]j, but had no effect on the extracellular ..
  52. ncbi Phospholipase A2-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulation
    T Nakajima
    Division of Environmental Health Research, Osaka Prefectural Institute of Public Health, 69 3, 1 chome, 537 0025, Osaka, Japan
    Int J Biochem Cell Biol 32:779-87. 2000
    ..macrophages: p-bromophenacyl bromide (pBPB) and mepacrine for PLA(2); islet-activating protein (IAP) for G-protein; H-7 for protein kinase C (PKC); AA861 for 5-lipoxygenase (5-LO); indomethacin for cyclo-oxygenase (..
  53. ncbi Cycloheximide increases endogenous retroviral RNA levels in murine liver and lung
    G Manenti
    Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan. Italy
    Tumori 75:217-21. 1989
    The expression of moloney murine leukemia virus (Mo-MuLV), intracisternal A particle (IAP), virus-like 30S sequence (VL30), early transposon (ET) endogenous retroviral sequences was analysed in the liver of untreated C3Hf, C57BL/6J and ..
  54. ncbi Indoor air quality for poor families: new evidence from Bangladesh
    S DasGupta
    Development Research Group, World Bank, Washington, DC 20433, USA
    Indoor Air 16:426-44. 2006
    ..This paper provides a detailed analysis of the implications for indoor air pollution (IAP), drawing on new 24-h monitoring data for respirable airborne particulates (PM10)...
  55. ncbi Pharmacist and physician satisfaction and rates of switching to preferred medications associated with an instant prior authorization program for proton pump inhibitors in the North Carolina Medicaid program
    Julie C Jacobson Vann
    School of Nursing, Health Care Systems, University of North Carolina at Chapel Hill, Carrington Hall, CB 7460, Chapel Hill, NC 27599 7460, USA
    J Manag Care Pharm 16:250-63. 2010
    ..Preferred PPIs included generic omeprazole and Prilosec OTC. This instant approval process (IAP) was expected to impose less administrative burden than is typically associated with PA programs by permitting ..
  56. ncbi Comparison of intrabrachial and finger blood pressure in healthy elderly volunteers
    G A Rongen
    Department of Medicine, University Hospital, Nijmegen, The Netherlands
    Am J Hypertens 8:237-48. 1995
    This study was performed to compare continuous Finapres (FIN) and intrabrachial (IAP) blood pressure in healthy elderly volunteers...
  57. ncbi Hormonal influence on lipid-protein interactions in biological membranes. Lactation effects on alkaline phosphatase activity and intestinal brush border membrane properties in rat
    A S Molina
    , , Universidad Nacional de San Luis, Argentina
    Horm Metab Res 29:159-63. 1997
    ..Our objective was to study the intestinal alkaline phosphatase (IAP) activity, lipid composition and fluidity of the proximal small intestine brush border membranes under the ..
  58. ncbi Sensitive detection of two IgG Fc receptors of mouse macrophages by chemiluminescence analysis
    T Majima
    Department of Bacteriology, Tohoku University School of Medicine, Sendai
    Immunopharmacol Immunotoxicol 11:289-307. 1989
    ..alpha A/D to the resident M phi s in vitro and the specific activation of spleen M phi FcRII by iv injection of IAP (Immunosuppressive acidic protein) into mice...
  59. pmc The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells
    X Q Wang
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Biol Cell 9:865-74. 1998
    ..Integrin-associated protein (IAP or CD47) is a receptor for the thrombospondin-1 carboxyl-terminal cell-binding domain and binds the agonist peptide 4N1K (..
  60. ncbi Comparison of different methods for measuring intra-abdominal pressure
    F F Gudmundsson
    Surgical Research Laboratory, Haukeland University Hospital, University of Bergen, 5021 Bergen, Norway
    Intensive Care Med 28:509-14. 2002
    Intra-abdominal pressure (IAP) can be measured in different ways but is usually measured indirectly via the urinary bladder...
  61. pmc Thrombospondin-1/CD47 blockade following ischemia-reperfusion injury is tissue protective
    Justin B Maxhimer
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Plast Reconstr Surg 124:1880-9. 2009
    ..following ischemia-reperfusion injury and limits nitric oxide signaling by engaging its cell surface receptor CD47. In this article, the authors examine whether postinjury blocking of this inhibitory signal can protect from ..
  62. ncbi Significance of increased neutrophils in patients with advanced colorectal cancer
    A Satomi
    Second Department of Surgery, Saitama Medical School, Japan
    Acta Oncol 34:69-73. 1995
    ..The ability to produce active oxygen and phagocytosis of neutrophils, G-CSF, sIL-2R and IAP (immunosuppressive acidic protein) were also measured...
  63. ncbi The reliability of noninvasive continuous finger blood pressure measurement in patients with both hypertension and vascular disease
    W J Bos
    Department of Internal Medicine, University of Amsterdam, The Netherlands
    Am J Hypertens 5:529-35. 1992
    ..We therefore compared Finapres blood pressure (FINAP) with intrabrachial blood pressure (IAP) responses to the Valsalva maneuver and arising in 12 patients in whom the peripheral circulation was expected to ..
  64. ncbi Early-onset group B streptococcal disease in the era of maternal screening
    Karen M Puopolo
    Department of Newborn Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 115:1240-6. 2005
    With the widespread implementation of intrapartum antibiotic prophylaxis (IAP), the rate of early-onset neonatal sepsis and meningitis caused by Streptococcus agalactiae (group B streptococcus [GBS]) has decreased dramatically, ..
  65. ncbi Correlations between cardiac output, stroke volume, central venous pressure, intra-abdominal pressure and total circulating blood volume in resuscitation of major burns
    Markus V Küntscher
    Department for Hand, Plastic and Reconstructive Surgery, Burn Center, BG, Trauma Center Ludwigshafen, Plastic and Hand Surgery, The University of Heidelberg, Berlin, Germany
    Resuscitation 70:37-43. 2006
    ..between cardiac index (CI), stroke volume index (SVI), central venous pressure (CVP), intra-abdominal pressure (IAP) and total circulating blood volume index (TBVI) during resuscitation of major burns...
  66. pmc Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathways
    Mark S Filla
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Invest Ophthalmol Vis Sci 50:5723-31. 2009
    ..CLANs form in glaucomatous and steroid-treated TM cells, which may contribute to reducing outflow facility through the TM...
  67. pmc Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses
    Jeff S Isenberg
    Laboratory of Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 284:1116-25. 2009
    Thrombospondin-1 regulates nitric oxide (NO) signaling in vascular cells via CD47. Because CD47 binding motifs are conserved in the C-terminal signature domains of all five thrombospondins and indirect evidence has implied CD47 ..
  68. ncbi [Abdominal compartment syndrome (ACS) after abdominal aortic aneurysm (AAA) open repair]
    Guido Bajardi
    Cattedra di Chirurgia Vascolare, Universita degli Studi di Palermo
    Ann Ital Chir 80:369-74. 2009
    ....
  69. ncbi Trends in sepsis-related neonatal mortality in the United States, 1985-1998
    Susan L Lukacs
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    Pediatr Infect Dis J 23:599-603. 2004
    ..In the 1990s, intrapartum antibiotic prophylaxis (IAP) was recommended to prevent maternal-infant transmission of group B Streptococcus (GBS), a leading cause of sepsis ..
  70. pmc Selective expression of intracisternal A-particle genes in established mouse plasmacytomas
    K K Lueders
    Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892
    Mol Cell Biol 13:7439-46. 1993
    Mouse plasmacytomas generally express higher levels of RNA transcripts from endogenous intracisternal A-particle (IAP) proviral elements than do lipopolysaccharide-stimulated normal lymphocytes...
  71. ncbi Serum soluble interleukin-2 receptor in colorectal cancer
    S Murakami
    Second Department of Surgery, Saitama Medical School, Japan
    Acta Oncol 33:19-21. 1994
    ..cancer, and correlated with various factors as stage, lymph node metastasis, liver metastasis, grade, serum CEA and IAP (immunosuppressive acidic protein)...
  72. ncbi The role of the intracarotid amobarbital procedure in evaluation of patients for epilepsy surgery
    D C Spencer
    Department of Neurology, Oregon Health Sciences University, Portland, USA
    Epilepsia 41:320-5. 2000
    To examine the role of the intracarotid amobarbital procedure (IAP) in the presurgical evaluation of patients with medically refractory localization-related epilepsy.
  73. ncbi Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity
    Alexandra Giatromanolaki
    Tumour and Angiogenesis Research Group, Departments of Pathology, Internal Medicine, and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Semin Oncol 29:14-21. 2002
    ..However, the mechanism of such selective action is poorly understood. Intestinal-type alkaline phosphatase (IAP) is a major isoenzyme involved in the hydrolysis of amifostine (WR-2721) to its active thiol form WR-I065...
  74. doi Effect of elevated intra-abdominal pressure on portal vein and superior mesenteric artery blood flow in a rat
    Jorge Mogilner
    Department of Pediatric Surgery, Bnai Zion Medical Center, Israel
    J Laparoendosc Adv Surg Tech A 19:S59-62. 2009
    ..It should be emphasized that elevated intra-abdominal pressure (IAP) may reduce hepatic and portal blood flow and thus may cause histologic liver damage...
  75. ncbi Differential effects of retroviral long terminal repeats on interleukin-3 gene expression and autocrine transformation
    X Y Wang
    Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina 27858, USA
    Leukemia 11:1711-25. 1997
    Previously we documented the transposition of an intracisternal A particle (IAP) provirus to the interleukin 3 (IL-3) locus which resulted in autocrine transformation...
  76. doi Changes in intra-abdominal pressure and spontaneous breath volume by magnitude of lifting effort: highly trained athletes versus healthy men
    Masashi Kawabata
    National Institute of Fitness and Sports, 1 Shiromizu, Kanoya, Kagoshima 891 2393, Japan
    Eur J Appl Physiol 109:279-86. 2010
    Intra-abdominal pressure (IAP) is closely related to breathing behavior during lifting. Abdominal muscles contribute to both IAP development and respiratory function...
  77. ncbi Interaction of guanine-nucleotide-binding regulatory proteins with chemotactic peptide receptors in differentiated human leukemic HL-60 cells
    M Tohkin
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    Eur J Biochem 195:527-33. 1991
    ..regulatory proteins (G proteins) serving as the substrate for pertussis toxin (islet-activating protein; IAP) were extracted from cell membranes then reconstituted into phospholipid vesicles...
  78. ncbi Can the Wada test evaluate mesial temporal function? A SPECT study
    X Setoain
    Department of Nuclear Medicine, Hospital Clinic of Barcelona, University of Barcelona, Spain
    Neurology 62:2241-6. 2004
    To assess the value of SPECT during intracarotid amobarbital procedure (IAP) to discriminate which patients performed the test with the hippocampus inactivated and correlate it with the risk of amnesia after anterior temporal lobectomy (..
  79. doi Influence of increased intra-abdominal pressure on fluid responsiveness predicted by pulse pressure variation and stroke volume variation in a porcine model
    Jochen Renner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Crit Care Med 37:650-8. 2009
    ..The influence of increased intra-abdominal pressure (IAP) on the predictive ability of these variables is currently under debate...
  80. pmc Amsacta moorei Entomopoxvirus inhibitor of apoptosis suppresses cell death by binding Grim and Hid
    Qianjun Li
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Box 100266, Gainesville, FL 32610 0266, USA
    J Virol 79:3684-91. 2005
    Inhibitor of apoptosis (iap) genes have been identified in the genomes of two independent families of insect viruses, the Baculoviridae and the Entomopoxvirinae...
  81. pmc Intra-abdominal pressure alterations after large pancreatic pseudocyst transcutaneous drainage
    Theodossis S Papavramidis
    1st Propedeutic Department of Surgery, AHEPA University Hospital, Aristotle s University of Thessaloniki, Macedonia, Greece
    BMC Gastroenterol 9:42. 2009
    ..Aims of the present study were to evaluate the intra-abdominal pressure (IAP) induced by large pancreatic pseudocysts and to examine the effect of their transcutaneous drainage on IAP.
  82. pmc Comparison of virulence plasmids among Clostridium perfringens type E isolates
    Jihong Li
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Infect Immun 75:1811-9. 2007
    Clostridium perfringens type E isolates produce iota-toxin, which is encoded by iap and ibp genes...
  83. ncbi Interpretation of EMG changes with fatigue: facts, pitfalls, and fallacies
    N A Dimitrova
    Centre of Biomedical Engineering, Bulgarian Academy of Sciences, Acad G Bonchev Str, Bl 105, 1113, Sofia, Bulgaria
    J Electromyogr Kinesiol 13:13-36. 2003
    ..for pitfalls and fallacies in analysis of experimental results if changes in intracellular action potential (IAP), i.e. in peripheral factors of muscle fatigue, were not taken into consideration...
  84. ncbi [Effects of early goal-directed fluid therapy on intra-abdominal hypertension and multiple organ dysfunction in patients with severe acute pancreatitis.]
    Zhi Yong Yang
    Pancreatic Surgery, Union Hospital, Affiliated Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Wai Ke Za Zhi 47:1450-4. 2009
    ..To observe the effects of early goal-directed fluid therapy with hydroxyethyl starch 130/0.4 on intra-abdominal hypertension (IAH), multiple organ dysfunction and fluid balance in severe acute pancreatitis (SAP) patients...
  85. ncbi Evaluation of a method for measuring tissue non-specific alkaline phosphatase activity in healthy subjects
    Makoto Matsushita
    Department of Clinical Chemistry, Saitama Prefectural University, 820 Sannomiya, Koshigaya 343 8540, Japan
    Ann Clin Biochem 44:544-8. 2007
    Intestinal alkaline phosphatase (IAP) isozymes in the healthy human serum samples appears in two isoforms: normal-molecular-weight IAP (NIAP) and high-molecular-weight IAP (HIAP)...
  86. ncbi Continuous negative abdominal pressure device to treat pseudotumor cerebri
    H J Sugerman
    Department of Surgery, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia, USA
    Int J Obes Relat Metab Disord 25:486-90. 2001
    To study the effects of an externally applied negative abdominal pressure device designed to lower the effects of intra-abdominal pressure (IAP) on headaches and pulsatile tinnitus in severely obese women with pseudotumor cerebri (PTC).
  87. doi Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)
    John W Blankenship
    Department of Protein Engineering, Genentech, Inc, 1 DNA Way, M S 40, South San Francisco, CA 94080, USA
    Biochem J 417:149-60. 2009
    A family of anti-apoptotic regulators known as IAP (inhibitor of apoptosis) proteins interact with multiple cellular partners and inhibit apoptosis induced by a variety of stimuli...
  88. pmc Pilot testing of WHO child growth standards in Chandigarh: implications for India's child health programmes
    Shankar Prinja
    Postgraduate Institute of Medical Education and Research, School of Public Health, Chandigarh, India
    Bull World Health Organ 87:116-22. 2009
    To compare the prevalence of underweight as calculated from Indian Academy of Paediatrics (IAP) growth curves (based on the Harvard scale) and the new WHO Child Growth Standards.
  89. ncbi Health benefits from reducing indoor air pollution from household solid fuel use in China--three abatement scenarios
    Heidi Elizabeth Staff Mestl
    Center for International Climate and Environmental Research, P O Box 1129 Blindern, N 0318 Oslo, Norway
    Environ Int 33:831-40. 2007
    According to the World Health Organization (WHO), indoor air pollution (IAP) from the use of solid fuels in households in the developing world is responsible for more than 1.6 million premature deaths each year, whereof 0...
  90. doi Effects of norepinephrine during intra-abdominal hypertension on renal blood flow in bacteremic dogs
    Zhi Y Peng
    Chinese University of Hong Kong, Hong Kong, China
    Crit Care Med 36:834-41. 2008
    ..The effects of intra-abdominal pressure (IAP), followed by restoration of APP with norepinephrine, on renal blood flow were determined.
  91. ncbi Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons
    Hiroshi Ohnishi
    Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371 8512, Japan
    J Neurosci 25:2702-11. 2005
    ..protein tyrosine phosphatase (SHP) substrate-1 (SHPS-1) and its ligand cluster of differentiation 47 (CD47), both of which are members of the Ig superfamily of proteins, are thought to constitute an intercellular ..
  92. doi Activation of CD47 receptors causes proliferation of human astrocytoma but not normal astrocytes via an Akt-dependent pathway
    Emilie Sick
    Universite de Strasbourg, CNRS UMR 7213 Pharmacologie, Faculte de Pharmacie, 74 rte du Rhin, Illkirch, France
    Glia 59:308-19. 2011
    b>CD47 is a membrane receptor that plays pivotal roles in many pathophysiological processes, including infection, inflammation, cell spreading, proliferation, and apoptosis...
  93. ncbi Intestinal alkaline phosphatase secretion in oil-fed rats
    Jyotdeep Kaur
    Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India
    Dig Dis Sci 52:665-70. 2007
    Oil feeding is known to increase the secretion of intestinal alkaline phosphatase (IAP) into serum and this phenomenon is shown to be mediated by surfactant-like particles...
  94. ncbi Laparoscopic spray application of fibrin sealant effects on hemodynamics and spray efficiency at various application pressures and distances
    K T Druckrey-Fiskaaen
    Department of Visceral, Transplantation, Thoracic, and Vascular Surgery, Universitat Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany
    Surg Endosc 21:1750-9. 2007
    Laparoscopic resections of parenchymal organs are increasingly performed. However, little is known about the effects of laparoscopic fibrin sealant spray applications on intraabdominal pressure (IAP) and hemodynamics.
  95. ncbi The inhibitors of apoptosis of Epiphyas postvittana nucleopolyhedrovirus
    T Maguire
    Department of Microbiology, School of Medical Sciences, University of Otago, PO Box 56, Dunedin, New Zealand
    J Gen Virol 81:2803-11. 2000
    ..apoptosis genes (iaps) in the genome of Epiphyas postvittana nucleopolyhedrovirus (EppoMNPV) that are homologous to iap-1, iap-2, iap-3 and iap-4 genes of other baculoviruses have been identified...
  96. ncbi Adverse effects of pneumoperitoneum on renal function: involvement of the endothelin and nitric oxide systems
    Zaid Abassi
    Department of Physiology and Biophysics, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Isarel Institute of Technology, Haifa, 31096, Israel
    Am J Physiol Regul Integr Comp Physiol 294:R842-50. 2008
    Increased intra-abdominal pressure (IAP) during laparoscopy adversely affects kidney function. The mechanism underlying this phenomenon is largely unknown...
  97. ncbi Direct comparison of local cerebral blood flow rates measured by MRI arterial spin-tagging and quantitative autoradiography in a rat model of experimental cerebral ischemia
    James R Ewing
    Department of Neurology and Center for Stroke Research, Henry Ford Hospital and Health Science Center, Detroit, Michigan 48202, USA
    J Cereb Blood Flow Metab 23:198-209. 2003
    ..using two different magnetic resonance imaging (MRI) arterial spin-tagging (AST) methods and 14C-iodoantipyrine (IAP)-quantitative autoradiography (QAR), a standard but terminal technique used for imaging and quantitating CBF, and ..
  98. pmc CD47 gene knockout protects against transient focal cerebral ischemia in mice
    Guang Jin
    Department of Radiology and Neurology, Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Massachusetts 02129, USA
    Exp Neurol 217:165-70. 2009
    b>CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels. The present study was performed to determine whether absence of the CD47 gene decreases focal ischemic brain damage...
  99. doi Effect of elevated intra-abdominal pressure and 100% oxygen on superior mesenteric artery blood flow and enterocyte turnover in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery B, Bnai Zion Medical Center, 47 Golomb St, P O B 4940, 31048, Haifa, Israel
    Pediatr Surg Int 24:1347-53. 2008
    Elevated intra-abdominal pressure (IAP) has been shown to reduce mesenteric blood flow and cause intestinal damage...
  100. pmc Gene silencing of CD47 and antibody ligation of thrombospondin-1 enhance ischemic tissue survival in a porcine model: implications for human disease
    Jeff S Isenberg
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Ann Surg 247:860-8. 2008
    ..Recently, we reported that the secreted protein thrombospondin-1 (TSP1), through its cell surface receptor CD47, limits the ability of NO to relax and dilate blood vessels and thus decreases tissue perfusion...
  101. pmc Situational analysis of household energy and biomass use and associated health burden of indoor air pollution and mitigation efforts in Pakistan
    Zafar Fatmi
    Division of Environmental Health Sciences, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Int J Environ Res Public Health 7:2940-52. 2010
    ..the indoor environment in countries where it is in common use, contributing significantly to indoor air pollution (IAP)...

Research Grants65

  1. Heat Shock-Induced Apoptosis
    Shawn B Bratton; Fiscal Year: 2012
    ..MOMP is critical for cell death most likely because it facilitates the release of inhibitor of apoptosis (IAP) antagonists, which in turn promote caspase activity...
  2. Control of Trabecular Meshwork Cytoskeleton
    Donna M Peters; Fiscal Year: 2011
    ..of the integrin signaling pathways that are unregulated by steroid treatment and activated by both integrin and CD47 in TM cells in culture...
  3. Systematic analysis of cell death regulation in mosquitoes
    Lei Zhou; Fiscal Year: 2009
    ..e. the *Reaper/Hid/Grim -like IAP-antagonists, in the annotated mosquito genomes...
  4. Regulation of caspase-9
    Xiaolu Yang; Fiscal Year: 2013
    ..This inhibitory effect of IAPs is countered during apoptosis by mitochondrial IAP-binding proteins. Compounds mimicking the effect of IAP-binding proteins show promise in tumor therapy...
  5. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..The Inhibitor of Apoptosis (IAP), survivin, is not detected in normal urothelium and its expression in bladder cancer correlates with poor ..
  6. REGULATION OF VIRUS-INDUCED PROGRAMMED CELL DEATH
    Paul D Friesen; Fiscal Year: 2010
    ..a cell executes apoptosis through activation of their caspases and how baculovirus-encoded inhibitor-of-apoptosis IAP and P49 neutralize these death proteases...
  7. The role of XIAP during cold ischemia and kidney transplantation.
    ALKESH HARIHAR JANI; Fiscal Year: 2013
    ..XIAP belongs to the Inhibitor of Apoptosis Protein (IAP) family, whose members bind and inhibit caspases 3, 7, and/or 9...
  8. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..In this amended renewal application, Project 1 will study the contribution of endothelial CD47 and its ligands Signal Regulatory Proteins and thrombospondin, as well as leukocyte CD47 dependent regulation of ..
  9. Development of a novel method for inhibiting diabetic retinopathy
    David R Clemmons; Fiscal Year: 2012
    ..be activated in response to hyperglycemia plus IGF-I, it must associate with a membrane protein termed integrin associated protein (IAP)...
  10. Homing Receptor Determinants of HSC
    Irving L Weissman; Fiscal Year: 2013
    ..to and from BM sites under steady state conditions;2) To establish whether blockade of macrophage phagocytosis by CD47 enables mouse and human HSC homing to hematopoietic microenvironments and 3) To isolate and characterize HSC-..
  11. Molecular Targeting of the Survivin Pathway in Cancer
    Dario C Altieri; Fiscal Year: 2010
    Survivin is a member of the Inhibitor of Apoptosis (IAP) gene family that has attracted attention for its dual role in cell division and cytoprotection, and its overexpression in nearly every human tumor...
  12. CYSTEINE PROTEASES IN APOPTOSIS AND CANCER
    EMAD ALNEMRI; Fiscal Year: 2005
    ..also regulated by a balance between the amount of inhibitor of apoptosis proteins (IAPs) and proteins that disrupts IAP-caspase interaction (IAP-inhibitors), such as mammalian Smac/DIABLO and drosophila Reaper, Hid, and Grim...
  13. Development Therapy for Metastatic Colorectal Cancer
    Janet Houghton; Fiscal Year: 2007
    ..Preliminary studies also demonstrate sites of interaction in addition to Fas that involve caspases, the IAP protein survivin, and p21Cip1...
  14. Role of Beta 3 Integrin in Skeletal Metastasis
    Katherine Weilbaecher; Fiscal Year: 2009
    ..integrin expression on different tissues and [unreadable]3 integrin regulation by 2) P2Y12 and 3) Integrin associated protein/CD47 will regulate tumor metastasis to bone. Thus, our Specific Aims are: 1...
  15. TSP-1 and ROS: CD47 and SIRP-alpha as Mediators of Vascular Dysfunction
    Patrick J Pagano; Fiscal Year: 2013
    ..We reported that TSP1, via its cognate receptor CD47, inhibits vasodilatation, however the exact mechanism remain unclear...
  16. Development of Hardware and Software for Clinical MEG
    Norman Tepley; Fiscal Year: 2010
    ..functional MEG language and memory imaging as a noninvasive alternative to the intracarotid amobarbital procedure (IAP, Wada test) by demonstrating that the spatial and temporal resolution provided by MEG is necessary to image the ..
  17. IAP Family Proteins and Cancer
    Guy S Salvesen; Fiscal Year: 2013
    ..b>IAP family members XIAP, c-IAP1, and c-IAP2 are E3 ligases, catalyzing formation of polyubiquitin chains on substrates ..
  18. ADPKD: Understanding mechanisms, Discovering treatments.
    Xiaogang Li; Fiscal Year: 2013
    ..The inhibitor of apoptosis (IAP) antagonist, Smac-mimetic, is able to target the above TNF??-mediated complexes to induce cancer cell death...
  19. Design of Orally Bioavailable IAP Antagonists for Cancer Treatment
    Shaomeng Wang; Fiscal Year: 2013
    ..Among these IAP proteins, cellular IAP-1 (cIAP-1) and cellular IAP-2 (cIAP-2) play critical roles in the regulation of death-..
  20. INTEGRIN ASSOCIATED PROTEIN/CD47 IS A THROMBOSPONDIN RECEPTOR
    William A Frazier; Fiscal Year: 2012
    ..During the preceding grant period we have discovered that TSP1 and CD47 (integrin-associated protein) regulate the dynamic range of nitric oxide (NO) signaling in vascular cells...
  21. Role of Integrins/ECM in Controlling IGF-I Actions
    David Robert Clemmons; Fiscal Year: 2013
    ..The physiologic significance of the SHPS-l-integrin associated protein (lAP) interaction will be defined in several cell types by disrupting this interaction and determining ..
  22. Signal Transduction Pathways in CD30-positive Lymphomas
    Colin S Duckett; Fiscal Year: 2013
    ..expand on some provocative unpublished data to answer the crucial question: what are the targets of the CD30:TRAF:c-IAP signaling complex? In Aim 2 we will take biochemical and imaging approaches to ask: how do the TRAFs, c-IAPs and ..
  23. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
    ..In Avy mice that have an intracisternal A particle (IAP) in their agouti gene, exposure to a maternal diet-enriched in genistein or methyl- donors results in methylation ..
  24. EVOLVING HIGH AFFINITY SIRPa MUTANTS TO STIMULATE PHAGOCYTOSIS OF TUMOR CELLS
    KIPP A WEISKOPF; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): CD47 is a cell-surface molecule that acts as a "don't eat me" signal to the host immune system...
  25. Platelet TSP1 Mediates Vascular Disease and pulmonary hypertension in Sickle Cell
    Enrico M Novelli; Fiscal Year: 2013
    ..TSP1) was found to potently inhibits physiologic NO signaling, via binding to the cell surface receptor CD47. Preliminary data from Dr...
  26. Design of Bivalent SMAC Mimetics
    Shaomeng Wang; Fiscal Year: 2013
    ..b>IAP proteins represent new and highly promising molecular targets for anti-cancer drug design aiming at overcoming ..
  27. Anti-CD47 mAb Therapy to Improve Kidney Transplantation
    PAMELA ANN TOY-MANNING; Fiscal Year: 2011
    ..The founders of Vasculox have discovered a ligand-receptor system, thrombospondin-1 (TSP1) and CD47, that continually opposes the action of beneficial NO in all vascular cells...
  28. Evaluating the role of Thrombospondin-1-CD47 mediated nitric oxide signaling in t
    Sarah Amend; Fiscal Year: 2013
    ..There is evidence that TSP1 regulates nitric oxie (NO) signaling via two of its ligands, CD36 and CD47. Tonic levels of NO are critical for cell survival...
  29. Anti-CD47 mAb Therapy to Improve Kidney Transplantation
    PAMELA ANN TOY-MANNING; Fiscal Year: 2013
    ..However, the founders of Vasculox discovered that thrombospondin-1 (TSP1) binding to its receptor, CD47, limits NO signaling throughout the vascular system thereby worsening IRI...
  30. Treatment of Transplant Reperfusion with CD47 antibody
    PAMELA ANN TOY-MANNING; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vasculox, Inc. is developing a humanized anti-CD47 mAb for reducing ischemia-reperfusion injury (IRI) in organ transplantation...
  31. Role of Beta 3 Integrin in Skeletal Metastasis
    KATHERINE NELSON WEILBAECHER; Fiscal Year: 2013
    ..roles of the [unreadable]3 integrin activating receptor, P2Y12, and a [unreadable]3-integrin stimulating protein, CD47, on platelet and osteoclast function and during bone metastasis...
  32. Determination of a Mechanism for the Thrombocytopenia of WAS
    Ted S Strom; Fiscal Year: 2010
    ..In a related animal model (CD47 deficiency), rapid phagocytosis of platelets and red cells correlates with a proclivity toward ITP and autoimmune ..
  33. Measuring the impact of prenatal alcohol exposure on the fetal epigenome
    Michael C Golding; Fiscal Year: 2011
    ..is the development of a Green Fluorescent Protein (GFP) containing retro-element reporter based on the agouti-IAP element...
  34. Is Aberrant MO Stimulation Pivotal in Post-Trauma MODS?
    Carol L Miller-Graziano; Fiscal Year: 2012
    ..bacteremia with 1) MO that express a unique cohorts of interactive, inhibitory mediators/receptors including TSP-1, CD47, SIRP1, 2) inhibitory DC with low costimulatory receptors increased coinhibitory receptors &altered mediators (..
  35. A Novel Role of Macrophage TSP1-CD47 Signaling in Atherosclerosis
    Gabor Csanyi; Fiscal Year: 2013
    ..in the field of cardiovascular science with specific focus on the role of thrombospondin-1 (TSP1)-mediated CD47 signaling in atherosclerosis and vascular free radical biology...
  36. Urokinase, Neutrophil Activation and Acute Lung Injury.
    Gang Liu; Fiscal Year: 2013
    ..the expression of receptors and ligands involved in phagocytosis of neutrophils, including calreticulin (CRT), CD47, CD31, integrins, mer, axl, and LRP, as well as in affecting the binding of opsonins to PtdSer and of collectins to ..
  37. Development of a forced air add-on attachment for rocket stoves in Kenya capable
    NATHAN LORENZ; Fiscal Year: 2013
    ..This indoor air pollution (IAP) has been linked to nearly 3% of the global burden of disease and is a major contributor to as many as 2 million ..
  38. A POLYMERIC DRUG DELIVERY SYSTEM FOR CANCER THERAPY
    JINDRICH H KOPECEK; Fiscal Year: 2010
    ..Combinatorial chemistry approaches will be used to identify human ovarian carcinoma CD47 binding peptides. A secondary library will be constructed based on results of alanine scanning...
  39. The Environment and Epigenome: Interplay of Toxicants and Transposons in Mammals
    CHRISTOPHER DON FAULK; Fiscal Year: 2013
    ..Intriguingly, the candidate's preliminary evidence shows that two intracisternal A particle (IAP) transposons associated with metastable epialleles in mice have a higher sequence similarity to each other than to ..
  40. Targeting eIF2alpha siRNA to alpha(v)beta(3) Integrin-bearing Tumor Cells
    Ching An Peng; Fiscal Year: 2010
    ..phagocytosis of eIF2? siRNA carriers, we propose to conjugate the "marker of self" integrin-associated protein (CD47) to chitosan-based siRNA carriers...
  41. THYROID HORMONE AND THE GUT
    Richard A Hodin; Fiscal Year: 2010
    ..This proposal is based upon a novel hypothesis that the loss of intestinal alkaline phosphatase (IAP) expression underlies the impairment in gut mucosal defense that occurs in critically ill patients...
  42. Targeting thrombospondin 1 in bone resorption
    KARL LEONARD INSOGNA; Fiscal Year: 2013
    ..CD47, also known as Integrin Associated Protein, is a binding partner for two ligands, TSP1 and SIRP11...
  43. Impaired intestinal barrier function and airway inflammation in cystic fibrosis
    Robert C De Lisle; Fiscal Year: 2010
    ..of this project is that impaired intestinal innate defenses in CF, including decreased alkaline phosphatase (IAP) activity, compromised gut barrier function, and small intestinal bacterial overgrowth, contribute to the excessive ..
  44. Targeted Inhibition of Innate Immunosurveillance to Promote the Engraftment of He
    NATHANIEL FERNHOFF; Fiscal Year: 2013
    ..b>CD47 is a ubiquitously expressed "don't eat me signal" that negative regulates macrophage activation and ..
  45. MOLECULAR CHARACTERIZATION OF ACUTE MYELOID LEUKEMIA
    Irving L Weissman; Fiscal Year: 2013
    ..Finally, we will examine whether CD47 expression (a 'don't eat me'signal) on leukemic cells renders them invisible to the innate (..
  46. Particulate matter and black carbon:Respiratory Health in Sri Lankan Children
    Sumal Nandasena; Fiscal Year: 2013
    ..Incomplete combustion of solid fuel is the major contributor to indoor air pollution (IAP) in developing countries...
  47. Optical Imaging of Bladder Cancer with Molecular Contrast Agents
    Joseph C Liao; Fiscal Year: 2013
    ..phage display technology and whole organ biopanning to identify bladder cancer-binding peptides;and 3) identified CD47 as a promising therapeutic and imaging target for bladder cancer...
  48. TSP1-CD47 in Promotion of PAH-Associated Vasoconstriction and Vascular Overgrowth
    Jeffrey S Isenberg; Fiscal Year: 2013
    ..Preliminary data suggests that TSP1, in binding to its necessary receptor CD47, inhibits activation of endothelial nitric oxide synthase (eNOS) and thus endothelial NO production, and that TSP1 ..
  49. Tumor-toxic CD47 mAb therapy for leukemia: a proof of concept study
    William A Frazier; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): CD47 has emerged as a novel therapeutic target in hematologic cancers. Leukemias expressing the highest levels of CD47 have the worst prognosis...
  50. Microglial Signaling Mechanisms in Alzheimer's Disease
    Gary E Landreth; Fiscal Year: 2010
    ..The principal elements of this complex are the alpha6beta1 integrin, the integrin associated protein CD47, the B-class scavenger receptor CD36, and scavenger receptor A...
  51. Neurofibrillary Tangle-Induced Dementia in AD
    Travis L Dunckley; Fiscal Year: 2010
    ..In the proposed study it is hypothesized that the CD47 signaling pathway contributes to abnormalities in tau metabolism, NFT formation, and neuronal cell death and ..
  52. Role of CD47 in xenograft rejection by macrophages
    Yong Guang Yang; Fiscal Year: 2013
    ..b>CD47 is ubiquitously expressed and serves as a ligand of SIRP?, an inhibitory receptor on macrophages and DCs...
  53. Training in Immunology and Aging
    Pamela L Witte; Fiscal Year: 2010
    ..An interdepartmental Immunology and Aging Program (IAP) was established for encouraging aging research on the LUMC campus...
  54. GalT-KO Pigs Expressing Primate CD47 to Facilitate Organ Xenografts
    David H Sachs; Fiscal Year: 2013
    ..We will achieve this goal by overcoming the species incompatibility of the CD47 (IAP, integrin associated protein) cell surface molecule, which appears to be the key barrier to the establishment of chimerism following ..
  55. Increasing biocompatibility of stents through CD47 functionalization
    STANLEY JOSEPH STACHELEK; Fiscal Year: 2013
    ..b>CD47 has been identified as a ligand for the immune inhibitory receptor SIRP[unreadable] and has been shown to confer "..
  56. CD47 and hematoma clearance in intracerebral hemorrhage
    Ya Hua; Fiscal Year: 2013
    ..found that enhancing microglia/macrophage-mediated hematoma clearance improves functional outcome after ICH, and CD47 has an important role in erythrophagocytosis...
  57. Identification of cancer stem cell therapeutic targets
    Michael Clarke; Fiscal Year: 2013
    ..PI Mike Clarke, Stanford University. Project 2: Therapeutic targeting of CD47 on human leukemia and other cancer stem cells PI, Irv Weissman, Stanford University...
  58. Structural and functional elucidation of the necrosome in innate immune signaling
    Hao Wu; Fiscal Year: 2013
    ..is blocked by removal of the E3 ligases cIAP1 and cIAP2 through genetic ablation, RNAi knock down, or IAP antagonists, RIP1 forms a secondary complex with FADD and caspase-8 to initiate apoptotic cell death...
  59. Treatment of Transplant Reperfusion with an Anti-CD47 Antibody
    PAMELA TOY MANNING; Fiscal Year: 2009
    ..The founders of Vasculox, Inc have discovered a receptor, CD47, that continually opposes the action of beneficial NO in all vascular cells...
  60. Mechanisms of Microglial Activation and Phagocytosis in*
    Gary Landreth; Fiscal Year: 2005
    ..We will cross mice overexpressing the human APP gene with animals in which the integrin-associated protein (IAP)/CD47, the B-class scavenger receptor CD36, or complement receptor CD18 genes have been knocked out, and seek to ..
  61. INTESTINAL PROTEIN METABOLISM AND FUNCTION
    David Alpers; Fiscal Year: 2000
    Intestinal alkaline phosphatase (IAP) in the rat provides a model for studying a unique mechanism of protein secretion from the enterocyte, in that IAP isomers I and II are secreted from the cell bound to a phospholipid-rich surfactant-..
  62. ROLE OF G PROTEINS IN PROLACTIN SIGNAL TRANSDUCTION
    Jennifer Larsen; Fiscal Year: 1993
    ..Previously, it has been shown that bacterial toxins, pertussis toxin, (islet activating protein: IAP) and cholera toxin (CT), can modify PRL-stimulated mitogenesis in the Nb2 cell...
  63. CD47 as a neurovascular target for stroke therapy
    Eng H Lo; Fiscal Year: 2010
    ..Here, we propose that the transmembrane receptor CD47 (also known as integrin associated protein) may be an ideal neurovascular target for stroke therapy...
  64. Development of a humanized anti-CD47 antibody for treatment of tissue ischemia.
    William Frazier; Fiscal Year: 2009
    ..Thrombospondin-1 (TSP1) and its receptor, CD47, are present in all vascular tissues and limit NO signaling, thus worsening tissue ischemia, promoting thrombosis ..
  65. INTEGRIN ASSOCIATED PROTEIN IS A THROMBOSPONDIN RECEPTOR
    William Frazier; Fiscal Year: 2000
    ..We have found that integrin associated protein or IAP (CD47) is a receptor for the C-terminal cell binding domain (CBD) of TS1...