CD47

Summary

Gene Symbol: CD47
Description: CD47 molecule
Alias: IAP, MER6, OA3, leukocyte surface antigen CD47, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 glycoprotein, Rh-related antigen, antigen identified by monoclonal antibody 1D8, antigenic surface determinant protein OA3, integrin associated protein, integrin-associated signal transducer
Species: human
Products:     CD47

Top Publications

  1. Mateo V, Lagneaux L, Bron D, Biron G, Armant M, Delespesse G, et al. CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia. Nat Med. 1999;5:1277-84 pubmed
    ..We report here that engagement of CD47, a newly described thrombospondin receptor, by immobilized monoclonal antibody against CD47 or by thrombospondin ..
  2. Piccio L, Vermi W, Boles K, Fuchs A, Strader C, Facchetti F, et al. Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. Blood. 2005;105:2421-7 pubmed
    ..SIRPalpha binds CD47 and inhibits the function of macrophages, dendritic cells, and granulocytes, whereas SIRPbeta1 is an orphan ..
  3. Lagadec P, Dejoux O, Ticchioni M, Cottrez F, Johansen M, Brown E, et al. Involvement of a CD47-dependent pathway in platelet adhesion on inflamed vascular endothelium under flow. Blood. 2003;101:4836-43 pubmed
    ..Using human platelets or platelets from wild-type and CD47-/- mice in whole blood, we demonstrated that at low shear rate, CD47 expressed on human and mouse platelets ..
  4. Sarfati M, Fortin G, Raymond M, Susin S. CD47 in the immune response: role of thrombospondin and SIRP-alpha reverse signaling. Curr Drug Targets. 2008;9:842-50 pubmed
    ..b>CD47 and its two ligands, i.e...
  5. Subramanian S, Boder E, Discher D. Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site. J Biol Chem. 2007;282:1805-18 pubmed
    Cell-cell interactions between ubiquitously expressed integrin-associated protein (CD47) and its counterreceptor signal regulatory protein (SIRPalpha) on phagocytes regulate a wide range of adhesive signaling processes, including the ..
  6. Raymond M, Rubio M, Fortin G, Shalaby K, Hammad H, Lambrecht B, et al. Selective control of SIRP-alpha-positive airway dendritic cell trafficking through CD47 is critical for the development of T(H)2-mediated allergic inflammation. J Allergy Clin Immunol. 2009;124:1333-42.e1 pubmed publisher
    ..b>CD47, a signal regulatory protein (SIRP)-alpha partner, reportedly governed skin DC migration...
  7. Jaiswal S, Jamieson C, Pang W, Park C, Chao M, Majeti R, et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009;138:271-85 pubmed publisher
    Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPalpha, to inhibit phagocytosis of normal, healthy cells...
  8. Mateo V, Brown E, Biron G, Rubio M, Fischer A, Deist F, et al. Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization. Blood. 2002;100:2882-90 pubmed
    Dying cells, apoptotic or necrotic, are swiftly eliminated by professional phagocytes. We previously reported that CD47 engagement by CD47 mAb or thrombospondin induced caspase-independent cell death of chronic lymphocytic leukemic B ..
  9. Lindberg F, Gresham H, Schwarz E, Brown E. Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding. J Cell Biol. 1993;123:485-96 pubmed
    b>Integrin Associated Protein (IAP) is a 50-kD membrane protein which copurifies with the integrin alpha v beta 3 from placenta and coimmunoprecipitates with beta 3 from platelets...

More Information

Publications81

  1. Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, CROCE K, Fukuda D, et al. Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo. J Immunol. 2012;189:2553-62 pubmed publisher
    ..We previously reported that adhesive interactions between endothelial cell CD47 and leukocyte signal regulatory protein ? (SIRP?) regulate human T cell TEM...
  2. Brown E, Hooper L, Ho T, Gresham H. Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins. J Cell Biol. 1990;111:2785-94 pubmed
    ..For this reason, we call it Integrin-associated Protein (IAP). We hypothesize that IAP may play a role in signal transduction for enhanced phagocytosis by Arg-Gly-Asp ligands.
  3. Tian L, Rauvala H, Gahmberg C. Neuronal regulation of immune responses in the central nervous system. Trends Immunol. 2009;30:91-9 pubmed publisher
    ..In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity. ..
  4. Kim M, Lee J, Lee J, Kim S, Lee S, Park S, et al. Association of CD47 with natural killer cell-mediated cytotoxicity of head-and-neck squamous cell carcinoma lines. Tumour Biol. 2008;29:28-34 pubmed publisher
    Integrin-associated protein (CD47) binds specifically to the inhibitory receptor signal-regulatory protein. This study was designed to evaluate the role of CD47 in natural killer (NK) cell-mediated cytotoxicity against cancer cells...
  5. Tsai R, Discher D. Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. J Cell Biol. 2008;180:989-1003 pubmed publisher
    ..particles by macrophages is a rapid process that is inefficient when faced with "self" cells that display CD47-although signaling mechanisms in self-recognition have remained largely unknown...
  6. Barclay A, Brown M. The SIRP family of receptors and immune regulation. Nat Rev Immunol. 2006;6:457-64 pubmed
    ..In this Review, we describe recent studies defining the ligands of the SIRP-family members, with particular emphasis on relating the molecular interactions of these proteins to their role in immune-cell regulation. ..
  7. Manna P, Dimitry J, Oldenborg P, Frazier W. CD47 augments Fas/CD95-mediated apoptosis. J Biol Chem. 2005;280:29637-44 pubmed
    ..Jurkat T cells lacking CD47 (integrin-associated protein) are relatively resistant to Fas-mediated death but are efficiently killed by Fas ..
  8. Brittain J, Han J, Ataga K, Orringer E, Parise L. Mechanism of CD47-induced alpha4beta1 integrin activation and adhesion in sickle reticulocytes. J Biol Chem. 2004;279:42393-402 pubmed
    We recently reported that CD47 (integrin-associated protein) on sickle red blood cells (SS RBCs) activates G-protein-dependent signaling, which promotes cell adhesion to immobilized thrombospondin (TSP) under relevant shear stress...
  9. Dahl K, Parthasarathy R, Westhoff C, Layton D, Discher D. Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells. Blood. 2004;103:1131-6 pubmed
    The reduction in expression of the integral membrane protein CD47 in human red blood cells (RBCs) deficient in protein 4.2 suggests that protein 4.2 may mediate a linkage of CD47 to the membrane skeleton...
  10. Lamy L, Ticchioni M, Rouquette Jazdanian A, Samson M, Deckert M, Greenberg A, et al. CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis. J Biol Chem. 2003;278:23915-21 pubmed
    b>CD47 is a surface receptor that induces either coactivation or apoptosis in lymphocytes, depending on the ligand(s) bound...
  11. Mouro Chanteloup I, Delaunay J, Gane P, Nicolas V, Johansen M, Brown E, et al. Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47. Blood. 2003;101:338-44 pubmed
    ..the linking protein(s) between the red cell skeleton and the Rh complex, we analyzed the expression of Rh, RhAG, CD47, LW, and glycophorin B proteins in red cells from patients with hereditary spherocytosis associated with complete ..
  12. Rebres R, Vaz L, Green J, Brown E. Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. J Biol Chem. 2001;276:34607-16 pubmed
    b>CD47 is a unique member of the Ig superfamily with a single extracellular Ig domain followed by a multiply membrane-spanning (MMS) domain with five transmembrane segments, implicated in both integrin-dependent and -independent signaling ..
  13. Fujimoto T, Katsutani S, Shimomura T, Fujimura K. Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphaIIbbeta3 by its extracellular domain. J Biol Chem. 2003;278:26655-65 pubmed
    Integrin-associated protein (IAP/CD47) is a receptor for the C-terminal cell binding domain of thrombospondin (TS)...
  14. Lascorz J, Bevier M, V Schönfels W, Kalthoff H, Aselmann H, Beckmann J, et al. Association study identifying polymorphisms in CD47 and other extracellular matrix pathway genes as putative prognostic markers for colorectal cancer. Int J Colorectal Dis. 2013;28:173-81 pubmed publisher
    ..The eSNP (SNP associated with expression) rs12695175 in CD47 associated with CRC specific survival (HR?=?2.18, 95 % CI 1.10-4...
  15. Han M, Lundgren D, Jaiswal S, Chao M, Graham K, Garris C, et al. Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med. 2012;209:1325-34 pubmed publisher
    ..and proteomic data from pathologically similar multiple sclerosis (MS) lesions reveals down-regulation of CD47 at the messenger RNA level and low abundance at the protein level...
  16. Rock M, Holden P, Horton W, Cohn D. Cartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and alphaVbeta3 integrin. Mol Cell Biochem. 2010;338:215-24 pubmed publisher
    ..Function-blocking antibodies to CD47 and alphaVbeta3 integrin reduced cell attachment to COMP, implicating the participation of these cell surface ..
  17. Junker A, Krumbholz M, Eisele S, Mohan H, Augstein F, Bittner R, et al. MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain. 2009;132:3342-52 pubmed publisher
    ..This converged on CD47, which functions as a 'don't eat me' signal inhibiting macrophage activity...
  18. Hatherley D, Graham S, Harlos K, Stuart D, Barclay A. Structure of signal-regulatory protein alpha: a link to antigen receptor evolution. J Biol Chem. 2009;284:26613-9 pubmed publisher
    Signal-regulatory protein alpha (SIRPalpha) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self...
  19. Hatherley D, Graham S, Turner J, Harlos K, Stuart D, Barclay A. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Mol Cell. 2008;31:266-77 pubmed publisher
    b>CD47 is a widely distributed cell-surface protein that acts a marker of self through interactions of myeloid and neural cells...
  20. McDonald J, Zheleznyak A, Frazier W. Cholesterol-independent interactions with CD47 enhance alphavbeta3 avidity. J Biol Chem. 2004;279:17301-11 pubmed
    Expression in OV10 cells of either wild-type CD47 or its extracellular IgV domain linked to a glycosylphosphatidylinositol anchor-(IgV-GPI) enhanced ligand-induced alpha(v)beta(3) activation as detected by the binding of LIBS1 and LIBS6 ..
  21. Barazi H, Li Z, Cashel J, Krutzsch H, Annis D, Mosher D, et al. Regulation of integrin function by CD47 ligands. Differential effects on alpha vbeta 3 and alpha 4beta1 integrin-mediated adhesion. J Biol Chem. 2002;277:42859-66 pubmed
    We examined the regulation of alpha4beta1 integrin function in melanoma cells and T cells by ligands of CD47. A CD47 antibody (B6H12) that inhibited alphavbeta3-mediated adhesion of melanoma cells induced by CD47-binding peptides from ..
  22. Ide K, Wang H, Tahara H, Liu J, Wang X, Asahara T, et al. Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci U S A. 2007;104:5062-6 pubmed
    ..regulatory protein (SIRP)alpha is a critical immune inhibitory receptor on macrophages, and its interaction with CD47, a ligand for SIRPalpha, prevents autologous phagocytosis...
  23. Erb L, Liu J, Ockerhausen J, Kong Q, Garrad R, Griffin K, et al. An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction. J Cell Biol. 2001;153:491-501 pubmed
    ..by antibodies against alpha(V)beta(3)/beta(5) integrins and the integrin-associated thrombospondin receptor, CD47. Immunofluorescence of cells transfected with epitope-tagged P2Y(2)Rs indicated that alpha(V) integrins colocalized ..
  24. Subramanian S, Tsai R, Sen S, Dahl K, Discher D. Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling. Blood Cells Mol Dis. 2006;36:364-72 pubmed
    b>Integrin Associated Protein (IAP, CD47) is a ubiquitous integral membrane protein implicated in processes (in mice) that range from inhibiting clearance by phagocytes [Oldenborg et al., Science 2000; Gardai et al...
  25. Latour S, Tanaka H, Demeure C, Mateo V, Rubio M, Brown E, et al. Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation. J Immunol. 2001;167:2547-54 pubmed
    ..In this study, we first show that CD47/integrin-associated protein, a ubiquitous multispan transmembrane protein highly expressed on T cells, interacts ..
  26. Bouguermouh S, Van V, Martel J, Gautier P, Rubio M, Sarfati M. CD47 expression on T cell is a self-control negative regulator of type 1 immune response. J Immunol. 2008;180:8073-82 pubmed
    ..Yet, the control of Th1 polarization by T cell surface molecules remains ill-defined. We here report that CD47 expression on T cells serves as a self-control mechanism to negatively regulate type 1 cellular and humoral immune ..
  27. Willingham S, Volkmer J, Gentles A, Sahoo D, Dalerba P, Mitra S, et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A. 2012;109:6662-7 pubmed publisher
    b>CD47, a "don't eat me" signal for phagocytic cells, is expressed on the surface of all human solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue revealed that CD47 is overexpressed on cancer cells...
  28. Gao A, Lindberg F, Finn M, Blystone S, Brown E, Frazier W. Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. J Biol Chem. 1996;271:21-4 pubmed
    ..CBD of TS1 affinity label a 52-kDa cell surface glycoprotein, which we show is integrin-associated protein (IAP or CD47). IAP associates with alpha v beta 3 and thereby modulates the activity of several integrins...
  29. Chung J, Gao A, Frazier W. Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3. J Biol Chem. 1997;272:14740-6 pubmed
    Integrin-associated protein (IAP or CD47) is a receptor for the cell/platelet-binding domain (CBD) of thrombospondin-1 (TS1), the most abundant protein of platelet alpha granules...
  30. Jiang P, Lagenaur C, Narayanan V. Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem. 1999;274:559-62 pubmed
    ..Here we report that integrin-associated protein (IAP/CD47) is a predominant binding partner of P84...
  31. Floquet N, Dedieu S, Martiny L, Dauchez M, Perahia D. Human thrombospondin's (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: a molecular modeling study. Arch Biochem Biophys. 2008;478:103-9 pubmed publisher
    ..We also suggest a common opening mechanism for proteins sharing the same fold as TSP-1. This work also suggests the usefulness of our approach in other topics in which predictions of protein-protein interactions are of importance. ..
  32. Brown E, Frazier W. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 2001;11:130-5 pubmed
    Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, ..
  33. Stefanidakis M, Newton G, Lee W, Parkos C, Luscinskas F. Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. Blood. 2008;112:1280-9 pubmed publisher
    Leukocyte transendothelial migration (TEM) is a critical event during inflammation. CD47 has been implicated in myeloid cell migration across endothelium and epithelium...
  34. Wu A, Wang J, Zheleznyak A, Brown E. Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Mol Cell. 1999;4:619-25 pubmed
    Integrin-associated protein (IAP, CD47) is a plasma membrane receptor for thrombospondins and signal regulatory proteins (SIRPs) that has an essential role in host defense through its association with integrins...
  35. Tomoshige S, Nomura S, Ohgane K, Hashimoto Y, Ishikawa M. Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative. Bioorg Med Chem Lett. 2018;28:707-710 pubmed publisher
    ..ligand, we synthesized a similar Htt degrader utilizing MV1, an antagonist of the inhibitor of apoptosis protein (IAP) family (a subgroup of ubiquitin E3 ligases), which is expected to have a higher affinity and specificity for IAP, ..
  36. Li Y, Ren J, Wu X, Li J. Intra-abdominal infection combined with intra-abdominal hypertension aggravates the intestinal mucosal barrier dysfunction. Biosci Rep. 2018;38: pubmed publisher
    ..IAI model: cecal ligation and puncture for 48 h; IAH model: raised intra-abdominal pressure (IAP) of 20 mmHg for 4 h...
  37. Xiao H, Sun Z, Wan J, Hou S, Xiong Y. Overexpression of protocadherin 7 inhibits neuronal survival by downregulating BIRC5 in vitro. Exp Cell Res. 2018;366:71-80 pubmed publisher
    ..revealed that 12 genes were involved in the apoptotic pathway including baculoviral inhibitor of apoptosis (IAP) repeat containing 5 (BIRC5)...
  38. Kim J, Sinha S, Solomon M, Perez Herrero E, Hsu J, Tsinas Z, et al. Co-coating of receptor-targeted drug nanocarriers with anti-phagocytic moieties enhances specific tissue uptake versus non-specific phagocytic clearance. Biomaterials. 2017;147:14-25 pubmed publisher
    ..Coating NCs with CD47, a protein expressed by body cells to avoid phagocytic removal, offers an alternative...
  39. Zhang J, Yan X, Lan B, Lei Y, Li X, Gao S, et al. Molecular mechanisms of synergistic induction of apoptosis by the combination therapy with hyperthermia and cisplatin in prostate cancer cells. Biochem Biophys Res Commun. 2016;479:159-165 pubmed publisher
    ..We also found that the combination therapy could down-regulate the anti-apoptotic Bcl-2 and IAP family proteins...
  40. Angelici A, Perotti B, Dezzi C, Amatucci C, Mancuso G, Caronna R, et al. Measurement of intra-abdominal pressure in large incisional hernia repair to prevent abdominal compartmental syndrome. G Chir. 2016;37:31-6 pubmed
    The repair of large incisional hernias may occasionally lead to a substantial increase in intra-abdominal pressure (IAP), and rarely to abdominal compartmental syndrome (ACS) with subsequent respiratory, vascular, and visceral ..
  41. Ingram J, Blomberg O, Sockolosky J, Ali L, Schmidt F, Pishesha N, et al. Localized CD47 blockade enhances immunotherapy for murine melanoma. Proc Natl Acad Sci U S A. 2017;114:10184-10189 pubmed publisher
    b>CD47 is an antiphagocytic ligand broadly expressed on normal and malignant tissues that delivers an inhibitory signal through the receptor signal regulatory protein alpha (SIRP?)...
  42. Guo Y, Jiang W, Wu P, Liu Y, Zhou X, Kuang S, et al. The decreased growth performance and impaired immune function and structural integrity by dietary iron deficiency or excess are associated with TOR, NF-?B, p38MAPK, Nrf2 and MLCK signaling in head kidney, spleen and skin of grass carp (Ctenopharyngod. Fish Shellfish Immunol. 2017;65:145-168 pubmed publisher
    ..the mRNA levels of B-cell lymphoma-2 (Bcl-2), myeloid cell leukemia 1 (Mcl-1), and inhibitor of apoptosis protein (IAP), and decreased activities and mRNA levels of antioxidant enzymes, down-regulated the mRNA levels of NF-E2-related ..
  43. Fulda S. Smac Mimetics to Therapeutically Target IAP Proteins in Cancer. Int Rev Cell Mol Biol. 2017;330:157-169 pubmed publisher
    Inhibitor of Apoptosis (IAP) proteins are overexpressed in a variety of human cancers. Therefore, they are considered as promising targets for the design of therapeutic strategies...
  44. Vasudevan D, Ryoo H. Regulation of Cell Death by IAPs and Their Antagonists. Curr Top Dev Biol. 2015;114:185-208 pubmed publisher
    Inhibitors of apoptosis (IAPs) family of genes encode baculovirus IAP-repeat domain-containing proteins with antiapoptotic function...
  45. Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, et al. Development of a peptide-based inducer of nuclear receptors degradation. Bioorg Med Chem Lett. 2016;26:2655-8 pubmed publisher
    ..the estrogen receptor ? (ER?) surface and an MV1 molecule that binds to cellular inhibitors of apoptosis proteins (IAP: cIAP1/cIAP2/XIAP) to induce ubiquitylation of the ER?...
  46. Chesi M, Mirza N, Garbitt V, Sharik M, Dueck A, Asmann Y, et al. IAP antagonists induce anti-tumor immunity in multiple myeloma. Nat Med. 2016;22:1411-1420 pubmed publisher
    ..Consequently, small-molecule IAP antagonists, such as LCL161, have entered clinical trials for their ability to induce tumor necrosis factor (TNF)-..
  47. Kochmanski J, Marchlewicz E, Savidge M, Montrose L, Faulk C, Dolinoy D. Longitudinal effects of developmental bisphenol A and variable diet exposures on epigenetic drift in mice. Reprod Toxicol. 2017;68:154-163 pubmed publisher
    ..Methylation was quantified at two repetitive elements (LINE-1, IAP), two imprinted genes (Igf2, H19), and one non-imprinted gene (Esr1) in isogenic mice developmentally exposed to ..
  48. Naing S, Vukoti K, Drury J, Johnson J, Kalyoncu S, Hill S, et al. Catalytic Properties of Intramembrane Aspartyl Protease Substrate Hydrolysis Evaluated Using a FRET Peptide Cleavage Assay. ACS Chem Biol. 2015;10:2166-74 pubmed publisher
    ..We developed a FRET peptide assay for the intramembrane aspartyl protease (IAP) from Methanoculleus marisnigri JR1 in combination with quantitative mass spectrometry cleavage site analysis...
  49. Trujillo G, Zhang J, Habiel D, Ge L, Ramadass M, Ghebrehiwet B, et al. Cofactor regulation of C5a chemotactic activity in physiological fluids. Requirement for the vitamin D binding protein, thrombospondin-1 and its receptors. Mol Immunol. 2011;49:495-503 pubmed publisher
    ..better characterize these chemotactic cofactors and investigate the role that cell surface TSP-1 receptors CD36 and CD47 may play in this process...
  50. Gao Q, Chen K, Gao L, Zheng Y, Yang Y. Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells. Cell Death Dis. 2016;7:e2368 pubmed publisher
    b>CD47 signaling in endothelial cells has been shown to suppress angiogenesis, but little is known about the link between CD47 and endothelial senescence...
  51. Ardisson Araujo D, da Silva A, Melo F, Dos Santos E, Sosa Gómez D, Ribeiro B. A Novel Betabaculovirus Isolated from the Monocot Pest Mocis latipes (Lepidoptera: Noctuidae) and the Evolution of Multiple-Copy Genes. Viruses. 2018;10: pubmed publisher
    ..open reading frames (ORFs) were found to be unique to MolaGV and several auxiliary genes were found including iap-3, iap-5, bro-a, bro-b, and three enhancins...
  52. Silke J, Vince J. IAPs and Cell Death. Curr Top Microbiol Immunol. 2017;403:95-117 pubmed publisher
    ..To come full circle, the IAP antagonist drugs that were developed to sensitise cancer cells to apoptosis have led to some of these insights.
  53. Vanker A, Barnett W, Workman L, Nduru P, Sly P, Gie R, et al. Early-life exposure to indoor air pollution or tobacco smoke and lower respiratory tract illness and wheezing in African infants: a longitudinal birth cohort study. Lancet Planet Health. 2017;1:e328-e336 pubmed publisher
    Indoor air pollution (IAP) and environmental tobacco smoke (ETS) are associated with lower respiratory tract illness (LRTI) or wheezing in children...
  54. Sharma S, Kaufmann T, Biswas S. Impact of inhibitor of apoptosis proteins on immune modulation and inflammation. Immunol Cell Biol. 2017;95:236-243 pubmed publisher
    ..focus on modulation of the innate and adaptive immune systems, macrophage plasticity and inflammatory responses by IAP family members...
  55. Nagahara M, Mimori K, Kataoka A, Ishii H, Tanaka F, Nakagawa T, et al. Correlated expression of CD47 and SIRPA in bone marrow and in peripheral blood predicts recurrence in breast cancer patients. Clin Cancer Res. 2010;16:4625-35 pubmed publisher
    b>CD47 plays a variety of roles in intercellular signaling. Herein, we focused on the clinicopathologic significance of CD47 expression in human breast cancer...
  56. Chao M, Jaiswal S, Weissman Tsukamoto R, Alizadeh A, Gentles A, Volkmer J, et al. Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med. 2010;2:63ra94 pubmed publisher
    ..b>CD47, which prevents cancer cell phagocytosis by the innate immune system, is highly expressed on several human cancers ..
  57. Taniguchi F, Uegaki T, Nakamura K, Mon K, Harada T, Ohbayashi T, et al. Inhibition of IAP (inhibitor of apoptosis) proteins represses inflammatory status via nuclear factor-kappa B pathway in murine endometriosis lesions. Am J Reprod Immunol. 2017;: pubmed publisher
    ..How is the role of inhibitor of apoptosis proteins (IAPs) in the development of murine endometriosis lesions?..
  58. Ha B, Lv Z, Bian Z, Zhang X, Mishra A, Liu Y. 'Clustering' SIRPα into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47. PLoS ONE. 2013;8:e77615 pubmed publisher
    ..signaling receptor, negatively regulates leukocyte responses through extracellular interactions with CD47. However, the dynamics of SIRPα-CD47 interactions on the cell surface and the governing mechanisms remain ..
  59. Sun F, Zhang C, Chen X, Wei Y, Li S, Liu S, et al. Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex. J Neuroinflammation. 2016;13:85 pubmed publisher
    ..The membrane glycoproteins CD47 and CD200, which are highly expressed in neurons and other cells, mediate inhibitory signals through their ..
  60. Zolotarenko A, Chekalin E, Mehta R, Baranova A, Tatarinova T, Bruskin S. Identification of Transcriptional Regulators of Psoriasis from RNA-Seq Experiments. Methods Mol Biol. 2017;1613:355-370 pubmed publisher
    ..factor is an important player in psoriasis, as it inhibits maturation of naive T cells into this Treg subpopulation (CD4+FOXA1+CD47+CD69+PD-L1(hi)FOXP3-), therefore contributing to the development of psoriatic skin lesions.
  61. Yu G, Bu L, Huang C, Zhang W, Chen W, Gutkind J, et al. PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma. Oncotarget. 2015;6:42067-80 pubmed publisher
    ..Molecular analysis suggests a reduction in the CD47/SIRPα pathway by PD-1 blockade, which regulates MDSCs, TAMs, dendritic cell as well as effector T cells...
  62. Cooney T, Wei M, Rangaswami A, Xu L, Sage J, Hazard F. CD47 is not Over-Expressed in Fibrolamellar Hepatocellular Carcinoma. Ann Clin Lab Sci. 2017;47:395-402 pubmed
    b>CD47 is a transmembrane receptor that inhibits phagocytosis. Over-expression of CD47 is associated with an increased risk of tumor growth and metastasis...
  63. Zaghloul H, Hice R, Arensburger P, Federici B. Transcriptome Analysis of the Spodoptera frugiperda Ascovirus In Vivo Provides Insights into How Its Apoptosis Inhibitors and Caspase Promote Increased Synthesis of Viral Vesicles and Virion Progeny. J Virol. 2017;91: pubmed publisher
    ..Inhibitors of apoptosis (IAP-like proteins; ORF016, ORF025, and ORF074) were expressed early, whereas its caspase (ORF073) was expressed very ..
  64. Gilani S, Howarth G, Nattrass G, Kitessa S, Barekatain R, Forder R, et al. Gene expression and morphological changes in the intestinal mucosa associated with increased permeability induced by short-term fasting in chickens. J Anim Physiol Anim Nutr (Berl). 2017;: pubmed publisher
    ..protection including glucagon-like peptide (GLP-2), heat-shock protein (HSP-70), intestinal alkaline phosphatase (IAP), mammalian target of rapamycin (mTOR), toll-like receptors (TLR-4), mucin (MUC-2), cluster differentiation (CD-36) ..
  65. Yang M, Liu B, Jin L, Tao H, Yang Z. Estrogen receptor ? exhibited anti-tumor effects on osteosarcoma cells by regulating integrin, IAP, NF-kB/BCL-2 and PI3K/Akt signal pathway. J Bone Oncol. 2017;9:15-20 pubmed publisher
    ..The expression of Inhibitor of apoptosis protein (IAP) and integrin ?5 in U2-OS cells of each group was detected by quantitative RT-PCR, and the expression of ..
  66. Le Doaré K, O Driscoll M, Turner K, Seedat F, Russell N, Seale A, et al. Intrapartum Antibiotic Chemoprophylaxis Policies for the Prevention of Group B Streptococcal Disease Worldwide: Systematic Review. Clin Infect Dis. 2017;65:S143-S151 pubmed publisher
    Intrapartum antibiotic chemoprophylaxis (IAP) prevents most early-onset group B streptococcal (GBS) disease. However, there is no description of how IAP is used around the world...
  67. Ring N, Herndler Brandstetter D, Weiskopf K, Shan L, Volkmer J, George B, et al. Anti-SIRP? antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proc Natl Acad Sci U S A. 2017;114:E10578-E10585 pubmed publisher
    ..signal regulatory protein-? (SIRP?) is a myeloid-specific immune checkpoint that engages the "don't eat me" signal CD47 expressed on tumors and normal tissues...
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    ..SSL6 is the first bacterial protein identified that binds CD47, a widely expressed cell surface protein recently described as an interesting target in anti-cancer therapy...
  69. Ho C, Guo N, Sockolosky J, Ring A, Weiskopf K, Özkan E, et al. "Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein α (SIRPα) antagonists that enhance antibody-dependent cellular phagocytosis. J Biol Chem. 2015;290:12650-63 pubmed publisher
    b>CD47 is a cell surface protein that transmits an anti-phagocytic signal, known as the "don't-eat-me" signal, to macrophages upon engaging its receptor signal regulatory protein α (SIRPα)...
  70. Azcutia V, Bassil R, Herter J, Engelbertsen D, Newton G, Autio A, et al. Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE. J Leukoc Biol. 2017;101:493-505 pubmed publisher
    b>CD47 is known to play an important role in CD4+ T cell homeostasis...
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    ..synthesis and biological evaluation of novel hybrid compounds 4a and 4b consisting of alkyl chloride linked to IAP antagonist MV1 (5)...
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    ..In chemoresistant hepatospheres, CD47 was found to be up-regulated, when compared with differentiated progenies...