CD47

Summary

Gene Symbol: CD47
Description: CD47 molecule
Alias: IAP, MER6, OA3, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 glycoprotein, Rh-related antigen, antigen identified by monoclonal antibody 1D8, antigenic surface determinant protein OA3, integrin associated protein, integrin-associated protein, integrin-associated signal transducer, leukocyte surface antigen CD47
Species: human

Top Publications

  1. ncbi CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia
    V Mateo
    Laboratoire d allergie, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, 1560 rue Sherbrooke Est, Université de Montréal H2L 4M1, Quebec, Canada
    Nat Med 5:1277-84. 1999
  2. ncbi C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma-chain-associated signaling pathway and by agglutination
    D Tulasne
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 98:3346-52. 2001
  3. ncbi Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation
    Laura Piccio
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 105:2421-7. 2005
  4. doi Neuronal regulation of immune responses in the central nervous system
    Li Tian
    Neuroscience Center, University of Helsinki, Viikinkaari 4, FIN 00014, Helsinki, Finland
    Trends Immunol 30:91-9. 2009
  5. ncbi CD47 in the immune response: role of thrombospondin and SIRP-alpha reverse signaling
    Marika Sarfati
    Immunoregulation Laboratory, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hôpital Notre Dame Pavillon Mailloux, M4211K, 1560 Sherbrooke Est Montreal, QC H2L4M1, Canada
    Curr Drug Targets 9:842-50. 2008
  6. pmc Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins
    E Brown
    Department of Medicine, Washington University, St Louis, Missouri 63110
    J Cell Biol 111:2785-94. 1990
  7. doi Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47
    Deborah Hatherley
    Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK
    Mol Cell 31:266-77. 2008
  8. ncbi CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis
    Laurence Lamy
    Unité INSERM 576 et Laboratoire d Immunologie, 06202 Nice Cedex 3, France
    J Biol Chem 278:23915-21. 2003
  9. ncbi Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation
    J Chung
    Department of Biochemistry and Molecular Biophysics and Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 94:642-8. 1999
  10. ncbi Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis
    Mohammad Salajegheh
    The Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, 75 Francis Street, Tower 5D, Boston, MA 02115, USA
    J Neuroimmunol 187:166-74. 2007

Research Grants

Detail Information

Publications190 found, 100 shown here

  1. ncbi CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia
    V Mateo
    Laboratoire d allergie, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, 1560 rue Sherbrooke Est, Université de Montréal H2L 4M1, Quebec, Canada
    Nat Med 5:1277-84. 1999
    ..We report here that engagement of CD47, a newly described thrombospondin receptor, by immobilized monoclonal antibody against CD47 or by thrombospondin ..
  2. ncbi C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma-chain-associated signaling pathway and by agglutination
    D Tulasne
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 98:3346-52. 2001
    ..to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47. In this study, it was discovered that 4N1-1 or its derivative peptide, 4N1K, induces rapid phosphorylation of the ..
  3. ncbi Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation
    Laura Piccio
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 105:2421-7. 2005
    ..SIRPalpha binds CD47 and inhibits the function of macrophages, dendritic cells, and granulocytes, whereas SIRPbeta1 is an orphan ..
  4. doi Neuronal regulation of immune responses in the central nervous system
    Li Tian
    Neuroscience Center, University of Helsinki, Viikinkaari 4, FIN 00014, Helsinki, Finland
    Trends Immunol 30:91-9. 2009
    ..In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity...
  5. ncbi CD47 in the immune response: role of thrombospondin and SIRP-alpha reverse signaling
    Marika Sarfati
    Immunoregulation Laboratory, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hôpital Notre Dame Pavillon Mailloux, M4211K, 1560 Sherbrooke Est Montreal, QC H2L4M1, Canada
    Curr Drug Targets 9:842-50. 2008
    ..b>CD47 and its two ligands, i.e...
  6. pmc Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins
    E Brown
    Department of Medicine, Washington University, St Louis, Missouri 63110
    J Cell Biol 111:2785-94. 1990
    ..For this reason, we call it Integrin-associated Protein (IAP). We hypothesize that IAP may play a role in signal transduction for enhanced phagocytosis by Arg-Gly-Asp ligands.
  7. doi Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47
    Deborah Hatherley
    Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK
    Mol Cell 31:266-77. 2008
    b>CD47 is a widely distributed cell-surface protein that acts a marker of self through interactions of myeloid and neural cells...
  8. ncbi CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis
    Laurence Lamy
    Unité INSERM 576 et Laboratoire d Immunologie, 06202 Nice Cedex 3, France
    J Biol Chem 278:23915-21. 2003
    b>CD47 is a surface receptor that induces either coactivation or apoptosis in lymphocytes, depending on the ligand(s) bound...
  9. ncbi Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation
    J Chung
    Department of Biochemistry and Molecular Biophysics and Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 94:642-8. 1999
    Integrin-associated protein (IAP; or CD47) is a receptor for the cell binding domain (CBD) of thrombospondin-1 (TS1)...
  10. ncbi Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis
    Mohammad Salajegheh
    The Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, 75 Francis Street, Tower 5D, Boston, MA 02115, USA
    J Neuroimmunol 187:166-74. 2007
    The TSP1/CD36/CD47-complex is involved in T cell expansion and inflammatory responses to beta-amyloid, both relevant to IBM...
  11. ncbi The SIRP family of receptors and immune regulation
    A Neil Barclay
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 6:457-64. 2006
    ..In this Review, we describe recent studies defining the ligands of the SIRP-family members, with particular emphasis on relating the molecular interactions of these proteins to their role in immune-cell regulation...
  12. doi Human thrombospondin's (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: a molecular modeling study
    Nicolas Floquet
    Institut des Biomolecules Max Mousseron, UMR 5247, CNRS Université Montpellier I Université Montpellier II, Faculte de Pharmacie, 15 rue Charles Flahault, B P 14 491, 34093 Montpellier Cedex 5, France
    Arch Biochem Biophys 478:103-9. 2008
    ..We also suggest a common opening mechanism for proteins sharing the same fold as TSP-1. This work also suggests the usefulness of our approach in other topics in which predictions of protein-protein interactions are of importance...
  13. pmc Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47
    Sukhbir Kaur
    Laboratory of Pathology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:38923-32. 2010
    ..a more potent mechanism by which TSP1 inhibits VEGF receptor-2 (VEGFR2) activation through engaging its receptor CD47. CD47 ligation is known to inhibit downstream signaling targets of VEGFR2, including endothelial nitric-oxide ..
  14. ncbi Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site
    Shyamsundar Subramanian
    Biophysical Engineering Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:1805-18. 2007
    Cell-cell interactions between ubiquitously expressed integrin-associated protein (CD47) and its counterreceptor signal regulatory protein (SIRPalpha) on phagocytes regulate a wide range of adhesive signaling processes, including the ..
  15. ncbi CD47 augments Fas/CD95-mediated apoptosis
    Partha P Manna
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:29637-44. 2005
    ..Jurkat T cells lacking CD47 (integrin-associated protein) are relatively resistant to Fas-mediated death but are efficiently killed by Fas ..
  16. ncbi Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization
    Véronique Mateo
    Centre de Recherche du Centre Hospitalier Université Montreal, Laboratoire d Immunorégulation, Universite de Montreal, Canada
    Blood 100:2882-90. 2002
    Dying cells, apoptotic or necrotic, are swiftly eliminated by professional phagocytes. We previously reported that CD47 engagement by CD47 mAb or thrombospondin induced caspase-independent cell death of chronic lymphocytic leukemic B ..
  17. ncbi Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47
    Isabelle Mouro-Chanteloup
    Institut National de la Santé et de la Recherche Médicale INSERM U76, Institut National de la Transfusion Sanguine, Paris, France
    Blood 101:338-44. 2003
    ..the linking protein(s) between the red cell skeleton and the Rh complex, we analyzed the expression of Rh, RhAG, CD47, LW, and glycophorin B proteins in red cells from patients with hereditary spherocytosis associated with complete ..
  18. ncbi Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains
    R A Rebres
    Program in Microbial Pathogenesis and Host Defense and Department of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 276:34607-16. 2001
    b>CD47 is a unique member of the Ig superfamily with a single extracellular Ig domain followed by a multiply membrane-spanning (MMS) domain with five transmembrane segments, implicated in both integrin-dependent and -independent signaling ..
  19. ncbi Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation
    S Latour
    McGill Cancer Center, McGill University and Institut de Recherches Cliniques, Montreal, Quebec, Canada
    J Immunol 167:2547-54. 2001
    ..In this study, we first show that CD47/integrin-associated protein, a ubiquitous multispan transmembrane protein highly expressed on T cells, interacts ..
  20. ncbi Integrin-associated protein (CD47) and its ligands
    E J Brown
    Program in Host Pathogen Interactions, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Cell Biol 11:130-5. 2001
    Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, ..
  21. ncbi SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages
    J F Timms
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Biol 9:927-30. 1999
    ..Other inhibitory immunoreceptors might have similar scaffold-like functions...
  22. ncbi Regulation of integrin function by CD47 ligands. Differential effects on alpha vbeta 3 and alpha 4beta1 integrin-mediated adhesion
    Heba O Barazi
    Laboratory of Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:42859-66. 2002
    We examined the regulation of alpha4beta1 integrin function in melanoma cells and T cells by ligands of CD47. A CD47 antibody (B6H12) that inhibited alphavbeta3-mediated adhesion of melanoma cells induced by CD47-binding peptides from ..
  23. ncbi Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions
    Anna M Moralez
    Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill, NC 27599, USA
    J Cell Physiol 203:328-34. 2005
    ..by which IGFBP-5 binding to TS-1 inhibited cellular responses to TS-1 plus IGF-I, TS-1 binding to integrin associated protein (IAP) was assessed. The addition of IGFBP-5 (1.0 microg/ml) inhibited TS-1-IAP association...
  24. pmc An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction
    L Erb
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Cell Biol 153:491-501. 2001
    ..by antibodies against alpha(V)beta(3)/beta(5) integrins and the integrin-associated thrombospondin receptor, CD47. Immunofluorescence of cells transfected with epitope-tagged P2Y(2)Rs indicated that alpha(V) integrins colocalized ..
  25. ncbi Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphaIIbbeta3 by its extracellular domain
    Tetsuro Takahiro Fujimoto
    Department of Hematology and Oncology, Division of Clinical Pharmacotherapeutics, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    J Biol Chem 278:26655-65. 2003
    Integrin-associated protein (IAP/CD47) is a receptor for the C-terminal cell binding domain of thrombospondin (TS)...
  26. ncbi Alpha-Pal/NRF-1 regulates the promoter of the human integrin-associated protein/CD47 gene
    Wen Teng Chang
    Institute of Basic Medical Sciences, National Cheng Kung University, Medical College, Tainan 701, Taiwan
    J Biol Chem 279:14542-50. 2004
    Integrin-associated protein (IAP or CD47) is expressed in a variety of tissues, including the nervous system and immune system...
  27. ncbi Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3
    J Chung
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:14740-6. 1997
    Integrin-associated protein (IAP or CD47) is a receptor for the cell/platelet-binding domain (CBD) of thrombospondin-1 (TS1), the most abundant protein of platelet alpha granules...
  28. ncbi Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells
    Kris Noel Dahl
    Department of Chemical and Biomolecular Engineering and School of Engineering and Applied Science, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 103:1131-6. 2004
    The reduction in expression of the integral membrane protein CD47 in human red blood cells (RBCs) deficient in protein 4.2 suggests that protein 4.2 may mediate a linkage of CD47 to the membrane skeleton...
  29. ncbi Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling
    Shyamsundar Subramanian
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood Cells Mol Dis 36:364-72. 2006
    b>Integrin Associated Protein (IAP, CD47) is a ubiquitous integral membrane protein implicated in processes (in mice) that range from inhibiting clearance by phagocytes [Oldenborg et al., Science 2000; Gardai et al...
  30. pmc Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding
    F P Lindberg
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 123:485-96. 1993
    b>Integrin Associated Protein (IAP) is a 50-kD membrane protein which copurifies with the integrin alpha v beta 3 from placenta and coimmunoprecipitates with beta 3 from platelets...
  31. pmc Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells
    Richard K Tsai
    Biophysical Engineering Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 180:989-1003. 2008
    ..cells or particles by macrophages is a rapid process that is inefficient when faced with "self" cells that display CD47-although signaling mechanisms in self-recognition have remained largely unknown...
  32. ncbi Integrin-associated protein is a ligand for the P84 neural adhesion molecule
    P Jiang
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 274:559-62. 1999
    ..Here we report that integrin-associated protein (IAP/CD47) is a predominant binding partner of P84...
  33. ncbi CD47 expression on T cell is a self-control negative regulator of type 1 immune response
    Salim Bouguermouh
    Immunoregulation, Centre Hospitalier de l Universite de Montreal, Research Center, Hospital Notre Dame, Montreal, Quebec, Canada
    J Immunol 180:8073-82. 2008
    ..Yet, the control of Th1 polarization by T cell surface molecules remains ill-defined. We here report that CD47 expression on T cells serves as a self-control mechanism to negatively regulate type 1 cellular and humoral immune ..
  34. ncbi Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interaction
    Abbe N Vallejo
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 171:1732-40. 2003
    ..from patients with rheumatoid arthritis elicit spontaneous proliferation of autologous T cells in an HLA-DR and CD47 costimulation-dependent manner...
  35. ncbi Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin
    A G Gao
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:21-4. 1996
    ..CBD of TS1 affinity label a 52-kDa cell surface glycoprotein, which we show is integrin-associated protein (IAP or CD47). IAP associates with alpha v beta 3 and thereby modulates the activity of several integrins...
  36. ncbi Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane
    A L Wu
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell 4:619-25. 1999
    Integrin-associated protein (IAP, CD47) is a plasma membrane receptor for thrombospondins and signal regulatory proteins (SIRPs) that has an essential role in host defense through its association with integrins...
  37. ncbi Evidence that muscarinic receptors in islet cells are not coupled functionally to adenylate cyclase through the inhibitory guanine nucleotide binding protein (Ni)
    M Dunlop
    University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Victoria, Australia
    Horm Metab Res 20:150-3. 1988
    ..adenylate cyclase (Ni) was investigated by the use of the Bordetella pertussis exotoxin, islet activating protein (IAP)...
  38. pmc Six areas lead national early immunization drive
    D R Woods
    Division of Immunization, Centers for Disease Control, Atlanta, GA 30333
    Public Health Rep 107:252-6. 1992
    ..The community "Immunization Action Plans" (IAP) are one of several Federal, State, and local responses to an outbreak of measles that produced 27,600 cases and 89 ..
  39. pmc Sensitivity of G-protein involved in endothelin-1-induced Ca2+ influx to pertussis toxin in porcine endothelial cells in situ
    H Aoki
    Division of Molecular Cardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 111:989-96. 1994
    ..4. Pertussis toxin (IAP) markedly inhibited the extracellular Ca2+-dependent elevation of [Ca2+]j, but had no effect on the extracellular ..
  40. ncbi Phospholipase A2-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulation
    T Nakajima
    Division of Environmental Health Research, Osaka Prefectural Institute of Public Health, 69 3, 1 chome, 537 0025, Osaka, Japan
    Int J Biochem Cell Biol 32:779-87. 2000
    ..macrophages: p-bromophenacyl bromide (pBPB) and mepacrine for PLA(2); islet-activating protein (IAP) for G-protein; H-7 for protein kinase C (PKC); AA861 for 5-lipoxygenase (5-LO); indomethacin for cyclo-oxygenase (..
  41. ncbi Cycloheximide increases endogenous retroviral RNA levels in murine liver and lung
    G Manenti
    Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan. Italy
    Tumori 75:217-21. 1989
    The expression of moloney murine leukemia virus (Mo-MuLV), intracisternal A particle (IAP), virus-like 30S sequence (VL30), early transposon (ET) endogenous retroviral sequences was analysed in the liver of untreated C3Hf, C57BL/6J and ..
  42. ncbi Indoor air quality for poor families: new evidence from Bangladesh
    S DasGupta
    Development Research Group, World Bank, Washington, DC 20433, USA
    Indoor Air 16:426-44. 2006
    ..This paper provides a detailed analysis of the implications for indoor air pollution (IAP), drawing on new 24-h monitoring data for respirable airborne particulates (PM10)...
  43. ncbi Pharmacist and physician satisfaction and rates of switching to preferred medications associated with an instant prior authorization program for proton pump inhibitors in the North Carolina Medicaid program
    Julie C Jacobson Vann
    School of Nursing, Health Care Systems, University of North Carolina at Chapel Hill, Carrington Hall, CB 7460, Chapel Hill, NC 27599 7460, USA
    J Manag Care Pharm 16:250-63. 2010
    ..Preferred PPIs included generic omeprazole and Prilosec OTC. This instant approval process (IAP) was expected to impose less administrative burden than is typically associated with PA programs by permitting ..
  44. ncbi Comparison of intrabrachial and finger blood pressure in healthy elderly volunteers
    G A Rongen
    Department of Medicine, University Hospital, Nijmegen, The Netherlands
    Am J Hypertens 8:237-48. 1995
    This study was performed to compare continuous Finapres (FIN) and intrabrachial (IAP) blood pressure in healthy elderly volunteers...
  45. ncbi Hormonal influence on lipid-protein interactions in biological membranes. Lactation effects on alkaline phosphatase activity and intestinal brush border membrane properties in rat
    A S Molina
    , , Universidad Nacional de San Luis, Argentina
    Horm Metab Res 29:159-63. 1997
    ..Our objective was to study the intestinal alkaline phosphatase (IAP) activity, lipid composition and fluidity of the proximal small intestine brush border membranes under the ..
  46. ncbi Sensitive detection of two IgG Fc receptors of mouse macrophages by chemiluminescence analysis
    T Majima
    Department of Bacteriology, Tohoku University School of Medicine, Sendai
    Immunopharmacol Immunotoxicol 11:289-307. 1989
    ..alpha A/D to the resident M phi s in vitro and the specific activation of spleen M phi FcRII by iv injection of IAP (Immunosuppressive acidic protein) into mice...
  47. pmc The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells
    X Q Wang
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Biol Cell 9:865-74. 1998
    ..Integrin-associated protein (IAP or CD47) is a receptor for the thrombospondin-1 carboxyl-terminal cell-binding domain and binds the agonist peptide 4N1K (..
  48. ncbi Comparison of different methods for measuring intra-abdominal pressure
    F F Gudmundsson
    Surgical Research Laboratory, Haukeland University Hospital, University of Bergen, 5021 Bergen, Norway
    Intensive Care Med 28:509-14. 2002
    Intra-abdominal pressure (IAP) can be measured in different ways but is usually measured indirectly via the urinary bladder...
  49. pmc Thrombospondin-1/CD47 blockade following ischemia-reperfusion injury is tissue protective
    Justin B Maxhimer
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Plast Reconstr Surg 124:1880-9. 2009
    ..following ischemia-reperfusion injury and limits nitric oxide signaling by engaging its cell surface receptor CD47. In this article, the authors examine whether postinjury blocking of this inhibitory signal can protect from ..
  50. ncbi Significance of increased neutrophils in patients with advanced colorectal cancer
    A Satomi
    Second Department of Surgery, Saitama Medical School, Japan
    Acta Oncol 34:69-73. 1995
    ..The ability to produce active oxygen and phagocytosis of neutrophils, G-CSF, sIL-2R and IAP (immunosuppressive acidic protein) were also measured...
  51. ncbi The reliability of noninvasive continuous finger blood pressure measurement in patients with both hypertension and vascular disease
    W J Bos
    Department of Internal Medicine, University of Amsterdam, The Netherlands
    Am J Hypertens 5:529-35. 1992
    ..We therefore compared Finapres blood pressure (FINAP) with intrabrachial blood pressure (IAP) responses to the Valsalva maneuver and arising in 12 patients in whom the peripheral circulation was expected to ..
  52. ncbi Correlations between cardiac output, stroke volume, central venous pressure, intra-abdominal pressure and total circulating blood volume in resuscitation of major burns
    Markus V Küntscher
    Department for Hand, Plastic and Reconstructive Surgery, Burn Center, BG, Trauma Center Ludwigshafen, Plastic and Hand Surgery, The University of Heidelberg, Berlin, Germany
    Resuscitation 70:37-43. 2006
    ..between cardiac index (CI), stroke volume index (SVI), central venous pressure (CVP), intra-abdominal pressure (IAP) and total circulating blood volume index (TBVI) during resuscitation of major burns...
  53. ncbi Early-onset group B streptococcal disease in the era of maternal screening
    Karen M Puopolo
    Department of Newborn Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 115:1240-6. 2005
    With the widespread implementation of intrapartum antibiotic prophylaxis (IAP), the rate of early-onset neonatal sepsis and meningitis caused by Streptococcus agalactiae (group B streptococcus [GBS]) has decreased dramatically, ..
  54. pmc Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathways
    Mark S Filla
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Invest Ophthalmol Vis Sci 50:5723-31. 2009
    ..CLANs form in glaucomatous and steroid-treated TM cells, which may contribute to reducing outflow facility through the TM...
  55. pmc Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses
    Jeff S Isenberg
    Laboratory of Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 284:1116-25. 2009
    Thrombospondin-1 regulates nitric oxide (NO) signaling in vascular cells via CD47. Because CD47 binding motifs are conserved in the C-terminal signature domains of all five thrombospondins and indirect evidence has implied CD47 ..
  56. ncbi [Abdominal compartment syndrome (ACS) after abdominal aortic aneurysm (AAA) open repair]
    Guido Bajardi
    Cattedra di Chirurgia Vascolare, Universita degli Studi di Palermo
    Ann Ital Chir 80:369-74. 2009
    ....
  57. ncbi Trends in sepsis-related neonatal mortality in the United States, 1985-1998
    Susan L Lukacs
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    Pediatr Infect Dis J 23:599-603. 2004
    ..In the 1990s, intrapartum antibiotic prophylaxis (IAP) was recommended to prevent maternal-infant transmission of group B Streptococcus (GBS), a leading cause of sepsis ..
  58. pmc Selective expression of intracisternal A-particle genes in established mouse plasmacytomas
    K K Lueders
    Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892
    Mol Cell Biol 13:7439-46. 1993
    Mouse plasmacytomas generally express higher levels of RNA transcripts from endogenous intracisternal A-particle (IAP) proviral elements than do lipopolysaccharide-stimulated normal lymphocytes...
  59. ncbi Serum soluble interleukin-2 receptor in colorectal cancer
    S Murakami
    Second Department of Surgery, Saitama Medical School, Japan
    Acta Oncol 33:19-21. 1994
    ..cancer, and correlated with various factors as stage, lymph node metastasis, liver metastasis, grade, serum CEA and IAP (immunosuppressive acidic protein)...
  60. ncbi The role of the intracarotid amobarbital procedure in evaluation of patients for epilepsy surgery
    D C Spencer
    Department of Neurology, Oregon Health Sciences University, Portland, USA
    Epilepsia 41:320-5. 2000
    To examine the role of the intracarotid amobarbital procedure (IAP) in the presurgical evaluation of patients with medically refractory localization-related epilepsy.
  61. ncbi Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity
    Alexandra Giatromanolaki
    Tumour and Angiogenesis Research Group, Departments of Pathology, Internal Medicine, and Radiotherapy Oncology, Democritus University of Thrace, Alexandroupolis, Greece
    Semin Oncol 29:14-21. 2002
    ..However, the mechanism of such selective action is poorly understood. Intestinal-type alkaline phosphatase (IAP) is a major isoenzyme involved in the hydrolysis of amifostine (WR-2721) to its active thiol form WR-I065...
  62. doi Effect of elevated intra-abdominal pressure on portal vein and superior mesenteric artery blood flow in a rat
    Jorge Mogilner
    Department of Pediatric Surgery, Bnai Zion Medical Center, Israel
    J Laparoendosc Adv Surg Tech A 19:S59-62. 2009
    ..It should be emphasized that elevated intra-abdominal pressure (IAP) may reduce hepatic and portal blood flow and thus may cause histologic liver damage...
  63. ncbi Differential effects of retroviral long terminal repeats on interleukin-3 gene expression and autocrine transformation
    X Y Wang
    Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina 27858, USA
    Leukemia 11:1711-25. 1997
    Previously we documented the transposition of an intracisternal A particle (IAP) provirus to the interleukin 3 (IL-3) locus which resulted in autocrine transformation...
  64. doi Changes in intra-abdominal pressure and spontaneous breath volume by magnitude of lifting effort: highly trained athletes versus healthy men
    Masashi Kawabata
    National Institute of Fitness and Sports, 1 Shiromizu, Kanoya, Kagoshima 891 2393, Japan
    Eur J Appl Physiol 109:279-86. 2010
    Intra-abdominal pressure (IAP) is closely related to breathing behavior during lifting. Abdominal muscles contribute to both IAP development and respiratory function...
  65. ncbi Interaction of guanine-nucleotide-binding regulatory proteins with chemotactic peptide receptors in differentiated human leukemic HL-60 cells
    M Tohkin
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    Eur J Biochem 195:527-33. 1991
    ..regulatory proteins (G proteins) serving as the substrate for pertussis toxin (islet-activating protein; IAP) were extracted from cell membranes then reconstituted into phospholipid vesicles...
  66. doi Influence of increased intra-abdominal pressure on fluid responsiveness predicted by pulse pressure variation and stroke volume variation in a porcine model
    Jochen Renner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Crit Care Med 37:650-8. 2009
    ..The influence of increased intra-abdominal pressure (IAP) on the predictive ability of these variables is currently under debate...
  67. ncbi Can the Wada test evaluate mesial temporal function? A SPECT study
    X Setoain
    Department of Nuclear Medicine, Hospital Clinic of Barcelona, University of Barcelona, Spain
    Neurology 62:2241-6. 2004
    To assess the value of SPECT during intracarotid amobarbital procedure (IAP) to discriminate which patients performed the test with the hippocampus inactivated and correlate it with the risk of amnesia after anterior temporal lobectomy (..
  68. ncbi Preoperative pain and medications used in emergency patients with irreversible acute pulpitis or acute apical periodontitis: a prospective comparative study
    Babacar Touré
    Department of Conservative Dentistry and Endodontics, Faculty of Medicine, Pharmacy, and Dentistry, University Cheikh Anta Diop, Dakar, Senegal
    J Orofac Pain 21:303-8. 2007
    To determine the pain characteristics of and medications used for patients seeking emergency care for irreversible acute pulpitis (IAP) or acute apical periodontitis (AAP).
  69. pmc Amsacta moorei Entomopoxvirus inhibitor of apoptosis suppresses cell death by binding Grim and Hid
    Qianjun Li
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Box 100266, Gainesville, FL 32610 0266, USA
    J Virol 79:3684-91. 2005
    Inhibitor of apoptosis (iap) genes have been identified in the genomes of two independent families of insect viruses, the Baculoviridae and the Entomopoxvirinae...
  70. pmc Intra-abdominal pressure alterations after large pancreatic pseudocyst transcutaneous drainage
    Theodossis S Papavramidis
    1st Propedeutic Department of Surgery, AHEPA University Hospital, Aristotle s University of Thessaloniki, Macedonia, Greece
    BMC Gastroenterol 9:42. 2009
    ..Aims of the present study were to evaluate the intra-abdominal pressure (IAP) induced by large pancreatic pseudocysts and to examine the effect of their transcutaneous drainage on IAP.
  71. pmc Comparison of virulence plasmids among Clostridium perfringens type E isolates
    Jihong Li
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Infect Immun 75:1811-9. 2007
    Clostridium perfringens type E isolates produce iota-toxin, which is encoded by iap and ibp genes...
  72. ncbi [Effects of early goal-directed fluid therapy on intra-abdominal hypertension and multiple organ dysfunction in patients with severe acute pancreatitis.]
    Zhi Yong Yang
    Pancreatic Surgery, Union Hospital, Affiliated Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Wai Ke Za Zhi 47:1450-4. 2009
    ..To observe the effects of early goal-directed fluid therapy with hydroxyethyl starch 130/0.4 on intra-abdominal hypertension (IAH), multiple organ dysfunction and fluid balance in severe acute pancreatitis (SAP) patients...
  73. ncbi Interpretation of EMG changes with fatigue: facts, pitfalls, and fallacies
    N A Dimitrova
    Centre of Biomedical Engineering, Bulgarian Academy of Sciences, Acad G Bonchev Str, Bl 105, 1113, Sofia, Bulgaria
    J Electromyogr Kinesiol 13:13-36. 2003
    ..for pitfalls and fallacies in analysis of experimental results if changes in intracellular action potential (IAP), i.e. in peripheral factors of muscle fatigue, were not taken into consideration...
  74. ncbi Continuous negative abdominal pressure device to treat pseudotumor cerebri
    H J Sugerman
    Department of Surgery, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia, USA
    Int J Obes Relat Metab Disord 25:486-90. 2001
    To study the effects of an externally applied negative abdominal pressure device designed to lower the effects of intra-abdominal pressure (IAP) on headaches and pulsatile tinnitus in severely obese women with pseudotumor cerebri (PTC).
  75. pmc Pilot testing of WHO child growth standards in Chandigarh: implications for India's child health programmes
    Shankar Prinja
    Postgraduate Institute of Medical Education and Research, School of Public Health, Chandigarh, India
    Bull World Health Organ 87:116-22. 2009
    To compare the prevalence of underweight as calculated from Indian Academy of Paediatrics (IAP) growth curves (based on the Harvard scale) and the new WHO Child Growth Standards.
  76. ncbi Evaluation of a method for measuring tissue non-specific alkaline phosphatase activity in healthy subjects
    Makoto Matsushita
    Department of Clinical Chemistry, Saitama Prefectural University, 820 Sannomiya, Koshigaya 343 8540, Japan
    Ann Clin Biochem 44:544-8. 2007
    Intestinal alkaline phosphatase (IAP) isozymes in the healthy human serum samples appears in two isoforms: normal-molecular-weight IAP (NIAP) and high-molecular-weight IAP (HIAP)...
  77. ncbi Health benefits from reducing indoor air pollution from household solid fuel use in China--three abatement scenarios
    Heidi Elizabeth Staff Mestl
    Center for International Climate and Environmental Research, P O Box 1129 Blindern, N 0318 Oslo, Norway
    Environ Int 33:831-40. 2007
    According to the World Health Organization (WHO), indoor air pollution (IAP) from the use of solid fuels in households in the developing world is responsible for more than 1.6 million premature deaths each year, whereof 0...
  78. doi Effects of norepinephrine during intra-abdominal hypertension on renal blood flow in bacteremic dogs
    Zhi Y Peng
    Chinese University of Hong Kong, Hong Kong, China
    Crit Care Med 36:834-41. 2008
    ..The effects of intra-abdominal pressure (IAP), followed by restoration of APP with norepinephrine, on renal blood flow were determined.
  79. ncbi Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons
    Hiroshi Ohnishi
    Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371 8512, Japan
    J Neurosci 25:2702-11. 2005
    ..protein tyrosine phosphatase (SHP) substrate-1 (SHPS-1) and its ligand cluster of differentiation 47 (CD47), both of which are members of the Ig superfamily of proteins, are thought to constitute an intercellular ..
  80. doi Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)
    John W Blankenship
    Department of Protein Engineering, Genentech, Inc, 1 DNA Way, M S 40, South San Francisco, CA 94080, USA
    Biochem J 417:149-60. 2009
    A family of anti-apoptotic regulators known as IAP (inhibitor of apoptosis) proteins interact with multiple cellular partners and inhibit apoptosis induced by a variety of stimuli...
  81. doi Effect of elevated intra-abdominal pressure and 100% oxygen on superior mesenteric artery blood flow and enterocyte turnover in a rat
    Igor Sukhotnik
    Department of Pediatric Surgery B, Bnai Zion Medical Center, 47 Golomb St, P O B 4940, 31048, Haifa, Israel
    Pediatr Surg Int 24:1347-53. 2008
    Elevated intra-abdominal pressure (IAP) has been shown to reduce mesenteric blood flow and cause intestinal damage...
  82. doi Activation of CD47 receptors causes proliferation of human astrocytoma but not normal astrocytes via an Akt-dependent pathway
    Emilie Sick
    Universite de Strasbourg, CNRS UMR 7213 Pharmacologie, Faculte de Pharmacie, 74 rte du Rhin, Illkirch, France
    Glia 59:308-19. 2011
    b>CD47 is a membrane receptor that plays pivotal roles in many pathophysiological processes, including infection, inflammation, cell spreading, proliferation, and apoptosis...
  83. ncbi Laparoscopic spray application of fibrin sealant effects on hemodynamics and spray efficiency at various application pressures and distances
    K T Druckrey-Fiskaaen
    Department of Visceral, Transplantation, Thoracic, and Vascular Surgery, Universitat Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany
    Surg Endosc 21:1750-9. 2007
    Laparoscopic resections of parenchymal organs are increasingly performed. However, little is known about the effects of laparoscopic fibrin sealant spray applications on intraabdominal pressure (IAP) and hemodynamics.
  84. ncbi Adverse effects of pneumoperitoneum on renal function: involvement of the endothelin and nitric oxide systems
    Zaid Abassi
    Department of Physiology and Biophysics, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Isarel Institute of Technology, Haifa, 31096, Israel
    Am J Physiol Regul Integr Comp Physiol 294:R842-50. 2008
    Increased intra-abdominal pressure (IAP) during laparoscopy adversely affects kidney function. The mechanism underlying this phenomenon is largely unknown...
  85. pmc CD47 gene knockout protects against transient focal cerebral ischemia in mice
    Guang Jin
    Department of Radiology and Neurology, Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Massachusetts 02129, USA
    Exp Neurol 217:165-70. 2009
    b>CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels. The present study was performed to determine whether absence of the CD47 gene decreases focal ischemic brain damage...
  86. doi Possible importance of increased intra-abdominal pressure for the development of necrotizing enterocolitis
    I Sukhotnik
    The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Laboratory of Intestinal Adaptation and Recovery, Dept of Pediatric Surgery, Bnai Zion Medical Center, Haifa, Israel
    Eur J Pediatr Surg 19:307-10. 2009
    ..In the present work we describe 5 neonates with NEC in whom intra-abdominal pressure (IAP) was measured to investigate the potential role of abdominal compartment syndrome (ACS) in the development of NEC ..
  87. pmc Situational analysis of household energy and biomass use and associated health burden of indoor air pollution and mitigation efforts in Pakistan
    Zafar Fatmi
    Division of Environmental Health Sciences, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Int J Environ Res Public Health 7:2940-52. 2010
    ..the indoor environment in countries where it is in common use, contributing significantly to indoor air pollution (IAP)...
  88. ncbi Intestinal alkaline phosphatase secretion in oil-fed rats
    Jyotdeep Kaur
    Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India
    Dig Dis Sci 52:665-70. 2007
    Oil feeding is known to increase the secretion of intestinal alkaline phosphatase (IAP) into serum and this phenomenon is shown to be mediated by surfactant-like particles...
  89. doi Accuracy of physical examination and intra-access pressure in the detection of stenosis in hemodialysis arteriovenous fistula
    Rodrigo Peixoto Campos
    Division of Interventional and Critical Care Nephrology, Hospital Universitario Evangelico de Curitiba, Curitiba, Brazil
    Semin Dial 21:269-73. 2008
    Both physical examination (PE) and intra-access pressure (IAP) measurements have been used in the identification of stenosis in an arteriovenous access...
  90. pmc Gene silencing of CD47 and antibody ligation of thrombospondin-1 enhance ischemic tissue survival in a porcine model: implications for human disease
    Jeff S Isenberg
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Ann Surg 247:860-8. 2008
    ..Recently, we reported that the secreted protein thrombospondin-1 (TSP1), through its cell surface receptor CD47, limits the ability of NO to relax and dilate blood vessels and thus decreases tissue perfusion...
  91. ncbi Direct comparison of local cerebral blood flow rates measured by MRI arterial spin-tagging and quantitative autoradiography in a rat model of experimental cerebral ischemia
    James R Ewing
    Department of Neurology and Center for Stroke Research, Henry Ford Hospital and Health Science Center, Detroit, Michigan 48202, USA
    J Cereb Blood Flow Metab 23:198-209. 2003
    ..using two different magnetic resonance imaging (MRI) arterial spin-tagging (AST) methods and 14C-iodoantipyrine (IAP)-quantitative autoradiography (QAR), a standard but terminal technique used for imaging and quantitating CBF, and ..
  92. ncbi The inhibitors of apoptosis of Epiphyas postvittana nucleopolyhedrovirus
    T Maguire
    Department of Microbiology, School of Medical Sciences, University of Otago, PO Box 56, Dunedin, New Zealand
    J Gen Virol 81:2803-11. 2000
    ..apoptosis genes (iaps) in the genome of Epiphyas postvittana nucleopolyhedrovirus (EppoMNPV) that are homologous to iap-1, iap-2, iap-3 and iap-4 genes of other baculoviruses have been identified...
  93. ncbi Ileoanal pouch operation: long-term outcome with or without diverting ileostomy
    P M Mowschenson
    Beth Israel Deaconess Medical Center, Center for Inflammatory Bowel Disease, Harvard Medical School, Boston, Mass, USA
    Arch Surg 135:463-5; discussion 465-6. 2000
    Avoiding a diverting ileostomy does not influence the long-term overall morbidity and functional outcome of patients after ileoanal pouch operation (IAP).
  94. doi Open reading frame 193R of Chilo iridescent virus encodes a functional inhibitor of apoptosis (IAP)
    Ikbal Agah Ince
    Department of Biology, Faculty of Arts and Sciences, Karadeniz Technical University, 61080, Trabzon, Turkey
    Virology 376:124-31. 2008
    ..The genome of Chilo iridescent virus (CIV) has three ORFs with homology to baculovirus inhibitor of apoptosis (iap) genes. The proteins encoded by the 157L, 193R, and 332L ORFs contain 152, 208 and 234 amino acids, respectively...
  95. doi Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis
    Muhittin Tasdogan
    Department of Anaesthesiology and Reanimation, Trakya University Medical Faculty, 22030 Edirne, Turkey
    J Clin Anesth 21:394-400. 2009
    ..of propofol and the alpha-2 adrenoceptor, dexmedetomidine, on inflammatory responses and intraabdominal pressure (IAP) in severe sepsis after abdominal surgery, specifically, serum cytokine levels (interleukin [IL]-1, IL-6, and tumor ..
  96. ncbi Effects of intra-abdominal CO2-insufflation on normal and impaired myocardial function: an experimental study
    C A Greim
    Klinik fur Anaesthesiologie, Universitatsklinikum Wurzburg, Germany
    Acta Anaesthesiol Scand 47:751-60. 2003
    Intra-abdominal pressure (IAP) elevation during CO2-pneumoperitoneum increases cardiac afterload and may enhance dysfunction of the already compromised heart...
  97. ncbi An abundant placental transcript containing an IAP-LTR is allelic to mouse pregnancy-specific glycoprotein 23 (Psg23): cloning and genetic analysis
    Melanie Ball
    Department of Biochemistry, Biosciences Institute, University College Cork, College Road, Cork, Ireland
    Gene 325:103-13. 2004
    ..In addition to the 7 kb full-length type I and 5 kb type I deleted intracisternal A-particle (IAP) transcripts, we identified and cloned an abundant 2 kb transcript encoding a novel member of the pregnancy-..
  98. pmc Decreased CD47 expression during spontaneous apoptosis targets neutrophils for phagocytosis by monocyte-derived macrophages
    Donald W Lawrence
    Department of Pediatrics, Division of Neonatology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Early Hum Dev 85:659-63. 2009
    ..Efficient phagocytosis of apoptotic neutrophils is necessary for successful resolution. CD47 plays a critical role in mediating the phagocytic response, although its role in the phagocytosis of apoptotic PMN ..
  99. pmc Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding
    F P Lindberg
    Department of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 134:1313-22. 1996
    Integrin-associated protein (IAP/CD47) is physically associated with the alpha v beta 3 vitronectin (Vn) receptor and a functionally and immunologically related integrin on neutrophils (PMN) and monocytes...
  100. doi CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fcgamma receptor-mediated but not scavenger receptor-mediated recognition by macrophages
    Mattias Olsson
    Department of Integrative Medical Biology, Umea University, Umea, Sweden
    Blood 112:4259-67. 2008
    b>CD47 functions as a marker of self on red blood cells (RBCs) by binding to signal regulatory protein alpha on macrophages, preventing phagocytosis of autologous RBCs by splenic red pulp macrophages, and Fcgamma receptor (FcgammaR)- or ..
  101. ncbi [Measurement of the intra abdominal pressure in clinical practice]
    Dariusz Onichimowski
    Oddział Anestezjologii i Intensywnej Terapii, Wojewódzki Szpital Specjalistyczny w Olsztynie
    Anestezjol Intens Ter 42:107-12. 2010
    ..Intra-abdominal pressure (IAP) has been defined as a static pressure between organs in the abdominal cavity...

Research Grants74

  1. Role of CD47 in xenograft rejection by macrophages
    Yong Guang Yang; Fiscal Year: 2010
    ..b>CD47 is ubiquitously expressed and serves as a ligand of signal regulatory protein (SIRP)1, a key inhibitory receptor on ..
  2. Mechanisms of Microglial Activation and Phagocytosis in*
    Gary Landreth; Fiscal Year: 2005
    ..We will cross mice overexpressing the human APP gene with animals in which the integrin-associated protein (IAP)/CD47, the B-class scavenger receptor CD36, or complement receptor CD18 genes have been knocked out, and seek to ..
  3. Urokinase, Neutrophil Activation and Acute Lung Injury.
    Edward Abraham; Fiscal Year: 2010
    ..the expression of receptors and ligands involved in phagocytosis of neutrophils, including calreticulin (CRT), CD47, CD31, integrins, mer, axl, and LRP, as well as in affecting the binding of opsonins to PtdSer and of collectins to ..
  4. Role of CD47 in xenograft rejection by macrophages
    Yong Guang Yang; Fiscal Year: 2011
    ..b>CD47 is ubiquitously expressed and serves as a ligand of signal regulatory protein (SIRP)1, a key inhibitory receptor on ..
  5. Role of CD47 in xenograft rejection by macrophages
    Yong Guang Yang; Fiscal Year: 2009
    ..b>CD47 is ubiquitously expressed and serves as a ligand of signal regulatory protein (SIRP)1, a key inhibitory receptor on ..
  6. Heat Shock-Induced Apoptosis
    Shawn B Bratton; Fiscal Year: 2010
    ..MOMP is critical for cell death most likely because it facilitates the release of inhibitor of apoptosis (IAP) antagonists, which in turn promote caspase activity...
  7. ADPKD: Understanding mechanisms, Discovering treatments.
    Xiaogang Li; Fiscal Year: 2010
    ..The inhibitor of apoptosis (IAP) antagonist, Smac-mimetic, is able to target the above TNF??-mediated complexes to induce cancer cell death...
  8. CD47 as a neurovascular target for stroke therapy
    ENG LO; Fiscal Year: 2007
    ..Here, we propose that the transmembrane receptor CD47 (also known as integrin associated protein) may be an ideal neurovascular target for stroke therapy...
  9. CD47 as a neurovascular target for stroke therapy
    Eng H Lo; Fiscal Year: 2010
    ..Here, we propose that the transmembrane receptor CD47 (also known as integrin associated protein) may be an ideal neurovascular target for stroke therapy...
  10. REGULATION OF CELL DEATH IN DROSOPHILA
    Bruce Hay; Fiscal Year: 2002
    ..The Inhibitor of Apoptosis (IAP) family of proteins, originally identified as baculovirus encoded inhibitors of a host suicide response, are an ..
  11. SPECTRIN EXTENSIBILITY and CD47 CONNECTIONS & FUNCTION
    Dennis Discher; Fiscal Year: 2007
    ..2 - a major fraction of the integral membrane protein CD47, at least in human RBC...
  12. Is Aberrant MO Stimulation Pivotal in Post-Trauma MODS?
    Carol L Miller Graziano; Fiscal Year: 2010
    ..bacteremia with 1) MO that express a unique cohorts of interactive, inhibitory mediators/receptors including TSP-1, CD47, SIRP1, 2) inhibitory DC with low costimulatory receptors increased coinhibitory receptors &altered mediators (..
  13. Is Aberrant MO Stimulation Pivotal in Post-Trauma MODS?
    Carol Miller Graziano; Fiscal Year: 2009
    ..bacteremia with 1) MO that express a unique cohorts of interactive, inhibitory mediators/receptors including TSP-1, CD47, SIRP1, 2) inhibitory DC with low costimulatory receptors increased coinhibitory receptors & altered mediators (..
  14. Is Aberrant MO Stimulation Pivotal in Post-Trauma MODS?
    Carol Miller Graziano; Fiscal Year: 2009
    ..bacteremia with 1) MO that express a unique cohorts of interactive, inhibitory mediators/receptors including TSP-1, CD47, SIRP1, 2) inhibitory DC with low costimulatory receptors increased coinhibitory receptors & altered mediators (..
  15. Is Aberrant MO Stimulation Pivotal in Post-Trauma MODS?
    Carol L Miller Graziano; Fiscal Year: 2011
    ..bacteremia with 1) MO that express a unique cohorts of interactive, inhibitory mediators/receptors including TSP-1, CD47, SIRP1, 2) inhibitory DC with low costimulatory receptors increased coinhibitory receptors &altered mediators (..
  16. Role of Beta 3 Integrin in Skeletal Metastasis
    KATHERINE NELSON WEILBAECHER; Fiscal Year: 2010
    ..we will investigate the roles of the 3 integrin activating receptor, P2Y12, and a 3-integrin stimulating protein, CD47, on platelet and osteoclast function and during bone metastasis...
  17. Studies of Erythrocyte Membrane Structure
    Philip Low; Fiscal Year: 2009
    ..transport across the membrane, but also organizes a complex of membrane-spanning proteins, including glycophorin A, CD47, Rh proteins, aquaporin, and several transporters...
  18. Studies of Erythrocyte Membrane Structure
    Philip Stewart Low; Fiscal Year: 2010
    ..transport across the membrane, but also organizes a complex of membrane-spanning proteins, including glycophorin A, CD47, Rh proteins, aquaporin, and several transporters...
  19. Control of Trabecular Meshwork Cytoskeleton
    DONNA PETERS; Fiscal Year: 2009
    ..These studies indicated that both 23 integrins and CD47, a member of both the IgG superfamily and the G-protein- coupled receptor family, may be part of the signaling ..
  20. Progression of Metastasis of Oral Tongue Cancer
    Jeffrey Myers; Fiscal Year: 2007
    ..The third hypothesis is that the BiR containing proteins c-IAP-2, survivin, and XIAP are mediating the detachment-induced survival in the face of multiple forms of apoptotic ..