CD46

Summary

Gene Symbol: CD46
Description: CD46 molecule
Alias: AHUS2, MCP, MIC10, TLX, TRA2.10, membrane cofactor protein, CD46 antigen, complement regulatory protein, CD46 molecule, complement regulatory protein, antigen identified by monoclonal antibody TRA-2-10, complement membrane cofactor protein, measles virus receptor, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), trophoblast leucocyte common antigen, trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen
Species: human
Products:     CD46

Top Publications

  1. Dörig R, Marcil A, Chopra A, Richardson C. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell. 1993;75:295-305 pubmed
    ..A study of lymphocyte markers suggested that the complement regulator known either as membrane cofactor protein or CD46 was the measles virus receptor...
  2. Källström H, Liszewski M, Atkinson J, Jonsson A. Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. Mol Microbiol. 1997;25:639-47 pubmed
    ..This is a migration pattern typical of membrane cofactor protein (MCP or CD46). MCP is a widely distributed human complement regulatory protein...
  3. Warwicker P, Goodship T, Donne R, Pirson Y, Nicholls A, Ward R, et al. Genetic studies into inherited and sporadic hemolytic uremic syndrome. Kidney Int. 1998;53:836-44 pubmed
    ..In light of these findings and previous reports of HUS in patients with factor H deficiency, we postulate that abnormalities of factor H may be involved in the etiology of HUS. ..
  4. Santoro F, Kennedy P, Locatelli G, Malnati M, Berger E, Lusso P. CD46 is a cellular receptor for human herpesvirus 6. Cell. 1999;99:817-27 pubmed
    ..Here, we show that the two major HHV-6 subgroups (A and B) use human CD46 as a cellular receptor. Downregulation of surface CD46 was documented during the course of HHV-6 infection...
  5. Wang G, Liszewski M, Chan A, Atkinson J. Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation. J Immunol. 2000;164:1839-46 pubmed
    b>Membrane cofactor protein (MCP; CD46) is a widely expressed type 1 transmembrane glycoprotein that inhibits complement activation on host cells...
  6. Joubert P, Meiffren G, Gregoire I, Pontini G, Richetta C, Flacher M, et al. Autophagy induction by the pathogen receptor CD46. Cell Host Microbe. 2009;6:354-66 pubmed publisher
    ..We report here that the engagement of CD46, a ubiquitous human surface receptor able to bind several different pathogens, is sufficient to induce autophagy...
  7. Fuchs A, Atkinson J, Fremeaux Bacchi V, Kemper C. CD46-induced human Treg enhance B-cell responses. Eur J Immunol. 2009;39:3097-109 pubmed publisher
    ..be induced by the concomitant stimulation of human CD4(+) T cells through CD3 and the membrane complement regulator CD46. These complement (CD46)-induced regulatory T cells (cTreg) potently inhibit bystander T-cell proliferation through ..
  8. Fang C, Fremeaux Bacchi V, Liszewski M, Pianetti G, Noris M, Goodship T, et al. Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. Blood. 2008;111:624-32 pubmed
    ..Genetic studies demonstrate that heterozygous mutations of membrane cofactor protein (MCP;CD46) predispose to atypical HUS (aHUS), which is not associated with exposure to Shiga toxin (Stx)...
  9. Kemper C, Chan A, Green J, Brett K, Murphy K, Atkinson J. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature. 2003;421:388-92 pubmed
    ..Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4+ T cells...

More Information

Publications81

  1. Casasnovas J, Larvie M, Stehle T. Crystal structure of two CD46 domains reveals an extended measles virus-binding surface. EMBO J. 1999;18:2911-22 pubmed
    ..The cell surface receptor for measles virus in humans is CD46, a complement cofactor. We report here the crystal structure at 3...
  2. Mori Y, Seya T, Huang H, Akkapaiboon P, Dhepakson P, Yamanishi K. Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46. J Virol. 2002;76:6750-61 pubmed
    ..Furthermore, the fusion event was dependent on the expression of the HHV-6 entry receptor, CD46, on the target cell membrane...
  3. Johansson L, Rytkonen A, Bergman P, Albiger B, Källström H, Hokfelt T, et al. CD46 in meningococcal disease. Science. 2003;301:373-5 pubmed
    ..The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation...
  4. Marie J, Astier A, Rivailler P, Rabourdin Combe C, Wild T, Horvat B. Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation. Nat Immunol. 2002;3:659-66 pubmed
    b>CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products...
  5. Lublin D, Liszewski M, Post T, Arce M, Le Beau M, Rebentisch M, et al. Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins. J Exp Med. 1988;168:181-94 pubmed
    b>Membrane cofactor protein (MCP), a regulatory molecular of the complement system with cofactor activity for the factor I-mediated inactivation of C3b and C4b, is widely distributed, being present on leukocytes, platelets, endothelial ..
  6. Weyand N, Calton C, Higashi D, Kanack K, So M. Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection. J Immunol. 2010;184:694-701 pubmed publisher
    b>CD46 is a type I transmembrane protein with complement and T cell regulatory functions in human cells...
  7. Ni Choileain S, Weyand N, Neumann C, Thomas J, So M, Astier A. The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation. PLoS ONE. 2011;6:e16287 pubmed publisher
    Adequate termination of an immune response is as important as the induction of an appropriate response. CD46, a regulator of complement activity, promotes T cell activation and differentiation towards a regulatory Tr1 phenotype...
  8. Okada N, Liszewski M, Atkinson J, Caparon M. Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc Natl Acad Sci U S A. 1995;92:2489-93 pubmed
    ..b>Membrane cofactor protein (MCP), or CD46, is a short consensus repeat-containing protein found on the surface of keratinocytes, ..
  9. Csomor P, Szalmás A, Konya J, Sziklai I, Karosi T. Restriction analysis of otosclerosis-associated CD46 splicing variants. Eur Arch Otorhinolaryngol. 2010;267:219-26 pubmed publisher
    ..The human cellular receptor of measles virus is the membrane cofactor protein (MCP, CD46), which has 14 well-described splicing variants...
  10. Le Friec G, Sheppard D, Whiteman P, Karsten C, Shamoun S, Laing A, et al. The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol. 2012;13:1213-21 pubmed publisher
    b>CD46 is a complement regulator with important roles related to the immune response...
  11. Alford S, Longmore G, Stenson W, Kemper C. CD46-induced immunomodulatory CD4+ T cells express the adhesion molecule and chemokine receptor pattern of intestinal T cells. J Immunol. 2008;181:2544-55 pubmed
    ..Activation of human primary CD4(+) T cells in the presence of CD46 cross-linking induces the development of a distinct immunomodulatory T cell population characterized by high IL-10/..
  12. Astier A, Trescol Biemont M, Azocar O, Lamouille B, Rabourdin Combe C. Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation. J Immunol. 2000;164:6091-5 pubmed
    The widely expressed transmembrane molecule CD46 is the complement regulatory receptor for C3b as well as the receptor for several pathogens. Beside its binding functions, CD46 is also able to transduce signals...
  13. Post T, Liszewski M, Adams E, Tedja I, Miller E, Atkinson J. Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype. J Exp Med. 1991;174:93-102 pubmed
    b>Membrane cofactor protein (MCP) is a complement regulatory protein that is expressed on human cells and cell lines as two relatively broad species with Mr of 58,000-68,000 and 48,000-56,000...
  14. Meiffren G, Flacher M, Azocar O, Rabourdin Combe C, Faure M. Cutting edge: abortive proliferation of CD46-induced Tr1-like cells due to a defective Akt/Survivin signaling pathway. J Immunol. 2006;177:4957-61 pubmed
    T regulatory cell 1 (Tr1) are low proliferating peripherally induced suppressive T cells. Engaging CD3 and CD46 on human CD4+ T cells induces a Tr1-like phenotype...
  15. Richards A, Kemp E, Liszewski M, Goodship J, Lampe A, Decorte R, et al. Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Proc Natl Acad Sci U S A. 2003;100:12966-71 pubmed
    b>Membrane cofactor protein (MCP; CD46) is a widely expressed transmembrane complement regulator. Like factor H it inhibits complement activation by regulating C3b deposition on targets...
  16. Källström H, Blackmer Gill D, Albiger B, Liszewski M, Atkinson J, Jonsson A. Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence. Cell Microbiol. 2001;3:133-43 pubmed
    Pili of Neisseria gonorrhoeae mediate binding of the bacteria to human host cells. Membrane cofactor protein (MCP or CD46), a human cell-surface protein involved in regulation of complement activation, acts as a cellular pilus receptor...
  17. Noris M, Brioschi S, Caprioli J, Todeschini M, Bresin E, Porrati F, et al. Familial haemolytic uraemic syndrome and an MCP mutation. Lancet. 2003;362:1542-7 pubmed
    ..genes that encode the complement regulatory proteins-ie, factor H related 5, complement receptor 1, and membrane cofactor protein (MCP)-by PCR-single-strand conformation polymorphism (PCR-SSCP) and by direct sequencing, in 25 ..
  18. Couzi L, Contin Bordes C, Marliot F, Sarrat A, Grimal P, Moreau J, et al. Inherited deficiency of membrane cofactor protein expression and varying manifestations of recurrent atypical hemolytic uremic syndrome in a sibling pair. Am J Kidney Dis. 2008;52:e5-9 pubmed publisher
    ..Complement factor H (CFH), factor I, and membrane cofactor protein (MCP; CD46), 3 regulators of the alternative pathway of the complement system activation, have been ..
  19. Oliaro J, Pasam A, Waterhouse N, Browne K, Ludford Menting M, Trapani J, et al. Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation. Proc Natl Acad Sci U S A. 2006;103:18685-90 pubmed
    ..We investigated the effect of ligation of the immunoregulatory cell surface receptor, CD46, on lymphocyte polarity during antigen presentation and cytotoxic effector function...
  20. Hakulinen J, Keski Oja J. ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells. J Biol Chem. 2006;281:21369-76 pubmed
    b>Membrane cofactor protein CD46 controls complement activation on cells, is a receptor for several pathogens, and modulates immune responses by affecting CD8(+) T cells...
  21. Caprioli J, Noris M, Brioschi S, Pianetti G, Castelletti F, Bettinaglio P, et al. Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome. Blood. 2006;108:1267-79 pubmed
    ..We undertook genetic analysis on membrane cofactor protein (MCP), complement factor H (CFH), and factor I (IF) in 156 patients with non-Stx-HUS...
  22. Fremeaux Bacchi V, Kemp E, Goodship J, Dragon Durey M, Strain L, Loirat C, et al. The development of atypical haemolytic-uraemic syndrome is influenced by susceptibility factors in factor H and membrane cofactor protein: evidence from two independent cohorts. J Med Genet. 2005;42:852-6 pubmed
    ..have been reported in regulators of the alternative complement pathway including factor H (CFH), membrane cofactor protein (MCP), and the serine protease factor I (IF)...
  23. Crimeen Irwin B, Ellis S, Christiansen D, Ludford Menting M, Milland J, Lanteri M, et al. Ligand binding determines whether CD46 is internalized by clathrin-coated pits or macropinocytosis. J Biol Chem. 2003;278:46927-37 pubmed
    b>CD46 is a ubiquitous human cell surface receptor for the complement components C3b and C4b and for various pathogens, including the measles virus and human herpes virus 6...
  24. Manchester M, Valsamakis A, Kaufman R, Liszewski M, Alvarez J, Atkinson J, et al. Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46). Proc Natl Acad Sci U S A. 1995;92:2303-7 pubmed
    The human complement regulatory protein membrane cofactor protein (CD46) is the cellular receptor for measles virus (MV), whereas decay accelerating factor (DAF; CD55), a structurally similar complement regulatory protein, does not bind ..
  25. Riley R, Kemper C, Leung M, Atkinson J. Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa. Mol Reprod Dev. 2002;62:534-46 pubmed
    b>Membrane cofactor protein (MCP; CD46) is a complement regulator widely expressed as four isoforms that arise via alternative splicing...
  26. Lee S, Bonnah R, Higashi D, Atkinson J, Milgram S, So M. CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. J Cell Biol. 2002;156:951-7 pubmed
    The Neisseria type IV pilus promotes bacterial adhesion to host cells. The pilus binds CD46, a complement-regulatory glycoprotein present on nucleated human cells (Källström et al., 1997)...
  27. Ghannam A, Fauquert J, Thomas C, Kemper C, Drouet C. Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation. Mol Immunol. 2014;58:98-107 pubmed publisher
    ..For example, engagement of the complement regulator CD46 by its ligand C3b generated upon TCR activation is required for IFN-? production as CD46-deficient patients lack ..
  28. Ludford Menting M, Thomas S, Crimeen B, Harris L, Loveland B, Bills M, et al. A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization. J Biol Chem. 2002;277:4477-84 pubmed
    Using a yeast two-hybrid screen, we identified a physical interaction between CD46 and DLG4. CD46 is a ubiquitous human cell-surface receptor for the complement components C3b and C4b and for measles virus and human herpesvirus 6...
  29. Moore I, Strain L, Pappworth I, Kavanagh D, Barlow P, Herbert A, et al. Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome. Blood. 2010;115:379-87 pubmed publisher
    ..In 5 patients mutations were identified: 1 in CFH, 1 in CFI, 1 in CD46, and 2 in C3...
  30. Crawford D, Zimmer S, Morin C, Messonnier N, Lynfield R, Yi Q, et al. Integrating host genomics with surveillance for invasive bacterial diseases. Emerg Infect Dis. 2008;14:1138-40 pubmed publisher
    ..Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to ..
  31. Barilla LaBarca M, Liszewski M, Lambris J, Hourcade D, Atkinson J. Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol. 2002;168:6298-304 pubmed
    C4b and C3b deposited on host cells undergo limited proteolytic cleavage by regulatory proteins. Membrane cofactor protein (MCP; CD46), factor H, and C4b binding protein mediate this reaction, known as cofactor activity, that also ..
  32. Zaffran Y, Destaing O, Roux A, Ory S, Nheu T, Jurdic P, et al. CD46/CD3 costimulation induces morphological changes of human T cells and activation of Vav, Rac, and extracellular signal-regulated kinase mitogen-activated protein kinase. J Immunol. 2001;167:6780-5 pubmed
    ..We recently showed that CD46, a complement regulatory receptor for C3b as well as a receptor for several pathogens, could act as a potent ..
  33. Naniche D, Varior Krishnan G, Cervoni F, Wild T, Rossi B, Rabourdin Combe C, et al. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J Virol. 1993;67:6025-32 pubmed
    ..glycoprotein (gp57/67) was immunopurified, and N-terminal amino acid sequencing identified it as human membrane cofactor protein (CD46), a member of the regulators of complement activation gene cluster...
  34. Maga T, Nishimura C, Weaver A, Frees K, Smith R. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. Hum Mutat. 2010;31:E1445-60 pubmed publisher
    ..genes including complement factor H (CFH), complement factor H-related 5 (CFHR5), complement factor I (CFI), CD46 (MCP), complement factor B (CFB), complement component 3 (C3) and thrombomodulin (THBD)...
  35. Mazur Bialy A, Pochec E. Riboflavin Reduces Pro-Inflammatory Activation of Adipocyte-Macrophage Co-culture. Potential Application of Vitamin B2 Enrichment for Attenuation of Insulin Resistance and Metabolic Syndrome Development. Molecules. 2016;21: pubmed
    ..necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), interleukin 1beta (IL-1β), monocyte chemotactic protein 1 (MCP-1), high-mobility group box 1 (HMGB1), transforming growth factor-beta 1 (TGFβ), interleukin 10 (IL-10), inducible ..
  36. Jimenez M, Hioe S, Kachooei A, Shearin J, Jones C, Rivlin M. Single-Bundle vs Double-Bundle (Anatomical) Reconstruction of the Thumb Ulnar Collateral Ligament: Biomechanical Study. Hand (N Y). 2017;:1558944717744338 pubmed publisher
    The goal of this study is to compare the biomechanical properties of anatomic (double-bundle) versus single-bundle reconstruction of the thumb metacarpophalangeal (MCP) joint ulnar collateral ligament (UCL) in a cadaveric model.
  37. Feng B, Chen S, Gordon A, Chakrabarti S. miR-146a mediates inflammatory changes and fibrosis in the heart in diabetes. J Mol Cell Cardiol. 2017;105:70-76 pubmed publisher
    ..with diabetes, increased expression of inflammatory markers and extracellular matrix proteins (IL6, TNF?, IL-1?, MCP-1, NF-?B, Col1?1, Col4?1) were seen compared to wild type controls...
  38. Wang Y, Zhang L, Zhao X, Yang W, Zhang R. An experimental study of the protective effect of simvastatin on sepsis-induced myocardial depression in rats. Biomed Pharmacother. 2017;94:705-711 pubmed publisher
    ..Levels of TNF-?, IL-1?, IL-6, MCP-1 and NO in myocardial tissues, together with levels of CTnI in serum were significantly declined in simvastatin-..
  39. Kaphalia L, Kalita M, Kaphalia B, Calhoun W. Effects of acute ethanol exposure on cytokine production by primary airway smooth muscle cells. Toxicol Appl Pharmacol. 2016;292:85-93 pubmed publisher
    ..In general, EtOH decreased secretion of IP-10, IL-6, eotaxin, GCSF, and MCP-1...
  40. Yao P, Zhao H, Mo W, He P. Laminar Shear Stress Promotes Vascular Endothelial Cell Autophagy Through Upregulation with Rab4. DNA Cell Biol. 2016;35:118-23 pubmed publisher
    ..In addition, the MCP level and the adhesion of monocytes were also obviously increased by Rab4 siRNA...
  41. Bi F, Meng X, Ma C, Yi G. Identification of miRNAs involved in fruit ripening in Cavendish bananas by deep sequencing. BMC Genomics. 2015;16:776 pubmed publisher
    ..Here, we investigated the miRNA populations from banana fruits in response to ethylene or 1-MCP treatment using a deep sequencing approach and bioinformatics analysis combined with quantitative RT-PCR validation...
  42. Abdel Latif M. Diethylcarbamazine citrate ameliorates insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. Int Immunopharmacol. 2015;29:607-612 pubmed publisher
    ..glucose tolerance, insulin resistance, blood triglycerides and levels of adipokines (leptin, TNF-α, IL-6 and MCP-1) were tested. The activity of cyclooxygenase (COX) in the liver tissue homogenate was also tested...
  43. Han H, Qiu F, Zhao H, Tang H, Li X, Shi D. Dietary Flaxseed Oil Prevents Western-Type Diet-Induced Nonalcoholic Fatty Liver Disease in Apolipoprotein-E Knockout Mice. Oxid Med Cell Longev. 2017;2017:3256241 pubmed publisher
    ..levels of genes involved in de novo fat synthesis (SREBP-1c, ACC), triacylglycerol catabolism (PPAR?, CPT1A, and ACOX1), inflammation (NF-?B, IL-6, TNF-?, and MCP-1), and oxidative stress (ROS, MDA, GSH, and SOD).
  44. Costa Reis P, Russo P, Zhang Z, Colonna L, Maurer K, Gallucci S, et al. The Role of MicroRNAs and Human Epidermal Growth Factor Receptor 2 in Proliferative Lupus Nephritis. Arthritis Rheumatol. 2015;67:2415-26 pubmed publisher
    ..Urinary levels of HER-2, monocyte chemotactic protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) were measured by enzyme-linked immunosorbent assay...
  45. Dihingia A, Ozah D, Baruah P, Kalita J, Manna P. Prophylactic role of vitamin K supplementation on vascular inflammation in type 2 diabetes by regulating the NF-?B/Nrf2 pathway via activating Gla proteins. Food Funct. 2018;9:450-462 pubmed publisher
    ..The results showed that plasma VK1 levels were significantly lower and MCP-1, fasting glucose, HbA1c, and insulin resistance (HOMA-IR) were significantly higher in T2D patients compared to ..
  46. Rong Y, Huang H, Liu J, Wei L. Protective Effects of Geniposide on Hepatic Ischemia/Reperfusion Injury. Transplant Proc. 2017;49:1455-1460 pubmed publisher
    ..aspartate aminotransferase, LDH lactic acid dehydrogenase, PI3K, AKT, p-AKT, m-TOR, Bax, BCL-2, interleukin (IL)-6, MCP-1, and tumor necrosis factor (TNF)-α were examined...
  47. Van Beeck A, van Den Broek M, Michielsen M, Didden K, Vuylsteke K, Verstreken F. Efficacy and safety of collagenase treatment for Dupuytren's disease: 2-year follow-up results. Hand Surg Rehabil. 2017;36:346-349 pubmed publisher
    ..Inclusion criteria were a contracture of at least 20° at the metacarpophalangeal (MCP) or the proximal interphalangeal (PIP) joint...
  48. Hazman O, Bozkurt M, Fidan A, Uysal F, Celik S. The Effect of Boric Acid and Borax on Oxidative Stress, Inflammation, ER Stress and Apoptosis in Cisplatin Toxication and Nephrotoxicity Developing as a Result of Toxication. Inflammation. 2018;41:1032-1048 pubmed publisher
    ..end of the study, oxidative stress-related (GSH, MDA, PCO, GPx, 8-OHdG), inflammation-related (TNF-?, IL-1?, IL-18, MCP-1, ICAM, TGF-?), apoptosis-related (p53, caspase 1, 3, 8, 12, bcl-2, bcl-xL, NFkB), and ER stress-related (GRP78, ..
  49. Rakhila H, Al Akoum M, Bergeron M, Leboeuf M, Lemyre M, Akoum A, et al. Promotion of angiogenesis and proliferation cytokines patterns in peritoneal fluid from women with endometriosis. J Reprod Immunol. 2016;116:1-6 pubmed publisher
    ..in endometriotic women most notably a marked increase in EGF, FGF-2, IL-1?, MIP-1?, TGF?, PDGF-AA, PDGF-BB, MCP-3, sCD40L, Gro Pan, IL-17?, MDC and Rantes...
  50. Partecke L, Speerforck S, Käding A, Seubert F, Kühn S, Lorenz E, et al. Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta-adrenergic receptor blockade. Pancreatology. 2016;16:423-33 pubmed publisher
    ..of splenocytes was significantly reduced regarding Th1- and Th2-cytokines including IFN-gamma, IL-6, IL-10 and MCP-1 (0.0011 < p < 0.043)...
  51. Andreassen S, Berg L, Nielsen S, Kristensen A, Jacobsen S. mRNA expression of genes involved in inflammation and haemostasis in equine fibroblast-like synoviocytes following exposure to lipopolysaccharide, fibrinogen and thrombin. BMC Vet Res. 2015;11:141 pubmed publisher
    ..mRNA expression of serum amyloid A (SAA), interleukin-6 (IL-6), monocyte chemotactic protein 1 (MCP-1), tissue factor (TF), plasminogen activator inhibitor 1 (PAI-1), urokinase plasminogen activator (uPA), vascular ..
  52. Sindhu S, Thomas R, Shihab P, Sriraman D, Behbehani K, Ahmad R. Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation. PLoS ONE. 2015;10:e0133494 pubmed publisher
    ..were collected from 33 obese, 22 overweight, and 10 lean individuals and the expression of IL-6R, IL-6, TNF-α, MCP-1, IP-10, CD11b, CD163, and CD68 was detected by immunohistochemistry; results were also confirmed by real-time RT-..
  53. Chen Y, Hu X, Zhou Y, Yu Z, Fu L, Zhang G, et al. Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity. J Immunol. 2016;197:4762-4770 pubmed
    ..LPS-induced upregulation of placental proinflammatory genes including Tnf-?, Il-1?, IL-6, Il-12, Mip-2, Kc, and Mcp-1 By contrast, OCA elevated anti-inflammatory cytokine IL-10 in maternal serum, amniotic fluid, and placenta...
  54. Srnec J, Wagner E, Rizzo M. Implant Arthroplasty for Proximal Interphalangeal, Metacarpophalangeal, and Trapeziometacarpal Joint Degeneration. J Hand Surg Am. 2017;42:817-825 pubmed publisher
    ..Although implant arthroplasty of the proximal interphalangeal (PIP), metacarpophalangeal (MCP), and trapeziometacarpal (TMC) joints predictably produce pain relief and high satisfaction, it has historically ..
  55. Li C, Li L, Yang C, Zhong Y, Wu D, Shi L, et al. Hepatoprotective effects of Methyl ferulic acid on alcohol-induced liver oxidative injury in mice by inhibiting the NOX4/ROS-MAPK pathway. Biochem Biophys Res Commun. 2017;493:277-285 pubmed publisher
    ..the expression of inflammatory factors tumour necrosis factor (TNF)-?, monocyte chemoattractant protein 1 (MCP-1), interleukin (IL)-1? and IL-6. MFA attenuated both mRNA and protein expression of NOX4,p22phox,CYP2E1,Bax/Bcl-2...
  56. Chu Y, Wang Y, Zheng Z, Lin Y, He R, Liu J, et al. Proinflammatory Effect of High Glucose Concentrations on HMrSV5 Cells via the Autocrine Effect of HMGB1. Front Physiol. 2017;8:762 pubmed publisher
    ..inflammatory processes by producing various cytokines and chemokines, such as monocyte chemoattractant protein 1 (MCP-1) and interleukin 8 (IL-8)...
  57. Kuatsjah E, Chan A, Kobylarz M, Murphy M, Eltis L. The bacterial meta-cleavage hydrolase LigY belongs to the amidohydrolase superfamily, not to the α/β-hydrolase superfamily. J Biol Chem. 2017;292:18290-18302 pubmed publisher
    ..In this pathway, LigY is proposed to catalyze the hydrolysis of the meta-cleavage product (MCP) 4,11-dicarboxy-8-hydroxy-9-methoxy-2-hydroxy-6-oxo-6-phenyl-hexa-2,4-dienoate...
  58. Wang Z, Hill J, Yunis E, Xiao L, Anderson D. Maternal CD46H*2 and IL1B-511*1 homozygosity in T helper 1-type immunity to trophoblast antigens in recurrent pregnancy loss. Hum Reprod. 2006;21:818-22 pubmed
    ..Since CD46 gene products also regulate maternal immune responses including Th1 immunity, we investigated whether CD46 gene ..
  59. Li Y, Fan X, Li C, Zhi X, Peng L, Han H, et al. The relationships among hyperuricemia, body mass index and impaired renal function in type 2 diabetic patients. Endocr J. 2017;: pubmed publisher
    ..UA also increased monocyte chemotactic protein-1 (MCP-1) expression and nuclear factor kappa B (NF-?B) activation...
  60. Tang K, Wu J, Xiong Z, Ji Y, Sun T, Guo X. Human acellular amniotic membrane: A potential osteoinductive biomaterial for bone regeneration. J Biomater Appl. 2017;:885328217739753 pubmed publisher
    ..The gene expression of CXCR-4, MCP-1, OC and CatK which were connected with cells recruitment and bone remodeling, was enhanced in the defects ..
  61. Kiang J, Smith J, Anderson M, Elliott T, Gupta P, Balakathiresan N, et al. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS ONE. 2017;12:e0184393 pubmed publisher
    ..an increase of IL-1, IL-2, IL-3, IL-5, IL-6, IL-12, IL-13, IL-15, IL-17A, IL-18, G-CSF, CM-CSF, eotaxin, IFN-?, MCP-1, MIP, RANTES, and TNF-?, which were all increased by hemorrhage alone, except IL-9, IL-17A, and MCP-1...
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    ..Cytokine (IFN-?, TNF, IL-2, IL-4, IL-6, IL-10, and IL-17A) and chemokine (CXCL8/IL-8, CCL5/RANTES, CXCL9/MIG, CCL2/MCP-1, and CXCL10/IP-10) levels were quantified in serum and in PBMC culture supernatants by CBA or ELISA...
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    ..The expression of several factors including chemotactic factor MCP-1, proinflammatory cytokines including TNF-α and IL-6, as well as the kidney injury markers, as Kim-1 and ..
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    ..This study aimed to compare the serum levels of monocyte chemoattractant protein-1 (MCP-1), transforming growth factor-beta1 (TGF-beta1), nerve growth factor (NGF), resistin and hyaluronic acid (HA) in ..
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    ..activation as evidenced by the expression of contractile proteins, the production of the proinflammatory cytokines MCP-1 (monocyte chemotactic protein 1) and IL-6 (interleukin-6), the deposition of extracellular matrix, and cell ..
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    ..and chemokines, including interleukin-1? (IL-1?), tumor necrosis factor ? (TNF-?), monocyte chemotactic protein 1 (MCP-1), and type 1 interferons (IFN-? and IFN-?)...
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    ..Increased urinary excretion of MCP-1 and TGF-β was also observed. All these alterations were less intense in the losartan + calcitriol group...
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    ..of kidney injury molecule-1 (KIM-1), calbindin, interleukin-18 (IL-18), and monocyte chemoattractant protein-1 (MCP-1) in HIV associated normotensive and preeclamptic pregnancies...
  69. Fierz W. Age-Related Macular Degeneration: A Connection between Human Herpes Virus-6A-Induced CD46 Downregulation and Complement Activation?. Front Immunol. 2017;8:1314 pubmed publisher
    ..is seen in multiple sclerosis (MS) where human herpes virus-6A (HHV-6A) infects astrocytes by docking to the CD46 surface receptor...
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    ..a client satisfaction questionnaire at the University of California, Los Angeles Mobile Clinic Project (UCLA MCP)...
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    ..Two independent studies showed that transfection of nonsusceptible rodent cells with human CD46 renders these cells permissive to infection with the Edmonston and Halle vaccine strains of measles virus (Dorig et ..
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    ..of intraocular lens showed similar patterns of elevation of IL-1?, IL-4, IL-6, IL-8, IL-10, IL-13, IL-17A, MIP-1?, MCP-1, E-selectin, P-selectin and sICAM-1...