CD41

Summary

Gene Symbol: CD41
Description: integrin subunit alpha 2b
Alias: BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GTA, HPA3, PPP1R93, integrin alpha-IIb, GPalpha IIb, alphaIIb protein, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), platelet fibrinogen receptor, alpha subunit, platelet glycoprotein IIb of IIb/IIIa complex, platelet membrane glycoprotein IIb, platelet-specific antigen BAK, protein phosphatase 1, regulatory subunit 93
Species: human
Products:     CD41

Top Publications

  1. Naik U, Patel P, Parise L. Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J Biol Chem. 1997;272:4651-4 pubmed
    The mechanism by which platelets regulate the function of integrin alphaIIbbeta3 (or GPIIb/IIIa), the platelet fibrinogen receptor, is unknown but may involve the binding of proteins or other factors to integrin cytoplasmic domains...
  2. Wang R, Shattil S, Ambruso D, Newman P. Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex. J Clin Invest. 1997;100:2393-403 pubmed
  3. Li R, Mitra N, Gratkowski H, Vilaire G, Litvinov R, Nagasami C, et al. Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science. 2003;300:795-8 pubmed
    ..These results suggest that homomeric associations involving transmembrane domains provide a driving force for integrin activation. They also suggest a structural basis for the coincidence of integrin activation and clustering. ..
  4. Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis V, et al. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol. 2008;181:1211-22 pubmed publisher
    ..Thus, talin recruitment to alphaIIbbeta3 by RIAM mediates agonist-induced alphaIIbbeta3 activation, with implications for hemostasis and thrombosis. ..
  5. Leisner T, Yuan W, DeNofrio J, Liu J, Parise L. Tickling the tails: cytoplasmic domain proteins that regulate integrin alphaIIbbeta3 activation. Curr Opin Hematol. 2007;14:255-61 pubmed
    ..Discussion of recent developments in elucidating the mechanism of integrin activation, with particular focus on the platelet integrin alphaIIbbeta3, is provided in this review. ..
  6. Zhu J, Carman C, Kim M, Shimaoka M, Springer T, Luo B. Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling. Blood. 2007;110:2475-83 pubmed
    ..This defect was rescued by reduction of the disulfide bond. Our results demonstrate that the separation of transmembrane domains is required for integrin outside-in signal transduction. ..
  7. Kunicki T, Williams S, Nugent D, Harrison P, Segal H, Syed A, et al. Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease. Thromb Haemost. 2009;101:123-33 pubmed
    ..03) and plasma von Willebrand Factor antigen levels (p < 0.001), which likely contributes to resistance to the inhibitory effects of ASA in the PFA-100. ..
  8. Gong H, Shen B, Flevaris P, Chow C, Lam S, Voyno Yasenetskaya T, et al. G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling. Science. 2010;327:340-3 pubmed publisher
    ..We conclude that integrins are noncanonical Galpha13-coupled receptors that provide a mechanism for dynamic regulation of RhoA. ..
  9. Kunicki T, Williams S, Nugent D, Yeager M. Mean platelet volume and integrin alleles correlate with levels of integrins ?(IIb)?(3) and ?(2)?(1) in acute coronary syndrome patients and normal subjects. Arterioscler Thromb Vasc Biol. 2012;32:147-52 pubmed publisher
    ..Because of the hyperactivity of larger platelets, MPV is an accurate metric of risk for adverse outcome in ACS. ..

More Information

Publications113 found, 100 shown here

  1. Kahner B, Kato H, Banno A, Ginsberg M, Shattil S, Ye F. Kindlins, integrin activation and the regulation of talin recruitment to ?IIb?3. PLoS ONE. 2012;7:e34056 pubmed publisher
    ..Thus, kindlins do not promote initial talin recruitment to ?IIb?3, suggesting that they co-activate integrin through a mechanism independent of recruitment. ..
  2. Liu J, Jackson C, Gruppo R, Jennings L, Gartner T. The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling. Blood. 2005;105:4345-52 pubmed
  3. Ma Y, Yang J, Pesho M, Vinogradova O, Qin J, Plow E. Regulation of integrin alphaIIbbeta3 activation by distinct regions of its cytoplasmic tails. Biochemistry. 2006;45:6656-62 pubmed
    ..Together, these data provide molecular insights into how distinct regions of the cytoplasmic tails differentially and cooperatively regulate integrin activation. ..
  4. Knezevic I, Leisner T, Lam S. Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3. J Biol Chem. 1996;271:16416-21 pubmed
    ..Although talin has been suggested to act as a linkage protein mediating the attachment of GPIIb-IIIa to actin filaments, direct binding of GPIIb-IIIa to this cytoskeletal protein has not been demonstrated...
  5. Perera H, Ma Y, Yang J, HIRBAWI J, Plow E, Qin J. Membrane binding of the N-terminal ubiquitin-like domain of kindlin-2 is crucial for its regulation of integrin activation. Structure. 2011;19:1664-71 pubmed publisher
    ..These data suggest a membrane-binding function of the ubiquitin-like domain of kindlin-2, which is likely common for all kindlins to promote their localization to the plasma membrane and control integrin activation. ..
  6. Shattil S. Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol. 2005;15:399-403 pubmed
    ..Here, the biochemical basis for and biological significance of this integrin-SFK interaction is summarized, and I propose a general mechanism for initiation of outside-in integrin signaling. ..
  7. Lau T, Kim C, Ginsberg M, Ulmer T. The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J. 2009;28:1351-61 pubmed publisher
    ..The structurally unique, highly conserved integrin alphaIIbbeta3 TM complex rationalizes bi-directional signalling and represents the first structure of a heterodimeric TM receptor complex. ..
  8. Litvinov R, Barsegov V, Schissler A, Fisher A, Bennett J, Weisel J, et al. Dissociation of bimolecular ?IIb?3-fibrinogen complex under a constant tensile force. Biophys J. 2011;100:165-73 pubmed publisher
    ..Taken together, these data provide important quantitative and qualitative characteristics of ?IIb?3-fibrinogen binding and unbinding that underlie the dynamics of platelet adhesion and aggregation in blood flow. ..
  9. Law D, Nannizzi Alaimo L, Phillips D. Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation. J Biol Chem. 1996;271:10811-5 pubmed
    ..The data suggest that tyrosine phosphorylation of an integrin beta subunit may be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin. ..
  10. Derrick J, Shattil S, Poncz M, Gruppo R, Gartner T. Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an alphaIIbbeta3 interacting peptide. Thromb Haemost. 2001;86:894-901 pubmed
    ..Furthermore, these studies suggest that not all alphaIIbbeta3-dependent platelet responses require an intact beta3 cytoplasmic tail. ..
  11. Wonerow P, Obergfell A, Wilde J, Bobe R, Asazuma N, Brdicka T, et al. Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets. Biochem J. 2002;364:755-65 pubmed
  12. Kazemi A, Abolghasemi H, Kazemzadeh S, Vahidi R, Faranoush M, Farsinejad A, et al. Molecular characterization of Glanzmann's thrombasthenia in Iran: identification of three novel mutations. Blood Coagul Fibrinolysis. 2017;: pubmed publisher
    Quantitative and/or qualitative defects of the platelet membrane glycoprotein IIb/IIIa complex lead to the clinical entity of Glanzmann's thrombasthenia...
  13. Zahran A, Saad K, Elsayh K, Alblihed M, Embaby M. Identification of Clinicopathological Spectrum, Platelet Glycoprotein IIb/IIIa complex and Platelet Antibodies in Egyptian Children with Glanzmann's Thrombasthenia. Arch Immunol Ther Exp (Warsz). 2017;65:565-571 pubmed publisher
    ..Forty children with GT were assessed for the expression of GPIIb-IIIa on the platelet surface and platelet antibodies by using flow cytometry, to determine the most common GT ..
  14. Wen Y, Chen D. Human platelet antigens in disease. Clin Chim Acta. 2018;484:87-90 pubmed publisher
    ..Each HPA represent one of six platelet glycoproteins GPIIb, GPIIIa, GPIa, GPIbα, GPIbβ, and CD109, and six biallelic systems are grouped...
  15. Andres O, Henning K, Strauß G, Pflug A, Manukjan G, Schulze H. Diagnosis of platelet function disorders: A standardized, rational, and modular flow cytometric approach. Platelets. 2017;:1-10 pubmed publisher
    ..significant platelet disorders: Glanzmann thrombasthenia or Glanzmann-like diseases (fibrinogen receptor GPIIb-IIIa), Bernard-Soulier syndrome (von Willebrand-factor receptor complex GPIb-IX-V) and less well characterized ?1-..
  16. Hayashi T, Amakishi E, Inoue M, Hirayama F. Establishment of a cell line panel for the detection of antibodies against human platelet antigen 4b. Int J Hematol. 2011;93:170-175 pubmed publisher
    ..Glycoprotein IIIa (GPIIIa) cDNA encoding HPA-4b was individually co-transduced with that of wild-type GPIIb in K562 cells, which is a non-adherent cell line, using a retroviral vector...
  17. Wojtkowska I, Stepinska J, Stępień Wojno M, Sobota M, Kopaczewski J, Reszka Z, et al. Current patterns of antithrombotic and revascularisation therapy in patients hospitalised for acute coronary syndromes. Data from the Polish subset of the EPICOR study. Kardiol Pol. 2017;75:445-452 pubmed publisher
    ..combinations of antiplatelet drugs included ASA + clopidogrel (predominantly in NSTEMI/UA) or ASA + clopidogrel + GPIIb/IIIa inhibitor (predominantly in STEMI), while other possible combinations were not used...
  18. Hauschner H, Mor Cohen R, Messineo S, Mansour W, Seligsohn U, Savoia A, et al. Abnormal cytoplasmic extensions associated with active αIIbβ3 are probably the cause for macrothrombocytopenia in Glanzmann thrombasthenia-like syndrome. Blood Coagul Fibrinolysis. 2015;26:302-8 pubmed publisher
    ..These results suggest that the active conformation of αIIbβ3 can induce cytoskeletal rearrangements that lead to impaired proplatelet formation. ..
  19. Bury L, Falcinelli E, Chiasserini D, Springer T, Italiano J, Gresele P. Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia. Haematologica. 2016;101:46-56 pubmed publisher
  20. Dupuis A, Gachet C. Inherited platelet disorders : Management of the bleeding risk. Transfus Clin Biol. 2018;25:228-235 pubmed publisher
    ..severe thrombocytopenia (<40,000 platelets/?L) and signalling protein abnormalities affecting the activation of GPIIb-IIIa, a membrane glycoprotein essential for platelet aggregation...
  21. Nurden A. Acquired Glanzmann thrombasthenia: From antibodies to anti-platelet drugs. Blood Rev. 2019;: pubmed publisher
    ..This review looks at these conditions, emphasizing molecular mechanisms, therapy, patient management and future directions for research. ..
  22. Nurden A. Should studies on Glanzmann thrombasthenia not be telling us more about cardiovascular disease and other major illnesses?. Blood Rev. 2017;31:287-299 pubmed publisher
    ..This survey shows an urgent need for a concerted international effort to better determine how loss of αIIbβ3 and αvβ3 influences health and disease. ..
  23. Zhang J, Feng F, Wang Q, Zhu X, Fu H, Xu L, et al. Platelet-Derived Growth Factor-BB Protects Mesenchymal Stem Cells (MSCs) Derived From Immune Thrombocytopenia Patients Against Apoptosis and Senescence and Maintains MSC-Mediated Immunosuppression. Stem Cells Transl Med. 2016;5:1631-1643 pubmed
    ..Their impaired ability for inhibiting activated T cells, inducing Tregs, and suppressing the synthesis of anti-GPIIb-IIIa antibodies was restored after PDGF-BB treatment...
  24. Ogawa Y, Kunishima S, Yanagisawa K, Osaki Y, Uchiyama Y, Matsumoto N, et al. Successful management of perioperative hemostasis in a patient with Glanzmann thrombasthenia who underwent a right total mastectomy. Int J Hematol. 2017;105:221-225 pubmed publisher
    ..However, GT patients often possess alloantibodies against GPIIb/IIIa and/or HLA, which cause resistance to platelet transfusion...
  25. Basani R, Vilaire G, Shattil S, Kolodziej M, Bennett J, Poncz M. Glanzmann thrombasthenia due to a two amino acid deletion in the fourth calcium-binding domain of alpha IIb: demonstration of the importance of calcium-binding domains in the conformation of alpha IIb beta 3. Blood. 1996;88:167-73 pubmed
    The integrin alpha IIb beta 3, a calcium-dependent heterodimer, plays a critical role in platelet aggregation...
  26. Ortlepp J, Lauscher J, Janssens U, Minkenberg R, Hanrath P, Hoffmann R. Analysis of several hundred genetic polymorphisms may improve assessment of the individual genetic burden for coronary artery disease. Eur J Intern Med. 2002;13:485-492 pubmed
    ..An analysis of multiple polymorphisms, some several hundred, each with a small impact, may allow improved assessment of the individual genetic burden for CAD. Larger studies are needed to prove this hypothesis. ..
  27. Lekakis J, Bisti S, Tsougos E, Papathanassiou A, Dagres N, Ikonomidis I, et al. Platelet glycoprotein IIb HPA-3 polymorphism and acute coronary syndromes. Int J Cardiol. 2008;127:46-50 pubmed
    There is considerable research interest about the platelet GPIIb/IIIa receptor polymorphisms in CAD...
  28. Jimenez S, Tassies D, Espinosa G, Garcia Criado A, Plaza J, Monteagudo J, et al. Double heterozygosity polymorphisms for platelet glycoproteins Ia/IIa and IIb/IIIa increases arterial thrombosis and arteriosclerosis in patients with the antiphospholipid syndrome or with systemic lupus erythematosus. Ann Rheum Dis. 2008;67:835-40 pubmed
    ..The coexistence of both 807 T and PlA2 alleles increased the arterial thrombosis risk in patients with APS and preclinical arteriosclerosis in patients with SLE. ..
  29. Hato T, Yamanouchi J, Tamura T, Yakushijin Y, Sakai I, Yasukawa M. Cooperative role of the membrane-proximal and -distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIb beta3 activation. J Biol Chem. 2008;283:5662-8 pubmed publisher
    ..These results suggest that the beta3 membrane-proximal and -distal residues cooperatively regulate talin-mediated alpha IIb beta3 activation. ..
  30. Miyakawa K, Joshi N, Sullivan B, Albee R, Brandenberger C, Jaeschke H, et al. Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice. Blood. 2015;126:1835-43 pubmed publisher
    ..Platelet depletion with an anti-CD41 antibody also significantly reduced APAP-mediated liver injury and thrombin generation, indicated by the ..
  31. Meiklejohn D, Vickers M, Morrison E, Dijkhuisen R, Moore I, Urbaniak S, et al. In vivo platelet activation in atherothrombotic stroke is not determined by polymorphisms of human platelet glycoprotein IIIa or Ib. Br J Haematol. 2001;112:621-31 pubmed
    ..These data suggest an underlying prothrombotic state, but do not support the polymorphisms studied as risk factors for thrombotic stroke in this population. ..
  32. Parikka M, Nissinen L, Kainulainen T, Bruckner Tuderman L, Salo T, Heino J, et al. Collagen XVII promotes integrin-mediated squamous cell carcinoma transmigration--a novel role for alphaIIb integrin and tirofiban. Exp Cell Res. 2006;312:1431-8 pubmed
    ..Together, these data demonstrate a novel interaction between collagen XVII and alphaIIb integrin and also suggest a possibility to use tirofiban to inhibit the invasion and progression of alphaIIb expressing SCC tumors. ..
  33. Kannan M, Yadav B, Ahmad F, Saxena R. Role of RFLP using TspRI for carrier detection in Glanzmann's thrombasthenia: a report on two families. Int J Lab Hematol. 2010;32:e158-62 pubmed publisher
    ..Flow cytometry analysis for GPIIb/IIIa expression was done using CD61 and CD41 markers in these patients and their family members including siblings...
  34. Blue R, Li J, Steinberger J, Murcia M, Filizola M, Coller B. Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3. J Biol Chem. 2010;285:17604-13 pubmed publisher
    ..Our data are consistent with alphaIIb extension resulting in increased access to the ligand-binding site and/or facilitating the conformational change(s) in beta3 that affect the intrinsic affinity of the binding pocket for ligand. ..
  35. Tang W, Zhang C, Lu F, Tang J, Lu Y, Cui X, et al. Spectrum of α-thalassemia and β-thalassemia mutations in the Guilin Region of southern China. Clin Biochem. 2015;48:1068-72 pubmed publisher
    ..The β-thal anomalies were related to 14 gene mutations and 30 genotypes, with the seven most common mutations [CD41-42 (-TTCT) (52.02%), CD17 (A>T) (22.12%), IVS-II-654 (C>T) (11.29%), -28 (A>G) (5.01%), CD71-72 (4...
  36. Verma S, Modi A, Singh A, Teotia R, Kadam S, Bellare J. Functionally coated polyethersulfone hollow fiber membranes: A substrate for enhanced HepG2/C3A functions. Colloids Surf B Biointerfaces. 2018;164:358-369 pubmed publisher
    ..In the present study, novel glutaraldehyde (GTA)-crosslinked gelatin (gel)-coated polyethersulfone (X-gel-PT) HFMs were manufactured using triple orifice spinneret ..
  37. O Connor F, Shields D, Fitzgerald A, Cannon C, Braunwald E, Fitzgerald D. Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes. Blood. 2001;98:3256-60 pubmed
    ..the influence of the Pl(A) polymorphism of glycoprotein IIIa (GPIIIa) in determining the response to an oral GPIIb/IIIa antagonist, orbofiban, in patients with unstable coronary syndromes...
  38. Mor Cohen R, Rosenberg N, Peretz H, Landau M, Coller B, Awidi A, et al. Disulfide bond disruption by a beta 3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active alpha IIb beta 3. Thromb Haemost. 2007;98:1257-65 pubmed
    ..In conclusion, the novel ancestral mutation found in a cluster of Jordanian GT patients disrupts a conserved Cys549-Cys558 bond which results in reduced production of constitutively active alpha IIb beta 3. ..
  39. Shen W, Ding Q, Jin P, Wang X, Jiang Y, Li S, et al. A novel Pro126His beta propeller mutation in integrin alphaIIb causes Glanzmann thrombasthenia by impairing progression of pro-alphaIIbbeta3 from endoplasmic reticulum to Golgi. Blood Cells Mol Dis. 2009;42:44-50 pubmed publisher
    ..The impaired alphaIIbbeta3 transport is responsible for the thrombasthenia in this patient. ..
  40. Chen Z, Mondal N, Ding J, Koenig S, Slaughter M, Griffith B, et al. Activation and shedding of platelet glycoprotein IIb/IIIa under non-physiological shear stress. Mol Cell Biochem. 2015;409:93-101 pubmed publisher
    ..05, 0.5, 1.5 s), created by a specific blood shearing system. The activation and shedding of the platelet GPIIb/IIIa were analyzed using flow cytometry and enzyme-linked immunosorbent assay...
  41. Undi R, Sarvothaman S, Narasaiah K, Gutti U, Gutti R. Toll-like receptor 2 signalling: Significance in megakaryocyte development through wnt signalling cross-talk and cytokine induction. Cytokine. 2016;83:245-249 pubmed publisher
    ..causes increase in the cytokine production, particularly IL-6, which has been shown to stimulate CFU formation and CD41 expression...
  42. Ferreira A, Perelshtein I, Perkas N, Gedanken A, Cunha J, Cavaco Paulo A. Detection of human neutrophil elastase (HNE) on wound dressings as marker of inflammation. Appl Microbiol Biotechnol. 2017;101:1443-1454 pubmed publisher
    ..two immobilization methods were tested: sonochemistry immobilization onto a cotton bandage and glutaraldehyde (GTA)-assisted chemical crosslinking onto a polyamide dressing...
  43. Gao J, Zoller K, Ginsberg M, Brugge J, Shattil S. Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. EMBO J. 1997;16:6414-25 pubmed
    ..Furthermore, there are fundamental differences in the activation of Syk by alpha IIb beta 3 and immune response receptors, suggesting a unique role for integrins in Syk function. ..
  44. Bennett J, Palmer L, Musk A, Erber W. Gene frequencies of human platelet antigens 1-5 in indigenous Australians in Western Australia. Transfus Med. 2002;12:199-203 pubmed
  45. Litjens P, Gorter G, Ylanne J, Akkerman J, van Willigen G. Involvement of the beta3 E749ATSTFTN756 region in stabilizing integrin alphaIIbbeta3-ligand interaction. J Thromb Haemost. 2003;1:2216-24 pubmed
    ..We conclude that the E749ATSTFTN756 region of the beta3-tail stabilizes the binding of soluble and surface-bound ligand to integrin alphaIIbbeta3 via a mechanism that involves the phosphorylation of FAK. ..
  46. Aylward K, Meade G, Ahrens I, Devocelle M, Moran N. A novel functional role for the highly conserved alpha-subunit KVGFFKR motif distinct from integrin alphaIIbbeta3 activation processes. J Thromb Haemost. 2006;4:1804-12 pubmed
    ..In addition to regulating integrin alphaIIbbeta3 activation state, the KVGFFKR motif also influences cytoskeletal reorganization. This activity is critically determined by F992 and F993 within the seven amino acid sequence. ..
  47. Al Subaie A, Al Absi I, Al Ola K, Saidi S, Fawaz N, Almawi W. Gene frequencies of human platelet alloantigens in Bahraini Arabs. Am J Hematol. 2007;82:242-4 pubmed
    ..Our results provide basic information for further studies of the HPA system polymorphism, which in turn will be instrumental in understanding and treating immune-mediated platelet disorders. ..
  48. Furusawa A, Sadashivaiah K, Singh Z, Civin C, Banerjee A. Inefficient megakaryopoiesis in mouse hematopoietic stem-progenitor cells lacking T-bet. Exp Hematol. 2016;44:194-206.e17 pubmed publisher
    ..Differences observed with respect to megakaryocyte number and maturity, as assessed by level of expression of CD41 and CD61, and megakaryocyte ploidy, in T-bet-deficient HSPCs were not associated with altered proliferation or ..
  49. Enjeti A, Ariyarajah A, D Crus A, Seldon M, Lincz L. Circulating microvesicle number, function and small RNA content vary with age, gender, smoking status, lipid and hormone profiles. Thromb Res. 2017;156:65-72 pubmed publisher
    ..143 volunteer blood donors (males=80, females=63) was evaluated by standardized flow cytometry for MV expressing CD41 (platelet-derived), CD105 (endothelial-derived), CD235 (red cell-derived), TF (tissue factor) and ..
  50. McDowall A, Inwald D, Leitinger B, Jones A, Liesner R, Klein N, et al. A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins. J Clin Invest. 2003;111:51-60 pubmed
  51. Shim C, Liu Y, Atkinson T, Xie A, Foster T, Davidson B, et al. Molecular Imaging of Platelet-Endothelial Interactions and Endothelial von Willebrand Factor in Early and Mid-Stage Atherosclerosis. Circ Cardiovasc Imaging. 2015;8:e002765 pubmed publisher
    ..signal commensurate with the decrease in platelet count after immunodepletion with anti-GPIb or anti-CD41 antibody...
  52. Oliveira C, Peres D, Graziola F, Chacra N, Araújo G, Flórido A, et al. Cutaneous biocompatible rutin-loaded gelatin-based nanoparticles increase the SPF of the association of UVA and UVB filters. Eur J Pharm Sci. 2016;81:1-9 pubmed publisher
    ..The safety profile indicated that GNPs and glutaraldehyde (GTA) decreased HaCaT cell viability in a concentration/time-dependent manner...
  53. Gomes I, Malheiro J, Mergulhão F, Maillard J, Simões M. Comparison of the efficacy of natural-based and synthetic biocides to disinfect silicone and stainless steel surfaces. Pathog Dis. 2016;74:ftw014 pubmed publisher
    ..Minimum inhibitory concentration was determined for synthetic (benzalkonium chloride-BAC, glutaraldehyde-GTA,ortho-phthalaldehyde-OPA and peracetic acid-PAA) and natural-based (cuminaldehyde-CUM), eugenol-EUG and indole-3-..
  54. Hu L, Shang X, Yi S, Cai R, Li Z, Liu C, et al. Two novel copy number variations involving the ?-globin gene cluster on chromosome 16 cause thalassemia in two Chinese families. Mol Genet Genomics. 2016;291:1443-50 pubmed publisher
    ..Proband A is a coinheritance of ?(CD41-42) and ????(282) and showed severe ?-thalassemia intermedia phenotype...
  55. Bingül I, Vural P, Dogru Abbasoglu S, Cil E, Uysal M. Vascular endothelial growth factor G+405C polymorphism may contribute to the risk of developing papillary thyroid carcinoma. J Clin Lab Anal. 2017;31: pubmed publisher
    ..422, r2 =.035), and +405/-2578 (D'=.43, r2 =.038) locuses. Additionally, the +405/-460/-2578 GTA haplotype was found to be protective, whereas CTA haplotype to be related with increased PTC risk...
  56. Liu L, Yan X, Liu J, Xia M, Lu C, Emmorey K, et al. Graph theoretical analysis of functional network for comprehension of sign language. Brain Res. 2017;1671:55-66 pubmed publisher
    ..Using graph theoretical analysis (GTA) and fMRI, we compared the large-scale functional network organization in hearing signers with non-signers during ..
  57. Pallaud C, Sass C, Zannad F, Siest G, Visvikis S. [APOC3, CETP, beta-fibrinogen and MTHFR are genetic determinants of carotid intim-media thickness (Stanislas cohort)]. Arch Mal Coeur Vaiss. 2001;94:851-4 pubmed
    ..05). The most interesting finding was that altogether these genes in men were able to explain a considerable part, 20.6%, of CIMT variability. Therefore, our study gives a new opportunity to understand CIMT variability. ..
  58. Wong P, Watson C, Crain E. The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys. J Thromb Thrombolysis. 2016;41:514-21 pubmed publisher
    ..Abciximab, a GPIIb-IIIa antagonist, and cangrelor, a P2Y12 antagonist, were utilized to validate these monkey models...
  59. Weng J, Kao T, Huang G, Tyan Y, Tseng H, Ho M. Evaluation of structural connectivity changes in betel-quid chewers using generalized q-sampling MRI. Psychopharmacology (Berl). 2017;234:1945-1955 pubmed publisher
    ..Graph theoretical analysis (GTA) and network-based statistical (NBS) analysis were also performed to identify the structural network differences ..
  60. Lang A, Westbye A, Beatty J. The Distribution, Evolution, and Roles of Gene Transfer Agents in Prokaryotic Genetic Exchange. Annu Rev Virol. 2017;4:87-104 pubmed publisher
    ..b>GTA production can be regulated by the producing organism and coordinated to coincide with development of the ..
  61. Dimitriou A, Stathopoulos P, Mitsios J, Sakarellos Daitsiotis M, Goudevenos J, Tsikaris V, et al. Inhibition of platelet activation by peptide analogs of the beta(3)-intracellular domain of platelet integrin alpha(IIb)beta(3) conjugated to the cell-penetrating peptide Tat(48-60). Platelets. 2009;20:539-47 pubmed publisher
    ..Further studies are necessary to support whether such conjugated peptides may be useful tools for the development of potent antiplatelet agents acting intracellularly through the platelet integrin alpha(IIb)beta(3). ..
  62. Frelinger A, Grace R, Gerrits A, Berny Lang M, Brown T, Carmichael S, et al. Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP. Blood. 2015;126:873-9 pubmed publisher
    ..through the protease activated receptor 1 (PAR1) thrombin receptor (TRAP-stimulated P-selectin, activated GPIIb-IIIa, and CD42b), independent of platelet count, are associated with concurrent bleeding severity in ITP...
  63. Sun C, Chen P, Lu W, Liu J. Tyr178 of beta3 is critical for alphaIIb maturation and macromolecular ligand binding to alphaIIbbeta3. Thromb Res. 2008;122:203-10 pubmed publisher
    ..We also propose that a residue with appropriate side-chain size and hydrophobicity at position 178 is spatially required for formation of the correct tertiary structure of the site. ..
  64. de La Vega Elena C, Nogues N, Fernandez Montoya A, Chialina S, Blanzaco P, Theiller E, et al. Human platelet-specific antigens frequencies in the Argentinean population. Transfus Med. 2008;18:83-90 pubmed publisher
    ..It allowed us to establish a panel of characterized blood donors necessary for the serological work out and as a source for compatible platelets transfusion. ..
  65. Yuan X, Chen F, Xia K, Fu G, Jian Z, Jie Q, et al. Effect of alphaIIb Ala477Pro(A446P) mutation of the platelet glycoprotein on the expression of alphaIIbbeta3 complex. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34:712-7 pubmed
    ..alphaIIbA477P (A446P) mutation distinctly reduces the expression of alphaIIbbeta3 complex on the membrane. This mutation may interfere the formation of alphaIIbbeta3 complex or impair the proper conformation of alphaIIb subunit. ..
  66. Liu Z, Gao M, Han Q, Lou S, Fang J. Platelet glycoprotein IIb/IIIa (HPA-1 and HPA-3) polymorphisms in patients with hemorrhagic fever with renal syndrome. Hum Immunol. 2009;70:452-6 pubmed publisher
    ..These results indicate that HPA-3 polymorphism may be one of the inherited risk factors associated with the susceptibility of hantavirus infection and the disease severity of HFRS. ..
  67. Abboud N, Ghazouani L, Ben Hadj Khalifa S, Anabi F, Added F, Khalfallah A, et al. Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease. J Thromb Thrombolysis. 2010;29:409-15 pubmed publisher
    The contribution of human platelet antigen (HPA)-1 (GPIIb/IIIa), HPA-2 (GPIb/IX), and HPA-3 (GPIIb/IIIa) polymorphisms to the risk of coronary artery disease (CAD) was investigated in 341 CAD patients and 316 matched control subjects...
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    ..These data provide a mechanism for enhancement of platelet activity by alpha(IIb)beta(3) inhibitors, but also reveal a potentially important signaling pathway operating from the integrin to GPVI signaling. ..
  69. Liu T, Zhang Z, Yu C, Zeng C, Xu X, Wu G, et al. Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation. Br J Pharmacol. 2017;174:4308-4328 pubmed publisher
    ..The effects of tetrandrine on the expression of CD41 and cell morphology were investigated in AMKL cells...
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    ..Expression of rat endothelial cell antigen, CD34, CD41, P-selectin, and caspase-3 in the liver were analyzed...
  71. Dardik R, Shenkman B, Tamarin I, Eskaraev R, Harsfalvi J, Varon D, et al. Factor XIII mediates adhesion of platelets to endothelial cells through alpha(v)beta(3) and glycoprotein IIb/IIIa integrins. Thromb Res. 2002;105:317-23 pubmed
    ..Normal washed platelets also bound surface-immobilized or soluble FXIII and FXIIIa, and the binding was GPIIb/IIIa dependent...
  72. Filizola M, Hassan S, Artoni A, Coller B, Weinstein H. Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3. J Biol Chem. 2004;279:24624-30 pubmed
    ..In addition, it suggests mechanistic hypotheses pertaining to both naturally occurring mutations responsible for Glanzmann thrombasthenia and to point mutations that affect ligand binding. ..
  73. Odachi R, Tamaki T, Ito M, Okita T, Kitamura Y, Sobue T. Nurses' Experiences of End-of-life Care in Long-term Care Hospitals in Japan: Balancing Improving the Quality of Life and Sustaining the Lives of Patients Dying at Hospitals. Asian Nurs Res (Korean Soc Nurs Sci). 2017;11:207-215 pubmed publisher
    ..such older patients at the end-of-life stage in long-termcare wards via the modified grounded theory approach (M-GTA)...
  74. Uzan G, Frachet P, Lajmanovich A, Prandini M, Denarier E, Duperray A, et al. cDNA clones for human platelet GPIIb corresponding to mRNA from megakaryocytes and HEL cells. Evidence for an extensive homology to other Arg-Gly-Asp adhesion receptors. Eur J Biochem. 1988;171:87-93 pubmed
    Platelet glycoprotein (GP) IIb is one of the two subunits of the common platelet adhesion receptor, GPIIb-IIIa. The isolation, characterization and sequencing of cDNA clones encoding for the two polypeptide chains of GPIIb are described...
  75. Sun D, Lo S, Tsai W, Lin C, Yu M, Chen Y, et al. PI3-kinase is essential for ADP-stimulated integrin alpha(IIb)beta3-mediated platelet calcium oscillation, implications for P2Y receptor pathways in integrin alpha(IIb)beta3-initiated signaling cross-talks. J Biomed Sci. 2005;12:937-48 pubmed
    ..Our data indicates the important roles of PI3K and granular released ADP in coordinating the feedback regulations in integrin alpha(IIb)beta3-mediated platelet activation. ..
  76. Gorgi Y, Sfar I, Ben Abdallah T, Aouadi H, Abderrahim E, Bardi R, et al. Human platelet antigens: HPA-1, -2, -3, -4, and -5 polymorphisms in kidney transplantation. Transplant Proc. 2007;39:2568-70 pubmed
    ..4%, respectively), but the difference was not significant. The genotype distribution of HPA-1, -3, and -4 genes of GPIIb/IIIa revealed that the most frequent genotype was HPA-1a1a/3a3a/4a4a (19%) among controls and HPA-1a1a/3a3a/4a4b (..
  77. Kannan M, Ahmad F, Yadav B, Kumar R, Choudhry V, Saxena R. Molecular defects in ITGA2B and ITGB3 genes in patients with Glanzmann thrombasthenia. J Thromb Haemost. 2009;7:1878-85 pubmed publisher
    ..Missense mutations were identified as the defects responsible for most GT patients. Carrier detection and genetic counseling in these families is a potentially effective alternative for decreasing the burden of severe type of GT. ..
  78. Provasi D, Negri A, Coller B, Filizola M. Talin-driven inside-out activation mechanism of platelet ?IIb?3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations. Proteins. 2014;82:3231-3240 pubmed publisher
  79. Prandini M, Denarier E, Frachet P, Uzan G, Marguerie G. Isolation of the human platelet glycoprotein IIb gene and characterization of the 5' flanking region. Biochem Biophys Res Commun. 1988;156:595-601 pubmed
    ..The gene for the GPIIb subunit is only active in megakaryocytic cell type. We have isolated this gene from a genomic library...
  80. Lincoff A. Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization. Am J Cardiol. 1998;82:36P-42P pubmed
    ..Excessive bleeding risk associated with these agents may be markedly diminished without loss of efficacy by reduction in conjunctive heparin dosing. ..
  81. Park K, Chung H, Lee K, Park I, Kim S, Kim H. Novel and recurrent mutations of ITGA2B and ITGB3 genes in Korean patients with Glanzmann thrombasthenia. Pediatr Blood Cancer. 2012;59:335-8 pubmed publisher
    ..R584X];[Q778P]). The c.2975delA mutation was a novel frameshift mutation of ITGA2B. Although from a limited number of patients, these results suggests c.1913+5G>T of ITGB3 is a recurrent mutation in Korean patients with GT. ..
  82. Hu L, Du L, Zhao Y, Li W, Ouyang Q, Zhou D, et al. Modeling Glanzmann thrombasthenia using patient specific iPSCs and restoring platelet aggregation function by CD41 overexpression. Stem Cell Res. 2017;20:14-20 pubmed publisher
    ..GT-iPSCs could be successfully differentiated into platelets (GT-iPS-platelets). GT-iPS-platelets were CD41-/CD42b+/CD61- and were platelet activation marker (PAC-1) negative after adenosine diphosphate (ADP) activation...
  83. Pongracz E, Tordai A, Csornai M, Nagy Z. [Platelet glycoprotein IIb/IIIa (LeuPro 33) polymorphism in stroke patients]. Orv Hetil. 2001;142:781-5 pubmed
    ..Carotid stenosis with polymorphism is a risk factor for young patients. PLA variant together with prothrombin gene polymorphism results very high risk for stroke. ..
  84. Iwasaki K, Mitsuoka K, Fujiyoshi Y, Fujisawa Y, Kikuchi M, Sekiguchi K, et al. Electron tomography reveals diverse conformations of integrin alphaIIbbeta3 in the active state. J Struct Biol. 2005;150:259-67 pubmed
    ..Our results demonstrate that electron tomography can be used to classify complexes with a flexible structure such as integrins. ..
  85. Pavkovic M, Petlichkovski A, Strezova A, Arsov T, Trajkov D, Spiroski M. Gene frequencies of human platelet antigens in the Macedonian population. Tissue Antigens. 2006;67:241-6 pubmed
    ..091 for HPA-5b. Results of our study were not significantly different from those reported in the other European studies. Our population displayed the highest frequency for HPA-2b allele (0.148) reported among European population. ..
  86. Mattheij N, Gilio K, van Kruchten R, Jobe S, Wieschhaus A, Chishti A, et al. Dual mechanism of integrin ?IIb?3 closure in procoagulant platelets. J Biol Chem. 2013;288:13325-36 pubmed publisher
    ..Inactivation of integrin ?IIb?3 reverses platelet aggregate formation upon coagulation...
  87. Havasi V, Komlosi K, Bene J, Melegh B. Increased prevalence of glycoprotein IIb/IIIa Leu33Pro polymorphism in term infants with grade I intracranial haemorrhage. Neuropediatrics. 2006;37:67-71 pubmed
  88. Metcalf D, Kulp D, Bennett J, Degrado W. Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer. J Mol Biol. 2009;392:1087-101 pubmed publisher
    ..These results demonstrate that multiple approaches converged on the same structure of the resting integrin's TM heterodimer, and this conformation likely reflects the integrin's native structure. ..
  89. Fiore M, Pillois X, Nurden P, Nurden A, Austerlitz F. Founder effect and estimation of the age of the French Gypsy mutation associated with Glanzmann thrombasthenia in Manouche families. Eur J Hum Genet. 2011;19:981-7 pubmed publisher
    ..The estimated age of this founder mutation was 300-400 years (range 255-552 years). Thus, all carriers of the French Gypsy mutation c.1544+1G>A at intron 15 descended from a common ancestor 300-400 years ago. ..
  90. Winter W, Flax S, Harris N. Coagulation Testing in the Core Laboratory. Lab Med. 2017;48:295-313 pubmed publisher
    ..Platelet-derived ADP and thromboxane activate non-adhered platelets via their GPIIb/IIIa receptors, allowing these platelets to participate in platelet aggregation...
  91. Boehlen F, Bulla O, Michel M, Reber G, de Moerloose P. HPA-genotyping and antiplatelet antibodies in female blood donors. Hematol J. 2003;4:441-4 pubmed
    ..Although none of the recipients developed passive alloimmune thrombocytopenia, this aspect of blood transfusion safety should be addressed by a large prospective trial. ..
  92. Keane C, Petersen H, Reynolds K, Newman D, Cox D, Jenkinson H, et al. Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii. Arterioscler Thromb Vasc Biol. 2010;30:2408-15 pubmed publisher
    ..Streptococcus gordonii binding to the ?(IIb)?(3)/Fc?RIIa integrin/ITAM signaling complex results in platelet activation that likely contributes to the thrombotic complications of infective endocarditis. ..