CD3E

Summary

Gene Symbol: CD3E
Description: CD3e molecule
Alias: IMD18, T3E, TCRE, T-cell surface glycoprotein CD3 epsilon chain, CD3-epsilon, CD3e antigen, epsilon polypeptide (TiT3 complex), CD3e molecule, epsilon (CD3-TCR complex), T-cell antigen receptor complex, epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain
Species: human
Products:     CD3E

Top Publications

  1. Ruegg C, Strand M. A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx. Cell Immunol. 1991;137:1-13 pubmed
  2. Bruyns E, Marie Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, et al. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane. J Exp Med. 1998;188:561-75 pubmed
    ..Thus, TRIM represents a TCR-associated transmembrane adaptor protein which is likely involved in targeting of intracellular signaling proteins to the plasma membrane after triggering of the TCR. ..
  3. De Saint Basile G, Geissmann F, Flori E, Uring Lambert B, Soudais C, Cavazzana Calvo M, et al. Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3. J Clin Invest. 2004;114:1512-7 pubmed
    ..for a mutation in the CD3D gene, and patients from the third family were homozygous for a mutation in the CD3E gene...
  4. Schindler M, Munch J, Kutsch O, Li H, Santiago M, Bibollet Ruche F, et al. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell. 2006;125:1055-67 pubmed
    ..This function was lost during viral evolution in a lineage that gave rise to HIV-1 and may have predisposed the simian precursor of HIV-1 for greater pathogenicity in humans...
  5. Sigalov A, AIVAZIAN D, Uversky V, Stern L. Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits. Biochemistry. 2006;45:15731-9 pubmed
    ..The implications of these results for transmembrane signal transduction by immune receptors are discussed. ..
  6. Munch J, Rajan D, Schindler M, Specht A, Rücker E, Novembre F, et al. Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses. J Virol. 2007;81:13852-64 pubmed
  7. Ariën K, Verhasselt B. HIV Nef: role in pathogenesis and viral fitness. Curr HIV Res. 2008;6:200-8 pubmed
    ..Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness. ..
  8. Malim M, Emerman M. HIV-1 accessory proteins--ensuring viral survival in a hostile environment. Cell Host Microbe. 2008;3:388-98 pubmed publisher
    ..Broadly speaking, the HIV-1 accessory proteins modify the local environment within infected cells to ensure viral persistence, replication, dissemination, and transmission. ..
  9. Sang Y, Wang Y, Ni H, Cazalé A, She Y, Peeters N, et al. The Ralstonia solanacearum type III effector RipAY targets plant redox regulators to suppress immune responses. Mol Plant Pathol. 2018;19:129-142 pubmed publisher
    ..Most bacterial plant pathogens employ a type III secretion system to inject type III effector (T3E) proteins inside plant cells, where they contribute to the pathogen-induced alteration of plant physiology...

More Information

Publications176 found, 100 shown here

  1. Banning C, Votteler J, Hoffmann D, Koppensteiner H, Warmer M, Reimer R, et al. A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells. PLoS ONE. 2010;5:e9344 pubmed publisher
  2. Fergusson R, Lethaby A, Shepperd S, Farquhar C. Endometrial resection and ablation versus hysterectomy for heavy menstrual bleeding. Cochrane Database Syst Rev. 2013;:CD000329 pubmed publisher
    ..Several less invasive surgical techniques (e.g. transcervical resection of the endometrium (TCRE), laser approaches) and various methods of endometrial ablation have been developed with the purpose of improving ..
  3. Hart M, Walch Rückheim B, Friedmann K, Rheinheimer S, Tänzer T, Glombitza B, et al. miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling. Cell Death Dis. 2019;10:46 pubmed publisher
    ..Functional analysis identified five target genes of miR-34a including PLCG1, CD3E, PIK3CB, TAB2, and NFΚBIA...
  4. Omar Zaki S, Katas H, Hamid Z. Lineage-related and particle size-dependent cytotoxicity of chitosan nanoparticles on mouse bone marrow-derived hematopoietic stem and progenitor cells. Food Chem Toxicol. 2015;85:31-44 pubmed publisher
    ..on HSCs (Sca-1(+)), myeloid-committed progenitors (CD11b(+), Gr-1(+)), and lymphoid-committed progenitors (CD45(+), CD3e(+)). At 24 h incubation, MBMCs' viability was not affected by CSNPs...
  5. Yadav A, Kumar A, Das M, Tripathi A. Sodium benzoate, a food preservative, affects the functional and activation status of splenocytes at non cytotoxic dose. Food Chem Toxicol. 2016;88:40-7 pubmed publisher
    ..SB did not affect the relative expression of CD3e or CD4 molecules following 72 h exposure, however, it downregulated the relative expression of CD8 co-receptor...
  6. Luzzati A, Giacomini E, Giordani L, Pugliese O, Viora M, Chersi A. The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope. Immunol Lett. 1992;33:307-14 pubmed
    ..Moreover, they are of potential relevance for the development of immunoprophylactic and therapeutic strategies. ..
  7. Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G. Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. J Clin Invest. 1990;86:2117-24 pubmed
  8. Sheng Fowler L, Tu W, Fu H, Murata H, Lanning L, Foseh G, et al. A mouse strain defective in both T cells and NK cells has enhanced sensitivity to tumor induction by plasmid DNA expressing both activated H-Ras and c-Myc. PLoS ONE. 2014;9:e108926 pubmed publisher
    ..In this paper, we demonstrate that the newborn CD3 epsilon transgenic mouse, which is defective in both T-cell and NK-cell functions, can detect the oncogenic activity of ..
  9. Chen S, Lee L, Fisher T, Jessen B, Elliott M, Evering W, et al. Combination of 4-1BB agonist and PD-1 antagonist promotes antitumor effector/memory CD8 T cells in a poorly immunogenic tumor model. Cancer Immunol Res. 2015;3:149-60 pubmed publisher
    ..immune response was induced as indicated by the increased CD8(+)/Treg ratio and the enrichment of genes such as Cd3e, Cd8a, Ifng, and Eomes...
  10. Shiraiwa H, Narita A, Kamata Sakurai M, Ishiguro T, Sano Y, Hironiwa N, et al. Engineering a bispecific antibody with a common light chain: Identification and optimization of an anti-CD3 epsilon and anti-GPC3 bispecific antibody, ERY974. Methods. 2019;154:10-20 pubmed publisher
    ..Furthermore, we describe some tips for de-risking the antibody when engineering a T cell redirecting antibody. ..
  11. Bongers M. Hysteroscopy and heavy menstrual bleeding (to cover TCRE and second-generation endometrial ablation). Best Pract Res Clin Obstet Gynaecol. 2015;29:930-9 pubmed publisher
    ..The most important prognostic parameters are age (satisfaction increases with age) and preoperative dysmenorrhoea (decreases satisfaction). ..
  12. Pishvaian M, Morse M, McDevitt J, Norton J, Ren S, Robbie G, et al. Phase 1 Dose Escalation Study of MEDI-565, a Bispecific T-Cell Engager that Targets Human Carcinoembryonic Antigen, in Patients With Advanced Gastrointestinal Adenocarcinomas. Clin Colorectal Cancer. 2016;15:345-351 pubmed publisher
    MEDI-565, a bispecific, single-chain antibody targeting human carcinoembryonic antigen on tumor cells and the CD3 epsilon subunit of the human T-cell receptor complex, showed antitumor activity in carcinoembryonic antigen-expressing ..
  13. Aitio O, Hellman M, Kesti T, Kleino I, Samuilova O, Pääkkönen K, et al. Structural basis of PxxDY motif recognition in SH3 binding. J Mol Biol. 2008;382:167-78 pubmed publisher
    ..These finding have direct implications also for understanding the atypical binding specificity of the amino-terminal SH3 of the Nck family proteins. ..
  14. Wei H, Chakravarthy S, Mathieu J, Helmann T, Stodghill P, Swingle B, et al. Pseudomonas syringae pv. tomato DC3000 Type III Secretion Effector Polymutants Reveal an Interplay between HopAD1 and AvrPtoB. Cell Host Microbe. 2015;17:752-62 pubmed publisher
    ..the two-tiered plant innate immune system by injecting a complex repertoire of type III secretion effector (T3E) proteins...
  15. Hayashi S, Akiyama R, Wong J, Tahara N, Kawakami H, Kawakami Y. Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development. PLoS Genet. 2016;12:e1006138 pubmed publisher
    ..We show that conditional inactivation of Gata6 prior to limb outgrowth by the Tcre deleter causes preaxial polydactyly, the formation of an anterior extra digit, in hindlimbs...
  16. Guo H, Hu C, Yan P, Li Z, Chen Z. [Analysis of the storage time in paraformaldehyde-fixed T cells and their subsets in Kunming mice]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:460-464 pubmed
    Objective To determine the expiration dates of CD3e+CD4+ T and CD3e+CD8a+ T lymphocytes of Kunming mice...
  17. Sato A, Ueno H, Fusegi M, Kaneko S, Kohno K, Virgona N, et al. A Succinate Ether Derivative of Tocotrienol Enhances Dickkopf-1 Gene Expression through Epigenetic Alterations in Malignant Mesothelioma Cells. Pharmacology. 2018;102:26-36 pubmed publisher
    ..We have reported that a succinate ether derivative of α-tocotrienol (T3E) has potent cytotoxic effects in MM cells...
  18. Dürrbaum Landmann I, Kaltenhäuser E, Flad H, Ernst M. HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro. J Leukoc Biol. 1994;55:545-51 pubmed
    ..These effects of isolated gp120 on monocyte immune functions in vitro might contribute to the understanding of the pathophysiology of HIV-1 infection in vivo. ..
  19. Stanners J, Kabouridis P, McGuire K, Tsoukas C. Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling. J Biol Chem. 1995;270:30635-42 pubmed
    ..exchange among the 42-kDa G protein alpha subunits of the G alpha q/11 family, their physical association with CD3 epsilon, and the G alpha 11-dependent activation of phospholipase C beta...
  20. Xu C, Call M, Wucherpfennig K. A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor. J Biol Chem. 2006;281:36977-84 pubmed
    ..The three-chain interaction theme first established for the TM domains thus extends into the membrane-proximal domains of TCRalpha-CD3deltaepsilon and TCRbeta-CD3gammaepsilon. ..
  21. Foster J, Garcia J. HIV-1 Nef: at the crossroads. Retrovirology. 2008;5:84 pubmed publisher
    ..Finally, we conclude that inhibiting the CD4 downregulation function is the most promising Nef-targeted approach for developing a new anti-viral as a contribution to combating AIDS. ..
  22. Bello R, Feito M, Ojeda G, Portoles P, Rojo J. N-terminal negatively charged residues in CD3varepsilon chains as a phylogenetically conserved trait potentially yielding isoforms with different isoelectric points: analysis of human CD3varepsilon chains. Immunol Lett. 2009;126:8-15 pubmed publisher
  23. Cohen T, Cohen S, Antonovsky N, Cohen I, Shai Y. HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation. PLoS Pathog. 2010;6:e1001085 pubmed publisher
    ..However, the inhibitory mechanism of gp41 TMD differs from that of the TCRalpha TMD and also from the other two known immunosuppressive regions within gp41. ..
  24. Paensuwan P, Ngoenkam J, Khamsri B, Preechanukul K, Sanguansermsri D, Pongcharoen S. Evidence for inducible recruitment of Wiskott-Aldrich syndrome protein to T cell receptor-CD3 complex in Jurkat T cells. Asian Pac J Allergy Immunol. 2015;33:189-95 pubmed publisher
    ..The present findings provide an alternative mechanism of WASp recruitment to the site of TCR activation that may be involved in recruitment of Nck. ..
  25. Chakravarthy S, Huot B, Kvitko B. Effector Translocation: Cya Reporter Assay. Methods Mol Biol. 2017;1615:473-487 pubmed publisher
    An accurate and complete roster of the Type III effector (T3E) proteins translocated by the P. syringae Type III secretion system (T3SS) into host cells is critical to understanding the pathogen's interactions with plants...
  26. Luzzati A, Giacomini E, Giordani L, Viora M, Chersi A, Camponeschi B, et al. An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex. Cell Immunol. 1994;156:286-95 pubmed
  27. Hubert P, Bismuth G, Korner M, Debre P. HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling. Eur J Immunol. 1995;25:1417-25 pubmed
    ..Supporting this hypothesis, gp120 inhibits CD3-linked kinase activity as shown by the inhibition of the phosphorylation of CD3 chains, leading to the inhibition of subsequent signal transduction. ..
  28. Nakano H, Yamazaki T, Miyatake S, Nozaki N, Kikuchi A, Saito T. Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex. J Biol Chem. 1996;271:6483-9 pubmed
    ..TCR)-CD3 complex is composed of six different subunits: TCR alpha and TCR beta and CD3 gamma, CD3 delta, CD3 epsilon, and CD3 eta...
  29. Zubiaur M, Fernández O, Ferrero E, Salmeron J, Malissen B, Malavasi F, et al. CD38 is associated with lipid rafts and upon receptor stimulation leads to Akt/protein kinase B and Erk activation in the absence of the CD3-zeta immune receptor tyrosine-based activation motifs. J Biol Chem. 2002;277:13-22 pubmed
  30. Pace M, Graf E, Agosto L, Mexas A, Male F, Brady T, et al. Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency. PLoS Pathog. 2012;8:e1002818 pubmed publisher
    ..These results have implications for therapies targeting the latent reservoir and suggest that some latent cells could be cleared by a robust immune response. ..
  31. Üstün S, Börnke F. The Xanthomonas campestris type III effector XopJ proteolytically degrades proteasome subunit RPT6. Plant Physiol. 2015;168:107-19 pubmed publisher
    Many animal and plant pathogenic bacteria inject type III effector (T3E) proteins into their eukaryotic host cells to suppress immunity...
  32. Bacac M, Fauti T, Sam J, Colombetti S, Weinzierl T, Ouaret D, et al. A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors. Clin Cancer Res. 2016;22:3286-97 pubmed publisher
    ..Its format incorporates bivalent binding to CEA, a head-to-tail fusion of CEA- and CD3e-binding Fab domains and an engineered Fc region with completely abolished binding to FcγRs and C1q...
  33. Wong S, Moore S, Orisio S, Millward A, Demaine A. Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11. Clin Exp Immunol. 1991;83:69-73 pubmed
    ..chromosome 11q23 and report here the results of restriction fragment length polymorphism (RFLP) analysis of the CD3 epsilon locus of 168 Caucasoid patients with type I diabetes...
  34. Ott M, Lovett J, Mueller L, Verdin E. Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors. J Immunol. 1998;160:2872-80 pubmed
    ..The effect of Tat101 on CD28REs in the IL-8 promoter and the subsequent up-regulation of IL-8 secretion is likely to contribute to the immune dysregulation observed during HIV-1 infection. ..
  35. Deford Watts L, Tassin T, Becker A, Medeiros J, Albanesi J, Love P, et al. The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions. J Immunol. 2009;183:1055-64 pubmed publisher
    The CD3 epsilon subunit of the TCR complex contains two defined signaling domains, a proline-rich sequence and an ITAM. We identified a third signaling sequence in CD3 epsilon, termed the basic-rich stretch (BRS)...
  36. Chow P, Abdul Hamid Z, Chan K, Inayat Hussain S, Rajab N. Lineage-related cytotoxicity and clonogenic profile of 1,4-benzoquinone-exposed hematopoietic stem and progenitor cells. Toxicol Appl Pharmacol. 2015;284:8-15 pubmed publisher
    ..Expression of cellular surface antigens for HSC (Sca-1), myeloid (Gr-1, CD11b), and lymphoid (CD45, CD3e) populations were confirmed by flow cytometry...
  37. He Y, Rangarajan S, Kerzic M, Luo M, Chen Y, Wang Q, et al. Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR. J Biol Chem. 2015;290:19796-805 pubmed publisher
    ..We further correlate structural results from NMR with mutational data on TCR-CD3 interactions from cell-based assays. ..
  38. Preite S, Baumjohann D, Foglierini M, Basso C, Ronchi F, Fernandez Rodriguez B, et al. Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells. Eur J Immunol. 2015;45:3010-21 pubmed publisher
    We previously reported that Cd3e-deficient mice adoptively transferred with CD4(+) T cells generate high numbers of T follicular helper (Tfh) cells, which go on to induce a strong B-cell and germinal center (GC) reaction...
  39. Mutka A, Fentress S, Sher J, Berry J, Pretz C, Nusinow D, et al. Quantitative, Image-Based Phenotyping Methods Provide Insight into Spatial and Temporal Dimensions of Plant Disease. Plant Physiol. 2016;172:650-660 pubmed
    ..manihotis (Xam). We generated Xam strains in which individual predicted type III effector (T3E) genes were mutated and applied multiple imaging approaches to investigate the role of these proteins in bacterial ..
  40. Christiansen U, Hansen M, Lauszus F. Hysterectomy is not associated with de-novo urinary incontinence: A ten-year cohort study. Eur J Obstet Gynecol Reprod Biol. 2017;215:175-179 pubmed publisher
    ..with a hysterectomy, 89 with laparoscopic cholecystectomy (LC), and 201 with transcervical endometrial resection (TCRE). Significant incontinence was UI at least once a week...
  41. Luzzati A, Boirivant M, Giacomini E, Giordani L, Di Modugno F, Chersi A. Interferon-gamma (IFN-gamma) can counteract the in vitro inhibitory effect of an HIV p24 immunosuppressive heptapeptide. Clin Exp Immunol. 1996;105:403-8 pubmed
    ..Thus, although the Ch7 immunosuppressive effect may not be directly related to a decreased production of IFN-gamma, an increased level of this cytokine is certainly able to counteract the negative effect of the peptide. ..
  42. Gary Gouy H, Lang V, Sarun S, Boumsell L, Bismuth G. In vivo association of CD5 with tyrosine-phosphorylated ZAP-70 and p21 phospho-zeta molecules in human CD3+ thymocytes. J Immunol. 1997;159:3739-47 pubmed
    ..Although both p21 and p23 tyrosine-phosphorylated forms of zeta as well as phospho-CD3 epsilon molecules were constitutively present in human thymocytes and could be immunoprecipitated with ZAP-70- or CD3 ..
  43. Corcoran L, Ferrero I, Vremec D, Lucas K, Waithman J, O Keeffe M, et al. The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells. J Immunol. 2003;170:4926-32 pubmed
    ..whether CD8(+) or CD8(-), contained IgH D-J rearrangements and splenic conventional DC expressed very little CD3 epsilon or pre-T alpha mRNA...
  44. Bibollet Ruche F, McKinney B, Duverger A, Wagner F, Ansari A, Kutsch O. The quality of chimpanzee T-cell activation and simian immunodeficiency virus/human immunodeficiency virus susceptibility achieved via antibody-mediated T-cell receptor/CD3 stimulation is a function of the anti-CD3 antibody isotype. J Virol. 2008;82:10271-8 pubmed publisher
    ..Our results thus imply that prior to studying possible differences between human and chimpanzee T-cell activation, a relevant model of chimpanzee T cell activation needs to be established...
  45. Markle T, Philip M, Brockman M. HIV-1 Nef and T-cell activation: a history of contradictions. Future Virol. 2013;8: pubmed publisher
  46. Dickson M, Ludbrook V, Perry H, Wilson P, Garthside S, Binks M. A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development. Inflamm Res. 2015;64:171-83 pubmed publisher
    ..mRNA markers representing inflammatory cells [e.g., CD14, CD3E (p < 0.0001)] and mRNAs encoding genes regulated by type 1 interferon (IFN) [e.g., MX1, OAS1and CXCL10 (p < 0...
  47. Besançon A, Goncalves T, Valette F, Dahllöf M, Mandrup Poulsen T, Chatenoud L, et al. Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice. Diabetologia. 2018;61:389-398 pubmed publisher
    ..NOD mice transgenic for the human CD3ε (also known as CD3E) chain (NOD-huCD3ε) were treated for recent-onset diabetes with oral givinostat, subtherapeutic doses of humanised ..
  48. Lonjon F, Peeters N, Genin S, Vailleau F. In Vitro and In Vivo Secretion/Translocation Assays to Identify Novel Ralstonia solanacearum Type 3 Effectors. Methods Mol Biol. 2018;1734:209-222 pubmed publisher
    ..solanacearum species complex (RSSC). Up to 113 orthologous groups defining T3E genes have been identified among the RSSC strains sequenced to date. The increasing number of R...
  49. Kesti T, Ruppelt A, Wang J, Liss M, Wagner R, Tasken K, et al. Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon. J Immunol. 2007;179:878-85 pubmed
    ..Thus, phosphorylation of Y166 serves as a molecular switch during T cell activation that determines the capacity of CD3epsilon to interact with either SH3 or SH2 domain-containing proteins. ..
  50. Arhel N, Lehmann M, Clauss K, Nienhaus G, Piguet V, Kirchhoff F. The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses. J Clin Invest. 2009;119:2965-75 pubmed publisher
    ..The resulting differences in the levels of T cell activation and apoptosis may play a role in the pathogenesis of AIDS...
  51. Almansa R, Heredia Rodríguez M, Gomez Sanchez E, Andaluz Ojeda D, Iglesias V, Rico L, et al. Transcriptomic correlates of organ failure extent in sepsis. J Infect. 2015;70:445-56 pubmed publisher
    ..Genes involved in T cell (LCK, CD3G, CD3D, ZAP70, ICOS, CD3E, CD28, IL2RB, CD8B, CD8A, CD40LG, IL23A, CCL5, SH2D1A, ITK, CD247, TBX21, GATA3, CCR7, LEF1, STAT4) and NK cell ..
  52. Millar R, Friedlingstein P. The utility of the historical record for assessing the transient climate response to cumulative emissions. Philos Trans A Math Phys Eng Sci. 2018;376: pubmed publisher
    ..uncertainties to estimate the all-forcing or 'effective' transient climate response to cumulative emissions (TCRE) from the observational record...
  53. Waaijer S, Warnders F, Stienen S, Friedrich M, Sternjak A, Cheung H, et al. Molecular Imaging of Radiolabeled Bispecific T-Cell Engager 89Zr-AMG211 Targeting CEA-Positive Tumors. Clin Cancer Res. 2018;24:4988-4996 pubmed publisher
    ..AMG 211, a bispecific T-cell engager (BiTE) antibody construct, targets carcinoembryonic antigen (CEA) and the CD3 epsilon subunit of the human T-cell receptor...
  54. Miwa H, Okazaki S. How effectors promote beneficial interactions. Curr Opin Plant Biol. 2017;38:148-154 pubmed publisher
    ..In addition, rhizobial T3E can promote root nodule symbiosis by directly activating Nod factor signaling, which bypasses Nod factor perception...
  55. Martinez N, Vallerskog T, West K, Nunes Alves C, Lee J, Martens G, et al. Chromatin decondensation and T cell hyperresponsiveness in diabetes-associated hyperglycemia. J Immunol. 2014;193:4457-68 pubmed publisher
    ..levels of Th1, Th2, and Th17 cytokines and proliferated more than T cells from normoglycemic controls after anti-CD3e or Ag stimulation...
  56. Chia L, Walsh N, Martin T, Sims N. Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes. Bone. 2015;72:34-42 pubmed publisher
    ..To resolve this we stained DMP1-GFP cells for haematopoietic lineage (Lin) surface markers (CD2, CD3e, CD4, CD45, CD5, CD8, CD11b, B220, Gr1, Ter119) and CD31...
  57. Seto D, Koulena N, Lo T, Menna A, Guttman D, Desveaux D. Expanded type III effector recognition by the ZAR1 NLR protein using ZED1-related kinases. Nat Plants. 2017;3:17027 pubmed publisher
    ..the Arabidopsis ZAR1 NLR protein requires the ZRK3 kinase to recognize the Pseudomonas syringae type III effector (T3E) HopF2a...
  58. Galbavy W, Kaczocha M, Puopolo M, Liu L, Rebecchi M. Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. PLoS ONE. 2015;10:e0134394 pubmed publisher
    ..Results showed that CD2, CD3e, CD68, CD45, TNF-α, IL6, CCL2, ATF3 and TGFβ1 mRNA levels were substantially elevated in LSC from naïve ..
  59. Okada H, Momota H, Okada N, Okamoto T, Azuma T. Elimination of HIV-infected cells by lymphocytes armed with a bifunctional antibody to gp120 of HIV and CD3. Immunol Lett. 1993;38:195-9 pubmed
    ..This suggests that HIV antigen-positive cells could be eliminated by administration of BFA-armed lymphocytes leaving HIV patients with only dormantly infected or low producer cells. ..
  60. Wange R, Malek S, Desiderio S, Samelson L. Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells. J Biol Chem. 1993;268:19797-801 pubmed
    ..we report that the tandem SH2 domains of ZAP-70, expressed as a fusion protein, bind to tyrosine-phosphorylated CD3 epsilon and TCR zeta from activated Jurkat T cell lysates...
  61. de Aos I, Metzger M, Exley M, Dahl C, Misra S, Zheng D, et al. Tyrosine phosphorylation of the CD3-epsilon subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells. J Biol Chem. 1997;272:25310-8 pubmed
    ..The data also support a model in which a single CD3 subunit can recruit distinct effector molecules by means of TCR-mediated differential ITAM phosphorylation. ..
  62. Heigele A, Camerini D, van t Wout A, Kirchhoff F. Viremic long-term nonprogressive HIV-1 infection is not associated with abnormalities in known Nef functions. Retrovirology. 2014;11:13 pubmed publisher
    ..Thus, the lack of chronic immune activation and disease progression in HIV-1-infected VNPs is apparently not associated with unusual functional properties of the accessory viral Nef protein. ..
  63. Sigalov A, Aivazian D, Stern L. Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif. Biochemistry. 2004;43:2049-61 pubmed
    ..Phosphorylation of zeta(cyt) and FcepsilonRIgamma(cyt) does not significantly alter their oligomerization behavior. The implications of these results for transmembrane signaling and cellular activation by immune receptors are discussed. ..
  64. Ye Lin Y, Alberola Rubio J, Prats Boluda G, Perales A, Desantes D, Garcia Casado J. Feasibility and analysis of bipolar concentric recording of electrohysterogram with flexible active electrode. Ann Biomed Eng. 2015;43:968-76 pubmed publisher
    ..examine the feasibility of picking up surface EHG signals using a new flexible tripolar concentric ring electrode (TCRE), and to compare these signals with conventional bipolar recordings...
  65. Sato A, Ueno H, Takase A, Ando A, Sekine Y, Yano T. Cytotoxicity Induced by a Redox-silent Analog of Tocotrienol in Human Mesothelioma H2452 Cell Line via Suppression of Cap-dependent Protein Translation. Anticancer Res. 2016;36:1527-33 pubmed
    ..We previously reported that a redox-silent analog of ?-tocotrienol, 6-O-carboxypropyl-?-tocotrienol (T3E) induces potent cytotoxicity against human MM cells...
  66. Dudnik A, Dudler R. Virulence determinants of Pseudomonas syringae strains isolated from grasses in the context of a small type III effector repertoire. BMC Microbiol. 2014;14:304 pubmed publisher
    ..The aim of this study was to analyze the contribution of various known virulence factors in the context of a small T3E repertoire...
  67. Panigrahi G, Yadav A, Mandal P, Tripathi A, Das M. Immunomodulatory potential of Rhein, an anthraquinone moiety of Cassia occidentalis seeds. Toxicol Lett. 2016;245:15-23 pubmed publisher
    ..Lymphocyte receptor expression analysis revealed that Rhein exposure significantly down regulate the expression of CD3e, CD4, CD8, CD28, CD69 molecules in T-cells...
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    ..Collectively, our data advance our understanding of the molecular organization of the TCR-CD3 complex, and provides a conceptual framework for the TCR activation mechanism. ..
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    ..variations of SCID by using SmartChip-TE technology, and a novel pathogenic frameshift variant was found in the CD3E gene. Sanger sequencing has confirmed the segregation of the variant among patients...
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    ..We show that Pst activates autophagy in a type III effector (T3E)-dependent manner and stimulates the autophagic removal of proteasomes (proteaphagy) to support bacterial ..
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    ..The TCR/CD3 complex is assembled after a series of pairwise interactions involving the formation of dimers of CD3 epsilon with either CD3 gamma or CD3 delta...
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    ..strain NGR234 is multiply phosphorylated in eukaryotic cells and that this T3E suppresses responses mediated by mitogen-activated protein (MAP) kinase signaling in yeast (mating pheromone ..
  77. Rowe J, Delmonte O, Keles S, Stadinski B, Dobbs A, Henderson L, et al. Patients with CD3G mutations reveal a role for human CD3γ in Treg diversity and suppressive function. Blood. 2018;: pubmed publisher
    ..In humans, CD3D, CD3E, and CD3Z gene defects are a cause of severe immune deficiency and present early in life with increased ..
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    ..association rate and equilibrium binding constants for the ZAP-70 and syk SH2 domains were determined for the CD3 epsilon ITAM. Both PTKs bound with ka and Kd values of 5 x 10(6) M-1.sec-1 and approximately 25 nM, respectively...
  80. Fasseu M, Aplan P, Chopin M, Boissel N, Bories J, Soulier J, et al. p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis. Blood. 2007;110:2610-9 pubmed
    ..We also show that the CD3epsilon-mediated signal transduction pathway is essential for this transformation process, since the TAL1xLMO1xCD3epsilon-deficient mice do not develop T-ALL for up to 1 year. ..
  81. Wu J, Katrekar A, Honigberg L, Smith A, Conn M, Tang J, et al. Identification of substrates of human protein-tyrosine phosphatase PTPN22. J Biol Chem. 2006;281:11002-10 pubmed
    ..Native PTPN22 also dephosphorylated TCRzeta in vitro and in cells, and its substrate trap variant co-immunoprecipitated with TCRzeta when both were coexpressed in 293T cells, establishing TCRzeta as a direct substrate of PTPN22. ..
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    ..Altogether, these data demonstrate that Nef interferes with the differentiation of a primitive lymphoid human precursor with a T/NK potential. ..
  83. Xue P, Gao L, Xiao S, Zhang G, Xiao M, Zhang Q, et al. Genetic Polymorphisms in XRCC1, CD3EAP, PPP1R13L, XPB, XPC, and XPF and the Risk of Chronic Benzene Poisoning in a Chinese Occupational Population. PLoS ONE. 2015;10:e0144458 pubmed publisher
    ..Nine single nucleotide polymorphisms (SNPs) of XRCC1 (X-ray repair cross-complementing 1), CD3EAP (CD3e molecule, epsilon associated protein), PPP1R13L (protein phosphatase 1, regulatory subunit 13 like), XPB (Xeroderma ..
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    Most Gram-negative phytopathogenic bacteria inject type III effector (T3E) proteins into plant cells to manipulate signaling pathways to the pathogen's benefit...
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    ..The data further indicate that gamma epsilon and delta epsilon complexes interact directly with the TcR chains. Based on the observations a model for the structure of the TcR-CD3 is presented and discussed. ..
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    ..This sequence relationship adds interest to previous findings that the T3 chains are genetically linked to N-CAM and Thy-1 antigen on band q23 of human chromosome 11. ..
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    ..better understand the maturational stages during T-cell development, we studied the expression of CD3 delta and CD3 epsilon genes, as well as the presence of TCR gene rearrangements, within CD3-CD16+ NK clones derived from thymic ..
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    ..using flow cytometry as well as immunochemical means both before and after stimulation with anti-TCR-beta, anti-CD3 epsilon, anti-CD2, staphylococcal enterotoxin B, and ionomycin...
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    ..Local changes in the lipid composition of TCR microclusters thus render the CD3? cytoplasmic domain accessible during early stages of T cell activation. ..
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    ..The 'guard model' describes the mechanism of T3E perception by plants, whereby NLRs monitor host proteins ('sensors') for T3E-induced perturbations...
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    ..To search for targets of WtsE, an AvrE-family T3E from the maize pathogen Pantoea stewartii subsp...