CD38

Summary

Gene Symbol: CD38
Description: CD38 molecule
Alias: ADPRC 1, ADPRC1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, CD38 antigen (p45), NAD(+) nucleosidase, cluster of differentiation 38, cyclic ADP-ribose hydrolase 1, ecto-nicotinamide adenine dinucleotide glycohydrolase
Species: human
Products:     CD38

Top Publications

  1. Damle R, Temburni S, Calissano C, Yancopoulos S, Banapour T, Sison C, et al. CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood. 2007;110:3352-9 pubmed
    ..The present study addresses the cell-cycling status of CLL cells, focusing on those leukemic cells expressing CD38, a molecule involved in signaling and activation that also serves as a prognostic marker in this disease...
  2. Deaglio S, Vaisitti T, Billington R, Bergui L, Omede P, Genazzani A, et al. CD38/CD19: a lipid raft-dependent signaling complex in human B cells. Blood. 2007;109:5390-8 pubmed
    The present work deals with the mechanisms of signal transduction mediated via CD38 in normal and neoplastic human B lymphocytes...
  3. Patten P, Buggins A, Richards J, Wotherspoon A, Salisbury J, Mufti G, et al. CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment. Blood. 2008;111:5173-81 pubmed publisher
    ..The prognosis of patients with CLL may be predicted using a number of biomarkers, including the level of CD38 expression at the leukemic cell surface...
  4. Liu Q, Kriksunov I, Graeff R, Munshi C, Lee H, Hao Q. Crystal structure of human CD38 extracellular domain. Structure. 2005;13:1331-9 pubmed
    Human CD38 is a multifunctional protein involved in diverse functions...
  5. Jude J, Solway J, Panettieri R, Walseth T, Kannan M. Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2010;299:L879-90 pubmed publisher
    The ADP-ribosyl cyclase activity of CD38, a membrane protein expressed in human airway smooth muscle (ASM) cells, generates cyclic ADP-ribose (cADPR), a Ca²(+)-mobilizing agent...
  6. Deaglio S, Morra M, Mallone R, Ausiello C, Prager E, Garbarino G, et al. Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member. J Immunol. 1998;160:395-402 pubmed
    Human CD38 is a cell surface molecule involved in the regulation of lymphocyte adhesion to endothelial cells. This suggests that HUVEC bear a ligand(s) for CD38 on the cell surface...
  7. Guse A. Cyclic ADP-ribose: a novel Ca2+-mobilising second messenger. Cell Signal. 1999;11:309-16 pubmed
  8. Funaro A, Malavasi F. Human CD38, a surface receptor, an enzyme, an adhesion molecule and not a simple marker. J Biol Regul Homeost Agents. 1999;13:54-61 pubmed
    Human CD38 is a 45 kDa type II trans-membrane glycoprotein with a peculiar discontinuous pattern of expression in leukocytes, although evidence is accumulating of its quite widespread expression outside of the hematopoietic system...
  9. Adebanjo O, Anandatheerthavarada H, Koval A, Moonga B, Biswas G, Sun L, et al. A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis. Nat Cell Biol. 1999;1:409-14 pubmed
    ..Here we report the existence in the inner nuclear membrane of a functionally active CD38/ADP-ribosyl cyclase that has its catalytic site within the nucleoplasm...

More Information

Publications91

  1. Savarino A, Bottarel F, Calosso L, Feito M, Bensi T, Bragardo M, et al. Effects of the human CD38 glycoprotein on the early stages of the HIV-1 replication cycle. FASEB J. 1999;13:2265-76 pubmed
    b>CD38 displays lateral association with the HIV-1 receptor CD4. This association is potentiated by the HIV-1 envelope glycoprotein gp120. The aim of this work was to evaluate the CD38 role in T cell susceptibility to HIV-1 infection...
  2. Banerjee S, Walseth T, Borgmann K, Wu L, Bidasee K, Kannan M, et al. CD38/cyclic ADP-ribose regulates astrocyte calcium signaling: implications for neuroinflammation and HIV-1-associated dementia. J Neuroimmune Pharmacol. 2008;3:154-64 pubmed publisher
    b>CD38 is a 45-kD ectoenzyme involved in the synthesis of potent calcium (Ca(2+))-mobilizing agents, cyclic adenosine diphosphate-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP+)...
  3. Brachtl G, Sahakyan K, Denk U, Girbl T, Alinger B, Hofbauer S, et al. Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells. PLoS ONE. 2011;6:e23758 pubmed publisher
    VLA-4 and CD38 predict a poor clinical outcome in chronic lymphocytic leukemia (CLL)...
  4. Deaglio S, Vaisitti T, Bergui L, Bonello L, Horenstein A, Tamagnone L, et al. CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival. Blood. 2005;105:3042-50 pubmed
    This work addresses the question whether CD38, a negative prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL), plays a role in neoplastic B-cell growth and survival...
  5. Frasca L, Fedele G, Deaglio S, Capuano C, Palazzo R, Vaisitti T, et al. CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cells. Blood. 2006;107:2392-9 pubmed
    b>CD38, an ectoenzyme and a signaling receptor, is a novel marker of human mature monocyte-derived dendritic cells (MDDCs)...
  6. Lamkin T, Chin V, Varvayanis S, Smith J, Sramkoski R, Jacobberger J, et al. Retinoic acid-induced CD38 expression in HL-60 myeloblastic leukemia cells regulates cell differentiation or viability depending on expression levels. J Cell Biochem. 2006;97:1328-38 pubmed
    Retinoic acid-induced expression of the CD38 ectoenzyme receptor in HL-60 human myeloblastic leukemia cells is regulated by RARalpha and RXR, and enhanced or prevented cell differentiation depending on the level of expression per cell...
  7. Malavasi F, Deaglio S, Damle R, Cutrona G, Ferrarini M, Chiorazzi N. CD38 and chronic lymphocytic leukemia: a decade later. Blood. 2011;118:3470-8 pubmed publisher
    This review highlights a decade of investigations into the role of CD38 in CLL. CD38 is accepted as a dependable marker of unfavorable prognosis and as an indicator of activation and proliferation of cells when tested...
  8. Willimott S, Baou M, Huf S, Deaglio S, Wagner S. Regulation of CD38 in proliferating chronic lymphocytic leukemia cells stimulated with CD154 and interleukin-4. Haematologica. 2007;92:1359-66 pubmed
    ..The surface marker CD38 has roles in cell adhesion and signaling...
  9. Kang B, Tirumurugaan K, Deshpande D, Amrani Y, Panettieri R, Walseth T, et al. Transcriptional regulation of CD38 expression by tumor necrosis factor-alpha in human airway smooth muscle cells: role of NF-kappaB and sensitivity to glucocorticoids. FASEB J. 2006;20:1000-2 pubmed
    The transmembrane glycoprotein CD38 catalyzes the synthesis of the calcium mobilizing molecule cyclic ADP-ribose from NAD...
  10. Aydin S, Grabellus F, Eisele L, Möllmann M, Hanoun M, Ebeling P, et al. Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft model. Eur J Haematol. 2011;87:10-9 pubmed publisher
    We explored the role of CD38 and functionally associated molecular risk factors in a recently described chronic lymphocytic leukemia (CLL) nonobese diabetic/ severe combined immunodeficient xenograft model...
  11. Deaglio S, Aydin S, Grand M, Vaisitti T, Bergui L, D Arena G, et al. CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells. Mol Med. 2010;16:87-91 pubmed publisher
    Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsubstrate ligand CD31...
  12. Tirumurugaan K, Jude J, Kang B, Panettieri R, Walseth T, Kannan M. TNF-alpha induced CD38 expression in human airway smooth muscle cells: role of MAP kinases and transcription factors NF-kappaB and AP-1. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1385-95 pubmed
    In human airway smooth muscle (HASM) cells, the expression of CD38, which synthesizes the calcium-mobilizing molecule cyclic ADP-ribose, is augmented by TNF-alpha, a cytokine implicated in asthma...
  13. Jin D, Liu H, Hirai H, Torashima T, Nagai T, Lopatina O, et al. CD38 is critical for social behaviour by regulating oxytocin secretion. Nature. 2007;446:41-5 pubmed
    b>CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the formation of Ca2+ signalling molecules, but its role in the neuroendocrine system is unknown...
  14. Jude J, Dileepan M, Subramanian S, Solway J, Panettieri R, Walseth T, et al. miR-140-3p regulation of TNF-?-induced CD38 expression in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2012;303:L460-8 pubmed publisher
    b>CD38, a membrane protein expressed in airway smooth muscle (ASM) cells, plays a role in cellular Ca(2+) dynamics and ASM contractility...
  15. Jackson D, Bell J. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. J Immunol. 1990;144:2811-5 pubmed
    A cDNA clone encoding the human lymphocyte differentiation Ag CD38 was isolated from a mixture of four different lymphocyte CDNA libraries expressed transiently in COS cells and screened by panning with mAb...
  16. Deaglio S, Capobianco A, Bergui L, Dürig J, Morabito F, Duhrsen U, et al. CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells. Blood. 2003;102:2146-55 pubmed
    ..for patients with B-cell chronic lymphocytic leukemia (B-CLL) is generally less favorable for those expressing CD38. Our working hypothesis is that CD38 is not merely a marker in B-CLL, but that it plays a receptor role with ..
  17. Lande R, Urbani F, Di Carlo B, Sconocchia G, Deaglio S, Funaro A, et al. CD38 ligation plays a direct role in the induction of IL-1beta, IL-6, and IL-10 secretion in resting human monocytes. Cell Immunol. 2002;220:30-8 pubmed
    b>CD38 signaling, either induced by ligation with specific agonistic monoclonal antibody (mAb) or after interaction with CD31, its cognate counter-receptor, is involved in release of IL-1beta, IL-6, and IL-10 cytokines in resting human ..
  18. Nata K, Takamura T, Karasawa T, Kumagai T, Hashioka W, Tohgo A, et al. Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing. Gene. 1997;186:285-92 pubmed
    ..1993a) Science 259, 370-373] and that CD38 has both ADP-ribosyl cyclase (ADRC) and cADPR hydrolase activities [Takasawa et al. (1993b) J. Biol. Chem...
  19. Jude J, Tirumurugaan K, Kang B, Panettieri R, Walseth T, Kannan M. Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases. Am J Respir Cell Mol Biol. 2012;47:427-35 pubmed publisher
    The ADP-ribosyl cyclase activity of CD38 generates cyclic ADP-ribose, a Ca(2+)-mobilizing agent. In human airway smooth muscle (HASM) cells, TNF-? mediates CD38 expression through mitogen-activated protein kinases and NF-?B and AP-1...
  20. Tirumurugaan K, Kang B, Panettieri R, Foster D, Walseth T, Kannan M. Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-alpha and dexamethasone. Respir Res. 2008;9:26 pubmed publisher
    b>CD38 is expressed in human airway smooth muscle (HASM) cells, regulates intracellular calcium, and its expression is augmented by tumor necrosis factor alpha (TNF-alpha)...
  21. Tonino S, Spijker R, Luijks D, van Oers M, Kater A. No convincing evidence for a role of CD31-CD38 interactions in the pathogenesis of chronic lymphocytic leukemia. Blood. 2008;112:840-3 pubmed publisher
    Although CD38, a marker of poor prognosis in chronic lymphocytic leukemia (CLL), is known primarily as an ecto-enzyme, it has also been ascribed a receptor function...
  22. Ferrero E, Malavasi F. Human CD38, a leukocyte receptor and ectoenzyme, is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide+-converting enzymes: extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and ap. J Immunol. 1997;159:3858-65 pubmed
    The human leukocyte Ag CD38 is a 45-kDa type II membrane glycoprotein that functions both as a transmembrane signaling receptor and as an ectoenzyme...
  23. Sadeghi L, Yekta R, Dehghan G. New mechanisms of phenytoin in calcium homeostasis: competitive inhibition of CD38 in hippocampal cells. Daru. 2018;26:191-198 pubmed publisher
    ..Molecular docking simulation was also implemented to investigate the possible interaction between phenytoin and CD38. Our results confirmed phenytoin competitively inhibits cyclase activity of CD38 (IC50 = 8...
  24. Lagergren K, Ek W, Levine D, Chow W, Bernstein L, Casson A, et al. Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett's Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium. PLoS ONE. 2015;10:e0138738 pubmed publisher
    ..pathway (the oxytocin receptor (OXTR), oxytocin protein (OXT), and cyclic ADP ribose hydrolase glycoprotein (CD38)), were analysed using a gene-based approach, versatile gene-based test association study (VEGAS)...
  25. Tsagarakis N, Argyrou A, Gortzolidis G, Kentrou N, Papadhimitriou S, Tzanetou K, et al. Report of an HIV and HHV-8 negative case of primary effusion lymphoma with idiopathic T4 lymphocytopenia. Int J Hematol. 2009;90:94-98 pubmed publisher
    ..Flow cytometry revealed a hyperdiploid and highly mitotic large B-cell population, CD30, EMA, CD66, CD38 and CD71 positive...
  26. Yeganeh A, Taylor C, Tworek L, Poole J, Zahradka P. Trans-10,cis-12 conjugated linoleic acid (CLA) interferes with lipid droplet accumulation during 3T3-L1 preadipocyte differentiation. Int J Biochem Cell Biol. 2016;76:39-50 pubmed publisher
    ..These data are supported by evidence that t10-c12CLA activated PKC?. These are the first data to show that CLA isomers can affect lipid droplet dynamics in adipocytes through PKC?. ..
  27. May Z, Fenrich K, Dahlby J, Batty N, Torres Espín A, Fouad K. Following Spinal Cord Injury Transected Reticulospinal Tract Axons Develop New Collateral Inputs to Spinal Interneurons in Parallel with Locomotor Recovery. Neural Plast. 2017;2017:1932875 pubmed publisher
    ..In conclusion, our findings support the hypothesis that the injured RtST forms new connections and is a key player in the recovery of locomotion post-SCI...
  28. Shi H, Zhang T, Li C, Wang J, Huang J, Li Z. trans-10,cis-12-Conjugated Linoleic Acid Affects Expression of Lipogenic Genes in Mammary Glands of Lactating Dairy Goats. J Agric Food Chem. 2017;65:9460-9467 pubmed publisher
    ..05) and an increase of the SCD gene because of CLA supplementation (p < 0.05). In conclusion, t10,c12-CLA-induced MFD was possibly the result from the downregulation of genes involved in lipogenesis in goat mammary glands...
  29. Brachtl G, Piñón Hofbauer J, Greil R, Hartmann T. The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia. Ann Hematol. 2014;93:361-74 pubmed publisher
    ..b>CD38 and CD49d are both independent prognostic risk parameters in CLL with important roles in shaping these interactions...
  30. Wang Z, Liao L. Improvement in detrusor-sphincter dyssynergia by bladder-wall injection of replication-defective herpes simplex virus vector-mediated gene delivery of kynurenine aminotransferase II in spinal cord injury rats. Spinal Cord. 2017;55:155-161 pubmed publisher
    ..HSVrd vector encoding the KATII gene effectively improved DSD and detrusor overactivity by bladder-wall injection, perhaps by blocking N-methyl-d-aspartate receptors in the L6-S1 dorsal root ganglion and L6-S1 spinal cord. ..
  31. Kamel A, El Sharkawy N, Osman R, Abd El Fattah E, El Noshokaty E, Abd El Hamid T, et al. Adhesion molecules expression in CLL: Potential impact on clinical and hematological parameters. J Egypt Natl Canc Inst. 2016;28:31-7 pubmed publisher
    ..Adhesion molecules (CD11a, CD11b, CD49d, CD49C, CD29 and CD38) were tested using monoclonal antibodies and analyzed by Flow Cytometry...
  32. Chang G, Yang R, Cao Y, Nie A, Gu X, Zhang H. SIDT2 is involved in the NAADP-mediated release of calcium from insulin secretory granules. J Mol Endocrinol. 2016;56:249-59 pubmed publisher
    ..Finally, glucose-induced CD38 expression increased to a comparable level between Sidt2(-/-) and WT islets, suggesting that Sidt2(-/-) islets ..
  33. Singh A, Okonkwo L, Hoffmann J, Mazzie J, Baadh A. Nonamyloid tumoral light-chain-deposition disease (aggregoma) of the paraspinal region. Skeletal Radiol. 2015;44:1839-43 pubmed publisher
    ..The observation of our case adds to the limited understanding of the etiology, pathogenesis, natural history, and treatment of nonamyloid light-chain depositions. ..
  34. Lips M, van Klinken J, Pijl H, Janssen I, Willems van Dijk K, Koning F, et al. Weight loss induced by very low calorie diet is associated with a more beneficial systemic inflammatory profile than by Roux-en-Y gastric bypass. Metabolism. 2016;65:1614-1620 pubmed publisher
    ..The number of activated peripheral cytotoxic T (CD8+CD25+) and B (CD19+CD38+) cells was significantly higher after RYGB than after VLCD...
  35. Fueldner C, Mittag A, Knauer J, Biskop M, Hepp P, Scholz R, et al. Identification and evaluation of novel synovial tissue biomarkers in rheumatoid arthritis by laser scanning cytometry. Arthritis Res Ther. 2012;14:R8 pubmed publisher
    ..Therefore, we tested several monoclonal antibodies (mAbs) directed against cellular-surface molecules on cells likely to be involved in the pathogenesis of RA...
  36. Yang X, Tang Y, Wei Q, Lang B, Tao H, Zhang X, et al. Up-regulated expression of oxytocin mRNA in peripheral blood lymphocytes from first-episode schizophrenia patients. Oncotarget. 2017;8:78882-78889 pubmed publisher
    ..The peripheral mRNA expression of OXT, OXT receptor (OXTR), AVP, AVP 1a receptor (AVPR1a) and CD38 was determined by real-time quantitative polymerase chain reaction (RT-qPCR)...
  37. Ohta Y, Kitanaka A, Mihara K, Imataki O, Ohnishi H, Tanaka T, et al. Expression of CD38 with intracellular enzymatic activity: a possible explanation for the insulin release induced by intracellular cADPR. Mol Cell Biochem. 2011;352:293-9 pubmed publisher
    b>CD38 is a transmembrane glycoprotein expressed in multiple cell types, including pancreatic β cells...
  38. Obeid I, Vital J, Aurouer N, Hansen S, Gangnet N, Pointillart V, et al. Intraspinal canal rod migration causing late-onset paraparesis 8 years after scoliosis surgery. Eur Spine J. 2016;25:2097-101 pubmed publisher
    ..The very low virulence of the strain of Propionibacterium acnes is probably involved in this particular presentation where the rod was trapped in the canal, owing to the quite extensive laminar reconstitution. ..
  39. Chen W, Chen C, Chen N, Sung C, Wen Z. Neuroprotective Effects of Direct Intrathecal Administration of Granulocyte Colony-Stimulating Factor in Rats with Spinal Cord Injury. CNS Neurosci Ther. 2015;21:698-707 pubmed publisher
    ..Furthermore, rats with G-CSF treatment showed increased neurofilament expression beyond the glial scars. Direct i.t. administration of G-CSF provides a promising therapeutic option for SCI or related spinal diseases. ..
  40. Nicoli F, Chachage M, Clowes P, Bauer A, Kowour D, Ensoli B, et al. Association between different anti-Tat antibody isotypes and HIV disease progression: data from an African cohort. BMC Infect Dis. 2016;16:344 pubmed publisher
    ..01) and accumulation of CD38(+)HLADR(+)CD8(+) T cells (p- value?=?0.029)...
  41. Trabelsi H, Dendana F, Neji S, Sellami H, Cheikhrouhou F, Makni F, et al. Morphological and molecular identification of free living amoeba isolated from hospital water in Tunisia. Parasitol Res. 2016;115:431-5 pubmed publisher
    ..Thus, increased awareness regarding these parasites and recognition of their importance, particularly in immunocompromised patients is crucial. ..
  42. Kamphorst A, Pillai R, Yang S, Nasti T, Akondy R, Wieland A, et al. Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients. Proc Natl Acad Sci U S A. 2017;114:4993-4998 pubmed publisher
    ..These proliferating CD8 T cells had an effector-like phenotype (HLA-DR+, CD38+, Bcl-2lo), expressed costimulatory molecules (CD28, CD27, ICOS), and had high levels of PD-1 ..
  43. Ribatti D. The discovery of plasma cells: An historical note. Immunol Lett. 2017;188:64-67 pubmed publisher
    ..Plasma cells are characterized by the co-expression of CD138 and CD38, which allows their identification in flow cytometry in bone marrow, peripheral blood, or cell suspensions from ..
  44. Mikkilineni L, Kochenderfer J. Chimeric Antigen Receptor T-cell Therapies for Multiple Myeloma. Blood. 2017;: pubmed publisher
    ..MM antigens including CD138, CD38, signaling lymphocyte-activating molecule 7 (SLAMF7), and kappa light chain are under investigation as CAR targets...
  45. Bride K, Vincent T, Im S, Aplenc R, Barrett D, Carroll W, et al. Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia (T-ALL). Blood. 2018;: pubmed publisher
    ..We hypothesize targeting CD38 will be effective against T-ALL...
  46. Zhang M, Zhang L, Li H, Chen Z, Luo A, Liu B, et al. Circulating T follicular helper cells are associated with rapid virological response in chronic hepatitis C patients undergoing peginterferon therapy. Int Immunopharmacol. 2016;34:235-243 pubmed publisher
    ..There were no significant differences in CD19(+) B cells, CD19(+)CD27(+) B cells, or CD19(+)CD38(+) B cells between CHC patients and HCs...
  47. Zhang H, Graeff R, Chen Z, Zhang L, Zhang L, LEE H, et al. Dynamic conformations of the CD38-mediated NAD cyclization captured in a single crystal. J Mol Biol. 2011;405:1070-8 pubmed publisher
    The extracellular domain of human CD38 is a multifunctional enzyme involved in the metabolism of two Ca(2+) messengers: cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate...
  48. Mizuno S, Sonoda S, Takeda K, Maeshima S. Measurement of Resistive Plantar Flexion Torque of the Ankle during Passive Stretch in Healthy Subjects and Patients with Poststroke Hemiplegia. J Stroke Cerebrovasc Dis. 2016;25:946-53 pubmed publisher
    ..The patients showed increased velocity-dependent torque during fast stretches. Excellent reliability was observed. The device is suitable for measuring resistive PF torque during passive stretch in a flexed knee condition. ..
  49. Jain N, Lamanna N. Incorporating prognostic information into treatment decisions in chronic lymphocytic leukemia. Curr Oncol Rep. 2009;11:353-9 pubmed
    ..relevant markers: cytogenetic aberrations, zeta-associated protein 70, immunoglobulin mutational status, and CD38 expression...
  50. Sasamori K, Sasaki T, Takasawa S, Tamada T, Nara M, Irokawa T, et al. Cyclic ADP-ribose, a putative Ca2+-mobilizing second messenger, operates in submucosal gland acinar cells. Am J Physiol Lung Cell Mol Physiol. 2004;287:L69-78 pubmed
    ..technique, the measurement of microsomal Ca(2+) release, quantification of cellular cADPR, and RT-PCR for CD38 mRNA in human and feline tracheal glands...
  51. Holzapfel K, Schubert E, Huber Wagner S, Neu J. [Omitted spinal X-ray examination after a fall from a height of 3 m]. Unfallchirurg. 2016;119:159-63 pubmed publisher
    ..Although no irreversible damage to health resulted an earlier targeted treatment could have reduced the overall length of therapy. ..
  52. Chang C, Liu C, Cleveland R. Relative importance of CD38 expression over myeloid-associated markers expression in predicting the clinical course of B-CLL patients. Leuk Lymphoma. 2003;44:977-82 pubmed
    Expression of CD38 or myeloid-associated markers has been reported to be important in predicting prognosis in B-cell chronic lymphocytic leukemia (B-CLL) in separate studies but the impact of combining these markers on prognosis has not ..
  53. van Sanden S, Ito T, Diels J, Vogel M, Belch A, Oriol A. Comparative Efficacy of Daratumumab Monotherapy and Pomalidomide Plus Low-Dose Dexamethasone in the Treatment of Multiple Myeloma: A Matching Adjusted Indirect Comparison. Oncologist. 2018;23:279-287 pubmed publisher
    Daratumumab (a human CD38-directed monoclonal antibody) and pomalidomide (an immunomodulatory drug) plus dexamethasone are both relatively new treatment options for patients with heavily pretreated multiple myeloma...
  54. Blair H. Daratumumab: A Review in Relapsed and/or Refractory Multiple Myeloma. Drugs. 2017;77:2013-2024 pubmed publisher
    Intravenous daratumumab (DARZALEX®) is a first-in-class human IgG1? monoclonal antibody against CD38 available for use in patients with relapsed and/or refractory multiple myeloma...
  55. Ishioka Takei E, Yoshimoto K, Suzuki K, Nishikawa A, Yasuoka H, Yamaoka K, et al. Increased proportion of a CD38highIgD+ B cell subset in peripheral blood is associated with clinical and immunological features in patients with primary Sjögren's syndrome. Clin Immunol. 2018;187:85-91 pubmed publisher
    ..FACS analysis revealed that the proportions of peripherally CD38highIgD+ B cells and CD38highIgD- B cells were significantly increased ..
  56. Ishizaki A, Bi X, Nguyen L, Matsuda K, Pham H, Phan C, et al. Effects of Short-Term Probiotic Ingestion on Immune Profiles and Microbial Translocation among HIV-1-Infected Vietnamese Children. Int J Mol Sci. 2017;18: pubmed publisher
    ..regulatory T-cell (CD25highCD4?) counts decreased in the ART(+) and HIV(-) groups; activated CD8? cells (CD38?HLA-DR?CD8?) decreased from 27.5% to 13.2% (p < 0...
  57. Kikushige Y, Miyamoto T, Akashi K. Progress in the leukemic stem cell study and a novel therapeutic approach targeting leukemic stem cells. Rinsho Ketsueki. 2017;58:1838-1843 pubmed publisher
    ..Human HSCs reside within the CD34+CD38- cell fractions...
  58. Kiasari A, Babaei A, Alipour A, Motevalli S, Baradari A. Comparison of Hemodynamic Changes in Unilateral Spinal Anesthesia Versus Epidural Anesthesia Below the T10 Sensory Level in Unilateral Surgeries: a Double-Blind Randomized Clinical Trial. Med Arch. 2017;71:274-279 pubmed publisher
    ..The aim of the present study was to compare hemodynamic changes and complications in unilateral spinal anesthesia and epidural anesthesia below the T10 sensory level in unilateral surgeries...
  59. Fein P, DelMonaco A, Jackman T, Curtiss C, Guermazi A, Barest G, et al. Is bone density associated with intervertebral disc pressure in healthy and degenerated discs?. J Biomech. 2017;64:41-48 pubmed publisher
  60. Sauer C, Montag C, Wörner C, Kirsch P, Reuter M. Effects of a common variant in the CD38 gene on social processing in an oxytocin challenge study: possible links to autism. Neuropsychopharmacology. 2012;37:1474-82 pubmed publisher
    ..One potential candidate could be the CD38 gene, which codes for a transmembrane protein engaged in OT secretion processes...
  61. Matsushita M, Ozawa K, Suzuki T, Nakamura M, Nakano N, Kanchi S, et al. CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients. Blood Cancer J. 2017;7:e601 pubmed publisher
    ..Cytotoxic T cells (CTLs) induced by the epitope peptide derived from CXorf48 recognized CD34+CD38- cells obtained from the bone marrow of CML patients...
  62. Dolinska M, Piccini A, Wong W, Gelali E, Johansson A, Klang J, et al. Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34+CD38- stem and progenitor cells in chronic myeloid leukemia. Biochem Biophys Res Commun. 2017;490:378-384 pubmed publisher
    ..the expression of the mediators of the leukotriene pathway in bone marrow (BM) BCR-ABL+CD34+CD38- cells at diagnosis, and found low or undetectable expression of ALOX5...
  63. Poret N, Fu Q, Guihard S, Cheok M, Miller K, Zeng G, et al. CD38 in Hairy Cell Leukemia Is a Marker of Poor Prognosis and a New Target for Therapy. Cancer Res. 2015;75:3902-11 pubmed publisher
    ..One such protein was identified as CD38. Analysis of 51 HCL patients demonstrated that 18 were CD38-positive...
  64. Gazeau P, Alegria G, Devauchelle Pensec V, Jamin C, Lemerle J, Bendaoud B, et al. Memory B Cells and Response to Abatacept in Rheumatoid Arthritis. Clin Rev Allergy Immunol. 2017;53:166-176 pubmed publisher
    ..Next, we further explored the effects of abatacept on B cell subsets (IgD/CD38 in panel 1 and IgD/CD27 in panel 2) and observed that the basal level of CD38+ and/or CD27+ ..
  65. Stanfield B, Pahar B, Chouljenko V, Veazey R, Kousoulas K. Vaccination of rhesus macaques with the live-attenuated HSV-1 vaccine VC2 stimulates the proliferation of mucosal T cells and germinal center responses resulting in sustained production of highly neutralizing antibodies. Vaccine. 2017;35:536-543 pubmed publisher
    ..lymph nodes showed that VC2 vaccination stimulated significant increases in plasmablast (CD27highCD38high) and mature memory (CD21-IgM-) B cells...
  66. Liu X, Grogan T, Hieronymus H, Hashimoto T, Mottahedeh J, Cheng D, et al. Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome. Cell Rep. 2016;17:2596-2606 pubmed publisher
    ..Here, we demonstrate that low expression of CD38 identifies a progenitor-like subset of luminal cells in the human prostate...
  67. Zahran A, Elsayh K, Saad K, Embaby M, Ali A. Regulatory B cells (CD19(+)CD38(hi)CD24(hi)) in alloimmunized and non-alloimmunized children with β-thalassemia major. Blood Cells Mol Dis. 2016;57:91-6 pubmed publisher
    ..We investigated the frequency of B-regulatory cells (CD19(+)CD38(hi)CD24(hi)); (Bregs) among polytransfused alloimmunized and non-alloimmunized children with BTM...
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    ..However, coculture of normal PBMCs with Env-expressing cells resulted in selective CD4 loss that was significantly enhanced by IA. Our study demonstrates that AIP of HIV-1 Env and IA collectively determine CD4 loss in HIV infection. ..
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    Deficits in social behavior in mice lacking the CD38 gene have been attributed to impaired secretion of oxytocin...
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    b>CD38 rules proliferation signals in chronic lymphocytic leukemia (CLL) cells, suggesting that the molecule is not merely a prognostic marker but also a key element in the pathogenetic network underlying the disease...
  71. Zhou L, Zhang X, Zhou P, Li X, Xu X, Shi Q, et al. Effect of testosterone and hypoxia on the expansion of umbilical cord blood CD34+ cells in vitro. Exp Ther Med. 2017;14:4467-4475 pubmed publisher
    ..addition of testosterone under hypoxia promoted the differentiation of CD34+ cells into CD34+CD38+CD71+ erythroid progenitor cells...
  72. Zhao Y, Lam C, Lee H. The membrane-bound enzyme CD38 exists in two opposing orientations. Sci Signal. 2012;5:ra67 pubmed publisher
    The transmembrane enzyme CD38, a multifunctional protein ubiquitously present in cells, is the main enzyme that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose (cADPR), an intracellular Ca(2+)-mobilizing messenger...
  73. Berhe K, Weldeselassie G, Bettridge J, Christley R, Abdi R. Small ruminant pasteurellosis in Tigray region, Ethiopia: marked serotype diversity may affect vaccine efficacy. Epidemiol Infect. 2017;145:1326-1338 pubmed publisher
    ..Diverse serotypes were circulating in the Tigray region and could be a challenge in selecting serotypes for vaccine...
  74. Liu J, Gong P, Li H, Zhou X. A field study of the association between CD38 gene and altruistic behavior: Empathic response as a mediator. Psychoneuroendocrinology. 2017;85:165-171 pubmed publisher
    ..we conducted a field study with a real fundraising event and investigated to what extent oxytocin pathway genes (CD38 and OXTR) modulate individual differences in charitable donation...
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    ..Spinal column shortening for adult TCS can be safely achieved through a mini-open approach. Future studies should compare the efficacy of this technique to both traditional de-tethering and open spinal column shortening. ..
  76. Li X, Wu F, Zhao F, Huang S. Fractional anisotropy is a marker in early-stage spinal cord injury. Brain Res. 2017;1672:44-49 pubmed publisher
    ..FA significantly related with the serum testing results at 24h. FA may be used as a marker for different severities of SCI. The optimal time for examination is at 24h post-injury in rat. ..
  77. Cruse J, Lewis R, Webb R, Sanders C, Suggs J. Zap-70 and CD38 as predictors of IgVH mutation in CLL. Exp Mol Pathol. 2007;83:459-61 pubmed
    Zeta-chain (TCR)-associated protein kinase 70 kDa (Zap-70) and CD38 expression may be of prognostic significance in chronic lymphocytic leukemia (CLL)...
  78. Young E, Noerenberg D, Mansouri L, Ljungström V, Frick M, Sutton L, et al. EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia. Leukemia. 2017;31:1547-1554 pubmed publisher
    ..8%) investigated cases, and associated with younger age at diagnosis, advanced clinical stage, high CD38 expression and unmutated IGHV genes...
  79. Vinnard C, Ravimohan S, Tamuhla N, Pasipanodya J, Srivastava S, Modongo C, et al. Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation. PLoS ONE. 2017;12:e0187624 pubmed publisher
    ..Pyrazinamide clearance was higher in men than women. Expression of CD38 and HLA- DR on CD8+T cells, a measure of HIV-associated immune activation, was inversely related to pyrazinamide ..
  80. Watt J, Graeff R, Thomas M, Potter B. Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose". Sci Rep. 2017;7:16100 pubmed publisher
    The multifunctional, transmembrane glycoprotein human CD38 catalyses the synthesis of three key Ca2+-mobilising messengers, including cyclic adenosine 5'-diphosphate ribose (cADPR), and CD38 knockout studies have revealed the ..
  81. Yang Y, Sauve A. NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy. Biochim Biophys Acta. 2016;1864:1787-1800 pubmed publisher
    ..within NAD+ metabolism trigger major signaling processes coupled to effectors (sirtuins, PARPs, and CD38) that reprogram cellular metabolism using NAD+ as an effector substrate...
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