CD34

Summary

Gene Symbol: CD34
Description: CD34 molecule
Alias: hematopoietic progenitor cell antigen CD34, CD34 antigen
Species: human
Products:     CD34

Top Publications

  1. Fina L, Molgaard H, Robertson D, Bradley N, Monaghan P, Delia D, et al. Expression of the CD34 gene in vascular endothelial cells. Blood. 1990;75:2417-26 pubmed
    ..In addition, CD34 antigen cannot be upregulated by growth factors...
  2. Olthof S, Fatrai S, Drayer A, Tyl M, Vellenga E, Schuringa J. Downregulation of signal transducer and activator of transcription 5 (STAT5) in CD34+ cells promotes megakaryocytic development, whereas activation of STAT5 drives erythropoiesis. Stem Cells. 2008;26:1732-42 pubmed publisher
    ..as the megakaryocytic marker CD41, to optimize progenitor sorting procedures to further subfractionate the MEP (CD34(+)CD110(+)CD45RA(-)) into erythroid progenitors (CD34(+)CD110(+)CD45RA(-)CD41(-)) and megakaryocytic progenitors (..
  3. Qi Y, Qian L, Sun B, Chen C, Cao Y. Circulating CD34(+) cells are elevated in neonates with respiratory distress syndrome. Inflamm Res. 2010;59:889-95 pubmed publisher
    ..Circulating CD34(+) cells were identified by flow cytometry in 41 RDS in comparison with 20 preterm and 14 term controls without ..
  4. Sahoo S, Klychko E, Thorne T, Misener S, Schultz K, Millay M, et al. Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activity. Circ Res. 2011;109:724-8 pubmed publisher
    Transplantation of human CD34(+) stem cells to ischemic tissues has been associated with reduced angina, improved exercise time, and reduced amputation rates in phase 2 clinical trials and has been shown to induce neovascularization in ..
  5. Levantini E, Lee S, Radomska H, Hetherington C, Alberich Jorda M, Amabile G, et al. RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element. EMBO J. 2011;30:4059-70 pubmed publisher
    ..Here, we obtained novel insights into RUNX1 function by studying regulation of the human CD34 gene, which is expressed in HSCs...
  6. Siemerink M, Klaassen I, Vogels I, Griffioen A, Van Noorden C, Schlingemann R. CD34 marks angiogenic tip cells in human vascular endothelial cell cultures. Angiogenesis. 2012;15:151-63 pubmed publisher
    ..We previously showed that the sialomucin CD34 is expressed in a small subset of cultured endothelial cells and that these cells extend filopodia: a hallmark of ..
  7. Lee J, Lee S, Yoo S, Asahara T, Kwon S. CD34 hybrid cells promote endothelial colony-forming cell bioactivity and therapeutic potential for ischemic diseases. Arterioscler Thromb Vasc Biol. 2013;33:1622-34 pubmed publisher
    ..Although endothelial progenitor cells (EPCs) have been reported to promote neovessel formation during vascular injury, the function of supporting cells of EPCs and their interaction with EPCs during EPC isolation remain unclear...
  8. Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, et al. JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice. Gastroenterology. 2018;154:1480-1493 pubmed publisher
    ..induce a pH-dependent form cell death (alkaliptosis) in cancer cells but not normal cells (hepatocytes, bone marrow CD34+ progenitor cells, peripheral blood mononuclear cells, or dermal fibroblasts) or healthy tissues of ..
  9. Shen J, Cao S, Sun X, Pan B, Cao J, Che D, et al. Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line. Cell Physiol Biochem. 2018;51:2938-2954 pubmed publisher
    ..lung, and kidney of the mice, and immunohistochemistry was used to examine changes in the expression of tumor CD34 and receptor-interacting protein kinase-3 (RIP3), while terminal deoxynucleotidyl transferase-mediated dUTP nick-..

More Information

Publications147 found, 100 shown here

  1. Xiao H, Xiong L, Song X, Jin P, Chen L, Chen X, et al. Angelica sinensis Polysaccharides Ameliorate Stress-Induced Premature Senescence of Hematopoietic Cell via Protecting Bone Marrow Stromal Cells from Oxidative Injuries Caused by 5-Fluorouracil. Int J Mol Sci. 2017;18: pubmed publisher
    ..treated HS-5 feeder layer resulted in less quantity of human umbilical cord blood-derived hematopoietic cells and CD34? hematopoietic stem/progenitor cells (HSPCs), and SIPS of hematopoietic cells...
  2. Tang X, Luan Z, Wu N, Zhang B, Jing Y, Du H, et al. [Treatment of Gaucher disease with allogeneic hematopoietic stem cell transplantation: report of three cases and review of literatures]. Zhonghua Er Ke Za Zhi. 2015;53:810-6 pubmed
    ..9 × 10⁷ /kg and 7.6 × 10⁷/kg respectively. The dose of cord blood stem cell CD34⁺ cell counts was 5.4 × 10⁵/kg , 3.5 × 10⁵/kg and 3.2 × 10⁵/kg respectively...
  3. Xu Y, Dai G, Liu Q, Ma X, Li L, Chen W, et al. Effect of Ermiao Recipe with medicinal guide Angelicae Pubescentis Radix on promoting the homing of bone marrow stem cells to treat cartilage damage in osteoarthritis rats. Chin J Integr Med. 2014;20:600-9 pubmed publisher
    ..MMP)-13, tissue inhibitors of metalloproteinase (TIMP)-1, bromodeoxyuridine (BrdU), cluster of differentiation 34 (CD34), and stromal cell derived factor 1 (SDF-1) were measured by immunohistochemistry assay...
  4. Boska M, Dash P, Knibbe J, Epstein A, Akhter S, Fields N, et al. Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice. Mol Neurodegener. 2014;9:58 pubmed publisher
    ..Chronic HIV-1 infection of NOD/scid-IL-2Rgcnull mice transplanted with human CD34+ hematopoietic stem cells (CD34-NSG) leads to persistent viremia, profound CD4+ T lymphocyte loss and infection of ..
  5. Jiang Y, Wang H, Zhuang W, Chen H, Zhang C, Li X, et al. [Clinical and Pathologic Features of Myeloid Sarcoma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:926-931 pubmed publisher
    ..The neoplasms were positive for MPO, CD34, CD43, CD45, CD99 and CD117 by immunohistochemical staining...
  6. Wang R, Lin M, Li L, Li L, Qi G, Rong R, et al. [Bone marrow mesenchymal stem cell-derived exosome protects kidney against ischemia reperfusion injury in rats]. Zhonghua Yi Xue Za Zhi. 2014;94:3298-303 pubmed
    ..Dectection of surface markers revealed high expression levels of CD29 and CD44 and a low expression level of CD34. MSC differentiated successfully into osteoblasts and lipocytes after growing in osteoblast- and lipocyte-inducing ..
  7. Sherif R, Abdellatif H, Hazem N, Ebrahim N, Saleh D, Shiha G, et al. Effect of human umbilical cord blood derived CD34+ hematopoietic stem cell on the expression of Wnt4 and P53 genes in a rat model of hepatocellular carcinoma. Tissue Cell. 2018;50:125-132 pubmed publisher
    ..This research aimed to study the effectiveness of human CD34+ hematopoietic stem cell on Wnt4 and P53 genes expression, histopathological grading and hepatic progenitor cells ..
  8. Kim D, Lee S, Jeon J, Park H. Development of air-blast dried non-Saccharomyces yeast starter for improving quality of Korean persimmon wine and apple cider. Int J Food Microbiol. 2019;290:193-204 pubmed publisher
    ..anomalus (Synonym Pichia anomala) SJ20, Meyerozyma caribbica (Synonym Pichia caribbica) YP1, Pichia kluyveri CD34, Hanseniaspora uvarum SJ69 (for persimmon wine), W...
  9. Booka E, Kitano M, Nakano Y, Mihara K, Nishiya S, Nishiyama R, et al. Life-threatening giant esophageal neurofibroma with severe tracheal stenosis: a case report. Surg Case Rep. 2018;4:107 pubmed publisher
    ..Immunohistochemical staining was positive for S-100 but negative for c-KIT, CD34, ?-SMA, and desmin; these morphological and immunohistochemical characteristics were consistent with the diagnosis ..
  10. Xiong L, Jing P, Song X, Wang Y, Wang L. [5-FU-Injured Bone Marrow Stromal Cells Initiate Stress-induced Premature Senescence of Hematopoietic Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1178-1186 pubmed publisher
    ..staining after co-culture with HS-5, FCM was used to detect the cell cycle distribution, ROS level and the ratio of CD34+ cells...
  11. Zhang X, Zhu Y, Wang X, Miao J, Li H, Tong Z. [Bronchial glomus tumor: report of 2 cases and review of the literature]. Zhonghua Jie He He Hu Xi Za Zhi. 2014;37:758-63 pubmed
    ..Immunohistochemically, cytokeratin (CK) was negative, while vimentin and CD34 vascular endothelial cell were positive, smooth muscle actin (SMA) weakly positive, and Synaptophysin partially ..
  12. Musto P, Simeon V, Todoerti K, Neri A. Primary Plasma Cell Leukemia: Identity Card 2016. Curr Treat Options Oncol. 2016;17:19 pubmed publisher
    ..alkylating agents, in particular melphalan, should be initially avoided in order to allow adequate collections of CD34+ peripheral blood stem cells (PBSC)...
  13. Liu X, Zang P, Han F, Hou N, Sun X. Renal protective effects of induction of haem oxygenase-1 combined with increased adiponectin on the glomerular vascular endothelial growth factor-nitric oxide axis in obese rats. Exp Physiol. 2015;100:865-76 pubmed publisher
    ..Renal tissues were collected for CD34 immunohistochemistry...
  14. Ali M, Mehmood A, Anjum M, Tarrar M, Khan S, Riazuddin S. Diazoxide preconditioning of endothelial progenitor cells from streptozotocin-induced type 1 diabetic rats improves their ability to repair diabetic cardiomyopathy. Mol Cell Biochem. 2015;410:267-79 pubmed publisher
    ..and reverse transcriptase PCR for endothelial cell-specific markers like vWF, VE cadherin, VEGFR2, PECAM, CD34, and eNOS...
  15. Fernando R, Placzek E, Reese E, Placzek A, Schwartz S, Trierweiler A, et al. Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy. J Clin Endocrinol Metab. 2017;102:776-785 pubmed publisher
    The sources and biological impact of 3,3',5,5' tetraiodothyroacetic acid (TA4) are uncertain. CD34+ fibrocytes express several proteins involved in the production of thyroid hormones...
  16. Gutiérrez R, Díaz Flores L, Goméz M, Sáez F, Madrid J. Behaviour of telocytes during physiopathological activation. Semin Cell Dev Biol. 2016;55:50-61 pubmed publisher
    We consider CD34+ stromal cells/telocytes (CD34+ SC/TCs) in normal and pathological conditions...
  17. Ascione R, Rowlinson J, Avolio E, Katare R, Meloni M, Spencer H, et al. Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction. Stem Cell Res Ther. 2015;6:53 pubmed publisher
    ..In vitro migration enriched for monocytes, while CD34(+) and CD133(+) cells and T lymphocytes remained mainly confined in the non-migrated fraction...
  18. Wu Z, Yang H, Weng D, Ding Y. Rapid recurrence and bilateral lungs, multiple bone metastasis of malignant solitary fibrous tumor of the right occipital lobe: report of a case and review. Diagn Pathol. 2015;10:91 pubmed publisher
    ..Immunohistochemically, tumor cells were diffusely positive for vimentin and CD99, focal positive for CD34, bcl-2 and Actin. Ki-67 labelling index was more than 40%...
  19. Patel P, Senyuk V, Rodriguez N, Oh A, Bonetti E, Mahmud D, et al. Synergistic Cytotoxic Effect of Busulfan and the PARP Inhibitor Veliparib in Myeloproliferative Neoplasms. Biol Blood Marrow Transplant. 2019;: pubmed publisher
    ..02). Finally, we tested the combined effect of busulfan and veliparib on CD34+ cells obtained from the bone marrow or peripheral blood of 5 patients with JAK2V617F-mutated ..
  20. Jiang Z, Liu Y, Niu X, Yin J, Hu B, Guo S, et al. Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats. Stem Cell Res Ther. 2016;7:24 pubmed publisher
    ..cultured and were verified by positive markers for CD29, CD73, CD90 and CD44 antigens, and negative markers for CD34, CD45 and HLA-DR...
  21. Cioch M, Jawniak D, Kotwica K, Wach M, Mańko J, Gorący A, et al. Biosimilar granulocyte colony-stimulating factor is effective in reducing the duration of neutropenia after autologous peripheral blood stem cell transplantation. Transplant Proc. 2014;46:2882-4 pubmed publisher
    ..The median number of transplanted CD34+ cells was 4.2 ± 0.8 × 10(6)/kg body wt...
  22. Xu Y, Dai G, Liu Q, Zhu H, Chen W, Zhang P, et al. Effect of ermiao fang with xixin (herba asari mandshurici) on bone marrow stem cell directional homing to a focal zone in an osteoarthritis rat model. J Tradit Chin Med. 2014;34:477-87 pubmed
    ..tissue inhibitors of metalloproteinases (TIMPs)-1, Bromodeoxyuridine (BrdU), cluster of differentiation 34 (CD34), and stromal cell-derived factor 1 (SDF-1) were measured by immunohistochemical assay...
  23. Madaric J, Valachovicová M, Paulis L, Príbojová J, Mateova R, Sebekova K, et al. Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia. Stem Cell Res Ther. 2017;8:165 pubmed publisher
    ..03, r?=?-0.44) after cell delivery. ADMA or TNF-? improvement did not correlate with the number of applied CD34+ cells, C-reactive protein concentration, leukocyte count, or the dose of atorvastatin...
  24. Hao Z, Wu H, Li Y, Wang S, Lu J. [Comparison of biological characteristics between bone marrow mesenchymal stem cells and anterior cruciate ligament derived mesenchymal stem cells in rats]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017;31:473-480 pubmed publisher
    ..The cell morphology was observed, and the cells at passage 3 were used to detect the surface markers of CD34, CD45, CD90, and CD29 by flow cytometry, the ability of cell proliferation by cell counting kit 8 (CCK-8), and ..
  25. Shirai T, Tsuchida S, Terauchi R, Mizoshiri N, Konishi E, Tomita Y, et al. Primary pulmonary synovial sarcoma requiring differentiation from pulmonary metastasis of tibial adamantinoma: a case report. BMC Res Notes. 2014;7:736 pubmed publisher
    ..They were negative for CD34. The synovial sarcoma, X breakpoint 1 gene-fusion transcript was detected by reverse transcription-polymerase chain ..
  26. Hasky N, Uri Belapolsky S, Goldberg K, Miller I, Grossman H, Stemmer S, et al. Gonadotrophin-releasing hormone agonists for fertility preservation: unraveling the enigma?. Hum Reprod. 2015;30:1089-101 pubmed publisher
    ..Vascular endothelial growth factor (VEGF) was measured by quantitative PCR. Ovarian GnRH receptor (GnRHR), AMH and CD34 were visualized by IHC, and apoptosis was evaluated using TdT (terminal deoxynucleotidyl transferase)-mediated dUDP ..
  27. Li Y, Wang H, Sun T, Chen J, Guo L, Shen H, et al. Biological characteristics of a new human glioma cell line transformed into A2B5(+) stem cells. Mol Cancer. 2015;14:75 pubmed publisher
    ..staining revealed murine vessels at the border between xenograft tumor and normal brain tissue; Anti-human CD34 (Cluster of differentiation34) staining was negative...
  28. Li Q, Li B, Luo C, Wang J, Luo C, Ding L, et al. [Molecular diagnosis and hematopoietic stem cell transplantation in 17 children with inherited bone marrow failure syndrome]. Zhonghua Er Ke Za Zhi. 2015;53:817-23 pubmed
    ..Median age at the time of HSCT was 36 months (7-156 months). The number of infused mononuclear cells and CD34⁺ cells was (10.6 ± 6.7) × 10⁸ and (5.9 ± 7...
  29. Zou Y, Guo C, Zhang M. Inhibition of human hepatocellular carcinoma tumor angiogenesis by siRNA silencing of VEGF via hepatic artery perfusion. Eur Rev Med Pharmacol Sci. 2015;19:4751-61 pubmed
    ..Intratumoral microvessel density (MVD), VEGF and CD34 were evaluated by immunohistochemistry. We detected the cell apoptotic by immunofluorescence and flow cytometry...
  30. Friedrich E, Walenta K, Scharlau J, Nickenig G, Werner N. CD34-/CD133+/VEGFR-2+ endothelial progenitor cell subpopulation with potent vasoregenerative capacities. Circ Res. 2006;98:e20-5 pubmed
    ..Fluorescence-activated cell sorter analysis of CD133+ progenitor cells revealed the presence of CD34+ and CD34- subpopulations...
  31. Li L, Tao J, Fu R, Wang H, Jiang H, Yue L, et al. Increased CD34+CD38 -CD123 + cells in myelodysplastic syndrome displaying malignant features similar to those in AML. Int J Hematol. 2014;100:60-9 pubmed publisher
    ..We previously found that CD123 was also highly expressed on CD34(+)CD38(-) cells in myelodysplastic syndrome (MDS) patients, but it is unclear whether the level and the ..
  32. Degen R, Carbone A, Carballo C, Zong J, Chen T, Lebaschi A, et al. The Effect of Purified Human Bone Marrow-Derived Mesenchymal Stem Cells on Rotator Cuff Tendon Healing in an Athymic Rat. Arthroscopy. 2016;32:2435-2443 pubmed publisher
    ..the stem cell phenotype of the cells as CD73+, CD90+, CD105+, CD14-, CD34-, and CD45-...
  33. Hoban M, Lumaquin D, Kuo C, Romero Z, Long J, Ho M, et al. CRISPR/Cas9-Mediated Correction of the Sickle Mutation in Human CD34+ cells. Mol Ther. 2016;24:1561-9 pubmed publisher
    ..Delivery of the CRISPR/Cas9 components to CD34+ cells led to over 18% gene modification in vitro...
  34. Boudreau J, Liu X, Zhao Z, Zhang A, Shultz L, Greiner D, et al. Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I. Immunity. 2016;45:280-91 pubmed publisher
    ..and in patients undergoing HLA-mismatched hematopoietic cell transplantation (HCT), NK cells derived from human CD34(+) stem cells were educated by HLA from both donor hematopoietic cells and host stromal cells...
  35. Kovilakath A, Mohamad S, Hermes F, Wang S, Ginder G, Lloyd J. In Vitro Erythroid Differentiation and Lentiviral Knockdown in Human CD34+ Cells from Umbilical Cord Blood. Methods Mol Biol. 2018;1698:259-274 pubmed publisher
    Human umbilical cord blood is a rich source of hematopoietic stem and progenitor cells. CD34+ cells in umbilical cord blood are more primitive than those in peripheral blood or bone marrow, and can proliferate at a high rate and ..
  36. Sudchada S, Kheolamai P, U Pratya Y, Chayosumrit M, Supokawej A, Manochantr S, et al. CD14-/CD34+ is the founding population of umbilical cord blood-derived endothelial progenitor cells and angiogenin1 is an important factor promoting the colony formation. Ann Hematol. 2012;91:321-9 pubmed publisher
    ..We further characterized the founding population of UCB-derived EPCs by separating CD14- subpopulation into CD14-/CD34+ and CD14-/CD34- subpopulations...
  37. Lam Y, Chan Y, Chan L, Ng R. Histone deacetylase inhibitors induce leukemia gene expression in cord blood hematopoietic stem cells expanded ex vivo. Int J Hematol. 2017;105:37-43 pubmed publisher
    ..Nevertheless, we observed 20-30-fold expansion of the CD34+ CD38- HSPC population...
  38. Duan Z, Deng J, Dong Y, Zhu C, Li W, Fan D. Anticancer effects of ginsenoside Rk3 on non-small cell lung cancer cells: in vitro and in vivo. Food Funct. 2017;8:3723-3736 pubmed publisher
    ..In addition, we confirmed that Rk3 inhibited angiogenesis via CD34 staining and chick embryo chorioallantoic membrane (CAM) assay in vivo...
  39. Gomez Limia C, Devalle S, Reis M, Sochacki J, Carneiro M, Madeiro da Costa R, et al. Generation and characterization of a human induced pluripotent stem (iPS) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the CALR 52bp deletion and the ASXL1 p.R693X mutation. Stem Cell Res. 2017;24:16-20 pubmed publisher
    ..1092_1143del, p.L367fs*46) and the R693X mutation in the ASXL1 gene (c.2077C>T, p.R693X). CD34+ cells were isolated from the sample and subjected to the reprogramming procedure by using the Sendai virus ..
  40. Liu C, Nie D, Li J, Du X, Lu Y, Li Y, et al. Antitumor Effects of Blocking Protein Neddylation in T315I-BCR-ABL Leukemia Cells and Leukemia Stem Cells. Cancer Res. 2018;78:1522-1536 pubmed publisher
    ..Moreover, MLN4924 inhibited the survival and self-renewal of primary human CML CD34+ cells and LSCs in CML-bearing mice via accumulation of p27kip1 in the nucleus...
  41. Zhang S, Matsumoto T, Uefuji A, Matsushita T, Takayama K, Araki D, et al. Anterior cruciate ligament remnant tissue harvested within 3-months after injury predicts higher healing potential. BMC Musculoskelet Disord. 2015;16:390 pubmed publisher
    ..isolated from remnant tissues and their healing potential was evaluated by: 1) characterization of surface markers (CD34, CD44, CD45, CD146, CD29, and Stro-1), 2) cell expansion, 3) osteogenic differentiation, and 4) endothelial ..
  42. Saruwatari K, Ikemura S, Sekihara K, Kuwata T, Fujii S, Umemura S, et al. Aggressive tumor microenvironment of solid predominant lung adenocarcinoma subtype harboring with epidermal growth factor receptor mutations. Lung Cancer. 2016;91:7-14 pubmed publisher
    ..and examined expression levels of EGFR, E-cadherin, ezrin, laminin-5, ALDH1, and PD-L1 in cancer cells, and of CD34, CD204, podoplanin (PDPN), and FoxP3 in stromal cells in 4 subtypes (n=20 each)...
  43. Jimenez S, Piera Velazquez S. Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality?. Matrix Biol. 2016;51:26-36 pubmed publisher
    ..SSc originate from several sources including expansion of quiescent tissue fibroblasts and tissue accumulation of CD34+ fibrocytes...
  44. Matsuoka Y, Takahashi M, Sumide K, Kawamura H, Nakatsuka R, Fujioka T, et al. CD34 Antigen and the MPL Receptor Expression Defines a Novel Class of Human Cord Blood-Derived Primitive Hematopoietic Stem Cells. Cell Transplant. 2017;26:1043-1058 pubmed publisher
    ..We have identified very primitive human cord blood (CB)-derived CD34- severe combined immunodeficiency (SCID)-repopulating cells (SRCs) using the intra-bone marrow injection method...
  45. Ebrahim E, Assem M, Amin A, Kamel M, El Meligui Y, Metwally A. FLT3 Internal Tandem Duplication Mutation, cMPL and CD34 Expressions Predict Low Survival in Acute Myeloid Leukemia Patients. Ann Clin Lab Sci. 2016;46:592-600 pubmed
    ..76.9% of adult and 89.5% of pediatric patients expressed CD33. 64.1 % of adults and 42.1% of children expressed CD34. CD34 expression was significantly associated with both FLT3 ITD mutation and cMPL expression...
  46. Chandravanshi B, Bhonde R. Reprogramming mouse embryo fibroblasts to functional islets without genetic manipulation. J Cell Physiol. 2018;233:1627-1637 pubmed publisher
    ..They were positive for CD markers-Sca1, CD44, CD73, and CD90 and negative for hematopoietic markers-CD34 and CD45 at both transcription and translational levels...
  47. Denollet J, van Felius R, Lodder P, Mommersteeg P, Goovaerts I, Possemiers N, et al. Predictive value of Type D personality for impaired endothelial function in patients with coronary artery disease. Int J Cardiol. 2018;259:205-210 pubmed publisher
    ..Flow-mediated dilation (FMD) of the brachial artery and circulating CD34+/KDR+/CD45+dim endothelial progenitor cells (EPCs) were assessed at ..
  48. Owatari S, Otsuka M, Takeshita T, Mizukami K, Suzuki S, Uozumi K, et al. Uncommon cases of immature-type CD56+ natural killer (NK)-cell neoplasms, characterized by expression of myeloid antigen of blastic NK-cell lymphoma. Int J Hematol. 2009;89:188-194 pubmed publisher
    ..Skin biopsy specimen revealed CD4(+), CD7(-), CD34(-), CD43(+), CD56(+), CD68(+), muramidase (lysozyme)(+), and myeloperoxidase (MPO)(-), and immunophenotyping of ..
  49. Raluca B, Cimpean A, Cioca A, Creţu O, Mederle O, Ciolofan A, et al. Endothelial Cell Proliferation and Vascular Endothelial Growth Factor Expression in Primary Colorectal Cancer and Corresponding Liver Metastases. Asian Pac J Cancer Prev. 2015;16:4549-53 pubmed
    ..Our study included 24 recent biopsies of primary tumors and corresponding liver metastases of CRC cases. CD34/ Ki67 double immunostaining and RNA scope assay for VEGF were performed...
  50. Xu H, Liu C, Gu M, Chen Y, Cai Z, Chen Q, et al. Prostatic vascular damage induced by cigarette smoking as a risk factor for recovery after holmium laser enucleation of the prostate (HoLEP). Oncotarget. 2017;8:14039-14049 pubmed publisher
    ..Pathologically, HE staining, CD31 and CD34 were analysed in prostatic section chips...
  51. Pievani A, Sacchetti B, Corsi A, Rambaldi B, Donsante S, Scagliotti V, et al. Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo. Development. 2017;144:1035-1044 pubmed publisher
    ..Furthermore, human CD34+ cells transplanted into ossicle-bearing mice engrafted and maintained human HSCs in the niche...
  52. Fukuda S, Fujiwara Y, Wakasa T, Inoue K, Kitani K, Ishikawa H, et al. Small, spontaneously ruptured gastrointestinal stromal tumor in the small intestine causing hemoperitoneum: A case report. Int J Surg Case Rep. 2017;36:64-68 pubmed publisher
    ..Immunohistochemical staining revealed that the tumor was positive for KIT and CD34; therefore, a final diagnosis of GIST was made...
  53. Sharma S, Sharma A, Lobo G, Nayak M, Pradhan D, Samriti -, et al. Primary dura-based synovial sarcoma of the parafalcine region of brain. Pathol Res Pract. 2017;213:868-871 pubmed publisher
    ..Pancytokeratin was focally positive. Epithelial membrane antigen, progesterone receptor, CD34, S-100, and glial fibrillary acidic protein were negative...
  54. Furey A, Rastogi S, Prince R, Jin Z, Smilow E, Briamonte C, et al. Bone Marrow Harvest in Pediatric Sibling Donors: Role of Granulocyte Colony-Stimulating Factor Priming and CD34+ Cell Dose. Biol Blood Marrow Transplant. 2018;24:324-329 pubmed publisher
    ..algorithm to optimize bone marrow harvest volume from pediatric matched sibling donors, and studied the impact of CD34+ cell dose on clinical outcomes...
  55. Green J, Endale M, Auer H, Perl A. Diversity of Interstitial Lung Fibroblasts Is Regulated by Platelet-Derived Growth Factor Receptor α Kinase Activity. Am J Respir Cell Mol Biol. 2016;54:532-45 pubmed publisher
    ..Although CD140α(+)CD29(+) cells behaved as myofibroblasts, CD140α(+)CD34(+) appeared as matrix and/or lipofibroblasts...
  56. Stockklausner C, Raffel S, Klermund J, Bandapalli O, Beier F, Brümmendorf T, et al. A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition. Aging (Albany NY). 2015;7:911-27 pubmed
    ..Thus, rapamycin treatment did not rescue the compromised stem cell function of TERTT1129P mutant patient HSCs and outlines limitations of a potential DKC therapy based on rapamycin. ..
  57. Moschoi R, Imbert V, Nebout M, Chiche J, Mary D, Prebet T, et al. Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy. Blood. 2016;128:253-64 pubmed publisher
    ..Transfer was greater in AML blasts compared with normal cord blood CD34(+) cells...
  58. Wang H, Li J. Clinicopathological features of myeloid sarcoma: Report of 39 cases and literature review. Pathol Res Pract. 2016;212:817-24 pubmed publisher
    ..Immunohistochemistry and special staining showed that the positive rates for myeloperoxidase, CD43, CD34, CD117, CD68, Lysozyme, CD99, and naphthol AS-D chloroacetate esterase were 92.1% (35/38), 91.3% (21/23), 44...
  59. Kim H, Lee J, Heo H, Yang S, Ha K, Park W, et al. Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway. Cell Biosci. 2016;6:50 pubmed publisher
    ..During hematopoietic differentiation of hPSCs, ER-? is persistently maintained and hematopoietic phenotypes (CD34 and CD45) were exclusively detected in ER-? positive cells...
  60. Leberfinger D, Badman K, Roig J, Loos T. Improved planning of leukapheresis endpoint with customized prediction algorithm: minimizing collection days, volume of blood processed, procedure time, and citrate toxicity. Transfusion. 2017;57:685-693 pubmed publisher
    ..of a customized predictive algorithm that estimates how many blood volumes are required to process for a targeted CD34 cell dose...
  61. Rahmani M, Nkwocha J, Hawkins E, Pei X, Parker R, Kmieciak M, et al. Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells. Cancer Res. 2018;78:3075-3086 pubmed publisher
    ..Venetoclax/GDC-0980 markedly induced apoptosis in primitive CD34+/38-/123+ AML cell populations but not in normal hematopoietic progenitor CD34..
  62. Martins L, Morita A, Broto G, Takakura É, da Silva S, Tomiotto Pellissier F, et al. Interferon-gamma in mobilized stem cells: A possible prognostic marker in early post-transplant management in multiple myeloma. Cytokine. 2018;108:127-135 pubmed publisher
    ..Association of these cytokines with certain factors such as mobilized CD34 + cells/kg, staging, response to treatment and outcome were analyzed. The median baseline IFN-γ level was 826...
  63. Iachininoto M, Capodimonti S, Podda M, Valentini C, Bianchi M, Leone A, et al. In vitro cardiomyocyte differentiation of umbilical cord blood cells: crucial role for c-kit(+) cells. Cytotherapy. 2015;17:1627-37 pubmed publisher
    ..Although c-kit(+) cells revealed an immature gene profile, with high expression of CD34, CD133, aldehyde dehydrogenase-A1 and c-myc RNAs, purified c-kit(+) cells did not succeed in differentiating into ..
  64. Winkler I, Wiercinska E, Barbier V, Nowlan B, Bonig H, Levesque J. Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak. Exp Hematol. 2016;44:303-14.e1 pubmed publisher
    ..This is based on surrogate markers for HSC mobilization, such as CD34(+) cells and colony-forming activity in blood...
  65. Woudstra P, Kalkman D, den Heijer P, Menown I, Erglis A, Suryapranata H, et al. 1-Year Results of the REMEDEE Registry: Clinical Outcomes After Deployment of the Abluminal Sirolimus-Coated Bioengineered (Combo) Stent in a Multicenter, Prospective All-Comers Registry. JACC Cardiovasc Interv. 2016;9:1127-34 pubmed publisher
    ..The Combo stent combines an abluminal biodegradable coating eluting sirolimus and a luminal anti-CD34(+) antibody layer to attract endothelial progenitor cells in order to promote vessel healing, thus preventing ..
  66. Li X, Xia C, Wang T, Liu L, Zhao Q, Yang D, et al. Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells. Stem Cell Res. 2017;21:32-39 pubmed publisher
    ..UM171 facilitated generation of robust CD34+CD45+ derivatives that formed more and larger sized CFU-GM as well as larger sized CFU-Mix...
  67. Salter B, Smith S, Mukherjee M, Plante S, Krisna S, Nusca G, et al. Human Bronchial Epithelial Cell-Derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation. Am J Respir Cell Mol Biol. 2017;: pubmed publisher
    ..Overnight culture of CD34+ cells with IL-5 and TSLP synergistically increased GATA-2 and CEBP-alpha mRNA expression...
  68. Holland A, Tarran S, Medbury H, Guiffre A. Are fibrocytes present in pediatric burn wounds?. J Burn Care Res. 2008;29:619-26 pubmed publisher
    ..After fixation and sectioning, immunohistochemistry (IHC) staining was performed for CD34, pro-collagen I, alpha smooth muscle actin, transforming growth factor beta1 and Leucocyte Specific Protein-1 (LSP-..
  69. Declercq H, Forsyth R, Verbruggen A, Verdonk R, Cornelissen M, Verdonk P. CD34 and SMA expression of superficial zone cells in the normal and pathological human meniscus. J Orthop Res. 2012;30:800-8 pubmed publisher
    ..injury) and osteoarthritic (OA) knee menisci versus normal menisci after PAS-AB, SAF-O-FG, and immunostaining for CD34, CD31, and smooth muscle actin (SMA)...
  70. Ajili F, Kacem M, Tounsi H, Darouiche A, Enayfer E, Chebi M, et al. Prognostic impact of angiogenesis in nonmuscle invasive bladder cancer as defined by microvessel density after immunohistochemical staining for CD34. Ultrastruct Pathol. 2012;36:336-42 pubmed publisher
    ..The frozen sections of 28 non muscle invasive bladder cancer specimens were stained with CD34 antibody to label the vascular endothelium using the standard streptavidin-biotin immunoperoxidase method...
  71. Husseini M, Wang G, Patrick C, Crookshank J, MacFarlane A, Noel J, et al. Heme Oxygenase-1 Induction Prevents Autoimmune Diabetes in Association With Pancreatic Recruitment of M2-Like Macrophages, Mesenchymal Cells, and Fibrocytes. Endocrinology. 2015;156:3937-49 pubmed publisher
    ..Most interstitial cells expressed the mesenchymal marker vimentin and the hematopoietic marker CD34. Spindle-shaped, CD34(+)vimentin(+) cells coexpressed collagen V, characteristic of fibrocytes...
  72. Rastogi P, Naseem S, Varma N, Varma S. Nucleophosmin mutation in de-novo acute myeloid leukemia. Asia Pac J Clin Oncol. 2016;12:77-85 pubmed publisher
    ..Immunophenotypically, there was statistically significant negativity for CD34, strong association with monocytic markers (especially CD11c), CD123 was seen at higher frequency and higher mean ..
  73. Wang X, Li T, Wang W, Yuan W, Liu H, Cheng Y, et al. Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2. J Immunol. 2016;196:4090-9 pubmed publisher
    Cytokine-like 1 (CYTL1) is a novel potential cytokine that was first identified in CD34(+) cells derived from bone marrow and cord blood, and it was also found using our immunogenomics strategy...
  74. Tomasello L, Musso R, Cillino G, Pitrone M, Pizzolanti G, Coppola A, et al. Donor age and long-term culture do not negatively influence the stem potential of limbal fibroblast-like stem cells. Stem Cell Res Ther. 2016;7:83 pubmed publisher
    ..capability were evaluated; cytofluorimetric assay was performed to detect the immunophenotypes HLA-DR, CD45, and CD34 and the principle stem cell markers ABCG2, OCT3/4, and NANOG...
  75. Zhang M, Suárez M, Bosley T, Rodriguez F. Clinicopathological features of peripheral nerve sheath tumors involving the eye and ocular adnexa. Hum Pathol. 2017;63:70-78 pubmed publisher
    ..2%), and inflammation (14.3%). Available immunostains included S100 (+ in 15/15 cases), EMA (+ in 2/4 cases), CD34 (+ in 4/4 cases), and Ki-67 (<1% in 4/4 cases). Among 10 schwannomas, 8 were conventional and 2 were plexiform...
  76. Stover J, Shaw J, Kuchibhatla M, Horwitz M, Engemann A. Evaluation of Hematopoietic Stem Cell Mobilization Rates with Early Plerixafor Administration for Adult Stem Cell Transplantation. Biol Blood Marrow Transplant. 2017;23:1290-1294 pubmed publisher
    ..The primary outcome was CD34+ cell mobilization success rates when plerixafor was administered 11?±?2 hours (standard administration ..
  77. Wang J, Xu Y, Wan H, Hu J. Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress. Biochem Biophys Res Commun. 2018;497:241-247 pubmed publisher
    ..is significantly more effective in inducing caspase-dependent apoptosis in CML cell line K562 and primary CML CD34 than normal bone marrow (NBM) CD34 cells...
  78. Simmons D, Satterthwaite A, Tenen D, Seed B. Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells. J Immunol. 1992;148:267-71 pubmed
    b>CD34 is a 115-kDa transmembrane glycoprotein of unknown function that is expressed on human hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues...
  79. Xu Z, Sheng L, Lou Y, Mu Q, Zhang Y, Zhang Y, et al. Supporting Effect of Umbilical Cord Blood-Derived Mesenchymal Stem Cells on CD34+ Cell Proliferation and Its Mechanism. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:802-8 pubmed publisher
    ..UCB-derived MSCs as a feeder layer can be an alternative approach for ex vivo expansion of HSCs, and the cytokines by secreted UCB-MSCs may mediate the supportive role of MSC to HSC proliferation. ..
  80. Al Mussaed E, Osman H, Elyamany G. Simultaneous existence of acute myeloid leukemia and chronic lymphocytic leukemia: a case report. BMC Cancer. 2016;16:739 pubmed publisher
    ..were characterized by a typical CLL immunophenotype: CD19+, CD5+, CD23+, CD20+?(dim) and negative for FMC7, CD34, CD10 and TdT. Cytogenetic studies were negative for CLL and AML panels...
  81. Adair J, Waters T, Haworth K, Kubek S, Trobridge G, Hocum J, et al. Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy. Nat Commun. 2016;7:13173 pubmed publisher
    ..for semi-automated cell isolation and culture equipment to permit complete benchtop generation of gene-modified CD34+ blood cell products for transplantation...
  82. Agaimy A, Michal M, Giedl J, Hadravsky L, Michal M. Superficial acral fibromyxoma: clinicopathological, immunohistochemical, and molecular study of 11 cases highlighting frequent Rb1 loss/deletions. Hum Pathol. 2017;60:192-198 pubmed publisher
    ..To date, less than 300 cases have been reported. SAFs consistently express CD34, but other diagnostic markers or specific genetic alterations have not been established yet...
  83. Binnemars Postma K, Bansal R, Storm G, Prakash J. Targeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer. FASEB J. 2017;: pubmed publisher
    ..and metastatic niche markers [Mmp-2 (matrix metalloproteinase-2), Postn (periostin), and Cd34] in mice with increasing growth of primary tumors...
  84. Kenig Kozlovsky Y, Scott R, Onay T, Carota I, Thomson B, Gil H, et al. Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels. J Am Soc Nephrol. 2018;29:1097-1107 pubmed publisher
    ..homeobox protein 1 and vascular endothelial growth factor receptor 3) as well as blood endothelial markers (CD34, endomucin, platelet endothelial cell adhesion molecule 1, and plasmalemmal vesicle-associated protein)...
  85. Sirma Ekmekci S, G Ekmekci C, Kandilci A, Güleç C, Akbiyik M, Emrence Z, et al. SET oncogene is upregulated in pediatric acute lymphoblastic leukemia. Tumori. 2012;98:252-6 pubmed publisher
    ..It has been shown that SET is upregulated in BCR-ABL1-positive cell lines, patient-derived chronic myeloid leukemia CD34-positive cells, and some solid tumors.
  86. Al Mawali A, Gillis D, Lewis I. Immunoprofiling of leukemic stem cells CD34+/CD38-/CD123+ delineate FLT3/ITD-positive clones. J Hematol Oncol. 2016;9:61 pubmed publisher
    ..cells called leukemic stem cells (LSCs) capable of propagating leukemia that are enriched in the CD34+/CD38- fraction...
  87. van Schaarenburg R, Suurmond J, Habets K, Brouwer M, Wouters D, Kurreeman F, et al. The production and secretion of complement component C1q by human mast cells. Mol Immunol. 2016;78:164-170 pubmed publisher
    ..Mast cells were generated in vitro from CD34+ progenitor cells from buffy coats or cord blood...
  88. Terayama H, Endo H, Tsukamoto H, Matsumoto K, Umezu M, Kanazawa T, et al. Acetamiprid Accumulates in Different Amounts in Murine Brain Regions. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..However, the treatments did not affect brain histology or expression of CD34. ACE concentrations were significantly higher in the midbrain of ACE-treated mice than that of the normal and ..
  89. Nguyen M, Okina E, Chai X, Tan K, Hovatta O, Ghosh S, et al. Differentiation of Human Embryonic Stem Cells to Endothelial Progenitor Cells on Laminins in Defined and Xeno-free Systems. Stem Cell Reports. 2016;7:802-816 pubmed publisher
    ..We were able to generate ?95% functional EPCs defined as VEGFR2+CD34+CD31+VE-Cadherin+...
  90. Dobi D, Laszik Z. In Situ Hybridization and Double Immunohistochemistry for the Detection of VEGF-A mRNA and CD34/Collagen IV Proteins in Renal Transplant Biopsies. Methods Mol Biol. 2018;1788:131-143 pubmed publisher
    ..Here, we present the most prevalent current alternatives for step (1) and describe a three-plex staining and image acquisition platform that captures the spatial distribution of macromolecules from two different species. ..
  91. Ianniciello A, Dumas P, Drullion C, Guitart A, Villacreces A, Peytour Y, et al. Chronic myeloid leukemia progenitor cells require autophagy when leaving hypoxia-induced quiescence. Oncotarget. 2017;8:96984-96992 pubmed publisher
    ..Using immunomagnetic sorted normal and CML CD34+ cells, we inhibited the autophagic process by lentiviral infection expressing shATG7 or using a Vps34 ..
  92. Fackler M, Civin C, Sutherland D, Baker M, May W. Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells. J Biol Chem. 1990;265:11056-61 pubmed
    The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. We found that CD34 is a phosphoprotein and therefore examined the regulation of its phosphorylation...