CD33

Summary

Gene Symbol: CD33
Description: CD33 molecule
Alias: SIGLEC-3, SIGLEC3, p67, myeloid cell surface antigen CD33, CD33 antigen (gp67), CD33 molecule transcript, gp67, sialic acid-binding Ig-like lectin 3
Species: human
Products:     CD33

Top Publications

  1. Wellhausen S, Peiper S. CD33: biochemical and biological characterization and evaluation of clinical relevance. J Biol Regul Homeost Agents. 2002;16:139-43 pubmed
  2. Hollingworth P, Harold D, Sims R, Gerrish A, Lambert J, Carrasquillo M, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet. 2011;43:429-35 pubmed publisher
    ..0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3...
  3. Freeman S, Kelm S, Barber E, Crocker P. Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood. 1995;85:2005-12 pubmed
    b>CD33 is a member of the Ig superfamily that is restricted to cells of the myelomonocytic lineage but whose functions and binding properties are unknown...
  4. Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan M, et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet. 2008;83:623-32 pubmed publisher
  5. Naj A, Jun G, Beecham G, Wang L, Vardarajan B, Buros J, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011;43:436-41 pubmed publisher
    ..6 × 10(-9)), EPHA1 (rs11767557; stages 1, 2 and 3, P(M) = 6.0 × 10(-10)) and CD33 (rs3865444; stages 1, 2 and 3, P(M) = 1.6 × 10(-9))...
  6. Tarry Adkins J, Fernandez Twinn D, Chen J, Hargreaves I, Neergheen V, Aiken C, et al. Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats. Dis Model Mech. 2016;9:1221-1229 pubmed
    ..I, complex II-III and complex IV (all markers of functional mitochondria), and increased xanthine oxidase (XO), p67phox and nuclear-factor kappa-light-chain-enhancer of activated B-cells (NF-?B)...
  7. Zhou L, Miao K, Yin B, Li H, Fan J, Zhu Y, et al. Cardioprotective Role of Myeloid-Derived Suppressor Cells in Heart Failure. Circulation. 2018;138:181-197 pubmed publisher
    ..The percentage of human leukocyte antigen-D-related (HLA-DR)-CD33+CD11b+ MDSCs in the blood of patients with HF was significantly increased and positively ..
  8. Thandavarayan R, Giridharan V, Sari F, Arumugam S, Veeraveedu P, Pandian G, et al. Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-ĸB signaling pathways after streptozotocin-induced diabetes mellitus. Cell Physiol Biochem. 2011;28:911-22 pubmed publisher
    ..Moreover, reactive oxygen species, left ventricular expression of NADPH oxidase subunits, p22 phox, p67 phox, and Nox4, and lipid peroxidation levels were significantly increased in diabetic DN 14-3-3mice compared to ..
  9. den Boer M, Kapaun P, Pieters R, Kazemier K, Janka Schaub G, Veerman A. Myeloid antigen co-expression in childhood acute lymphoblastic leukaemia: relationship with in vitro drug resistance. Br J Haematol. 1999;105:876-82 pubmed
    ..MTT) assay was used to compare the in vitro cytotoxicity of 14 drugs between 60 My+ (CD13+ and/or CD33+) and 107 My- ALL children at initial diagnosis...

More Information

Publications134 found, 100 shown here

  1. Niu H, Li Y, Li H, Chi Y, Zhuang M, Zhang T, et al. Matrix metalloproteinase 12 modulates high-fat-diet induced glomerular fibrogenesis and inflammation in a mouse model of obesity. Sci Rep. 2016;6:20171 pubmed publisher
    ..reduced glomerular matrix accumulation, and downregulated the expression of NADPH oxidase 4 and the subunit-p67(phox), indicating the inhibition of renal oxidative stress...
  2. Ansari M, Roberts K, Scheff S. A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma. Free Radic Biol Med. 2014;77:21-9 pubmed publisher
    ..In addition we evaluated the translocation of cytosolic NOX proteins (p67(Phox), p47(Phox), and p40(Phox)) to the membrane, along with total NO and the activation (phosphorylation) of ..
  3. Koka P. Biomarker discovery and biotherapeutics applications of photosynthetic light-harvesting and bioluminescence light-emitting chromophore-protein complexes in stem cell biology and regenerative medicine. J Stem Cells. 2014;9:127-33 pubmed publisher
    ..Markers - Melan-A/Mart-1 of melanoma), normal immune response cells (Human/Mouse/species cellular MHC/TCR/CD45/CD33/CD56/CD19/CD41), and of types of stem cells (CD34/CD38/c-Mpl/Oct4/Neuropilin-1/SOX17)...
  4. Kumar V, Singh B, Chauhan A, Singh D, Patel D, Singh C. Minocycline Rescues from Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration: Biochemical and Molecular Interventions. Mol Neurobiol. 2016;53:2761-2777 pubmed publisher
    ..Besides, Zn increased an association of NADPH oxidase subunit p67(phox) with membrane, cytochrome c release from the mitochondria and cleavage of pro-caspase 3...
  5. Qing X, Qing A, Ji P, French S, Mason H. Mixed phenotype (T/B/myeloid) extramedullary blast crisis as an initial presentation of chronic myelogenous leukemia. Exp Mol Pathol. 2018;104:130-133 pubmed publisher
    ..subset), CD19 (subset), CD79a, PAX-5 (subset), CD34, CD38, CD117 (subset), HLA-DR (subset), CD11b, CD13 (subset), CD33 (subset), and weak cytoplasmic myeloperoxidase, without co-expression of surface CD3, CD4, CD8, CD20, CD22, CD14, ..
  6. Fisher A. The phospholipase A2 activity of peroxiredoxin 6. J Lipid Res. 2018;59:1132-1147 pubmed publisher
    ..MJ33)], and by two naturally occurring proteins (surfactant protein A and p67phox), but not by bromoenol lactone...
  7. Gonzàlez Juncà A, Driscoll K, Pellicciotta I, Du S, Lo C, Roy R, et al. Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment. Cancer Immunol Res. 2019;7:306-320 pubmed publisher
    ..stimulating factor (GM-CSF) and interleukin 6 (IL6) amplified HLA-DRlowCD14+CD11b+CD33+ myeloid-derived suppressor cells (MDSCs) at the expense of macrophage and dendritic cell (DC) ..
  8. Khan Z, Shen X, Bernstein E, Giani J, Eriguchi M, Zhao T, et al. Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils. Blood. 2017;130:328-339 pubmed publisher
    ..Analysis of membrane p47-phox and p67-phox indicates that ACE increases reduced NAD phosphate oxidase activity but does not increase expression of these ..
  9. Cowley A, Yang C, Zheleznova N, Staruschenko A, Kurth T, Rein L, et al. Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. Hypertension. 2016;67:440-50 pubmed publisher
    ..Before the development of hypertension, RNA expression levels of Nox subunits Nox2, p67(phox), and p22(phox) were found to be significantly lower (P<0...
  10. Thandavarayan R, Watanabe K, Ma M, Gurusamy N, Veeraveedu P, Konishi T, et al. Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus. Am J Physiol Heart Circ Physiol. 2009;297:H911-9 pubmed publisher
    ..Moreover, LV expression of NADPH oxidase subunits, p22(phox), p67(phox), gp91(phox), and Nox4, reactive oxygen species and lipid peroxidation levels were significantly increased in ..
  11. Stawowczyk M, Naseem S, Montoya V, Baker D, Konopka J, Reich N. Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic Candida albicans Infection. MBio. 2018;9: pubmed publisher
    ..leukocytes, and we demonstrate that IFIT2 is a binding partner of a critical regulatory subunit of NADPH oxidase, p67phox Since the administration of IFN has been used therapeutically to combat viral infections, cancer, ..
  12. Du Z, Yang Q, Liu L, Li S, Zhao J, Hu J, et al. NADPH oxidase 2-dependent oxidative stress, mitochondrial damage and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging rats. Neuroscience. 2015;286:281-92 pubmed publisher
    ..levels of H2O2 and the expression of NADPH oxidase 2 (NOX2) and its corresponding subunits P22(phox), P47(phox) and P67(phox) were greatly increased in the ventral cochlear nucleus (VCN) of D-gal-treated rats as compared with controls...
  13. Cai L, Stevenson J, Geng X, Peng C, Ji X, Xin R, et al. Combining Normobaric Oxygen with Ethanol or Hypothermia Prevents Brain Damage from Thromboembolic Stroke via PKC-Akt-NOX Modulation. Mol Neurobiol. 2017;54:1263-1277 pubmed publisher
    ..ROS levels, NOX activity, and the protein expression of NOX subunits p22phox, p47phox, p67phox, gp91phox, as well as PKC-? and phosphorylated Akt were measured at 3 and 24 h after rt-..
  14. Hsu H, Tseng Y, Wong W, Liu C, Lo Y. Resveratrol prevents nanoparticles-induced inflammation and oxidative stress via downregulation of PKC-? and NADPH oxidase in lung epithelial A549 cells. BMC Complement Altern Med. 2018;18:211 pubmed publisher
    ..A549 cells, CBNPs significantly enhanced oxidative stress by upregulation of Nox2 and membrane expression of p67phox accompanied with increase of ROS production...
  15. Zhou Y, An L, Chaerkady R, Mittereder N, Clarke L, Cohen T, et al. Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils. Sci Rep. 2018;8:15228 pubmed publisher
    ..subunits of the oxidative burst machinery, p47phox (also known as neutrophil cytosol factor 1, NCF1) and p67phox (NCF2)...
  16. Schweikl H, Widbiller M, Krifka S, Klement J, Petzel C, Bolay C, et al. Interaction between LPS and a dental resin monomer on cell viability in mouse macrophages. Dent Mater. 2016;32:1492-1503 pubmed publisher
    ..Expression of NOS (nitric oxide synthase), p47phox and p67phox subunits of NADPH oxidase, catalase or heme oxygenase (HO-1) was associated with HEMA- or LPS-..
  17. Wen C. Development and characterization of a cell line from tilapia head kidney with melanomacrophage characteristics. Fish Shellfish Immunol. 2016;49:442-9 pubmed publisher
    ..Transcripts of CD33, CD53, CD82, CD205, macrophage colony stimulating factor receptor, GATA2, and GATA3 that are specific for ..
  18. Ahn B, Coblentz P, Beharry A, Patel N, Judge A, Moylan J, et al. Diaphragm Abnormalities in Patients with End-Stage Heart Failure: NADPH Oxidase Upregulation and Protein Oxidation. Front Physiol. 2016;7:686 pubmed publisher
    ..05). Patients also had increased protein levels of Nox2 subunits (p47phox, p22phox, and p67phox) and total p47phox phosphorylation, while phospho-to-total p47phox levels were ..
  19. Zhao J, Niu X, Wang Z, Lu H, Lin X, Lu Q. Histiocytic sarcoma combined with acute monocytic leukemia: a case report. Diagn Pathol. 2015;10:110 pubmed publisher
    ..increasing leukocytes, up to 50% blasts in BM in December 2013, and abnormal cells positive for CD117, CD13, CD33, HLA-DR, CD34, CD11c, CD38, and myeloperoxidase...
  20. Zhang Z, Jin S, Teng X, Duan X, Chen Y, Wu Y. Hydrogen sulfide attenuates cardiac injury in takotsubo cardiomyopathy by alleviating oxidative stress. Nitric Oxide. 2017;67:10-25 pubmed publisher
    ..NADPH Oxidase 4 (NOX4) and p67 protein expressions significantly increased in TCM cardiac tissues...
  21. Wang Y, Liu D, Zhang H, Wang Y, Wei L, Liu Y, et al. Ultrafine carbon particles promote rotenone-induced dopamine neuronal loss through activating microglial NADPH oxidase. Toxicol Appl Pharmacol. 2017;322:51-59 pubmed publisher
    ..recognized by microglial surface MAC-1 receptor and consequently promoted rotenone-induced p47phox and p67phox translocation assembling active NADPH oxidase...
  22. Castelli R, Cugno M, Gianelli U, Pancrazzi A, Vannucchi A. Neutrophilic progression in a case of polycytemia vera mimicking chronic neutrophilic leukemia: clinical and molecular characterization. Pathol Res Pract. 2015;211:341-3 pubmed publisher
    ..constituted less than 1% of total marrow nucleated cells, mature granulocytes demonstrated persistent expression of CD33. Mutational analysis of the gene CSF3R by PCR amplification revealed no alterations in exons 14-17, including ..
  23. Zhang S, Ji S, Bai X, Yuan F, Zhang L, Li J. L-3-n-butylphthalide attenuates cognitive deficits in db/db diabetic mice. Metab Brain Dis. 2019;34:309-318 pubmed publisher
    ..Finally, the expression levels of MDA, SOD, 8-OHdG, and NADPH oxidase subunits gp91 and p67, as well as the expression of NF-κB p65, TNF-α, IL-1β and caspase-3 were measured by Western blot, RT-PCR and ..
  24. Palus M, Sohrabi Y, Broman K, Strnad H, Síma M, Ruzek D, et al. A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus. BMC Neurosci. 2018;19:39 pubmed publisher
    ..BALB/c and STS that change RNA stability and genes' functions led to detection of 9 potential candidate genes: Cd33, Klk1b22, Siglece, Klk1b16, Fut2, Grwd1, Abcc6, Otog, and Mkrn3...
  25. Chedid P, Boussetta T, Dang P, Belambri S, Marzaioli V, Fasseau M, et al. Vasoactive intestinal peptide dampens formyl-peptide-induced ROS production and inflammation by targeting a MAPK-p47phox phosphorylation pathway in monocytes. Mucosal Immunol. 2017;10:332-340 pubmed publisher
    ..multicomponent enzyme composed of membrane-associated cytochrome b588 and cytosolic components p47phox, p67phox, p40phox, and rac1/2...
  26. Guo S, Yao Q, Ke Z, Chen H, Wu J, Liu C. Resveratrol attenuates high glucose-induced oxidative stress and cardiomyocyte apoptosis through AMPK. Mol Cell Endocrinol. 2015;412:85-94 pubmed publisher
    ..markedly suppressed the increased activity of NADPH oxidase and Rac1, as well as the enhanced expression of p67(phox), p47(phox), and gp91(phox) induced by high glucose...
  27. Christiansson L, Söderlund S, Mangsbo S, Hjorth Hansen H, Höglund M, Markevärn B, et al. The tyrosine kinase inhibitors imatinib and dasatinib reduce myeloid suppressor cells and release effector lymphocyte responses. Mol Cancer Ther. 2015;14:1181-91 pubmed publisher
    ..gov identifier: NCT00852566) were investigated for the presence of CD11b(+)CD14(-)CD33(+) myeloid cells and inhibitory molecules (arginase I, myeloperoxidase, IL10) as well as the presence of natural ..
  28. Vendramin A, Gimondi S, Bermema A, Longoni P, Rizzitano S, Corradini P, et al. Graft monocytic myeloid-derived suppressor cell content predicts the risk of acute graft-versus-host disease after allogeneic transplantation of granulocyte colony-stimulating factor-mobilized peripheral blood stem cells. Biol Blood Marrow Transplant. 2014;20:2049-55 pubmed publisher
    ..induces an expansion of myeloid cells displaying the phenotype of monocytic MDSCs (Lin(low/neg)HLA-DR(-)CD11b(+)CD33(+)CD14(+)) with the ability to suppress alloreactive T cells in vitro, therefore meeting the definition of MDSCs...
  29. Shao D, Miao N, Li J. Involvement of spliced X-box binding protein 1 in renal fibrosis induced by unilateral ureteral obstruction in mice. Sheng Li Xue Bao. 2016;68:157-64 pubmed
    ..Real-time polymerase chain reaction was performed to assess NADPH oxidase subunits p47-phox and p67-phox mRNA levels...
  30. Secundino I, Lizcano A, Roupé K, Wang X, Cole J, Olson J, et al. Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation. J Mol Med (Berl). 2016;94:219-33 pubmed publisher
    Inhibitory CD33-related Siglec receptors regulate immune cell activation upon engaging ubiquitous sialic acids (Sias) on host cell surface glycans...
  31. Grobe K, Powell L. Role of protein kinase C in the phosphorylation of CD33 (Siglec-3) and its effect on lectin activity. Blood. 2002;99:3188-96 pubmed
    b>CD33 (Siglec-3) is a marker of myeloid progenitor cells, mature myeloid cells, and most myeloid leukemias...
  32. Zhao Q, Zhang J, Wang H. PGC-1α limits angiotensin II-induced rat vascular smooth muscle cells proliferation via attenuating NOX1-mediated generation of reactive oxygen species. Biosci Rep. 2015;35: pubmed publisher
    ..Analysis of several key subunits of NADPH oxidase (Rac1, p22(phox), p40(phox), p47(phox) and p67(phox)) and mitochondrial ROS revealed that these mechanisms were not responsible for the observed effects of PGC-1Î..
  33. Kervarrec T, Gaboriaud P, Berthon P, Zaragoza J, Schrama D, Houben R, et al. Merkel cell carcinomas infiltrated with CD33+ myeloid cells and CD8+ T cells are associated with improved outcome. J Am Acad Dermatol. 2018;78:973-982.e8 pubmed publisher
    ..Macrophages, neutrophils, and myeloid-derived suppressor cells were characterized by the following markers: CD68, CD33, CD163, CD15, CD33, and human leukocyte antigen-DR...
  34. Li X, Shen N, Zhang S, Liu J, Jiang Q, Liao M, et al. CD33 rs3865444 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese, European, and North American Populations. Mol Neurobiol. 2015;52:414-21 pubmed publisher
    The CD33 rs3865444 polymorphism was first identified to be associated with Alzheimer's disease (AD) in European population...
  35. Ham B, Wang N, D Costa Z, Fernández M, Bourdeau F, Auguste P, et al. TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases. Cancer Res. 2015;75:5235-47 pubmed publisher
    ..analysis of liver metastases from chemotherapy-naïve colon cancer patients confirmed the presence of CD33(+)HLA-DR(-)TNFR2(+) myeloid cells in the periphery of hepatic metastases...
  36. Hamilton Reeves J, Bechtel M, Hand L, Schleper A, Yankee T, Chalise P, et al. Effects of Immunonutrition for Cystectomy on Immune Response and Infection Rates: A Pilot Randomized Controlled Clinical Trial. Eur Urol. 2016;69:389-92 pubmed publisher
    ..MDSC count (Lin- CD11b+ CD33+) was significantly different between the groups over time (p=0...
  37. Tajik S, Badalzadeh M, Fazlollahi M, Houshmand M, Zandieh F, Khandan S, et al. A Novel CYBB Mutation in Chronic Granulomatous Disease in Iran. Iran J Allergy Asthma Immunol. 2016;15:426-429 pubmed
    ..is composed of membrane-bound gp91-phox and p22-phox subunits, and cytosolic subunits consisting of p47-phox, p67-phox, and p40-phox. A mutation in CYBB gene encoding gp91-phox located on chromosome Xp21.1, leads to X-linked CGD...
  38. Dong T, Jiang Y, Li Z, Ouyang H, Zhang Q. [Detection and analysis of immune molecules in leukemia cell surfaces of acute promyelocytic leukemia]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:664-667 pubmed
    ..Results The expression intensity and percentage of typical APL phenotypes were: myeloperoxidase (MPO) and CD33 were consistently expressed (100%); CD38 (82.35%), CD13 (64.71%), CD64 (50%), CD123 (47.06%) and CD117 (44...
  39. Corrente F, Bellesi S, Metafuni E, Puggioni P, Marietti S, Ciminello A, et al. Role of flow-cytometric immunophenotyping in prediction of BCR/ABL1 gene rearrangement in adult B-cell acute lymphoblastic leukemia. Cytometry B Clin Cytom. 2017;: pubmed publisher
    ..Patients with gene rearrangement had a greater frequency of CD66c, CD13 and CD33 positivity compared with BCR/ABL1-negative cases...
  40. Walter R, Raden B, Zeng R, Hausermann P, Bernstein I, Cooper J. ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2. J Leukoc Biol. 2008;83:200-11 pubmed
    The leukocyte CD33-related sialic acid-binding Ig-like lectins (Siglecs) are implicated in glycan recognition and host defense against and pathogenicity of sialylated pathogens...
  41. Plesa C, Chelghoum Y, Plesa A, Elhamri M, Tigaud I, Michallet M, et al. Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia: a single-institution experience. Cancer. 2008;112:572-80 pubmed
    ..The authors investigated expression of the membrane antigens CD13, CD15, CD33, and CD34 by flow cytometry in elderly patients with newly diagnosed AML and analyzed whether these parameters had ..
  42. Bovio I, Allan R. The expression of myeloid antigens CD13 and/or CD33 is a marker of ALK+ anaplastic large cell lymphomas. Am J Clin Pathol. 2008;130:628-34 pubmed publisher
    ..and 11 ALK-) with a particular emphasis on the aberrant expression of the myeloid associated antigens CD13 and/or CD33. All ALCLs expressed CD45, HLA-DR, and CD30...
  43. Torres L, Garcia R, Blois A, Dati L, Durão A, Alves A, et al. Exposure of Neonatal Mice to Tobacco Smoke Disturbs Synaptic Proteins and Spatial Learning and Memory from Late Infancy to Early Adulthood. PLoS ONE. 2015;10:e0136399 pubmed publisher
    ..memory were evaluated in the Morris water maze during infancy (P20-P29), adolescence (P37-P42) and adulthood (P67-P72)...
  44. Dimatelis J, Vermeulen I, Bugarith K, Stein D, Russell V. Female rats are resistant to developing the depressive phenotype induced by maternal separation stress. Metab Brain Dis. 2016;31:109-19 pubmed publisher
    ..MS decreased the time females spent immobile and increased time actively swimming in the forced swim test at P67 but not at P99...
  45. Al Hassan L, Opazo A, Lopes B, Mahallawy H, Amyes S. Variations in IS6 promoters alter the expression of carbapenem resistance in related strains of Acinetobacter baumannii. J Glob Antimicrob Resist. 2015;3:5-8 pubmed publisher
    ..two isolates were positive for the intrinsic blaOXA-64 gene, and the MICs for isolates AB-14298 and AB-P67 were 8mg/L and 64mg/L for imipenem and 2mg/L and 16mg/L for meropenem, respectively...
  46. Mortland L, Alonzo T, Walter R, Gerbing R, Mitra A, Pollard J, et al. Clinical significance of CD33 nonsynonymous single-nucleotide polymorphisms in pediatric patients with acute myeloid leukemia treated with gemtuzumab-ozogamicin-containing chemotherapy. Clin Cancer Res. 2013;19:1620-7 pubmed publisher
    The purpose of this study was to evaluate clinical implications of CD33 single-nucleotide polymorphisms (SNP) in pediatric patients with acute myeloid leukemia (AML) treated with gemtuzumab-ozogamicin (GO)-based therapy...
  47. Sanford D, Garcia Manero G, Jorgensen J, Konoplev S, Pierce S, Cortes J, et al. CD33 is frequently expressed in cases of myelodysplastic syndrome and chronic myelomonocytic leukemia with elevated blast count. Leuk Lymphoma. 2016;57:1965-8 pubmed publisher
  48. Minagawa K, Jamil M, Al Obaidi M, Pereboeva L, Salzman D, Erba H, et al. In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia. PLoS ONE. 2016;11:e0166891 pubmed publisher
    ..We developed an immunotherapeutic strategy targeting the CD33 myeloid antigen, expressed in ~ 85-90% of patients with acute myeloid leukemia, using chimeric antigen receptor ..
  49. Lerman I, Garcia Hernandez M, Rangel Moreno J, Chiriboga L, Pan C, Nastiuk K, et al. Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase. Mol Cancer Res. 2017;15:1138-1152 pubmed publisher
    ..cells in vitro IHC on human prostate cancer clinical biopsies revealed coexpression of NE and infiltrating CD33+ MDSCs...
  50. Nerreter T, Köchel C, Jesper D, Eichelbrönner I, Putz E, Einsele H, et al. Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3. Exp Hematol. 2014;42:773-82.e1-3 pubmed publisher
    ..Thus, the use of dasatinib or blocking Siglec antibodies as adjuvants in this setting to induce stronger immune responses is worthy of further study. ..
  51. Sun H, Li Y, Zhang Z, Ju Y, Li L, Zhang B, et al. Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia. Int J Hematol. 2015;102:579-86 pubmed publisher
    ..In the present study, we found that MDSCs (CD33 + CD11b + HLA-DR(low/neg)) in bone marrow were significantly increased in adult acute myeloid leukemia (AML) ..
  52. Wang S, Chu C, Guo M, Jiang L, Nie H, Zhang W, et al. Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons. J Neuroinflammation. 2016;13:158 pubmed publisher
    ..Western blots and confocal images were utilized to analyze membrane translocation of p47 (phox) and p67 (phox) , phosphorylation of p47 (phox) and Erk1/2 kinase, and binding of α-Syn peptides to gp91 (phox) ...
  53. Takei Y, Sasaki S, Fujiwara T, Takahashi E, Muto T, Nakamura Y. Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. Cytogenet Cell Genet. 1997;78:295-300 pubmed
    We have isolated a novel gene that encodes a protein sharing significant similarity with myeloid antigen CD33. The complete cDNA contains an open reading frame of 1,326 nucleotides encoding 442 amino acids...
  54. Li J, Zhou Y, Zhang W, Bao C, Xie Z. Relief of oxidative stress and cardiomyocyte apoptosis by using curcumin nanoparticles. Colloids Surf B Biointerfaces. 2017;153:174-182 pubmed publisher
    ..the increased activity of Rac1, as well as the enhanced expression of p22phox, p47phox, p67phox and gp91phox induced by PA...
  55. Wei A, Tiong I. Midostaurin, enasidenib, CPX-351, gemtuzumab ozogomycin and venetoclax bring new hope to AML. Blood. 2017;: pubmed publisher
    ..AML with myelodysplasia-related changes and finally, resurgence of an antibody-drug conjugate designed to target CD33 (gemtuzumab ozogomycin; GO)...
  56. Drgona L, Gudiol C, Lanini S, Salzberger B, Ippolito G, Mikulska M. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid or myeloid cells surface antigens [II]: CD22, CD30, C. Clin Microbiol Infect. 2018;24 Suppl 2:S83-S94 pubmed publisher
    ..To review, from an Infectious Diseases perspective, the safety profile of agents targeting CD22, CD30, CD33, CD38, CD40, SLAMF-7 and CCR4 and to suggest preventive recommendations...
  57. Paclet M, Berthier S, Kuhn L, Garin J, Morel F. Regulation of phagocyte NADPH oxidase activity: identification of two cytochrome b558 activation states. FASEB J. 2007;21:1244-55 pubmed
    Activation of the phagocyte NADPH oxidase (phox) requires the association of cytosolic proteins (p67-phox, p47-phox, p40-phox, and Rac1/2) with the membrane cytochrome b558, leading to a hemoprotein conformation change...
  58. Raponi S, De Propris M, Intoppa S, Milani M, Vitale A, Elia L, et al. Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: analysis of 552 cases. Leuk Lymphoma. 2011;52:1098-107 pubmed publisher
    ..series of cases of acute lymphoblastic leukemia (ALL) the expression of specific antigens, CD19, CD20, CD22, and CD33, for which MoAbs are available for clinical use...
  59. El Hawary R, Meshaal S, Deswarte C, Galal N, Abdelkawy M, Alkady R, et al. Role of Flow Cytometry in the Diagnosis of Chronic Granulomatous Disease: the Egyptian Experience. J Clin Immunol. 2016;36:610-8 pubmed publisher
    ..mutational defect in any of the NADPH oxidase complex, CYBB (gp91-phox), NCF1 (p47-phox), CYBA (p22-phox), NCF2 (p67-phox), or NCF4 (p40-phox) leading to inability of phagocytes to perform effective respiratory burst and thus ..
  60. Ding L, Hayes M, Photenhauer A, Eaton K, Li Q, Ocadiz Ruiz R, et al. Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia. J Clin Invest. 2016;126:2867-80 pubmed publisher
    ..patients, the human SLFN4 ortholog SLFN12L colocalized to cells that expressed MDSC surface markers CD15+CD33+HLA-DRlo...
  61. Laing A, Harrison C, Gibson B, Keeshan K. Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukemia. Exp Hematol. 2017;54:40-50 pubmed publisher
    ..The treatment of AML is challenging, and new strategies to target LSCs are required. The cell surface marker CD33 has been identified as a therapeutic target, and novel anti-CD33 immunotherapies are promising new agents in the ..
  62. Beaumel S, Picciocchi A, Debeurme F, Vivès C, Hesse A, Ferro M, et al. Down-regulation of NOX2 activity in phagocytes mediated by ATM-kinase dependent phosphorylation. Free Radic Biol Med. 2017;113:1-15 pubmed publisher
    ..had neither NADPH-oxidase nor reductase activity and exhibited abnormal translocation of p47phox and p67phox to the phagosomal membrane. This suggested a functional role of NIS...
  63. Fellner R, Cook A, O Connor P, Zhang S, Pollock D, Inscho E. High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism. Am J Physiol Renal Physiol. 2014;307:F33-40 pubmed publisher
    ..The increase in renal lipid peroxidation and p67(phox) expression induced by HS was prevented by apocynin treatment...
  64. Shen J, Huber M, Zhao E, Peng C, Li F, Li X, et al. Early rehabilitation aggravates brain damage after stroke via enhanced activation of nicotinamide adenine dinucleotide phosphate oxidase (NOX). Brain Res. 2016;1648:266-276 pubmed publisher
    ..exercise completion, and NOX activity and protein expression of NOX subunits (p47(phox), gp91(phox), p22(phox) and p67(phox)) and glucose transporter 1 and 3 (Glut-1 and -3) were measured at 3 and 24h after exercise...
  65. Lambert J, Morris C. Antibody-Drug Conjugates (ADCs) for Personalized Treatment of Solid Tumors: A Review. Adv Ther. 2017;34:1015-1035 pubmed publisher
    ..The first ADC to receive marketing authorization was gemtuzumab ozogamicin, which comprises an anti-CD33 antibody conjugated to a highly potent DNA-targeting antibiotic, calicheamicin, approved in 2000 for treating acute ..
  66. Chen L, Huang C, Li Y, Deng W, Mao L, Wu L, et al. Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma. Cell Mol Life Sci. 2018;75:2045-2058 pubmed publisher
    ..expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3...
  67. Sgroi D, Nocks A, Stamenkovic I. A single N-linked glycosylation site is implicated in the regulation of ligand recognition by the I-type lectins CD22 and CD33. J Biol Chem. 1996;271:18803-9 pubmed
    ..In contrast, mutation of a NCS motif in the first Ig domain of the I-type lectin CD33 unmasked its sialic acid binding activity...
  68. Liu Y, Yang M, Cao L, Huang Y, Xie M, Yang L, et al. [Painless skin nodules and ecchymosis in a school-aged girl]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17:1131-6 pubmed
    ..No abnormal cells have been found in bone marrow morphological examination, and bone marrow flow cytometry has shown that primitive precursor cells account for 1.5% and express CD33, CD34, CD123, and CD117.
  69. Zheng Y, Lin Y, Xu R, Zhou Y, Huang Y. [Analysis of Immunophenotypes in 329 Patients with B-ALL at Different Ages]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:1225-30 pubmed publisher
    ..B-ALL showed a higher concomitant expression rate of myeloid antigens CD13 and CD33; the CD11b, CD15, CD117 and T antigens (CD4, CD7 and CD56) were rarely expressed...
  70. Thankappan S, Rana R, Remesh A, Rekha V, Nagaleekar V, Puvvala B. Cloning and expression of P67 protein of Mycoplasma leachii. Vet World. 2017;10:1108-1113 pubmed publisher
    The present study was undertaken to clone, express and study the immunogenicity of P67 protein of Mycoplasma leachii.
  71. Jeong H, Lee H, Ko J, Cho B, Park S, Park J, et al. Myeloid-Derived Suppressor Cells Mediate Inflammation Resolution in Humans and Mice with Autoimmune Uveoretinitis. J Immunol. 2018;200:1306-1315 pubmed publisher
    ..In this article, we show that HLA-DR-CD11b+CD33+CD14+ human MDSCs and CD11b+Ly6G-Ly6C+ mouse MDSCs markedly ..
  72. Simmons D, Seed B. Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. J Immunol. 1988;141:2797-800 pubmed
    A cDNA clone encoding the human myeloid Ag CD33 was isolated from a U937 cDNA library after three rounds of transient expression in COS cells and enrichment by panning...
  73. Suvannasankha A, Minderman H, O Loughlin K, Nakanishi T, Greco W, Ross D, et al. Breast cancer resistance protein (BCRP/MXR/ABCG2) in acute myeloid leukemia: discordance between expression and function. Leukemia. 2004;18:1252-7 pubmed
    ..chain reaction and BCRP protein expression (BXP-21, BXP-34 or anti-ABCG2 antibody, with anti-CD34 and anti-CD33) and function (fumitremorgin C modulation of mitoxantrone retention) by flow cytometry in eight cell lines and in ..
  74. Marin V, Pizzitola I, Agostoni V, Attianese G, Finney H, Lawson A, et al. Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors. Haematologica. 2010;95:2144-52 pubmed publisher
    ..myeloid leukemia, we genetically modified cytokine-induced killer cells with chimeric receptors specific for the CD33 myeloid antigen...
  75. Pérez Oliva A, Martinez Esparza M, Vicente Fernández J, Corral San Miguel R, García Peñarrubia P, Hernández Caselles T. Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells. Glycobiology. 2011;21:757-70 pubmed publisher
    We have tested the usefulness of several commercial anti-CD33 monoclonal antibodies (mAb) to determine the expression and localization of the two CD33 isoforms on several hematopoietic cell lines...
  76. Souabni H, Ezzine A, Bizouarn T, Baciou L. Functional Assembly of Soluble and Membrane Recombinant Proteins of Mammalian NADPH Oxidase Complex. Methods Mol Biol. 2017;1635:27-43 pubmed publisher
    ..The other major proteins (p47phox, p67phox, p40phox, Rac) requisite for the complex activity are cytosolic proteins...
  77. Singh A, Sen E. Reciprocal role of SIRT6 and Hexokinase 2 in the regulation of autophagy driven monocyte differentiation. Exp Cell Res. 2017;360:365-374 pubmed publisher
    ..Notably, inhibition of autophagy increased HK2, diminished Chibby level and CD33 expression...
  78. Carvalheiro T, Horta S, van Roon J, Santiago M, Salvador M, Trindade H, et al. Increased frequencies of circulating CXCL10-, CXCL8- and CCL4-producing monocytes and Siglec-3-expressing myeloid dendritic cells in systemic sclerosis patients. Inflamm Res. 2018;67:169-177 pubmed publisher
    ..These data point towards a role of activated non-classical monocytes and mDCs producing enhanced levels of proinflammatory cytokines in SSc, potentially contributing to lung fibrosis. ..
  79. Handgretinger R, Schäfer H, Baur F, Frank D, Ottenlinger C, Buhring H, et al. Expression of an early myelopoietic antigen (CD33) on a subset of human umbilical cord blood-derived natural killer cells. Immunol Lett. 1993;37:223-8 pubmed
    ..This subset of CD56+/CD3- NK cells co-expressed the CD33 antigen, which is present on early hematopoietic progenitors confined to the myeloid lineage...
  80. Taylor V, Buckley C, Douglas M, Cody A, Simmons D, Freeman S. The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. J Biol Chem. 1999;274:11505-12 pubmed
    The myeloid restricted membrane glycoprotein, CD33, is a member of the recently characterized "sialic acid-binding immunoglobulin-related lectin" family...
  81. Balaian L, Ball E. Anti-CD33 monoclonal antibodies enhance the cytotoxic effects of cytosine arabinoside and idarubicin on acute myeloid leukemia cells through similarities in their signaling pathways. Exp Hematol. 2005;33:199-211 pubmed
    ..Ligation of the leukemia-associated antigen CD33 by anti-CD33 monoclonal antibody (mAb) also results in signaling events that induce a downregulation of cell growth...
  82. Malik M, Simpson J, Parikh I, Wilfred B, Fardo D, Nelson P, et al. CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing. J Neurosci. 2013;33:13320-5 pubmed publisher
    ..Here, we elucidate the mechanism of action of the AD-associated polymorphism rs3865444 in the promoter of CD33, a member of the sialic acid-binding Ig-superfamily of lectins (SIGLECs)...
  83. Ehninger A, Kramer M, Rollig C, Thiede C, Bornhauser M, von Bonin M, et al. Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia. Blood Cancer J. 2014;4:e218 pubmed publisher
    Owing to the more recent positive results with the anti-CD33 immunotoxin gemtuzumab ozogamicin, therapy against acute myeloid leukemias (AMLs) targeting CD33 holds many promises...
  84. Läubli H, Alisson Silva F, Stanczak M, Siddiqui S, Deng L, Verhagen A, et al. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. J Biol Chem. 2014;289:33481-91 pubmed publisher
    ..The CD33-related subset of sialic acid-binding immunoglobulin-like lectins (Siglecs) consists of immunomodulatory molecules ..
  85. Van Besien K, Koshy N, Gergis U, Mayer S, Cushing M, Rennert H, et al. Cord blood chimerism and relapse after haplo-cord transplantation. Leuk Lymphoma. 2017;58:288-297 pubmed
    ..Less than 20% UCB chimerism in the CD33 lineage was associated with an increased rate of disease recurrence (54% versus 11% p?<?0...
  86. Mitteldorf C, Berisha A, Pfaltz M, Broekaert S, Schön M, Kerl K, et al. Tumor Microenvironment and Checkpoint Molecules in Primary Cutaneous Diffuse Large B-Cell Lymphoma-New Therapeutic Targets. Am J Surg Pathol. 2017;41:998-1004 pubmed publisher
    ..tissue samples of pcDLBCL (13 leg type [LT], 3 others [OT]) were investigated for PD-1, PD-L1, and CD33 expression and the cellular composition of the tumor microenvironment, focusing on myeloid-derived suppressor cells ..
  87. Lamba J, Chauhan L, Shin M, Loken M, Pollard J, Wang Y, et al. CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children's Oncology Group Trial AAML0531. J Clin Oncol. 2017;35:2674-2682 pubmed publisher
    Purpose Gemtuzumab ozogamicin (GO), a CD33-targeted immunoconjugate, is a re-emerging therapy for acute myeloid leukemia (AML)...
  88. Laborda E, Mazagova M, Shao S, Wang X, Quirino H, Woods A, et al. Development of A Chimeric Antigen Receptor Targeting C-Type Lectin-Like Molecule-1 for Human Acute Myeloid Leukemia. Int J Mol Sci. 2017;18: pubmed publisher
    ..Conventional immunotherapy targets for AML such as CD33 and CD123 have been proposed as targets for chimeric antigen receptor (CAR)-engineered T-cells (CAR-T-cells), a ..
  89. Rush J, Laughlin M, Woodman C, Price E. SOD-1 expression in pig coronary arterioles is increased by exercise training. Am J Physiol Heart Circ Physiol. 2000;279:H2068-76 pubmed
    ..There were no effects of exercise training on the levels of SOD-2 (mitochondrial), catalase, or p67(phox) proteins...
  90. Vitale C, Romagnani C, Puccetti A, Olive D, Costello R, Chiossone L, et al. Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells. Proc Natl Acad Sci U S A. 2001;98:5764-9 pubmed
    ..recently identified inhibitory receptor expressed by natural killer and myeloid cells displaying high homology with CD33. Crosslinking of p75/AIRM-1 or CD33 has been shown to sharply inhibit the in vitro proliferation of both normal ..
  91. Mingari M, Vitale C, Romagnani C, Falco M, Moretta L. Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors. Adv Exp Med Biol. 2001;495:55-61 pubmed
  92. Bernstein I. CD33 as a target for selective ablation of acute myeloid leukemia. Clin Lymphoma. 2002;2 Suppl 1:S9-11 pubmed
    The CD33 antigen is a 67-kd glycosylated transmembrane protein of the sialic acid-binding immunoglobulinlike lectin (siglec) family with immunoreceptor tyrosine-based inhibitory motifs...