CD32

Summary

Gene Symbol: CD32
Description: Fc fragment of IgG receptor IIa
Alias: CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2, low affinity immunoglobulin gamma Fc region receptor II-a, Fc fragment of IgG, low affinity IIa, receptor (CD32), Immunoglobulin G Fc receptor II, fc-gamma-RIIa, fcRII-a, igG Fc receptor II-a
Species: human
Products:     CD32

Top Publications

  1. Maxwell K, Powell M, Hulett M, Barton P, McKenzie I, Garrett T, et al. Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa. Nat Struct Biol. 1999;6:437-42 pubmed
    ..In crystals, Fc gammaRIIa molecules associate to resemble V(L)V(H) dimers, suggesting that two Fc gammaRIIa molecules could cooperate to bind IgG in an asymmetric manner. ..
  2. Iwasaki M, Shimada N, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, et al. Fragment c gamma receptor gene polymorphisms and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Breast Cancer Res Treat. 2011;126:497-505 pubmed publisher
    ..We hypothesized that functional polymorphisms in fragment c gamma receptor (FcgR) genes were associated with breast cancer risk...
  3. Morgan A, Robinson J, Barrett J, Martin J, Walker A, Babbage S, et al. Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis. Arthritis Res Ther. 2006;8:R109 pubmed
    ..We have investigated the hypothesis that polymorphism within the FCGR genetic locus is associated with giant cell arteritis (GCA)...
  4. Hibbs M, Bonadonna L, Scott B, McKenzie I, Hogarth P. Molecular cloning of a human immunoglobulin G Fc receptor. Proc Natl Acad Sci U S A. 1988;85:2240-4 pubmed
    ..5 and 1.5 kilobases) that arise by use of different adenylylation signals. The cellular expression of these transcripts suggest that they encode the low-affinity p40 Fc gamma R protein. ..
  5. Ouma C, Keller C, Opondo D, Were T, Otieno R, Otieno M, et al. Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children. Am J Trop Med Hyg. 2006;74:573-7 pubmed
    ..Thus, although homozygosity for the R131 allele protects against high-density parasitemia, FcgammaRIIa-131 polymorphism does not protect against malaria anemia. ..
  6. Kyogoku C, Tsuchiya N, Matsuta K, Tokunaga K. Studies on the association of Fc gamma receptor IIA, IIB, IIIA and IIIB polymorphisms with rheumatoid arthritis in the Japanese: evidence for a genetic interaction between HLA-DRB1 and FCGR3A. Genes Immun. 2002;3:488-93 pubmed
    ..addition, the same groups of patients and controls were genotyped for HLA-DRB1 to examine possible interaction with FCGR genes...
  7. Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, et al. Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. Parasitol Int. 2002;51:361-6 pubmed
    ..Our results suggest that FcgammaRIIA-131H/R and FcgammaRIIIB-NA1/NA2 polymorphisms have an interactive effect on host defense against malaria infection. ..
  8. Weng W, Negrin R, Lavori P, Horning S. Immunoglobulin G Fc receptor FcgammaRIIIa 158 V/F polymorphism correlates with rituximab-induced neutropenia after autologous transplantation in patients with non-Hodgkin's lymphoma. J Clin Oncol. 2010;28:279-84 pubmed publisher
    ..This is a potential tool to identify a high-risk population for developing neutropenia after antibody therapy. ..
  9. Ghesquieres H, Cartron G, Seymour J, Delfau Larue M, Offner F, Soubeyran P, et al. Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms. Blood. 2012;120:2650-7 pubmed
    ..The PRIMA study is registered at www.clinicaltrials.gov as NCT00140582. ..

More Information

Publications63

  1. Ji Y, Zhang H, Lin S. [Single nucleotide polymorphism of FCGR2A gene in Han Chinese children with Kawasaki disease]. Zhongguo Dang Dai Er Ke Za Zhi. 2013;15:196-200 pubmed
    ..Polymorphism of the FCGR2A gene SNP rs1801274 is one of the important factors probably influencing susceptibility to KD and efficacy of IVIG therapy on KD in Han Chinese children. ..
  2. Qiu W, de Bruin D, Brownstein B, Pearse R, Ravetch J. Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. Science. 1990;248:732-5 pubmed
    ..Comparison of the human and mouse genes generated a model for the evolutionary amplification of this locus. ..
  3. Jönsson F, Mancardi D, Zhao W, Kita Y, Iannascoli B, Khun H, et al. Human Fc?RIIA induces anaphylactic and allergic reactions. Blood. 2012;119:2533-44 pubmed publisher
    ..Supporting these findings, human mast cells, monocytes and neutrophils produced anaphylactogenic mediators after Fc?RIIA engagement. IgG and Fc?RIIA may therefore contribute to allergic and anaphylactic reactions in humans. ..
  4. Wang B, Kokhaei P, Mellstedt H, Liljefors M. Fc?R polymorphisms and clinical outcome in colorectal cancer patients receiving passive or active antibody treatment. Int J Oncol. 2010;37:1599-606 pubmed
    ..Prospective extended clinical trials are warranted to study the predictive/prognostic impact of Fc?R polymorphisms in antibody-treated patients and might be a valuable biomarker to optimize antibody-based treatment strategies. ..
  5. Cherif M, Sanou G, Maiga B, Israelsson E, Ouédraogo A, Bougouma E, et al. Fc?RIIa polymorphism and anti-malaria-specific IgG and IgG subclass responses in populations differing in susceptibility to malaria in Burkina Faso. Scand J Immunol. 2012;75:606-13 pubmed publisher
    ..Fc?RIIa-R131H allele distribution is similar in both ethnic groups, and higher antibody levels are associated with the Fc?RIIa R allele compared to the H allele. ..
  6. Karakas M, Hoffmann M, Vollmert C, Rothenbacher D, Meisinger C, Winkelmann B, et al. Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations. BMC Med Genet. 2009;10:46 pubmed publisher
    The role of the Fc gamma receptor IIa (Fc gamma RIIa), a receptor for C-reactive protein (CRP), the classical acute phase protein, in atherosclerosis is not yet clear...
  7. Harley J, Alarcon Riquelme M, Criswell L, Jacob C, Kimberly R, Moser K, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008;40:204-10 pubmed publisher
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE. ..
  8. Zhang W, Gordon M, Schultheis A, Yang D, Nagashima F, Azuma M, et al. FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. J Clin Oncol. 2007;25:3712-8 pubmed
    ..Our preliminary data suggest that these two polymorphisms may be useful molecular markers to predict clinical outcome in metastatic CRC patients treated with cetuximab and that they may indicate a role of ADCC of cetuximab. ..
  9. Nasr A, Iriemenam N, Troye Blomberg M, Giha H, Balogun H, Osman O, et al. Fc gamma receptor IIa (CD32) polymorphism and antibody responses to asexual blood-stage antigens of Plasmodium falciparum malaria in Sudanese patients. Scand J Immunol. 2007;66:87-96 pubmed publisher
    ..Our results also revealed that the natural acquisition of immunity against clinical malaria appeared to be more associated with IgG1 and IgG3 antibodies, signifying their roles in parasite-neutralizing immune mechanisms. ..
  10. Hatjiharissi E, Hansen M, Santos D, Xu L, Leleu X, Dimmock E, et al. Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapy. Clin Lymphoma Myeloma. 2007;7:286-90 pubmed
    ..Knowledge of such linkages could facilitate the development of diagnostic tests aimed at identifying patients who might be more suitable for treatment with rituximab and possibly other therapeutic antibodies. ..
  11. Nasr A, Hamid O, Al Ghamdi A, Allam G. Anti-malarial IgG subclasses pattern and Fc?RIIa (CD32) polymorphism among pregnancy-associated malaria in semi-immune Saudi women. Malar J. 2013;12:110 pubmed publisher
    ..The individuals carrying H/H131 were consistently associated with higher levels of anti-malarial IgG subclasses. ..
  12. Brouwer K, Lal A, Mirel L, Otieno J, Ayisi J, Van Eijk A, et al. Polymorphism of Fc receptor IIa for immunoglobulin G is associated with placental malaria in HIV-1-positive women in western Kenya. J Infect Dis. 2004;190:1192-8 pubmed
    Genetic polymorphism of the Fc receptor IIa for immunoglobulin (Ig) G (Fc gamma RIIa) determines IgG subclass binding...
  13. Domingo P, Muñiz Diaz E, Baraldès M, Arilla M, Barquet N, Pericas R, et al. Associations between Fc gamma receptor IIA polymorphisms and the risk and prognosis of meningococcal disease. Am J Med. 2002;112:19-25 pubmed
    ..0001). The FcgammaRIIA-R/R131 allotype is associated with more severe forms of meningococcal disease. ..
  14. Cooke G, Aucan C, Walley A, Segal S, Greenwood B, Kwiatkowski D, et al. Association of Fcgamma receptor IIa (CD32) polymorphism with severe malaria in West Africa. Am J Trop Med Hyg. 2003;69:565-8 pubmed
    ..FcgammaRIIa (CD32) contains a polymorphic variant (H/R131) that has been associated with variability in susceptibility to both ..
  15. Chu Z, Tsuchiya N, Kyogoku C, Ohashi J, Qian Y, Xu S, et al. Association of Fcgamma receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations. Tissue Antigens. 2004;63:21-7 pubmed
    ..In this study, we analyzed the above four FCGR polymorphisms of the Chinese patients and controls for the association with SLE...
  16. Forthal D, Landucci G, Bream J, Jacobson L, Phan T, Montoya B. FcgammaRIIa genotype predicts progression of HIV infection. J Immunol. 2007;179:7916-23 pubmed
    ..These results demonstrate the importance of FcgammaRs in AIDS pathogenesis and point toward a critical role for interactions between FcgammaRs and immune complexes in disease progression. ..
  17. Dimou N, Nikolopoulos G, Hamodrakas S, Bagos P. Fcgamma receptor polymorphisms and their association with periodontal disease: a meta-analysis. J Clin Periodontol. 2010;37:255-65 pubmed publisher
    ..Further research, however, is needed in order to assess possible gene-gene or gene-environment interactions (i.e. with smoking). ..
  18. Schuldt K, Esser C, Evans J, May J, Timmann C, Ehmen C, et al. FCGR2A functional genetic variant associated with susceptibility to severe malarial anaemia in Ghanaian children. J Med Genet. 2010;47:471-5 pubmed publisher
    ..against the parasite is partially mediated through the Fc receptor for immunoglobulin (Ig) G IIa (FcgammaRIIa, CD32)...
  19. Endeman H, Cornips M, Grutters J, van den Bosch J, Ruven H, van Velzen Blad H, et al. The Fcgamma receptor IIA-R/R131 genotype is associated with severe sepsis in community-acquired pneumonia. Clin Vaccine Immunol. 2009;16:1087-90 pubmed publisher
    ..influenzae than in controls (OR, 3.03; CI, 1.04 to 9.09; P < 0.05). In conclusion, the Fcgamma-RIIa-R/R131 genotype is associated with severity of CAP and is more frequent in CAP caused by H. influenzae. ..
  20. Bibeau F, Lopez Crapez E, Di Fiore F, Thezenas S, Ychou M, Blanchard F, et al. Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J Clin Oncol. 2009;27:1122-9 pubmed publisher
    ..As these polymorphisms are also clinically relevant in mutated-KRAS mCRC, an important role of ADCC in cetuximab efficacy is presumed. ..
  21. Shi Y, Nahlen B, Kariuki S, Urdahl K, McElroy P, Roberts J, et al. Fcgamma receptor IIa (CD32) polymorphism is associated with protection of infants against high-density Plasmodium falciparum infection. VII. Asembo Bay Cohort Project. J Infect Dis. 2001;184:107-11 pubmed
    ..278; 95% confidence interval, 0.123-0.627; P=.0021). This finding supports the hypothesis. ..
  22. Nasr A, Elghazali G, Giha H, Troye Blomberg M, Berzins K. Interethnic differences in carriage of haemoglobin AS and Fcgamma receptor IIa (CD32) genotypes in children living in eastern Sudan. Acta Trop. 2008;105:191-5 pubmed
    ..We conclude that the H/H131 genotype and H131 allele rather than Hb AS genotype (sickle cell trait patients) appear to associate with the Fulani ethnic group. ..
  23. Gavasso S, Nygård O, Pedersen E, Aarseth J, Bleie O, Myhr K, et al. Fcgamma receptor IIIA polymorphism as a risk-factor for coronary artery disease. Atherosclerosis. 2005;180:277-82 pubmed
    ..Genetic variation in this IgG-receptor may influence the clearance of antibodies by monocyte-derived macrophages involved in the pathogenesis of CAD. ..
  24. Onouchi Y, Ozaki K, Burns J, Shimizu C, Terai M, Hamada H, et al. A genome-wide association study identifies three new risk loci for Kawasaki disease. Nat Genet. 2012;44:517-21 pubmed publisher
    ..6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease. ..
  25. Taniuchi S, Masuda M, Teraguchi M, Ikemoto Y, Komiyama Y, Takahashi H, et al. Polymorphism of Fc gamma RIIa may affect the efficacy of gamma-globulin therapy in Kawasaki disease. J Clin Immunol. 2005;25:309-13 pubmed
    ..HR and RR alleles may be a predictor of the progression of CALs in KD before the initiation of gamma-globulin therapy. ..
  26. Diamantopoulos P, Kalotychou V, Polonyfi K, Sofotasiou M, Anastasopoulou A, Galanopoulos A, et al. Correlation of Fc-γ RIIA polymorphisms with latent Epstein-Barr virus infection and latent membrane protein 1 expression in patients with low grade B-cell lymphomas. Leuk Lymphoma. 2013;54:2030-4 pubmed publisher
    Fc-γ RIIA (CD32), a member of the family of Fc-γ receptors, participates in the phagocytosis of bound to antibody antigens...
  27. Zakeri S, Mashhadi R, Mehrizi A, Djadid N. Analysis of Fcgamma receptor IIa (cd32) gene polymorphism and anti-malarial IgG subclass antibodies to asexual blood-stage antigen of Plasmodium falciparum in an unstable malaria endemic area of Iran. Exp Parasitol. 2013;134:115-21 pubmed publisher
    ..of the main host genetic factors involved in inflammation, immune responses and pathogenesis of malaria is Fc?RIIa (cd32) gene...
  28. Paez D, Paré L, Espinosa I, Salazar J, del Rio E, Barnadas A, et al. Immunoglobulin G fragment C receptor polymorphisms and KRAS mutations: are they useful biomarkers of clinical outcome in advanced colorectal cancer treated with anti-EGFR-based therapy?. Cancer Sci. 2010;101:2048-53 pubmed publisher
    ..To date, the EORTC (European Organization for Research and Treatment of Cancer Classification), skin toxicity, and KRAS status are the only reliable biomarkers to identify patients that would benefit from anti-EGFR therapy. ..
  29. Chen J, Dong J, Sun C, Bergeron A, McBride L, Pillai M, et al. Platelet FcgammaRIIA His131Arg polymorphism and platelet function: antibodies to platelet-bound fibrinogen induce platelet activation. J Thromb Haemost. 2003;1:355-62 pubmed
  30. Dijstelbloem H, Bijl M, Fijnheer R, Scheepers R, Oost W, Jansen M, et al. Fcgamma receptor polymorphisms in systemic lupus erythematosus: association with disease and in vivo clearance of immune complexes. Arthritis Rheum. 2000;43:2793-800 pubmed
    ..Notably, the R/H polymorphism of FcgammaRIIa affects the clearance of immune complexes in vivo, which may influence the course of a disease such as SLE. ..
  31. Karassa F, Trikalinos T, Ioannidis J. Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. Arthritis Rheum. 2002;46:1563-71 pubmed
    ..The FcgammaRIIa-R/H131 polymorphism represents a significant risk factor for SLE but has no clear effect on susceptibility for lupus nephritis. ..
  32. Graziano F, Ruzzo A, Loupakis F, Canestrari E, Santini D, Catalano V, et al. Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer. J Clin Oncol. 2008;26:1427-34 pubmed publisher
    ..7; P = .001) and treatment response (chi(2) test = 9.45; P = .008) than EGFR intron-1 L/L carriers. Although additional studies are required for confirmation, our findings could optimize the use of cetuximab in MCRC patients. ..
  33. Nasr A, Iriemenam N, Giha H, Balogun H, Anders R, Troye Blomberg M, et al. FcgammaRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups living in eastern Sudan. Malar J. 2009;8:43 pubmed publisher
    ..This study confirms and extends previous findings, analysing the FcgammaRIIa (CD32) polymorphism in relation to the IgG subclass distribution seen among two sympatric tribes living in eastern Sudan, ..
  34. Breunis W, van Mirre E, Geissler J, Laddach N, Wolbink G, van der Schoot E, et al. Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B. Hum Mutat. 2009;30:E640-50 pubmed publisher
    ..Next, we delineated the approximate boundaries of CNV at the FCGR locus...
  35. Dornan D, Spleiss O, Yeh R, Duchateau Nguyen G, Dufour A, Zhi J, et al. Effect of FCGR2A and FCGR3A variants on CLL outcome. Blood. 2010;116:4212-22 pubmed publisher
    ..42 CI]; P = .48, respectively). Overall, our results suggest that FCGR2A and FCGR3A polymorphisms do not significantly influence the outcomes of relapsed or refractory CLL patients treated with FC or the monoclonal antibody regimen R-FC. ..
  36. Stein M, Edberg J, Kimberly R, Mangan E, Bharadwaj D, Mold C, et al. C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific. J Clin Invest. 2000;105:369-76 pubmed
    ..This counterbalance may affect the contribution of FcgammaRIIA alleles to host defense and autoimmunity. ..
  37. Rodriguez J, Zarate R, Bandres E, Boni V, Hernández A, Sola J, et al. Fc gamma receptor polymorphisms as predictive markers of Cetuximab efficacy in epidermal growth factor receptor downstream-mutated metastatic colorectal cancer. Eur J Cancer. 2012;48:1774-80 pubmed publisher
    ..008). Fc?R polymorphisms may play a role in the clinical efficacy of Cetuximab in EGFR downstream mutated mCRC patients. Further research into Cetuximab immune-based mechanisms in KRAS-mutated patients seems warranted. ..
  38. Khor C, Davila S, Breunis W, Lee Y, Shimizu C, Wright V, et al. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet. 2011;43:1241-6 pubmed publisher
    ..The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease. ..
  39. Salmon J, Millard S, Schachter L, Arnett F, Ginzler E, Gourley M, et al. Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. J Clin Invest. 1996;97:1348-54 pubmed
    ..Human Fc gamma RIIa has two codominantly expressed alleles, R131 and H131, which differ substantially in their ability to ligate ..
  40. Kuwano S, Bordin J, Chiba A, Mello A, Figueiredo M, Vieira Filho J, et al. Allelic polymorphisms of human fcgamma receptor IIa and Fcgamma receptor IIIb among distinct groups in Brazil. Transfusion. 2000;40:1388-92 pubmed
    ..Moreover, the distribution of the FcgammaRIIA and FcgammaRIIIB alleles among Brazilian blood donors and SCD patients is comparable to the distributions reported in whites from the United States and Europe. ..
  41. Asano K, Matsushita T, Umeno J, Hosono N, Takahashi A, Kawaguchi T, et al. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nat Genet. 2009;41:1325-9 pubmed publisher
    ..Our findings provide insight into the molecular pathogenesis of ulcerative colitis. ..
  42. Brun J, Madland T, Vedeler C. Immunoglobulin G fc-receptor (FcgammaR) IIA, IIIA, and IIIB polymorphisms related to disease severity in rheumatoid arthritis. J Rheumatol. 2002;29:1135-40 pubmed
    ..Less effective processing of circulating immune complexes in RA patients homozygous for the FcgammaRIIA R allele may therefore contribute to a more unfavorable course. ..
  43. Israelsson E, Vafa M, Maiga B, Lysén A, Iriemenam N, Dolo A, et al. Differences in Fcgamma receptor IIa genotypes and IgG subclass pattern of anti-malarial antibodies between sympatric ethnic groups in Mali. Malar J. 2008;7:175 pubmed publisher
    ..Furthermore, the results indicate that the FcgammaRIIa R131H genotype may influence the IgG subclass responses related to protection against malaria, and that IgG2 may be of importance in this context. ..
  44. Sinha S, Mishra S, Sharma S, Patibandla P, Mallick P, Sharma S, et al. Polymorphisms of TNF-enhancer and gene for FcgammaRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population. Malar J. 2008;7:13 pubmed publisher
    ..The data emphasizes the need for addressing the contribution of human genetic factors in malaria in the context of disease epidemiology and population genetic substructure within India. ..
  45. van der Pol W, Jansen M, Sluiter W, van De Sluis B, Leppers van de Straat F, Kobayashi T, et al. Evidence for non-random distribution of Fcgamma receptor genotype combinations. Immunogenetics. 2003;55:240-6 pubmed
    ..00001). This study provides important information for the interpretation of studies reporting associations of FcgammaR alleles with disease, and underscores the apparent differences in FcgammaR heterogeneity between ethnic groups. ..
  46. Carlotti E, Palumbo G, Oldani E, Tibullo D, Salmoiraghi S, Rossi A, et al. FcgammaRIIIA and FcgammaRIIA polymorphisms do not predict clinical outcome of follicular non-Hodgkin's lymphoma patients treated with sequential CHOP and rituximab. Haematologica. 2007;92:1127-30 pubmed
    ..By contrast, the achievement of a durable molecular clearance of BCL2/IgH+ cells detectable in the bone marrow is confirmed to be a reliable predictive factor of a better long-term clinical outcome. ..
  47. Yuan F, Tanner J, Chan P, Biffin S, Dyer W, Geczy A, et al. Influence of FcgammaRIIA and MBL polymorphisms on severe acute respiratory syndrome. Tissue Antigens. 2005;66:291-6 pubmed
    ..The study reveals that in addition to age and co-morbidity, FcgammaRIIA polymorphism of individuals may also influence outcome after infection with the SARS-Cov. ..
  48. Huang Z, Chien P, Indik Z, Schreiber A. Human platelet Fc?RIIA and phagocytes in immune-complex clearance. Mol Immunol. 2011;48:691-6 pubmed publisher
    ..Human platelets, as a consequence of their expression of Fc?RIIA, may thus, contribute to the clearance of IgG-containing complexes from the circulation. ..
  49. Musolino A, Naldi N, Bortesi B, Pezzuolo D, Capelletti M, Missale G, et al. Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer. J Clin Oncol. 2008;26:1789-96 pubmed publisher
    ..antibody trastuzumab has been shown to engage both activatory (fragment C receptor [Fc gamma R]IIIa; Fc gamma RIIa) and inhibitory (Fc gamma RIIb) antibody receptors and Fc gamma R polymorphisms have been identified that may ..
  50. Wolf D, Neiderud A, Hinckley K, Dahlen G, van de Winkel J, Papapanou P. Fcgamma receptor polymorphisms and periodontal status: a prospective follow-up study. J Clin Periodontol. 2006;33:691-8 pubmed
    ..The present data failed to demonstrate a clinically relevant relationship between the Fcgamma receptor IIa (131R/H) or IIIb (NA1/NA2) polymorphism and periodontal status. ..
  51. Yamamoto K, Kobayashi T, Grossi S, Ho A, Genco R, Yoshie H, et al. Association of Fcgamma receptor IIa genotype with chronic periodontitis in Caucasians. J Periodontol. 2004;75:517-22 pubmed
    ..Further studies with families and studies of mechanisms are necessary to help establish the extent to which this is a genetic determinant of periodontal diseases. ..
  52. Chen J, Wang C, Wu J, Ho H, Luo S. Association of rheumatoid factor production with FcgammaRIIIa polymorphism in Taiwanese rheumatoid arthritis. Clin Exp Immunol. 2006;144:10-6 pubmed
    ..The results of this study suggest that three activating FcgammaRs polymorphisms lack association with RA but FcgammaIIIa F/V158 polymorphism may influence RF production and IgG RF immune complex handling in Taiwanese RA patients. ..
  53. van der Meer I, Witteman J, Hofman A, Kluft C, de Maat M. Genetic variation in Fcgamma receptor IIa protects against advanced peripheral atherosclerosis. The Rotterdam Study. Thromb Haemost. 2004;92:1273-6 pubmed
    ..52 (0.29-0.93) and 0.45 (0.23-0.86), for heterozygotes and H131 homozygotes, respectively; P trend=0.02). This is the first study showing that the H131 allele of FcgammaRIIa protects against advanced peripheral atherosclerosis. ..
  54. Weng W, Czerwinski D, Timmerman J, Hsu F, Levy R. Clinical outcome of lymphoma patients after idiotype vaccination is correlated with humoral immune response and immunoglobulin G Fc receptor genotype. J Clin Oncol. 2004;22:4717-24 pubmed
    ..Our results imply that the antibodies induced against a tumor antigen are beneficial and that FcgammaR-bearing cells mediate an antitumor effect by killing antibody-coated tumor cells. ..