CD3

Summary

Gene Symbol: CD3
Description: CD3d molecule
Alias: CD3-DELTA, IMD19, T3D, T-cell surface glycoprotein CD3 delta chain, CD3 antigen, delta subunit, CD3 delta, CD3d antigen, delta polypeptide (TiT3 complex), CD3d molecule, delta (CD3-TCR complex), OKT3, delta chain, T-cell receptor T3 delta chain
Species: human
Products:     CD3

Top Publications

  1. Fernández Malavé E, Wang N, Pulgar M, Schamel W, Alarcon B, Terhorst C. Overlapping functions of human CD3delta and mouse CD3gamma in alphabeta T-cell development revealed in a humanized CD3gamma-mouse. Blood. 2006;108:3420-7 pubmed
    ..Taken together, these data demonstrate that CD3delta and CD3gamma play a different role in humans and mice in pre-TCR and TCR function during alphabeta T-cell development. ..
  2. Ruegg C, Strand M. A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx. Cell Immunol. 1991;137:1-13 pubmed
    ..HIV-1 gp41 peptide aa581-597 inhibits lymphoproliferation stimulated via the distinct T-cell-activation molecules CD3, CD2, and CD28, as well as direct stimulation mediated by phorbol ester combined with ionomycin...
  3. Koning F, Maloy W, Coligan J. The implications of subunit interactions for the structure of the T cell receptor-CD3 complex. Eur J Immunol. 1990;20:299-305 pubmed
    Cell surface-expressed receptors are often multichain complexes. One of these, the T cell receptor (TcR) alpha/beta-CD3 complex, is known to contain at least seven chains: the alpha and beta TcR chains plus the gamma, delta, epsilon and ..
  4. Dadi H, Simon A, Roifman C. Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency. N Engl J Med. 2003;349:1821-8 pubmed
  5. De Saint Basile G, Geissmann F, Flori E, Uring Lambert B, Soudais C, Cavazzana Calvo M, et al. Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3. J Clin Invest. 2004;114:1512-7 pubmed
    ..haplotypes within the 11q23 region, in which the genes encoding the gamma, delta, and epsilon subunits of CD3 are located...
  6. Schindler M, Munch J, Kutsch O, Li H, Santiago M, Bibollet Ruche F, et al. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell. 2006;125:1055-67 pubmed
    ..Here, we report that nef alleles from the great majority of primate lentiviruses, including HIV-2, downmodulate TCR-CD3 from infected T cells, thereby blocking their responsiveness to activation...
  7. Ballar P, Zhong Y, Nagahama M, Tagaya M, Shen Y, Fang S. Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation. J Biol Chem. 2007;282:33908-14 pubmed
    ..These results suggest that SVIP is an endogenous inhibitor of ERAD that acts through regulating the assembly of the gp78-p97/VCP-Derlin1 complex. ..
  8. Siegers G, Swamy M, Fernández Malavé E, Minguet S, Rathmann S, Guardo A, et al. Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies. J Exp Med. 2007;204:2537-44 pubmed
    The gammadelta T cell receptor for antigen (TCR) comprises the clonotypic TCRgammadelta, the CD3 (CD3gammaepsilon and/or CD3deltaepsilon), and the zetazeta dimers...
  9. Ariën K, Verhasselt B. HIV Nef: role in pathogenesis and viral fitness. Curr HIV Res. 2008;6:200-8 pubmed
    ..Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness. ..

More Information

Publications122 found, 100 shown here

  1. Malim M, Emerman M. HIV-1 accessory proteins--ensuring viral survival in a hostile environment. Cell Host Microbe. 2008;3:388-98 pubmed publisher
    ..Broadly speaking, the HIV-1 accessory proteins modify the local environment within infected cells to ensure viral persistence, replication, dissemination, and transmission. ..
  2. Kim S, Touma M, Takeuchi K, Sun Z, Dave V, Kappes D, et al. Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors. J Immunol. 2010;185:2951-9 pubmed publisher
    ..TCRbeta and CD3 subunit protein sequence analyses among Gnathostomata species show that the Cbeta FG loop and CD3gamma subunit ..
  3. Gil J, Busto E, Garcillán B, Chean C, García Rodríguez M, Díaz Alderete A, et al. A leaky mutation in CD3D differentially affects ?? and ?? T cells and leads to a T??-T??+B+NK+ human SCID. J Clin Invest. 2011;121:3872-6 pubmed publisher
    ..Both ?? and ?? TCRs also contain several invariant chains, including CD3?, which support surface TCR expression and transduce the TCR signal...
  4. Manolios N, Kemp O, Li Z. The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains. Eur J Immunol. 1994;24:84-92 pubmed
    Selective pairwise interactions between CD3 chains and the clonotypic T cell antigen receptor (TCR)-alpha, -beta chains has recently been established...
  5. Arnett K, Harrison S, Wiley D. Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. Proc Natl Acad Sci U S A. 2004;101:16268-73 pubmed
    ..signals from MHC/peptide antigens through a set of constitutively associated signaling molecules, including CD3-epsilon/gamma and CD3-epsilon/delta. We report the crystal structure at 1...
  6. Munch J, Rajan D, Schindler M, Specht A, Rücker E, Novembre F, et al. Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses. J Virol. 2007;81:13852-64 pubmed
    ..highly conserved between most or all primate lentiviruses, whereas Nef-mediated downregulation of T-cell receptor-CD3 was lost in the lineage that gave rise to human immunodeficiency virus type 1 (HIV-1)...
  7. Luzzati A, Pugliese O, Giacomini E, Giordani L, Quintieri F, Hraba T, et al. Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV. Folia Biol (Praha). 1990;36:71-7 pubmed
    ..These findings may help to unravel some of the pathogenic mechanisms of AIDS and may contribute to the development of vaccine strategies. ..
  8. Khaled Y, Wright K, Melcher A, Jayne D. Anti-cancer effects of oncolytic viral therapy combined with photodynamic therapy in human pancreatic cancer cell lines. Lancet. 2015;385 Suppl 1:S56 pubmed publisher
    ..and BXPC-3) and a non-cancer control cell line (HEK293) were infected with reovirus serotype 3 strain Dearing (T3D) at 0, 0·1, 1, and 10 plaque-forming units (PFU) per cell for 48 h...
  9. Sigalov A, AIVAZIAN D, Uversky V, Stern L. Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits. Biochemistry. 2006;45:15731-9 pubmed
    ..The implications of these results for transmembrane signal transduction by immune receptors are discussed. ..
  10. Giacomini E, Giordani L, Di Modugno F, Chersi A, Luzzati A. Increased PGE2 production mediates the in vitro inhibitory effect of the human immunodeficiency virus P24 immunosuppressive heptapeptide Ch7. Scand J Immunol. 1998;48:248-53 pubmed
  11. Birnbaum M, Berry R, Hsiao Y, Chen Z, Shingu Vazquez M, Yu X, et al. Molecular architecture of the αβ T cell receptor-CD3 complex. Proc Natl Acad Sci U S A. 2014;111:17576-81 pubmed publisher
    ..Instead, the TCR is noncovalently coupled to a conserved multisubunit signaling apparatus, the CD3 complex, that comprises the CD3εγ, CD3εδ, and CD3ζζ dimers...
  12. Ezzati P, Komher K, Severini G, Coombs K. Comparative proteomic analyses demonstrate enhanced interferon and STAT-1 activation in reovirus T3D-infected HeLa cells. Front Cell Infect Microbiol. 2015;5:30 pubmed publisher
    ..We recently described comparative stable isotopic (SILAC) analyses of reovirus, strain type 3 Dearing (T3D)-infected HeLa cells...
  13. Limbach M, Saare M, Tserel L, Kisand K, Eglit T, Sauer S, et al. Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling. J Autoimmun. 2016;67:46-56 pubmed publisher
    ..involved in T cell signaling (CD247, LCK, ZAP70, CD3D, CD3E, CD3G, CTLA4 and CD8A) and decreased expression of CD3 gene family members...
  14. Liang C, Peng L, Zeng S, Zhao Q, Tang L, Jiang X, et al. Investigation of indoleamine 2,3-dioxygenase 1 expression in uveal melanoma. Exp Eye Res. 2019;181:112-119 pubmed publisher
    ..BM rupture is an important indicator of IDO1 expression level and distribution pattern. The complex role of IDO1 may limit its therapeutic effect in UM. ..
  15. Oh Y, Jo N, Park J, Gye M. Changes in Inflammatory Cytokines Accompany Deregulation of Claudin-11, Resulting in Inter-Sertoli Tight Junctions in Varicocele Rat Testes. J Urol. 2016;196:1303-12 pubmed publisher
  16. van Leeuwen J, Kearse K. Calnexin associates exclusively with individual CD3 delta and T cell antigen receptor (TCR) alpha proteins containing incompletely trimmed glycans that are not assembled into multisubunit TCR complexes. J Biol Chem. 1996;271:9660-5 pubmed
    ..we studied the role of glucose (Glc) trimming and calnexin association in the oligomerization of TCR alpha and CD3 delta glycoproteins in murine splenic T lymphocytes, a model cell type for efficient assembly of complete TCR ..
  17. Lino Silva L, Loaeza Belmont R, Gómez Álvarez M, Vela Sarmiento I, Aguilar Romero J, Domínguez Rodríguez J, et al. Mesorectal Invasion Depth in Rectal Carcinoma Is Associated With Low Survival. Clin Colorectal Cancer. 2017;16:73-77 pubmed publisher
    ..The patients were grouped by MED (T3a, < 1 mm; T3b, 1-5 mm; T3c > 5-10 mm; and T3d > 10 mm). The clinicopathologic data and disease-free survival were analyzed...
  18. Dietrich M, Ogden K, Long J, Ebenhoch R, Thor A, Dermody T, et al. Structural and Functional Features of the Reovirus σ1 Tail. J Virol. 2018;92: pubmed publisher
    ..and properties, we determined high-resolution structures of the reovirus type 1 Lang (T1L) and type 3 Dearing (T3D) σ1 tail domains...
  19. Chan A, van Oers N, Tran A, Turka L, Law C, Ryan J, et al. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994;152:4758-66 pubmed
    ..Thus, the differential expression of these kinases suggests the possibility of different roles for ZAP-70 and Syk in TCR signaling and thymic development. ..
  20. Ma D, Zhong S, Liu X, Mai H, Mai G, Xu C, et al. CD3D and PRKCQ work together to discriminate between B-cell and T-cell acute lymphoblastic leukemia. Comput Biol Med. 2016;77:16-22 pubmed publisher
    ..Supplementary material is available at http://healthinformaticslab.org/supp/. ..
  21. Rivera Serrano E, Fritch E, Scholl E, Sherry B. A Cytoplasmic RNA Virus Alters the Function of the Cell Splicing Protein SRSF2. J Virol. 2017;91: pubmed publisher
    ..We previously reported that the reovirus protein μ2 from strain T1L, but not strain T3D, represses one antiviral response: alpha/beta interferon signaling...
  22. Dianzani U, Bragardo M, Buonfiglio D, Redoglia V, Funaro A, Portoles P, et al. Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120. Eur J Immunol. 1995;25:1306-11 pubmed
    ..In the absence of gp120, CD4 displayed high association with CD3, CD5, CD45RC, CD25, CD28, CD44, and CD53; weak association with CD2, CD38, CD45RB, CD62L, and CD26; and no ..
  23. Almansa R, Heredia Rodríguez M, Gomez Sanchez E, Andaluz Ojeda D, Iglesias V, Rico L, et al. Transcriptomic correlates of organ failure extent in sepsis. J Infect. 2015;70:445-56 pubmed publisher
    ..Quantification of the expression levels of the genes identified here could contribute to the simultaneous assessment of disease severity and immunological alterations in sepsis. ..
  24. Rowe J, Delmonte O, Keles S, Stadinski B, Dobbs A, Henderson L, et al. Patients with CD3G mutations reveal a role for human CD3γ in Treg diversity and suppressive function. Blood. 2018;: pubmed publisher
    Integrity of the T cell receptor/CD3 (TCR/CD3) complex is crucial for positive and negative selection of T cells in the thymus, and for effector and regulatory functions of peripheral T lymphocytes...
  25. Van de Walle I, De Smet G, De Smedt M, Vandekerckhove B, Leclercq G, Plum J, et al. An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells. Blood. 2009;113:2988-98 pubmed publisher
    ..Our results reveal stage-dependent molecular changes in Notch signaling that are critical for normal human T-cell development and reveal fundamental molecular differences between mouse and human. ..
  26. Kemp V, Dautzenberg I, Cramer S, Hoeben R, van den Wollenberg D. Characterization of a replicating expanded tropism oncolytic reovirus carrying the adenovirus E4orf4 gene. Gene Ther. 2018;25:331-344 pubmed publisher
    While the mammalian orthoreovirus type 3 dearing (reovirus T3D) infects many different tumour cells, various cell lines resist the induction of reovirus-mediated cell death...
  27. Leonard B, Starrett G, Maurer M, Oberg A, Van Bockstal M, Van Dorpe J, et al. APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma. Clin Cancer Res. 2016;22:4746-55 pubmed publisher
    ..Immunoimaging was used to colocalize APOBEC3G and the T-cell marker CD3. TCGA data extended expression analyses to additional cancer types...
  28. Thete D, Snyder A, Mainou B, Danthi P. Reovirus ?1 Protein Affects Infectivity by Altering Virus-Receptor Interactions. J Virol. 2016;90:10951-10962 pubmed publisher
    ..We demonstrate that a reassortant virus that expresses the M2 gene-encoded ?1 protein derived from prototype strain T3D in an otherwise prototype T1L background (T1L/T3DM2) infects cells more efficiently than parental T1L...
  29. Lim P, Danner R, Liang J, Doong H, Harman C, Srinivasan D, et al. Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J Cell Biol. 2009;187:201-17 pubmed publisher
    ..Our results strongly support a role for this complex in ERAD and in the regulation of ER stress. ..
  30. Li X, Peng J, Pang Y, Yu S, Yu X, Chen P, et al. Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma. Sci Rep. 2015;5:14757 pubmed publisher
    The liver resident lymphoid population is featured by the presence of a large number of CD3(+)CD56(+) cells referred as natural T cells...
  31. Usui M, Fujikawa T, Osawa M, Hakii C, Ikumi N, Nozaki T, et al. Self-assembly formed by a short DNA probe pair: Application for highly sensitive mRNA species detection without reverse transcription. Biochem Biophys Res Commun. 2015;467:1012-8 pubmed publisher
    ..Moreover, multiple mRNAs could be detected simultaneously in a single reaction tube and there was a good correlation between the results obtained PALSAR and those by real-time PCR. ..
  32. van den Elsen P, Shepley B, Cho M, Terhorst C. Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein. Nature. 1985;314:542-4 pubmed
    ..Our sequence data strongly suggest that this mouse mRNA codes for a complete T3 delta polypeptide chain and reveal some interesting properties of the protein. ..
  33. Pace M, Graf E, Agosto L, Mexas A, Male F, Brady T, et al. Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency. PLoS Pathog. 2012;8:e1002818 pubmed publisher
    ..The defect was reversed upon stimulation with IL-7 or CD3/28 beads. Thus, a population of latent cells can produce viral proteins without resulting in spreading infection...
  34. Hori T, de Waal Malefyt R, Duncan B, Harrison M, Roncarolo M, Spits H. Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3. Int Immunol. 1991;3:353-7 pubmed
    ..Both clones were found to express cytoplasmic CD3 delta and CD3 epsilon Ag while CD3- NK clones isolated from PBL were negative for them...
  35. Sigalov A, Aivazian D, Stern L. Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif. Biochemistry. 2004;43:2049-61 pubmed
    ..Phosphorylation of zeta(cyt) and FcepsilonRIgamma(cyt) does not significantly alter their oligomerization behavior. The implications of these results for transmembrane signaling and cellular activation by immune receptors are discussed. ..
  36. Brown J, Short S, Stencel Baerenwald J, Urbanek K, Pruijssers A, McAllister N, et al. Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection. J Virol. 2018;92: pubmed publisher
    ..strain T1L, which induces an inflammatory immune response to fed antigen, is prolonged in the intestine, whereas T3D-RV, which does not induce this response, is rapidly cleared from the intestine...
  37. Alexander D, Goris J, Marais R, Rothbard J, Merlevede W, Crumpton M. Dephosphorylation of the human T lymphocyte CD3 antigen. Eur J Biochem. 1989;181:55-65 pubmed
    ..that activation of T lymphocytes by phorbol ester or mitogenic lectin leads to phosphorylation of Ser 126 of the CD3 antigen gamma chain, whereas treatment with ionomycin results in phosphorylation of both Ser 123 and 126 [Davies, A...
  38. Tunnacliffe A, Buluwela L, Rabbitts T. Physical linkage of three CD3 genes on human chromosome 11. EMBO J. 1987;6:2953-7 pubmed
    ..The genes for CD3 gamma and CD3 delta are situated close together, about 1.6 kb apart, organized in a head-to-head orientation...
  39. Balk S, Polischuk J, Probert C, Stevens C, Ebert E, She J, et al. Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain. Int Immunol. 1995;7:1237-41 pubmed
    ..One- and two-dimensional non-reducing/reducing SDS-PAGE analysis of CD3 gamma, CD3 delta, CD3 epsilon, zeta and Fc epsilon RI gamma chain immunoprecipitates of cell surface radiolabeled proteins with ..
  40. Thete D, Danthi P. Protein Mismatches Caused by Reassortment Influence Functions of the Reovirus Capsid. J Virol. 2018;92: pubmed publisher
    ..We characterized the properties of T3DF/T3DCS1, an S1 gene monoreassortant between two laboratory isolates of prototype reovirus ..
  41. Fang S, Ferrone M, Yang C, Jensen J, Tiwari S, Weissman A. The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2001;98:14422-7 pubmed
    ..Importantly, gp78 can also mediate degradation of CD3-delta, a well-characterized ERAD substrate...
  42. Markle T, Philip M, Brockman M. HIV-1 Nef and T-cell activation: a history of contradictions. Future Virol. 2013;8: pubmed publisher
  43. Kako H, Krishna S, Sebastian R, Smith K, Tobias J. Effect of dexmedetomidine on the QT interval in pediatric patients undergoing general anesthesia. J Anesth. 2015;29:862-7 pubmed publisher
    ..2 min after the administration of dexmedetomidine, which in turn was started immediately after the T2 ECG reading (T3D); in group C, it was obtained 2 min after the T2 reading (T3C)...
  44. Okada H, Momota H, Okada N, Okamoto T, Azuma T. Elimination of HIV-infected cells by lymphocytes armed with a bifunctional antibody to gp120 of HIV and CD3. Immunol Lett. 1993;38:195-9 pubmed
    ..Lymphocytes armed with BFA directed to CD3 and an HIV antigen were able to eliminate all HIV antigen-positive cells during incubation with a mixture of HIV-..
  45. Banning C, Votteler J, Hoffmann D, Koppensteiner H, Warmer M, Reimer R, et al. A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells. PLoS ONE. 2010;5:e9344 pubmed publisher
  46. Mabuchi T, Takekoshi T, Hwang S. Epidermal CCR6+ ?? T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis. J Immunol. 2011;187:5026-31 pubmed publisher
    ..Our data suggest that a subset of ?? T cells play a critical role in IL-23-mediated psoriasiform dermatitis. ..
  47. Li B, Liu S, Niu Y, Fang S, Wu X, Yu Z, et al. Altered expression of the TCR signaling related genes CD3 and Fc?RI? in patients with aplastic anemia. J Hematol Oncol. 2012;5:6 pubmed publisher
    ..To elucidate the T cell receptor (TCR) signal transduction features in AA, the expression levels of CD3?, ?, ? and ? chain and Fc?RI? genes, which are involved in TCR signal transduction, and the negative correlation of ..
  48. Simon E, Howells M, Stuart J, Boehme K. Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus. Viruses. 2017;9: pubmed publisher
    ..Here, we tested the oncolytic capacity of recombinant strains (rs) of prototype reovirus laboratory strains T1L and T3D (rsT1L and rsT3D, respectively) in a panel of non-small cell lung cancer (NSCLC) cell lines...
  49. Luzzati A, Giacomini E, Giordani L, Pugliese O, Viora M, Chersi A. The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope. Immunol Lett. 1992;33:307-14 pubmed
    ..Moreover, they are of potential relevance for the development of immunoprophylactic and therapeutic strategies. ..
  50. Ko L, Yamamoto M, Leonard M, George K, Ting P, Engel J. Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol Cell Biol. 1991;11:2778-84 pubmed
    ..We infer that the murine and human GATA-3 proteins play a central and highly conserved role in vertebrate T-cell-specific transcriptional regulation. ..
  51. San José E, Sahuquillo A, Bragado R, Alarcon B. Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model. Eur J Immunol. 1998;28:12-21 pubmed
    ..a series of pairwise interactions involving the formation of dimers of CD3 epsilon with either CD3 gamma or CD3 delta. These dimers assemble with TCR alpha and TCR beta chains, and finally, the CD3 zeta homodimer is added to allow ..
  52. Tong M, Deochand C, DIDSBURY J, de la Monte S. T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer's Disease. J Alzheimers Dis. 2016;51:123-38 pubmed publisher
    b>T3D-959, a dual PPAR-δ/PPAR γ nuclear receptor agonist and former diabetes drug candidate, has been repositioned as an Alzheimer's disease (AD)-modifying therapy...
  53. Zekri A, El Sisi E, Abdallah Z, Ismail A, Barakat Barakat A. Gene expression profiling of circulating CD133+ cells of hepatocellular carcinoma patients associated with HCV infection. J Egypt Natl Canc Inst. 2017;29:19-24 pubmed publisher
    ..012). KRT15 can be used to differentiate between circulating CD133+ cells from HCC group and control group. However, further study may be needed to confirm on the protein level. ..
  54. Szymczak A, Vignali D. Plasticity and rigidity in adaptor protein-2-mediated internalization of the TCR:CD3 complex. J Immunol. 2005;174:4153-60 pubmed
    ..we have examined how AP-2 mediates internalization of large cell surface receptors, such as the eight-chain TCR:CD3 complex...
  55. Rudolph J, Eickel N, Haller C, Schindler M, Fackler O. Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins. J Virol. 2009;83:11528-39 pubmed publisher
    ..of the immunological synapse (IS) such as relocalization of the Lck kinase, as well as early inhibition of TCR/CD3 complex (TCR-CD3)-mediated actin rearrangements and tyrosine phosphorylation...
  56. Klintman M, Buus R, Cheang M, Sheri A, Smith I, Dowsett M. Changes in Expression of Genes Representing Key Biologic Processes after Neoadjuvant Chemotherapy in Breast Cancer, and Prognostic Implications in Residual Disease. Clin Cancer Res. 2016;22:2405-16 pubmed publisher
    ..The multivariable gene models identified could, if validated, be used to identify patients needing additional post-neoadjuvant treatment to improve prognosis. Clin Cancer Res; 22(10); 2405-16. ©2016 AACR. ..
  57. de la Monte S, Tong M, Schiano I, DIDSBURY J. Improved Brain Insulin/IGF Signaling and Reduced Neuroinflammation with T3D-959 in an Experimental Model of Sporadic Alzheimer's Disease. J Alzheimers Dis. 2017;55:849-864 pubmed
    ..The intracerebral streptozotocin (i.c. STZ) model replicates the full range of abnormalities in sporadic AD. T3D-959, an orally active PPAR-delta/gamma agonist remediates neurocognitive deficits and AD neuropathology in the i.c...
  58. Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G. Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. J Clin Invest. 1990;86:2117-24 pubmed
    The interference of the recombinant HIV-1 glycoproteins gp160 and gp120 with the CD3/T cell antigen receptor (TcR)-mediated activation process has been investigated in the CD4+ diphtheria toxoid-specific human P28D T cell clone...
  59. Chen B, Mariano J, Tsai Y, Chan A, Cohen M, Weissman A. The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. Proc Natl Acad Sci U S A. 2006;103:341-6 pubmed
    ..These results also provide proof of principle that interrupting a specific E2-E3 interaction can selectively inhibit ERAD. ..
  60. Pan Q, Brodeur J, Drbal K, Dave V. Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function: human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice. Mol Immunol. 2006;43:1741-50 pubmed
    ..b>CD3 chains are present as CD3gammaepsilon, deltaepsilon, and zetazeta dimers in the receptor complex and play critical ..
  61. Lee S, Cho K, Cho S, Kim I, Oh C, Ahn K. Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation. EMBO J. 2010;29:363-75 pubmed publisher
    ..Together, our data suggest that PDI is a component of the SPP-mediated ER-associated degradation machinery. ..
  62. Phillips J, Hori T, Nagler A, Bhat N, Spits H, Lanier L. Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins. J Exp Med. 1992;175:1055-66 pubmed
    ..and clones derived from these cells, as well as a subset of cord blood NK cells, express substantial levels of CD3 delta and CD3 epsilon proteins in the cytoplasm...
  63. Luzzati A, Giacomini E, Giordani L, Viora M, Chersi A, Camponeschi B, et al. An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex. Cell Immunol. 1994;156:286-95 pubmed
    ..Finally, Ch7 inhibited anti-CD3-induced lymphoproliferation but did not affect anti-CD2 activation...
  64. Hiller B, Berger A, Danthi P. Viral gene expression potentiates reovirus-induced necrosis. Virology. 2015;484:386-94 pubmed publisher
    ..While reovirus strain T3D induces necrosis much more efficiently than strain T1L, which viral components contribute to this difference is not ..
  65. Berard A, Severini A, Coombs K. Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion. J Virol. 2015;89:11954-64 pubmed publisher
    ..We recently performed global proteomic screens of mammalian reovirus TIL- and T3D-infected and herpesvirus (herpes simplex virus 1 [HSV-1])-infected HEK293 cells...
  66. Lanoie D, Lemay G. Multiple proteins differing between laboratory stocks of mammalian orthoreoviruses affect both virus sensitivity to interferon and induction of interferon production during infection. Virus Res. 2018;247:40-46 pubmed publisher
    In the course of previous works, it was observed that the virus laboratory stock (T3DS) differs in sequence from the virus encoded by the ten plasmids currently in use in many laboratories (T3DK), and derived from a ..
  67. van den Elsen P, Georgopoulos K, Shepley B, Orkin S, Terhorst C. Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex. Proc Natl Acad Sci U S A. 1986;83:2944-8 pubmed
    ..The T3-delta gene does not contain the "TATA box" found in many eukaryotic promoters. ..
  68. Ott M, Lovett J, Mueller L, Verdin E. Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors. J Immunol. 1998;160:2872-80 pubmed
    ..The HIV-1 transactivator protein Tat increased IL-8 secretion in T cell lines following CD3- and CD28-mediated costimulation...
  69. Cornfield D, Gheith S. Flow cytometric quantitation of natural killer cells and T lymphocytes expressing T-cell receptors alpha/beta and gamma/delta is not helpful in distinguishing benign from malignant body cavity effusions. Cytometry B Clin Cytom. 2009;76:213-7 pubmed publisher
    ..Values for the two T-lymphocyte subsets in human effusions are, to our knowledge, established for the first time by flow cytometric determination. ..
  70. Locke M, Toth J, Petroski M. Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation. Biochem J. 2014;459:205-16 pubmed publisher
    ..In addition to general effects on p97-associated ubiquitin polymers, the ERAD substrate CD3δ is modified with both Lys11 and Lys48 ubiquitin chains prior to p97-dependent dislocation...
  71. Pasman Y, Merico D, Kaushik A. Preferential expression of IGHV and IGHD encoding antibodies with exceptionally long CDR3H and a rapid global shift in transcriptome characterizes development of bovine neonatal immunity. Dev Comp Immunol. 2017;67:495-507 pubmed publisher
    ..The transcriptome signatures described here permit assessment bovine neonatal immunocompetence. Bovine neonates acquire innate and IgM-mediated humoral immunocompetence within first week post-birth. ..
  72. Gold D, Clevers H, Alarcon B, Dunlap S, Novotny J, Williams A, et al. Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. Proc Natl Acad Sci U S A. 1987;84:7649-53 pubmed
    ..surface of the thymus-derived (T) lymphocytes are associated with small integral membrane proteins called the T3 (CD3) gamma, delta, epsilon, and zeta chains...
  73. Tunnacliffe A, Sims J, Rabbitts T. T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells. EMBO J. 1986;5:1245-52 pubmed
    ..A putative protein, produced by translation of the shorter mRNA, would lack a transmembrane region and might be secreted or associated with the outer surface of the cell. ..
  74. Kearse K, Roberts J, Singer A. TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes. Immunity. 1995;2:391-9 pubmed
    ..We demonstrate that TCR assembly proceeds by initial association of TCR alpha with CD3 delta epsilon proteins and by association of TCR beta with CD3 gamma epsilon proteins to form alpha delta epsilon and ..
  75. Ott M, Emiliani S, Van Lint C, Herbein G, Lovett J, Chirmule N, et al. Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway. Science. 1997;275:1481-5 pubmed
    ..with HIV-1 in vitro resulted in increased interleukin-2 (IL-2) secretion in response to T cell activation via the CD3 and CD28 receptors...
  76. Doucey M, Goffin L, Naeher D, Michielin O, Baumgärtner P, Guillaume P, et al. CD3 delta establishes a functional link between the T cell receptor and CD8. J Biol Chem. 2003;278:3257-64 pubmed
    T cells expressing T cell receptor (TCR) complexes that lack CD3 delta, either due to deletion of the CD3 delta gene, or by replacement of the connecting peptide of the TCR alpha chain, exhibit severely impaired positive selection and ..
  77. Benson M, Mobini R, Barrenas F, Hallden C, Naluai A, Sall T, et al. A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis. Allergy. 2009;64:1286-91 pubmed publisher
    ..Analysis of SNPs in TCR pathway genes revealed that a haplotype that covers a major part of the coding sequence of ITK is a risk factor for SAR. ..
  78. Su Z, Wang H, Wan Y, Bi Z. In vitro preparation and characterization of the human CD3 epsilon epsilon homodimer and CD3 epsilon gamma and CD3 epsilon delta heterodimers. Int J Mol Med. 2009;24:437-44 pubmed
    ..It has been suggested that CD3 epsilon pairs with CD3 gamma or with CD3 delta, forming CD3 epsilon gamma and CD3 epsilon delta heterodimers that associate with alpha/beta T cell receptors (..
  79. Arhel N, Lehmann M, Clauss K, Nienhaus G, Piguet V, Kirchhoff F. The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses. J Clin Invest. 2009;119:2965-75 pubmed publisher
    ..lentiviral Nef proteins differ substantially in their ability to modulate cell surface expression of the TCR-CD3 and CD28 receptors critical for the formation and function of the IS...
  80. Nedellec S, Sabourin C, Bonneville M, Scotet E. NKG2D costimulates human V gamma 9V delta 2 T cell antitumor cytotoxicity through protein kinase C theta-dependent modulation of early TCR-induced calcium and transduction signals. J Immunol. 2010;185:55-63 pubmed publisher
    ..When compared with other human T cell subsets, including NKT and Vdelta2(neg) gammadelta T cells, TCR/CD3-activated Vgamma9Vdelta2 T cells displayed an unusually delayed and sustained intracellular calcium mobilization, ..
  81. Lam S, Kavadas F, Haider S, Noseworthy M. The respiratory presentation of severe combined immunodeficiency in two Mennonite children at a tertiary centre highlighting the importance of recognizing this pediatric emergency. Can Respir J. 2014;21:17-9 pubmed
    ..lt;4 months of age with respiratory distress at a tertiary care centre due to a recently described homozygous CD3 delta mutation found only in the Mexican Mennonite population...
  82. Caballero D, Pérez Palacios T, Caro A, Amigo J, Dahl A, Ersbøll B, et al. Prediction of pork quality parameters by applying fractals and data mining on MRI. Food Res Int. 2017;99:739-747 pubmed publisher
    ..In addition, the effect of the sequence acquisition of MRI (Gradient echo, GE; Spin echo, SE and Turbo 3D, T3D) and the predictive technique of data mining (Isotonic regression, IR and Multiple linear regression, MLR) were ..
  83. Oravecz T, Norcross M. Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120. AIDS Res Hum Retroviruses. 1993;9:945-55 pubmed
    ..We assayed the costimulatory properties of a panel of CD4 MAbs, intact HIV, and viral envelope glycoproteins in CD3-induced activation of resting T cell subpopulations...
  84. Dürrbaum Landmann I, Kaltenhäuser E, Flad H, Ernst M. HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro. J Leukoc Biol. 1994;55:545-51 pubmed
    ..Rec.gp120 significantly reduced the accessory function of monocytes to stimulate autologous lymphocytes with anti-CD3, the Fc receptor-mediated chemiluminescence of monocytes, and the expression of CD4 and Fc receptor I/II, while the ..
  85. Rajagopalan S, Xu Y, Brenner M. Retention of unassembled components of integral membrane proteins by calnexin. Science. 1994;263:387-90 pubmed
    ..protein that resides in the endoplasmic reticulum (ER), in the retention of representative chains of the TCR-CD3 complex in the ER was tested...
  86. Luzzati A, Boirivant M, Giacomini E, Giordani L, Di Modugno F, Chersi A. Interferon-gamma (IFN-gamma) can counteract the in vitro inhibitory effect of an HIV p24 immunosuppressive heptapeptide. Clin Exp Immunol. 1996;105:403-8 pubmed
    ..Thus, although the Ch7 immunosuppressive effect may not be directly related to a decreased production of IFN-gamma, an increased level of this cytokine is certainly able to counteract the negative effect of the peptide. ..
  87. Palacios E, Weiss A. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene. 2004;23:7990-8000 pubmed
    ..Recruited SFKs phosphorylate TCR ITAMs (immunoreceptor tyrosine-based activation motifs) in the CD3 and zeta chains, which then serve as docking sites for Syk-family kinases...
  88. Pearce M, Wang Y, Kelley G, Wojcikiewicz R. SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells. J Biol Chem. 2007;282:20104-15 pubmed
    ..Overall, these studies identify SPFH2 as a key ERAD pathway component and suggest that it may act as a substrate recognition factor. ..
  89. Li Y, Chen S, Yang L, Chen S, Lin C, Wang L, et al. Change in expression pattern of TCR-CD3 complex in patients with multiple myeloma. Hematology. 2011;16:143-50 pubmed publisher
    ..This immune dysfunction may be due, in part, to altered expression of the T cell receptor (TCR)-CD3 complex...
  90. Capietto A, Martinet L, Fournie J. Stimulated ?? T cells increase the in vivo efficacy of trastuzumab in HER-2+ breast cancer. J Immunol. 2011;187:1031-8 pubmed publisher
    ..Altogether, these findings indicate that combination of trastuzumab and stimulated ?? cells represents a new strategy to improve the efficacy of Herceptin (trastuzumab) in HER-2(+) breast cancer. ..
  91. Baxter A, Russell R, Duncan C, Moore M, Willberg C, Pablos J, et al. Macrophage infection via selective capture of HIV-1-infected CD4+ T cells. Cell Host Microbe. 2014;16:711-21 pubmed publisher
    ..These results have implications for establishment of the macrophage reservoir and HIV-1 dissemination in vivo. ..
  92. He Y, Rangarajan S, Kerzic M, Luo M, Chen Y, Wang Q, et al. Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR. J Biol Chem. 2015;290:19796-805 pubmed publisher
    The T cell receptor (TCR)-CD3 complex is composed of a genetically diverse αβ TCR heterodimer associated noncovalently with the invariant CD3 dimers CD3ϵγ, CD3ϵδ, and CD3ζζ...