CD2AP

Summary

Gene Symbol: CD2AP
Description: CD2 associated protein
Alias: CMS, CD2-associated protein, Cas ligand with multiple Src homology 3 (SH3) domains, adapter protein CMS, cas ligand with multiple SH3 domains
Species: human
Products:     CD2AP

Top Publications

  1. Kim J, Wu H, Green G, Winkler C, Kopp J, Miner J, et al. CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. Science. 2003;300:1298-300 pubmed
    Loss of CD2-associated protein (CD2AP), a component of the filtration complex in the kidney, causes death in mice at 6 weeks of age...
  2. Lehtonen S, Lehtonen E, Kudlicka K, Holthofer H, Farquhar M. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Am J Pathol. 2004;165:923-36 pubmed
    ..nephrin forms a multiprotein complex with cadherins and p120 catenin and with three scaffolding proteins, ZO-1, CD2AP, and CASK, in kidney glomeruli and when expressed in Madin-Darby canine kidney cells...
  3. Wells C, Fawcett J, Traweger A, Yamanaka Y, Goudreault M, Elder K, et al. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell. 2006;125:535-48 pubmed
    ..We propose that Rich1 and Amot maintain TJ integrity by the coordinate regulation of Cdc42 and by linking specific components of the TJ to intracellular protein trafficking. ..
  4. Kirsch K, Georgescu M, Shishido T, Langdon W, Birge R, Hanafusa H. The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. J Biol Chem. 2001;276:4957-63 pubmed
    CMS/CD2AP is a cytoplasmic protein critical for the integrity of the kidney glomerular filtration and the T cell function...
  5. Tibaldi E, Reinherz E. CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities. Int Immunol. 2003;15:313-29 pubmed
    ..CD2BP3 has 35% amino acid identity to CMS, a structurally related protein binding to the same highly conserved segment of the CD2 tail and known to be ..
  6. Lynch D, Winata S, Lyons R, Hughes W, Lehrbach G, Wasinger V, et al. A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem. 2003;278:21805-13 pubmed
    ..This identified several proteins, including CD2-associated protein (CD2AP), as targets for the cortactin Src homology 3 domain...
  7. Lu C, Ren W, Su X, Chen J, Wu S, Guo X, et al. CREB and Sp1 regulate the human CD2AP gene promoter activity in renal tubular epithelial cells. Arch Biochem Biophys. 2008;474:143-9 pubmed publisher
    The human CD2-associated protein (CD2AP) is involved in several molecular signaling pathways and is an important factor responsible for nephrotic syndrome...
  8. Su X, Ren W, Lu C, Chen J, Wu S, Chen R, et al. Functional characterization of the regulatory region of human CD2-associated protein promoter in HEK 293 cells. Am J Nephrol. 2009;29:203-12 pubmed publisher
    The mRNA of CD2-associated protein (CD2AP) was found to be changed in glomerular diseases...
  9. Lehtonen S, Ora A, Olkkonen V, Geng L, Zerial M, Somlo S, et al. In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. J Biol Chem. 2000;275:32888-93 pubmed
    ..mesenchyme-to-epithelium transition protein with SH3 domains), has since been cloned as a CD2-associated protein (CD2AP)...

More Information

Publications117 found, 100 shown here

  1. Bruck S, Huber T, Ingham R, Kim K, Niederstrasser H, Allen P, et al. Identification of a novel inhibitory actin-capping protein binding motif in CD2-associated protein. J Biol Chem. 2006;281:19196-203 pubmed
    CD2-associated protein (CD2AP) is a scaffold molecule that plays a critical role in the maintenance of the kidney filtration barrier. Little, however, is understood about its mechanism of function...
  2. Yaddanapudi S, Altintas M, Kistler A, Fernandez I, Möller C, Wei C, et al. CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest. 2011;121:3965-80 pubmed publisher
    ..injury results in proteinuric kidney disease, and genetic deletion of SD-associated CD2-associated protein (CD2AP) leads to progressive renal failure in mice and humans...
  3. Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, et al. CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. Traffic. 2003;4:97-112 pubmed
    ..We cloned an ubiquitous 80-kDa protein, identical to CD2-associated protein/Cas ligand with multiple SH3 domains (CD2AP/CMS), that interacts with Rab4-Q67L in the yeast two-hybrid system and in vitro...
  4. Moncalian G, Cárdenes N, Deribe Y, Spínola Amilibia M, Dikic I, Bravo J. Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain. J Biol Chem. 2006;281:38845-53 pubmed
    The CIN85/CMS (human homologs of mouse SH3KBP1/CD2AP) family of endocytic adaptor proteins has the ability to engage multiple effectors and couple cargo trafficking with the cytoskeleton...
  5. Löwik M, Groenen P, Pronk I, Lilien M, Goldschmeding R, Dijkman H, et al. Focal segmental glomerulosclerosis in a patient homozygous for a CD2AP mutation. Kidney Int. 2007;72:1198-203 pubmed
    ..Mutations in several genes were found in patients with primary FSGS, one of which is a CD2-associated protein CD2AP (originally referred to as CMS)...
  6. Gaidos G, Soni S, Oswald D, Toselli P, Kirsch K. Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation. J Cell Sci. 2007;120:2366-77 pubmed
    Members of the CMS/CIN85 protein family participate in clathrin-mediated endocytosis and play a crucial role in maintaining the kidney filtration barrier...
  7. Dustin M, Olszowy M, Holdorf A, Li J, Bromley S, Desai N, et al. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell. 1998;94:667-77 pubmed
    ..This novel protein, called CD2AP, is likely to facilitate receptor patterning in the contact area by linking specific adhesion receptors to the ..
  8. van Duijn T, Anthony E, Hensbergen P, Deelder A, Hordijk P. Rac1 recruits the adapter protein CMS/CD2AP to cell-cell contacts. J Biol Chem. 2010;285:20137-46 pubmed publisher
    ..Most recently, we found that the Rac1 C terminus associates to the ubiquitously expressed adapter protein CMS/CD2AP...
  9. Coward R, Foster R, Patton D, Ni L, Lennon R, Bates D, et al. Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes. J Am Soc Nephrol. 2005;16:629-37 pubmed
    ..the glomerulus and are dependent on the slit diaphragm (SD) proteins nephrin, podocin, and CD2-associated protein (CD2AP) to function optimally...
  10. Roldan J, Blackledge M, van Nuland N, Azuaga A. Solution structure, dynamics and thermodynamics of the three SH3 domains of CD2AP. J Biomol NMR. 2011;50:103-17 pubmed publisher
    b>CD2 associated protein (CD2AP) is an adaptor protein that plays an important role in cell to cell union needed for the kidney function...
  11. Ceregido M, Garcia Pino A, Ortega Roldan J, Casares S, Lopez Mayorga O, Bravo J, et al. Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*. FEBS J. 2013;280:3399-415 pubmed publisher
    The CD2AP (CD2-associated protein) and CIN85 (Cbl-interacting protein of 85 kDa) adaptor proteins each employ three Src homology 3 (SH3) domains to cluster protein partners and ensure efficient signal transduction and down-regulation of ..
  12. Balineni P, Arcot R, Devygounder K, Rahaman K, Narayansamy B, Prabhu M, et al. Malignant peripheral nerve sheath tumor of the pancreas-A case report. Int J Surg Case Rep. 2019;55:239-242 pubmed publisher
    ..Patient is a known case of diabetes mellitus II. On abdominal examination a large mass of 10*8 cms was palpated in the left hypochondrium, left lumbar, and umbilical region...
  13. Ndisang J, Chibbar R. Heme Oxygenase Improves Renal Function by Potentiating Podocyte-Associated Proteins in Nω-Nitro-l-Arginine-Methyl Ester (l-NAME)-Induced Hypertension. Am J Hypertens. 2015;28:930-42 pubmed publisher
    ..HO) is cytoprotective, its effects on podocyte regulators like podocalyxin, podocin, CD2-associated protein (CD2AP) in renal dysfunction in N (ω)-nitro-l-arginine-methyl ester (l-NAME) hypertension are largely unclear...
  14. Ma C, Kang L, Ren H, Zhang D, Kong L. Simiao pill ameliorates renal glomerular injury via increasing Sirt1 expression and suppressing NF-κB/NLRP3 inflammasome activation in high fructose-fed rats. J Ethnopharmacol. 2015;172:108-17 pubmed publisher
    ..Glomerular protein levels of nephrin, podocin, CD2-associated protein (CD2AP), interleukin (IL)-1β, sirtuin 1 (Sirt1), nuclear factor kappaB (NF-κB) and pyrin domain containing 3 (NLRP3)..
  15. Shen J, Wei Y, Li Y, Qiao J, Li Y. Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress. Metab Brain Dis. 2017;32:1163-1172 pubmed publisher
    ..a rat model of depression complicated by insulin resistance using a 12-week exposure to chronic mild stress (CMS) and investigated the therapeutic effects of curcumin...
  16. Ge L, Zhu M, Yang J, Wang F, Zhang R, Zhang J, et al. Differential proteomic analysis of the anti-depressive effects of oleamide in a rat chronic mild stress model of depression. Pharmacol Biochem Behav. 2015;131:77-86 pubmed publisher
    ..In the present study, the chronic mild stress (CMS) model was used to investigate the antidepressant-like activity of oleamide...
  17. Ito M, Ohno K. Protein-anchoring therapy to target extracellular matrix proteins to their physiological destinations. Matrix Biol. 2018;68-69:628-636 pubmed publisher
    Endplate acetylcholinesterase (AChE) deficiency is a form of congenital myasthenic syndrome (CMS) caused by mutations in COLQ, which encodes collagen Q (ColQ)...
  18. Veroniki A, Cogo E, Rios P, Straus S, Finkelstein Y, Kealey R, et al. Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes. BMC Med. 2017;15:95 pubmed publisher
    ..We aimed to compare the risk of congenital malformations (CMs) and prenatal outcomes of AEDs in infants/children who were exposed to AEDs in utero through a systematic review ..
  19. Dodd A, Bulka C, Jahangir A, Mir H, Obremskey W, Sethi M. Predictors of 30-day mortality following hip/pelvis fractures. Orthop Traumatol Surg Res. 2016;102:707-10 pubmed publisher
    ..2013 and expected to increase with a growing geriatric population, the Center for Medicare and Medicaid Services (CMS) and Hospital Quality Alliance (HQA) began publicly reporting 30-day mortality rates so that hospitals and ..
  20. Morey T, Winick Ng W, Seah C, Rylett R. Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP. Front Mol Neurosci. 2017;10:415 pubmed publisher
    ..neurons, and mutations of this enzyme are linked to the neuromuscular disorder congenital myasthenic syndrome (CMS)...
  21. Frankenreiter S, Bednarczyk P, Kniess A, Bork N, Straubinger J, Koprowski P, et al. cGMP-Elevating Compounds and Ischemic Conditioning Provide Cardioprotection Against Ischemia and Reperfusion Injury via Cardiomyocyte-Specific BK Channels. Circulation. 2017;136:2337-2355 pubmed publisher
    ..This study establishes mitochondrial CMBK channels as a promising target for limiting acute cardiac damage and adverse long-term events that occur after myocardial infarction. ..
  22. Wang S, Tian M, Yang R, Jing Y, Chen W, Wang J, et al. 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE-/- Mice Exposed to Chronic Mild Stress. Cardiovasc Toxicol. 2018;18:420-430 pubmed publisher
    Chronic mild stress (CMS) has been demonstrated to contribute to atherosclerosis...
  23. Ding X, Li J, Zhang H, He T, Han S, Li Y, et al. Identification of miRNAs and their targets by high-throughput sequencing and degradome analysis in cytoplasmic male-sterile line NJCMS1A and its maintainer NJCMS1B of soybean. BMC Genomics. 2016;17:24 pubmed publisher
    Cytoplasmic male sterility (CMS) provides crucial breeding materials that facilitate hybrid seed production in various crops, and thus plays an important role in the study of hybrid vigor (heterosis), in plants...
  24. Qiong W, Yong Liang Z, Ying Hui L, Shan Guang C, Jiang Hui G, Yi Xi C, et al. The memory enhancement effect of Kai Xin San on cognitive deficit induced by simulated weightlessness in rats. J Ethnopharmacol. 2016;187:9-16 pubmed publisher
    ..Previous study showed KXS could improve CMS-induced memory impairment in rats...
  25. Ramasamy I. Recent advances in physiological lipoprotein metabolism. Clin Chem Lab Med. 2014;52:1695-727 pubmed publisher
    ..protein 1 and an angiopoietin-like protein play a role in lipoprotein lipase (LPL)-mediated hydrolysis of secreted CMs and VLDL so that the right amount of fatty acid is delivered to the right tissue at the right time...
  26. Raij L, Tian R, Wong J, He J, Campbell K. Podocyte injury: the role of proteinuria, urinary plasminogen, and oxidative stress. Am J Physiol Renal Physiol. 2016;311:F1308-F1317 pubmed publisher
    ..models of proteinuric kidney disease associated with podocyte injury: Tg26 HIV-associated nephropathy and the Cd2ap-/- model of FSGS...
  27. Huang H, Zhang S, Shen W, Wong H, Xie D. Gene set enrichment ensemble using fold change data only. J Biomed Inform. 2015;57:189-203 pubmed publisher
    ..Human embryonic stem cell derived cardiomyocytes (hESC-CM) is a good representative of this category. hESC-CMs, with its role as a potentially unlimited source of human heart cells for regenerative medicine, have attracted the ..
  28. Kawamura T, Miyagawa S, Fukushima S, Kashiyama N, Kawamura A, Ito E, et al. Structural Changes in N-Glycans on Induced Pluripotent Stem Cells Differentiating Toward Cardiomyocytes. Stem Cells Transl Med. 2015;4:1258-64 pubmed publisher
    ..In this study, N-glycans were isolated from human iPSCs, iPSC-derived cardiomyocytes (iPSC-CMs), and human cardiomyocytes (hCMCs)...
  29. Wilkinson R, Hill D, Hickerson W. Outcome analysis of colistin-treated burn center patients. Burns. 2017;43:1244-1249 pubmed publisher
    Intravenous colistimethate sodium (CMS) use in burn center patients is increasing due to the emergence of multidrug-resistant gram-negative bacteria...
  30. Usami Y, Popov S, Gottlinger H. Potent rescue of human immunodeficiency virus type 1 late domain mutants by ALIX/AIP1 depends on its CHMP4 binding site. J Virol. 2007;81:6614-22 pubmed
    ..PRD), but not on the binding sites for Tsg101, endophilin, CIN85, or for the newly identified binding partner, CMS, within the PRD...
  31. Whitcomb W, Lagu T, Krushell R, Lehman A, Greenbaum J, McGirr J, et al. Experience with Designing and Implementing a Bundled Payment Program for Total Hip Replacement. Jt Comm J Qual Patient Saf. 2015;41:406-13 pubmed
    ..In July 2015 the Centers for Medicare & Medicaid Services (CMS) proposed the Comprehensive Care for Joint Replacement Model to test bundled payment for hip and knee replacement...
  32. Zhao N, Xu X, Wamboldt Y, Mackenzie S, Yang X, Hu Z, et al. MutS HOMOLOG1 silencing mediates ORF220 substoichiometric shifting and causes male sterility in Brassica juncea. J Exp Bot. 2016;67:435-44 pubmed publisher
    Cytoplasmic male sterility (CMS) has consistently been associated with the expression of mitochondrial open reading frames (ORFs) that arise from genomic rearrangements...
  33. Cao Y, Hjort M, Chen H, Birey F, Leal Ortiz S, Han C, et al. Nondestructive nanostraw intracellular sampling for longitudinal cell monitoring. Proc Natl Acad Sci U S A. 2017;114:E1866-E1874 pubmed publisher
    ..sequences analyzed from a population of cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs), 41 were accurately quantified...
  34. Wang J, Aierken G, Li X, Li L, Mao X. Testing the absorption of the extracts of Coreopsis tinctoria Nutt. in the intestinal canal in rats using an Ussing chamber. J Ethnopharmacol. 2016;186:73-83 pubmed publisher
    ..0×10(-6) to 10×10(-6)cms(-1). Papp of marein in the duodenum and jejunum was <1.0×10(-6), and was 1...
  35. Zhang H, Che J, Ge Y, Pei Y, Zhang L, Liu Q, et al. Ability of Rf5 and Rf6 to Restore Fertility of Chinsurah Boro II-type Cytoplasmic Male Sterile Oryza Sativa (ssp. Japonica) Lines. Rice (N Y). 2017;10:2 pubmed publisher
    ..japonica) hybrids have been developed mainly using Chinsurah Boro II (BT)-type cytoplasmic male sterility (CMS)...
  36. Zivin K, Miller B, Finke B, Bitton A, Payne P, Stowe E, et al. Behavioral Health and the Comprehensive Primary Care (CPC) Initiative: findings from the 2014 CPC behavioral health survey. BMC Health Serv Res. 2017;17:612 pubmed publisher
    ..Care (CPC) initiative, a four-year multi-payer initiative of the Centers for Medicare and Medicaid Services (CMS)...
  37. Spitalieri P, Talarico R, Caioli S, Murdocca M, Serafino A, Girasole M, et al. Modelling the pathogenesis of Myotonic Dystrophy type 1 cardiac phenotype through human iPSC-derived cardiomyocytes. J Mol Cell Cardiol. 2018;118:95-109 pubmed publisher
    ..We assessed the appropriateness of patient-specific induced pluripotent stem cell-derived cardiomyocytes (CMs) as a model to recapitulate some aspects of the pathogenetic mechanism involving cardiac manifestations in DM1 ..
  38. Gross M, Pinhasov A. Chronic mild stress in submissive mice: Marked polydipsia and social avoidance without hedonic deficit in the sucrose preference test. Behav Brain Res. 2016;298:25-34 pubmed publisher
    In the Chronic Mild Stress (CMS) protocol, rodents are exposed to unpredictable stressors to induce anxiety-like behavior and hedonic deficit in the Sucrose Preference test (SPT)...
  39. Papp M, Gruca P, Lasoń Tyburkiewicz M, Willner P. Antidepressant, anxiolytic and procognitive effects of rivastigmine and donepezil in the chronic mild stress model in rats. Psychopharmacology (Berl). 2016;233:1235-43 pubmed publisher
    ..pro-cognitive effects in a well-validated animal model of depression and cognitive impairment, chronic mild stress (CMS). Rats were subjected to CMS for a total of 8 weeks...
  40. Rosenkrantz A, Nicola G, Allen B, Hughes D, Hirsch J. MACRA, MIPS, and the New Medicare Quality Payment Program: An Update for Radiologists. J Am Coll Radiol. 2017;14:316-323 pubmed publisher
    ..In April 2016, CMS published an initial proposed rule for MACRA, renaming it the Quality Payment Program (QPP)...
  41. Talkhabi M, Razavi S, Salari A. Global transcriptomic analysis of induced cardiomyocytes predicts novel regulators for direct cardiac reprogramming. J Cell Commun Signal. 2017;11:193-204 pubmed publisher
    ..De novo generated cardiomyocytes (CMs) are a great cellular source for cell-based therapy and other potential applications...
  42. Goodrow R, Desai S, Treat J, Panama B, Desai M, Nesterenko V, et al. Biophysical comparison of sodium currents in native cardiac myocytes and human induced pluripotent stem cell-derived cardiomyocytes. J Pharmacol Toxicol Methods. 2018;90:19-30 pubmed publisher
    Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are used for safety pharmacology and to investigate genetic diseases affecting cardiac ion channels...
  43. Panni S, Salvioli S, Santonico E, Langone F, Storino F, Altilia S, et al. The adapter protein CD2AP binds to p53 protein in the cytoplasm and can discriminate its polymorphic variants P72R. J Biochem. 2015;157:101-11 pubmed publisher
    ..e. SH3 and WW), and we present the first demonstration that the purified SH3 domains of the CD2AP/Cin85 protein family are able to directly bind the p53 protein, and to discriminate between the two polymorphic ..
  44. Li C, Chen S, Chen X, Mu R, Wang S, Geng D, et al. ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress. Brain Res Bull. 2016;124:40-7 pubmed publisher
    ..herein aimed to explore the antidepressant-like mechanism of hesperidin in mice induced by chronic mild stress (CMS)...
  45. Jo Y, Ha Y, Lee J, Park M, Bergsma A, Choi H, et al. Fine mapping of Restorer-of-fertility in pepper (Capsicum annuum L.) identified a candidate gene encoding a pentatricopeptide repeat (PPR)-containing protein. Theor Appl Genet. 2016;129:2003-17 pubmed publisher
    ..Although the mitochondrial candidate genes that might be responsible for cytoplasmic male sterility (CMS) have been identified, the nuclear Restorer-of-fertility (Rf) gene has not been isolated...
  46. Koci B, Luerman G, Duenbostell A, Kettenhofen R, Bohlen H, Coyle L, et al. An impedance-based approach using human iPSC-derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities. Toxicol Appl Pharmacol. 2017;329:121-127 pubmed publisher
    ..Human induced pluripotent stem cell cardiomyocytes (hIPSC-CMs) have demonstrated utility in cardiac safety and toxicity screening...
  47. Caggiano S, Khirani S, Verrillo E, Barnerias C, Amaddeo A, Gitiaux C, et al. Sleep in infants with congenital myasthenic syndromes. Eur J Paediatr Neurol. 2017;21:842-851 pubmed publisher
    Infants with congenital myasthenic syndrome (CMS) are at risk of brief resolved unexplained event (BRUE) and sleep-disordered breathing...
  48. Hallas T, Eisen B, Shemer Y, Ben Jehuda R, Mekies L, Naor S, et al. Investigating the cardiac pathology of SCO2-mediated hypertrophic cardiomyopathy using patients induced pluripotent stem cell-derived cardiomyocytes. J Cell Mol Med. 2017;: pubmed publisher
    ..of the disease, we were the first to generate induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPSC-CMs) from SCO2-mutated patients...
  49. Sato S, Zhao Y, Imai M, Simister P, Feller S, Trackman P, et al. Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide. PLoS ONE. 2013;8:e77288 pubmed publisher
    ..Thus, LOX-PP interacts with CIN85 via a novel SH3-binding motif and this association reduces CIN85-promoted invasion by breast cancer cells. ..
  50. Hootz T, Mykota D, Fauchoux L. Strength-based crisis programming: Evaluating the process of care. Eval Program Plann. 2016;54:50-62 pubmed publisher
    ..evaluation framework was used to explore client and service providers' experiences of Crisis Management Services (CMS), their perceptions of the services provided, and the process of client engagement CMS offers...
  51. Bergman J, Laviana A, Kwan L, Lerman S, Aronson W, Bennett C, et al. Variations in payment patterns for surgical care in the centers for Medicare and Medicaid Services. Surgery. 2017;161:312-319 pubmed publisher
    ..provider and regional variation in payments made to surgeons by the Centers for Medicare & Medicaid Services (CMS) by indexing payments to unique beneficiaries treated and examined the proportion of charges that resulted in ..
  52. Kramer H, Gibson B, Livnat Y, Thraen I, Brody A, Rupper R. Evaluation of an Electronic Module for Reconciling Medications in Home Health Plans of Care. Appl Clin Inform. 2016;7:412-24 pubmed publisher
    ..paper-based) simulated current practice - reconciling medication discrepancies between a paper plan of care (CMS 485) and a simulated Electronic Health Record (EHR)...
  53. Sandhu S, Hua W, MaCurdy T, Franks R, Avagyan A, Kelman J, et al. Near real-time surveillance for Guillain-Barré syndrome after influenza vaccination among the Medicare population, 2010/11 to 2013/14. Vaccine. 2017;35:2986-2992 pubmed publisher
    ..The Food and Drug Administration (FDA) began collaborating with the Centers for Medicare and Medicaid Services (CMS) to develop near real-time vaccine safety surveillance capabilities in 2006 and has been monitoring for the risk of ..
  54. Li Q, Li B, Liu C, Wang L, Tang J, Hong L. Protective role of Nrf2 against mechanical-stretch-induced apoptosis in mouse fibroblasts: a potential therapeutic target of mechanical-trauma-induced stress urinary incontinence. Int Urogynecol J. 2018;29:1469-1477 pubmed publisher
    ..Nrf2 overexpressing cells were respectively divided into two groups-nonintervention and cyclic mechanical strain (CMS)-subjected to CMS of 5333 μ (1...
  55. Yamanaka S, Zahanich I, Wersto R, Boheler K. Enhanced proliferation of monolayer cultures of embryonic stem (ES) cell-derived cardiomyocytes following acute loss of retinoblastoma. PLoS ONE. 2008;3:e3896 pubmed publisher
    ..We conclude that this in vitro model will facilitate the analysis of cell cycle control mechanisms of CMs.
  56. Xia A, Jacob A, Tabassum M, Herrmann C, Murphy J. Production of hydrogen, ethanol and volatile fatty acids through co-fermentation of macro- and micro-algae. Bioresour Technol. 2016;205:118-25 pubmed publisher
    ..5% dilute H2SO4 at 135°C for 15min, effected a total yield of carbohydrate monomers (CMs) of 0.268g/g volatile solids (VS). The CMs were dominating by glucose and mannitol and most (ca...
  57. Levine D, Healey M, Wright A, Bates D, Linder J, Samal L. Changes in the quality of care during progress from stage 1 to stage 2 of Meaningful Use. J Am Med Inform Assoc. 2017;24:394-397 pubmed publisher
    The Centers for Medicare and Medicaid Services (CMS) canceled Meaningful Use (MU), replacing it with Advancing Care Information, which preserves many MU elements...
  58. Tsuji K, Paunescu T, Suleiman H, Xie D, Mamuya F, Miner J, et al. Re-characterization of the Glomerulopathy in CD2AP Deficient Mice by High-Resolution Helium Ion Scanning Microscopy. Sci Rep. 2017;7:8321 pubmed publisher
    ..ultrastructural characteristics of proteinuric glomerulopathy in mice with CD2-associated protein (CD2AP) deficiency...
  59. Cowger J, Stulak J, Shah P, Dardas T, Pagani F, Dunlay S, et al. Impact of Center Left Ventricular Assist Device Volume on Outcomes After Implantation: An INTERMACS Analysis. JACC Heart Fail. 2017;5:691-699 pubmed publisher
    ..In order for a center to qualify for reimbursement, Centers for Medicare and Medicaid Services (CMS) requires it to implant ≥10 LVADs or total artificial hearts over a 3-year period...
  60. Song J, Zhang Q, Wang S, Yang F, Chen Z, Dong Q, et al. Cleavage of caspase-12 at Asp94, mediated by endoplasmic reticulum stress (ERS), contributes to stretch-induced apoptosis of myoblasts. J Cell Physiol. 2018;: pubmed publisher
    ..that apoptosis was elevated in a time-dependent manner when myoblasts were subjected to cyclic mechanical stretch (CMS) for 12, 24, and 36?hr...
  61. Lu H, Whittaker R, Price J, Vega R, Pfeiffer E, Cerignoli F, et al. High Throughput Measurement of Ca++ Dynamics in Human Stem Cell-Derived Cardiomyocytes by Kinetic Image Cytometery: A Cardiac Risk Assessment Characterization Using a Large Panel of Cardioactive and Inactive Compounds. Toxicol Sci. 2015;148:503-16 pubmed publisher
    Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are emerging as a powerful in vitro model for cardiac safety assessment which may allow for better identification of compounds with poor arrhythmogenic liability ..
  62. Rimler S, Gale B, Reede D. Diagnosis-related Groups and Hospital Inpatient Federal Reimbursement. Radiographics. 2015;35:1825-34 pubmed publisher
    ..The Centers for Medicare & Medicaid Services (CMS) assigns each DRG a weight that the CMS uses in conjunction with hospital-specific data to determine reimbursement...
  63. Galasso O, Riccelli D, De Gori M, De Benedetto M, Orlando N, Gasparini G, et al. Quality of Life and Functional Results of Arthroscopic Partial Repair of Irreparable Rotator Cuff Tears. Arthroscopy. 2017;33:261-268 pubmed publisher
    ..The Constant and Murley score (CMS) was used to assess patients' functionality pre- and postoperatively...
  64. Correia C, Koshkin A, Duarte P, Hu D, Teixeira A, Domian I, et al. Distinct carbon sources affect structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells. Sci Rep. 2017;7:8590 pubmed publisher
    The immature phenotype of human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) constrains their potential in cell therapy and drug testing...
  65. Zeng H, Balasubramanian B, Lagrutta A, Sannajust F. Response of human induced pluripotent stem cell-derived cardiomyocytes to several pharmacological agents when intrinsic syncytial pacing is overcome by acute external stimulation. J Pharmacol Toxicol Methods. 2018;91:18-26 pubmed publisher
    ..was gradually shortened mainly in the relaxation phase of each beat cycle; 2) typical responses of iCells hiPSC-CMs to all tested pharmacological agents were either attenuated or even eliminated by pacing, in a concentration- and ..
  66. Ovchinnikova E, Hoes M, Ustyantsev K, Bomer N, de Jong T, van der Mei H, et al. Modeling Human Cardiac Hypertrophy in Stem Cell-Derived Cardiomyocytes. Stem Cell Reports. 2018;10:794-807 pubmed publisher
    ..The objective of our study is to determine whether human embryonic stem cell-derived cardiomyocytes (hESC-CMs) subjected to mechanical stretch can be used as an adequate in vitro model for studying molecular mechanisms of ..
  67. Jiang W, Wang H, Li Y, Zhou T, Hu X. Meta-analysis of differences in Constant-Murley scores for three mid-shaft clavicular fracture treatments. Oncotarget. 2017;8:83251-83260 pubmed publisher
    ..of non-operative treatment, plate fixation, and intramedullary pin fixation in terms of the Constant-Murley Score (CMS) for treatment of mid-shaft clavicular fracture...
  68. Ben Ari M, Naor S, Zeevi Levin N, Schick R, Ben Jehuda R, Reiter I, et al. Developmental changes in electrophysiological characteristics of human-induced pluripotent stem cell-derived cardiomyocytes. Heart Rhythm. 2016;13:2379-2387 pubmed publisher
    ..proposed that throughout differentiation of human induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs), only 3 types of action potentials (APs) exist: nodal-, atrial-, and ventricular-like...
  69. Zhang Y, Yu Z, Jiang D, Liang X, Liao S, Zhang Z, et al. iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-? Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy. Stem Cell Reports. 2016;7:749-763 pubmed publisher
    ..to tumor necrosis factor alpha (TNF-?)-induced tunneling nanotube (TNT) formation for mitochondrial transfer to CMs, which is regulated via the TNF-?/NF-?B/TNF?IP2 signaling pathway...
  70. Jump R, Gaur S, Katz M, Crnich C, Dumyati G, Ashraf M, et al. Template for an Antibiotic Stewardship Policy for Post-Acute and Long-Term Care Settings. J Am Med Dir Assoc. 2017;18:913-920 pubmed publisher
    ..for multidrug resistance and Clostridium difficile infections, the Centers for Medicare and Medicaid services (CMS) will require all long-term care (LTC) facilities to establish an antibiotic stewardship program by November 2017...
  71. Prabhu A, Kim C, De Guzman E, Zhao E, Madill E, Cohen J, et al. Reputation Management and Content Control: An Analysis of Radiation Oncologists' Digital Identities. Int J Radiat Oncol Biol Phys. 2017;99:1083-1091 pubmed publisher
    ..The Centers for Medicare and Medicaid Services (CMS) Physician Comparable Downloadable File was used to identify all Medicare-participating radiation oncologists in ..
  72. George D, Smith M, Draugalis J, Tolma E, Keast S, Wilson J. Community pharmacists' beliefs regarding improvement of Star Ratings scores using the Theory of Planned Behavior. J Am Pharm Assoc (2003). 2017;: pubmed publisher
    The Centers for Medicare and Medicaid Services (CMS) is moving toward a value-based model, which includes the Five-Star Quality Rating System (Star Ratings)...
  73. Kim Y, Zhang D. Molecular Control of Male Fertility for Crop Hybrid Breeding. Trends Plant Sci. 2018;23:53-65 pubmed publisher
    In many plant species, male-sterile female lines with cytoplasmic male sterility (CMS) or nuclear-controlled environment-sensitive genic male sterility (EGMS) have long been used to efficiently produce hybrids that harness hybrid vigor ..
  74. Cho G, Lee D, Tampakakis E, Murphy S, Andersen P, Uosaki H, et al. Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy. Cell Rep. 2017;18:571-582 pubmed publisher
    ..We previously showed that there is a neonatal arrest of long-term cultured PSC-derived cardiomyocytes (PSC-CMs). Here, we demonstrate that PSC-CMs mature into adult CMs when transplanted into neonatal hearts...
  75. Khodambashi S, Nytrø Ã. Reviewing clinical guideline development tools: features and characteristics. BMC Med Inform Decis Mak. 2017;17:132 pubmed publisher
    ..We also explored tools and Content Management Systems (CMS) used in representative organisations and international communities that develop and maintain GLs...
  76. Ireys H, Brach C, Anglin G, Devers K, Burton R. After The Demonstration: What States Sustained After the End of Federal Grants to Improve Children's Health Care Quality. Matern Child Health J. 2018;22:195-203 pubmed publisher
    Introduction Under the CHIPRA Quality Demonstration Grant Program, CMS awarded $100 million through 10 grants that 18 state Medicaid agencies implemented between 2010 and 2015...
  77. Kwon S, Oh S, Nacke M, Mostov K, Lipschutz J. Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex. J Biol Chem. 2016;291:25462-25475 pubmed
    ..The adaptor protein CD2AP-mediated internalization following cell surface delivery appears to contribute to the Golgi accumulation of GPRC5B,..
  78. Smolyakov G, Cauquil M, Séverac C, Lachaize V, Guilbeau Frugier C, Sénard J, et al. Biophysical properties of cardiomyocyte surface explored by multiparametric AFM. J Struct Biol. 2017;198:28-37 pubmed publisher
    ..AFM mode was adapted to qualitative and quantitative study of the lateral membrane of cardiomyocytes (CMs), extending this powerful mode to the study of soft cells...
  79. Ouyang N, Zhang P, Fu R, Shen G, Jiang L, Fang B. Mechanical strain promotes osteogenic differentiation of bone mesenchymal stem cells from ovariectomized rats via the phosphoinositide 3?kinase/Akt signaling pathway. Mol Med Rep. 2017;: pubmed publisher
    ..The aim of the current study was to investigate the effect of continuous mechanical strain (CMS) on osteogenic differentiation of bone mesenchymal stem cells (BMSCs) from ovariectomized rats (OVX BMSCs)...
  80. Pei F, Jiang J, Bai S, Cao H, Tian L, Zhao Y, et al. Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells. Stem Cell Res. 2017;19:94-103 pubmed publisher
    ..For clinical transplantation applications of hPSC-derived cardiomyocytes (hPSC-CMs), culturing cells in an albumin containing environment raises the concern of pathogen contamination and ..
  81. Wei H, Wu J, Liu Z. Studying KCNQ1 Mutation and Drug Response in Type 1 Long QT Syndrome Using Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Methods Mol Biol. 2018;1684:7-28 pubmed publisher
    Patient-specific human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (hiPSC-CMs) are becoming a valuable model for studying inherited cardiac arrhythmias...
  82. Nofi C, Bogatyryov Y, Dedkov E. Preservation of Functional Microvascular Bed Is Vital for Long-Term Survival of Cardiac Myocytes Within Large Transmural Post-Myocardial Infarction Scar. J Histochem Cytochem. 2017;:22155417741640 pubmed publisher
    ..The infarcted/scarred area has a small continually retained population of surviving CMs in subendocardial and subepicardial regions...
  83. Højgaard K, Christiansen S, Bouzinova E, Wiborg O. Disturbances of diurnal phase markers, behavior, and clock genes in a rat model of depression; modulatory effects of agomelatine treatment. Psychopharmacology (Berl). 2018;235:627-640 pubmed publisher
    ..The present study focuses on circadian rhythm disturbances in the chronic mild stress (CMS) animal model of depression and examined whether the atypical antidepressant, agomelatine, which is mediating its ..
  84. Dua A, Koprowski S, Ali F, Desai S. Factors that Predict Failure to Meet Merit-Based Incentive Payment System Quality Measures for Asymptomatic Carotid Endarterectomy. Ann Vasc Surg. 2018;48:127-132 pubmed publisher
    ..Further evaluation of the causative factors that lead to surgeon underperformance could help to improve the quality of care. ..
  85. Villafuerte F, Corante N, Anza Ramirez C, Figueroa Mujíca R, Vizcardo Galindo G, Mercado A, et al. Plasma soluble erythropoietin receptor is decreased during sleep in Andean highlanders with Chronic Mountain Sickness. J Appl Physiol (1985). 2016;121:53-8 pubmed publisher
    Excessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a highly prevalent syndrome in Andean highlanders...
  86. Samimi M, Durieux Verde M, Caille A, Mazereeuw Hautier J, Boccara O, Martin L, et al. Clinical and hemodynamic risk factors associated with discrepancies in lower limb length with capillary malformations - data from the national paediatric French cohort CONAPE. Br J Dermatol. 2017;: pubmed publisher
    Genetics discoveries have allowed for better understanding capillary malformations (CMs) with overgrowth syndrome. However, molecular analyses are still not easy to perform or interpret. Other analytical methods are needed.
  87. Sirunyan A, Tumasyan A, Adam W, Ambrogi F, Asilar E, Bergauer T, et al. Search for Supersymmetry in pp Collisions at sqrt[s]=13??TeV in the Single-Lepton Final State Using the Sum of Masses of Large-Radius Jets. Phys Rev Lett. 2017;119:151802 pubmed publisher
    ..The search uses a sample of proton-proton collision data at sqrt[s]=13??TeV recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of 35.9??fb^{-1}...
  88. Simon M, Durand S, Pluta N, Gobron N, Botran L, Ricou A, et al. Genomic Conflicts that Cause Pollen Mortality and Raise Reproductive Barriers in Arabidopsis thaliana. Genetics. 2016;203:1353-67 pubmed publisher
    ..First, the Shahdara cytoplasm induces gametophytic cytoplasmic male sterility (CMS) controlled by several nuclear loci...
  89. Baljinnyam E, Venkatesh S, Gordan R, Mareedu S, Zhang J, Xie L, et al. Effect of densely ionizing radiation on cardiomyocyte differentiation from human-induced pluripotent stem cells. Physiol Rep. 2017;5: pubmed publisher
    ..5, 3, and 10 cGy. Subsequently, the hiPSCs were differentiated into beating cardiac myocytes (hiPSC-CMs)...
  90. Desrosiers M, Weathers P. Artemisinin permeability via Caco-2 cells increases after simulated digestion of Artemisia annua leaves. J Ethnopharmacol. 2018;210:254-259 pubmed publisher
    ..03 × 10-5cms-1) compared to pure artemisinin (Papp = 5.03 × 10-5cms-1)...
  91. Park H, Seong S, Min S, Ha T. CD2-associated protein/phosphoinositide 3-kinase signaling has a preventive role in angiotensin II-induced podocyte apoptosis. Int J Biochem Cell Biol. 2016;79:370-381 pubmed publisher
    ..barrier and is linked to the actin-based cytoskeleton by adaptor proteins, including CD2-associated protein (CD2AP)...
  92. Kim H, Yoon J, Li H, Jeong G, Park J, Shin S, et al. Functional expression and pharmaceutical efficacy of cardiac-specific ion channels in human embryonic stem cell-derived cardiomyocytes. Sci Rep. 2017;7:13821 pubmed publisher
    ..The highly purified hESC-derived cardiomyocytes (hESC-CMs) expressed several cardiomyocyte-specific markers including cTnT, MLC2a, and ?-SA, but not pluripotency markers, ..