Gene Symbol: CD25
Description: interleukin 2 receptor subunit alpha
Alias: CD25, IDDM10, IL2R, IMD41, TCGFR, p55, interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2R subunit alpha, TAC antigen, interleukin 2 receptor, alpha
Species: human
Products:     CD25

Top Publications

  1. Bianchini R, Bistoni O, Alunno A, Petrillo M, Ronchetti S, Sportoletti P, et al. CD4(+) CD25(low) GITR(+) cells: a novel human CD4(+) T-cell population with regulatory activity. Eur J Immunol. 2011;41:2269-78 pubmed publisher
    ..peripheral tolerance, are characterized by markers such as forkhead winged-helix transcription factor (FOXP3) and CD25, and produce suppressive cytokines, such as IL-10 and TGF-?...
  2. Brusko T, Wasserfall C, Hulme M, Cabrera R, Schatz D, Atkinson M. Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation. PLoS ONE. 2009;4:e7980 pubmed publisher
    b>CD25, a component of the IL-2 receptor, is important in T cell proliferation, activation induced cell death, as well as the actions of both regulatory (Treg) and effector (Teff) T cells...
  3. Hafler D, Compston A, Sawcer S, Lander E, Daly M, De Jager P, et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med. 2007;357:851-62 pubmed
    ..94x10(-7)) and multiple SNPs in the HLA-DRA locus (P=8.94x10(-81)). Alleles of IL2RA and IL7RA and those in the HLA locus are identified as heritable risk factors for multiple sclerosis. ..
  4. Brand O, Lowe C, Heward J, Franklyn J, Cooper J, Todd J, et al. Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin Endocrinol (Oxf). 2007;66:508-12 pubmed
    ..identified genetic association between type 1 diabetes (T1D) and the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region on chromosome 10p15...
  5. Hinks A, Ke X, Barton A, Eyre S, Bowes J, Worthington J, et al. Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis. Arthritis Rheum. 2009;60:251-7 pubmed publisher
    IL2RA/CD25, the gene for interleukin-2 receptor alpha, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single-nucleotide ..
  6. Alcina A, Fedetz M, Ndagire D, Fernandez O, Leyva L, Guerrero M, et al. IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D). PLoS ONE. 2009;4:e4137 pubmed publisher
    IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity...
  7. Hueman M, Stojadinovic A, Storrer C, Foley R, Gurney J, Shriver C, et al. Levels of circulating regulatory CD4+CD25+ T cells are decreased in breast cancer patients after vaccination with a HER2/neu peptide (E75) and GM-CSF vaccine. Breast Cancer Res Treat. 2006;98:17-29 pubmed
    ..patients including pre- and post-vaccination samples from seven vaccinated HLA-A2+ patients were stained for CD4, CD25, and CD69 as well as CD8 and E75:HLA-A2 Ig dimer and quantified by flow cytometry...
  8. Stauber D, Debler E, Horton P, Smith K, Wilson I. Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci U S A. 2006;103:2788-93 pubmed
    ..The IL-2/gamma(c) interface itself exhibits the smallest buried surface and the fewest hydrogen bonds in the complex, which is consistent with its promiscuous use in other cytokine receptor complexes. ..
  9. Wang X, Rickert M, Garcia K. Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science. 2005;310:1159-63 pubmed
    ..This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics. ..

More Information


  1. Dendrou C, Plagnol V, Fung E, Yang J, Downes K, Cooper J, et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet. 2009;41:1011-5 pubmed publisher show that differences in surface expression of the human interleukin-2 (IL-2) receptor alpha (IL2RA, or CD25) protein are restricted to particular immune cell types and correlate with several haplotypes in the IL2RA region ..
  2. Jin Y, Birlea S, Fain P, Gowan K, Riccardi S, Holland P, et al. Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med. 2010;362:1686-97 pubmed publisher
  3. Reeves R, Leonard W, Nissen M. Binding of HMG-I(Y) imparts architectural specificity to a positioned nucleosome on the promoter of the human interleukin-2 receptor alpha gene. Mol Cell Biol. 2000;20:4666-79 pubmed
    ..Together, these findings suggest a role for the HMG-I(Y) protein in assisting the remodeling of a critically positioned nucleosome on the PRRII promoter element during IL-2Ralpha transcriptional activation in lymphocytes in vivo. ..
  4. Horiuchi S, Koyanagi Y, Tanaka Y, Waki M, Matsumoto A, Zhou Y, et al. Altered interleukin-2 receptor alpha-chain is expressed in human T-cell leukaemia virus type-I-infected T-cell lines and human peripheral blood mononuclear cells of adult T-cell leukaemia patients through an alternative splicing mechanism. Immunology. 1997;91:28-34 pubmed
    ..Our results indicate that an altered IL-2R alpha chain is expressed in HTLV-I-infected T lymphocytic cell lines and in ATL patients. ..
  5. Algarte M, Lecine P, Costello R, Plet A, Olive D, Imbert J. In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells. EMBO J. 1995;14:5060-72 pubmed
    ..b>CD25/IL-2R alpha can be efficiently induced in primary human T cells since approximately 100% express this gene when ..
  6. Cavanillas M, Alcina A, Nunez C, De las Heras V, Fernandez Arquero M, Bartolome M, et al. Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk. Eur J Hum Genet. 2010;18:794-9 pubmed publisher
    ..The relevant role of the IL2RA gene on MS susceptibility adds support to its common effect on autoimmune risk and the suggestive association of IL2/IL21 warrants further investigation. ..
  7. Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, et al. Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Science. 1989;244:551-6 pubmed
    Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain...
  8. Lindqvist C, Christiansson L, Simonsson B, Enblad G, Olsson Stromberg U, Loskog A. T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignancies. Immunology. 2010;131:371-6 pubmed publisher
    ..It binds to the IL-2 receptor consisting of three chains, the ? (CD25), ? and common ? (?c)...
  9. Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature. 2010;466:113-7 pubmed publisher
    ..cells), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), interleukin (IL)-2/IL-21, IL-2 receptor A (IL-2RA; CD25) and Eos (also known as Ikaros family zinc finger 4; IKZF4), as well as the human leukocyte antigen (HLA) region...
  10. Prahalad S, Hansen S, Whiting A, Guthery S, Clifford B, McNally B, et al. Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis. Arthritis Rheum. 2009;60:2124-30 pubmed publisher
    ..Our results suggest that clinically distinct autoimmune phenotypes share common genetic susceptibility factors. ..
  11. Carr E, Clatworthy M, Lowe C, Todd J, Wong A, Vyse T, et al. Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis. BMC Med Genet. 2009;10:22 pubmed publisher
    ..Differential association of autoimmune diseases and SNPs within the IL2RA locus suggests that the IL2RA pathway may prove to play differing, as yet undefined, roles in each disease. ..
  12. Bonelli M, Savitskaya A, Steiner C, Rath E, Smolen J, Scheinecker C. Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus. J Immunol. 2009;182:1689-95 pubmed
    CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) that specialize in the suppression of immune responses might be critically involved in the pathogenesis of autoimmune diseases...
  13. Maier L, Anderson D, Severson C, Baecher Allan C, Healy B, Liu D, et al. Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol. 2009;182:1541-7 pubmed
    ..In summary, we propose that before disease onset, strong genetic factors associated with disease risk dictate sIL-2RA levels that may be further modulated with onset of chronic systemic inflammation associated with MS. ..
  14. Chistiakov D, Chistiakova E, Voronova N, Turakulov R, Savost anov K. A variant of the Il2ra?/?Cd25 gene predisposing to graves' disease is associated with increased levels of soluble interleukin-2 receptor. Scand J Immunol. 2011;74:496-501 pubmed publisher
    Alpha-subunit of the IL-2 receptor (IL-2R?) encoded by the IL2RA/CD25 gene binds IL-2 that plays a pivotal role in the regulation of T cell function...
  15. Pekalski M, Ferreira R, Coulson R, Cutler A, Guo H, Smyth D, et al. Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors. J Immunol. 2013;190:2554-66 pubmed publisher
    ..In this study we present evidence that the frequency of naive CD4 T cells that express CD25 (IL-2 receptor ?-chain) increases with age on subsets of both CD31(+) and CD31(-) naive CD4 T cells...
  16. Knevel R, de Rooy D, Zhernakova A, Grondal G, Krabben A, Steinsson K, et al. Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis. Arthritis Rheum. 2013;65:1684-93 pubmed publisher
    ..The present genetic and serologic data suggest that inherited altered genetic constitution at the IL2RA locus may predispose to a less destructive course of RA. ..
  17. Sharfe N, Dadi H, Shahar M, Roifman C. Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor. Proc Natl Acad Sci U S A. 1997;94:3168-71 pubmed a novel human immune aberration arising from a truncation mutation of the interleukin-2 receptor alpha chain (CD25), a subunit of the tripartite high-affinity receptor for interleukin 2...
  18. Matesanz F, Caro Maldonado A, Fedetz M, Fernandez O, Milne R, Guerrero M, et al. IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility. J Neurol. 2007;254:682-4 pubmed
  19. Lin B, Cross S, Halden N, Roman D, Toledano M, Leonard W. Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene. Mol Cell Biol. 1990;10:850-3 pubmed
    ..Thus, it is possible that both positive and negative elements may be important in the regulation of IL-2R alpha gene transcription. ..
  20. John S, Reeves R, Lin J, Child R, Leiden J, Thompson C, et al. Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins. Mol Cell Biol. 1995;15:1786-96 pubmed
  21. Matko J, Bodnar A, Vereb G, Bene L, Vámosi G, Szentesi G, et al. GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines. Eur J Biochem. 2002;269:1199-208 pubmed
    ..gamma(c) chains constitutively expressed in detergent-resistant membrane fractions (DRMs) of T cells, IL-2Ralpha (CD25) was also found in DRMs, independently of its ligand-occupation...
  22. Murakami S. Soluble interleukin-2 receptor in cancer. Front Biosci. 2004;9:3085-90 pubmed
    ..Serum sIL-2R is a useful parameter for evaluating the disease stage and monitoring the disease progression during the post-treatment follow-up, though it is not an organ-specific parameter. ..
  23. Vukmanovic Stejic M, Zhang Y, Cook J, Fletcher J, McQuaid A, Masters J, et al. Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest. 2006;116:2423-33 pubmed
    ..T lymphocytes were highly proliferative, with a doubling time of 8 days, compared with memory CD4+ CD45RO+ Foxp3- CD25- (24 days) or naive CD4+ CD45RA+ Foxp3- CD25- populations (199 days)...
  24. Fabre Guillevin E, Tabrizi R, Coulon V, Monnereau A, Eghbali H, Soubeyran I, et al. Aggressive non-Hodgkin's lymphoma: concomitant evaluation of interleukin-2, soluble interleukin-2 receptor, interleukin-4, interleukin-6, interleukin-10 and correlation with outcome. Leuk Lymphoma. 2006;47:603-11 pubmed
    ..However, sIL-2R and IL-6 measurements may improve risk assignment by IPI and allow a better prognostic evaluation of patients with intermediate prognosis NHL. ..
  25. Marquez A, Orozco G, Martinez A, Palomino Morales R, Fernandez Arquero M, Mendoza J, et al. Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease. Am J Gastroenterol. 2009;104:1968-75 pubmed publisher
    ..Our data agree with the effect previously observed for other conditions and delineate a shared underlying mechanism. ..
  26. Klinker M, Schiller J, Magnuson V, Wang T, Basken J, Veth K, et al. Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects. Immunogenetics. 2010;62:101-7 pubmed publisher
    ..These findings suggest that the IL2RA locus controls both the susceptibility to disease and its time of occurrence. Thus, we believe the IL2/IL2R axis represents a potential therapeutic target for delaying the onset of disease.
  27. Schaefer C, Kim G, Albers A, Hoermann K, Myers E, Whiteside T. Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer. Br J Cancer. 2005;92:913-20 pubmed
    ..The presence of CD4+CD25+ (Treg) cells in these patients might be, in part, responsible for downregulation of antitumour immune responses...
  28. Qu H, Verlaan D, Ge B, Lu Y, Lam K, Grabs R, et al. A cis-acting regulatory variant in the IL2RA locus. J Immunol. 2009;183:5158-62 pubmed publisher
  29. Vella A, Cooper J, Lowe C, Walker N, Nutland S, Widmer B, et al. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet. 2005;76:773-9 pubmed
    ..associated with type 1 diabetes (T1D), a common autoimmune disease, we tested the biological candidate gene IL2RA (CD25), which encodes a subunit (IL-2R alpha) of the high-affinity interleukin-2 (IL-2) receptor complex...
  30. Lindner E, Weger M, Steinwender G, Griesbacher A, Posch U, Ulrich S, et al. IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways?. Invest Ophthalmol Vis Sci. 2011;52:8295-9 pubmed publisher
    ..Recently, IL-2 receptor alpha (IL2RA, also called CD25) and IL-7 receptor alpha (IL7RA) gene variants (rs2104286, rs12722489, and rs6897932) have been identified to play ..
  31. Garg G, Tyler J, Yang J, Cutler A, Downes K, Pekalski M, et al. Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. J Immunol. 2012;188:4644-53 pubmed publisher
    Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous proinflammatory ..
  32. . Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet. 2009;41:824-8 pubmed publisher
    ..6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001). ..
  33. Wang J, Wicker L, Santamaria P. IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity. Semin Immunol. 2009;21:363-71 pubmed publisher
    ..Here, we summarize what we know about the genetics of T1D with an emphasis on the contributions of mouse Il2 and human IL2RA polymorphisms and the IL-2-IL-2R pathway to autoimmunity and, more specifically, Treg development and function. ..
  34. Strieder T, Drexhage H, Lam Tse W, Prummel M, Tijssen J, Wiersinga W. A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?. Autoimmunity. 2006;39:93-8 pubmed
    ..hyper- or hypothyroidism in whom we studied the percentages of circulating subsets of activated (MHC class-II, CD25 (IL-2R), CD71 or CD69+) CD4+ T cells and the level of the soluble (s)-IL2R in serum...
  35. Kim H, Imbert J, Leonard W. Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev. 2006;17:349-66 pubmed
    ..We now cover an under-reviewed area-the regulation of genes encoding IL-2 and IL-2R components, with an effort to integrate/explain this knowledge. ..
  36. Maier L, Lowe C, Cooper J, Downes K, Anderson D, Severson C, et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet. 2009;5:e1000322 pubmed publisher
    ..We demonstrate that multiple variants independently correlate with sIL-2RA levels. ..
  37. Leonard W, Depper J, Kanehisa M, Kronke M, Peffer N, Svetlik P, et al. Structure of the human interleukin-2 receptor gene. Science. 1985;230:633-9 pubmed
    ..Receptor gene transcription is initiated at two principal sites in normal activated T cells. Adult T cell leukemia cells infected with HTLV-I show activity at both of these sites, but also at a third transcription initiation site...
  38. Smyth D, Plagnol V, Walker N, Cooper J, Downes K, Yang J, et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med. 2008;359:2767-77 pubmed publisher
    ..These data suggest that common biologic mechanisms, such as autoimmunity-related tissue damage and intolerance to dietary antigens, may be etiologic features of both diseases. ..
  39. Weber F, Fontaine B, Cournu Rebeix I, Kroner A, Knop M, Lutz S, et al. IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations. Genes Immun. 2008;9:259-63 pubmed publisher
    ..1 to 1.5. The discovery and validation of new genetic risk factors in independent populations may help toward the understanding of MS pathogenesis by providing valuable information on biological pathways to be investigated. ..
  40. Lowe C, Cooper J, Brusko T, Walker N, Smyth D, Bailey R, et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet. 2007;39:1074-82 pubmed
    ..635). Furthermore, we have associated IL2RA T1D susceptibility genotypes with lower circulating levels of the biomarker, soluble IL-2RA (P = 6.28 x 10(-28)), suggesting that an inherited lower immune responsiveness predisposes to T1D. ..
  41. Qu H, Montpetit A, Ge B, Hudson T, Polychronakos C. Toward further mapping of the association between the IL2RA locus and type 1 diabetes. Diabetes. 2007;56:1174-6 pubmed
  42. Kahn Perles B, Lipcey C, Lecine P, Olive D, Imbert J. Temporal and subunit-specific modulations of the Rel/NF-kappaB transcription factors through CD28 costimulation. J Biol Chem. 1997;272:21774-83 pubmed
    ..dependent on persistent autocrine secretion of interleukin 2 (IL-2), high and prolonged expression of inducible CD25/IL-2 receptor alpha chain (IL-2Ralpha), and secretion of growth factors such as the granulocyte-macrophage colony-..
  43. Kim H, Kelly J, Leonard W. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements. Immunity. 2001;15:159-72 pubmed
    ..Thus, the IL-2 inducibility of the IL-2Ralpha gene is unexpectedly mediated by two widely separated regulatory Stat5-dependent elements, located both upstream and downstream of the transcription initiation sites. ..
  44. Verheijden K, Braber S, Leusink Muis T, Thijssen S, Boon L, Kraneveld A, et al. Regulatory T Cell Depletion Abolishes the Protective Effect of Dietary Galacto-Oligosaccharides on Eosinophilic Airway Inflammation in House Dust Mite-Induced Asthma in Mice. J Nutr. 2016;: pubmed
    ..Previously, CD25+ regulatory T cells (Tregs) induced by nondigestible oligosaccharides were found to protect against ..
  45. Declercq J, Ramos Molina B, Sannerud R, Brouwers B, Pruniau V, Meulemans S, et al. Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines. Eur J Cell Biol. 2017;96:432-439 pubmed publisher
    ..Stable cell lines overexpressing chimeric proteins (CD25 and CD46) containing the cytoplasmic domain of PC7 in which the basic cluster alone or together with both ..
  46. Vianna P, Mondadori A, Bauer M, Dornfeld D, Chies J. HLA-G and CD8+ regulatory T cells in the inflammatory environment of pre-eclampsia. Reproduction. 2016;152:741-751 pubmed
    ..PBMCs were phenotyped for early activation markers (CD25 and CD69), regulatory T-cell markers (CD8+CD28- and CD4+CD25highFoxp3<..
  47. Tsutsumi S, Nakajima S, Oda H, Yasumoto Y. Langerhans cell histiocytosis with seborrheic eczema of the scalp and extensive calvarial involvement. Childs Nerv Syst. 2016;32:1337-41 pubmed publisher
    ..A biopsy surgery confirmed the diagnosis as LCH. LCH may cause progressive calvarial defects. If seborrheic eczemas are concurrent, they may suggest prompt histological verification and treatments be initiated. ..
  48. Mitiushova E, Shatrova A, Zenin V, Aksenov N, Marakhova I. [The STAT5 signaling in the expression of alpha-subunit of interleukin-2 receptor in human blood lymphocytes]. Tsitologiia. 2013;55:421-9 pubmed
    ..expression of a α-subunit of interleukin-2 receptor (as examined by cytophotometric evaluation of the number of CD25+ cells) during the phytohemagglutinin (PHA)-induced proliferation of human blood lymphocytes (HBL) have been made...
  49. Jiao Y, Liu C, Luo L, Zhu W, Zhang T, Zhang L, et al. CD4+CD25+CD127 regulatory cells play multiple roles in maintaining HIV-1 p24 production in patients on long-term treatment: HIV-1 p24-producing cells and suppression of anti-HIV immunity. Int J Infect Dis. 2015;37:42-9 pubmed publisher
    ..CD4+CD25+CD127 regulatory cells play multiple roles in maintaining HIV-1 p24 production in long-term ART patients...
  50. Martínez González J, Martín Arés M, Martínez Rodríguez N, Barona Dorado C, Sanz Alonso J, Cortés Bretón Brinkmann J, et al. Comparison of peri-implant soft tissues in submerged versus transmucosal healing: A split mouth prospective immunohistochemical study. Arch Oral Biol. 2018;90:61-66 pubmed publisher
    ..approaches failed to identify statistically significant differences in CD19+ B cells, CD4+ T cells, CD8+ T cells, CD25+ T cells or γd T cells. However, significant differences in NK lymphocytes (p = 0...
  51. Umino K, Fujiwara S, Ikeda T, Toda Y, Ito S, Mashima K, et al. Prognostic value of the soluble interleukin-2 receptor level after patients with follicular lymphoma achieve a response to R-CHOP. Hematology. 2017;22:521-526 pubmed publisher
    ..001). Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis. ..
  52. Gupta A, Sachdeva M, Ahluwalia J, Das R, Naseem S, Sharma P, et al. Haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north India. Indian J Med Res. 2015;142:426-9 pubmed publisher
    ..Immunophenotyping showed expression of CD19, CD20, CD103, CD25 and CD11c in all cases, while positivity was seen for CD79b in 93...
  53. Landskron J, Tasken K. CD147 in regulatory T cells. Cell Immunol. 2013;282:17-20 pubmed publisher
    ..We recently reported its expression to high levels and association with suppressive function in regulatory T cells. Here, we discuss its potential application as a marker of activated regulatory T cells. ..
  54. Do H, Vasilescu A, Diop G, Hirtzig T, Coulonges C, Labib T, et al. Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort. Immunogenetics. 2006;58:89-98 pubmed
    ..This complete catalog of polymorphisms in IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFNgammaR1 cytokine receptor genes should also be useful for investigating associations in other immune-related diseases. ..
  55. Schwedhelm K, Thorpe J, Murray S, Gavin M, Speake C, Greenbaum C, et al. Attenuated IL-2R signaling in CD4 memory T cells of T1D subjects is intrinsic and dependent on activation state. Clin Immunol. 2017;181:67-74 pubmed publisher
    ..In T1D, low IL-2 responsiveness was most pronounced in memory Teff. Unlike Treg, CD25 expression did not influence the Teff responses...
  56. Hurabielle C, Sbidian E, Beltraminelli H, Bouchindhomme B, Chassagne Clement C, Balme B, et al. Eruption of lymphocyte recovery with atypical lymphocytes mimicking a primary cutaneous T-cell lymphoma: a series of 12 patients. Hum Pathol. 2018;71:100-108 pubmed publisher
    ..showed a dermal perivascular lymphocytic infiltrate containing atypical medium- to large-sized CD3+, CD4+ and CD8+, CD25+, ICOS+, PD1- lymphocytes with a strong CD30 expression in most instances (n=10), suggesting the recruitment of ..
  57. Yan B, Liu Y, Xie Q, Liu G. [Altered frequency of CD4+CD25-Foxp3+ T cells in patients with systemic lupus erythematosus]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25:695-8 pubmed
    To investigate the expression pattern of circulating CD4+CD25-Foxp3+ T cells from the patients with systemic lupus erythematosus (SLE) in order to explore their role in disease pathogenesis...
  58. Osusky M, Teschke L, Wang X, Wong K, Buckley J. A chimera of interleukin 2 and a binding variant of aerolysin is selectively toxic to cells displaying the interleukin 2 receptor. J Biol Chem. 2008;283:1572-9 pubmed
    ..The targeted channel-forming hybrid protein may have important advantages as a therapeutic agent. ..
  59. Kumar S, Wang J, Thomson A, Gandhi C. Hepatic stellate cells increase the immunosuppressive function of natural Foxp3+ regulatory T cells via IDO-induced AhR activation. J Leukoc Biol. 2017;101:429-438 pubmed publisher
    Immunosuppressive, naturally occurring CD4+CD25+forkhead box p3+ (Foxp3+) regulatory T cells (nTregs) offer potential for the treatment of immune-mediated inflammatory disorders...
  60. Baan C, Velthuis J, van Gurp E, Mol W, Klepper M, Ijzermans J, et al. Functional CD25(bright+) alloresponsive T cells in fully immunosuppressed renal allograft recipients. Clin Transplant. 2007;21:63-71 pubmed
    Evidence from animal studies indicate a crucial role for CD25(bright+) regulatory T cells in transplantation tolerance...
  61. Nakase K, Kita K, Kyo T, Tsuji K, Katayama N. High serum levels of soluble interleukin-2 receptor in acute myeloid leukemia: correlation with poor prognosis and CD4 expression on blast cells. Cancer Epidemiol. 2012;36:e306-9 pubmed publisher
    ..These results suggest that serum sIL-2R level elevates in acute type leukemias like mature type LD, and increased sIL-2R levels in adult AML are correlated with certain biological and clinical characteristics. ..
  62. Hernández Del Pino R, Pellegrini J, Rovetta A, Peña D, Álvarez G, Rolandelli A, et al. Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses. Immunol Cell Biol. 2017;95:716-728 pubmed publisher
    ..In low responder (LR) TB patients, impaired RICD was associated with diminished FASL levels, IL-2 production and CD25high expression after cell-restimulation...
  63. Zhao W, Ma Y, Wang M, Shi C, Sun J, Chu K, et al. Expression of Foxp3 in renal tissue of patients with HBV-associated glomerulonephritis and their clinical and pathological characteristics. Exp Ther Med. 2017;14:4928-4934 pubmed publisher
    ..Clinical manifestations, laboratory indices and renal biopsies were recorded. Expression of Foxp3, CD4 and CD25 in renal tissue was detected by immunohistochemistry. In group A, 74...
  64. Wang B, Wang X, Sun H, Hu L, Gao J. The effects of T helper 17 and regulatory T cells on patients with carotid atherosclerosis. Pak J Pharm Sci. 2017;30:1923-1928 pubmed
    This study was aimed to observe the level of T helper 17 (Th17) cells and CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) and their related factors in carotid atherosclerosis (AS) patients and AS model rats ..