CD25

Summary

Gene Symbol: CD25
Description: interleukin 2 receptor, alpha
Alias: CD25, IDDM10, IL2R, TCGFR, p55, IL-2 receptor subunit alpha, IL-2R subunit alpha, TAC antigen, interleukin-2 receptor subunit alpha
Species: human

Top Publications

  1. pmc Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
    Calliope A Dendrou
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Nat Genet 41:1011-5. 2009
  2. pmc Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function
    Garima Garg
    Department of Immunobiology, School of Medicine, King s College London, London SE1 9RT, United Kingdom
    J Immunol 188:4644-53. 2012
  3. pmc Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor
    N Sharfe
    Department of Pediatrics, University of Toronto, ON, Canada
    Proc Natl Acad Sci U S A 94:3168-71. 1997
  4. pmc Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo
    Ying Jin
    Human Medical Genetics Program, School of Medicine, University of Colorado, P O Box 6511, Mailstop 8300, Aurora, CO 80045, USA
    N Engl J Med 362:1686-97. 2010
  5. pmc T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignancies
    Camilla A Lindqvist
    Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Immunology 131:371-6. 2010
  6. pmc Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses
    Lisa M Maier
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 182:1541-7. 2009
  7. pmc Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors
    Marcin L Pekalski
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
    J Immunol 190:2554-66. 2013
  8. doi IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity
    Jinguo Wang
    Julia McFarlane Diabetes Research Centre JMDRC and Department of Microbiology and Infectious Diseases, Institute of Inflammation, Infection and Immunity, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Semin Immunol 21:363-71. 2009
  9. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
  10. pmc Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation
    Todd M Brusko
    Department of Pathology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 4:e7980. 2009

Detail Information

Publications361 found, 100 shown here

  1. pmc Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
    Calliope A Dendrou
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Nat Genet 41:1011-5. 2009
    ..to show that differences in surface expression of the human interleukin-2 (IL-2) receptor alpha (IL2RA, or CD25) protein are restricted to particular immune cell types and correlate with several haplotypes in the IL2RA region ..
  2. pmc Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function
    Garima Garg
    Department of Immunobiology, School of Medicine, King s College London, London SE1 9RT, United Kingdom
    J Immunol 188:4644-53. 2012
    Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous proinflammatory ..
  3. pmc Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor
    N Sharfe
    Department of Pediatrics, University of Toronto, ON, Canada
    Proc Natl Acad Sci U S A 94:3168-71. 1997
    ..here a novel human immune aberration arising from a truncation mutation of the interleukin-2 receptor alpha chain (CD25), a subunit of the tripartite high-affinity receptor for interleukin 2...
  4. pmc Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo
    Ying Jin
    Human Medical Genetics Program, School of Medicine, University of Colorado, P O Box 6511, Mailstop 8300, Aurora, CO 80045, USA
    N Engl J Med 362:1686-97. 2010
    ..Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases...
  5. pmc T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignancies
    Camilla A Lindqvist
    Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Immunology 131:371-6. 2010
    ..It binds to the IL-2 receptor consisting of three chains, the α (CD25), β and common γ (γc)...
  6. pmc Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses
    Lisa M Maier
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 182:1541-7. 2009
    ..In summary, we propose that before disease onset, strong genetic factors associated with disease risk dictate sIL-2RA levels that may be further modulated with onset of chronic systemic inflammation associated with MS...
  7. pmc Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors
    Marcin L Pekalski
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
    J Immunol 190:2554-66. 2013
    ..In this study we present evidence that the frequency of naive CD4 T cells that express CD25 (IL-2 receptor α-chain) increases with age on subsets of both CD31(+) and CD31(-) naive CD4 T cells...
  8. doi IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity
    Jinguo Wang
    Julia McFarlane Diabetes Research Centre JMDRC and Department of Microbiology and Infectious Diseases, Institute of Inflammation, Infection and Immunity, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Semin Immunol 21:363-71. 2009
    ..Here, we summarize what we know about the genetics of T1D with an emphasis on the contributions of mouse Il2 and human IL2RA polymorphisms and the IL-2-IL-2R pathway to autoimmunity and, more specifically, Treg development and function...
  9. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
    ..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
  10. pmc Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation
    Todd M Brusko
    Department of Pathology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 4:e7980. 2009
    b>CD25, a component of the IL-2 receptor, is important in T cell proliferation, activation induced cell death, as well as the actions of both regulatory (Treg) and effector (Teff) T cells...
  11. ncbi Risk alleles for multiple sclerosis identified by a genomewide study
    David A Hafler
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 357:851-62. 2007
    ..Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis...
  12. doi Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects
    Matthew W Klinker
    Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
    Immunogenetics 62:101-7. 2010
    ..These findings suggest that the IL2RA locus controls both the susceptibility to disease and its time of occurrence. Thus, we believe the IL2/IL2R axis represents a potential therapeutic target for delaying the onset of disease.
  13. pmc Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis
    Sampath Prahalad
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Arthritis Rheum 60:2124-30. 2009
    ....
  14. doi IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways?
    Ewald Lindner
    Department of Ophthalmology, General Hospital Klagenfurt, Austria
    Invest Ophthalmol Vis Sci 52:8295-9. 2011
    ..Recently, IL-2 receptor alpha (IL2RA, also called CD25) and IL-7 receptor alpha (IL7RA) gene variants (rs2104286, rs12722489, and rs6897932) have been identified to play ..
  15. pmc Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
    Lynn Petukhova
    Department of Dermatology, Columbia University, New York, New York 10032, USA
    Nature 466:113-7. 2010
    ..cells), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), interleukin (IL)-2/IL-21, IL-2 receptor A (IL-2RA; CD25) and Eos (also known as Ikaros family zinc finger 4; IKZF4), as well as the human leukocyte antigen (HLA) region...
  16. pmc IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D)
    Antonio Alcina
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Granada, Spain
    PLoS ONE 4:e4137. 2009
    IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity.
  17. ncbi Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's
    M Hatakeyama
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Science 244:551-6. 1989
    Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain...
  18. doi A variant of the Il2ra / Cd25 gene predisposing to graves' disease is associated with increased levels of soluble interleukin-2 receptor
    D A Chistiakov
    Department of Molecular Diagnostics, National Research Center GosNIIgenetika, Moscow, Russia
    Scand J Immunol 74:496-501. 2011
    Alpha-subunit of the IL-2 receptor (IL-2Rα) encoded by the IL2RA/CD25 gene binds IL-2 that plays a pivotal role in the regulation of T cell function...
  19. doi A cis-acting regulatory variant in the IL2RA locus
    Hui Qi Qu
    Endocrine Genetics Lab, The McGill University Health Center and Montreal Children s Hospital, Montreal, Quebec, Canada
    J Immunol 183:5158-62. 2009
    ....
  20. pmc Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis
    Edward J Carr
    Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0XY, UK
    BMC Med Genet 10:22. 2009
    ....
  21. doi Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease
    Ana Marquez
    Immunology Department, Hospital Clinico San Carlos, Madrid 28040, Spain
    Am J Gastroenterol 104:1968-75. 2009
    ..Therefore, we decide to investigate the association of polymorphisms in the IL-2 axis (IL2, IL2RA, and IL2RB genes) with inflammatory bowel diseases (IBDs)...
  22. pmc Binding of HMG-I(Y) imparts architectural specificity to a positioned nucleosome on the promoter of the human interleukin-2 receptor alpha gene
    R Reeves
    Biochemistry Biophysics, School of Molecular Biosciences, Washington State University, Pullman 99164, USA
    Mol Cell Biol 20:4666-79. 2000
    ..Together, these findings suggest a role for the HMG-I(Y) protein in assisting the remodeling of a critically positioned nucleosome on the PRRII promoter element during IL-2Ralpha transcriptional activation in lymphocytes in vivo...
  23. pmc IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production
    Lisa M Maier
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000322. 2009
    ..We demonstrate that multiple variants independently correlate with sIL-2RA levels...
  24. ncbi Toward further mapping of the association between the IL2RA locus and type 1 diabetes
    Hui Qi Qu
    Endocrine Genetics Laboratory, McGill University Health Center Montreal Children s Hospital, Montreal, Quebec, Canada
    Diabetes 56:1174-6. 2007
    ....
  25. ncbi Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus
    Michael Bonelli
    Division of Rheumatology, Internal Medicine III, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria
    J Immunol 182:1689-95. 2009
    CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) that specialize in the suppression of immune responses might be critically involved in the pathogenesis of autoimmune diseases...
  26. pmc Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 60:251-7. 2009
    IL2RA/CD25, the gene for interleukin-2 receptor alpha, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single-nucleotide ..
  27. pmc Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
    Milica Vukmanovic-Stejic
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, Windeyer Institute of Medical Sciences, University College London, London, United Kingdom
    J Clin Invest 116:2423-33. 2006
    ..T lymphocytes were highly proliferative, with a doubling time of 8 days, compared with memory CD4+ CD45RO+ Foxp3- CD25- (24 days) or naive CD4+ CD45RA+ Foxp3- CD25- populations (199 days)...
  28. ncbi Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs
    Oliver J Brand
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Clin Endocrinol (Oxf) 66:508-12. 2007
    ..identified genetic association between type 1 diabetes (T1D) and the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region on chromosome 10p15...
  29. ncbi Levels of circulating regulatory CD4+CD25+ T cells are decreased in breast cancer patients after vaccination with a HER2/neu peptide (E75) and GM-CSF vaccine
    Matthew T Hueman
    Clinical Breast Care Project, Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA
    Breast Cancer Res Treat 98:17-29. 2006
    ..We have investigated the impact of this vaccine on circulating levels of regulatory T cells (Treg) and the resulting effects on antitumor responses...
  30. ncbi Temporal and subunit-specific modulations of the Rel/NF-kappaB transcription factors through CD28 costimulation
    B Kahn-Perles
    Unité de Cancérologie Expérimentale, U119 INSERM, 27 Boulevard Lei Roure, 13009 Marseille, France
    J Biol Chem 272:21774-83. 1997
    ..dependent on persistent autocrine secretion of interleukin 2 (IL-2), high and prolonged expression of inducible CD25/IL-2 receptor alpha chain (IL-2Ralpha), and secretion of growth factors such as the granulocyte-macrophage colony-..
  31. pmc Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk
    María L Cavanillas
    Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Hum Genet 18:794-9. 2010
    ..The relevant role of the IL2RA gene on MS susceptibility adds support to its common effect on autoimmune risk and the suggestive association of IL2/IL21 warrants further investigation...
  32. ncbi Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
    Hyoung Pyo Kim
    Laboratory of Molecular Immunology, Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, United States
    Cytokine Growth Factor Rev 17:349-66. 2006
    ..We now cover an under-reviewed area-the regulation of genes encoding IL-2 and IL-2R components, with an effort to integrate/explain this knowledge...
  33. pmc Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene
    B B Lin
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    Mol Cell Biol 10:850-3. 1990
    ..Thus, it is possible that both positive and negative elements may be important in the regulation of IL-2R alpha gene transcription...
  34. ncbi IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility
    Fuencisla Matesanz
    J Neurol 254:682-4. 2007
  35. ncbi Structure of the human interleukin-2 receptor gene
    W J Leonard
    Science 230:633-9. 1985
    ..Receptor gene transcription is initiated at two principal sites in normal activated T cells. Adult T cell leukemia cells infected with HTLV-I show activity at both of these sites, but also at a third transcription initiation site...
  36. doi IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations
    F Weber
    Max Planck Institute of Psychiatry, Munich, Germany
    Genes Immun 9:259-63. 2008
    ..1 to 1.5. The discovery and validation of new genetic risk factors in independent populations may help toward the understanding of MS pathogenesis by providing valuable information on biological pathways to be investigated...
  37. pmc In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells
    M Algarte
    INSERM U119, Marseille, France
    EMBO J 14:5060-72. 1995
    ..b>CD25/IL-2R alpha can be efficiently induced in primary human T cells since approximately 100% express this gene when ..
  38. ncbi A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?
    Thea G A Strieder
    Academic Medical Center, University of Amsterdam, Department of Endocrinology, 1105 AZ, Amsterdam Zuidoost, The Netherlands
    Autoimmunity 39:93-8. 2006
    ..hyper- or hypothyroidism in whom we studied the percentages of circulating subsets of activated (MHC class-II, CD25 (IL-2R), CD71 or CD69+) CD4+ T cells and the level of the soluble (s)-IL2R in serum...
  39. ncbi Soluble interleukin-2 receptor in cancer
    Saburo Murakami
    Department of Surgery, Saitama Medical School, Morohongo 38, Moyorama machi, Iruma gunn, Saitama, 350 0495, Japan
    Front Biosci 9:3085-90. 2004
    ..Serum sIL-2R is a useful parameter for evaluating the disease stage and monitoring the disease progression during the post-treatment follow-up, though it is not an organ-specific parameter...
  40. pmc Altered interleukin-2 receptor alpha-chain is expressed in human T-cell leukaemia virus type-I-infected T-cell lines and human peripheral blood mononuclear cells of adult T-cell leukaemia patients through an alternative splicing mechanism
    S Horiuchi
    Department of Microbiology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    Immunology 91:28-34. 1997
    ..Our results indicate that an altered IL-2R alpha chain is expressed in HTLV-I-infected T lymphocytic cell lines and in ATL patients...
  41. pmc Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins
    S John
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892
    Mol Cell Biol 15:1786-96. 1995
    ....
  42. ncbi Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    Christopher E Lowe
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, UK
    Nat Genet 39:1074-82. 2007
    ..635). Furthermore, we have associated IL2RA T1D susceptibility genotypes with lower circulating levels of the biomarker, soluble IL-2RA (P = 6.28 x 10(-28)), suggesting that an inherited lower immune responsiveness predisposes to T1D...
  43. pmc Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms
    Adrian Vella
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Hum Genet 76:773-9. 2005
    ..associated with type 1 diabetes (T1D), a common autoimmune disease, we tested the biological candidate gene IL2RA (CD25), which encodes a subunit (IL-2R alpha) of the high-affinity interleukin-2 (IL-2) receptor complex...
  44. ncbi Modulating effects on CD25 and CD71 antigen expression by lectin-stimulated T lymphocytes in the elderly
    S Antonaci
    University of Bari Medical Faculty, Italy
    Immunopharmacol Immunotoxicol 13:87-100. 1991
    ..aged peripheral blood mononuclear cells (PBMC) were stimulated with phytohemagglutinin (PHA) and assessed for CD25 (IL-2 receptor) and CD71 (transferrin receptor) expression at different intervals of time...
  45. ncbi Halothane inhibits T cell proliferation and interleukin-2 receptor expression in rats
    J G Hamra
    Department of Anesthesiology, University of California, San Diego, LaJolla 92093-0818, USA
    Immunopharmacol Immunotoxicol 18:323-36. 1996
    ..The ability of T lymphocytes to express both the CD8 and CD25 (IL-2) receptors in response to PHA were suppressed...
  46. ncbi Immunohistochemical demonstration of subclasses of inflammatory cells and active, collagen-producing fibroblasts in the synovial plicae of lumbar facet joints
    Y T Konttinen
    Fourth Department of Medicine, University of Helsinki, Central Hospital, Finland
    Spine (Phila Pa 1976) 15:387-90. 1990
    ....
  47. ncbi Defective expression of IL-2 receptors on peripheral blood lymphocytes from patients with cluster headache
    P Martelletti
    Headache Centre, , Rome, Italy
    Headache 30:228-31. 1990
    ..ml) and after 72 hours. The following Becton Dickinson MAbs have been used: anti-Leu-4 (CD3), anti-IL-2 receptors (CD25), anti-Transferrin receptor (TFR) and anti-Leu-11b (CD16)...
  48. ncbi [The serum level of the secreted interleukin 2 receptor (sIL-2R): a lymphocyte activity parameter in sarcoidosis]
    J Muller-Quernheim
    III Med Klinik Schwerpunkt Pneumologie, Universitätskliniken Mainz
    Pneumologie 44:213-4. 1990
    ....
  49. ncbi [Monitoring sarcoidosis therapy with immunopathologic parameters]
    J Muller-Quernheim
    III Med Klinik, Schwerpunkt Pneumologie, Johannes Gutenberg Universitat, Mainz
    Pneumologie 48:47-9. 1994
    ..Bronchoalveolar lavage yields different cytological patterns typical for the acute and chronic forms of the disease permitting the identification of the subpopulation on risk for functional deterioration...
  50. ncbi [Serum adenosine deaminase as a parameter for activity in sarcoidosis]
    E Wetzel
    Krankenanstalt, , Akademisches Lehrkrankenhaus,
    Pneumologie 53:323-8. 1999
    ..In comparison to the other parameters, measurement of the serum ADA indicates a greater discrimination between active and inactive disease...
  51. ncbi Peripheral blood and tumor infiltrating lymphocytes in non-small cell lung cancer: analysis at the population and clonal level
    M Viale
    Istituto Nazionale per la Ricerca sul Cancro, Laboratorio di Farmacologia, Genova, Italy
    Tumori 76:488-94. 1990
    ..Differences were found in the expression of CD25 (IL-2 receptor) and DR (MHC class II) antigens, which were increased in TILs, and in the percentage of CD16+ ..
  52. ncbi Evaluation of cellular immune responses and soluble mediators in patients with chronic hepatitis C virus (cHCV) infection
    E Jirillo
    Faculty of Medicine, University of Bari, Italy
    Immunopharmacol Immunotoxicol 17:347-64. 1995
    ..In conclusion, the overall results indicate a condition of peripheral immune depression in cHCV patients with an exaggerated shedding of various mediators endowed with noxious effects for the host...
  53. ncbi Serum levels of interleukins 2, 6 and 8, soluble interleukin-2 receptor and intercellular adhesion molecule-1 during treatment with interleukin-2 plus interferon-alfa
    M S Vuoristo
    Department of Oncology, Tampere University Hospital, Finland
    Immunopharmacol Immunotoxicol 18:337-54. 1996
    ..Thus, no definite conclusions could be drawn. However, it seems worthwhile to measure IL-2, sIL-2R and sICAM-1 during immunotherapy; their prognostic value should be further evaluated in a larger patient population...
  54. ncbi Re-infection in human schistosomiasis mansoni: a prospective field study 18 months after praziquantel therapy
    K Zwingenberger
    , Berlin
    Ann Trop Med Parasitol 84:457-65. 1990
    ..The results indicate a dissociation of factors regulating fibrogenesis and immunomodulation after treatment and re-infected...
  55. ncbi Circulating soluble IL-2 receptor levels are low in patients with hypothyroid autoimmune thyroiditis
    A Loviselli
    Institute of Internal Medicine, University of Cagliari, Italy
    Horm Metab Res 26:548-51. 1994
    ..They also suggest that the measurement of soluble Interleukin 2 receptors could be used as a marker of the peripheral action of thyroid hormones...
  56. ncbi Garlic extracts stimulate proliferation of rat lymphocytes in vitro by increasing IL-2 and IL-4 production
    M Colic
    Institute of Medical Research, Military Medical Academy, Belgrade, Yugoslavia
    Immunopharmacol Immunotoxicol 22:163-81. 2000
    ..These results suggest that the potentiating effect of garlic extracts on lymphocyte proliferation in vitro differs depending on specific stimulators of cell proliferation and probably on the type of responding cells...
  57. ncbi Immunotoxicity of cocaethylene
    F Chiappelli
    Laboratory of Human Oral and Molecular Immunology, UCLA School of Dentistry 90024-1668, USA
    Immunopharmacol Immunotoxicol 17:399-417. 1995
    ....
  58. ncbi Analysis of interleukin-2/interleukin-2 receptor system in advanced non-small-cell lung cancer
    F De Vita
    Department of Internal and Experimental Medicine F. Magrassi, II University of Naples, Italy
    Tumori 84:33-8. 1998
    ..Circulating CD25+ cells were analyzed by flow cytoflorimetry...
  59. ncbi [Study on cellular immunity in children with respiratory syncytial virus associated acute lower respiratory infection]
    Z Chen
    Department of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan 430030
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:263-6. 1997
    ..These results suggested that human body had a functional disturbance in cellular immunity when infected with RSV...
  60. ncbi Increased level of soluble interleukin-2 receptor in advanced solid tumors: a preliminary study
    F Rovelli
    Laboratorio di Radioimmunologia, Ospedale San Gerardo, Milano, Italia
    Tumori 74:633-7. 1988
    ..Further studies will be needed to establish if elevated concentrations of IL-2R in the serum can contribute to the immunoincompetence of patients with disseminated solid neoplasms...
  61. ncbi Modulation of the interleukin 2 receptor by maternal and cord blood serum
    Y E Vanderbeeken
    Department of Immunology, Hospital St-Pierre, Brussels, Belgium
    Immunopharmacol Immunotoxicol 12:211-36. 1990
    ..inhibitive action, of maternal serum (retroplacental and peripheral), and cord blood serum on the expression of the Il2r has been studied. Calf and male serum were used as a control...
  62. ncbi Interleukin-2 receptor levels in non-Hodgkin's lymphoma. Correlation to histological degree of malignancy and presence of constitutional symptoms
    J M Tangen
    Department of Oncology, , Oslo, Norway
    Acta Oncol 29:581-3. 1990
    ..All three parameters should therefore be taken into account when the clinical significance of Il-2R levels is evaluated...
  63. ncbi Immunoendocrine aspects of major depression. Relationships between plasma interleukin-6 and soluble interleukin-2 receptor, prolactin and cortisol
    M Maes
    CRC-MH, Department of Psychiatry, AZ Stuivenberg, Antwerp, Belgium
    Eur Arch Psychiatry Clin Neurosci 245:172-8. 1995
    ..There were also significant positive correlations between plasma prolactin and sIL-2R concentrations in major depressed subjects and in the combined groups of normal and major depressed subjects...
  64. ncbi Soluble interleukin-2 receptor levels in patients with malignant melanoma and renal cell cancer
    B Ostenstad
    Institute of Immunology and Rheumatology, Oslo, Norway
    Acta Oncol 31:413-5. 1992
    ..sIL-2R is possibly a marker of the host immune response to the tumour, but further investigations are needed to see if it has any predictive value concerning prognosis or response to immune therapy...
  65. ncbi Serum soluble interleukin-2 receptor in colorectal cancer
    S Murakami
    Second Department of Surgery, Saitama Medical School, Japan
    Acta Oncol 33:19-21. 1994
    ..Preoperative serum IL-2R levels thus seem to reflect the stage of the disease...
  66. ncbi Mitoxantrone as a single agent in pretreated metastatic breast cancer: effects on T lymphocyte subsets and their relation to clinical response
    S Barni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy
    Tumori 77:227-31. 1991
    ..T suppressor cells (CD8+/CD57+), T cytotoxic cells (CD8+/CD57-), NK (CD16) and IL-2 receptor-expressing cells (CD25) were also measured at the same time...
  67. ncbi Sodium arsenite reduces proliferation of human activated T-cells by inhibition of the secretion of interleukin-2
    L Vega
    , UNAM, ,
    Immunopharmacol Immunotoxicol 21:203-20. 1999
    ..In order to understand the mechanism of this suppression, the effect of As was evaluated on the expression of CD25, and IL-2 secretion in human peripheral blood mononuclear cells (PBMC)...
  68. ncbi Possible correlation between some biologic effects and the clinical course in patients treated with continuous infusion of interleukin-2 plus alpha-2 interferon for metastatic renal cell carcinoma
    C Baiocchi
    Divisioni Oncologia Medica Falck, , Milano, Italy
    Tumori 80:348-52. 1994
    ..Some of our patients showed a significant increase in eosinophils, CD25+ lymphocytes and antithyroid antibodies...
  69. ncbi Immunological alterations associated with Plasmodium vivax malaria in South Korea
    H K Lee
    Department of Clinical Pathology, College of Medicine, Catholic University of Korea, 62 Youido dong, Youngdeungpo gu, Seoul, 150 713, South Korea
    Ann Trop Med Parasitol 95:31-9. 2001
    ..e. CD3+, CD8+, CD19+, CD56+, CD3-/CD56+ and CD8+/CD56+ but not CD4+, CD3+/CD56+ or CD25+] were significantly less common among the lymphocytes of patients at diagnosis than among those of the controls...
  70. ncbi Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low
    B Hausen
    Transplantation Immunology, Department of Cardiothoracic Surgery, Stanford University, Palo Alto, California 94305, USA
    Transplantation 69:488-96. 2000
    ..CsA and high-dose SDZ RAD (CTL group) to triple therapy using the chimeric anti-interleukin-2 (IL-2) receptor (CD25) monoclonal antibody (mAb) basiliximab (anti-IL-2 receptor mAb) for induction therapy (basiliximab: 5 mg ..
  71. ncbi Successful in vivo blockade of CD25 (high-affinity interleukin 2 receptor) on T cells by administration of humanized anti-Tac antibody to patients with psoriasis
    J G Krueger
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10021 6399, USA
    J Am Acad Dermatol 43:448-58. 2000
    Daclizumab is a humanized antibody to the alpha-subunit (CD25) of the interleukin 2 (IL-2) receptor that blocks normal IL-2 binding to this receptor...
  72. ncbi Comparison of the prevalence of inflammatory cells in subtypes of disc herniations and associations with straight leg raising
    J Virri
    Department of Orthopaedics, University of Helsinki, Finland
    Spine (Phila Pa 1976) 26:2311-5. 2001
    ..Monoclonal antibodies to T cells in general (CD2), activated T cells (CD25), B cells (CD22), and macrophages (CD68) were used...
  73. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
    ..CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules...
  74. ncbi Functional responses of T cells blocked by anti-CD25 antibody therapy during cardiac rejection
    C C Baan
    Department of Internal Medicine I, University Hospital Rotterdam Dijkzigt, The Netherlands
    Transplantation 69:331-6. 2000
    Despite anti-CD25 (interleukin [IL]-2 receptor alpha chain) monoclonal antibody (mAb) therapy, rejection can still occur...
  75. ncbi [Expression of regulatory T cells and related cytokines in mice allogenic corneal transplantation rejection]
    Xin Wang
    Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, China
    Zhonghua Yan Ke Za Zhi 45:1118-26. 2009
    To study the changes of CD4(+)CD25(+) and CD8(+)CD103(+) regulatory T cells and their relevant cytokines in corneal allograft transplantation in mice.
  76. doi Generation of Affibody ligands binding interleukin-2 receptor alpha/CD25
    Caroline Grönwall
    Department of Molecular Biotechnology, School of Biotechnology, AlbaNova University Center, Royal Institute of Technology KTH, SE 106 91 Stockholm, Sweden
    Biotechnol Appl Biochem 50:97-112. 2008
    Affibody molecules specific for human IL-2Ralpha, the IL-2 (interleukin-2) receptor alpha subunit, also known as CD25, were selected by phage-display technology from a combinatorial protein library based on the 58-residue Protein A-..
  77. ncbi Dysregulated expression of CD69 and IL-2 receptor alpha and beta chains on CD8+ T lymphocytes in flaky skin mice
    N J Abernethy
    Genesis Research and Development Corporation Limited, Auckland, New Zealand
    Immunol Cell Biol 78:596-602. 2000
    ..the present study, the expression of the inducible T-cell activation antigens CD69 and IL-2 receptor alpha chain (CD25) on PLN cells from fsn/fsn mice and their phenotypically normal littermates is examined...
  78. doi Immunohistochemical assessment of CD25 is equally sensitive and diagnostic in mastocytosis compared to flow cytometry
    C Baumgartner
    Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 38:326-35. 2008
    ..In most cases, the bone marrow is involved. Expression of CD25 in bone marrow MC, with or without coexpression of CD2, is an important minor SM criterion...
  79. ncbi Anti-CD25 mAb, anti-IL2 mAb, and IL2 block tolerance induction through anti-CD154 mAb and rapamycin in xenogeneic islet transplantation
    H Pan
    Department of General Surgery West China Hospital, Si Chuan University, Chengdu, Sichuan, China
    Transplant Proc 39:3452-4. 2007
    ..The aim of this study was to investigate whether classical anergy and/or regulation by interleukin (IL)2-dependent CD25+ T regulatory cells played roles in the induction and maintenance of tolerance in this model.
  80. ncbi [Changes of regulatory T cell number in hepatocellular carcinoma-bearing mice and its relationship with tumor growth]
    Pin Zhang
    Institute of Immunology, Medical School of Shandong University, Jinan 250012, China
    Zhonghua Zhong Liu Za Zhi 29:342-5. 2007
    ..To study the relationship between the change of regulatory T cell number in CD4+ T subset and the growth of tumor in H22 hepatocellular carcinoma-bearing mice...
  81. ncbi Interleukin-2 blocks the antitumour activity caused by depletion of CD25 cells in a murine renal adenocarcinoma model
    Takumi Takeuchi
    Department of Urology, Faculty of Medicine, University of Tokyo, Japan
    BJU Int 94:171-6. 2004
    To test the effectiveness of antimouse CD25 monoclonal antibody (mAb) against murine renal adenocarcinoma (RENCA) cells, as immunoregulatory/suppressor cells are known to be involved in tumour development in vivo, but the functions of ..
  82. ncbi Adoptive transfusion of ex vivo donor alloantigen-stimulated CD4(+)CD25(+) regulatory T cells ameliorates rejection of DA-to-Lewis rat liver transplantation
    Li Yong Pu
    Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Surgery 142:67-73. 2007
    ..In this study, we examined the therapeutic potential of CD4(+)CD25(+) Treg cells in a naive rejection model of rat liver transplantation.
  83. ncbi Mechanism of action of maternal serum on the interleukin2 receptor expression
    Y E Vanderbeeken
    Service d'Immunologie, , Brussels, Belgium
    Immunopharmacol Immunotoxicol 14:491-513. 1992
    ..The Il2R expression was significantly downregulated among maternal serum treated cells...
  84. ncbi Immunosuppression for neural xenografts: a comparison of cyclosporin and anti-CD25 monoclonal antibody
    C R Honey
    Division of Neurosurgery, University of British Columbia, Vancouver, Canada
    J Neurosurg 91:109-13. 1999
    ..was to compare the effects of short- and long-term immunosuppression induced by cyclosporin with those of immunosuppression induced by a monoclonal antibody against the rat interleukin-2 receptor (anti-CD25 mAb) in rats with xenografts.
  85. doi Induction of inducible CD4+CD25+Foxp3+ regulatory T lymphocytes by porcine reproductive and respiratory syndrome virus (PRRSV)
    P Wongyanin
    Interdisciplinary Program of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand
    Vet Immunol Immunopathol 133:170-82. 2010
    ..Recently, the existence of porcine CD4(+)CD25(+) Tregs has been demonstrated. We investigated the effect of PRRSV on the CD4(+)CD25(+) Tregs...
  86. ncbi [Inhibition of CD4+ CD25+ regulatory T cells in chronic hepatitis B patients]
    Heng Hui Zhang
    Hepatology Institute, People s Hospital, Peking University, Beijing, China
    Zhonghua Yi Xue Za Zhi 88:511-5. 2008
    To evaluate the inhibition of CD4+ CD25+ regulatory T cells (Treg) in the chronic hepatitis B patients.
  87. ncbi [Effect of apoptosis of CD4+ CD25+ regulatory T lymphocytes on polarization of helper T lymphocytes and potential interventional influence of Xuebijing injection in septic rats]
    Xin gui Dai
    Intensive Care Unit, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:135-8. 2009
    To evaluate the influence of apoptosis of CD4(+)CD25(+) regulatory T lymphocyte (Treg) on polarization of helper T lymphocyte (Th) and effect of Xuebijing injection in septic rats.
  88. ncbi Impact of CD4+CD25high regulatory T-cells and FoxP3 expression in the peripheral blood of patients with systemic lupus erythematosus
    Maha Atfy
    Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt
    Egypt J Immunol 16:117-26. 2009
    ..Regulatory T cells (Tregs) CD4+CD25+ play an important role in maintaining tolerance to self-antigens controlling occurrence of autoimmune diseases...
  89. ncbi CD4+CD25+ regulatory T lymphocytes in malignant pleural effusion
    Yi Qiang Chen
    Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, P R China
    Am J Respir Crit Care Med 172:1434-9. 2005
    Active suppression by CD4(+)CD25(+) regulatory T lymphocytes plays an important role in the downregulation of T-cell responses to foreign and self-antigens.
  90. doi Simultaneous blockade of costimulatory signals CD28-CD80 and CD40-CD154 combined with monoclonal antibody against CD25 induced a stable chimerism and tolerance without graft-versus-host disease in rat
    Z X Zhu
    Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai, PR China
    Eur Surg Res 46:109-17. 2011
    ..Our aim was to explore a nontoxic strategy for the induction of mixed chimerism by pretreatment with anti-CD25 monoclonal antibody (mAb), cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin (CTLA4Ig) and anti-CD154 mAb.
  91. ncbi Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4+CD25- T lymphocytes
    Emilie Brillard
    INSERM U645, University of Franche Comte, EFS Bourgogne Franche Comte, Besancon, France
    Exp Hematol 35:416-25. 2007
    CD4(+)CD25(+) regulatory T lymphocytes (Treg) have been initially shown to prevent organ-specific autoimmunity. It is now accepted that Treg homeostasis depends in part on the peripheral conversion of naïve CD4(+)CD25(-) T cells...
  92. doi Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa
    Suzana Radulovic
    Department of Upper Respiratory Medicine, Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital London, London, United Kingdom
    J Allergy Clin Immunol 121:1467-72, 1472.e1. 2008
    Regulatory T (Treg) cells play an important role in controlling allergic inflammation. The transcription factor Foxp3 regulates the development and function of natural and adaptive CD4(+)CD25(+) Treg cells.
  93. doi Role for CD4(+)CD25(+) T cells in inhibition of graft rejection by extracorporeal photopheresis
    James F George
    Department of Surgery, University of Alabama at Birmingham, AL 35294, USA
    J Heart Lung Transplant 27:616-22. 2008
    ..We created a mouse model of ECP to determine the effects of ECP on T-cell responses in vivo and the contribution of CD4(+)CD25(+) T cells.
  94. ncbi Regulation of transplant arteriosclerosis by CD25+CD4+ T cells generated to alloantigen in vivo
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Transplantation 83:1459-65. 2007
    b>CD25+CD4+ regulatory T cells have been shown to suppress alloimmunity in various experimental settings. Here, we hypothesized that alloantigen-reactive regulatory T cells would reduce the severity of transplant arteriosclerosis.
  95. ncbi Functional role of CD4+CD25+ regulatory T cells and transforming growth factor-beta1 in childhood immune thrombocytopenic purpura
    Nehal M A Fahim
    Department of Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Egypt J Immunol 13:173-87. 2006
    CD4+CD25+ regulatory T cells (Tregs) are critical in maintaining self tolerance and preventing organ specific autoimmune diseases...
  96. doi Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regulatory T cells in patients with active systemic lupus erythematosus
    Ram Kumar Chowdary Venigalla
    University of Heidelberg, Heidelberg, Germany
    Arthritis Rheum 58:2120-30. 2008
    ..The presence of many in vivo-preactivated CD4+,CD25++ T cells in patients with systemic lupus erythematosus (SLE) poses a difficulty in discriminating CD25++ activated ..
  97. ncbi Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells
    Jo Harnaha
    Department of Pathology, University of Pittsburgh School of Medicine, Diabetes Institute, Rangos Research Center, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA
    Diabetes 55:158-70. 2006
    ..demonstrate that immunoregulatory dendritic cells (iDCs) confer immune hyporesponsiveness in part through CD4(+) CD25(+) T regulatory cells (Tregs)...
  98. ncbi [Combination of CD4+ CD25+ regulatory T cell and costimulatory pathway blockade inhibits acute rejection after liver transplantation: experiment with rats]
    Liu Bin Shi
    Department of Transplantation, Huashan Hospital, Fudan University, Shanghai 200040, China
    Zhonghua Yi Xue Za Zhi 87:942-6. 2007
    To investigate the effect of CD4+ CD25+ regulatory T cell (Treg) combined with anti-CD154 mAb, a costimulatory pathway inhibitor, on acute rejection after liver transplantation.
  99. ncbi [Immunoregulatory role of 1, 25-dihydroxyvitamin D(3)-treated dendritic cells in allergic airway inflammation]
    Jun Bo Xia
    Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
    Zhonghua Yi Xue Za Zhi 89:514-8. 2009
    ..To explore the mechanism and immunoregulatory role of 1, 25-dihydroxy vitamin D(3) [1, 25 (OH)(2)D(3)]-treated dendritic cells (DCs) in allergic airway inflammation...
  100. ncbi [Suppressive effect of induced CD4+CD25+ regulatory T cells from mice infected with Schistosoma japonicum]
    Ming Juan Tan
    Department of Pathogen Biology, Nanjing Medical University, Nanjing 210029, China
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 26:166-9, 173. 2008
    To investigate the suppressive effect of CD4+CD25+ regulatory T cells from mice infected with Schistosoma japonicum.

Research Grants67

  1. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
    ..The BMT/CTN including our consortium will be the only clinical cooperative group to accomplish this goal. ..
  2. The IL-2 receptor in T regulatory cell development
    Thomas R Malek; Fiscal Year: 2012
    ..It is now appreciated that signaling through IL2R is mandatory for Treg cells...
  3. Role of MEK1 in T cell function in asthma
    Rafeul Alam; Fiscal Year: 2013
    ..We will examine genetically modified mouse strains and/or T cells, and an anti-IL2 receptor (anti-CD25) antibody for their effect on airway hyperreactivity, inflammation, mucus production and airway remodeling in this ..
  4. Homing and Homeostasis of Regulatory T cells
    Daniel J Campbell; Fiscal Year: 2012
    ..TR were initially identified by their constitutive expression of the high affinity IL-2 receptor component CD25, and IL-2 is required for proper TR function in vivo...
  5. Cytokines in T Regulatory Cell Function
    James W Verbsky; Fiscal Year: 2013
    ..We have shown that a patient lacking CD25, the high affinity IL-2 receptor, exhibits an autoimmune disease similar to patients lacking Foxp3...
  6. T1D:Investigating the Gut Microbiome, Urinary Proteome and Metabolome
    Ramana Madupu; Fiscal Year: 2011
    ..We propose to study the complex interplay of environmental, immunological and genetic factors to discover molecular signatures with a potential to advance clinical diagnosis and therapy at or before the onset of T1D. ..
  7. Bridging Pediatric and Adult Biomarkers of Graft-Versus-Host-Disease
    Jamie L Renbarger; Fiscal Year: 2013
    ..Ultimately, we propose the discovery of a GVHD-specific drug to increase efficacy and lower toxicity. ..
  8. Development of Intestinal Immune Regulation in Human Infants
    JOERN HENDRIK WEITKAMP; Fiscal Year: 2013
    ..are professional immune suppressor cells that are typically characterized as interleukin-2 receptor a (IL-2Ra = CD25)''"3'''CD4^ CD45RO* IL-7R (CD127)*"'T cells expressing high levels of the ..
  9. Regulatory T Cell-Deficient Mouse Model Rapidly Develops Sjogren's Syndrome
    Shyr Te Ju; Fiscal Year: 2010
    ..This study should identify new and useful models for Sjogren's syndrome research. It should identify new mechanism(s) for the pathogenesis of the disease and provide potential treatment of the disease. ..
  10. IMMUNOREGULATION OF ERYTHROPOIESIS
    Lee Levitt; Fiscal Year: 1992
    ..activity (BPA) from resting T cell and NK cells A 70KD IL2R has been identified in the absence of Tac antigen on resting T and NK cells. GM-CSF and IL3 have potent BPA...
  11. DESIGN OF MULTIMERIC INTERLEUKIN-2 RECEPTOR ECTODOMAINS
    Thomas Ciardelli; Fiscal Year: 2000
    ..4. To obtain detailed structure-activity data on these complexes by co-crystallizing them with IL-2 and determining their X-ray structures to high resolution. ..
  12. REGULATORY MECHANISMS IN HUMAN NATURAL CYTOTOXICITY
    Takashi Makinodan; Fiscal Year: 1990
    ..This results in (a) increased IL2 receptor (IL2R) affinity and/or increased numbers of IL2R/ cell and/or increased numbers of cells with IL2R; and (b) increased IL2 ..
  13. ROLE OF IL2 RECEPTOR POSITIVE CELLS IN TRANSPLANTATION
    Nicholas Tilney; Fiscal Year: 1991
    ..The role of activated leukocytes developing receptors for interleukin 2 (IL2R+ cells) in rejection will be emphasized, and their modulation by various IL2R targeted therapies assessed, a novel ..
  14. SPOTTED FEVER RICKETTSIAL ANTIGENS
    David H Walker; Fiscal Year: 2013
    ..by remarkable suppression of lymphocyte proliferation and IL-2 and IFN-gamma production by IL-10 producing CD4+CD25+ T regulatory cells in acute fatal murine spotted fever rickettsiosis compared to self-limited infection...
  15. Phase-I-II Study of DAB389 (ONTAK) in Patients with Adv. Refractory Breast Cancer
    Lupe Salazar; Fiscal Year: 2007
    ..to direct the cytocidal action of DT to malignant cells that express the high affinity form of the IL-2 receptor (CD25) while minimizing damage to normal cells that do not express the receptor...
  16. Therapeutic immune mechanisms of daclizumab in psoriasis
    James Krueger; Fiscal Year: 2004
    ..b>CD25 is the a-subunit of the IL-2R that is expressed selectively on activated T cells and dendritic antigen presenting ..
  17. Biology and Function of anti-HSV CD8 T Cells
    Stephen Jennings; Fiscal Year: 2007
    ..ability to express CTL function was intimately linked with the increased expression of the IL-2 receptor c_-chain, CD25. This observation lead to the conclusion that expression of high levels of CD25 was mandatory for the expression of ..
  18. Immunity to Ehrlichial Infections
    Nagaraja Ramavadhani Thirumalapura; Fiscal Year: 2013
    ..Further the study indicated that persistent E. muris infection induces expansion of CD4+CD25+ T regulatory cells and enhanced production of TGF-[unreadable]1 in the spleen, which may facilitate ehrlichial ..
  19. Characterization of Human Regulatory T cell-induced Dendritic Cells
    MICHAEL ALONSO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): CD4+CD25+Foxp3+ T regulatory cells (Tregs) and dendritic cells (DCs) are central to the immunosuppressive environment characteristic of many types of cancer including breast cancer...
  20. Immune Response to Cat: Regulatory and Effector T Cells
    Judith A Woodfolk; Fiscal Year: 2013
    ..Low expression of CD127 (IL-7R 1 chain) will be used to isolate natural (CD25+CD127lo) and adaptive (CD25negCD127lo) Tregs from AD patients...
  21. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    GREGORY TODD PHARR; Fiscal Year: 2010
    ..Treg cells will be identified in placental sections by immunofluorescent labeling with antibodies to CD4, CD25, and FoxP3. Confocal microscopy will be used to quantify these cells...
  22. Role of Memory T Cells in Pathogenesis and Resolution of Inflammatory Diseases
    Richard B Bankert; Fiscal Year: 2010
    ..nasal polyp tissues expand progressively following their implantation into severely immunocompromised NOD/SCID/IL2Rγnull mice, the contributions of lymphocytes and monocytes (and the biologically active factors they ..
  23. Interleukin-2 and autoimmune disease
    Abul K Abbas; Fiscal Year: 2012
    ..immune dysregulation and systemic autoimmunity because the obligatory function of this cytokine is to maintain CD4+ CD25+ FoxP3+ regulatory T-lymphocytes (Treg)...
  24. Control of Treg Homeostasis and Function by the Lipid Phosphatase PTEN
    Laurence A Turka; Fiscal Year: 2013
    ..Surprisingly, although these mice have elevated numbers of Tregs, a high proportion of those cells are CD25- and CD62Llo, and the animals develop a severe polyclonal lymphoproliferative disorder...
  25. Pathophysiology of Adult T-cell Leukemia/Lymphoma
    UTPAL P DAVE; Fiscal Year: 2013
    ..infection, viral proteins expressed by HTLV-1, notably tax, transcriptionally activate expression of IL2 and IL2R genes resulting in lymphoproliferation by autocrine signaling...
  26. Characterization of a novel T cell activating protein in arthritis
    Raphael Hirsch; Fiscal Year: 2013
    ..Furthermore, FSTL-1 prolongs expression of the T cell activation molecule, CD25. To characterize the T cell activating properties of FSTL-1, we will determine the T cell activation phenotype ..
  27. Perfluorooctane Sulfonate (PFOS) affects 1gM Production via IL-2
    Margie M Peden Adams; Fiscal Year: 2010
    ..suppresses antibody production via altered T-cell IL-2 production but not macrophage cytokine production or altered CD25, CD27, or CD70 expression. Aim 1...
  28. S. aureus and Regulatory T cells in the Failure of Oral Tolerance
    Anne Marie Singh; Fiscal Year: 2013
    ..aureus plays a crucial role in the cutaneous inflammation of atopic eczema and activation of CD25+ Treg cells with S. aureus enterotoxin B (SEB) abrogated their suppressive phenotype...
  29. Immunization against Atherosclerosis
    Guoxing Zheng; Fiscal Year: 2012
    ..Importantly, CD4+CD25+Foxp3+ regulatory T cells (Treg), a subset of T cells that function to suppress the response of Teff, have been ..
  30. Transfusion-associated immune hemolysis
    Karina Yazdanbakhsh; Fiscal Year: 2010
    ..Increasing evidence indicates that CD4+ regulatory T cells (Tregs) characterized by co- expression of CD25 and the forkhead/winged helix transcription factor(Foxp3) are key suppressors of immunopathological immune ..
  31. Selective MicoRNA modification to enhance regulatory T cell function in IBD
    Colm Collins; Fiscal Year: 2013
    ..e. TNF[unreadable]ARE) that recapitulates many features of Crohn's disease;demonstrated expansion of CD4+CD25+Foxp3+ regulatory T cells (Tregs) in the inflamed ileum along the disease timecourse by both flow cytometry and RT-..
  32. Purification &Characterization of Adenosine Receptors
    Joel M Linden; Fiscal Year: 2009
    ..Possible targets of AaA agonists are CD4+ T effector cells (CD25-) NKT cells, antigen presenting cells (including macrophages and dendritic cells) and T regulatory cells (CD25+)...
  33. Estrogen and Immunoprotection in Experimental Stroke
    Patricia D Hurn; Fiscal Year: 2013
    ..to abnormal activation of splenic immunocytes, particularly T lymphocytes that have a regulatory phenotype (CD4+CD25+FoxP3+ Treg cells) and ordinarily provide endogenous immunosuppression...
  34. T regulatory cell suppression of CD8+ cell responses during FIV Infection
    JONATHAN FOGLE; Fiscal Year: 2012
    ..dysfunction is the result of "clonal anergy" induced by membrane-bound TGF-beta (mTGF-beta) on virus activated CD4+CD25+ T reg cells that engage TGF-betaRII on the target cell...
  35. Immunoregulation and immunotherapy of breast cancer
    Robert H Vonderheide; Fiscal Year: 2012
    ..a novel vaccine against the human telomerase reverse transcriptase (hTERT) and survivin in combination with anti-CD25 antibody daclizumab in patients with hormone receptor positive (HR+) metastatic disease...
  36. Role of Regulatory T Cells in Chronic Obstructive Pulmonary Disease
    Wissam M Chatila; Fiscal Year: 2012
    ..nonsmokers), by isolating CD4+CD25hi cells from the peripheral blood of subjects and performing conventional CD4+CD25- and CD8+ proliferative and cytokine production assays;3) to determine the effect of smoking on Treg cell function ..
  37. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..Project 2: CD25+CD4+ T cells and IgE-mediated disease in humans: The phenotype and function of a novel CD25+CD4+ subset associated ..
  38. CD4 aptamer-siRNA chimeras to prevent HIV transmission
    Judy Lieberman; Fiscal Year: 2013
    ..Preliminary data obtained after intravaginal application of CD4 aptamer-siRNA chimeras in NOD/scid/IL2R?-/- mice reconstituted with human bone marrow, fetal liver and thymus (BLT mice) show both uptake of Cy3-labeled ..
  39. T Regulatory Cells in HIV Infection
    Douglas F Nixon; Fiscal Year: 2010
    The overall aim of this study is to determine the phenotype, function, and role of CD4+CD25+ regulatory T cells (Treg cells) in HIV infected and uninfected humans...
  40. KLF10, T regulatory cells, and atherogenesis
    Mark W Feinberg; Fiscal Year: 2012
    ..Recent studies have shown a critical role for CD4+CD25+ T regulatory cells for inhibiting the progression of atherosclerosis, an effect dependent in part on TGF-2 ..
  41. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2013
    ..Understanding the factors that reverse autoimmunity in the IL-2Rb- deficient model may also provide new information concerning the etiology and potential therapy that may be generally common to several human autoimmune diseases. ..
  42. A Novel Therapy for Restricted Induction of Tolerance to Treat Diabetes Mellitus
    Kanneganti Murthy; Fiscal Year: 2013
    ..may result from excess pathogenic Th1/Th17 cells and deficient tolerance-inducing antigen (Ag)-specific Treg (FOXp3+CD25+) and Tr1 CD4+ cells (FOXp3-CD25- IL-10high)...
  43. H. Pylori infection and manipulation of the host inflammatory response
    VICTORIA ELIZABETH RUIZ; Fiscal Year: 2010
    ..pylori infection. The second aim is to elucidate the role of CD4+CD25+Foxp3+ regulatory T-lymphocytes during chronic H...
  44. Blood Stem Cell Transplantation as Immunotherapy
    Samuel Strober; Fiscal Year: 2013
    ..S. Negrin, Leader) will perform additional preclinical studies that elucidate the function of donor CD4+CD25+ Treg cells and show how they can be used more effectively to prevent GVHD while maintaining graft anti-tumor (GVT) ..
  45. Role of Dendritic Cells in H pylori-induced Treg-mediated Host Immune Tolerance
    John Y Kao; Fiscal Year: 2013
    ..pylori-stimulated BMDCs into mice to induce H. pylori- specific Tregs and then use CD25 neutralizing antibodies to study the effect of Treg depletion on H. pylori tolerance...
  46. An Immune Tolerance Strategy for Prevention and Treatment of Atherosclerosis
    JAYME contact BORENSZTAJN; Fiscal Year: 2011
    ..indicates that tolerance induced by antigen-coupled cells is due, at least in part, to the up-regulation of CD4+CD25+FoxP3+ regulatory T cells (Tregs) that function in the suppression of pathogenic T cells...
  47. Immunology of Factor IX Gene Transfer to Liver
    Roland W Herzog; Fiscal Year: 2013
    ..IX transgene product. Tolerance induction critically depended on a CD4+CD25+FoxP3+ regulatory T cell (Treg) response...
  48. Regulation of Foxp3 Function
    Andrew D Wells; Fiscal Year: 2012
    ..Expression of Foxp3 initiates a unique transcriptional program which includes the induction of genes such as GITR, CD25, CTLA-4, IL-10 and TGF2, and repression of pro-inflammatory cytokine genes such as IL-2 and IFN?...
  49. T CELL RESPONSE TO MYELIN PROTEOLIPID PROTEIN
    Vijay K Kuchroo; Fiscal Year: 2013
    ..the Fox-P3 transcription factor, we have generated a Foxp3- EGFP "knock-in" mouse strain in order to track CD4+ CD25+ Fox-P3+ Tregs by GFP-expression...
  50. Innate Regulation and CD4+Th1/17 Immunity in TMEV-Induced Demyelination
    Stephen D Miller; Fiscal Year: 2013
    ..Employing depletion, supplementation and genetic approaches, Aim 1 will test the hypothesis that activation of CD4+CD25+Foxp3+ Tregs plays a major role in regulating susceptibility to TMEV-IDD by inhibiting development of virus-..
  51. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    DAVID WILLIAM SCOTT; Fiscal Year: 2013
    ..Importantly, we found that CD25+, FoxP3+ regulatory T cells were required for both the induction and maintenance of tolerance in this system...
  52. Lung Transplantation and Immune Tolerance in Young Recipients
    Richard Nash; Fiscal Year: 2007
    ..been further characterized and the findings are consistent with a peripheral mechanism involving regulatory (CD4+ CD25+) T cells...
  53. Novel Strategies for Cancer Immunotherapy in Stem Cell Transplant
    Yiping Yang; Fiscal Year: 2013
    ..production of immune inhibitory cytokines, and induction of tumor-specific T cell tolerance mediated by CD4+CD25+ regulatory T (TReg) cells...
  54. Treg Migration in GVHD
    Jonathan Serody; Fiscal Year: 2009
    ..The expansion of alloreactive T cells is controlled both by homeostatic proliferation and regulatory T cells. CD4+/CD25+ Treg cells have been shown to be capable of inhibiting GVHD in multiple different murine models and the expansion ..
  55. Integrin CD11b and its role in immune suppression
    Li Zhang; Fiscal Year: 2010
    ..including CD11b+CD11c- macrophages and CD11c+ dendritic cells (DC), and also on the formation of a distinct CD4+CD25+ T regulatory (Treg) cell population that expresses the transcription factor Foxp3...
  56. T Cell Homeostasis in Systemic Autoimmunity
    Argyrios N Theofilopoulos; Fiscal Year: 2012
    ..receptor downregulation and their implications to autoimmunity by determining the dynamic regulation of CD127 and CD25, the downregulation of CD127 on chronically-activated transgenic CD4 T cells by the regulated expression of a ..
  57. APOPTOSIS OF SMOOTH MUSCLE CELLS IN CAROTID PLAQUES
    Devendra K Agrawal; Fiscal Year: 2013
    ..Also, stronger immunoreactivity of Foxp3, IL-10 and CD25 with preponderance of CD4? T cells in carotid plaques of asymptomatic than symptomatic patients...
  58. BDNF-engineered stem cell mediated neuroprotection in EAE
    SUHAYL S DHIB JALBUT; Fiscal Year: 2010
    ..pathogenic T cells by suppressing production of proinflammatory cytokines and/or promoting differentiation of CD4+CD25+ regulatory T cells (Tregs)...
  59. Role of Novel T Cell Costimulatory Pathways in Allograft Rejection and Tolerance
    Mohamed H Sayegh; Fiscal Year: 2011
    ..preliminary data, that the TIM-1 :TIM-4 pathway may have an important role in the generation and/or function of CD4+CD25+ regulatory T cells in vivo...
  60. Immune mechanisms of CAM intervention in autoimmunity
    BRIAN CALVIN ASTRY; Fiscal Year: 2013
    ..reduction of IL- 17 response is owing to an altered balance between CD4+ T helper 17 (Th17) and CD4+CD25+Foxp3+ T regulatory cells (Treg), which is influenced in part by altered processing and presentation of the disease-..
  61. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen D Miller; Fiscal Year: 2013
    ..antigen representation (cross-tolerance) and induction of both clonal anergy and activation of antigen-specific CD4+CD25+ iTregs which together regulate both na[unreadable]ve and activated encephalitogenic Th1/17 cells...
  62. The Effect of Bromelain on CD4+ T Cell Function in Asthma
    ERIC RICHARD SECOR; Fiscal Year: 2012
    ..We have observed that Br treatment reduces CD25, a key activation marker on CD4+ T cells as well as alters MHC-II and CD86 levels on antigen presenting cells (APCs)..
  63. Immunological Monitoring of Heart Allograft Recipients
    Nicole Suciu Foca; Fiscal Year: 2006
    ..Daclizumab, a humanized anti-CD25 antibody has been added to conventional immunosuppression to block and delete alloreactive T cells which express ..
  64. Consequences of Aging on Immune Response and Transplant Outcome
    STEFAN GUNTHER TULLIUS; Fiscal Year: 2013
    ..At the same time, we observed a well preserved suppressor function of old alloantigen-specific CD4+CD25+FoxP3+ T cells...
  65. IL-2-dependent mechanisms in T1D
    Thomas R Malek; Fiscal Year: 2013
    ..However, other than induction of Foxp3 and CD25, little is known concerning the mechanisms activated in Tregs by weak IL-2R signaling...
  66. Modulation of HIV-1 Replication and T Cell Activation by FoxP3
    Lishan Su; Fiscal Year: 2007
    Overt immune activation is associated with AIDS. Given their proven activity in suppressing immune responses, CD4+CD25+FoxP3+ Treg cells may play an important role in HIV-1 diseases progression; With the CD4 receptor and CCR5/CXCR4 ..
  67. Monoclonal Antibodies Against T-Regulatory Cells
    Alan Epstein; Fiscal Year: 2005
    ..of a tumor targeting monoclonal antibody (TNT) and the human chemokine LEC (Liver-expressed chemokine, CCL16) and CD25+ T-regulatory cell depletion can produce complete and lasting cures of two solid tumor models of the BALB/c mouse...