CD21

Summary

Gene Symbol: CD21
Description: complement component (3d/Epstein Barr virus) receptor 2
Alias: C3DR, CD21, CVID7, SLEB9, EBV receptor, complement C3d receptor, complement receptor type 2
Species: human

Top Publications

  1. ncbi Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21)
    Michelle Balbo
    INSERM U 672 ex U 354, Immunochimie des Régulations Cellulaires et des Interactions Virales, Bâtiment G8, Campus 1, Génopole d Evry, 5 rue Henri Desbrueres, 91030, Evry Cedex, France
    FEMS Microbiol Lett 249:359-66. 2005
  2. ncbi The role of complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) in promoting C3 fragment deposition and membrane attack complex formation on normal peripheral human B cells
    Claus Henrik Nielsen
    Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
    Eur J Immunol 32:1359-67. 2002
  3. pmc Transcriptional effects of a lupus-associated polymorphism in the 5' untranslated region (UTR) of human complement receptor 2 (CR2/CD21)
    Mark N Cruickshank
    Biochemistry and Molecular Biology, School of Chemistry and Biochemistry, The University of Western Australia, Perth, Western Australia, Australia
    Mol Immunol 52:165-73. 2012
  4. pmc Alterations of the B-cell response by HIV-1 replication
    Xiaoying Shen
    Department of Surgery, Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Curr HIV/AIDS Rep 8:23-30. 2011
  5. doi Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease
    Ikuko Mizuta
    Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, 2 2 B9 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Hum Genet 124:89-94. 2008
  6. ncbi Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor
    A Fujisaku
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City
    J Biol Chem 264:2118-25. 1989
  7. pmc Follicular dendritic cells specifically express the long CR2/CD21 isoform
    Y J Liu
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Exp Med 185:165-70. 1997
  8. ncbi Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein
    S A Boackle
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Immunity 15:775-85. 2001
  9. pmc Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus
    Hui Wu
    Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:3961-6. 2007
  10. ncbi The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules
    L E Bradbury
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115 6084
    J Immunol 149:2841-50. 1992

Research Grants

Detail Information

Publications208 found, 100 shown here

  1. ncbi Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21)
    Michelle Balbo
    INSERM U 672 ex U 354, Immunochimie des Régulations Cellulaires et des Interactions Virales, Bâtiment G8, Campus 1, Génopole d Evry, 5 rue Henri Desbrueres, 91030, Evry Cedex, France
    FEMS Microbiol Lett 249:359-66. 2005
    ..These infected B cells expressed a p45 kDa protein which interacted with the intracellular domain of CD21, the EBV/C3d receptor...
  2. ncbi The role of complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) in promoting C3 fragment deposition and membrane attack complex formation on normal peripheral human B cells
    Claus Henrik Nielsen
    Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
    Eur J Immunol 32:1359-67. 2002
    ..The process is mediated via complement receptor type 2 (CR2, CD21), with complement receptor type 1 (CR1, CD35) playing a subsidiary role...
  3. pmc Transcriptional effects of a lupus-associated polymorphism in the 5' untranslated region (UTR) of human complement receptor 2 (CR2/CD21)
    Mark N Cruickshank
    Biochemistry and Molecular Biology, School of Chemistry and Biochemistry, The University of Western Australia, Perth, Western Australia, Australia
    Mol Immunol 52:165-73. 2012
    ..These data confirm the effects of rs3813946 on CR2 transcription, identifying the 5' UTR to be a novel regulatory element for the CR2 gene in which variation may alter gene function and modify the development of lupus...
  4. pmc Alterations of the B-cell response by HIV-1 replication
    Xiaoying Shen
    Department of Surgery, Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Curr HIV/AIDS Rep 8:23-30. 2011
    ..B-cell dysfunction in vivo is unknown, although roles for HIV proteins (Env, Tat, and Nef) and virions binding to CD21 on B cells have been identified...
  5. doi Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease
    Ikuko Mizuta
    Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, 2 2 B9 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Hum Genet 124:89-94. 2008
    ..Our genetic analysis suggests that CALB1 is associated with PD independently of SNCA, and that FGF20 is associated with PD synergistically with SNCA...
  6. ncbi Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor
    A Fujisaku
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City
    J Biol Chem 264:2118-25. 1989
    The human C3d/Epstein-Barr virus receptor (CR2/CD21) is a 145-kDa protein primarily expressed on mature B lymphocytes. CR2 is a member of the regulators of complement activation (RCA) gene family found on band q32 of chromosome 1...
  7. pmc Follicular dendritic cells specifically express the long CR2/CD21 isoform
    Y J Liu
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Exp Med 185:165-70. 1997
    ..By expression cloning, a cDNA clone encoding for the long human CR2/ CD21 isoform (CD21L) that contains an additional exon (10a) was isolated...
  8. ncbi Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein
    S A Boackle
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Immunity 15:775-85. 2001
    ..congenic interval corresponding to Sle1c contains Cr2, which encodes complement receptors 1 and 2 (CR1/CR2, CD35/CD21)...
  9. pmc Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus
    Hui Wu
    Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:3961-6. 2007
    ..Our findings reveal that CR2 is a likely susceptibility gene for human lupus at 1q32.2, extending previous studies suggesting that CR2 participates in the pathogenesis of systemic lupus erythematosus...
  10. ncbi The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules
    L E Bradbury
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115 6084
    J Immunol 149:2841-50. 1992
    ..with B cell lines solubilized by digitonin have shown CD19 to be part of a multimolecular complex that includes CD21 (CR2) and other unidentified proteins...
  11. ncbi Mechanism for complement-mediated, antibody-dependent enhancement of human immunodeficiency virus type 1 infection in MT2 cells is enhanced entry through CD4, CD21, and CXCR4 chemokine receptors
    W Edward Robinson
    Department of Pathology, University of California, Irvine, CA 92697 4800, USA
    Viral Immunol 19:434-47. 2006
    ..Finally, anti-HIV immunoglobulin enhanced replication of not only group M clade B HIV but also group M clade D and group O isolates. These data demonstrate that antibodies mediating C'ADE of HIV infection are broadly reactive...
  12. pmc Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes
    M D Moore
    Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 84:9194-8. 1987
    Complementary DNA clones for complement receptor type 2 (CR2), the B-lymphocyte membrane protein that serves as the receptor for Epstein-Barr virus and the C3d complement fragment, were obtained by screening a lambda gt11 library ..
  13. pmc Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins
    J J Weis
    Department of Rheumatology and Immunology, Brigham and Women s Hospital, Boston, Massachusetts
    J Exp Med 167:1047-66. 1988
    Human complement receptor type 2 (CR2) is the B lymphocyte receptor for C3d and the Epstein-Barr virus...
  14. ncbi CR2/CD21 proximal promoter activity is critically dependent on a cell type-specific repressor
    D Ulgiati
    Department of Immunology and Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 167:6912-9. 2001
    Transcription of the human complement receptor type 2 (CR2/CD21) gene is controlled by both proximal promoter and intronic elements. CR2 is primarily expressed on B cells from the immature through mature cell stages...
  15. pmc Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes
    A K Matsumoto
    Division of Molecular and Clinical Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Exp Med 178:1407-17. 1993
    The CD21/CD19/TAPA-1 complex of B lymphocytes amplifies signal transduction through membrane immunoglobulin (mIg), recruits phosphatidylinositol 3-kinase (PI3-kinase), and induces homotypic cellular aggregation...
  16. doi Comparative binding of soluble fragments (derCD23, sCD23, and exCD23) of recombinant human CD23 to CD21 (SCR 1-2) and native IgE, and their effect on IgE regulation
    Sandra Lyn Bowles
    Nelson Mandela Metropolitan University, Port Elizabeth, South Africa
    Cell Immunol 271:371-8. 2011
    ..responsible for type I hypersensitivities, is regulated by interactions between its receptor, CD23, and co-receptor CD21. To examine comparative binding of recombinant human CD21 SCR 1-2 and native human IgE to CD23 plus the effect of ..
  17. ncbi Variation in the Epstein-Barr virus receptor, CR2, and risk of multiple sclerosis
    Kc Simon
    Mult Scler 13:947-8. 2007
  18. ncbi B cells from mice prematurely expressing human complement receptor type 2 are unresponsive to T-dependent antigens
    Louise Birrell
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, UK
    J Immunol 174:6974-82. 2005
    b>Complement receptor type 2 (CR2/CD21), in association with CD19, plays an important role in enhancing mature B cell responses to opsonized Ags...
  19. ncbi Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study
    Hannah E Gilbert
    Department of Biochemistry and Molecular Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, UK
    J Mol Biol 346:859-73. 2005
    b>Complement receptor type 2 (CR2, CD21) forms a tight complex with C3d, a fragment of C3, the major complement component...
  20. pmc Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19
    A K Matsumoto
    Division of Molecular and Clinical Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Exp Med 173:55-64. 1991
    ....
  21. pmc T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE)
    E Levy
    Howard Hughes Medical Institute Laboratories, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
    Clin Exp Immunol 90:235-44. 1992
    Complement receptor 2 (CR2, CD21), the receptor for both the C3d,g portion of human complement component C3 and the Epstein-Barr virus, has been recently described on peripheral T cells...
  22. ncbi NF-kappaB regulates the expression of the human complement receptor 2 gene
    Mate Tolnay
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 169:6236-43. 2002
    ..Thus, at the onset of an infection, LPS could sensitize the B cell to Ag by enhancing the level of CR2-costimulatory molecules on the cell surface...
  23. pmc Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer
    Rungnapa Hirunsatit
    Genetics Unit, Department of Anatomy, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Thailand
    BMC Genet 4:3. 2003
    ..This research explores potential associations between nasopharyngeal epithelial EBV receptor and NPC susceptibility...
  24. ncbi Intrinsic B cell hypo-responsiveness in mice prematurely expressing human CR2/CD21 during B cell development
    Liudmila Kulik
    Department of Medicine and Immunology, UCHSC, Denver, CO 80262, USA
    Eur J Immunol 37:623-33. 2007
    ..Overall, these data suggest that premature hCR2 expression and the consequences thereof during B cell development intrinsically alters the way mature B cells develop and subsequently respond to antigen through the BCR signaling complex...
  25. pmc Epstein Barr virus/complement C3d receptor is an interferon alpha receptor
    A X Delcayre
    California Institute for Biological Research, La Jolla 92037
    EMBO J 10:919-26. 1991
    Interferon alpha contains a sequence motif similar to the complement receptor type two (CR2/CD21) binding site on complement fragment C3d...
  26. ncbi Are respiratory allergic diseases related to atopic dermatitis?
    L Lugović
    Department of Dermatovenerology, Zagreb Clinical Hospital Center, Zagreb University School of Medicine, Zagreb, Croatia
    Coll Antropol 24:335-45. 2000
    ..The values of CD21 were decreased in 16 AD patients [6/10 in "pure" AD, and 10/20 in "mixed" AD]...
  27. doi Expression of complement receptor 2 (CD21), membrane IgM and the inhibitory receptor CD32 (FcgammaRIIb) in the lymphoid tissues of neonatal calves
    Kuldeep S Chattha
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Vet Immunol Immunopathol 137:99-108. 2010
    ..The activating receptor CD21 (CR2), when co-ligated with membrane IgM (mIgM) by complement-bound antigen lowers the threshold for activation of ..
  28. ncbi Immunophysical exploration of C3d-CR2(CCP1-2) interaction using molecular dynamics and electrostatics
    Li Zhang
    Department of Chemistry, University of California at Riverside, Riverside, CA 92521, USA
    J Mol Biol 369:567-83. 2007
    ....
  29. ncbi A minimum CR2 binding domain of C3d enhances immunity following vaccination
    Joseph F Bower
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15261, USA
    Adv Exp Med Biol 586:249-64. 2006
    ..C3d has been hypothesized to enhance immunity by direct interaction with complement receptor 2 (CR2/CD21) on immune cells...
  30. pmc Heterogeneous nuclear ribonucleoprotein D0B is a sequence-specific DNA-binding protein
    M Tolnay
    Department of Clinical Physiology, Walter Reed Army Institute of Research, 14th and Dahlia Streets, Bldg 40, Washington, DC 20307 5100, USA
    Biochem J 338:417-25. 1999
    ..Our results suggest a new physiological role for hnRNP D0B that involves binding to double- and single-stranded DNA sequences in a specific manner and functioning as a transcription factor...
  31. pmc Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair
    James M Kovacs
    Department of Medicine and Immunology, University of Colorado Denver, School of Medicine, Aurora, Colorado 80045, USA
    J Biol Chem 285:27251-8. 2010
    Human complement receptor type 2 (CR2 and CD21) is a cell membrane receptor, with 15 or 16 extracellular short consensus repeats (SCRs), that promotes B lymphocyte responses and bridges innate and acquired immunity...
  32. doi Novel function of complement C3d as an autologous helper T-cell target
    Paul M Knopf
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    Immunol Cell Biol 86:221-5. 2008
    ..C3d binds to the B-cell complement receptor 2 (CR2 or CD21); this binding serves as a co-activation signal to the B cell when the polysaccharide antigen portion binds ..
  33. pmc Identification of murine complement receptor type 2
    J D Fingeroth
    Division of Infectious Diseases, Dana Farber Cancer Institute, Boston, MA 02115
    Proc Natl Acad Sci U S A 86:242-6. 1989
    A rabbit antiserum reactive with the human complement component C3d/Epstein-Barr virus receptor (complement receptor type 2, CR2) immunoprecipitates a Mr 155,000 murine B-cell surface antigen...
  34. ncbi Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway
    Taras Lyubchenko
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    J Immunol 174:3264-72. 2005
    ..product of the C3 component of complement that can facilitate the coligation of the complement receptor 2 (CR2/CD21) with the BCR via C3dg/Ag complexes...
  35. ncbi A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation
    K W Makar
    Department of Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Int Immunol 13:657-64. 2001
    Expression of human complement receptor type 2 (CR2/CD21) is primarily restricted to mature B cells and follicular dendritic cells...
  36. pmc Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones
    Isabelle Isnardi
    Laboratory of Molecular Immunology, Hospital for Special Surgery, New York, NY, USA
    Blood 115:5026-36. 2010
    Complement receptor 2-negative (CR2/CD21(-)) B cells have been found enriched in patients with autoimmune diseases and in common variable immunodeficiency (CVID) patients who are prone to autoimmunity...
  37. pmc Laser-capture microdissection of oropharyngeal epithelium indicates restriction of Epstein-Barr virus receptor/CD21 mRNA to tonsil epithelial cells
    Ru Jiang
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA
    J Oral Pathol Med 37:626-33. 2008
    ..The virus uses CD21 for attachment to B cells which constitutively express the protein...
  38. ncbi Distribution of the chromatin protein DEK distinguishes active and inactive CD21/CR2 gene in pre- and mature B lymphocytes
    Hong Gang Hu
    Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    Int Immunol 17:789-96. 2005
    ..As the first study of its kind, we investigate the distribution of DEK at the CD21/complement receptor 2 gene regulatory regions in two B lymphocyte lines, namely Ramos, which expresses the CD21 ..
  39. pmc Herpes simplex virus glycoprotein C: molecular mimicry of complement regulatory proteins by a viral protein
    H P Huemer
    Institute for Hygiene, University of Innsbruck, Austria
    Immunology 79:639-47. 1993
    ..e. the complement system. In addition, the inhibition of the C3/CR2 interaction may suggest a possible immunoregulatory role of HSV glycoprotein C...
  40. ncbi Serum regulates the expression of complement receptor 2 on human B cell lines
    M Tolnay
    Department of Cellular Injury, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Immunopharmacol Immunotoxicol 22:205-19. 2000
    ..Because stimuli that alter CR2 expression can influence the extent of the B cell response to antigen-C3d complexes, serum factors may play a role in regulating the responsiveness of B cells...
  41. ncbi Expression of human complement receptor 2 (CR2, CD21) in Cr2-/- mice restores humoral immune function
    K J Marchbank
    Division of Rheumatology, Departments of Medicine and Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 165:2354-61. 2000
    b>Complement receptor type 2 (CR2, CD21) is expressed by both human and murine B cells and has been demonstrated to play a pivotal role in the humoral immune response...
  42. ncbi A critical role for complement C3d and the B cell coreceptor (CD19/CD21) complex in the initiation of inflammatory arthritis
    Christopher J Del Nagro
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center, The Burnham Institute, La Jolla, CA 92037, USA
    J Immunol 175:5379-89. 2005
    ..the C3d fragment to Ag promotes B lymphocyte activation through coengagment of the BCR and complement receptor 2 (CD21). Signal augmentation is thought to be achieved through enhanced recruitment and activation of CD21-associated CD19...
  43. ncbi Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice
    Olga Pozdnyakova
    Department of Pathology, Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:84-90. 2003
    ..in the humoral immune response to type III GBS capsular polysaccharide (III-PS), mice deficient in C3 or in CD21/CD35 (i.e., complement receptors 1 and 2; CR1/CR2) were immunized with III-PS...
  44. ncbi T cell-independent and T cell-dependent immunoglobulin G responses to polyomavirus infection are impaired in complement receptor 2-deficient mice
    Eva Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Virology 352:52-60. 2006
    ..Thus, our studies revealed a profound dependence of TI and TD antiviral antibody responses on CR2-mediated signals in PyV-infected mice, where the viral antigen is abundant and persistent...
  45. ncbi Expression of complement receptor 2 (CR2) on HTLV-1-infected lymphocytes and transformed cell lines
    T A McNearney
    , , Innsbruck, Austria
    Eur J Immunol 23:1266-70. 1993
    ..The expression of CR2 in cellular activation of T cells may be stage restricted. This study also expands the cellular distribution for CR2...
  46. pmc Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3
    Jason Twohig
    Department of Medical Biochemistry and Immunology, Cardiff University, Heath Park, Cardiff CF14 4XX, UK
    Mol Immunol 44:3434-44. 2007
    ....
  47. pmc A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury
    Yuxiang Huang
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Immunol 181:8068-76. 2008
    ..The data further indicate alternative pathway dependence for local and remote injury following intestinal ischemia/reperfusion in a clinically relevant therapeutic paradigm...
  48. ncbi Epstein-Barr virus and CD21 expression in gastrointestinal tumors
    Y S Kim
    Department of Pathology, College of Medicine, Korea University, Gojan Dong, Ansan, Korea
    Pathol Res Pract 194:705-11. 1998
    ..To determine the presence of CD21, an EBV receptor, in the EBV-associated gastrointestinal tumors, we, first, examined the EBV genome in sixty seven patients with ..
  49. ncbi A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice
    Hongbin Song
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Immunol 179:7860-7. 2007
    ..Of interest, a previous study reported that Crry-Ig, an untargeted counterpart of CR2-Crry, had minimal effect on disease, even when administered at a sufficiently high dose to maintain chronic complement inhibition...
  50. ncbi Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 159:3278-87. 1997
    ..are regulated in part by the CD19 cell surface receptor complex, which is composed of at least four proteins; CD19, CD21 (CR2, complement receptor 2), CD81, and Leu 13...
  51. doi A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration
    Barbel Rohrer
    Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA
    Adv Exp Med Biol 703:137-49. 2010
    ..In both the in vivo and in vitro paradigm of RPE damage, a model requiring molecular events known to be involved in AMD, complement-dependent VEGF production, was confirmed. These data may open new avenues for AMD treatment strategies...
  52. doi Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period
    Armita Bahrami
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 34:1504-13. 2010
    ..Melan A, HMB-45, CD34, TLE1, CD31, HHV8, smooth muscle actin, desmin, ALK1, CD99, Myo-D1, myogenin, c-kit, INI1, CD21, p63, calretinin, WT1, and TTF1...
  53. ncbi Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases
    S A Pileri
    Service of Pathologic Anatomy and Hematopathology, Institute of Haematology and Clinical Oncology L e A Seràgnoli, Bologna University, Italy
    Histopathology 41:1-29. 2002
    ..those reactive with histiocytes (CD68, lysozyme (LYS)), Langerhans cells (CD1a), follicular dendritic cells (FDC: CD21, CD35) and S100 protein...
  54. ncbi Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia
    Kenji M Cunnion
    Department of Pediatrics and Duke Clinical Research Institue, Duke University Medical Center, Durham, NC, USA
    J Lab Clin Med 143:358-65. 2004
    ..Complement receptor 1 (CD35) is the primary receptor for the opsonin C3b. Mice deficient in CD35/CD21 showed a 67% decrease in survival compared with normal mice, suggesting that CD35/CD21 is of major importance in ..
  55. ncbi Transmission of antibody-induced arthritis is independent of complement component 4 (C4) and the complement receptors 1 and 2 (CD21/35)
    Samuel Solomon
    Immunology, Department of Biology, Faculty of Sciences, University of Konstanz, Konstanz, Germany
    Eur J Immunol 32:644-51. 2002
    ..The crucial role of complement C5, while neither classical nor lectin pathway is necessary, indicates that the alternative complement pathway may have a role in the K/BxN serum-induced RA model...
  56. ncbi Changes in antigen expression on B lymphocytes during HIV infection
    L Ginaldi
    Department of Internal Medicine and Public Health, University of L Aquila, Italy
    Pathobiology 66:17-23. 1998
    ..the level of expression of a series of constitutive surface markers in B lymphocytes (HLA-DR, CD19, CD20, CD21, CD22) from 30 HIV-seropositive adult patients and 20 normal controls...
  57. pmc Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice
    Irina Petrushina
    The Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4540, USA
    J Neuroinflammation 5:42. 2008
    ..mannan that can promote a Th2-polarized immune response through interactions with mannose-binding and CD35/CD21 receptors of the innate immune system...
  58. ncbi The partly folded back solution structure arrangement of the 30 SCR domains in human complement receptor type 1 (CR1) permits access to its C3b and C4b ligands
    Patricia B Furtado
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    J Mol Biol 375:102-18. 2008
    ..The extra-cellular component of CR1 is comprised of 30 short complement regulator (SCR) domains, whereas complement receptor type 2 (CR2) has 15 SCR domains and factor H (FH) has 20 SCR domains...
  59. ncbi Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice
    K Takahashi
    Department of Pathology, University of Iowa School of Medicine, Iowa City 52242, USA
    J Immunol 159:1557-69. 1997
    Human complement receptors type 1 (hCR1;CD35) and type 2 (hCR2;CD21) are expressed on B lymphocytes at specific stages during differentiation and activation...
  60. ncbi Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice
    E M Garabedian
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:23729-40. 1997
    ....
  61. pmc Sequence comparisons of plasmids pBJS-O of Spiroplasma citri and pSKU146 of S. kunkelii: implications for plasmid evolution
    Bharat D Joshi
    Department of Biochemistry and Molecular Biology, Oklahoma State University, 246 NRC, Stillwater, OK 74078, USA
    BMC Genomics 6:175. 2005
    ..The S. kunkelii CR2-3X plasmid, pSKU146, encodes a homolog of SARP1, Sk-ARP1. Due to the close phylogenetic relationship of the two pathogens, we hypothesized that the two plasmids are closely related as well...
  62. doi 18F-FDG uptake in reactive neck lymph nodes of oral cancer: relationship to lymphoid follicles
    Tassei Nakagawa
    Department of Radiology, Asahi General Hospital, Chiba, Japan
    J Nucl Med 49:1053-9. 2008
    ..Reactive lymphadenopathy is well known as a principal cause of false-positive findings on PET/CT for nodal staging. We investigated the reactive lymph nodes of oral cancer to elucidate the (18)F-FDG-avid area in these nodes...
  63. ncbi Epstein-Barr virus (EBV) infection in B-cell non-Hodgkin's lymphomas in children: virus latency and its correlation with CD21 and CD23 molecules
    Aldona Kasprzak
    Department of Histology and Embryology, University of Medical Sciences, Poznan, Poland
    Folia Histochem Cytobiol 45:169-79. 2007
    ..Other studies demonstrated that only those B lymphocytes which carry the surface CD21 (EBV receptor) become transformation-competent...
  64. ncbi Complement receptors and the shaping of the natural antibody repertoire
    V Michael Holers
    Division of Rheumatology, Department of Medicine, B 115, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Springer Semin Immunopathol 26:405-23. 2005
    ..have clearly demonstrated a key role for the complement C3d activation fragment receptor designated CR2 (complement receptor type 2) in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign ..
  65. ncbi Mucosal type mast cells express complement receptor type 2 (CD21)
    Márton Andrásfalvy
    Department of Immunology, Eotvos Lorand University, Budapest, Hungary
    Immunol Lett 82:29-34. 2002
    ..Complement receptor type 1 (CR1/CD35) and type 2 (CR2/CD21) interacting with the larger activation products, such as C3b and C3d, have so far been shown on serosal type mast ..
  66. doi Fusion of Ross chicken complement component C3d-P29 repeats with a chicken viral Newcastle disease virus F gene enhances immune responses following DNA immunization
    Dong Liu
    College of Animal Science and Veterinary Medicine, Shandong Agriculture University, Daizong Road No 61, Tai an, Shandong, China
    Viral Immunol 22:221-31. 2009
    C3d, a split product of C3, interacts with its receptor (CR2 or CD21) on B cells and follicular dendritic cells (FDCs) and is crucial for induction and maintenance of a normal humoral immune response...
  67. pmc Long term outcome of ocular adnexal lymphoma subtyped according to the REAL classification. Revised European and American Lymphoma
    C Auw-Haedrich
    University Eye Hospital, Freiburg, Germany
    Br J Ophthalmol 85:63-9. 2001
    ..To classify ocular adnexal lymphomas according to the Revised European and American Lymphoma (REAL) classification and to determine any correlation between clinical features or histomorphological variables with the patients' outcome...
  68. ncbi Distinct sequences in the cytoplasmic domain of complement receptor 2 are involved in antigen internalization and presentation
    Denise V Barrault
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    J Immunol 172:3509-17. 2004
    ..The finding that distinct sequences in the cytoplasmic domain of mCR2 are essential for BCR-independent Ag presentation leads us to propose a novel role for CR2...
  69. pmc The basolateral amygdala determines the effects of fear memory on sleep in an animal model of PTSD
    Laurie L Wellman
    Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, P O Box 1980, Norfolk, VA, 23507, USA
    Exp Brain Res 232:1555-65. 2014
    ..These data indicate that BLA is an important regulator of stress-induced alterations in sleep and an important site for forming fear memories that can alter sleep...
  70. doi Comparison of umbilical cord blood allogeneic stem cell transplantation vs. auto-SCT for adult acute myeloid leukemia patients in second complete remission at transplant: a retrospective study on behalf of the SFGM-TC
    Patrice Chevallier
    Centre Hospitalier et Universitaire CHU de Nantes, Hématologie Clinique, Centre d Investigation Clinique en Cancérologie CI2C, Université de Nantes and INSERM CRNCA UMR 892, Nantes, France
    Eur J Haematol 94:449-55. 2015
    ..However, this disease control advantage is counterbalanced by higher toxicity, highlighting the need for novel approaches aiming to decrease NRM after UCB allo-SCT. ..
  71. pmc A chimeric EBV gp350/220-based VLP replicates the virion B-cell attachment mechanism and elicits long-lasting neutralizing antibodies in mice
    Javier Gordon Ogembo
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB Room 323, Worcester, MA, 01605, USA
    J Transl Med 13:50. 2015
    ..Interaction between gp350/220 and complement receptor type 2 (CR2)/CD21 and/or (CR1)/CD35 on B-cells is required for infection...
  72. ncbi Signaling through CD70 regulates B cell activation and IgG production
    Ramon Arens
    Department of Hematology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Immunol 173:3901-8. 2004
    ..process, the cell surface receptors CD25, CD44, CD69, CD95, and GL7 were up-regulated, whereas the expression of CD21, CD62L, surface IgM (sIgM), and sIgD was decreased...
  73. ncbi In vitro and in vivo regulation by macrophage migration inhibitory factor (MIF) of expression of MHC-II, costimulatory, adhesion, receptor, and cytokine molecules
    Abram B Stavitsky
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44120, USA
    Cell Immunol 217:95-104. 2002
    ..Footpad injection of Mab to MIF reduced expression of B7-2 and CR1/CR2 by B cells and B7-2 by macrophages in these nodes. These data support our hypothesis...
  74. doi Flow cytometric immunophenotyping of feline bone marrow cells and haematopoietic progenitor cells using anti-human antibodies
    Atefeh Araghi
    1Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
    J Feline Med Surg 16:265-74. 2014
    ..A panel of six anti-feline mAbs (anti-CD21-like, anti-T lymphocytes, anti-CD172a, anti-granulocyte, anti-CD45-like and anti-CD18) and eight anti-human ..
  75. doi Chemical bonding in a linear chromium metal string complex
    Lai Chin Wu
    Center for Materials Crystallography, Department of Chemistry and iNANO, Aarhus University, Langelandsgade 140, Aarhus DK 8000, Denmark
    Inorg Chem 53:12489-98. 2014
    ..Delocalization indices and source function and natural bond orbital analyses are all indicative of localized Cr-Cr bonding interactions. ..
  76. doi Immunophenotypic evaluation of working Labrador Retrievers and German Shepherd dogs living in the same environment
    Alejandra Villaescusa
    Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Complutense University of Madrid, Avenida Puerta de Hierro s n, 28040 Madrid, Spain
    Vet J 193:602-5. 2012
    ..GS showed the highest relative percentage of CD3-/CD21- lymphocytes, whereas LR had the highest percentages of MHC II+ lymphocytes...
  77. ncbi Spin exchange effects on the physicochemical properties of tetraoxolene-bridged bimetallic complexes
    Dong Guo
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Inorg Chem 46:3257-74. 2007
    ....
  78. pmc An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation
    Svetlana N Tchepeleva
    Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Immunol 185:2331-9. 2010
    ..Cr2, which encodes complement receptors 1 and 2 (CR1/CR2; CD35/CD21), is a strong candidate gene for lupus susceptibility within this interval based on structural and functional ..
  79. pmc Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors
    M Birkenbach
    Department of Medicine, Harvard University, Boston, Massachusetts 02115
    J Virol 67:2209-20. 1993
    ..Two of these, the genes for CD21 and vimentin, were previously known to be induced by EBV infection...
  80. doi Restricted expression of EBV encoded proteins in in vitro infected CLL cells
    Eva Klein
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Nobelsv 16, Stockholm, Sweden
    Semin Cancer Biol 20:410-5. 2010
    ..CLL cells separated from blood express CR2, the complement receptor that serves also as EBV receptor. Thus CLL cells can be infected in vitro with the virus, however, in contrast to normal B lymphocytes, only ..
  81. doi Expression and role of CR1 and CR2 on B and T lymphocytes under physiological and autoimmune conditions
    Anna Erdei
    Department of Immunology, Biological Institute, Eotvos Lorand University, Budapest, Hungary
    Mol Immunol 46:2767-73. 2009
    ..This review focuses on the role of complement receptors CR1 (CD35) and CR2 (CD21) expressed on T and B cells...
  82. doi B-cell activation in cats with feline infectious peritonitis (FIP) by FIP-virus-induced B-cell differentiation/survival factors
    Tomomi Takano
    Laboratory of Veterinary Infectious Disease, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    Arch Virol 154:27-35. 2009
    ..The present study shows that: (1) the ratio of peripheral blood sIg(+) CD21(-) B-cells was higher in cats with FIP than in SPF cats, (2) the albumin-to-globulin ratio has negative correlation ..
  83. ncbi Follicular dendritic cell tumor of the liver associated with Epstein-Barr virus
    Li Yuan Bai
    Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
    Jpn J Clin Oncol 36:249-53. 2006
    ..These tumor cells were immunoreactive to CD21 and CD68. The test for Epstein-Barr virus (EBV)-encoded nuclear RNAs using in situ hybridization was also positive...
  84. doi Cord blood transplantation from unrelated donors for children with acute lymphoblastic leukemia in Japan: the impact of methotrexate on clinical outcomes
    Koji Kato
    Division of Hematology Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, Nakamura ku, Nagoya, Japan
    Biol Blood Marrow Transplant 17:1814-21. 2011
    ....
  85. ncbi Low doses of antigen coupled to anti-CR2 mAbs induce rapid and enduring IgG immune responses in mice and in cynomolgus monkeys
    Emily C Whipple
    Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, VA 22908, United States
    Mol Immunol 44:377-88. 2007
    ..Taken together, these results demonstrate the efficacy of using anti-CR2 mAbs as antigen carriers for i.v. immunization with small amounts of antigens without adjuvant...
  86. doi Mice expressing human CR1/CD35 have an enhanced humoral immune response to T-dependent antigens but fail to correct the effect of premature human CR2 expression
    Isabel Y Pappworth
    Applied Immunobiology and Transplantation, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
    Immunobiology 217:147-57. 2012
    We have previously demonstrated that mice expressing human complement receptor type 2 (CR2/CD21) during the CD43(+)/CD25(-) late pro-B cell stage of B cell development have marked changes in their subsequent B cell ontogeny...
  87. doi Canine CD8 T cells showing NK cytotoxic activity express mRNAs for NK cell-associated surface molecules
    Yi Chun Lin
    Animal Cancer Center, School of Veterinary Medicine, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan, ROC
    Vet Immunol Immunopathol 133:144-53. 2010
    ..CD8(+) cells derived from PBLs and lymphokine (IL-2)-activated killers (LAKs) of PBLs that was CD3(+), CD4(-), CD21(-), CD5(lo), alpha/betaTCR(+), and gamma/deltaTCR(-) contained substantially higher levels of mRNAs for NK cell-..
  88. ncbi Influence of high salinities on the degradation of diesel fuel by bacterial consortia
    Volker Riis
    UFZ Centre for Environmental Research Leipzig Halle, Department of Environmental Microbiology, Germany
    Can J Microbiol 49:713-21. 2003
    ..In light of our investigations, the bioremediation of contaminated saline soils should be quite possible if the salinity of the soil water is lower than 15% or if it is reduced below this limit by the addition of water...
  89. ncbi Interaction of iC3b with recombinant isotypic and chimeric forms of CR2
    K R Kalli
    Graduate Program in Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 147:590-4. 1991
    ....
  90. ncbi Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody
    T F Tedder
    J Immunol 133:678-83. 1984
    ..C3d receptors (C3dR) were identified by indirect immunofluorescence using the HB-5 monoclonal antibody, which recognizes a 145,000 m.w...
  91. ncbi Inhibition of macrophage inflammatory protein-1 alpha production by Epstein-Barr virus
    Wolfram J Jabs
    First Department of Medicine, Division of Nephrology, University of Lübeck School of Medicine, Lubeck, Germany
    Blood 99:1512-6. 2002
    ..a monoclonal antibody against EBV's major envelope glycoprotein, which mediates binding of the virus to the EBV receptor, CD21...
  92. pmc In vitro analysis of the E1A-homologous sequences of RIZ
    I M Buyse
    La Jolla Cancer Research Center, Burnham Institute, California 92037, USA
    J Virol 71:6200-3. 1997
    ..Despite this proximity, CE1 and CR2 appear to act independently. The data show similarities as well as differences between the homologous sequences of RIZ and E1A and contribute to an understanding of the biochemistry of these proteins...
  93. ncbi Immune cell differentiation in mammary gland tissues and milk of cows chronically infected with Staphylococcus aureus
    G Leitner
    National Mastitis Reference Center, Kimron Veterinary Institute, Ministry of Agriculture and Rural Development, Bet Dagan, Israel
    J Vet Med B Infect Dis Vet Public Health 50:45-52. 2003
    ..The number of B-lymphocytes bearing CD21+ was similar to that of CD8+ and were localized in the connective tissue as clusters of 2-5 cells, mainly in areas ..
  94. ncbi The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3
    M C Poznansky
    Molecular Immunopathology Unit, Medical Research Council Centre, Cambridge, UK
    J Immunol 143:1254-8. 1989
    ..It also allows us to use DNA based techniques to allotype C3 in subjects with little or no C3 in their serum...
  95. ncbi Duplication and concerted evolution of the mitochondrial control region in the parrot genus Amazona
    J R Eberhard
    Smithsonian Tropical Research Institute, Balboa, Panama
    Mol Biol Evol 18:1330-42. 2001
    ....
  96. ncbi Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of rhesus monkeys
    S Sopper
    Institut fur Virologie und Immunbiologie, Universitat Wurzburg, Germany
    Cytometry 29:351-62. 1997
    ..In contrast, a higher proportion of B-cells in LN stains positive for CD21 and CD35...
  97. ncbi Philadelphia chromosome-positive (Ph+) childhood acute lymphoblastic leukemia: good initial steroid response allows early prediction of a favorable treatment outcome
    M Schrappe
    Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Hannover, Germany
    Blood 92:2730-41. 1998
    ..55 (SE, 0.08) compared with 0.10 (SE, 0.07) in patients with PPR (P = .0001). PGR is also an indicator for treatment responsiveness and durable second remission after relapse, which in turn may provide a second chance for BMT...
  98. ncbi The effects of bovine serum albumin and fetal bovine serum on the development of pre- and postcleavage-stage bovine embryos cultured in modified CR2 and M199 media
    S Wang
    Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322 9400, USA
    Anim Reprod Sci 48:37-45. 1997
    ..In M199, 24 transferred blastocysts resulted in five pregnancies and the birth of two normal calves. There was no difference (p > 0.05) in rate of embryo development between CR2 and M199...
  99. ncbi The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens
    A Cherukuri
    National Institute of Allergy and Infectious Diseases, Laboratory of Immunogenetics, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 167:163-72. 2001
    The CD19/CD21 complex is an essential B cell coreceptor that functions synergistically to enhance signaling through the B cell Ag receptor in response to T cell-dependent, complement-tagged Ags...

Research Grants63

  1. Follicular dendritic cell activation and HIV pathogenesis
    Gregory F Burton; Fiscal Year: 2010
    ..FDCs trap ICs (including HIV) using CD32 (Fc?RIIB) and CD21 (Complement Receptor 2), although other as yet unknown receptors may also make contributions in the case of HIV-IC...
  2. Loss of B cell tolerance in rheumatoid arthritis
    Eric Meffre; Fiscal Year: 2013
    ..increased frequency of peripheral unresponsive autoreactive B cells, which do not express the complement receptor 2/CD21 and are refractory to BCR and CD40 triggering...
  3. Analysis of Lupus Susceptibility Genes for Treatment and Prevention of Disease
    Susan A Boackle; Fiscal Year: 2013
    ..The candidate has demonstrated that complement receptor 2 (CR2/CD21) is a strong candidate gene for lupus susceptibility in the NZM2410 mouse model of lupus as well as in human ..
  4. CD81 AND B CELL ANTIGEN RECEPTOR SIGNALING
    Erdyni Tsitsikov; Fiscal Year: 2002
    ..of this project is to analyze the role of CD81, a component of the complement receptor 2 (CR2) complex, along with CD21, CD19 and Leu13, in signaling via the B cell antigen receptor (BCR)...
  5. REGULATION OF COMPLEMENT RECEPTOR GENE EXPRESSION
    George Tsokos; Fiscal Year: 2002
    ..Since we have found that sera from patients with systemic autoimmune diseases have antibodies directed against this hnRNP, we propose to study their frequency and clinical significance. ..
  6. REGULATION OF HUMORAL IMMUNITY BY COMPLEMENT RECEPTORS
    Hector Molina; Fiscal Year: 2001
    ..Following backcrossing into CR1/CR2 deficient mice, the immune response to different antigens will then be evaluated. These experiments will clarify the different roles of these proteins in the immune response. ..
  7. Targeted Complement Inhibitors as Therapeutic Agents
    WOODRUFF EMLEN; Fiscal Year: 2005
    ..abstract_text> ..
  8. Disconnecting CR2/CD21 from Its C3d Ligand to Ameliorate Lupus
    VERNON MICHAEL HOLERS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Complement receptor type 2 (CR2/CD21) and its primary C3 activation fragment-derived ligand designated C3d play a central role in the development of high affinity antibodies to foreign antigens...
  9. REGULATION OF CR2/CD21 EXPRESSION AND ACTIVATION
    JOHN WEIS; Fiscal Year: 2012
    The murine CD21/Cr2 gene encodes two proteins implicated in the acquisition of an optimal immune response...
  10. COMPLEMENT SYSTEM AND HUMORAL IMMUNITY
    MICHAEL CRAIG CARROLL; Fiscal Year: 2013
    ..and shuttled to the underlying B cells where they are captured by cognate B or bound by naive B cells via CD21 receptor. How the antigen is transferred to the FDC remains unclear...
  11. Criteria-Directed Vaccine Generation Via Ag Mimicry, Adjuvancy, And APC-Targeting
    Timothy J Sellati; Fiscal Year: 2013
    ....
  12. Novel Carrier for Polysaccharide Conjugates and an EBV Vaccine
    CLIFFORD SNAPPER; Fiscal Year: 2009
    ..The EBV protein, gp350, is the major target for EBV neutralizing antibody, as well as a ligand for CD21, a potent co-activator of the B cell antigen receptor...
  13. COMPLEMENT C3 AND ACQUIRED AND INNATE IMMUNITY
    Michael Carroll; Fiscal Year: 2003
    ..is covalent attachment of activated C3 to pathogen surface as this provides a ligand for complement receptors CD21 and CD35 which are expressed on follicular dendritic cells and certain leukocytes including B lymphocytes and ..
  14. Early events in infection of epithelial cells with Epstein-Barr Virus
    SARAH M VALENCIA; Fiscal Year: 2011
    ..in a B cell, but can involve interactions between the virus glycoprotein gp350 and the cell protein complement receptor type 2 (CR2 or CD21) and between the virus glycoprotein complex gHgL and the BMRF2 protein and cellular ..
  15. HO-1 and granuloma formation in TB pleurisy
    Veena B Antony; Fiscal Year: 2010
    ....
  16. TARGETING AML-STROMAL INTERACTIONS
    John F DiPersio; Fiscal Year: 2013
    ..We hypothesize that pharmacologic interruption of the tethers that bind AML blasts to the bone marrow will sensitize these cells to chemotherapy and improve remission rates and long term disease free survival. ..
  17. Formins (FHOS) in CD21-mediated signaling & virus entry
    Joyce Fingeroth; Fiscal Year: 2009
    Human CD21 is an innate immune system receptor (C3dg receptor or complement receptor type 2, CR2) and is a key modulator of the acquired immune response. CD21 is also the high affinity receptor for EBV...
  18. Key molecular mechanisms of extraneural pathogenesis and transmission of TSEs
    Mark D Zabel; Fiscal Year: 2012
    ..1) previously published data demonstrating that partial or complete depletion of Complement components C1q, C3 and CD21 delays splenic prion accumulation and replication;and impedes or even prevents disease in murine models of scrapie;..
  19. Complement in the Pathogenesis of Autoimmune Arthritis
    VERNON MICHAEL HOLERS; Fiscal Year: 2013
    ..abstract_text> ..
  20. MOLECULAR ANALYSIS OF B-LYMPHOCYTE RESTRICTED PROTEINS
    Thomas Tedder; Fiscal Year: 2002
    ..a B lymphocyte cell-surface receptor that is a central component of a signal transducing complex that includes CD21, a receptor for the C3d complement fragment...
  21. EBV Entry and Spread in the Oral Cavity
    Lindsey M Hutt-Fletcher; Fiscal Year: 2013
    ..Unraveling mechanisms by which virus is targeted to cells newly prone to infection is important to understanding pathogenesis and developing evasive strategies ..
  22. Complement-mediated injury of the kidney: New mechanisms and novel therapies
    Joshua M Thurman; Fiscal Year: 2013
    ..The studies in this grant are significant because they examine a process central to the pathogenesis of a wide range of renal diseases and provide new treatment strategies for these diseases. ..
  23. 7 Tesla MRI Bolus CR Studies of Human BBB Permeability
    Charles S Springer; Fiscal Year: 2013
    ..Though this project will study the normal and multiple sclerosis (MS) human brain, SSM DCE-MRI also applies to cancer in all areas of the body, to studies of normal and diseased human myocardium, and to many other pathologies. ..
  24. Association of Positional Candidate Gene Variants with SLE
    Betty P Tsao; Fiscal Year: 2012
    ..The identification of novel genes common to multiple ethnic groups will yield new insights into the mechanisms underlying the disease, which may lead to the development of specific targets for therapeutic interventions. ..
  25. AIDS ASSOCIATED LEUKOPLAKIA--ROLE OF EBV
    Nancy Raab Traub; Fiscal Year: 2004
    ..with virus produced by lymphoid or epithelial cells, or whether entry is mediated by the known viral receptor, CD21, or by co-cultivation...
  26. Synthesis and Evaluation of Sigma-Active Cocaine Antagonists
    Rae R Matsumoto; Fiscal Year: 2010
    ..It is anticipated that the results of this project will stimulate the rational development of new a2 receptor probes and ultimately contribute to improved treatments for psychostimulant abuse. ..
  27. The Structural basis of EBV Attachment: CD21 & gp350/220
    Joyce Fingeroth; Fiscal Year: 2005
    ..However, although the EBV receptor (CR2/CD21) was identified almost 20 years ago, the structural basis for the interaction of CD21 with its EBV ..
  28. EBV AND ORAL IMMUNOPATHOLOGY IN SJOGREN'S SYNDROME
    JOSEPH AHEARN; Fiscal Year: 1999
    ..human SS, 3) the immunopathogenesis of murine models of 55, 4) the molecular biology of EBV and its receptor CR2 (CD21), and 5) the cellular and molecular biology of T lymphocyte responses to viral infections...
  29. TRANSGENIC MOUSE MODELS FOR STUDYING PROSTATE/GU DISEASE
    Jeffrey Gordon; Fiscal Year: 2002
    ..These mice will allow future tests of the contributions of various genes to urothelial function in health and disease. ..
  30. LIPOCORTINS (ANNEXINS) AND METAL-INDUCED MUTAGENESIS
    Fusao Hirata; Fiscal Year: 2003
    ..Our proposed research will provide further insights to understanding of the molecular mechanisms of carcinogenesis, genetic instability and pathological diseases associated with the formation of mutations by heavy metals. ..
  31. CRYPTDIN EFFECTS ON CRYPT EPITHELIA
    Wayne Lencer; Fiscal Year: 2004
    ....
  32. MOLECULAR BIOLOGY OF INFLAMMATION AND HOST DEFENSE
    PER PETERSON; Fiscal Year: 1991
    ..Another membrane protein with host protective function, homologous restriction factor, will also be isolated and studied...
  33. Complement Regulates the Humoral Response to HIV-1
    Michael M Frank; Fiscal Year: 2010
    ..The binding of classical pathway proteins, but surprisingly not alternative pathway proteins, directs antigens to CD21, the C3d receptor, on MZ cells...
  34. RHEUMATIC DISEASE--CORE CENTER
    Peter Schur; Fiscal Year: 1992
    ....
  35. ROLE OF COMPLEMENT RECEPTOR IN THE IMMUNE RESPONSE
    Douglas Fearon; Fiscal Year: 1992
    ..Demonstration of these reactions would provide a model that describes a role for complement in antigen-specific activation of T cells, and in T cell-dependent, antigen-non-specific, polyclonal B cell activation...
  36. PUTATIVE MURINE COMPLEMENT RECEPTOR TYPE 2
    Joyce Fingeroth; Fiscal Year: 1992
    ..Comparison of the human and murine receptor should provide insight into the different structural requirements for EBV and C3d attachment...
  37. Targeting complement inhibitors to the human proximal tubule
    Richard Quigg; Fiscal Year: 2007
    ..Although these are considered pilot and high-risk studies, successful completion could give us treatments for immediate use in clinical studies. [unreadable] [unreadable] [unreadable]..
  38. TARGETING TO LYMPHOCYTES MEDIATED BY SYNTHETIC EPITOPES
    Jindrich Kopecek; Fiscal Year: 2004
    ..The EDPGFFNVE nonapeptide (NP) was recognized as the CD21 (CR2) binding epitope of the Epstein-Barr virus (EBV) gp350/220 envelope glycoprotein, which mediates the virus ..
  39. Structural Studies of CR2 Interaction with EBVgp350
    Xiaojiang Chen; Fiscal Year: 2006
    b>Complement receptor type 2 (CR2/CD21) is a cell surface receptor that functions in diverse biological processes that include activating B-cell and T-dependent humoral immune responses, maintaining long-term B-cell memory and mediating ..
  40. Isolation of narrow subpopulations of cells using molecular computing cascades
    Milan N Stojanovic; Fiscal Year: 2013
    ..model system, we will demonstrate the ability to isolate narrow subpopulations of conventional memory B-cells (CD19+CD21+CD27+IgD-) and recently characterized unconventional memory B-cells (CD19+CD21-/lowCD27-IgD-CD95+)...
  41. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2006
    ..the hypothesis that the interaction between anti-CD1 reactive NK T cells and marginal zone B cells (IgM(hi) IgD(lo) CD21(hi) CD1(hi)) via CD1 is a critical step in the pathogenesis of lupus in two mouse models; hereditary lupus in NZB/..
  42. FUNCTIONAL MAPPING OF THE HUMANS C3D RECEPTOR CR2
    JANIS WEIS; Fiscal Year: 1990
    Human complement receptor type 2, CR2, is the B lymphocyte receptor for the d region of the third component of complement...
  43. INITIATION OF CELL INFECTION BY EPSTEIN-BARR VIRUS
    Lindsey Hutt Fletcher; Fiscal Year: 2004
    ..A current model proposes that virus uses minimally an attachment protein gp350/220 which binds to the complement receptor type 2 (CR2) and a complex of three glycoproteins gH-gL-gp42 which is involved in penetration...
  44. TARGETING THE CXCR4-SDF1 AXIS AS THERAPY FOR RELAPSED/REFRACTORY AML
    John F DiPersio; Fiscal Year: 2010
    ..This will be used to treat patients with relapsed AML to improve outcomes. ..
  45. REGULATION OF CBP/P300 IN NUCLEAR RECEPTOR FUNCTION
    Debabrata Chakravarti; Fiscal Year: 2004
    ..abstract_text> ..
  46. BCR MEDIATED SIGNALING AND CYCLING B CELL BIOLOGY
    E Snow; Fiscal Year: 2001
    ..In the first specific aim, experiments are outlined to test the hypothesis that the CD19/CD21 co-receptor plays an important role during delivery of this initial survival signal to cycling B cells...
  47. Cr2 as a Murine Lupus Susceptibility Gene
    SUSAN BOACKLE; Fiscal Year: 2002
    ..corresponding to Sle1c, derived from NZW, contains Cr2, which encodes complement receptors 1 and 2 (CR1/CR2, CD35/CD21). CR1/CR2 deficiency has been associated with autoimmune disease in both humans and in animal models...
  48. ROLE OF TRANSCRIPTION FACTOR EGR1 IN PROSTATE CANCER
    SARKI ABDULKADIR; Fiscal Year: 2004
    ..The immediate goal is to train in a high-quality research environment and to develop tools and techniques that will prepare the Principal Investigator for a successful academic pathology career. ..
  49. B Cell Presentation of HIV
    David H Schwartz; Fiscal Year: 2010
    ..cultures reflects HIV binding to B cell surface membrane via DC-SIGN, CD40, LFA-1, and (in the presence of C3d) CD21. 3) Contact-dependent B cell presentation of HIV to purified autologous and allogeneic T cells, MDMs, and ..
  50. Role of the Fragilis Proteins in the Immune Response
    JOHN WEIS; Fiscal Year: 2005
    ..These proteins represent yet another bridge between the molecules that function within the antigen specific response (B cell receptor, T cell receptor, etc) and those of the innate immune response. ..
  51. DETERMINANTS OF EPSTEIN BARR VIRUS MUCOSAL PATHOGENESIS
    John Sixbey; Fiscal Year: 2000
    ..data to suggest that epithelial cell polarity may play a role, whether the uptake of EBV is mediated by the EBV receptor CR2 or by IgA modulation of infection...
  52. COMPLEMENT AND B CELL TOLERANCE IN A MURINE MODEL OF SLE
    Elahna Paul; Fiscal Year: 2002
    ..genetic background (mixed C57BL/6 and 129), even isolated deficiency of C4 (C4^-/-) or of its receptor CD21/CD35 (Cr2^-/-) are risk factors for developing autoantibodies to DNA...
  53. MECHANISMS OF ANTIBODY MEDIATED ALLOGRAFT REJECTION
    Barbara Wasowska; Fiscal Year: 2003
    ..4. P-selectin augments activation of endothelial cells, platelets and macrophages in allograft rejection. ..
  54. Functional Analysis of Complement Receptor 2 as a Lupus Susceptibility Gene
    Susan A Boackle; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Complement receptor 2 (CR2/CD21) is the strongest candidate gene for lupus susceptibility in the Sle 1c lupus susceptibility interval of the NZM2410 mouse model of lupus, based on structural and ..
  55. Cr2 as a Murine Lupus Susceptibility Gene
    SUSAN BOACKLE; Fiscal Year: 2007
    ..corresponding to Slelc, derived from NZW, contains Cr2, which encodes complement receptors I and 2 (CR1/CR2, CD35/CD21). CR1/CR2 deficiency has been associated with autoimmune disease in both humans and in animal models...
  56. Complement Receptor 2 as a Biomarker for Systemic Lupus Erythematosus
    SUSAN BOACKLE; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Complement receptor 2 (CR2/CD21) is the strongest candidate gene for lupus susceptibility in the Slelc lupus susceptibility interval of the NZM2410 mouse model of lupus, based on ..
  57. C3D/EBV RECEPTOR LIGAND BINDING SITES
    V Holers; Fiscal Year: 2006
    Human complement receptor type 2 (CR2/CD21) is an ~145 Kd Type I transmembrane protein that serves as a receptor for three classes of ligands...
  58. MOUSE MEMBRANE RCA PROTEINS IN THE IMMUNE RESPONSE
    V Holers; Fiscal Year: 2008
    ..Two of these receptors, complement receptor type 1 (CR1/CD35) and type 2 (CR2/CD21), are members of a family of structurally related proteins called the Regulators of Complement Activation (RCA)...
  59. Co-stimuli for Human Marginal Zone B Cell Activation
    Patricia Mongini; Fiscal Year: 2004
    ..This proposal is based on the hypothesis that several facets of MZ B cells (i.e. heightened levels of C3dg-binding CD21, their proximity and sensitivity to BAFF, and their proximity and possible sensitivity to Toll-like receptor (TLR)-..
  60. DENVER AUTOIMMUNITY CENTER OF EXCELLENCE
    V Holers; Fiscal Year: 2007
    ..This latter project involves a newly established collaboration with a separate institution and group of clinicians skilled in the clinical investigation of RA. ..
  61. Transgenic Rod Development and Function
    Baerbel Rohrer; Fiscal Year: 2005
    ..However, more importantly, it will provide avenues for studying gene defects at the single cell level not only in the retina, but in other systems as well. ..
  62. ROD NEURODEGENERATIVE AND PROTECTIVE GENES
    Baerbel Rohrer; Fiscal Year: 2005
    ..We expect to isolate common downstream target genes that are activated both during degeneration and neuroprotection. ..
  63. Evolution of Autoimmunity in Rheumatoid Arthritis
    V Holers; Fiscal Year: 2005
    ..abstract_text> ..