CD1D

Summary

Gene Symbol: CD1D
Description: CD1d molecule
Alias: CD1A, R3G1, antigen-presenting glycoprotein CD1d, CD1D antigen, d polypeptide, HMC class I antigen-like glycoprotein CD1D, T-cell surface glycoprotein CD1d, differentiation antigen CD1-alpha-3, thymocyte antigen CD1D
Species: human
Products:     CD1D

Top Publications

  1. Brutkiewicz R. CD1d ligands: the good, the bad, and the ugly. J Immunol. 2006;177:769-75 pubmed
    The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells...
  2. McNab F, Berzins S, Pellicci D, Kyparissoudis K, Field K, Smyth M, et al. The influence of CD1d in postselection NKT cell maturation and homeostasis. J Immunol. 2005;175:3762-8 pubmed
    After being positively selected on CD1d-expressing thymocytes, NKT cells undergo a series of developmental changes that can take place inside or outside the thymus...
  3. Chang D, Deng H, Matthews P, Krasovsky J, Ragupathi G, Spisek R, et al. Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer. Blood. 2008;112:1308-16 pubmed publisher
    b>CD1d-restricted T cells have been implicated in the pathogenesis of several chronic inflammatory states...
  4. Kang S, Cresswell P. Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells. Nat Immunol. 2004;5:175-81 pubmed
    ..Here we show that saposins, although not required for the autoreactive recognition of CD1d by natural killer T cells, are indispensable for the binding of an exogenous lipid antigen, alpha-..
  5. Im J, Yu K, Illarionov P, LeClair K, Storey J, Kennedy M, et al. Direct measurement of antigen binding properties of CD1 proteins using fluorescent lipid probes. J Biol Chem. 2004;279:299-310 pubmed
    ..To increase stability and yield, soluble group 1 CD1 (CD1b and CD1c) and group 2 CD1 (CD1d) proteins were produced as single chain secreted CD1 proteins in which beta2-microglobulin was fused to the N ..
  6. Wang J, Li Y, Kinjo Y, Mac T, Gibson D, Painter G, et al. Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proc Natl Acad Sci U S A. 2010;107:1535-40 pubmed publisher
    Invariant natural killer T cells (iNKT cells) respond to CD1d-presented glycolipids from Borrelia burgdorferi, the causative agent of Lyme disease...
  7. Moll M, Andersson S, Smed Sorensen A, Sandberg J. Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments. Blood. 2010;116:1876-84 pubmed publisher
    ..Interaction between DCs and the innate-like CD1d-restricted natural killer T (NKT) cells results in the mutual activation of both cells and the subsequent ..
  8. van de Wal Y, Corazza N, Allez M, Mayer L, Iijima H, Ryan M, et al. Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells. Gastroenterology. 2003;124:1420-31 pubmed
    b>CD1d, a major histocompatibility complex (MHC) class I-related molecule that is responsible for the presentation of glycolipid antigens to subsets of natural killer T (NK-T) cells, is expressed by intestinal epithelial cells (IECs)...
  9. Miura S, Kawana K, Schust D, Fujii T, Yokoyama T, Iwasawa Y, et al. CD1d, a sentinel molecule bridging innate and adaptive immunity, is downregulated by the human papillomavirus (HPV) E5 protein: a possible mechanism for immune evasion by HPV. J Virol. 2010;84:11614-23 pubmed publisher
    b>CD1d and CD1d-restricted natural killer T (NKT) cells serve as a natural bridge between innate and adaptive immune responses to microbes. CD1d downregulation is utilized by a variety of microbes to evade immune detection...

More Information

Publications85

  1. Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, Motoki K, et al. CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science. 1997;278:1626-9 pubmed
    ..Valpha14 NKT cells were abrogated by treatment with chloroquine-concanamycin A or by monoclonal antibodies against CD1d/Vbeta8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated ..
  2. Kang S, Cresswell P. Regulation of intracellular trafficking of human CD1d by association with MHC class II molecules. EMBO J. 2002;21:1650-60 pubmed
    ..Here we show that a subset of human CD1d molecules are associated with major histocompatibility complex (MHC) class II molecules, both on the cell surface ..
  3. Sikder H, Zhao Y, Balato A, Chapoval A, Fishelevich R, Gade P, et al. A central role for transcription factor C/EBP-beta in regulating CD1d gene expression in human keratinocytes. J Immunol. 2009;183:1657-66 pubmed publisher
    b>CD1d is a nonclassical Ag-presenting molecule that presents glycolipid Ags to NKT cells that are involved in immune defense and tumor rejection. It also plays a role in immunoregulatory functions in the epidermis...
  4. Cox D, Fox L, Tian R, Bardet W, Skaley M, Mojsilovic D, et al. Determination of cellular lipids bound to human CD1d molecules. PLoS ONE. 2009;4:e5325 pubmed publisher
    ..Here we have molecularly characterized lipids bound to the human CD1d isoform...
  5. Lopez Sagaseta J, Sibener L, Kung J, Gumperz J, Adams E. Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor. EMBO J. 2012;31:2047-59 pubmed publisher
    ..T (iNKT) cells use highly restricted αβ T cell receptors (TCRs) to probe the repertoire of lipids presented by CD1d molecules...
  6. Yue S, Shaulov A, Wang R, Balk S, Exley M. CD1d ligation on human monocytes directly signals rapid NF-kappaB activation and production of bioactive IL-12. Proc Natl Acad Sci U S A. 2005;102:11811-6 pubmed
    Natural killer T cells (NKT cells) expressing a semi-invariant CD1d-reactive T cell receptor (invariant NKT, iNKT) can be rapidly activated by monocytes or immature dendritic cells (iDCs) bearing a CD1d-presented glycolipid antigen and ..
  7. Haraguchi K, Takahashi T, Nakahara F, Matsumoto A, Kurokawa M, Ogawa S, et al. CD1d expression level in tumor cells is an important determinant for anti-tumor immunity by natural killer T cells. Leuk Lymphoma. 2006;47:2218-23 pubmed
    ..Human iNKT (i.e. Valpha24+ NKT) cells have been reported to recognize CD1d on target cells and show cytotoxicity directly on the target cells in vitro...
  8. Cho S, Knox K, Kohli L, He J, Exley M, Wilson S, et al. Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex. Virology. 2005;337:242-52 pubmed
    ..of the innate immune response, we assessed the ability of Nef to alter the cell surface expression of human CD1d. In cells co-expressing CD1d and Nef, a substantial reduction in the cell surface level of CD1d was observed, with ..
  9. Koch M, Stronge V, Shepherd D, Gadola S, Mathew B, Ritter G, et al. The crystal structure of human CD1d with and without alpha-galactosylceramide. Nat Immunol. 2005;6:819-26 pubmed
    The glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic alpha-galactosylceramide at a resolution of 3.0 A...
  10. Jayawardena Wolf J, Benlagha K, Chiu Y, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001;15:897-908 pubmed
    ..We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs ..
  11. Chen N, McCarthy C, Drakesmith H, Li D, Cerundolo V, McMichael A, et al. HIV-1 down-regulates the expression of CD1d via Nef. Eur J Immunol. 2006;36:278-86 pubmed
    ..Here we report that Nef also reduces the expression of the non-classical MHC-I like CD1d molecule, a third lineage of antigen-presenting molecule, which presents lipid antigens...
  12. Constantinides M, Picard D, Savage A, Bendelac A. A naive-like population of human CD1d-restricted T cells expressing intermediate levels of promyelocytic leukemia zinc finger. J Immunol. 2011;187:309-15 pubmed publisher
    Rare CD1d-?-galactosylceramide-specific T cells that do not express the invariant V?24 chain of human NKT cells were recently identified after expansion in vitro with the lipid Ag, but their phenotype and frequency in vivo and lineage ..
  13. Wu D, Xing G, Poles M, Horowitz A, Kinjo Y, Sullivan B, et al. Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells. Proc Natl Acad Sci U S A. 2005;102:1351-6 pubmed
    ..Moreover, CD1d-dimer staining revealed human NKT cell reactivity toward these GSLs and to the sulfatides in a fashion comparable ..
  14. Somnay Wadgaonkar K, Nusrat A, Kim H, Canchis W, Balk S, Colgan S, et al. Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form. Int Immunol. 1999;11:383-92 pubmed
    In order to better understand the role of intestinal CD1d, we sought to define the cellular localization and further characterize the biochemical structure of CD1d in human intestinal epithelial cells (IEC)...
  15. Chen X, Wang X, Keaton J, Reddington F, Illarionov P, Besra G, et al. Distinct endosomal trafficking requirements for presentation of autoantigens and exogenous lipids by human CD1d molecules. J Immunol. 2007;178:6181-90 pubmed
    b>CD1d molecules present both self Ags and microbial lipids to NKT cells. Previous studies have established that CD1d lysosomal trafficking is required for presentation of autoantigens to murine invariant NKT cells...
  16. Balk S, Burke S, Polischuk J, Frantz M, Yang L, Porcelli S, et al. Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. Science. 1994;265:259-62 pubmed
    A major histocompatibility complex class Ib protein, CD1d, is expressed by human intestinal epithelial cells (IECs) and is a ligand for CD8+ T cells...
  17. Vincent M, Leslie D, Gumperz J, Xiong X, Grant E, Brenner M. CD1-dependent dendritic cell instruction. Nat Immunol. 2002;3:1163-8 pubmed
    ..Distinct CD1-reactive T cells may thus differentially direct DC development early in the immune response, thereby controlling subsequent polarization of acquired immunity. ..
  18. Blumberg R, Terhorst C, Bleicher P, McDermott F, Allan C, Landau S, et al. Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells. J Immunol. 1991;147:2518-24 pubmed
    The human CD1 locus encodes three nonpolymorphic MHC class I-like cell surface glycoproteins, CD1a-c, which are expressed primarily by immature thymocytes...
  19. Hage C, Kohli L, Cho S, Brutkiewicz R, Twigg H, Knox K. Human immunodeficiency virus gp120 downregulates CD1d cell surface expression. Immunol Lett. 2005;98:131-5 pubmed
    b>CD1d is an MHC class I-like surface molecule that presents endogenous glycoplipid antigens. The effect of HIV infection on CD1d surface expression has not yet been reported...
  20. Paduraru C, Spiridon L, Yuan W, Bricard G, Valencia X, Porcelli S, et al. An N-linked glycan modulates the interaction between the CD1d heavy chain and beta 2-microglobulin. J Biol Chem. 2006;281:40369-78 pubmed
    Human CD1d molecules consist of a transmembrane CD1 (cluster of differentiation 1) heavy chain in association with beta(2)-microglobulin (beta(2)m)...
  21. Yuan W, Qi X, Tsang P, Kang S, Illarionov P, Illaniorov P, et al. Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules. Proc Natl Acad Sci U S A. 2007;104:5551-6 pubmed
    b>CD1d molecules bind lipid antigens in the endocytic pathway, and access to the pathway is important for the development of CD1d-restricted natural killer T (NKT) cells...
  22. Chen Q, Jackson N. Human CD1D gene has TATA boxless dual promoters: an SP1-binding element determines the function of the proximal promoter. J Immunol. 2004;172:5512-21 pubmed
    b>CD1d presents lipid Ags to a specific population of NK T cells, which are involved in the host immune defense, suppression of autoimmunity, and the rejection of tumor cells...
  23. Brigl M, van den Elzen P, Chen X, Meyers J, Wu D, Wong C, et al. Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors. J Immunol. 2006;176:3625-34 pubmed
    b>CD1d-restricted NKT cells use structurally conserved TCRs and recognize both self and foreign glycolipids, but the TCR features that determine these Ag specificities remain unclear...
  24. Borg N, Wun K, Kjer Nielsen L, Wilce M, Pellicci D, Koh R, et al. CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature. 2007;448:44-9 pubmed
    ..express a semi-invariant T-cell receptor (NKT TCR) that specifically recognizes the CD1 family member, CD1d. NKT-cell-mediated recognition of the CD1d-antigen complex has been implicated in microbial immunity, tumour ..
  25. Wun K, Borg N, Kjer Nielsen L, Beddoe T, Koh R, Richardson S, et al. A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR. J Exp Med. 2008;205:939-49 pubmed publisher
    ..Using the structure of the human semiinvariant NKT TCR-CD1d-alpha-galactosylceramide (alpha-GalCer) complex as a guide, we undertook an alanine scanning mutagenesis approach ..
  26. Brigl M, Brenner M. CD1: antigen presentation and T cell function. Annu Rev Immunol. 2004;22:817-90 pubmed
    ..T cells play important roles and reveal differences in the role of CD1a, CD1b, and CD1c in contrast to CD1d. Invariant TCR alpha chains, self-lipid reactivity, and rapid effector responses empower a subset of CD1d-..
  27. Kang S, Cresswell P. Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain. J Biol Chem. 2002;277:44838-44 pubmed
    ..Unlike major histocompatibility complex class I or CD1b molecules, which need beta(2)m to exit the ER, CD1d can be expressed on the cell surface as either a free heavy chain or associated with beta(2)m...
  28. Liu J, Shaji D, Cho S, Du W, Gervay Hague J, Brutkiewicz R. A threonine-based targeting signal in the human CD1d cytoplasmic tail controls its functional expression. J Immunol. 2010;184:4973-81 pubmed publisher
    b>CD1d molecules are MHC class I-like molecules that present lipids to a unique subpopulation of T cells called NKT cells. The cytoplasmic tail of human CD1d possesses a tyrosine-based endosomal targeting motif (YXXZ)...
  29. Kojo S, Adachi Y, Tsutsumi A, Sumida T. Alternative splicing forms of the human CD1D gene in mononuclear cells. Biochem Biophys Res Commun. 2000;276:107-11 pubmed
    b>CD1d is a critical molecule for the presentation of lipid antigens to natural killer (NK) T cells...
  30. De Silva A, Park J, Matsuki N, Stanic A, Brutkiewicz R, Medof M, et al. Lipid protein interactions: the assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum. J Immunol. 2002;168:723-33 pubmed
    ..In this manner, cellular lipids might play a chaperone-like role in the assembly of CD1d1 in vivo, akin to the function of invariant chain in MHC class II assembly...
  31. Han X, Yang J, Zhang Y, Zhang Y, Cao H, Cao Y, et al. Potential Role for Regulatory B Cells as a Major Source of Interleukin-10 in Spleen from Plasmodium chabaudi-Infected Mice. Infect Immun. 2018;86: pubmed publisher
    ..The well-established Breg subset, CD19+ CD5+ CD1dhi cells, accounted for less than 20% of IL-10-producing B cells in both strains during the course of ..
  32. Kosten I, Spiekstra S, de Gruijl T, Gibbs S. MUTZ-3 Langerhans cell maturation and CXCL12 independent migration in reconstructed human gingiva. ALTEX. 2016;33:423-434 pubmed publisher
    ..of GE-LC resulted in an increase in MUTZ-3 LC and CD83 mRNA in the hydrogel but did not result in an increase in CD1a+ cells in the collagen hydrogel (as was observed for SE-LC...
  33. Zhang S, Song W, Gao Y, Yang B, Du Z. CD1d gene is a target for a novel amplicon at 1q22-23.1 in human hepatocellular carcinoma. Mol Biol Rep. 2010;37:381-7 pubmed publisher
    ..1% (23/41) HCC samples at 1q21 and 80.5% (33/41) at 1q22-23.1. Wilcoxon signed rank test showed expression of CD1d, which located at amplicon of 1q22-23...
  34. Laganà A, Triolo O, Salmeri F, Granese R, Palmara V, Ban Frangež H, et al. Natural Killer T cell subsets in eutopic and ectopic endometrium: a fresh look to a busy corner. Arch Gynecol Obstet. 2016;293:941-9 pubmed publisher
    ..a specialized subset of T cells that use their T cell receptor to recognize self and foreign lipids presented by CD1d as cognate antigens...
  35. Van Rhijn I, Moody D. Donor Unrestricted T Cells: A Shared Human T Cell Response. J Immunol. 2015;195:1927-32 pubmed publisher
    ..However, other T cells can be considered "donor unrestricted" because their targets, CD1a, CD1b, CD1c, CD1d, or MR1, are expressed in a similar form among all humans...
  36. Lexmond W, Neves J, Nurko S, Olszak T, Exley M, Blumberg R, et al. Involvement of the iNKT cell pathway is associated with early-onset eosinophilic esophagitis and response to allergen avoidance therapy. Am J Gastroenterol. 2014;109:646-57 pubmed publisher
    ..in life determine susceptibility to allergic diseases through inappropriate chemotaxis and local activation of CD1d-restricted, invariant chain natural killer T (iNKT) cells...
  37. McCarthy C, Shepherd D, Fleire S, Stronge V, Koch M, Illarionov P, et al. The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. J Exp Med. 2007;204:1131-44 pubmed
    b>CD1d-restricted lymphocytes recognize a broad lipid range. However, how CD1d-restricted lymphocytes translate T cell receptor (TCR) recognition of lipids with similar group heads into distinct biological responses remains unclear...
  38. Pellicci D, Uldrich A, Le Nours J, Ross F, Chabrol E, Eckle S, et al. The molecular bases of δ/αβ T cell-mediated antigen recognition. J Exp Med. 2014;211:2599-615 pubmed publisher
    ..Vδ1(+) human T cells, can recognize peptide- and lipid-based Ags presented by human leukocyte antigen (HLA) and CD1d, respectively...
  39. Borg Z, Benoit P, Lilley G, Aktan I, Chant A, Devault V, et al. Polymorphisms in the CD1d promoter that regulate CD1d gene expression are associated with impaired NKT cell development. J Immunol. 2014;192:189-99 pubmed publisher
    b>CD1d-restricted NKT cells comprise an innate-like T cell population that exerts significant influence over early events in the developing immune response...
  40. Oh S, Lee H, Shin J, Hong C, Park S. Murine CD8+ Invariant Natural Killer T Cells are Negatively Selected by CD1d Expressed on Thymic Epithelial Cells and Dendritic Cells. Immunol Invest. 2017;:1-12 pubmed publisher
    b>CD1d-dependent invariant natural killer (iNKT) cells are found as either CD4 single positive (SP) or CD4/CD8 double negative (DN) cells in mice. The size of the CD8+ iNKT population is extremely small...
  41. Zhang L, Donda A. Alpha-Galactosylceramide/CD1d-Antibody Fusion Proteins Redirect Invariant Natural Killer T Cell Immunity to Solid Tumors and Promote Prolonged Therapeutic Responses. Front Immunol. 2017;8:1417 pubmed publisher
    ..innate and adaptive immunity, we have developed a bi-functional protein composed of the extracellular part of CD1d molecule that was genetically fused to an scFv fragment from high affinity antibodies against HER2 or CEA...
  42. Wang Y, Shang S, Sun Q, Chen J, Du G, Nie H, et al. Increased infiltration of CD11 c+/CD123+ dendritic cell subsets and upregulation of TLR/IFN-α signaling participate in pathogenesis of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:459-467.e2 pubmed publisher
    ..DC1 [mDC1], CD141+mDC2, CD11c-CD123+plasmacytoid DC [pDC], and CD1a+CD207+Langerhans cells [LC]) were investigated via flow cytometry (FCM) and ..
  43. Hu X, Tai J, Qu Z, Zhao S, Zhang L, Li M, et al. A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. PLoS ONE. 2016;11:e0152368 pubmed publisher
    ..In contrast, the numbers of CD5+CD19+, IL-10+CD19+, CD5+CD1d+CD19+, and IL-10+CD5+CD1d+CD19+ B cells per microliter of blood and the serum IL-10 concentration were ..
  44. Mardi K, Thakur R, Negi L. Intradural Eosinophilic Granuloma Invading Skull: Case Report and Review of the Literature. Asian J Neurosurg. 2017;12:698-700 pubmed publisher
    ..Right parietal extended craniotomy was done with the excision of mass from the dura. Histopathological features of mass were characteristic of eosinophilic granuloma which was confirmed by positive immunohistochemical staining for CD1a.
  45. Tocheva A, Mansour S, Holt T, Jones S, Chancellor A, Sanderson J, et al. The Clonal Invariant NKT Cell Repertoire in People with Type 1 Diabetes Is Characterized by a Loss of Clones Expressing High-Affinity TCRs. J Immunol. 2017;198:1452-1459 pubmed publisher
    Invariant NKT (iNKT) cells in healthy people express iNKT-TCRs with widely varying affinities for CD1d, suggesting different roles for high- and low-affinity iNKT clones in immune regulation...
  46. Li X, Kawamura A, Andrews C, Miller J, Wu D, Tsao T, et al. Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect. J Immunol. 2015;195:2710-21 pubmed publisher
    A CD1d-binding glycolipid, α-Galactosylceramide (αGalCer), activates invariant NK T cells and acts as an adjuvant...
  47. Gschwandtner M, Kienzl P, Tajpara P, Schuster C, Stipek G, Buchberger M, et al. The Reticulum-Associated Protein RTN1A Specifically Identifies Human Dendritic Cells. J Invest Dermatol. 2018;138:1318-1327 pubmed publisher
    ..Here we show that the main isoform RTN1A is a marker for dendritic cells. In the skin, HLA-DR+CD1ahighCD207+CD11cweak Langerhans cells were the only cells in the epidermis, and HLA-..
  48. Sharma M, Zhang X, Zhang S, Niu L, Ho S, Chen A, et al. Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants. Sci Rep. 2017;7:2085 pubmed publisher
    ..Our results demonstrated that the expression of CD1a and CD1d proteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a]pyrene even ..
  49. Zeissig S, Peuker K, Iyer S, Gensollen T, Dougan S, Olszak T, et al. CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation. Proc Natl Acad Sci U S A. 2017;114:10449-10454 pubmed publisher
    Invariant natural killer T (iNKT) cells recognize lipid antigens presented by CD1d and play a central role in regulating immunity and inflammation in peripheral tissues...
  50. Moody D, Cotton R. Four pathways of CD1 antigen presentation to T cells. Curr Opin Immunol. 2017;46:127-133 pubmed publisher
    b>CD1a, CD1b, CD1c and CD1d proteins migrate through distinct subcellular compartments of antigen presenting cells and so can be considered to take four separate pathways leading to display of lipid antigens to T cell receptors...
  51. Conter V, Valsecchi M, Buldini B, Parasole R, Locatelli F, Colombini A, et al. Early T-cell precursor acute lymphoblastic leukaemia in children treated in AIEOP centres with AIEOP-BFM protocols: a retrospective analysis. Lancet Haematol. 2016;3:e80-6 pubmed publisher
    ..Early T-cell precursors were defined as being CD1a and CD8 negative, CD5 weak positive or negative, and positive for at least one of the following antigens: CD34, ..
  52. Ren J, Zhao Y, Liu M, Liu G, Chen F. Langerhans cell sarcoma arising from the root of tongue: a rare case. Int J Clin Exp Pathol. 2015;8:15312-5 pubmed
    ..Histological and immunophenotypic tests revealed that the malignant tumor cells were positive for S-100 protein, CD1a, and LCA, and partially positive for CD3ε...
  53. Zhang L, Reckling S, Dean G. Phenotypic and functional analysis of CD1a+ dendritic cells from cats chronically infected with feline immunodeficiency virus. Comp Immunol Microbiol Infect Dis. 2015;42:53-9 pubmed publisher
    ..We compared CD1a+ DC migration, surface phenotype, endocytosis, mixed leukocyte reaction (MLR) and regulatory T cell (Treg) ..
  54. Sugimoto K, Ueda S, Okada M, Takemura T. Membranoproliferative glomerulonephritis associated with Rosai-Dorfman disease. Clin Nephrol Case Stud. 2017;5:54-59 pubmed publisher
    ..Immunohistochemistry for S-100 protein, CD68, and lysozyme was positive within the interstitium. CD1a staining was absent. These findings were diagnostic for membranoproliferative glomerulonephritis...
  55. Pastores G, Hughes D. Lysosomal Storage Disorders and Malignancy. Diseases. 2017;5: pubmed publisher
    ..namely, ?-glucosylceramide 22:0 (?GL1-22) and glucosylsphingosine (LGL1), can be recognized by a distinct subset of CD1d-restricted human and murine type II natural killer T (NKT) cells...
  56. Roider E, Signer C, Fehrenbacher B, Metzler G, Schaller M, Kamarachev J, et al. Individualized Treatment Approaches for Langerhans Cell Histiocytosis. Br J Dermatol. 2017;: pubmed publisher
    ..Myeloid dendritic cells that express the same antigens (CD1a, CD207) as epidermal Langerhans cell seem to be the precursor cells for LCH [2]...
  57. Carrera Silva E, Nowak W, Tessone L, Olexen C, Ortiz Wilczyñski J, Estecho I, et al. CD207+CD1a+ cells circulate in pediatric patients with active Langerhans cell histiocytosis. Blood. 2017;130:1898-1902 pubmed publisher
    ..LCH) is a rare disease with an unknown etiology characterized by heterogeneous lesions containing CD207+CD1a+ cells that can arise in almost any tissue and cause significant morbidity and mortality...
  58. Ye Z, Liu J, Zheng J, Zhang J, Huang R. L-selectin Promotes the Maturation of Dendritic Cells via Up-regulation the Expression of TLR4 in vitro. Ann Clin Lab Sci. 2017;47:389-394 pubmed
    ..The expression of mature antigens CD1a, CD80, CD83, and CD86 were investigated by flow cytometric analysis (FACS)...
  59. Piris M, Aguirregoicoa E, Montes Moreno S, Celeiro Muñoz C. Castleman Disease and Rosai-Dorfman Disease. Semin Diagn Pathol. 2018;35:44-53 pubmed publisher
    ..Disease is a histiocytic proliferative disorder diagnosed by the presence of tissue infiltration by S100-positive CD1a-negative histiocytes and plasma cell aggregates, often with Russell bodies...
  60. Melian A, Beckman E, Porcelli S, Brenner M. Antigen presentation by CD1 and MHC-encoded class I-like molecules. Curr Opin Immunol. 1996;8:82-8 pubmed
    ..Recent studies have indicated that CD1 molecules mediate a novel system of antigen presentation and that MHC-encoded class I-like molecules can present unique subsets of intracellularly derived peptides. ..
  61. Rincón Arévalo H, Villa Pulgarín J, Tabares J, Rojas M, Vásquez G, Ramírez Pineda J, et al. Interleukin-10 production and T cell-suppressive capacity in B cell subsets from atherosclerotic apoE -/- mice. Immunol Res. 2017;65:995-1008 pubmed publisher
    ..Atherosclerotic mice had increased frequency of IL-10+ B cells, which presented high CD1d, CD19, and IgM, but variable CD5, CD21, and CD23 expression...
  62. Liu J, Gallo R, Duffy C, Brutkiewicz R. A VP22-Null HSV-1 Is Impaired in Inhibiting CD1d-Mediated Antigen Presentation. Viral Immunol. 2016;29:409-16 pubmed publisher
    b>CD1d-restricted T (natural killer T [NKT]) cells are important for controlling a herpes simplex virus (HSV) infection. One of the mechanisms of immune evasion by HSV is to downregulate CD1d-mediated activation of NKT cells...
  63. Zeng J, Shahbazi M, Wu C, Toh H, Wang S. Enhancing immunostimulatory function of human embryonic stem cell-derived dendritic cells by CD1d overexpression. J Immunol. 2012;188:4297-304 pubmed publisher
    ..In this study, we investigated whether CD1d upregulation in hESC-DCs may exploit invariant NKT (iNKT) cell adjuvant activity and boost antitumor immunity...
  64. Sanderson J, Waldburger Hauri K, Garzón D, Matulis G, Mansour S, Pumphrey N, et al. Natural variations at position 93 of the invariant V?24-J?18 ? chain of human iNKT-cell TCRs strongly impact on CD1d binding. Eur J Immunol. 2012;42:248-55 pubmed publisher
    Human invariant natural killer T (NKT) cell TCRs bind to CD1d via an "invariant" V?24-J?18 chain (iNKT?) paired to semi-invariant V?11 chains (iNKT?)...
  65. Wang K, Tao L, Su J, Zhang Y, Zou B, Wang Y, et al. TLR4 supports the expansion of FasL+CD5+CD1dhi regulatory B cells, which decreases in contact hypersensitivity. Mol Immunol. 2017;87:188-199 pubmed publisher
    ..cells termed as "regulatory B cells" (Bregs) can suppress the ongoing immune responses and a splenic CD5+CD1dhi Breg subset identified earlier was shown to exert its regulatory functions through secretion of IL-10...
  66. Hong J, Fang J, Lan R, Tan Q, Tian Y, Zhang M, et al. TLR9 mediated regulatory B10 cell amplification following sub-total body irradiation: Implications in attenuating EAE. Mol Immunol. 2017;83:52-61 pubmed publisher
    ..Prolonged ODN1826 stimulation (48h) induced additional spleen CD19hiCD5+CD1dhi B cells to express IL-10...
  67. Lorillon G, Tazi A. How I manage pulmonary Langerhans cell histiocytosis. Eur Respir Rev. 2017;26: pubmed publisher
    ..of unknown aetiology that is characterised by the infiltration and destruction of the wall of distal bronchioles by CD1a+ Langerhans-like cells. In adults, PLCH is frequently isolated and affects young smokers of both sexes...
  68. Kohlgruber A, Donado C, LaMarche N, Brenner M, Brennan P. Activation strategies for invariant natural killer T cells. Immunogenetics. 2016;68:649-63 pubmed publisher
    ..Specific microbial lipids and mammalian self lipids displayed by the antigen-presenting molecule CD1d can activate iNKT cells through their semi-invariant ?? T cell receptors (TCRs)...
  69. Yanagisawa K, Yue S, van der Vliet H, Wang R, Alatrakchi N, Golden Mason L, et al. Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C. J Viral Hepat. 2013;20:556-65 pubmed publisher
    Hepatic CD1d-restricted and natural killer T-cell populations are heterogeneous. Classical 'type 1' ?-galactosylceramide-reactive CD1d-restricted T cells express 'invariant' TCR? ('iNKT')...
  70. Garzón D, Anselmi C, Bond P, Faraldo Gómez J. Dynamics of the antigen-binding grooves in CD1 proteins: reversible hydrophobic collapse in the lipid-free state. J Biol Chem. 2013;288:19528-36 pubmed publisher
    ..By contrast, we show that the binding cavity of CD1a is largely preserved in the unliganded state because of persistent electrostatic interactions that keep the portal ?..
  71. Anastasiadis A, Kotsianidis I, Papadopoulos V, Spanoudakis E, Margaritis D, Christoforidou A, et al. CD1d expression as a prognostic marker for chronic lymphocytic leukemia. Leuk Lymphoma. 2014;55:320-5 pubmed publisher
    We analyzed the expression of CD1d, an antigen-presenting molecule, on peripheral blood leukemic cells of cases of chronic lymphocytic leukemia (CLL) by flow cytometry...
  72. Bosma A, Abdel Gadir A, Isenberg D, Jury E, Mauri C. Lipid-antigen presentation by CD1d(+) B cells is essential for the maintenance of invariant natural killer T cells. Immunity. 2012;36:477-90 pubmed publisher
    B cells perform many immunological functions, including presenting lipid antigen to CD1d-restricted invariant natural killer T (iNKT) cells, known to contribute to maintaining tolerance in autoimmunity...
  73. Hossain M, Hanashima S, Nomura T, Lethu S, Tsuchikawa H, Murata M, et al. Synthesis and Th1-immunostimulatory activity of ?-galactosylceramide analogues bearing a halogen-containing or selenium-containing acyl chain. Bioorg Med Chem. 2016;24:3687-95 pubmed publisher
    A novel series of CD1d ligand ?-galactosylceramides (?-GalCers) were synthesized by incorporation of the heavy atoms Br and Se in the acyl chain backbone of ?-galactosyl-N-cerotoylphytosphingosine...
  74. Radzikowska E. Pulmonary Langerhans' cell histiocytosis in adults. Adv Respir Med. 2017;85:277-289 pubmed publisher
    ..diagnosis requires the finding of characteristic lesions in histological examination and demonstration of antigen CD1a or CD207 presenting cells in immunohistochemistry...
  75. Benlagha K, Kyin T, Beavis A, Teyton L, Bendelac A. A thymic precursor to the NK T cell lineage. Science. 2002;296:553-5 pubmed
    b>CD1d-restricted autoreactive natural killer (NK1.1+) T cells function as regulatory cells in various disease conditions. Using improved tetramer tracking methodology, we identified a NK1...
  76. Bozna B, Polzella P, Rankl C, Zhu R, Salio M, Shepherd D, et al. Binding strength and dynamics of invariant natural killer cell T cell receptor/CD1d-glycosphingolipid interaction on living cells by single molecule force spectroscopy. J Biol Chem. 2011;286:15973-9 pubmed publisher
    ..that play an important role in regulating immunity to infection and tumors by recognizing endogenous and exogenous CD1d-bound lipid molecules...