Gene Symbol: CD1C
Description: CD1c molecule
Alias: BDCA1, CD1, CD1A, T-cell surface glycoprotein CD1c, CD1C antigen, c polypeptide, cortical thymocyte antigen CD1C, differentiation antigen CD1-alpha-3
Species: human
Products:     CD1C

Top Publications

  1. Sugita M, Grant E, van Donselaar E, Hsu V, Rogers R, Peters P, et al. Separate pathways for antigen presentation by CD1 molecules. Immunity. 1999;11:743-52 pubmed
    ..We show that CD1b traffics deeply into late endosomal compartments, while CD1a is excluded from these compartments and instead traffics independently in the recycling pathway of the early ..
  2. Briken V, Jackman R, Watts G, Rogers R, Porcelli S. Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens. J Exp Med. 2000;192:281-8 pubmed
    CD1b and CD1c are antigen-presenting molecules that mediate recognition of bacterial lipids by T cells, but it is currently not known whether these two molecules are redundant or are specialized to perform different immunological ..
  3. Roura Mir C, Catalfamo M, Cheng T, Marqusee E, Besra G, Jaraquemada D, et al. CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis. J Immunol. 2005;174:3773-80 pubmed
    ..possible roles of CD1 in human autoimmune diseases in vivo are not known, especially for the group 1 CD1 isoforms (CD1a, CD1b, and CD1c)...
  4. Scharf L, Li N, Hawk A, Garzón D, Zhang T, Fox L, et al. The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity. 2010;33:853-62 pubmed publisher
    CD1 molecules function to present lipid-based antigens to T cells. Here we present the crystal structure of CD1c at 2...
  5. Allan L, Stax A, Zheng D, Chung B, Kozak F, Tan R, et al. CD1d and CD1c expression in human B cells is regulated by activation and retinoic acid receptor signaling. J Immunol. 2011;186:5261-72 pubmed publisher
    ..b>CD1c expression and function also decreased following activation by CD40L alone, whereas activation via the BCR ..
  6. Kassianos A, Hardy M, Ju X, Vijayan D, Ding Y, Vulink A, et al. Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli. Eur J Immunol. 2012;42:1512-22 pubmed publisher
    Human blood myeloid DCs can be subdivided into CD1c (BDCA-1)(+) and CD141 (BDCA-3)(+) subsets that display unique gene expression profiles, suggesting specialized functions...
  7. Li D, Hong A, Lu Q, Gao G, Jin B, Screaton G, et al. A novel role of CD1c in regulating CD1d-mediated NKT cell recognition by competitive binding to Ig-like transcript 4. Int Immunol. 2012;24:729-37 pubmed publisher
    ..In this study, we show that CD1c can also interact specifically with ILT4 with a higher affinity than that of CD1d...
  8. Moody D, Ulrichs T, Muhlecker W, Young D, Gurcha S, Grant E, et al. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature. 2000;404:884-8 pubmed
    ..Here we show that the T-cell antigen receptor and the CD1c protein mediate recognition of an evolutionarily conserved family of isoprenoid glycolipids whose members include ..
  9. Briken V, Moody D, Porcelli S. Diversification of CD1 proteins: sampling the lipid content of different cellular compartments. Semin Immunol. 2000;12:517-25 pubmed
    ..CD1b and CD1d are found in acidic, late endocytic compartments, whereas CD1a and CD1c molecules accumulate at the plasma membrane and in early endosomes...

More Information

Publications117 found, 100 shown here

  1. Leslie D, Vincent M, Spada F, Das H, Sugita M, Morita C, et al. CD1-mediated gamma/delta T cell maturation of dendritic cells. J Exp Med. 2002;196:1575-84 pubmed
    ..As Vdelta1+ gamma/delta T cells are the main tissue subset of gamma/delta T cells and they are known to recognize CD1c in the absence of specific foreign antigen recognition, we examined the possible interaction of these T cells with ..
  2. Brigl M, Brenner M. CD1: antigen presentation and T cell function. Annu Rev Immunol. 2004;22:817-90 pubmed
    ..range of diseases in which CD1-restricted T cells play important roles and reveal differences in the role of CD1a, CD1b, and CD1c in contrast to CD1d...
  3. Vincent M, Xiong X, Grant E, Peng W, Brenner M. CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens. J Immunol. 2005;175:6344-51 pubmed
    ..In this study, we have identified CD1a-, CD1b-, and CD1c-restricted T cells from normal human donors that induce cytolysis and secrete copious IFN-gamma in response to self-..
  4. Van Rhijn I, Young D, de Jong A, Vazquez J, Cheng T, Talekar R, et al. CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J Exp Med. 2009;206:1409-22 pubmed publisher
    The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells...
  5. Haig N, Guan Z, Li D, McMichael A, Raetz C, Xu X. Identification of self-lipids presented by CD1c and CD1d proteins. J Biol Chem. 2011;286:37692-701 pubmed publisher
    ..Here, we employed mass spectrometry to analyze the lipid content of highly purified CD1c and CD1d protein samples. We report the identification of 11 novel self-lipids presented by CD1c and nine by CD1d...
  6. Gupta M, Kolli D, Garofalo R. Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection. Respir Res. 2013;14:71 pubmed publisher
    ..Findings of differential expression of PD-L1 and IL-10 by infected mDCs, suggests possible mechanisms by which RSV is able to impair adaptive immune responses. ..
  7. Sugita M, van der Wel N, Rogers R, Peters P, Brenner M. CD1c molecules broadly survey the endocytic system. Proc Natl Acad Sci U S A. 2000;97:8445-50 pubmed
    ..In contrast, CD1a and CD1b molecules mediate the presentation of lipid and glycolipid antigens and differentially sample early ..
  8. Vincent M, Leslie D, Gumperz J, Xiong X, Grant E, Brenner M. CD1-dependent dendritic cell instruction. Nat Immunol. 2002;3:1163-8 pubmed
    ..We show here that self-reactive CD1-restricted T cells can promote DC maturation by recognizing CD1 in the absence of foreign antigens...
  9. Matsunaga I, Bhatt A, Young D, Cheng T, Eyles S, Besra G, et al. Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. J Exp Med. 2004;200:1559-69 pubmed
    b>CD1c-mediated T cells are activated by a mycobacterial phospholipid antigen whose carbohydrate structure precisely corresponds to mammalian mannosyl beta-1-phosphodolichol (MPD), but contains an unusual lipid moiety...
  10. Kallert S, Zenk S, Walther P, Grieshober M, Weil T, Stenger S. Liposomal delivery of lipoarabinomannan triggers Mycobacterium tuberculosis specific T-cells. Tuberculosis (Edinb). 2015;95:452-62 pubmed publisher
    ..for the activation of LAM-specific T-cells is the efficient uptake and transport of the glycolipid antigen to the CD1 antigen presenting machinery...
  11. Leonhardt I, Spielberg S, Weber M, Albrecht Eckardt D, Bläss M, Claus R, et al. The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. MBio. 2015;6:e00143 pubmed publisher
    ..Several markers important for maturation and antigen presentation like CD1a, CD83, CD86, and CD80 were significantly reduced in the presence of farnesol...
  12. Öğrenci A, Batcik O, Ekşi M, Koban O. Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it?. Childs Nerv Syst. 2016;32:1513-6 pubmed publisher
    ..b>CD1a was positive yet S100 was negative. Final diagnosis was eosinophilic granuloma...
  13. Sezer E, Oztürk Durmaz E, Cetin E, Sahin S. Meyerson Phenomenon as a Component of Melanoma in situ. Acta Dermatovenerol Croat. 2016;24:81-2 pubmed
    ..Immunohistochemical staining with the Langerhans cell marker, CD1a, revealed an increased cell population in the perilesional, erythematous halo (Figure 1, d)...
  14. Saad A, Diken Z, Kechichian T, Clark S, Olson G, Saade G, et al. Pravastatin Effects on Placental Prosurvival Molecular Pathways in a Mouse Model of Preeclampsia. Reprod Sci. 2016;23:1593-1599 pubmed
    ..Pregnant CD1 mice at day 8 of gestation (length of gestation 19 days) were randomly allocated to injection via tail vein with ..
  15. Ascione R, Rowlinson J, Avolio E, Katare R, Meloni M, Spencer H, et al. Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction. Stem Cell Res Ther. 2015;6:53 pubmed publisher
    ..Cells groups were also intramyocardially injected in an in vivo model of MI (8-week-old immune deficient CD1-FOXN1(nu/nu) mice). Echocardiography and hemodynamic measurements were performed before and at 14 days post-MI...
  16. Quigley H, Pitha I, Welsbie D, Nguyen C, Steinhart M, Nguyen T, et al. Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS ONE. 2015;10:e0141137 pubmed publisher
    ..We produced IOP increase in CD1 mice and performed unilateral optic nerve crush...
  17. Grobost V, Khouatra C, Lazor R, Cordier J, Cottin V. Effectiveness of cladribine therapy in patients with pulmonary Langerhans cell histiocytosis. Orphanet J Rare Dis. 2014;9:191 pubmed publisher
    Pulmonary Langerhans cell histiocytosis (PLCH) is a rare disorder characterised by granulomatous proliferation of CD1a-positive histiocytes forming granulomas within lung parenchyma, in strong association with tobacco smoking, and which ..
  18. Yang P, Wu J, Miao L, Manaenko A, Matei N, Zhang Y, et al. Platelet-Derived Growth Factor Receptor-? Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice. Crit Care Med. 2016;44:e390-402 pubmed publisher
    ..Controlled in vivo laboratory study. Animal research laboratory. One hundred and fifty six eight-week-old male CD1 mice. Brain injury was induced by autologous arterial blood or plasmin injection into mouse brains...
  19. Renaud L, Harris L, Mani S, Kasiganesan H, CHOU J, Baicu C, et al. HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis. Circ Heart Fail. 2015;8:1094-104 pubmed publisher
    ..Transverse aortic constriction (TAC) was performed in CD1 mice to induce pressure overload hypertrophy...
  20. Zhu J, Xu Y, Rashedi A, Pavone M, Kim J, Woodruff T, et al. Human fallopian tube epithelium co-culture with murine ovarian follicles reveals crosstalk in the reproductive cycle. Mol Hum Reprod. 2016;22:756-767 pubmed
    ..6) who had not undergone exogenous hormonal treatment for at least 3 months prior to surgery. CD1 female mice were used for ovarian follicle isolation...
  21. Gunji Niitsu Y, Kumasaka T, Kitamura S, Hoshika Y, Hayashi T, Tokuda H, et al. Benign clear cell "sugar" tumor of the lung in a patient with Birt-Hogg-Dubé syndrome: a case report. BMC Med Genet. 2016;17:85 pubmed
    ..revealed that these tumor cells were positive for microphthalmia-transcription factor, S100, and CD1a but negative for HMB45, indicating that the tumor was a CCST...
  22. Garrido A, Cruces J, Ceprián N, Hernandez Sanchez C, de la Fuente M. Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. A longitudinal study. Brain Behav Immun. 2018;69:440-455 pubmed publisher
    ..ICR-CD1 female TH-HZ and wild type (WT) mice were used in a longitudinal study...
  23. Venerosi A, Tait S, Stecca L, Chiarotti F, De Felice A, Cometa M, et al. Effects of maternal chlorpyrifos diet on social investigation and brain neuroendocrine markers in the offspring - a mouse study. Environ Health. 2015;14:32 pubmed publisher
    ..Pregnant CD1 outbred mice were fed from gestational day 15 to lactation day 14 with either a CPF-added (equivalent to 6 mg/kg/bw/..
  24. Gheorghe A, Pérez de Heredia F, Hunsche C, Redondo N, Díaz L, Hernández O, et al. Oxidative stress and immunosenescence in spleen of obese mice can be reversed by 2-hydroxyoleic acid. Exp Physiol. 2017;102:533-544 pubmed publisher
    ..Female ICR/CD1 mice (8 weeks old, n = 24) received an obesogenic diet (22% fat for 4 weeks and 60% fat for 14 weeks)..
  25. Van Kaer L, Wu L, Joyce S. Mechanisms and Consequences of Antigen Presentation by CD1. Trends Immunol. 2016;37:738-754 pubmed publisher
    The CD1 proteins are a family of non-polymorphic and MHC class I-related molecules that present lipid antigens to subsets of T lymphocytes with innate- or adaptive-like immune functions...
  26. Joffre C, Gregoire S, De Smedt V, Acar N, Bretillon L, Nadjar A, et al. Modulation of brain PUFA content in different experimental models of mice. Prostaglandins Leukot Essent Fatty Acids. 2016;114:1-10 pubmed publisher
    ..available in the literature we here compared the brain fatty acid composition in various mice models (C57BL/6J, CD1, Fat-1, SAMP8 mice) fed with different n-3 PUFA diets (deficient, balanced, enriched) in adults and aged animals...
  27. Rabasa C, Pastor Ciurana J, Delgado Morales R, Gómez Román A, Carrasco J, Gagliano H, et al. Evidence against a critical role of CB1 receptors in adaptation of the hypothalamic-pituitary-adrenal axis and other consequences of daily repeated stress. Eur Neuropsychopharmacol. 2015;25:1248-59 pubmed publisher
    ..of CB1R in the expression of HPA adaptation to another similar stressor (restraint) was confirmed in wild-type CD1 mice by the lack of effect of the CB1R antagonist AM251 just before the last exposure to stress...
  28. Kim S, Lee M, Shin H, Lee J, Suh Y. Coexistence of intracranial Langerhans cell histiocytosis and Erdheim-Chester disease in a pediatric patient: a case report. Childs Nerv Syst. 2016;32:893-6 pubmed publisher
    ..Immunohistochemically, the LCH contained CD1a-positive Langerhans cells and the ECD had CD1a-negative, CD68-positive foamy histiocytes...
  29. Chen M, Kan L, Ledford B, He J. Tattooing Various Combinations of Ears, Tail, and Toes to Identify Mice Reliably and Permanently. J Am Assoc Lab Anim Sci. 2016;55:189-98 pubmed
    ..Four groups (neonatal and adult C57BL/6J [black] and CD1 [white] mice) were used...
  30. Niu L, Li Y, Wang P, Zhang W, Wang C, Cai W, et al. Altitude-scale variation in nitrogen-removal bacterial communities from municipal wastewater treatment plants distributed along a 3600-m altitudinal gradient in China. Sci Total Environ. 2016;559:38-44 pubmed publisher
    ..and nitrite-reducing bacteria containing the copper-containing nitrite reductase gene (nirK-NRB) and the cytochrome cd1-containing nitrite reductase gene (nirS-NRB) were investigated in 18 municipal WWTPs distributed along a 3660-masl ..
  31. Lundgren S, Warfvinge C, Elebro J, Heby M, Nodin B, Krzyzanowska A, et al. The Prognostic Impact of NK/NKT Cell Density in Periampullary Adenocarcinoma Differs by Morphological Type and Adjuvant Treatment. PLoS ONE. 2016;11:e0156497 pubmed publisher
    ..Immune cell-specific expression of CD56, CD3, CD68 and CD1a was analysed by immunohistochemistry on tissue microarrays with tumours from 175 consecutive cases of periampullary ..
  32. Huang Y, Zhang W, Cai H, Li T, Li J, Han B, et al. [CD200/CD200R Expression Levels and Its Significance after Allogeneic Hematopoietic Stem Cell Transplantation]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:815-20 pubmed publisher
    ..Firstly, the expression levels of CD200 and CD200R on CD19+ cell, CD3+ cell and dendritic cell (CD19- CD14- CD1c+) surfaces in each group were detected by using flow cytometry, so as to determine whether there were expression ..
  33. Zöllner J, Howe L, Edey L, O Dea K, Takata M, Gordon F, et al. The response of the innate immune and cardiovascular systems to LPS in pregnant and nonpregnant mice. Biol Reprod. 2017;97:258-272 pubmed publisher
    ..Female CD1 mice had radiotelemetry probes implanted and were time mated...
  34. Li Y, Li S, Chen I. Expression of the GM2 activator protein in mouse testis. Reprod Biol. 2017;17:376-379 pubmed publisher
    ..Over the years, the GM2-AP has also been shown to be involved in kidney vesicular transport, lipid presentation by CD1 molecule to T-cells, and interaction of human sperm with zona pellucida...
  35. Moura A, Guedes F, Rivitti Machado M, Sotto M. Inate immunity in rosacea. Langerhans cells, plasmacytoid dentritic cells, Toll-like receptors and inducible oxide nitric synthase (iNOS) expression in skin specimens: case-control study. Arch Dermatol Res. 2018;310:139-146 pubmed publisher
    ..Immunohistochemical demonstration of Langerhans cells (anti-CD1a antibody), PDC (anti-CD 123 antibody), TLR2, TLR4 and iNOS was performed in skin samples and compared with normal ..
  36. Zahid H, Miah L, Lau A, Brochard L, Hati D, Bui T, et al. Zinc-induced oligomerization of zinc α2 glycoprotein reveals multiple fatty acid-binding sites. Biochem J. 2016;473:43-54 pubmed publisher
    ..for DAUDA and C16-BODIPY, similar to the multiple lipid binding seen in the structurally related immune protein CD1c. In addition, because high concentrations of zinc occur in the pancreas, the perturbation of these multiple lipid-..
  37. Leone D, Kozakowski N, Kornauth C, Waidacher T, Neudert B, Loeffler A, et al. The Phenotypic Characterization of the Human Renal Mononuclear Phagocytes Reveal a Co-Ordinated Response to Injury. PLoS ONE. 2016;11:e0151674 pubmed publisher
    ..These include: plasmacytoid DC (CD303+) and both types of conventional DC-cDC1 (CD141+ cells) and CD2 (CD1c+ cells); classical, non-classical and intermediate monocytes; and macrophages including a novel population of CD141+..
  38. Kosten I, Spiekstra S, de Gruijl T, Gibbs S. MUTZ-3 Langerhans cell maturation and CXCL12 independent migration in reconstructed human gingiva. ALTEX. 2016;33:423-434 pubmed publisher
    ..of GE-LC resulted in an increase in MUTZ-3 LC and CD83 mRNA in the hydrogel but did not result in an increase in CD1a+ cells in the collagen hydrogel (as was observed for SE-LC...
  39. Vogel Ciernia A, Pride M, Durbin Johnson B, Noronha A, Chang A, Yasui D, et al. Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering. Hum Mol Genet. 2017;26:1839-1854 pubmed publisher
    ..Cross-fostering to CD1 dams accelerated several developmental milestones independent of genotype, and induced earlier onset of weight gain ..
  40. Vijayan V, Gupta S. Role of osteocytes in mediating bone mineralization during hyperhomocysteinemia. J Endocrinol. 2017;233:243-255 pubmed publisher
    ..b>CD1 mice administered with homocysteine (5 mg/100 g body weight, i.p...
  41. Silva Dos Santos D, Brasil G, Ramos I, Mesquita F, Kasai Brunswick T, Christie M, et al. Embryonic stem cell-derived cardiomyocytes for the treatment of doxorubicin-induced cardiomyopathy. Stem Cell Res Ther. 2018;9:30 pubmed publisher
    ..Total conditioned medium (TCM) from the CM-mESCs was collected for proteomic analysis. To establish DIC in CD1 mice, Dox (7.5 mg/kg) was administered once a week for 3 weeks, resulting in a cumulative Dox dose of 22.5 mg/kg...
  42. Liu G, Li S, Yuan H, Hao M, Wurihan -, Yun Z, et al. Effect of sodium alginate on mouse ovary vitrification. Theriogenology. 2018;113:78-84 pubmed publisher
    ..The ovaries obtained from 6-weeks old CD1 were assigned into six groups from A to F. Group A without treatment was used as the normal control...
  43. Lewis A, Mineur Y, Smith P, Cahuzac E, Picciotto M. Modulation of aggressive behavior in mice by nicotinic receptor subtypes. Biochem Pharmacol. 2015;97:488-497 pubmed publisher
    ..serenic effects of acute nicotine administration in three distinct mouse strains: C57BL/6, BALB/c, and CD1. While acute nicotine administration (0...
  44. Katen A, Stanger S, Anderson A, Nixon B, Roman S. Chronic acrylamide exposure in male mice induces DNA damage to spermatozoa; Potential for amelioration by resveratrol. Reprod Toxicol. 2016;63:1-12 pubmed publisher
    ..Acrylamide was administered to male CD1 mice for three or six months at a dose of 0.18mg/kg bodyweight/day...
  45. Bakdash G, Buschow S, Gorris M, Halilovic A, Hato S, Sköld A, et al. Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines. Cancer Res. 2016;76:4332-46 pubmed publisher
    ..Here we report the identification of a novel BDCA1(+)CD14(+) population of immunosuppressive myeloid cells that are expanded in melanoma patients and are present in ..
  46. Bao H, Yang X, Zhuang Y, Huang Y, Wang T, Zhang M, et al. The effects of poloxamer 188 on the autophagy induced by traumatic brain injury. Neurosci Lett. 2016;634:7-12 pubmed publisher
    ..b>CD1 mice were randomized into saline and P188-treatment groups (both undergoing intravenous injection of 4mg/ml, 100?l ..
  47. Khan F, Pandian V, Ramraj S, Natarajan M, Aravindan S, Herman T, et al. Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes. BMC Cancer. 2015;15:514 pubmed publisher
    ..genetic alterations in chromosomes 1, 7, 8, and 22, corresponding to a gain in the copy numbers of LOC100288142, CD1C, CFHR3, FOXP2, MDFIC, RALYL, CSMD3, SAMD12-AS1, and MAL2, and a loss in ADAM5, LOC400927, APOBEC3B, RPL3, MGAT3, ..
  48. Ren J, Zhao Y, Liu M, Liu G, Chen F. Langerhans cell sarcoma arising from the root of tongue: a rare case. Int J Clin Exp Pathol. 2015;8:15312-5 pubmed
    ..Histological and immunophenotypic tests revealed that the malignant tumor cells were positive for S-100 protein, CD1a, and LCA, and partially positive for CD3ε...
  49. Yang P, Manaenko A, Xu F, Miao L, Wang G, Hu X, et al. Role of PDGF-D and PDGFR-β in neuroinflammation in experimental ICH mice model. Exp Neurol. 2016;283:157-64 pubmed publisher
    ..A blood injection model of ICH was used in eight-week old male CD1 mice (weight 30g). Some mice received an injection of plasmin or PDGF-D...
  50. Singh J, Kumar A, Sharma A. Antianxiety activity guided isolation and characterization of bergenin from Caesalpinia digyna Rottler roots. J Ethnopharmacol. 2017;195:182-187 pubmed publisher
    ..1-F4.3) and a compound CD2. CD1 and CD2 were characterized using standard spectral techniques. Three fractions (F4.1-F4...
  51. Sharma M, Zhang X, Zhang S, Niu L, Ho S, Chen A, et al. Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants. Sci Rep. 2017;7:2085 pubmed publisher
    ..Our results demonstrated that the expression of CD1a and CD1d proteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a]..
  52. Moody D, Cotton R. Four pathways of CD1 antigen presentation to T cells. Curr Opin Immunol. 2017;46:127-133 pubmed publisher
    b>CD1a, CD1b, CD1c and CD1d proteins migrate through distinct subcellular compartments of antigen presenting cells and so can be considered to take four separate pathways leading to display of lipid antigens to T cell receptors...
  53. Paradis F, Hales B. The Effects of Class-Specific Histone Deacetylase Inhibitors on the Development of Limbs During Organogenesis. Toxicol Sci. 2015;148:220-8 pubmed publisher
    ..Timed-pregnant COL2A1-ECFP, COL10A1-mCherry, and COL1A1-YFP CD1 reporter mice were euthanized on gestation day 12; embryonic forelimbs were excised and cultured in vitro for 1, 3, ..
  54. Zhang L, Reckling S, Dean G. Phenotypic and functional analysis of CD1a+ dendritic cells from cats chronically infected with feline immunodeficiency virus. Comp Immunol Microbiol Infect Dis. 2015;42:53-9 pubmed publisher
    ..We compared CD1a+ DC migration, surface phenotype, endocytosis, mixed leukocyte reaction (MLR) and regulatory T cell (Treg) ..
  55. Conter V, Valsecchi M, Buldini B, Parasole R, Locatelli F, Colombini A, et al. Early T-cell precursor acute lymphoblastic leukaemia in children treated in AIEOP centres with AIEOP-BFM protocols: a retrospective analysis. Lancet Haematol. 2016;3:e80-6 pubmed publisher
    ..Early T-cell precursors were defined as being CD1a and CD8 negative, CD5 weak positive or negative, and positive for at least one of the following antigens: CD34, ..
  56. Andersson A, Holst P. Increased T cell breadth and antibody response elicited in prime-boost regimen by viral vector encoded homologous SIV Gag/Env in outbred CD1 mice. J Transl Med. 2016;14:343 pubmed publisher
    ..Outbred CD1 mice were immunized with either heterologous (SIVmac239 and HIV-1 clade B consensus) or homologous (SIVmac239) gag ..
  57. Mardi K, Thakur R, Negi L. Intradural Eosinophilic Granuloma Invading Skull: Case Report and Review of the Literature. Asian J Neurosurg. 2017;12:698-700 pubmed publisher
    ..Right parietal extended craniotomy was done with the excision of mass from the dura. Histopathological features of mass were characteristic of eosinophilic granuloma which was confirmed by positive immunohistochemical staining for CD1a.
  58. Gschwandtner M, Kienzl P, Tajpara P, Schuster C, Stipek G, Buchberger M, et al. The Reticulum-Associated Protein RTN1A Specifically Identifies Human Dendritic Cells. J Invest Dermatol. 2018;138:1318-1327 pubmed publisher
    ..Here we show that the main isoform RTN1A is a marker for dendritic cells. In the skin, HLA-DR+CD1ahighCD207+CD11cweak Langerhans cells were the only cells in the epidermis, and HLA-..
  59. Van Rhijn I, Moody D. Donor Unrestricted T Cells: A Shared Human T Cell Response. J Immunol. 2015;195:1927-32 pubmed publisher
    ..However, other T cells can be considered "donor unrestricted" because their targets, CD1a, CD1b, CD1c, CD1d, or MR1, are expressed in a similar form among all humans...
  60. Seshadri C, Lin L, Scriba T, Peterson G, Freidrich D, Frahm N, et al. T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents. J Immunol. 2015;195:4595-603 pubmed publisher
    ..T cells recognize cell wall lipids bound to CD1 molecules, but effector functions of CD1-reactive T cells have not been systematically assessed in M...
  61. Gudasheva T, Deeva O, Mokrov G, Yarkov S, Yarkova M, Seredenin S. The first dipeptide ligand of translocator protein: Design and anxiolytic activity. Dokl Biochem Biophys. 2015;464:290-3 pubmed publisher
    ..This compound exhibited anxiolytic activity in BALB/cAnN mice in the "open-field" test and in outbred CD1 mice in the "elevated plus maze" test. The stereoselectivity of the anxiolytic effect of GD-23 is demonstrated...
  62. Borhis G, Burelout C, Chaoul N, Smith N, Goujard C, Meyer L, et al. Plasmacytoid dendritic cells and myeloid cells differently contribute to B-cell-activating factor belonging to the tumor necrosis factor superfamily overexpression during primary HIV infection. AIDS. 2016;30:365-76 pubmed publisher
    ..monocytes in healthy donors, the frequency of mBAFF cells significantly increased among nonclassical monocytes and CD1c dendritic cells but decreased among pDC in PHI patients...
  63. Kaneko H, Kikuchi K, Noguchi J. Growth and fertilization of porcine fetal oocytes grafted under the renal capsules of nude mice. Theriogenology. 2016;86:1740-8 pubmed publisher
    ..fetuses at 55, 70, and 90 days postartificial insemination (dpi) were grafted into ovariectomized nude mice (Crlj:CD1-Foxn1(nu); 55-, 70- and 90-dpi groups, respectively)...
  64. Wang Y, Shang S, Sun Q, Chen J, Du G, Nie H, et al. Increased infiltration of CD11 c+/CD123+ dendritic cell subsets and upregulation of TLR/IFN-α signaling participate in pathogenesis of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:459-467.e2 pubmed publisher
    ..DC1 [mDC1], CD141+mDC2, CD11c-CD123+plasmacytoid DC [pDC], and CD1a+CD207+Langerhans cells [LC]) were investigated via flow cytometry (FCM) and ..
  65. Gupta M, Kolli D, Molteni C, Casola A, Garofalo R. Paramyxovirus infection regulates T cell responses by BDCA-1+ and BDCA-3+ myeloid dendritic cells. PLoS ONE. 2014;9:e99227 pubmed publisher
    ..These results demonstrate a virus-specific and subset-specific effect of RSV and hMPV infection on mDC function, suggesting that these viruses may induce different adaptive immune responses. ..
  66. Kim M, Yu C, Theusch E, Naidoo D, Stevens K, Kuang Y, et al. SUGP1 is a novel regulator of cholesterol metabolism. Hum Mol Genet. 2016;25:3106-3116 pubmed
    ..Hepatic Sugp1 overexpression in CD1 male mice increased plasma cholesterol levels 20-50%...
  67. Moody D, Suliman S. CD1: From Molecules to Diseases. F1000Res. 2017;6:1909 pubmed publisher comprised of four types of antigen-presenting molecules, each with a distinct functional niche: CD1a, CD1b, CD1c, and CD1d...
  68. Teitell M, Holcombe H, Brossay L, Hagenbaugh A, Jackson M, Pond L, et al. Nonclassical behavior of the mouse CD1 class I-like molecule. J Immunol. 1997;158:2143-9 pubmed
    The mouse CD1 (mCD1) molecule is a class I-like molecule that is encoded outside of the MHC...
  69. Van Vré E, Bosmans J, Van Brussel I, Maris M, De Meyer G, Van Schil P, et al. Immunohistochemical characterisation of dendritic cells in human atherosclerotic lesions: possible pitfalls. Pathology. 2011;43:239-47 pubmed publisher
    ..Blood DC antigen (BDCA)-1, CD11c (mDCs), BDCA-2, CD123 (pDCs), langerin, fascin, S-100 (immature/mature DCs), and CD1a and CD83 (mature DCs) were investigated by immunohistochemistry of carotid arteries obtained by endarterectomy (EAS,..
  70. Lisovsky A, Zhang D, Sefton M. Effect of methacrylic acid beads on the sonic hedgehog signaling pathway and macrophage polarization in a subcutaneous injection mouse model. Biomaterials. 2016;98:203-14 pubmed publisher
    ..MAA beads also modulated the inflammatory cell infiltrate in CD1 mice: more neutrophils and more macrophages were noted with MAA relative to MM beads at days 1 and 7, respectively...
  71. Bagchi S, He Y, Zhang H, Cao L, Van Rhijn I, Moody D, et al. CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice. J Clin Invest. 2017;127:2339-2352 pubmed publisher
    A large proportion of human T cells are autoreactive to group 1 CD1 proteins, which include CD1a, CD1b, and CD1c. However, the physiological role of the CD1 proteins remains poorly defined...
  72. Jardim J, Gondak R, Miranda Galvis M, Pinto C, Kowalski L. Decreased peritumoral CD1a+ cells predicts worse prognosis in oral squamous cell carcinoma. Histopathology. 2017;: pubmed publisher
    ..This study aimed to evaluate the prognostic impact of intra and peritumoral dendritic cells in oral squamous cell carcinoma (OSCC) affecting tongue and floor of the mouth...
  73. Esser P, Martin S. Pathomechanisms of Contact Sensitization. Curr Allergy Asthma Rep. 2017;17:83 pubmed publisher
    ..of dendritic cells, the role of pre- and pro-haptens, antigen presentation and T cell activation via MHC and CD1 molecules, dendritic cell (DC) migration, and potential LC contribution as well as the different T cell subsets ..
  74. Rogers F, Hu R, Milstone L. Local delivery of gene-modifying triplex-forming molecules to the epidermis. J Invest Dermatol. 2013;133:685-691 pubmed publisher
    ..Successful in vivo genomic modification occurs in the epidermis and dermis in CD1 transgenic mice following either intraperitoneal or intradermal delivery of the PNA-Antp conjugate...
  75. Kelly H, Mandraju R, Coelho Dos Reis J, Tsuji M. Effects of HIV-1-induced CD1c and CD1d modulation and endogenous lipid presentation on CD1c-restricted T-cell activation. BMC Immunol. 2013;14:4 pubmed publisher
    ..In this study, we observed downregulation of both CD1c and CD1d expression through a Vpu-dependent and Nef-independent mechanism, and the concomitant HIV-1-induced ..
  76. Schulte B, Kers Rebel E, Bottino R, Piganelli J, Galama J, Engelse M, et al. Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected β cells. Clin Exp Immunol. 2016;184:293-307 pubmed publisher
    ..Here, we report on the responses of naturally occurring human myeloid BDCA1(+) DCs towards differentially stressed pancreatic β cells...
  77. Poiroux L, Paycha F, Polivka M, Ea H. Efficacy of zoledronic acid in Erdheim-Chester disease: A case report. Joint Bone Spine. 2016;83:573-5 pubmed publisher
    ..disease is rare form of non-Langerhans cell histiocytosis characterized by organ infiltration of CD68+ CD1a- histiocytes. Between 500 and 600 cases have been reported...
  78. Thurman A, Yousefieh N, Chandra N, Kimble T, Asin S, Rollenhagen C, et al. Comparison of Mucosal Markers of Human Immunodeficiency Virus Susceptibility in Healthy Premenopausal Versus Postmenopausal Women. AIDS Res Hum Retroviruses. 2017;33:807-819 pubmed publisher
    ..with decreased tight junction proteins and a higher density of mucosal immune T cells and lower levels of CD1a antigen-presenting cells, antimicrobial peptides, and inflammatory cytokines in the CVL (p values <.05)...
  79. Kim Y, Yie G, Kim N, Jeon I, Cho H, Seok J, et al. Pediatric intracerebral histiocytic sarcoma with rhabdoid features: Case report and literature review. Neuropathology. 2017;37:560-568 pubmed publisher
    ..and plump histiocytes with rhabdoid morphology, which were stained with S-100 protein, CD68 (KP1) and negative for CD1a. Histiocytic tumor was initially diagnosed...
  80. Li Y, Wang T, Zhang Z, Wang L. Aggressive Indeterminate Dendritic Cell Tumor Mimicking Scalp Angiosarcoma. Ann Dermatol. 2017;29:614-617 pubmed publisher
    Indeterminate dendritic cell tumor (IDCT) is a proliferation of CD1a+, S100+ and langerin- histiocytes with a generally benign course...
  81. Karatas H, Eun Jung J, Lo E, van Leyen K. Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models. Brain Res. 2018;1678:123-128 pubmed publisher
    ..ischemia/thrombolysis experiments, 10% FeCl3 was preferred so as to obtain reperfusion with tPA in CD1 mice. 4 h following ischemia either LB1 or DMSO and iv tPA was administered...
  82. Lopes D, de Almeida T, De Souza R, Ribeiro L, Page B, Fernandes J, et al. Susceptibility of dendritic cells from individuals with schistosomiasis to infection by Leishmania braziliensis. Mol Immunol. 2018;93:173-183 pubmed publisher
    ..braziliensis, and co-cultured with autologous lymphocytes. Expression of HLA-DR, CD1a, CD83, CD80, CD86, CD40, and the IL-10 receptor (IL-10R) on MoDCs as well as CD28, CD40L, CD25, and CTLA-4 on ..
  83. Zhang H, Meng J, Yu H. Trimethylamine N-oxide Supplementation Abolishes the Cardioprotective Effects of Voluntary Exercise in Mice Fed a Western Diet. Front Physiol. 2017;8:944 pubmed publisher
    ..Male CD1 mice fed a WD were assigned to sedentary, exercise or exercise with TMAO treatment for 8 weeks...
  84. Roy S, Ly D, Castro C, Li N, Hawk A, Altman J, et al. Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers. J Immunol. 2016;196:1933-42 pubmed publisher
    b>CD1c is abundantly expressed on human dendritic cells (DC) and B cells, where it binds and displays lipid Ags to T cells...
  85. Alculumbre S, Pattarini L. Purification of Human Dendritic Cell Subsets from Peripheral Blood. Methods Mol Biol. 2016;1423:153-67 pubmed publisher identified until now, from peripheral blood: plasmacytoid dendritic cells (pDCs), CD141(+) myeloid DCs, and CD1c(+) myeloid DCs. The method is based on the sequential depletion of non-DCs...
  86. Davis I, Quirk J, Morris L, Seddon L, Tai T, Whitty G, et al. A pilot study of peripheral blood BDCA-1 (CD1c) positive dendritic cells pulsed with NY-ESO-1 ISCOMATRIX™ adjuvant. Immunotherapy. 2017;9:249-259 pubmed publisher
    ..Pilot clinical trial of NY-ESO-1 (ESO) protein in ISCOMATRIX™ adjuvant pulsed onto peripheral blood dendritic cells (PBDC), to ascertain feasibility, evaluate toxicity and assess induction of ESO-specific immune responses...
  87. Iniguez S, Flores Ramirez F, Riggs L, Alipio J, Garcia Carachure I, Hernandez M, et al. Vicarious Social Defeat Stress Induces Depression-Related Outcomes in Female Mice. Biol Psychiatry. 2018;83:9-17 pubmed publisher
    ..C57BL/6 mice (8 weeks old, null parity) vicariously experienced the defeat bout of a male conspecific, by a male CD1 aggressor, for 10 consecutive days...
  88. Matsuyama K, Mizutani Y, Takahashi T, Shu E, Kanoh H, Miyazaki T, et al. Enhanced dendritic cells and regulatory T cells in the dermis of porokeratosis. Arch Dermatol Res. 2017;309:749-756 pubmed publisher
    ..We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor ?B ligand) in samples from ..
  89. Kwon H, Song P, Gu M. Occult Langerhans Cell Histiocytosis in Clear Cell Renal Cell Carcinoma. Int J Surg Pathol. 2017;:1066896917735171 pubmed publisher
    ..The mononuclear cells were Langerhans cell histiocytes with S-100 and CD1a immunoreactivity...
  90. Calandra C, Bustos A, Falcon F, Arakaki N. Erdheim-Chester disease: atypical presentation of a rare disease. BMJ Case Rep. 2017;2017: pubmed publisher
    ..biopsy revealed foamy histiocytes and isolated giant multinuclear cells immunoreactive to CD68 and negative to CD1a and S100. A diagnosis of Erdheim-Chester disease was made...
  91. Duyen H, Cerny D, Trung D, Pang J, Velumani S, Toh Y, et al. Skin dendritic cell and T cell activation associated with dengue shock syndrome. Sci Rep. 2017;7:14224 pubmed publisher
    ..analyzed cell subsets by flow cytometry, and soluble mediators and antibodies by ELISA; the percentage of migratory CD1a+ dermal DCs was significantly decreased in the DSS patients, and skin CD8+ T cells were ..
  92. Yu Q, Hui R, Park J, Huang Y, Kusnecov A, Dreyfus C, et al. Strain differences in cuprizone induced demyelination. Cell Biosci. 2017;7:59 pubmed publisher
    ..Here we investigated the contribution of genetic differences in response to cuprizone-induced demyelination in two genetically different mouse strains: CD1 and C57BL/6.