CD1a

Summary

Gene Symbol: CD1a
Description: CD1a molecule
Alias: CD1, FCB6, HTA1, T-cell surface glycoprotein CD1a, CD1A antigen, a polypeptide, T-cell surface antigen T6/Leu-6, cluster of differentiation 1 A, cortical thymocyte antigen CD1A, differentiation antigen CD1-alpha-3, epidermal dendritic cell marker CD1a, hTa1 thymocyte antigen
Species: human
Products:     CD1a

Top Publications

  1. Coventry B, Heinzel S. CD1a in human cancers: a new role for an old molecule. Trends Immunol. 2004;25:242-8 pubmed
  2. Shinya E, Owaki A, Shimizu M, Takeuchi J, Kawashima T, Hidaka C, et al. Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells. Virology. 2004;326:79-89 pubmed
    ..When iDCs were infected with HIV/VSV-G/+Nef, the surface expression of CD1a, a molecule for presenting glycolipid/lipid antigens, was selectively down-regulated among CD1 molecules (CD1a, -b, ..
  3. Van Rhijn I, Ly D, Moody D. CD1a, CD1b, and CD1c in immunity against mycobacteria. Adv Exp Med Biol. 2013;783:181-97 pubmed publisher
    The CD1 system is composed of five types of human CD1 proteins, CD1a, CD1b, CD1c, CD1d, and CD1e, and their mammalian orthologs...
  4. Adams E. Lipid presentation by human CD1 molecules and the diverse T cell populations that respond to them. Curr Opin Immunol. 2014;26:1-6 pubmed publisher
    CD1 molecules bind and present lipid-based antigens to T cells. Humans express both Group 1 (CD1a, CD1b and CD1c) and Group 2 (CD1d) CD1 molecules with nonredundant functions in the human immune response...
  5. Moody D, Young D, Cheng T, Rosat J, Roura Mir C, O Connor P, et al. T cell activation by lipopeptide antigens. Science. 2004;303:527-31 pubmed
    ..Here, we report that CD1a presents a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins ..
  6. Kallert S, Zenk S, Walther P, Grieshober M, Weil T, Stenger S. Liposomal delivery of lipoarabinomannan triggers Mycobacterium tuberculosis specific T-cells. Tuberculosis (Edinb). 2015;95:452-62 pubmed publisher
    ..for the activation of LAM-specific T-cells is the efficient uptake and transport of the glycolipid antigen to the CD1 antigen presenting machinery...
  7. Gilleron M, Lepore M, Layre E, Cala De Paepe D, Mebarek N, Shayman J, et al. Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens. Cell Chem Biol. 2016;23:1147-1156 pubmed publisher
    ..Complex antigens require processing within antigen-presenting cells (APCs) to form T cell stimulatory complexes with CD1 antigen-presenting molecules...
  8. Leonhardt I, Spielberg S, Weber M, Albrecht Eckardt D, Bläss M, Claus R, et al. The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. MBio. 2015;6:e00143 pubmed publisher
    ..Several markers important for maturation and antigen presentation like CD1a, CD83, CD86, and CD80 were significantly reduced in the presence of farnesol...
  9. Öğrenci A, Batcik O, Ekşi M, Koban O. Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it?. Childs Nerv Syst. 2016;32:1513-6 pubmed publisher
    ..b>CD1a was positive yet S100 was negative. Final diagnosis was eosinophilic granuloma...

More Information

Publications144 found, 100 shown here

  1. Sezer E, Oztürk Durmaz E, Cetin E, Sahin S. Meyerson Phenomenon as a Component of Melanoma in situ. Acta Dermatovenerol Croat. 2016;24:81-2 pubmed
    ..Immunohistochemical staining with the Langerhans cell marker, CD1a, revealed an increased cell population in the perilesional, erythematous halo (Figure 1, d)...
  2. Dossa R, Alperin D, Garzón D, Mealey R, Brown W, Jervis P, et al. In contrast to other species, α-Galactosylceramide (α-GalCer) is not an immunostimulatory NKT cell agonist in horses. Dev Comp Immunol. 2015;49:49-58 pubmed publisher
    GalCer is a potent immunomodulatory molecule that is presented to NKT cells via the CD1 antigen-presenting system...
  3. Saad A, Diken Z, Kechichian T, Clark S, Olson G, Saade G, et al. Pravastatin Effects on Placental Prosurvival Molecular Pathways in a Mouse Model of Preeclampsia. Reprod Sci. 2016;23:1593-1599 pubmed
    ..Pregnant CD1 mice at day 8 of gestation (length of gestation 19 days) were randomly allocated to injection via tail vein with ..
  4. Ascione R, Rowlinson J, Avolio E, Katare R, Meloni M, Spencer H, et al. Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction. Stem Cell Res Ther. 2015;6:53 pubmed publisher
    ..Cells groups were also intramyocardially injected in an in vivo model of MI (8-week-old immune deficient CD1-FOXN1(nu/nu) mice). Echocardiography and hemodynamic measurements were performed before and at 14 days post-MI...
  5. Gras S, Van Rhijn I, Shahine A, Le Nours J. Molecular recognition of microbial lipid-based antigens by T cells. Cell Mol Life Sci. 2018;75:1623-1639 pubmed publisher
    ..However, lipids represent an additional, distinct chemical class of molecules that when presented by the family of CD1 antigen-presenting molecules can serve as antigens, and be recognized by specialized subsets of T cells leading to ..
  6. Quigley H, Pitha I, Welsbie D, Nguyen C, Steinhart M, Nguyen T, et al. Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS ONE. 2015;10:e0141137 pubmed publisher
    ..We produced IOP increase in CD1 mice and performed unilateral optic nerve crush...
  7. Consonni M, Dellabona P, Casorati G. Potential advantages of CD1-restricted T cell immunotherapy in cancer. Mol Immunol. 2018;103:200-208 pubmed publisher
    ..b>CD1 antigen presenting molecules are nonpolymorphic and specialized for lipid antigen presentation to T cells...
  8. Kumar M, Adurthi S, Ramachandran S, Mukherjee G, Joy O, Krishnamurthy H, et al. Toll-like receptors 7, 8, and 9 expression and function in primary human cervical cancer Langerhans cells: evidence of anergy. Int J Gynecol Cancer. 2013;23:184-92 pubmed publisher
    ..Langerhans cells were further flow sorted into CD1a*CD207* cells. Acute monocytic leukemia cell line THP-1-derived LCs (moLCs) formed the controls...
  9. Grobost V, Khouatra C, Lazor R, Cordier J, Cottin V. Effectiveness of cladribine therapy in patients with pulmonary Langerhans cell histiocytosis. Orphanet J Rare Dis. 2014;9:191 pubmed publisher
    Pulmonary Langerhans cell histiocytosis (PLCH) is a rare disorder characterised by granulomatous proliferation of CD1a-positive histiocytes forming granulomas within lung parenchyma, in strong association with tobacco smoking, and which ..
  10. Moody D, Cotton R. Four pathways of CD1 antigen presentation to T cells. Curr Opin Immunol. 2017;46:127-133 pubmed publisher
    b>CD1a, CD1b, CD1c and CD1d proteins migrate through distinct subcellular compartments of antigen presenting cells and so can be considered to take four separate pathways leading to display of lipid antigens to T cell receptors...
  11. Yang P, Wu J, Miao L, Manaenko A, Matei N, Zhang Y, et al. Platelet-Derived Growth Factor Receptor-? Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice. Crit Care Med. 2016;44:e390-402 pubmed publisher
    ..Controlled in vivo laboratory study. Animal research laboratory. One hundred and fifty six eight-week-old male CD1 mice. Brain injury was induced by autologous arterial blood or plasmin injection into mouse brains...
  12. Renaud L, Harris L, Mani S, Kasiganesan H, CHOU J, Baicu C, et al. HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis. Circ Heart Fail. 2015;8:1094-104 pubmed publisher
    ..Transverse aortic constriction (TAC) was performed in CD1 mice to induce pressure overload hypertrophy...
  13. Zhu J, Xu Y, Rashedi A, Pavone M, Kim J, Woodruff T, et al. Human fallopian tube epithelium co-culture with murine ovarian follicles reveals crosstalk in the reproductive cycle. Mol Hum Reprod. 2016;22:756-767 pubmed
    ..6) who had not undergone exogenous hormonal treatment for at least 3 months prior to surgery. CD1 female mice were used for ovarian follicle isolation...
  14. Gunji Niitsu Y, Kumasaka T, Kitamura S, Hoshika Y, Hayashi T, Tokuda H, et al. Benign clear cell "sugar" tumor of the lung in a patient with Birt-Hogg-Dubé syndrome: a case report. BMC Med Genet. 2016;17:85 pubmed
    ..revealed that these tumor cells were positive for microphthalmia-transcription factor, S100, and CD1a but negative for HMB45, indicating that the tumor was a CCST...
  15. Campochiaro C, Tomelleri A, Cavalli G, Berti A, Dagna L. Erdheim-Chester disease. Eur J Intern Med. 2015;26:223-9 pubmed publisher
    ..Biopsy is necessary to establish a definite diagnosis with the identification of CD68+/CD1a-/S100- foamy histiocytes...
  16. Garrido A, Cruces J, Ceprián N, Hernandez Sanchez C, de la Fuente M. Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. A longitudinal study. Brain Behav Immun. 2018;69:440-455 pubmed publisher
    ..ICR-CD1 female TH-HZ and wild type (WT) mice were used in a longitudinal study...
  17. Gheorghe A, Pérez de Heredia F, Hunsche C, Redondo N, Díaz L, Hernández O, et al. Oxidative stress and immunosenescence in spleen of obese mice can be reversed by 2-hydroxyoleic acid. Exp Physiol. 2017;102:533-544 pubmed publisher
    ..Female ICR/CD1 mice (8 weeks old, n = 24) received an obesogenic diet (22% fat for 4 weeks and 60% fat for 14 weeks)..
  18. Venerosi A, Tait S, Stecca L, Chiarotti F, De Felice A, Cometa M, et al. Effects of maternal chlorpyrifos diet on social investigation and brain neuroendocrine markers in the offspring - a mouse study. Environ Health. 2015;14:32 pubmed publisher
    ..Pregnant CD1 outbred mice were fed from gestational day 15 to lactation day 14 with either a CPF-added (equivalent to 6 mg/kg/bw/..
  19. Schander J, Correa F, Bariani M, Blanco J, Cymeryng C, Jensen F, et al. A role for the endocannabinoid system in premature luteal regression and progesterone withdrawal in lipopolysaccharide-induced early pregnancy loss model. Mol Hum Reprod. 2016;22:800-808 pubmed
    ..b>CD1 wild-type (WT) and CB1-KO mice were randomly allocated to Vehicle (saline; i.p.) or LPS (0.5 ?g/g body weight; i.p...
  20. Ciolek J, Reinfrank H, Quinton L, Viengchareun S, Stura E, Vera L, et al. Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease. Proc Natl Acad Sci U S A. 2017;114:7154-7159 pubmed publisher
    ..b>CD1-pcy/pcy mice, a juvenile model of PKD, daily treated with 13 [Formula: see text]g of mambaquaretin-1 for 99 d, ..
  21. Li X, Wang Y, Chen R, Abulaiti D, Ma Z, Miao N, et al. [Clinicopathologic features and prognosis of T lymphoblastic lymphoma associated with Langerhans cell histiocytosis]. Zhonghua Bing Li Xue Za Zhi. 2014;43:522-7 pubmed
    ..The histiocytes were positive for CD1a, S-100 protein and CD68. The lymphoma cells were positive for CD3, CD7, TdT and CD34...
  22. Helyes Z, Kemény Ã, CsekÅ‘ K, SzÅ‘ke Ã, Elekes K, Mester M, et al. Marijuana smoke induces severe pulmonary hyperresponsiveness, inflammation, and emphysema in a predictive mouse model not via CB1 receptor activation. Am J Physiol Lung Cell Mol Physiol. 2017;313:L267-L277 pubmed publisher
    ..Therefore, we performed a systematic study in CD1 mice as a predictive animal model and assessed the pathophysiological alterations in response to 4-mo-long whole ..
  23. Barbati S, Colussi C, Bacci L, Aiello A, Re A, Stigliano E, et al. Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia. Endocrinology. 2017;158:2391-2405 pubmed publisher
    ..In CD1 mice, made hyperglycemic by streptozotoicin (STZ) injection, cardiac structural alterations were evident at 6 ..
  24. Guo S, Yan Q, Rohr J, Wang Y, Fan L, Wang Z. Erdheim-Chester disease involving the breast--a rare but important differential diagnosis. Hum Pathol. 2015;46:159-64 pubmed publisher
    ..and the typical immunoprofile (positive for cluster of differentiation 68 [CD68], CD163, and p16; negative for CD1a and S-100)...
  25. Hunsche C, Hernández O, Gheorghe A, Diaz L, Marcos A, De la Fuente M. Immune dysfunction and increased oxidative stress state in diet-induced obese mice are reverted by nutritional supplementation with monounsaturated and n-3 polyunsaturated fatty acids. Eur J Nutr. 2018;57:1123-1135 pubmed publisher
    ..Obesity was induced in adult female ICR/CD1 by the administration of a high-fat diet (HFD) for 14 weeks...
  26. Ianosi E, Muresan M, Gurzu S, Budin E, Jung I, Bara T, et al. Pulmonary Langerhans cell histiocytosis in a 26-year-old female: still a diagnostic challenge. Rom J Morphol Embryol. 2017;58:1047-1050 pubmed
    ..large cells with foamy cytoplasm and convoluted nuclei that were marked by CD68, S-100 and the specific antibody CD1a that allowed establishing the diagnosis of pulmonary LCH...
  27. Arabadzhieva E, Yonkov A, Bonev S, Bulanov D, Taneva I, Pirdopska T, et al. Rosai-Dorfman disease involving gallbladder and liver-Report of a case. Int J Surg Case Rep. 2015;12:140-2 pubmed publisher
    ..histiocytic proliferation, emperipolesis and positive immunostaining for S-100 protein and typically negative for CD1a. Gastrointestinal localization of RDD, especially in the liver and pancreas, is extremely rare...
  28. Huang B, Zhang H, Zong W, Sun Y. Rosai-Dorfman Disease of Rare Isolated Spinal Involvement: Report of 4 Cases and Literature Review. World Neurosurg. 2016;85:367.e11-6 pubmed publisher
    ..emperipolesis, and the lymphocytes were engulfed in the S-100-protein-positive histiocytes with no expression of CD1a. Preoperative diagnosis of spinal RDD is still challenging because the lesion is usually a dura-based lesion that ..
  29. Lundgren S, Karnevi E, Elebro J, Nodin B, Karlsson M, Eberhard J, et al. The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype. J Transl Med. 2017;15:152 pubmed publisher
    ..The density of tolerogenic immature CD1a+ dendritic cells (DC), and MARCO+, CD68+ and CD163+ tissue-associated ..
  30. Pena Cruz V, Ito S, Dascher C, Brenner M, Sugita M. Epidermal Langerhans cells efficiently mediate CD1a-dependent presentation of microbial lipid antigens to T cells. J Invest Dermatol. 2003;121:517-21 pubmed
    ..pathway of lipid antigen presentation has been identified and is mediated by molecules of the CD1 family (CD1a, CD1b, CD1c, and CD1d)...
  31. Dorival C, Brizzi F, Lelievre J, Sol Foulon N, Six E, Henry A, et al. HIV-1 Nef protein expression in human CD34+ progenitors impairs the differentiation of an early T/NK cell precursor. Virology. 2008;377:207-15 pubmed publisher
    ..We demonstrate that Nef impairs the generation of a CD3epsilon(+)CD5(+) CD1a(+) precursor stage that has initiated a D-J rearrangement of the TCRbeta locus...
  32. Kurosawa N, Shimizu K, Seki K. The development of depression-like behavior is consolidated by IL-6-induced activation of locus coeruleus neurons and IL-1β-induced elevated leptin levels in mice. Psychopharmacology (Berl). 2016;233:1725-37 pubmed publisher
    ..Adult male CD1 mice were treated with LPS (1 mg/kg, i.p...
  33. Huang C, Liu H, Gong X, Wen B, Chen D, Liu J, et al. Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis. Mol Med Rep. 2016;14:2555-65 pubmed publisher
    ..Crumbs3 (CRB3), vimentin, proteinase activated receptor 3 (PAR?3), ??smooth muscle actin (??SMA), cyclin D1 (CD1) and cluster of differentiation (CD)133. In addition, crypt architecture was observed...
  34. Kaneko H, Kikuchi K, Men N, Nakai M, Noguchi J, Kashiwazaki N, et al. Production of sperm from porcine fetal testicular tissue after cryopreservation and grafting into nude mice. Theriogenology. 2017;91:154-162 pubmed publisher
    ..testicular fragments at each fetal stage were transplanted under the back skin of castrated nude mice (Crlj:CD1-Foxn1nu) (35-, 55- and 90-dpi groups, respectively) (day 0 = grafting)...
  35. Esendagli G, Canpinar H, Yilmaz G, Kaymaz F, Kansu E, Guc D. Fibronectin promotes the phorbol 12-myristate 13-acetate-induced macrophage differentiation in myeloid leukemia cells. Int J Hematol. 2009;89:167-172 pubmed publisher
    ..CD15 and alpha-naphthyl-acetate esterase was also maintained, however, differentiated HL60 cells were HLA-DR and CD1a negative...
  36. Li D, Hong A, Lu Q, Gao G, Jin B, Screaton G, et al. A novel role of CD1c in regulating CD1d-mediated NKT cell recognition by competitive binding to Ig-like transcript 4. Int Immunol. 2012;24:729-37 pubmed publisher
    Humans express four MHC-like CD1 molecules CD1a, b, c and d that are capable of presenting a wide variety of self or foreign lipid antigens to T cells...
  37. Shinya E, Shimizu M, Owaki A, Paoletti S, Mori L, De Libero G, et al. Hemopoietic cell kinase (Hck) and p21-activated kinase 2 (PAK2) are involved in the down-regulation of CD1a lipid antigen presentation by HIV-1 Nef in dendritic cells. Virology. 2016;487:285-95 pubmed publisher
    ..To understand the exact role of DCs and CD1-mediated immune response during HIV-1 infection, Nef down-regulation of CD1a-restricted lipid/glycolipid Ag presentation in iDCs was analyzed...
  38. Schjaerff M, Keller S, Fass J, Froenicke L, Grahn R, Lyons L, et al. Refinement of the canine CD1 locus topology and investigation of antibody binding to recombinant canine CD1 isoforms. Immunogenetics. 2016;68:191-204 pubmed publisher
    ..The canine (Canis familiaris) CD1 locus was previously found to contain three functional CD1A genes: canCD1A2, canCD1A6, and canCD1A8, where two variants of canCD1A8, canCD1A8.1 and canCD1A8...
  39. Alasmari F, Crotty Alexander L, Nelson J, Schiefer I, Breen E, Drummond C, et al. Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and α-7 nicotinic acetylcholine receptor in female CD-1 mice. Prog Neuropsychopharmacol Biol Psychiatry. 2017;77:1-8 pubmed publisher
    ..on GLT-1, xCT, and GLAST expression in frontal cortex (FC), striatum (STR), and hippocampus (HIP) in outbred female CD1 mice...
  40. Jodeleit H, Palamides P, Beigel F, Mueller T, Wolf E, Siebeck M, et al. Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model. J Transl Med. 2017;15:265 pubmed publisher
    ..Analysis of leukocytes isolated from the spleen of challenged NSG-UC mice corroborated CD64, CD163 and CD1a expressing CD14+ monocytes, CD1a expressing CD11b+ macrophages and HGF, TARC, IFNγ and TGFß1 mRNA as inflammatory ..
  41. Leon L, Tatituri R, Grenha R, Sun Y, Barral D, Minnaard A, et al. Saposins utilize two strategies for lipid transfer and CD1 antigen presentation. Proc Natl Acad Sci U S A. 2012;109:4357-64 pubmed publisher
    Transferring lipid antigens from membranes into CD1 antigen-presenting proteins represents a major molecular hurdle necessary for T-cell recognition. Saposins facilitate this process, but the mechanisms used are not well understood...
  42. Li Y, Rabey K, Schmitt D, Norton J, Reynolds R. Characteristics of Vibration that Alter Cardiovascular Parameters in Mice. J Am Assoc Lab Anim Sci. 2015;54:372-7 pubmed
    ..We used radiotelemetry to evaluate the cardiovascular response to vibration in C57BL/6 and CD1 male mice exposed to vertical vibration of various frequencies and accelerations...
  43. Giuliano A, Swift R, Arthurs C, Marote G, Abramo F, McKay J, et al. Quantitative Expression and Co-Localization of Wnt Signalling Related Proteins in Feline Squamous Cell Carcinoma. PLoS ONE. 2016;11:e0161103 pubmed publisher
    ..We tested for the expression of four key Wnt/ß-catenin transcription targets, namely Cyclin D1 (CCND1 or CD1), FRA1, c-Myc and MMP7. All antibodies showed cross reactivity in feline tissue except MMP7...
  44. Herrmann M, Opitz S, Harzer R, Totsche K, Küsel K. Attached and Suspended Denitrifier Communities in Pristine Limestone Aquifers Harbor High Fractions of Potential Autotrophs Oxidizing Reduced Iron and Sulfur Compounds. Microb Ecol. 2017;74:264-277 pubmed publisher
    ..Quantitative PCR and amplicon pyrosequencing of nirK and nirS genes encoding copper-containing or cytochrome cd1 heme-type nitrite reductase, respectively, and of bacterial 16S ribosomal RNA genes showed a numerical predominance ..
  45. Canto de Souza L, Provensi G, Vullo D, Carta F, Scozzafava A, Costa A, et al. Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus. Neuropharmacology. 2017;118:148-156 pubmed publisher
    ..Systemic administration of acetazolamide to male CD1 mice caused amnesia in the ORT and reduced CA activity in brain homogenates, while treatment with d-phenylalanine ..
  46. Tardio J, Aguado M, Borbujo J. Self-regressing S100-negative CD1a-positive cutaneous histiocytosis. Am J Dermatopathol. 2013;35:e57-9 pubmed publisher
    ..We report a case of a cutaneous-limited self-regressing histiocytosis with a peculiar immunohistochemical profile (CD1a-positive and S100 protein-negative) that is not observed in any of the known cutaneous antigen-presenting cell or ..
  47. Polettini J, Behnia F, Taylor B, Saade G, Taylor R, Menon R. Telomere Fragment Induced Amnion Cell Senescence: A Contributor to Parturition?. PLoS ONE. 2015;10:e0137188 pubmed publisher
    ..T-oligos injected into the uteri of pregnant CD1 mice on day 14 of gestation, led to increased p38MAPK, SA-β-gal (SA β-gal) staining in murine amniotic sacs ..
  48. Kendall L, Wegenast D, Smith B, Dorsey K, Kang S, Lee N, et al. Efficacy of Sustained-Release Buprenorphine in an Experimental Laparotomy Model in Female Mice. J Am Assoc Lab Anim Sci. 2016;55:66-73 pubmed
    ..Female CD1 mice underwent laparotomy and received either Bup-SR (0.6 mg/kg), Bup-HCl (0...
  49. Preidis G, Ajami N, Wong M, Bessard B, Conner M, Petrosino J. Microbial-Derived Metabolites Reflect an Altered Intestinal Microbiota during Catch-Up Growth in Undernourished Neonatal Mice. J Nutr. 2016;146:940-8 pubmed publisher
    ..Male and female CD1 mouse pups were undernourished by timed separation from lactating dams for 4 h at 5 d of age, 8 h at 6 d of age, ..
  50. Vishnubalaji R, Atteya M, Al Nbaheen M, Oreffo R, Aldahmash A, Alajez N. Angiogenic Potential of Human Neonatal Foreskin Stromal Cells in the Chick Embryo Chorioallantoic Membrane Model. Stem Cells Int. 2015;2015:257019 pubmed publisher
    ..a propensity to differentiate towards ectoderm with indication of epidermal formation with cells positive for CD1a, CK5/6, CK19, FXIIIa, and S-100 cells, which warrant further investigation...
  51. Martini A, Berta T, Forner S, Chen G, Bento A, Ji R, et al. Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection. J Neuroinflammation. 2016;13:75 pubmed publisher
    ..Spinal hemisection at T10 was carried out in adult male CD1 mice and Wistar rats...
  52. Tallis J, Higgins M, Seebacher F, Cox V, Duncan M, James R. The effects of 8?weeks voluntary wheel running on the contractile performance of isolated locomotory (soleus) and respiratory (diaphragm) skeletal muscle during early ageing. J Exp Biol. 2017;220:3733-3741 pubmed publisher
    ..wheel running on the contractile performance of isolated dynapenic soleus and diaphragm muscles of 38-week-old CD1 mice...
  53. Duyen H, Cerny D, Trung D, Pang J, Velumani S, Toh Y, et al. Skin dendritic cell and T cell activation associated with dengue shock syndrome. Sci Rep. 2017;7:14224 pubmed publisher
    ..analyzed cell subsets by flow cytometry, and soluble mediators and antibodies by ELISA; the percentage of migratory CD1a+ dermal DCs was significantly decreased in the DSS patients, and skin CD8+ T cells were ..
  54. Kuijf M, Geleijns K, Ennaji N, van Rijs W, van Doorn P, Jacobs B. Susceptibility to Guillain-Barré syndrome is not associated with CD1A and CD1E gene polymorphisms. J Neuroimmunol. 2008;205:110-2 pubmed publisher
    ..This hypothesis was tested by comparing single nucleotide polymorphisms (SNPs) of CD1A and CD1E in 312 well defined GBS patients and 212 healthy controls...
  55. Paquin Proulx D, Santos B, Carvalho K, Toledo Barros M, Oliveira A, Kokron C, et al. Dysregulated CD1 profile in myeloid dendritic cells in CVID is normalized by IVIg treatment. Blood. 2013;121:4963-4 pubmed publisher
  56. Auray G, Keller I, Python S, Gerber M, Bruggmann R, Ruggli N, et al. Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences. J Immunol. 2016;197:4791-4806 pubmed
    ..cDC2 are CD135+CD14-CD172a+CADM1+CD115+wCD11R1+CD1+ cells and pDCs are CD4+CD135+CD172a+CD123+CD303+ ..
  57. Johnson J, Taylor D, Green A, Gaskill B. Effects of Nesting Material on Energy Homeostasis in BALB/cAnNCrl, C57BL/6NCrl, and Crl:CD1(ICR) Mice Housed at 20 °C. J Am Assoc Lab Anim Sci. 2017;56:254-259 pubmed
    ..Groups of BALB/cAnNCrl, C57BL/6NCrl, and Crl:CD1(ICR) mice, balanced by strain and sex, were group-housed and provided 0, 6, or 12 g of nesting material...
  58. Huidobro Chávez A, Vigo Pareja G, Pachas Peña C, Patiño Calla K. [Langerhans cell histiocytosis with orbital involvement in an infant: Case report]. Arch Argent Pediatr. 2018;116:e283-e287 pubmed publisher
    The Langerhans cell histiocytosis is a rare disease characterized by the clonal proliferation of CD1a + myeloid dendritic cells associated with a significant inflammatory component...
  59. Zhou D, Cantu C, Sagiv Y, Schrantz N, Kulkarni A, Qi X, et al. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science. 2004;303:523-7 pubmed
    It is now established that CD1 molecules present lipid antigens to T cells, although it is not clear how the exchange of lipids between membrane compartments and the CD1 binding groove is assisted...
  60. Agod Z, Pazmandi K, Bencze D, Vereb G, Biro T, Szabo A, et al. Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8. Front Immunol. 2018;9:62 pubmed publisher
    ..Furthermore, we demonstrate that SLAMF5 influences the ratio of CD1a+ cells in differentiating DCs and partakes in the regulation of IL-1β, IL-23, and IL-12 production in ..
  61. Witherspoon L, O Reilly S, Hadwen J, Tasnim N, MacKenzie A, Farooq F. Sodium Channel Inhibitors Reduce DMPK mRNA and Protein. Clin Transl Sci. 2015;8:298-304 pubmed publisher
    ..In vivo analysis of CD1 mice also showed DMPK mRNA and protein down-regulation...
  62. Mazaya B, Hamzawy M, Khalil M, Tawkol W, Sabit H. Immunomodulatory and antimicrobial efficacy of Lactobacilli against enteropathogenic infection of Salmonella typhi: In-vitro and in-vivo study. Int J Immunopathol Pharmacol. 2015;28:469-78 pubmed publisher
    ..Their antimicrobial activities were tested against different bacterial strains. Six groups of CD1 mice were treated for 8 days as follows: group (1) untreated control; group (2) was challenged with single ..
  63. Flannery C, Fleming A, Choe G, Naqvi H, Zhang M, Sharma A, et al. Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium. Endocrinology. 2016;157:3699-3708 pubmed
    ..In vitro, BZA reduced FGF18, but did not affect, HAND2. CD1 female mice received either BZA, conjugated estrogen (CE), or combined BZA/CE for 8 weeks...
  64. Zuo H, Zhang J, Zhang L, Ren X, Chen X, Hao H, et al. Transcriptomic Variation during Spermiogenesis in Mouse Germ Cells. PLoS ONE. 2016;11:e0164874 pubmed publisher
    ..in the transcription activity during spermiogenesis, round and elongated spermatids were collected from ICR/CD1 model mice using laser capture microdissection (LCM) and cauda epididymal sperm samples...
  65. Popper H. [Pulmonary Langerhans cell histiocytosis]. Pathologe. 2015;36:451-7 pubmed publisher
    ..Langerhans cells can be selectively detected with antibodies against CD1a and langerin...
  66. Gao Q, Zhao S, Qin T, Yin Y, Yu Q, Yang Q. Effects of inactivated porcine epidemic diarrhea virus on porcine monocyte-derived dendritic cells and intestinal dendritic cells. Res Vet Sci. 2016;106:149-58 pubmed publisher
    ..In this study, our results show that the expression of Mo-DCs surface markers such as SWC3a(+)CD1a(+), SWC3a(+)CD80/86(+) and SWC3a(+)SLA-II-DR(+) is increased after incubation with UV-PEDV for 24h...
  67. Fernandez Flores A. A new scenario in the immunohistochemical diagnosis of cutaneous leishmaniasis. J Cutan Pathol. 2017;44:1051-1052 pubmed publisher
    ..Pathology also welcomed the unexpected positivity of amastigotes with certain clones of anti-CD1a. The latter does not universally stain all species of Leishmania, with a low sensitivity for New World species...
  68. Mendler C, Gehring T, Wester H, Schwaiger M, Skerra A. ⁸⁹Zr-Labeled Versus ¹²⁴I-Labeled αHER2 Fab with Optimized Plasma Half-Life for High-Contrast Tumor Imaging In Vivo. J Nucl Med. 2015;56:1112-8 pubmed publisher
    ..of both radioconjugates and quality control in vitro, immuno-PET and biodistribution studies were performed with CD1-Foxn1(nu) mice bearing HER2-positive human tumor xenografts...
  69. Chabasse C, Siefert S, Chaudry M, Hoofnagle M, Lal B, Sarkar R. Recanalization and flow regulate venous thrombus resolution and matrix metalloproteinase expression in vivo. J Vasc Surg Venous Lymphat Disord. 2015;3:64-74 pubmed publisher
    ..In CD1 mice, we performed surgical inferior vena cava ligation (stasis thrombosis), stenosis (thrombosis with ..
  70. Fachin L, Soares C, Belone A, Trombone A, Rosa P, Guidella C, et al. Immunohistochemical assessment of cell populations in leprosy-spectrum lesions and reactional forms. Histol Histopathol. 2017;32:385-396 pubmed publisher
    ..and quantitative immunohistochemical analyses were performed to detect CD3, CD4, CD8, FoxP3, CD20, CD138, CD1a, CD57, CD15, CD117, CD68, and CD163. In addition, histochemistry was employed to identify eosinophils...
  71. Bagchi S, Li S, Wang C. CD1b-autoreactive T cells recognize phospholipid antigens and contribute to antitumor immunity against a CD1b+ T cell lymphoma. Oncoimmunology. 2016;5:e1213932 pubmed
    ..CD1 molecules, which present self- and foreign lipid antigens to T cells, are divided into group 1 (CD1a, CD1b, and CD1c) and group 2 (CD1d)...
  72. Manaenko A, Yang P, Nowrangi D, Budbazar E, Hartman R, Obenaus A, et al. Inhibition of stress fiber formation preserves blood-brain barrier after intracerebral hemorrhage in mice. J Cereb Blood Flow Metab. 2018;38:87-102 pubmed publisher
    ..In the present study, we investigated the effect of ICH on stress fiber formation in CD1 mice...
  73. Zhang L, Li Y, Shen W, Wang S, Wang G, Zhou Y. Whole-genome sequence of a carbapenem-resistant hypermucoviscous Klebsiella pneumoniae isolate SWU01 with capsular serotype K47 belonging to ST11 from a patient in China. J Glob Antimicrob Resist. 2017;11:87-89 pubmed publisher
    ..capsular serotype was analysed using the BIGSdb-Kp database with the nucleotide sequence of the variable region (CD1-VR2-CD2) of wzc...
  74. Schulke L, Berbic M, Manconi F, Tokushige N, Markham R, Fraser I. Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis. Hum Reprod. 2009;24:1695-703 pubmed publisher
    ..The aim of this study was to investigate DC populations in the eutopic and ectopic endometrium of women with endometriosis compared with controls...
  75. Gorina Y, Komleva Y, Lopatina O, Volkova V, Chernykh A, Shabalova A, et al. [The battery of tests for behavioral phenotyping of aging animals in the experiment]. Adv Gerontol. 2017;30:49-55 pubmed
    ..Object of the study were outbred CD1 mice in the following groups: 1st group - 12-month old male mice (physiological aging); 2nd group - 2-month old ..
  76. Hilly O, Strenov Y, Rath Wolfson L, Hod R, Shkedy Y, Mizrachi A, et al. The predictive value of dendritic cells in early squamous cell carcinoma of the tongue. Pathol Res Pract. 2016;212:1138-1143 pubmed publisher
    ..local complete excision and elective selective neck dissection, were immunostained with antibodies against S100 and CD1a. Dendritic cell density was analyzed by outcome...
  77. Tallis J, James R, Cox V, Duncan M. Is the Ergogenicity of Caffeine Affected by Increasing Age? The Direct Effect of a Physiological Concentration of Caffeine on the Power Output of Maximally Stimulated EDL and Diaphragm Muscle Isolated from the Mouse. J Nutr Health Aging. 2017;21:440-448 pubmed publisher
    ..Female CD1 mice were aged to 3, 10, 30 and 50 weeks (n = 20 in each case) and either whole EDL or a section of the diaphragm ..
  78. Clark S, Purcell J, Bi X, Fortman J. Cross-Foster Rederivation Compared with Antibiotic Administration in the Drinking Water to Eradicate Bordetella pseudohinzii. J Am Assoc Lab Anim Sci. 2017;56:47-51 pubmed
    ..pseudohinzii to B. pseudohinzii-negative Crl:CD1-Elite surrogate dams. To evaluate antibiotic administration, sulfamethoxazole and trimethoprim (TMS; 0.66 and 0...
  79. La Rocca G, Anzalone R, Corrao S, Magno F, Rappa F, Marasà S, et al. CD1a down-regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome. Histopathology. 2008;52:203-12 pubmed publisher
    b>CD1a is a molecule belonging to the highly conserved group of CD1 proteins...
  80. Mokuda S, Miyazaki T, Ubara Y, Kanno M, Sugiyama E, Takasugi K, et al. CD1a+ survivin+ dendritic cell infiltration in dermal lesions of systemic sclerosis. Arthritis Res Ther. 2015;17:275 pubmed publisher
    ..3%, 9/14) was higher than that in non-SSc dermis (11.2%, 1/9). Furthermore, survivin+ cells expressed CD1a, one of the DC markers...
  81. Casorati G, Dellabona P. Of self-lipids, CD1-restricted T cells, and contact sensitization. Eur J Immunol. 2017;47:1119-1122 pubmed publisher
    ..implying that common small molecule CSs such as dinitrochlorobenzene can also recruit and activate autoreactive CD1-restricted T cells specific for cell-endogenous lipids, which are enriched in human skin...
  82. Van Rhijn I, Godfrey D, Rossjohn J, Moody D. Lipid and small-molecule display by CD1 and MR1. Nat Rev Immunol. 2015;15:643-54 pubmed publisher
    ..The use of tetramers of human CD1a, CD1b, CD1c or MR1 proteins now allows detailed analysis of the human T cell repertoire, which has revealed new ..
  83. Mester B, Bauer E, Wood C, Hermans I, Gasser O. Expression of CD1a and Type-1 Polarization Are Dissociated in Human Monocyte-Derived Dendritic Cells. PLoS ONE. 2015;10:e0140432 pubmed publisher
    ..However, expression of CD1d on moDC has been shown to be negatively correlated with expression of CD1a, which in turn has been suggested to be a surrogate marker for IL-12 secreting type-1 polarized moDC, the preferred ..
  84. Ivy C, Scott G. Ventilatory acclimatization to hypoxia in mice: Methodological considerations. Respir Physiol Neurobiol. 2017;235:95-103 pubmed publisher
    We examined ventilatory acclimatization to hypoxia (VAH) in CD1 mice, and contrasted results obtained using the barometric method on unrestrained mice with pneumotachography and pulse oximetry on restrained mice...
  85. Martínez de Toda I, Vida C, De la Fuente M. An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity. Int J Mol Sci. 2017;18: pubmed publisher
    ..An individualized longitudinal study was performed on female ICR-CD1 mice, starting at the adult age (40 weeks old), analyzing the proliferation of peritoneal leukocytes at different ..
  86. Darling M, Su N, Masen S, Kwon P, Fortino D, McKerlie T, et al. Geographic tongue: assessment of peripheral nerve status, Langerhans cell, and HLA-DR expression. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124:371-377.e1 pubmed publisher
    ..samples of GT were examined by using routine immunoperoxidase staining methods to S100 protein, neurofilament, CD1a, and HLA class II. The Student t test and Mann-Whitney U test were used to assess statistical significance...
  87. Strekalova T, Bahzenova N, Trofimov A, Schmitt Böhrer A, Markova N, Grigoriev V, et al. Pro-neurogenic, Memory-Enhancing and Anti-stress Effects of DF302, a Novel Fluorine Gamma-Carboline Derivative with Multi-target Mechanism of Action. Mol Neurobiol. 2018;55:335-349 pubmed publisher
    ..Both compounds supressed inter-male aggression in CD1 mice, the most eminent being the effects of DF302 in its highest dose...
  88. Lee W, Khan A, Curley J. Major urinary protein levels are associated with social status and context in mouse social hierarchies. Proc Biol Sci. 2017;284: pubmed publisher
    ..We housed groups of adult outbred CD1 male mice in a complex social environment for three weeks and collected urine samples from all individuals ..
  89. Salam H, Shahid R, Mirza T. Langerhans Cell Histiocytosis Involving Both Jaws in an Adult. J Coll Physicians Surg Pak. 2017;27:S89-S91 pubmed publisher
    ..Multiple incisional biopsies were performed and a diagnosis of LCH was confirmed by routine histopathological analysis followed by immunohistochemical staining for S-100 and CD1a.
  90. Sugimoto K, Ueda S, Okada M, Takemura T. Membranoproliferative glomerulonephritis associated with Rosai-Dorfman disease. Clin Nephrol Case Stud. 2017;5:54-59 pubmed publisher
    ..Immunohistochemistry for S-100 protein, CD68, and lysozyme was positive within the interstitium. CD1a staining was absent. These findings were diagnostic for membranoproliferative glomerulonephritis...
  91. Mardi K, Thakur R, Negi L. Intradural Eosinophilic Granuloma Invading Skull: Case Report and Review of the Literature. Asian J Neurosurg. 2017;12:698-700 pubmed publisher
    ..Right parietal extended craniotomy was done with the excision of mass from the dura. Histopathological features of mass were characteristic of eosinophilic granuloma which was confirmed by positive immunohistochemical staining for CD1a.
  92. Wang X, Xu M, Shi L, Ding Y, Cheng Q, Zhao Y. [Clinicopathologic analysis of micronodular thymoma with lymphoid stroma]. Zhonghua Bing Li Xue Za Zhi. 2017;46:837-840 pubmed publisher
    ..Stains for EMA, CD117, calretinin, TTF1 were negative in the tumor cells.Scattered CD3, CD1a, and TdT positive immature T lymphocytes were noted in and around tumor nodules...