Gene Symbol: CD18
Description: integrin subunit beta 2
Alias: CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin beta-2, cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor), complement component 3 receptor 3 and 4 subunit, complement receptor C3 beta-subunit, integrin beta chain, beta 2, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), leukocyte cell adhesion molecule CD18, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
Species: human
Products:     CD18

Top Publications

  1. Eich C, de Vries I, Linssen P, de Boer A, Boezeman J, Figdor C, et al. The lymphoid chemokine CCL21 triggers LFA-1 adhesive properties on human dendritic cells. Immunol Cell Biol. 2011;89:458-65 pubmed publisher
    ..A thorough understanding of the adhesive events during the DC life cycle will help to improve the outcome of DC-based antitumor clinical trials. ..
  2. Bianchi E, Denti S, Granata A, Bossi G, Geginat J, Villa A, et al. Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Nature. 2000;404:617-21 pubmed
    ..We suggest that signalling through the LFA-1 integrin may affect c-Jun-driven transcription by regulating JAB1 nuclear localization. This represents a new pathway for integrin-dependent modulation of gene expression. ..
  3. Reyes Reyes M, Mora N, Gonzalez G, Rosales C. beta1 and beta2 integrins activate different signalling pathways in monocytes. Biochem J. 2002;363:273-80 pubmed
    ..These data suggest that distinct integrins activate different signalling pathways in monocytic cells. ..
  4. Li Y, Zhang L. The fourth blade within the beta-propeller is involved specifically in C3bi recognition by integrin alpha M beta 2. J Biol Chem. 2003;278:34395-402 pubmed
  5. Vorup Jensen T, Carman C, Shimaoka M, Schuck P, Svitel J, Springer T. Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2. Proc Natl Acad Sci U S A. 2005;102:1614-9 pubmed
    ..The observations suggest that the pericellular proteolysis at the leading edge of neutrophils not only facilitates passage through the extracellular matrix but also manufactures binding sites for alphaXbeta2. ..
  6. Shibuya K, Lanier L, Phillips J, Ochs H, Shimizu K, Nakayama E, et al. Physical and functional association of LFA-1 with DNAM-1 adhesion molecule. Immunity. 1999;11:615-23 pubmed
    ..In addition, cross-linking of LFA-1 induces tyrosine phosphorylation of DNAM-1, for which the Fyn protein tyrosine kinase is responsible. These results indicate that DNAM-1 is involved in the LFA-1-mediated intracellular signals. ..
  7. Cairo C, Mirchev R, Golan D. Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clustering. Immunity. 2006;25:297-308 pubmed
    ..Our results suggest that current models of LFA-1 regulation are incomplete and that LFA-1 confinement by cytoskeletal attachment regulates cell adhesion both negatively and positively. ..
  8. Sotiriou S, Orlova V, Al Fakhri N, Ihanus E, Economopoulou M, Isermann B, et al. Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin. FASEB J. 2006;20:559-61 pubmed
    ..These observations suggest a novel mechanism for the atherogenic properties of Lp(a). ..
  9. Mahalingam B, Ajroud K, Alonso J, Anand S, Adair B, Horenstein A, et al. Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. J Immunol. 2011;187:6393-401 pubmed publisher
    ..As with other ligand-mimetic integrin antagonists, the function-blocking mAb 107 binds MIDAS of integrin CD11b/CD18 A domain (CD11bA), but in contrast, it favors the inhibitory Ca(2+) ion over the Mg(2+) ion at MIDAS...

More Information

Publications121 found, 100 shown here

  1. Ostermann G, Weber K, Zernecke A, Schröder A, Weber C. JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol. 2002;3:151-8 pubmed
    ..Thus, JAM-1 is a counter-receptor for LFA-1 that is ideally situated to guide and control transmigration during leukocyte recruitment. ..
  2. Porter J, Bracke M, Smith A, Davies D, Hogg N. Signaling through integrin LFA-1 leads to filamentous actin polymerization and remodeling, resulting in enhanced T cell adhesion. J Immunol. 2002;168:6330-5 pubmed
    ..The findings demonstrate that LFA-1 acts not only as an adhesion receptor but also as a signaling receptor by actively initiating the F-actin reorganization that is essential for many T cell-dependent processes. ..
  3. Xie C, Zhu J, Chen X, Mi L, Nishida N, Springer T. Structure of an integrin with an alphaI domain, complement receptor type 4. EMBO J. 2010;29:666-79 pubmed publisher
    ..Differences among 10 molecules in crystal lattices provide unprecedented information on interdomain flexibility important for modelling integrin extension and activation. ..
  4. Wang L, Gordon R, Huynh L, Su X, Park Min K, Han J, et al. Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity. 2010;32:518-30 pubmed publisher
    ..These results provide an indirect mechanism of cross-inhibition of TLRs and delineate a signaling pathway important for deactivation of macrophages. ..
  5. Gower R, Wu H, Foster G, Devaraj S, Jialal I, Ballantyne C, et al. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol. 2011;31:160-6 pubmed publisher
    ..Involvement of ?(2)-integrin CD11c/CD18 in atherogenesis was recently shown in dyslipidemic mice, which motivates our study of its inflammatory function ..
  6. Feigelson S, Pasvolsky R, Cemerski S, Shulman Z, Grabovsky V, Ilani T, et al. Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state. J Immunol. 2010;185:7394-404 pubmed publisher
  7. Hogg N, Patzak I, Willenbrock F. The insider's guide to leukocyte integrin signalling and function. Nat Rev Immunol. 2011;11:416-26 pubmed publisher
    ..This Review focuses on the integrin lymphocyte function-associated antigen 1 (LFA1; also known as ?L?2 integrin), which is expressed by T cells, and explores how disparate signalling pathways synergize to regulate LFA1 activity. ..
  8. Kim M, Carman C, Springer T. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science. 2003;301:1720-5 pubmed
  9. Liang S, Fu C, Wagner D, Guo H, Zhan D, Dong C, et al. Two-dimensional kinetics of beta 2-integrin and ICAM-1 bindings between neutrophils and melanoma cells in a shear flow. Am J Physiol Cell Physiol. 2008;294:C743-53 pubmed publisher
    ..These findings provide new quantitative understanding of the biophysical basis of leukocyte-tumor cell interactions mediated by specific receptor-ligand interactions under shear flow conditions. ..
  10. Rodríguez Fernandez J, Gomez M, Luque A, Hogg N, Sanchez Madrid F, Cabanas C. The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes. Mol Biol Cell. 1999;10:1891-907 pubmed
  11. Kim K, Wang L, Hwang I. A novel flow cytometric high throughput assay for a systematic study on molecular mechanisms underlying T cell receptor-mediated integrin activation. PLoS ONE. 2009;4:e6044 pubmed publisher
  12. Kulkarni M, Bowman E, Gabriel J, Amburgy T, Mayne E, Zidar D, et al. Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection. Open Forum Infect Dis. 2016;3:ofw224 pubmed publisher
    ..adhesion molecule expression (lymphocyte function-associated antigen 1 [LFA-1], macrophage-1 antigen [Mac-1], CD11c/CD18, very late antigen [VLA]-4) and the fractalkine receptor (CX3CR1); these receptors recognize ligands (intercellular ..
  13. de Vries T, Andreotta S, Loos B, Nicu E. Genes Critical for Developing Periodontitis: Lessons from Mouse Models. Front Immunol. 2017;8:1395 pubmed publisher
    ..g., Icam-1, P-selectin, Beta2-integrin/Cd18), for pathogen recognition and killing (e.g., Tlr2, Tlr4, Lamp-2), immune modulatory molecules (e.g...
  14. Wu H, Gower R, Wang H, Perrard X, Ma R, Bullard D, et al. Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia. Circulation. 2009;119:2708-17 pubmed publisher
    ..CD11c/CD18, a beta2 integrin expressed on human monocytes and a subset of mouse monocytes, has been shown to play a distinct ..
  15. Pick R, Begandt D, Stocker T, Salvermoser M, Thome S, Böttcher R, et al. Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity. Blood. 2017;130:847-858 pubmed publisher
    ..critically depends on the ?2 integrins lymphocyte function-associated antigen 1 (LFA-1) (CD11a/CD18) and macrophage-1 antigen (CD11b/CD18)...
  16. Zhang X, Li L, Li N, Shu X, Zhou L, Lü S, et al. Salt bridge interactions within the ?2 integrin ?7 helix mediate force-induced binding and shear resistance ability. FEBS J. 2017;: pubmed publisher
    ..This article is protected by copyright. All rights reserved...
  17. Montresor A, Toffali L, Mirenda M, Rigo A, Vinante F, Laudanna C. JAK2 tyrosine kinase mediates integrin activation induced by CXCL12 in B-cell chronic lymphocytic leukemia. Oncotarget. 2015;6:34245-57 pubmed publisher
    ..Our results reveal JAK2 as critical component of chemokine signaling in CLL B-lymphocytes and indicate JAK inhibition as a potentially useful new pharmacological approach to B-CLL treatment. ..
  18. Atashi A, Islami M, Mortazavi Y, Soleimani M. Homing Genes Expression in Fucosyltransferase VI-Treated Umbilical Cord Blood CD133+ Cells which Expanded on Protein-Coated Nanoscaffolds. Mol Biotechnol. 2018;60:455-467 pubmed publisher
    ..FCS-PLLA scaffolds provided optimal conditions for viability of FT-VI-treated CD133+ cells, and clonogenicity with the goal of improving homing following UCB-HSCs transplantation. ..
  19. Cao W, Wu X, Jia G, Zhao H, Chen X, Wu C, et al. New insights into the role of dietary spermine on inflammation, immune function and related-signalling molecules in the thymus and spleen of piglets. Arch Anim Nutr. 2017;71:175-191 pubmed publisher
    ..05). In summary, dietary spermine supplementation can alleviate inflammatory response, enhance the immune function and regulate the gene expression of signalling molecules related to inflammation...
  20. Martinez J, Molinaro R, Hartman K, Boada C, Sukhovershin R, De Rosa E, et al. Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery. Theranostics. 2018;8:1131-1145 pubmed publisher
    ..Furthermore, leukosomes can potentially be loaded with therapeutics possessing diverse physical properties and thus warrant further investigation toward the development of powerful theranostic agents. ..
  21. Pilat N, Sabler P, Klaus C, Mahr B, Unger L, Hock K, et al. Blockade of adhesion molecule lymphocyte function-associated antigen-1 improves long-term heart allograft survival in mixed chimeras. J Heart Lung Transplant. 2018;37:1119-1130 pubmed publisher
    ..Our findings demonstrate the potential of a clinically relevant minimal conditioning protocol designed to induce lifelong immunologic tolerance toward cardiac allografts. ..
  22. Dominguez G, Anderson N, Hammer D. The direction of migration of T-lymphocytes under flow depends upon which adhesion receptors are engaged. Integr Biol (Camb). 2015;7:345-55 pubmed publisher
    ..These results indicate that T-lymphocytes exhibit two different modes of motility - upstream or downstream - under fluid flow that depends on ligand composition and the shear rate. ..
  23. Wang Y, Kong X, Wang M, Li J, Chen W, Jiang D. Luteolin Partially Inhibits LFA-1 Expression in Neutrophils Through the ERK Pathway. Inflammation. 2019;42:365-374 pubmed publisher
    ..To conclude, the p38 MAPK, ERK, PI3K, and JAK pathways are involved in the regulation of LFA-1 expression in neutrophils, and luteolin partially inhibits LFA-1 expression by increasing cAMP levels and suppressing ERK phosphorylation. ..
  24. Wang Y, Yang H, Hu Q, Hou Y, Luo H, Liu L. [Effects of continuous sedation with propofol on peripheral blood mononuclear cell and intercellular adhesion molecule in beagles with combined burn-blast injuries]. Zhonghua Yi Xue Za Zhi. 2014;94:1573-6 pubmed
    ..09 ± 0.15)% vs (1.64 ± 0.10)%) (P < 0.01). Propofol may improve the immune function after combined burn-blast injuries through suppressing an excessive release of ICAM-1 and PBMC apoptosis in a concentration-dependent manner. ..
  25. Giraldo J, Molano R, Rengifo H, Fotino C, Gattás Asfura K, Pileggi A, et al. The impact of cell surface PEGylation and short-course immunotherapy on islet graft survival in an allogeneic murine model. Acta Biomater. 2017;49:272-283 pubmed publisher
  26. Lishko V, Kudryk B, Yakubenko V, Yee V, Ugarova T. Regulated unmasking of the cryptic binding site for integrin alpha M beta 2 in the gamma C-domain of fibrinogen. Biochemistry. 2002;41:12942-51 pubmed
    Fibrinogen is a ligand for leukocyte integrin alpha(M)beta2 (CD11b/CD18, Mac-1) and mediates adhesion and migration of leukocytes during the immune-inflammatory responses...
  27. Solomon E, Palmer R, Hing S, Law S. Regional localization of CD18, the beta-subunit of the cell surface adhesion molecule LFA-1, on human chromosome 21 by in situ hybridization. Ann Hum Genet. 1988;52:123-8 pubmed
    ..The gene coding for the beta-subunit of the cell surface adhesion glycoprotein LFA-1 has been localized to the tip of the long arm of chromosome 21 at 21q22.1-qter. ..
  28. Makinoshima H, Takita M, Saruwatari K, Umemura S, Obata Y, Ishii G, et al. Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma. J Biol Chem. 2015;290:17495-504 pubmed publisher
    ..and PI3K/AKT/mammalian target of rapamycin (mTOR) pathways on metabolic alteration in lung adenocarcinoma (LAD) cell lines with activating EGFR mutations...
  29. Saucier C, Karthickeyan P, Ranjithkumar V, Lima E, Dos Reis G, de Brum I. Efficient removal of amoxicillin and paracetamol from aqueous solutions using magnetic activated carbon. Environ Sci Pollut Res Int. 2017;24:5918-5932 pubmed publisher
    ..00 and 96.77% for MAC-1 and MAC-2, respectively, of a mixture of nine pharmaceuticals with high concentrations of sugars, organic components and saline concentrations. ..
  30. Dehnadi A, Benedict Cosimi A, Neal Smith R, Li X, Alonso J, Means T, et al. Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys. Nat Commun. 2017;8:13899 pubmed publisher
    ..Here we demonstrate that inhibition of the archetypal innate immune receptor CD11b/CD18 prevents progression of AKI to CKD in cynomolgus monkeys...
  31. Agrawal H, Molossi S, Alam M, Sexson Tejtel S, Mery C, McKenzie E, et al. Anomalous Coronary Arteries and Myocardial Bridges: Risk Stratification in Children Using Novel Cardiac Catheterization Techniques. Pediatr Cardiol. 2017;38:624-630 pubmed publisher
    ..Four patients had myocardial bridges of the left anterior descending (LAD) coronary artery, 2 patients had isolated AAOCA, and 2 patients had an anomalous left coronary artery (LCA) with an ..
  32. Yamabe H, Kaikita K, Matsumura T, Iwasa A, Koyama J, Uemura T, et al. Study on the Effect of Irbesartan on Atrial Fibrillation Recurrence in Kumamoto: Atrial Fibrillation Suppression Trial (SILK study). J Cardiol. 2018;71:129-134 pubmed publisher
    ..the interval from the procedure to the first AF/AT recurrence, cardiovascular events, left atrial diameter (LAD), left ventricular ejection fraction (LVEF), and changes in the biomarkers [brain natriuretic polypeptide (BNP), ..
  33. Fagerholm S, Morrice N, Gahmberg C, Cohen P. Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes. J Biol Chem. 2002;277:1728-38 pubmed
    The CD11/CD18 (beta(2)) integrins are leukocyte-specific adhesion receptors, and their ability to bind ligands on other cells can be activated by extracellular stimuli...
  34. Calderwood D, Fujioka Y, de Pereda J, García Alvarez B, Nakamoto T, Margolis B, et al. Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A. 2003;100:2272-7 pubmed
    ..These data establish that short integrin beta tails interact with a large number of PTB domain-containing proteins through a structurally conserved mechanism. ..
  35. Becker Schiebe M, Stockhammer M, Hoffmann W, Wetzel F, Franz H. Does mean heart dose sufficiently reflect coronary artery exposure in left-sided breast cancer radiotherapy? : Influence of respiratory gating. Strahlenther Onkol. 2016;192:624-31 pubmed publisher
    ..The mean dose to the heart (Dmean heart) was reduced from 2.7 (0.8-5.2) Gy to 2.4 (1.1-4.6) Gy, the Dmean LAD (left anterior descending artery) decreased from 11.1 (1.3-28.6) Gy to 9.3 (2.2-19.9) Gy with gated RT (p = 0.04)...
  36. Uzonyi B, Mácsik Valent B, Lukácsi S, Kiss R, Török K, Kremlitzka M, et al. Functional studies of chronic lymphocytic leukemia B cells expressing β2-integrin type complement receptors CR3 and CR4. Immunol Lett. 2017;189:73-81 pubmed publisher
    The expression and role of CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in B cells are not yet explored in contrast to myeloid cells, where these β2-integrin type receptors are known to participate in various cellular functions, ..
  37. Barth R, Kellough D, Allenby P, Blower L, Hammond S, Allenby G, et al. Assessment of atherosclerotic luminal narrowing of coronary arteries based on morphometrically generated visual guides. Cardiovasc Pathol. 2017;29:53-60 pubmed publisher
    ..created digital whole-slide images of 20 representative microscopic cross sections of the left anterior descending (LAD) coronary artery, stained with either hematoxylin and eosin (H&E) or Movat's pentachrome stain...
  38. Dong X, Bai C, Nao J. Influential factors and clinical significance of fluid-attenuated inversion recovery vascular hyperintensities in transient ischemic attacks of carotid arterial system. Neuroradiology. 2017;59:1093-1099 pubmed publisher
    ..9), FVH was confirmed in 61 patients (39.6%). In logistic regression analysis, intracranial large-artery disease (LAD) (OR = 2.39, 95% CI 1.16-4.92; p = 0.018) and prior stroke (OR = 3.33, 95% CI 1.48-7...
  39. Novak J, Fabrik I, Linhartova I, Link M, Cerny O, Stulik J, et al. Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells. Sci Rep. 2017;7:16298 pubmed publisher
    ..pertussis subverts immune functions of host myeloid cells expressing the ?M?2 integrin (CD11b/CD18, CR3 or Mac-1)...
  40. Kim C, Lee K, Lee C, Kim Y, Han S, Shim Y, et al. Aggregation of beta2 integrins activates human neutrophils through the IkappaB/NF-kappaB pathway. J Leukoc Biol. 2004;75:286-92 pubmed
    ..Such neutrophil adherence is mediated predominantly through beta(2) integrins (CD11/CD18) on its surface...
  41. Pisarenko O, Shulzhenko V, Studneva I, Serebryakova L, Pelogeykina Y, Veselova O. Signaling pathways of a structural analogue of apelin-12 involved in myocardial protection against ischemia/reperfusion injury. Peptides. 2015;73:67-76 pubmed publisher
    ..Isolated perfused working rat hearts subjected to global ischemia and anaesthetized rats in vivo exposed to LAD coronary artery occlusion were used...
  42. Dutey Magni P, Moon G. The spatial structure of chronic morbidity: evidence from UK census returns. Int J Health Geogr. 2016;15:30 pubmed publisher
    ..Once the most important characteristics observable at the LAD-level are taken into account, substantial spatial autocorrelation remains which can be modelled explicitly to ..
  43. Urlaub D, Höfer K, Müller M, Watzl C. LFA-1 Activation in NK Cells and Their Subsets: Influence of Receptors, Maturation, and Cytokine Stimulation. J Immunol. 2017;198:1944-1951 pubmed publisher
    ..Our data suggest that regulation of LFA-1 is one reason for the different activity of NK cells during differentiation. ..
  44. Chiastra C, Gallo D, Tasso P, Iannaccone F, Migliavacca F, Wentzel J, et al. Healthy and diseased coronary bifurcation geometries influence near-wall and intravascular flow: A computational exploration of the hemodynamic risk. J Biomech. 2017;58:79-88 pubmed publisher
    ..idealized models of both stenosed and unstenosed bifurcations, representing the left anterior descending (LAD) coronary artery with its diagonal branch...
  45. Hossain M, Omran E, Xu N, Liu L. The Specific Mitogen- and Stress-Activated Protein Kinase MSK1 Inhibitor SB-747651A Modulates Chemokine-Induced Neutrophil Recruitment. Int J Mol Sci. 2017;18: pubmed publisher
    ..Collectively, our data suggest that inhibition of MSK1 by SB-747651A treatment affects CXCL2-induced neutrophil recruitment by modulating various steps of the recruitment cascade in vivo. ..
  46. Swaim C, Scott A, Canadeo L, Huibregtse J. Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor. Mol Cell. 2017;68:581-590.e5 pubmed publisher
    ..identified residues critical for ISG15 signaling, and identified the cell surface receptor as LFA-1 (CD11a/CD18; αLβ2 integrin)...
  47. Welzenbach K, Hommel U, Weitz Schmidt G. Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition. J Biol Chem. 2002;277:10590-8 pubmed
    ..Differentially targeting the binding sites of the inhibitors, the L-site and the I-like domain, may open new avenues for highly specific therapeutic intervention in diseases where integrins play a pathophysiological role. ..
  48. Kong T, Eltzschig H, Karhausen J, Colgan S, Shelley C. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. Proc Natl Acad Sci U S A. 2004;101:10440-5 pubmed
    ..Subsequent studies identified a binding site for hypoxia-inducible factor 1 (HIF-1) in the CD18 gene. This gene encodes the subunit common to all four known types of beta2 integrin heterodimer...
  49. Chua G, Tang X, Amalraj M, Tan S, Bhattacharjya S. Structures and interaction analyses of integrin ?M?2 cytoplasmic tails. J Biol Chem. 2011;286:43842-54 pubmed publisher
    ..2±0.6 and ?4.4±0.7 ?m, respectively. Docked structures of tail-tail complexes delineated that the ?M/?2 interface at the cytosolic region could be sustained by a network of polar interactions, ionic interactions, and/or hydrogen bonds. ..
  50. Oksala N, Pärssinen J, Seppälä I, Klopp N, Illig T, Laaksonen R, et al. Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds. Atherosclerosis. 2015;242:145-54 pubmed publisher
    ..Simultaneous upregulation of ITGB2 suggests a synergistic effect on leukocyte adherence and transmigration into the vessel wall. ..
  51. Vignesh P, Rawat A, Singh S. An Update on the Use of Immunomodulators in Primary Immunodeficiencies. Clin Rev Allergy Immunol. 2017;52:287-303 pubmed publisher
    ..Anti-IL17 agents have show efficacy in animal models of leukocyte adhesion defect (LAD) and ALPS...
  52. Chen J, Xu Y, Tao L, Pan Y, Zhang K, Wang R, et al. MiRNA-26a Contributes to the Acquisition of Malignant Behaviors of Doctaxel-Resistant Lung Adenocarcinoma Cells through Targeting EZH2. Cell Physiol Biochem. 2017;41:583-597 pubmed publisher
    ..has been applied in improving the survival and prognosis of patients with advanced lung adenocarcinoma (LAD). However, chemoresistance remains a major impediment to clinical application of this agent...
  53. Jeong J, Uong T, Chung W, Nam T, Ahn S, Song J, et al. Effect of irradiation-induced intercellular adhesion molecule-1 expression on natural killer cell-mediated cytotoxicity toward human cancer cells. Cytotherapy. 2018;20:715-727 pubmed publisher
    ..Irradiation upregulates ICAM-1 expression on the surface of human cancer cells and enhances activated NK cell-mediated cytotoxicity. Therefore, irradiation combined with NK cell therapy may improve the antitumor effects of NK cells. ..
  54. Van der Vieren M, Le Trong H, Wood C, Moore P, St John T, Staunton D, et al. A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3. Immunity. 1995;3:683-90 pubmed
    The leukocyte-restricted beta 2 (CD18) integrins mediate cell adhesion in a variety of events essential for normal immune function...
  55. Chakrabarti S, Patel K. The atypical zeta (zeta) isoform of protein kinase C regulates CD11b/CD18 activation in human neutrophils. Microcirculation. 2008;15:555-67 pubmed publisher examine the role of protein kinase C zeta (PKCzeta) in interleukin (IL)-8-mediated activation of Mac-1 (CD11b/CD18) in human neutrophils...
  56. Shanthalingam S, Tibary A, Beever J, Kasinathan P, Brown W, Srikumaran S. Precise gene editing paves the way for derivation of Mannheimia haemolytica leukotoxin-resistant cattle. Proc Natl Acad Sci U S A. 2016;113:13186-13190 pubmed
    ..Previously, we reported that, contrary to the paradigm, the signal peptide of ruminant CD18, the β subunit of β2 integrins, is not cleaved and hence remains intact on mature CD18 molecules ..
  57. Johnson D, Wayt J, Wilson J, Donaldson J. Arf6 and Rab22 mediate T cell conjugate formation by regulating clathrin-independent endosomal membrane trafficking. J Cell Sci. 2017;130:2405-2415 pubmed publisher
    ..These observations support a role for CIE, Arf6 and Rab22 in conjugate formation between T cells and APCs. ..
  58. Ding W, Shimada H, Li L, Mittal R, Zhang X, Shudo K, et al. Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model. Blood. 2013;121:996-1007 pubmed publisher
    ..accompanied both better granule maturation and greater coexpression of CD66 antigen with the integrin ?2 subunit CD18. Consistently, anti-CD18 antibody neutralized Am80-induced bactericidal activities of AINs...
  59. Hajishengallis G, Moutsopoulos N. Role of bacteria in leukocyte adhesion deficiency-associated periodontitis. Microb Pathog. 2016;94:21-6 pubmed publisher
    Leukocyte adhesion deficiency Type I (LAD-I)-associated periodontitis is an aggressive form of inflammatory bone loss that has been historically attributed to lack of neutrophil surveillance of the periodontal infection...
  60. Qayyum A, Qayyum F, Larsson H, Kjaer A, Hasbak P, Vejlstrup N, et al. Comparison of rest and adenosine stress quantitative and semi-quantitative myocardial perfusion using magnetic resonance in patients with ischemic heart disease. Clin Imaging. 2017;41:149-156 pubmed publisher
    ..MP was able to distinguish between ischemic and non-ischemic territories at rest (left anterior descending artery (LAD): 103.1±11.3mL/100g/min vs. 206.3±98.5mL/100g/min; p=0.001, right coronary artery (RCA): 124.1±45...
  61. Li C, Sun L, Jiang R, Wang P, Xue H, Zhan Y, et al. Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma. Pathol Res Pract. 2017;213:1251-1256 pubmed publisher
    Our study aimed to investigate the biological role of FOXP3 expression in human lung adenocarcinoma (LAD) tissues and evaluate its involvement in cell proliferation and chemosensitivity to cisplatin in LAD cells...
  62. Tardif M, Gilbert C, Thibault S, Fortin J, Tremblay M. LFA-1 antagonists as agents limiting human immunodeficiency virus type 1 infection and transmission and potentiating the effect of the fusion inhibitor T-20. Antimicrob Agents Chemother. 2009;53:4656-66 pubmed publisher
    ..Antiadhesion therapy could be considered a complementary strategy targeting cellular functions essential for HIV-1 spreading and against which the combined therapy currently used displays a limited efficacy. ..
  63. Guo C, Jiang X, Zeng X, Wang H, Li H, DU F, et al. Soluble receptor for advanced glycation end-products protects against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system. Free Radic Biol Med. 2016;94:17-26 pubmed publisher
    ..p.) or saline were performed to ligate left anterior descending coronary artery (LAD) as an in vivo model...
  64. Elabbassi W, Al Nooryani A. Skirt followed by trouser stenting technique: True anatomical preservation of coronary Y-shaped bifurcation lesions while using "vanishing" bioresorbable scaffolds: A report of two cases. Cardiovasc Revasc Med. 2017;18:281-286 pubmed publisher
    ..Coronary angiography showed stenosis involving a Y-shaped bifurcation of proximal to mid LAD and diagonal. The lesion was wired using two 0...
  65. Abualnaja S, Alrammah H, Alsaif B, Almulla M, Alzahrani B. A Case of Subacute Bioresorbable Vascular Scaffold Thrombosis, What was Wrong?. Am J Case Rep. 2017;18:1343-1346 pubmed
    ..on diagnostic coronary angiography he had 75% and 70% stenosis in mid and distal left anterior descending artery (LAD) respectively, PCI with BVS implantation was done...
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