Gene Symbol: CD164
Description: CD164 molecule
Alias: DFNA66, MGC-24, MGC-24v, MUC-24, endolyn, sialomucin core protein 24, CD164 antigen, sialomucin, multi-glycosylated core protein 24
Species: human
Products:     CD164

Top Publications

  1. Zannettino A, Buhring H, Niutta S, Watt S, Benton M, Simmons P. The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. Blood. 1998;92:2613-28 pubmed
    ..This molecule was clustered as CD164 at the recent workshop on human leukocyte differentiation antigens...
  2. Masuzawa Y, Miyauchi T, Hamanoue M, Ando S, Yoshida J, Takao S, et al. A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression. J Biochem. 1992;112:609-15 pubmed
    ..MGC-24 mRNA was intensely expressed in normal tissues of the colon, small intestine and thyroid, and in some nude mouse-transplanted colorectal and pancreatic adenocarcinomas. ..
  3. Zhou G, Zhang Y, Ferguson D, Chen S, Rasmuson Lestander A, Campbell F, et al. The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation. J Cell Biochem. 2006;99:1380-96 pubmed
    b>Endolyn (CD164) is a sialomucin that regulates the proliferation, adhesion, and migration of human haematopoietic stem and progenitor cells...
  4. Tang J, Zhang L, She X, Zhou G, Yu F, Xiang J, et al. Inhibiting CD164 expression in colon cancer cell line HCT116 leads to reduced cancer cell proliferation, mobility, and metastasis in vitro and in vivo. Cancer Invest. 2012;30:380-9 pubmed publisher
    CD164 (Endolyn) is a sialomucin, which has been found to play roles in regulating proliferation, adhesion, and differentiation of hematopoietic stem cells. Possible association of CD164 with solid cancer development remains unknown...
  5. Watt S, Buhring H, Rappold I, Chan J, Lee Prudhoe J, Jones T, et al. CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21. Blood. 1998;92:849-66 pubmed
    b>CD164 is a novel 80- to 90-kD mucin-like molecule expressed by human CD34(+) hematopoietic progenitor cells...
  6. Havens A, Jung Y, Sun Y, Wang J, Shah R, Buhring H, et al. The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis. BMC Cancer. 2006;6:195 pubmed
    ..While screening prostate cancers for CXCL12-responsive adhesion molecules, we identified CD164 (MGC-24) as a potential regulator of homing...
  7. Forde S, Tye B, Newey S, Roubelakis M, Smythe J, McGuckin C, et al. Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells. Blood. 2007;109:1825-33 pubmed
    ..Here, we provide evidence that the sialomucin endolyn (CD164), an adhesion receptor that regulates the adhesion of CD34+ cells to bone marrow stroma and the ..
  8. Doyonnas R, Yi Hsin Chan J, Butler L, Rappold I, Lee Prudhoe J, Zannettino A, et al. CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor. J Immunol. 2000;165:840-51 pubmed
    The novel sialomucin, CD164, functions as both an adhesion receptor on human CD34+ cell subsets in bone marrow and as a potent negative regulator of CD34+ hemopoietic progenitor cell proliferation...
  9. Kurosawa N, Kanemitsu Y, Matsui T, Shimada K, Ishihama H, Muramatsu T. Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164. Eur J Biochem. 1999;265:466-72 pubmed
    ..That the promoter resembles that of house-keeping genes is consistent with the broad expression of mouse MGC-24 mRNA. ..

More Information


  1. Chan J, Lee Prudhoe J, Jorgensen B, Ihrke G, Doyonnas R, Zannettino A, et al. Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn. J Biol Chem. 2001;276:2139-52 pubmed
    ..This study provides additional evidence that human CD164(E1-6) represents the ortholog of murine MGC-24v and rat endolyn. Comparative analysis of murine MGC-24v/CD164(E1-6) with human CD164(E1-6) revealed two potential splice variants ..
  2. Tang J, Luo Z, Zhou G, Song C, Yu F, Xiang J, et al. Cis-regulatory functions of overlapping HIF-1alpha/E-box/AP-1-like sequences of CD164. BMC Mol Biol. 2011;12:44 pubmed publisher
    CD164 (also known as MGC-24v or endolyn) is a sialomucin which has been suggested to participate in regulating the proliferation, cell adhesion and differentiation of hematopoietic stem and progenitor cells...
  3. Ebrahimi Dastgurdi M, Ejeian F, Nematollahi M, Motaghi A, Nasr Esfahani M. Comparison of two digestion strategies on characteristics and differentiation potential of human dental pulp stem cells. Arch Oral Biol. 2018;93:74-79 pubmed publisher
    ..05). On the other hand, more STRO-1+/CD164-DPSCs were found in the collagenase alone group with higher adipogenic potential...
  4. Corvan S, Agnew L, Andronicos N. Trichostrongylus colubriformis induces IgE-independent CD13, CD164 and CD203c mediated activation of basophils in an in vitro intestinal epithelial cell co-culture model. Vet Parasitol. 2015;207:285-96 pubmed publisher
    ..Cell surface expression of CD164, CD107a and CD13 antigens on gated CD203(+) cells were determined and qRT-PCR was used to examine gene expression ..
  5. Mo D, Costa S, Ihrke G, Youker R, Pastor Soler N, Hughey R, et al. Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism. Mol Biol Cell. 2012;23:3636-46 pubmed publisher
    The sialomucin endolyn is implicated in adhesion, migration, and differentiation of various cell types. Along rat kidney tubules, endolyn is variously localized to the apical surface and endosomal/lysosomal compartments...
  6. Ayala Lujan J, Vijayakumar V, Gong M, Smith R, Santiago A, Ruiz Perez F. Broad spectrum activity of a lectin-like bacterial serine protease family on human leukocytes. PLoS ONE. 2014;9:e107920 pubmed publisher
    ..Protease activity was seen in virtually all tested O-glycosylated proteins including CD34, CD55, CD164, TIM1, TIM3, TIM4 and C1-INH...
  7. Ulirsch J, Nandakumar S, Wang L, Giani F, Zhang X, Rogov P, et al. Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits. Cell. 2016;165:1530-1545 pubmed publisher
    ..endogenous enhancer activity across 3 MFVs that predominantly affect the transcription of SMIM1, RBM38, and CD164. Functional follow-up of RBM38 delineates a key role for this gene in the alternative splicing program occurring ..
  8. Cedeno Laurent F, Wysocka M, Obstfeld A, Novoa R, Vittorio C, Kim E, et al. Gain of CD26 expression on the malignant T-cells in relapsed erythrodermic leukemic mycosis fungoides. J Cutan Pathol. 2017;44:462-466 pubmed publisher
    ..Interestingly, quantitative expression of the sialomucin, CD164, mirrored her clinical picture, thus favoring its reliability as a novel biomarker in CTCL.
  9. Ozel Demiralp D, Haznedaroglu I, Akar N. Functional proteomic analysis of Ankaferd® Blood Stopper. Turk J Haematol. 2010;27:70-7 pubmed publisher
    ..that proteins resembling human peptides have been detected within Ankaferd®, including ATP synthase, mucin-16 (CD164 sialomucin-like 2 protein), coiled-coil domain containing 141 hypothetical protein LOC283638 isoform 1, ..
  10. Nicolay J, Felcht M, Schledzewski K, Goerdt S, Géraud C. Sézary syndrome: old enigmas, new targets. J Dtsch Dermatol Ges. 2016;14:256-64 pubmed publisher
    ..Despite their plasticity, SC express characteristic diagnostic marker proteins including CD158k, CD164, FcRL3, and PD-1 as well as skin-homing receptors such as CLA and CCR4...
  11. Wolanczyk Medrala A, Barg W, Liebhart J, Panaszek B, Nadobna G, Litwa M, et al. Validation of basophil CD164 upregulation for pollen allergy diagnosis. Arch Immunol Ther Exp (Warsz). 2010;58:459-65 pubmed publisher
    The aim of the study was to evaluate the sensitivity and specificity of allergen-induced basophil CD164 upregulation in patients with seasonal allergic rhinitis caused by allergy to grass pollens...
  12. Nyegaard M, Rendtorff N, Nielsen M, Corydon T, Demontis D, Starnawska A, et al. A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment. PLoS Genet. 2015;11:e1005386 pubmed publisher
    ..R192*) in CD164. This gene encodes a 197 amino acid transmembrane sialomucin (known as endolyn, MUC-24 or CD164), which is widely expressed and involved in cell adhesion and migration...
  13. Huang A, Chen M, Huang S, Kao C, Lai H, Chan J. CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1?/CXCR4 axis. Mol Cancer. 2013;12:115 pubmed publisher
    CD164 (endolyn), a sialomucin, has been reported to play a role in the proliferation, adhesion, and differentiation of hematopoietic stem cells. The potential association of CD164 with tumorigenicity remains unclear...
  14. Shi J, Lu D, Huang X, Tan W. miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164. Int J Mol Med. 2014;34:237-43 pubmed publisher
    ..Secondly, we predicted that miR-219 targets the 3' untranslated region (3'UTR) of CD164 and orthodenticle homeobox 2 (OTX2) and then confirmed that it significantly downregulated the protein expression ..
  15. Chen J, Chen W, Chan J, Chen Y, Peng Y, Cheng M, et al. Overexpression of CD164 in oral cavity squamous cell carcinoma predicts a favourable prognosis. Oncol Lett. 2017;14:6103-6108 pubmed publisher
    ..postoperative chemoradiotherapy although the specimens were not exposed to radiation or chemotherapy prior to anti-CD164 antibody immunohistochemical staining...
  16. Guenova E, Ignatova D, Chang Y, Contassot E, Mehra T, Saulite I, et al. Expression of CD164 on Malignant T cells in Sézary Syndrome. Acta Derm Venereol. 2016;96:464-7 pubmed publisher
    ..In a cohort of patients with Sézary syndrome, CD164 expression on total CD4+ lymphocytes was significantly upregulated compared with healthy controls...
  17. Benoit B, Jariwala N, O Connor G, Oetjen L, Whelan T, Werth A, et al. CD164 identifies CD4+ T cells highly expressing genes associated with malignancy in Sézary syndrome: the Sézary signature genes, FCRL3, Tox, and miR-214. Arch Dermatol Res. 2017;309:11-19 pubmed publisher
    ..We recently demonstrated the high expression of CD164 on CD4+ T cells from Sézary syndrome patients with a wide range of circulating tumor burdens...
  18. Chen Z, Tang H, Qayyum R, Schick U, Nalls M, Handsaker R, et al. Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network. Hum Mol Genet. 2013;22:2529-38 pubmed publisher
    ..of association of erythrocyte traits with several loci previously reported in Europeans and/or Asians, including CD164 and HBS1L-MYB...
  19. Seiki T, Naito M, Hishida A, Takagi S, Matsunaga T, Sasakabe T, et al. Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population. Gene. 2018;642:172-177 pubmed publisher
    ..We replicated the association of ABO rs495828, PDGFRA-KIT rs218237, USP49-MED20-BSYL-CCND3 rs3218097, C6orf182-CD164 rs11966072, TERT rs2736100, and TMPRSS6 rs5756504 with erythrocyte traits in our independent Japanese population...
  20. Lin J, Xu K, Wei J, Heimberger A, Roth J, Ji L. MicroRNA-124 suppresses tumor cell proliferation and invasion by targeting CD164 signaling pathway in non-small cell lung cancer. J Gene Ther. 2016;2: pubmed
    ..Two endogenous miR-124 targeting sites in the 3'UTR of CD164 mRNA are identified by a stem-loop-array reverse transcription PCR (SLA-RT-PCR) assay in H1299 cells under ..
  21. Hennersdorf F, Florian S, Jakob A, Baumgärtner K, Sonneck K, Nordheim A, et al. Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation. Cell Res. 2005;15:325-35 pubmed
    ..These include antibodies against CD164 (WS-80160, clone N6B6 and WS-80162, clone 67D2), as well as two reagents with previously unknown specificities ..
  22. Zannettino A. CD164. J Biol Regul Homeost Agents. 2001;15:394-6 pubmed
  23. Wysocka M, Kossenkov A, Benoit B, Troxel A, Singer E, Schaffer A, et al. CD164 and FCRL3 are highly expressed on CD4+CD26- T cells in Sézary syndrome patients. J Invest Dermatol. 2014;134:229-236 pubmed publisher
    ..Results showed significantly increased levels of mRNA for CD164, a sialomucin found on human CD34+ hematopoietic stem cells, and FCRL3, a molecule present on a subset of human ..
  24. McLaren P, Gawanbacht A, Pyndiah N, Krapp C, Hotter D, Kluge S, et al. Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. Retrovirology. 2015;12:41 pubmed publisher
    ..Five factors (APOL1, APOL6, CD164, TNFRSF10A, TNFRSF10D) suppressed infectious HIV-1 production in transfected 293T cells by >90% and six ..
  25. Tu M, Cai L, Zheng W, Su Z, Chen Y, Qi S. CD164 regulates proliferation and apoptosis by targeting PTEN in human glioma. Mol Med Rep. 2017;15:1713-1721 pubmed publisher
    Cluster of differentiation 164 (CD164), a sialomucin, has been demonstrated to be involved in the regulation of proliferation, apoptosis, adhesion and differentiation in multiple cancers...