CD163

Summary

Gene Symbol: CD163
Description: CD163 molecule
Alias: M130, MM130, SCARI1, scavenger receptor cysteine-rich type 1 protein M130, hemoglobin scavenger receptor, macrophage-associated antigen
Species: human
Products:     CD163

Top Publications

  1. Jensen T, Schmidt H, Møller H, Høyer M, Maniecki M, Sjoegren P, et al. Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma. J Clin Oncol. 2009;27:3330-7 pubmed publisher
    To evaluate the prognostic role of soluble CD163 (sCD163) in serum and macrophage infiltration in primary melanomas from patients with American Joint Committee on Cancer (AJCC) stage I/II melanoma...
  2. Tan K, Scott D, Hong F, Kahl B, Fisher R, Bartlett N, et al. Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial. Blood. 2012;120:3280-7 pubmed publisher
    ..Immunohistochemistry for CD68 and CD163, and in situ hybridization for EBV-encoded RNA were performed...
  3. Matsushita N, Kashiwagi M, Wait R, Nagayoshi R, Nakamura M, Matsuda T, et al. Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3. Clin Exp Immunol. 2002;130:156-61 pubmed
    ..sera and fluids from rheumatoid arthritis (RA) patients and elucidate the mechanism that regulates the shedding of CD163. Levels of soluble CD163 in sera and fluids from RA patients were examined by a sandwich enzyme immunoassay and ..
  4. Levy A, Purushothaman K, Levy N, Purushothaman M, Strauss M, Asleh R, et al. Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability. Circ Res. 2007;101:106-10 pubmed
    ..The macrophage hemoglobin scavenging receptor CD163 plays an essential role in the clearance of hemoglobin released from lysed red blood cells after intraplaque ..
  5. Komohara Y, Hirahara J, Horikawa T, Kawamura K, Kiyota E, Sakashita N, et al. AM-3K, an anti-macrophage antibody, recognizes CD163, a molecule associated with an anti-inflammatory macrophage phenotype. J Histochem Cytochem. 2006;54:763-71 pubmed
    b>CD163 is a member of the scavenger receptor cysteine-rich superfamily restricted to the monocyte/macrophage lineage and is thought to be a useful marker for anti-inflammatory or alternatively activated macrophages...
  6. Møller H. Soluble CD163. Scand J Clin Lab Invest. 2012;72:1-13 pubmed publisher
    b>CD163 is an endocytic receptor for haptoglobin-hemoglobin complexes and is expressed solely on macrophages and monocytes...
  7. Harris J, Jain S, Ren Q, Zarineh A, Liu C, Ibrahim S. CD163 versus CD68 in tumor associated macrophages of classical Hodgkin lymphoma. Diagn Pathol. 2012;7:12 pubmed publisher
    ..mostly nodular sclerosis subtype, in which the immunohistochemical stains for the histiocytic markers CD68 and CD163 were performed...
  8. Sulahian T, Hintz K, Wardwell K, Guyre P. Development of an ELISA to measure soluble CD163 in biological fluids. J Immunol Methods. 2001;252:25-31 pubmed
    b>CD163 is a monocyte/macrophage restricted transmembrane glycoprotein and a member of the scavenger receptor cysteine-rich (SRCR) family of proteins. SRCR proteins are typically associated with the immune system...
  9. Shabo I, Olsson H, Sun X, Svanvik J. Expression of the macrophage antigen CD163 in rectal cancer cells is associated with early local recurrence and reduced survival time. Int J Cancer. 2009;125:1826-31 pubmed publisher
    Expression of the macrophage antigen CD163 in breast cancer cells is recently shown to be related to early distant recurrence and shortened survival...

More Information

Publications77

  1. Kjærgaard A, Rødgaard Hansen S, Dige A, Krog J, Møller H, Tønnesen E. Monocyte expression and soluble levels of the haemoglobin receptor (CD163/sCD163) and the mannose receptor (MR/sMR) in septic and critically ill non-septic ICU patients. PLoS ONE. 2014;9:e92331 pubmed publisher
    ..Following activation of macrophages and monocytes, the haptoglobin-haemoglobin receptor (CD163) and the mannose receptor (MR) are shed into the circulation (sCD163 and sMR)...
  2. Parkner T, Sørensen L, Nielsen A, Fischer C, Bibby B, Nielsen S, et al. Soluble CD163: a biomarker linking macrophages and insulin resistance. Diabetologia. 2012;55:1856-62 pubmed publisher
    Soluble CD163 (sCD163) was recently identified as a strong risk marker for developing type 2 diabetes. We hypothesised that sCD163 independently associates with insulin resistance...
  3. Urbonaviciene G, Martin Ventura J, Lindholt J, Urbonavicius S, Moreno J, Egido J, et al. Impact of soluble TWEAK and CD163/TWEAK ratio on long-term cardiovascular mortality in patients with peripheral arterial disease. Atherosclerosis. 2011;219:892-9 pubmed publisher
    ..72-0.86) vs. 0.84 (0.78-0.90), p = 0.019). Decreased sTWEAK concentration, and increased sCD163/sTWEAK ratio were significantly and independently associated with long-term cardiovascular mortality in patients with lower-extremity PAD. ..
  4. Feng L, Zhou X, Su L, Feng D, Jia Y, Xie L. Clinical significance of soluble hemoglobin scavenger receptor CD163 (sCD163) in sepsis, a prospective study. PLoS ONE. 2012;7:e38400 pubmed publisher
    We investigated serum soluble CD163 (sCD163) levels for use in the diagnosis, severity assessment, and prognosis of sepsis in the critical ill patients and compared sCD163 with other infection-related variables...
  5. Ohri C, Shikotra A, Green R, Waller D, Bradding P. The tissue microlocalisation and cellular expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 is correlated to clinical outcome in NSCLC. PLoS ONE. 2011;6:e21874 pubmed publisher
    ..associated with either a cytotoxic M1 phenotype (HLA-DR, iNOS, and MRP 8/14), or a non-cytotoxic M2 phenotype (CD163 and VEGF) were identified...
  6. Buechler C, Ritter M, Orso E, Langmann T, Klucken J, Schmitz G. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. J Leukoc Biol. 2000;67:97-103 pubmed
    b>CD163, also referred to as M130, a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage...
  7. Ye H, Wang L, Zhao J, Wang K. Increased CD163 expression is associated with acute-on-chronic hepatitis B liver failure. World J Gastroenterol. 2013;19:2818-25 pubmed publisher
    To assess CD163 expression in plasma and peripheral blood and analyze its association with disease in acute-on-chronic hepatitis B liver failure (ACHBLF) patients...
  8. Moreno J, Dejouvencel T, Labreuche J, Smadja D, Dussiot M, Martin Ventura J, et al. Peripheral artery disease is associated with a high CD163/TWEAK plasma ratio. Arterioscler Thromb Vasc Biol. 2010;30:1253-62 pubmed publisher
    In addition to its role in the clearance of haptoglobin-hemoglobin (Hp-Hb) complexes, CD163 is a macrophage scavenger receptor for tumor necrosis factor-like weak inducer of apoptosis (TWEAK)...
  9. Law S, Micklem K, Shaw J, Zhang X, Dong Y, Willis A, et al. A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. Eur J Immunol. 1993;23:2320-5 pubmed
    ..and SM4 define a human macrophage-associated antigen with a relative molecular mass of 130,000 which we designate M130. The protein was purified by immunoaffinity chromatography and an N-terminal and three internal amino acid ..
  10. Ritter M, Buechler C, Kapinsky M, Schmitz G. Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. Eur J Immunol. 2001;31:999-1009 pubmed
    b>CD163 is a recently identified member of the scavenger receptor cysteine-rich superfamily, which is expressed on peripheral blood monocytes and most tissue macrophages and is thought to play an important role in the regulation of the ..
  11. Hintz K, Rassias A, Wardwell K, Moss M, Morganelli P, Pioli P, et al. Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163. J Leukoc Biol. 2002;72:711-7 pubmed
    b>CD163, a monocyte and macrophage-specific surface glycoprotein, which is increased by interleukin-10 and glucocorticoids, is a scavenger receptor for hemoglobin/haptoglobin complexes...
  12. Van den Heuvel M, Tensen C, van As J, van den Berg T, Fluitsma D, Dijkstra C, et al. Regulation of CD 163 on human macrophages: cross-linking of CD163 induces signaling and activation. J Leukoc Biol. 1999;66:858-66 pubmed
    b>CD163 is a member of the group B scavenger receptor cysteine-rich (SRCR) superfamily...
  13. Greisen S, Moller H, Stengaard Pedersen K, Hetland M, Hørslev Petersen K, Jørgensen A, et al. Soluble macrophage-derived CD163 is a marker of disease activity and progression in early rheumatoid arthritis. Clin Exp Rheumatol. 2011;29:689-92 pubmed
    To investigate the expression of the soluble form of the resident macrophage marker CD163 (sCD163) and its association with core parameters for disease activity, including radiographic progression in early rheumatoid arthritis (RA)...
  14. Frings W, Dreier J, Sorg C. Only the soluble form of the scavenger receptor CD163 acts inhibitory on phorbol ester-activated T-lymphocytes, whereas membrane-bound protein has no effect. FEBS Lett. 2002;526:93-6 pubmed
    The extracellular moiety of the hemoglobin/haptoglobin scavenger receptor CD163 (RM3/1 antigen) can be shed from monocytes and is a normal plasma component...
  15. Fonseca J, Edwards J, Blades S, Goulding N. Macrophage subpopulations in rheumatoid synovium: reduced CD163 expression in CD4+ T lymphocyte-rich microenvironments. Arthritis Rheum. 2002;46:1210-6 pubmed
    The cell surface glycoprotein CD163 is a member of the cysteine-rich scavenger receptor family, highly specific for leukocytes of the mononuclear phagocyte lineage...
  16. Schaer D, Schaer C, Buehler P, Boykins R, Schoedon G, Alayash A, et al. CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin. Blood. 2006;107:373-80 pubmed
    b>CD163 mediates the internalization of hemoglobin-haptoglobin (Hb-Hp) complexes by macrophages. Because Hp binding capacity is exhausted during severe hemolysis, an Hp-independent Hb-clearance pathway is presumed to exist...
  17. Graversen J, Madsen M, Moestrup S. CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma. Int J Biochem Cell Biol. 2002;34:309-14 pubmed
    b>CD163 is a highly expressed macrophage membrane protein belonging to the scavenger receptor cysteine rich (SRCR) domain family. The CD163 expression is induced by interleukin-6, interleukin-10 and glucocorticoids...
  18. Etzerodt A, Maniecki M, Møller K, Møller H, Moestrup S. Tumor necrosis factor ?-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163. J Leukoc Biol. 2010;88:1201-5 pubmed publisher
    b>CD163 is expressed specifically in the monocyte/macrophage lineage, where it mediates uptake of haptoglobin-hemoglobin complexes, leading to metabolism of the oxidative heme molecule...
  19. Zanni M, Burdo T, Makimura H, Williams K, Grinspoon S. Relationship between monocyte/macrophage activation marker soluble CD163 and insulin resistance in obese and normal-weight subjects. Clin Endocrinol (Oxf). 2012;77:385-90 pubmed publisher
    ..To investigate a marker of macrophage activation, soluble CD163 (sCD163), in relationship to insulin resistance and metabolic parameters in obese and normal-weight subjects...
  20. Yoon D, Koh Y, Kang H, Kim S, Park C, Lee S, et al. CD68 and CD163 as prognostic factors for Korean patients with Hodgkin lymphoma. Eur J Haematol. 2012;88:292-305 pubmed publisher
    ..In this work, we performed immunohistochemical analysis of CD163, as well as CD68, in 144 Korean patients with HL treated between November 1990 and December 2009 in a single ..
  21. Simoni J, Simoni G, Griswold J, Moeller J, Tsikouris J, Khanna A, et al. Role of free hemoglobin in 8-iso prostaglandin F2-alpha synthesis in chronic renal failure and its impact on CD163-Hb scavenger receptor and on coronary artery endothelium. ASAIO J. 2006;52:652-61 pubmed
    ..By monitoring correlations between Hb, haptoglobin (Hp), CD163-Hb-scavenger receptor, and 8-isoprostane that is known to induce CD163 shedding, we examined whether 8-isoprostane ..
  22. Fabriek B, van Bruggen R, Deng D, Ligtenberg A, Nazmi K, Schornagel K, et al. The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria. Blood. 2009;113:887-92 pubmed publisher
    The plasma membrane glycoprotein receptor CD163 is a member of the scavenger receptor cystein-rich (SRCR) superfamily class B that is highly expressed on resident tissue macrophages in vivo...
  23. Madsen M, Graversen J, Moestrup S. Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes. Redox Rep. 2001;6:386-8 pubmed
    The plasma protein haptoglobin and the endocytic hemoglobin receptor HbSR/CD163 are key molecules in the process of removing hemoglobin released from ruptured erythrocytes...
  24. Sulahian T, Pioli P, Wardwell K, Guyre P. Cross-linking of FcgammaR triggers shedding of the hemoglobin-haptoglobin scavenger receptor CD163. J Leukoc Biol. 2004;76:271-7 pubmed
    b>CD163, the hemoglobin (Hb)-haptoglobin scavenger receptor, is a monocyte/macrophage-restricted member of the scavenger receptor, cysteine-rich family of proteins...
  25. Moestrup S, Møller H. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Ann Med. 2004;36:347-54 pubmed
    CD163 is a hemoglobin scavenger receptor exclusively expressed in the monocyte-macrophage system...
  26. Moreno J, Munoz Garcia B, Martin Ventura J, Madrigal Matute J, Orbe J, Paramo J, et al. The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis. Atherosclerosis. 2009;207:103-10 pubmed publisher
    b>CD163 is a new potential scavenger receptor of Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) which elicits diverse biologic actions involved in atherosclerosis...
  27. Philippidis P, Mason J, Evans B, Nadra I, Taylor K, Haskard D, et al. Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery. Circ Res. 2004;94:119-26 pubmed
    The recently described hemoglobin scavenger receptor CD163 mediates the endocytosis of hemoglobin:haptoglobin (Hb:Hp) complexes and thereby counters Hb-induced oxidative tissue damage after hemolysis...
  28. Kristiansen M, Graversen J, Jacobsen C, Sonne O, Hoffman H, Law S, et al. Identification of the haemoglobin scavenger receptor. Nature. 2001;409:198-201 pubmed
    ..Here we report the identification of the acute phase-regulated and signal-inducing macrophage protein, CD163, as a receptor that scavenges haemoglobin by mediating endocytosis of haptoglobin-haemoglobin complexes...
  29. Hogger P, Sorg C. Soluble CD163 inhibits phorbol ester-induced lymphocyte proliferation. Biochem Biophys Res Commun. 2001;288:841-3 pubmed
    b>CD163 is a member of the scavenger receptor cysteine-rich family which is expressed exclusively on human monocytes and macrophages. Upon an inflammatory stimulus the protein is shed rapidly from the membranes' surface...
  30. Sugaya M, Miyagaki T, Ohmatsu H, Suga H, Kai H, Kamata M, et al. Association of the numbers of CD163(+) cells in lesional skin and serum levels of soluble CD163 with disease progression of cutaneous T cell lymphoma. J Dermatol Sci. 2012;68:45-51 pubmed publisher
    ..activated macrophages (M2 cells) produce IL-10 and express several receptors such as mannose receptor and CD163. Tumor-associated macrophages exhibit M2 phenotype, whose presence has been associated with poor prognosis in ..
  31. Lee C, Espinosa I, Vrijaldenhoven S, Subramanian S, Montgomery K, Zhu S, et al. Prognostic significance of macrophage infiltration in leiomyosarcomas. Clin Cancer Res. 2008;14:1423-30 pubmed publisher
    ..Gene expression profiling revealed high-level expression of several macrophage-associated genes such as CD163 and CD68 in a subset of leiomyosarcomas, indicating the presence of variable numbers of tumor-infiltrating ..
  32. Møller H, Grønbaek H, Schiødt F, Holland Fischer P, Schilsky M, Munoz S, et al. Soluble CD163 from activated macrophages predicts mortality in acute liver failure. J Hepatol. 2007;47:671-6 pubmed
    Soluble CD163 (sCD163) is a scavenger receptor shed in serum during inflammatory activation of macrophages. We investigated if sCD163 was increased and predicted outcome in acute liver failure (ALF)...
  33. Chihara T, Hashimoto M, Osman A, Hiyoshi Yoshidomi Y, Suzu I, Chutiwitoonchai N, et al. HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages. J Immunol. 2012;188:3620-7 pubmed publisher
    ..However, Nef reduced the expression of CD163 and phagocytosis, the characteristic markers of M2-M?, indicating that Nef drives an M2-like to M1-like phenotypic ..
  34. Mendonça V, Luz N, Santos N, Borges V, Goncalves M, Andrade B, et al. Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria. Infect Immun. 2012;80:1445-54 pubmed publisher
    ..homeostatic mechanisms, including the enzyme haptoglobin (Hp), which scavenges cell-free Hb, the monocyte receptor CD163, which binds to Hb-Hp complexes, and heme oxygenase-1 (HO-1), which degrades intracellular free heme...
  35. Bover L, Cardo Vila M, Kuniyasu A, Sun J, Rangel R, Takeya M, et al. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. J Immunol. 2007;178:8183-94 pubmed
    ..Cyclic peptides containing a consensus motif (WXDDG) bound to TWEAK specifically. These peptides were similar to CD163, a scavenger receptor cysteine-rich domain family member, restricted to the monocyte/macrophage lineage and ..
  36. Bauer P, Kashyap R, League S, Park J, Block D, Baumann N, et al. Diagnostic accuracy and clinical relevance of an inflammatory biomarker panel for sepsis in adult critically ill patients. Diagn Microbiol Infect Dis. 2016;84:175-80 pubmed publisher
    ..The 8-color flow cytometric biomarker panel included CD64, CD163, and HLA-DR. Index test results were compared with sepsis, using receiver operating characteristic curve analyses...
  37. Larsson K, Kock A, Idborg H, Arsenian Henriksson M, Martinsson T, Johnsen J, et al. COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset. Proc Natl Acad Sci U S A. 2015;112:8070-5 pubmed publisher
    ..showed high infiltration of tumor-promoting macrophages with high expression of the M2-polarization markers CD163 and CD206...
  38. Wisgrill L, Groschopf A, Herndl E, Sadeghi K, Spittler A, Berger A, et al. Reduced TNF-α response in preterm neonates is associated with impaired nonclassic monocyte function. J Leukoc Biol. 2016;100:607-12 pubmed publisher
    ..However, data from preterm infants are scarce. We analyzed constitutive monocyte TLR2, TLR4, CD163, and HLA-DR expression in preterm cord blood...
  39. Kasashima S, Kawashima A, Zen Y, Ozaki S, Kasashima F, Endo M, et al. Upregulated interleukins (IL-6, IL-10, and IL-13) in immunoglobulin G4-related aortic aneurysm patients. J Vasc Surg. 2018;67:1248-1262 pubmed publisher
    ..tissues were evaluated for cluster of differentiation (CD) 34 (in the endothelial cells and mesenchymal cells) and CD163 (by macrophages) expression using immunohistochemistry and in situ hybridization...
  40. Ha D, Carpenter L, Koutakis P, Swanson S, Zhu Z, Hanna M, et al. Transforming growth factor-beta 1 produced by vascular smooth muscle cells predicts fibrosis in the gastrocnemius of patients with peripheral artery disease. J Transl Med. 2016;14:39 pubmed publisher
    ..vascular smooth muscle cells (SMC) (high molecular weight caldesmon), fibroblasts (TE-7 antigen), macrophages (CD163), T cells (CD3) and endothelial cells (CD31)...
  41. Witherel C, Graney P, Freytes D, Weingarten M, Spiller K. Response of human macrophages to wound matrices in vitro. Wound Repair Regen. 2016;24:514-24 pubmed publisher
    ..PriMatrix caused up-regulation of TNFa (M1) and CD163 (M2c) and down-regulation of CCL22 and TIMP3 (both M2a). AlloMend caused up-regulation in CD163 (M2c)...
  42. Furukawa S, Moriyama M, Miyake K, Nakashima H, Tanaka A, Maehara T, et al. Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease. Sci Rep. 2017;7:42413 pubmed publisher
    ..Moreover, IL-33 and CD68+/CD163+ macrophages were mainly distributed around ectopic GCs in patients with IgG4-RD...
  43. Sonier B, Strom A, Wang G, Patrick C, Crookshank J, Mojibian M, et al. Antibodies from a patient with type 1 diabetes and celiac disease bind to macrophages that express the scavenger receptor CD163. Can J Gastroenterol. 2011;25:327-9 pubmed
    ..in the lamina propria of rat jejunum that co-localized mostly with a marker of resident, alternatively activated CD163-positive (CD163?) macrophages...
  44. Motwani M, Newson J, Kwong S, Richard Loendt A, Colas R, Dalli J, et al. Prolonged immune alteration following resolution of acute inflammation in humans. PLoS ONE. 2017;12:e0186964 pubmed publisher
    ..However, following a lag phase of about 4 days there was an increase in numbers of memory T cells and CD163+ macrophage at the post-resolution site up to day 17 as well as increased biosynthesis of cyclooxygenase-derived ..
  45. Maglietta A, Maglietta R, Staiano T, Bertoni R, Ancona N, Marra G, et al. The Immune Landscapes of Polypoid and Nonpolypoid Precancerous Colorectal Lesions. PLoS ONE. 2016;11:e0159373 pubmed publisher
    ..These findings were mirrored by tissue immunostaining with CD4, CD8, FOXP3, MHC-I, CD68, and CD163 antibodies: stromal immune cell counts (mainly T lymphocytes and macrophages) were significantly higher in ..
  46. Hollmen M, Karaman S, Schwager S, Lisibach A, Christiansen A, Maksimow M, et al. G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer. Oncoimmunology. 2016;5:e1115177 pubmed
    ..001) and associated with CD163+ macrophages (p < 0.0001), poorer overall survival (OS) (p = 0...
  47. Nagai M, Hirayama K, Ebihara I, Higuchi T, Shimohata H, Kobayashi M. Serum levels of the soluble haemoglobin scavenger receptor CD163 in MPO-ANCA-associated renal vasculitis. Scand J Rheumatol. 2016;45:397-403 pubmed publisher
    ..We investigated the usefulness of the serum-soluble haemoglobin scavenger receptor CD163 for detecting the presence of infectious complications regardless of disease activity...
  48. Christophi G, Sharma Y, Farhan Q, Jain U, Walker T, Sayuk G, et al. Erdheim-Chester Disease presenting with histiocytic colitis and cytokine storm. J Gastrointestin Liver Dis. 2017;26:183-187 pubmed publisher
    ..Endoscopy showed segmental colitis and pathology revealed infiltration of large foamy histiocytes CD3-/CD20-/CD68+/CD163+/S100- consistent with ECD...
  49. Thirion Delalande C, Gervais F, Fisch C, Cuiné J, Baron Bodo V, Moingeon P, et al. Comparative analysis of the oral mucosae from rodents and non-rodents: Application to the nonclinical evaluation of sublingual immunotherapy products. PLoS ONE. 2017;12:e0183398 pubmed publisher
    ..detected in the 3 oral regions from rodent and non-rodent species include MHC-II+ antigen presenting cells, mostly CD163+ macrophages, located in the lamina propria (LP) and muscle tissue in the vicinity of resident CD3+CD4+ T cells...
  50. Keshtkar Jahromi M, Ouyang M, Keshtkarjahromi M, Almed S, Li H, Walston J, et al. Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults. Vaccine. 2018;36:2220-2225 pubmed publisher
    ..Pre- and post-vaccination levels of TWEAK, soluble CD163 (sCD163) and strain-specific influenza antibody titers were measured in 69 participants...
  51. Wu X, Schulte B, Zhou Y, Haribhai D, MacKinnon A, Plaza J, et al. Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo. J Invest Dermatol. 2014;134:2814-2822 pubmed publisher
    ..Moreover, we detected CD163, a reliable marker of tumor-associated macrophages, in the tumor microenvironment of MF biopsies...
  52. Moeller J, Nielsen M, Reichhardt M, Schlosser A, Sorensen G, Nielsen O, et al. CD163-L1 is an endocytic macrophage protein strongly regulated by mediators in the inflammatory response. J Immunol. 2012;188:2399-409 pubmed publisher
    ..family of proteins, where the CD163-L1 gene arose by duplication of the gene encoding the hemoglobin scavenger receptor CD163 in late evolution...
  53. Fujimura M, Fujimura T, Kakizaki A, Sato Maeda M, Niizuma K, Tomata Y, et al. Increased serum production of soluble CD163 and CXCL5 in patients with moyamoya disease: Involvement of intrinsic immune reaction in its pathogenesis. Brain Res. 2018;1679:39-44 pubmed publisher
    ..We compared the serum level of soluble (s)CD163, an activating marker for CD163+ M2-polarized macrophages that has been implicated in a variety of autoimmune ..
  54. Madsen M, Møller H, Nielsen M, Jacobsen C, Graversen J, van den Berg T, et al. Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region. J Biol Chem. 2004;279:51561-7 pubmed
    b>CD163 is the macrophage receptor for endocytosis of haptoglobin.hemoglobin complexes. The extracellular region consisting of nine scavenger receptor cysteine rich (SRCR) domains also circulates in plasma as a soluble protein...
  55. Shimada R, Fujimura T, Kambayashi Y, Ohtani T, Nasu M, Numata Y, et al. CD163+ adult xanthogranuloma arising from Merkel cell carcinoma treated with local radiotherapy. Acta Derm Venereol. 2012;92:631-2 pubmed publisher
  56. Chen S, Zheng P, Wang W, Yi M, Chen P, Cai J, et al. Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma. J Cell Physiol. 2018;233:5002-5013 pubmed publisher
    ..Immunofluoresence assay indicates NOR1 protein is mainly expressed at CD163 positive M2 tumor associated macrophages (TAMs)...
  57. Zhang Q, Hwang J, Oh J, Park C, Chung S, Lee Y, et al. Effects of the fibrous topography-mediated macrophage phenotype transition on the recruitment of mesenchymal stem cells: An in vivo study. Biomaterials. 2017;149:77-87 pubmed publisher
    ..supported the macrophage phenotype transition from M1-to-M2, which was confirmed by the ratio of M2/M1 marker (CD163/CCR7)-positive cells and by the expression of M2/M1 markers (arginase-1/iNOS)...
  58. Kridel R, Xerri L, Gelas Dore B, Tan K, Feugier P, Vawda A, et al. The Prognostic Impact of CD163-Positive Macrophages in Follicular Lymphoma: A Study from the BC Cancer Agency and the Lymphoma Study Association. Clin Cancer Res. 2015;21:3428-35 pubmed publisher
    ..We applied immunohistochemistry for CD68 and CD163 to two large tissue microarrays (TMA)...
  59. Provost C, Hamonic G, Gagnon C, Meurens F. Dual infections of CD163 expressing NPTr epithelial cells with influenza A virus and PRRSV. Vet Microbiol. 2017;207:143-148 pubmed publisher
    ..In the current report, an epithelial cell line expressing, CD163, the main receptor of PRRSV was generated...
  60. Craig D, Lee P, Pryde E, Hayes P, Simpson K. Serum neopterin and soluble CD163 as markers of macrophage activation in paracetamol (acetaminophen)-induced human acute liver injury. Aliment Pharmacol Ther. 2013;38:1395-404 pubmed publisher
    ..Neopterin is synthesised from macrophages and reflects the intensity of monocyte/macrophage activation. Soluble CD163 (sCD163) is a marker of alternatively activated M2 macrophages...
  61. Vyas M, Reinartz S, Hoffmann N, Reiners K, Lieber S, Jansen J, et al. Soluble NKG2D ligands in the ovarian cancer microenvironment are associated with an adverse clinical outcome and decreased memory effector T cells independent of NKG2D downregulation. Oncoimmunology. 2017;6:e1339854 pubmed publisher
    ..correlation of soluble NKG2D ligands with effector memory T cells and a direct correlation with pro-tumorigenic CD163+CD206+ macrophages was observed...
  62. O Connell G, Chantler P, Barr T. Stroke-associated pattern of gene expression previously identified by machine-learning is diagnostically robust in an independent patient population. Genom Data. 2017;14:47-52 pubmed publisher
    ..Expression levels of the ten candidate genes (ANTXR2, STK3, PDK4, CD163, MAL, GRAP, ID3, CTSZ, KIF1B, and PLXDC2) were extracted, compared ..
  63. Kim W, Alvarez X, Fisher J, Bronfin B, Westmoreland S, McLaurin J, et al. CD163 identifies perivascular macrophages in normal and viral encephalitic brains and potential precursors to perivascular macrophages in blood. Am J Pathol. 2006;168:822-34 pubmed
    ..Here, we present the macrophage scavenger receptor CD163 as a marker for perivascular macrophages in humans, monkeys, and mice...
  64. Van Gorp H, Van Breedam W, Delputte P, Nauwynck H. The porcine reproductive and respiratory syndrome virus requires trafficking through CD163-positive early endosomes, but not late endosomes, for productive infection. Arch Virol. 2009;154:1939-43 pubmed publisher
    ..Furthermore, it was shown that PRRSV colocalizes with its internalization receptor, sialoadhesin, on the cell surface and beneath the plasma membrane, while CD163 and PRRSV only meet in early endosomes.
  65. Jeong J, Hong S, Kwon O, Ghang B, Hwang I, Kim Y, et al. CD14+ Cells with the Phenotype of Infiltrated Monocytes Consist of Distinct Populations Characterized by Anti-inflammatory as well as Pro-inflammatory Activity in Gouty Arthritis. Front Immunol. 2017;8:1260 pubmed publisher
    ..In addition, anti-inflammatory features, including CD163 expression and IL-10 production from CD14+ cells, were significantly higher in patients with gout than ..
  66. Tuluc F, Meshki J, Spitsin S, Douglas S. HIV infection of macrophages is enhanced in the presence of increased expression of CD163 induced by substance P. J Leukoc Biol. 2014;96:143-50 pubmed publisher
    Activation of NK1R by SP contributes to increased HIV-1 infection in macrophages. The scavenger receptor CD163 is expressed on cells of monocyte-macrophage origin...
  67. Durnford A, Dunbar J, Galea J, Bulters D, Nicoll J, Boche D, et al. Haemoglobin scavenging after subarachnoid haemorrhage. Acta Neurochir Suppl. 2015;120:51-4 pubmed publisher
    ..Haemoglobin is avidly bound by haptoglobin, and the complex is cleared by CD163 expressed on the membrane surface of macrophages...
  68. Gleissner C, Shaked I, Erbel C, Böckler D, Katus H, Ley K. CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages. Circ Res. 2010;106:203-11 pubmed publisher
    ..factor (M-CSF)- and CXCL4-induced macrophages demonstrated virtually complete absence of the hemoglobin scavenger receptor CD163 in CXCL4-induced macrophages. mRNA for CD163 was downregulated as early as 2 hours after CXCL4...